{"id":17454,"date":"2018-07-30T01:00:00","date_gmt":"2018-08-08T00:58:45","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/08\/%e6%96%b0%e5%9e%8b%e5%8f%a3%e6%9c%8d%e6%8a%97%e5%87%9d%e8%a1%80%e8%8d%af%e7%89%a9%e5%85%a8%e7%90%83%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95\/"},"modified":"2018-08-08T08:58:48","modified_gmt":"2018-08-08T00:58:48","slug":"%e6%96%b0%e5%9e%8b%e5%8f%a3%e6%9c%8d%e6%8a%97%e5%87%9d%e8%a1%80%e8%8d%af%e7%89%a9%e5%85%a8%e7%90%83%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/17454\/","title":{"rendered":"\u65b0\u578b\u53e3\u670d\u6297\u51dd\u8840\u836f\u7269\u5168\u7403\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"
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\u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug \u25b2 \u6dfb\u52a0\u5173\u6ce8<\/span><\/p>\n


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\u5f53\u524d\u6211\u56fd\u4e34\u5e8a\u4e0a\u4f7f\u7528\u7684\u6297\u51dd\u8840\u836f\u7269\u4e3b\u8981\u662f\u809d\u7d20\u7c7b\u6297\u51dd\u5242\u3001\u7ef4\u751f\u7d20<\/span>K<\/span>\u62ee\u6297\u5242\uff0c\u867d\u7136\u5728\u6297\u8840\u6813\u6cbb\u7597\u4e0a\u6709\u8f83\u597d\u6548\u679c\uff0c\u4f46\u5b58\u5728\u4e00\u5b9a\u7684\u4e0d\u8db3\uff0c\u5305\u62ec\u8d77\u6548\u6162\u3001\u6cbb\u7597\u8303\u56f4\u7a84\uff0c\u4e14\u5747\u9700\u52a0\u5f3a\u8840\u6db2\u76d1\u6d4b<\/span>[1]<\/sup><\/span>\u3002\u56e0\u5e38\u89c4\u6297\u51dd\u8840\u836f\u7269\u5b58\u5728\u7684\u4e0d\u8db3\uff0c\u7814\u7a76\u4eba\u5458\u8d8a\u53d1\u4e13\u6ce8\u4e8e\u65b0\u578b\u53e3\u670d\u6297\u51dd\u8840\u836f\u7269\u7684\u7814\u53d1\uff0c\u53d1\u73b0<\/span>Xa<\/span>\u56e0\u5b50\u6291\u5236\u5242\uff0c\u5176\u4e2d\u4ee3\u8868\u836f\u7269\u5982\u5229\u4f10\u6c99\u73ed\u3001\u963f\u54cc\u6c99\u73ed\u3001\u4f9d\u5ea6\u6c99\u73ed\u4ee5\u53ca\u8fd1\u671f\u4e0a\u5e02\u7684\u8d1d\u66f2\u6c99\u73ed<\/span>[2, 3]<\/sup><\/span>\u3002\u8be5\u7c7b\u836f\u7269\u7684\u53e3\u670d\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u6d3b\u6027\u53ca\u836f\u6548\u5747\u53ef\u6709\u6548\u9884\u6d4b\uff0c\u53d7\u5176\u4ed6\u836f\u7269\u5f71\u54cd\u8f83\u5c0f\uff0c\u6cbb\u7597\u8303\u56f4\u5bbd<\/span>[4]<\/sup><\/span>\u3002\u6211\u56fd\u4e5f\u76f8\u7ee7\u6709\u65b0\u578b\u53e3\u670d\u6297\u51dd\u8840\u836f\u7269\u8fdb\u5165\u4e34\u5e8a\uff08\u534e\u5317\u5236\u836f\u51dd\u8840\u56e0\u5b50<\/span>Xa<\/span>\u6291\u5236\u5242\uff1a<\/span>WA1-089<\/span>\uff09\u3002\u968f\u7740\u5168\u7403\u65b0\u578b\u53e3\u670d\u6297\u51dd\u8840\u836f\u7269\u7684\u4e0a\u5e02\uff0c\u672a\u6765\u6211\u56fd\u7684\u6297\u51dd\u8840\u836f\u7269\u5e02\u573a\u5c06\u9010\u6e10\u88ab<\/span>Xa<\/span>\u56e0\u5b50\u6291\u5236\u5242\u5360\u636e\u3002<\/span><\/span><\/p>\n


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1<\/strong><\/span>\u6297\u51dd\u8840\u836f\u7269\u6d41\u884c\u75c5\u5b66\u8bc4\u4ef7<\/strong><\/span><\/span><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u8840\u6813\u4e0d\u4ec5\u662f\u9020\u6210\u52a8\u8109\u75be\u75c5\u53d1\u75c5\u548c\u6b7b\u4ea1\u4e00\u4e2a\u4e3b\u8981\u56e0\u7d20\uff0c\u6bd4\u5982\u5fc3\u808c\u6897\u6b7b\u548c\u8111\u5352\u4e2d\uff0c\u4e5f\u662f\u9759\u8109\u8840\u6813\u6027\u75be\u75c5\uff08<\/span>VTE<\/span>\uff09\u7684<\/span>\u201c<\/span>\u7f6a\u9b41\u7978\u9996<\/span>\u201d<\/span>\uff0c\u6bd4\u5982\u6df1\u90e8\u9759\u8109\u8840\u6813\u6813\u585e\u548c\u80ba\u6813\u585e\u3002<\/span>VTE<\/span>\u662f\u9020\u6210\u5fc3\u8840\u7ba1\u75be\u75c5\u76f8\u5173\u6b7b\u4ea1\u7684\u7b2c\u4e09\u5927\u539f\u56e0\uff0c\u4ec5\u6b21\u4e8e\u5fc3\u808c\u6897\u6b7b\u548c\u5352\u4e2d\uff0c\u4e5f\u662f\u80bf\u7624\u60a3\u8005\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\u3002\u6297\u8840\u6813\u836f\u7269\uff0c\u5305\u62ec\u6297\u51dd\u5242\u3001\u6297\u8840\u5c0f\u677f\u836f\u7269\u4ee5\u53ca\u76f4\u63a5\u6eb6\u6813\u836f\u7269\uff0c\u5747\u53ef\u7528\u4e8e\u8840\u6813\u5f62\u6210\u7684\u9884\u9632\u6216\u6025\u6027\u671f\u7684\u6cbb\u7597\u3002\u5168\u7403\u6bcf\u5e74\u8111\u8840\u6813\u3001\u8111\u6897\u585e\u3001\u5fc3\u808c\u6897\u585e\u3001\u51a0\u5fc3\u75c5\u3001\u52a8\u8109\u786c\u5316\u7b49\u5fc3\u8111\u8840\u7ba1\u593a\u8d70<\/span>1200<\/span>\u4e07\u4eba\u7684\u751f\u547d\uff0c\u63a5\u8fd1\u4e16\u754c\u603b\u6b7b\u4ea1\u4eba\u6570\u7684\u56db\u5206\u4e4b\u4e00\uff0c\u6211\u56fd\u6bcf\u5e74\u6b7b\u4e8e\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u7684\u4eba\u6570\u4e3a<\/span>260<\/span>\u4e07\u4eba\uff0c\u5b58\u6d3b\u7684\u60a3\u8005<\/span>75%<\/span>\u81f4\u6b8b\u3002\u5728\u7f8e\u56fd\u3001\u82f1\u56fd\u3001\u5fb7\u56fd\u7b49\u53d1\u8fbe\u56fd\u5bb6\u4e2d\uff0c\u6bcf\u5e74\u5927\u7ea6\u6709<\/span>2400<\/span>\u4e07\u540d\u60a3\u8005\u4f1a\u7531\u4e8e\u5fc3\u529b\u8870\u7aed\u3001\u4e2d\u98ce\u3001\u611f\u67d3\u3001\u547c\u5438\u75be\u75c5\u7b49\u7d27\u6025\u72b6\u51b5\u5165\u9662\u63a5\u53d7\u6cbb\u7597\u3002\u5728\u4f4f\u9662\u671f\u95f4\uff0c\u6216\u662f\u51fa\u9662\u540e\uff0c\u8fd9\u4e9b\u60a3\u8005\u7531\u4e8e\u75c5\u60c5\u7684\u5f71\u54cd\uff0c\u884c\u52a8\u5f80\u5f80\u4f1a\u53d7\u5230\u5f88\u5927\u7684\u9650\u5236\u3002\u4e45\u8eba\u4e8e\u75c5\u5e8a\u4e4b\u4e0a\u7684\u4ed6\u4eec\uff0c\u51fa\u73b0\u6df1\u9759\u8109\u8840\u6813\u5f62\u6210\uff08<\/span>DVT<\/span>\uff09\u548c\u80ba\u6813\u585e\uff08<\/span>PE<\/span>\uff09\u7684\u98ce\u9669\u4f1a\u4e0a\u5347\u3002\u636e\u4f30\u8ba1\uff0c\u6bcf\u5e74\u8fd9\u4e9b\u9759\u8109\u8840\u6813\u6813\u585e\u5bfc\u81f4\u7684\u533b\u7597\u4e8b\u4ef6\u8d85\u8fc7<\/span>100<\/span>\u4e07\u9879\uff0c\u5e76\u6709\u8d85\u8fc7<\/span>15<\/span>\u4e07\u4eba\u56e0\u8fd9\u79cd\u75be\u75c5\u6b7b\u4ea1\u3002\u672a\u6765<\/span>20<\/span>\u5e74\u662f\u4e2d\u56fd\u8001\u5e74\u4eba\u53e3\u589e\u957f\u6700\u5feb\u7684\u65f6\u671f\uff0c\u9884\u8ba1\u5230<\/span>2020<\/span>\u5e74\uff0c\u6211\u56fd<\/span>60<\/span>\u5c81\u4ee5\u4e0a\u8001\u5e74\u4eba\u53e3\u5c06\u8fbe<\/span>2.6<\/span>\u4ebf\u4eba\uff0c\u5360\u603b\u4eba\u53e3\u7684<\/span>17.8%<\/span>\uff0c\u9884\u8ba1<\/span>2033<\/span>\u5e74\u524d\u540e\u5c06\u8fbe\u5230<\/span>4<\/span>\u4ebf\uff0c\u5e73\u5747\u6bcf\u5e74\u589e\u52a0<\/span>1000<\/span>\u4e07\uff0c\u6700\u9ad8\u5e74\u4efd\u5c06\u589e\u52a0<\/span>1400<\/span>\u591a\u4e07\u3002\u56fd\u5185\u5916\u5bf9\u9884\u9632\u548c\u6cbb\u7597\u8840\u6813\u6027\u75be\u75c5\u836f\u7269\u9700\u6c42\u91cf\u5de8\u5927\uff0c<\/span>2013<\/span>\u5e74\u5168\u7403\u6297\u8840\u6813\u836f\u7269\u5e02\u573a\u9500\u552e\u989d\u8fbe<\/span>235<\/span>\u4ebf\u7f8e\u5143\uff0c\u9884\u8ba1<\/span>2018<\/span>\u5e74\u8fbe<\/span>259<\/span>\u4ebf\u7f8e\u5143\u3002\u5728\u6211\u56fd\uff0c\u6837\u672c\u57ce\u5e02<\/span>2015<\/span>\u5e74\u6297\u51dd\u8840\u836f\u7269\u5e02\u573a\u8fbe<\/span>30<\/span>\u4ebf\u5143\uff0c\u9884\u8ba1<\/span>2020<\/span>\u5e74\u6211\u56fd\u6297\u51dd\u8840\u836f\u7269\u5e02\u573a\u5c06\u8d85\u8fc7<\/span>100<\/span>\u4ebf\u5143\u3002<\/span>
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2<\/strong><\/span>\u53e3\u670d\u6297\u51dd\u8840\u836f\u7269<\/span><\/strong><\/strong><\/span><\/span><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u534e\u6cd5\u6797\uff1a<\/span><\/strong><\/span><\/p>\n

\u7ef4\u751f\u7d20<\/span>K\u62ee\u6297\u5242\u534e\u6cd5\u6797\u662f<\/span>50\u5e74\u6765\u9996\u4e2a\u7684\u53e3\u670d\u6297\u51dd\u836f\u7269\uff0c\u5e7f\u6cdb\u5e94\u7528\u4e8e\u8840\u6813\u6813\u585e\u4e8b\u4ef6\u7684\u9884\u9632\uff0c\u4e3b\u8981\u662f\u7528\u5728\u80ba\u6813\u585e\uff0c\u6df1\u9759\u8109\u8840\u6813\u7b49\u9759\u8109\u7cfb\u7edf\u7684\u8840\u6813\u75be\u75c5\uff0c\u4ee5\u53ca\u623f\u98a4\uff0c\u8fd8\u6709\u6362\u74e3\u7684\u75c5\u4eba\u7684\u9884\u9632\u8840\u6813\u884c\u6210\u3002\u534e\u6cd5\u6797\u6297\u8840\u6813\u6548\u679c\u660e\u786e\u3001\u53ef\u9760\uff0c\u4f46\u4e5f\u5b58\u5728\u4e00\u4e9b\u7f3a\u9677\uff0c\u5982\u6cbb\u7597\u7a97\u53e3\u7a84\uff0c\u9700\u8981\u9891\u7e41\u76d1\u6d4b\u51dd\u8840\u529f\u80fd\uff0c\u6cbb\u7597\u53cd\u5e94\u4e2a\u4f53\u5dee\u5f02\u5927\uff0c\u5bb9\u6613\u53d7\u98df\u7269\u3001\u836f\u7269\u7684\u5f71\u54cd\uff0c\u8d77\u6548\u548c\u5931\u6548\u65f6\u95f4\u957f\u7b49\u3002\u8fd1\u5e74\u6765\uff0c\u65b0\u578b\u53e3\u670d\u6297\u51dd\u836f\u7269<\/span>(neworal anti-coagulants\uff0c<\/span>NOAC) \u7684\u51fa\u73b0\u4e3a\u6297\u8840\u6813\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u9009\u62e9\uff0c<\/span>NOAC\u4e3b\u8981\u5305\u62ec\u51dd\u8840\u9176\u6291\u5236\u5242<\/span>(\u8fbe\u6bd4\u52a0\u7fa4\u916f<\/span>)\u548c\u51dd\u8840\u56e0\u5b50<\/span>Xa\u6291\u5236\u5242<\/span>(\u5229\u4f10\u6c99\u73ed\u3001\u963f\u54cc\u6c99\u73ed\u3001\u4f9d\u5ea6\u6c99\u73ed<\/span>)[5]<\/sup>\u3002<\/span><\/span><\/p>\n


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\u8fbe\u6bd4\u52a0\u7fa4\u916f\uff1a<\/span><\/strong><\/span><\/p>\n

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\"\u65b0\u578b\u53e3\u670d\u6297\u51dd\u8840\u836f\u7269\u5168\u7403\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

<\/span>\u56fe<\/span>1 <\/span><\/strong>\u6297\u51dd\u8840\u836f\u7269\u4f5c\u7528\u673a\u5236\u56fe\u89e3<\/span><\/p>\n


<\/p>\n

\u5229\u4f10\u6c99\u73ed\uff1a<\/span><\/strong><\/span><\/p>\n

\u5229\u4f10\u6c99\u73ed<\/span>\u53ef\u4ee5\u7ade\u4e89\u6027\u7ed3\u5408\u51dd\u8840\u56e0\u5b50<\/span>Xa<\/span>\u4f4d\u70b9\uff0c\u751f\u7269\u5229\u7528\u5ea6\u9ad8\u3002\u5229\u4f10\u4ed6\u73ed\u5728\u80c3\u5185\u5438\u6536\uff0c\u5176\u4ee3\u8c22\u9014\u5f84\u6709\u4e24\u79cd\uff0c<\/span>1\/3<\/span>\u4ee5\u539f\u578b\u7684\u5f62\u5f0f\u901a\u8fc7\u80be\u810f\u4ee3\u8c22\uff0c<\/span>67%<\/span>\u5728\u809d\u810f\u4e2d\u7ecf<\/span>CYP3A4<\/span>\u8f6c\u5316\u4e3a\u65e0\u6d3b\u6027\u7684\u4ee3\u8c22\u4ea7\u7269\u3002\u670d\u7528<\/span>P<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u548c\u8bf1\u5bfc\u5242\u3001\u809d\u529f\u80fd\u5f02\u5e38\u7684\u60a3\u8005\u4e0d\u5b9c\u4f7f\u7528\u5229\u4f10\u6c99\u73ed\u3002\u963f\u54cc\u6c99\u73ed\u901a\u8fc7\u809d\u810f\u4ee3\u8c22\uff0c<\/span>75%<\/span>\u901a\u8fc7\u7caa\u4fbf\u6392\u51fa\uff0c<\/span>25%<\/span>\u901a\u8fc7\u80be\u810f\u6392\u51fa\u3002<\/span>CYP3A4<\/span>\u548c<\/span>P<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u5bfc\u81f4\u8840\u6d46\u4e2d\u963f\u54cc\u6c99\u73ed\u6d53\u5ea6\u5347\u9ad8\uff0c\u6b64\u65f6\u5e94\u8be5\u964d\u4f4e\u963f\u54cc\u6c99\u73ed\u7684\u5242\u91cf<\/span>[4]<\/sup><\/span>\u3002\u809d\u529f\u80fd\u8f7b\u5ea6\u5f02\u5e38\u65f6\uff0c\u65e0\u9700\u8c03\u6574\u963f\u54cc\u6c99\u73ed\u7684\u5242\u91cf\uff0c\u4e2d\u3001\u91cd\u5ea6\u809d\u529f\u80fd\u5f02\u5e38\u65f6\uff0c\u4e0d\u9002\u5e94\u7528\u963f\u54cc\u6c99\u73ed<\/span>[8]<\/sup><\/span>\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u5229\u4f10\u6c99\u73ed\u662f\u62dc\u8033\u5904\u65b9\u836f\u9886\u57df\u9010\u9e7f\u56fd\u5185\u5fc3\u8840\u7ba1\u6cbb\u7597\u7684\u4e00\u628a\u5229\u5668\u3002<\/span>2009\u5e74<\/span>6\u6708\uff0c\u5229\u4f10\u6c99\u73ed\u83b7\u6279\u8fdb\u5165\u4e2d\u56fd\u5e02\u573a\uff0c\u7528\u4e8e\u6210\u4eba\u62e9\u671f\u5168\u9acb\u6216\u5168\u819d\u5173\u8282\u7f6e\u6362\u672f\u540e\u9759\u8109\u8840\u6813\u7684\u9884\u9632\u3002\u6b64\u540e\u9646\u7eed\u6709\u591a\u4e2a\u9002\u5e94\u8bc1\u5728\u4e2d\u56fd\u83b7\u6279\uff0c<\/span>2017\u5e74<\/span>4\u6708\u5229\u4f10\u6c99\u73ed\u53c8\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u80ba\u6813\u585e\uff0c\u6210\u4e3a\u7b2c\u4e00\u4e2a\u5728\u4e2d\u56fd\u88ab\u6279\u51c6\u7528\u4e8e\u80ba\u6813\u585e\u6cbb\u7597\u7684\u65b0\u578b\u53e3\u670d\u6297\u51dd\u836f<\/span>[9]<\/sup>\u3002<\/span>2017\u5e74<\/span>8\u6708<\/span>28\u65e5\uff0c\u62dc\u8033\u65b0\u578b\u53e3\u670d\u6297\u51dd\u836f\u7269\u5229\u4f10\u6c99\u73ed\u7528\u4e8e\u51a0\u72b6\u52a8\u8109\u75be\u75c5\u6216\u5916\u5468\u52a8\u8109\u75be\u75c5\u4e8c\u7ea7\u9884\u9632\u7684\u5927\u578b<\/span>III \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08<\/span>COMPASS\uff09\u7814\u7a76\u7ed3\u679c\u5728<\/span>2017\u6b27\u6d32\u5fc3\u810f\u75c5\u5b66\uff08<\/span>ESC\uff09\u5e74\u4f1a\u4e0a\u6b63\u5f0f\u53d1\u5e03\u3002\u4ee4\u5168\u573a\u6cb8\u817e\u7684\u7ed3\u679c\u662f\uff1a\u5229\u4f10\u6c99\u73ed\u663e\u8457\u964d\u4f4e\u6162\u6027\u51a0\u72b6\u52a8\u8109\u6216\u5916\u5468\u52a8\u8109\u75be\u75c5\u60a3\u8005\u5352\u4e2d\u3001\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u548c\u5fc3\u810f\u75c5\u590d\u5408\u98ce\u9669\u8fbe<\/span>24%\u3002\u636e\u6089\uff0c<\/span>COMPASS\u63a2\u8ba8\u4e86\u4e09\u79cd\u4e0d\u540c\u7684\u6297\u8840\u6813\u6cbb\u7597\u65b9\u6848\uff0c\u5305\u62ec\u5355\u7528\u5229\u4f10\u6c99\u73ed\u3001\u5355\u7528\u963f\u53f8\u5339\u6797\u4ee5\u53ca\u5229\u4f10\u6c99\u73ed\u8054\u5408\u963f\u53f8\u5339\u6797\uff0c\u7528\u4e8e<\/span>CAD\u6216<\/span>PAD\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u6574\u4e2a\u7814\u7a76\u7eb3\u5165\u4e86\u5168\u7403<\/span>30\u591a\u4e2a\u56fd\u5bb6\uff0c<\/span>600\u591a\u4e2a\u4e2d\u5fc3\u7684<\/span>27400\u540d\u786e\u8bca\u51a0\u72b6\u52a8\u8109\u75be\u75c5\uff08<\/span>CAD\uff09\u6216\u5916\u5468\u52a8\u8109\u75be\u75c5\uff08<\/span>PAD\uff09\u7684\u60a3\u8005\u3002\u8fd9\u662f\u5229\u4f10\u6c99\u73ed\u8fc4\u4eca\u4e3a\u6b62\u6700\u5927\u89c4\u6a21\u7684\u7814\u7a76\uff0c\u56e0\u663e\u793a\u51fa\u538b\u5012\u6027\u7684\u6709\u6548\u6027\u4f18\u52bf\u800c\u5148\u4e8e\u8ba1\u5212\u63d0\u524d\u7ea6\u4e00\u5e74\u4e88\u4ee5\u7ec8\u6b62\u3002\u5176\u91cd\u5927\u7a81\u7834\u5728\u4e8e\uff1a\u5229\u4f10\u6c99\u73ed\u52a8\u8109\u5242\u91cf<\/span>2.5mg\u4e00\u5929\u4e24\u6b21\u52a0\u963f\u53f8\u5339\u6797<\/span>100mg\u4e00\u5929\u4e00\u6b21\u7684\u8054\u5408\u7597\u6cd5\u8f83\u5355\u7528\u963f\u53f8\u5339\u6797\u800c\u8a00\u53f2\u65e0\u524d\u4f8b\u5730\u964d\u4f4e\u5352\u4e2d\u76f8\u5bf9\u98ce\u9669<\/span>42%\uff0c\u964d\u4f4e\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u98ce\u9669<\/span>22%\uff1b\u8054\u5408\u7597\u6cd5\u5728\u4e34\u5e8a\u51c0\u83b7\u76ca\u65b9\u9762\u5927\u5e45\u63d0\u9ad8<\/span>20%\u3002<\/span><\/span><\/p>\n


<\/p>\n

\u963f\u54cc\u6c99\u73ed\uff1a<\/span><\/strong><\/span><\/p>\n

\u963f\u54cc\u6c99\u73ed\u53ef\u76f4\u63a5\u6291\u5236\u51dd\u8840\u56e0\u5b50<\/span>Xa\uff0c\u963b\u65ad\u51dd\u8840\u7ea7\u8054\u8fc7\u7a0b\u4e2d\u51dd\u8840\u9176\u539f\u8f6c\u5316\u6210\u51dd\u8840\u9176\u3002\u51dd\u8840\u56e0\u5b50<\/span>Xa\u56e0\u5b50\u662f\u4e00\u4e2a\u7ef4\u751f\u7d20<\/span>K\u4f9d\u8d56\u7684\u4e1d\u6c28\u9178\u86cb\u767d\u9176\uff0c\u5176\u5360\u636e\u4e86\u51dd\u8840\u7011\u5e03\u53cd\u5e94\u4e2d\u7684\u4e2d\u5fc3\u4f4d\u7f6e\uff0c\u53ef\u4ee5\u7531\u5185\u6e90\u6027\u548c\u5916\u6e90\u6027\u51dd\u8840\u9014\u5f84\u6fc0\u6d3b\uff0c\u4e3b\u8981\u50ac\u5316\u2161\u56e0\u5b50<\/span>(\u51dd\u8840\u9176\u539f<\/span>)\u5411\u2161<\/span>a\u56e0\u5b50<\/span>(\u51dd\u8840\u9176<\/span>)\u8f6c\u5316\uff0c\u6291\u5236<\/span>1molXa\u56e0\u5b50\u53ef\u4ee5\u6291\u5236<\/span>1000mol\u51dd\u8840\u9176\u7684\u4ea7\u751f\u3002\u7814\u7a76\u8868\u660e\uff0c\u6291\u5236<\/span>Xa\u56e0\u5b50\u53ef\u4ee5\u5ef6\u957f\u6ede\u540e\u671f\u7684\u5242\u91cf\u4f9d\u8d56\u6548\u5e94\u3002<\/span>Xa\u56e0\u5b50\u7ed3\u6784\u4e2d\u542b\u6709<\/span>S1\uff5e<\/span>S4\u53e3\u888b\u3001\u50ac\u5316\u533a\u57df\u3001\u9633\u79bb\u5b50\u7a7a\u6d1e\u3001\u4e8c\u786b\u6865\u53e3\u888b\u7b49\uff0c\u5176\u4e2d<\/span>S1\u548c<\/span>S4\u53e3\u888b\u662f\u836f\u7269\u7ed3\u5408\u7684\u4e3b\u8981\u53e3\u888b\u3002\u963f\u54cc\u6c99\u73ed\u4e0e<\/span>Xa\u6d3b\u6027\u90e8\u5206\u7ed3\u5408\u7684\u8fc7\u7a0b\u4e2d\uff0c\u5177\u6709\u9ad8\u5ea6\u7684\u9009\u62e9\u6027\uff0c\u4e0e<\/span>Xa\u7ed3\u5408\u7684\u89e3\u79bb\u5e38\u6570<\/span>Ki\u4e3a<\/span>0.08nmol\/L(\u5229\u4f10\u6c99\u73ed\u5bf9<\/span>Xa\u7684<\/span>Ki\u4e3a<\/span>0.4nmol\/L)\uff0c\u4e0e\u5176\u4ed6\u4e1d\u6c28\u9178\u86cb\u767d\u9176\u7684<\/span>Ki>3mol\/L\uff0c\u6545\u963f\u54cc\u6c99\u73ed\u5bf9<\/span>Xa\u9009\u62e9\u6027\u9ad8\u3001\u4f5c\u7528\u5f3a\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u963f\u54cc\u6c99\u73ed\u7684\u53e6\u4e00\u7279\u70b9\u662f\u5b83\u4e0d\u4ec5\u53ef\u6291\u5236\u6e38\u79bb\u7684<\/span>Xa\u53ca\u51dd\u8840\u9176\u539f\u590d\u5408\u7269\u4e2d\u7684<\/span>Xa\uff0c\u5c1a\u53ef\u6291\u5236\u8840\u51dd\u5757\u4e2d\u7684<\/span>Xa\uff0c\u4e14\u5728\u6291\u5236\u8fc7\u7a0b\u4e2d\u65e0\u9700\u6297\u51dd\u8840\u9176\u2162\uff0c\u8fd9\u4e0e\u809d\u7d20\u7c7b\u6297\u51dd\u836f\u5982\u78fa\u8fbe\u809d\u7678\u94a0\u7684\u4f5c\u7528\u4e0d\u540c<\/span>[10-14]<\/sup>\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u8d1d\u66f2\u6c99\u73ed\uff1a<\/span><\/strong><\/span><\/p>\n

\u7531<\/span>Portola Pharmaceuticals<\/span>\u5e26\u6765\u7684<\/span><\/span>Betrixaban<\/span>\u662f\u4e00\u6b3e\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684\u51dd\u8840\u56e0\u5b50\u56e0\u5b50<\/span>Xa<\/span>\u6291\u5236\u5242\u3002\u51dd\u8840\u56e0\u5b50<\/span>Xa<\/span>\u662f\u4e00\u79cd\u5728\u4eba\u4f53\u5185\u8d77\u5230\u5173\u952e\u51dd\u8840\u4f5c\u7528\u7684\u86cb\u767d\u8d28\uff0c\u5b83\u80fd\u5207\u5f00\u51dd\u8840\u9176\u7684\u524d\u4f53\uff0c\u4f7f\u51dd\u8840\u9176\u5177\u6709\u6d3b\u6027\u3002\u5018\u82e5\u56e0\u5b50<\/span>Xa<\/span>\u51fa\u73b0\u4e25\u91cd\u4e0d\u8db3\uff0c\u5c31\u4f1a\u5bfc\u81f4\u9f3b\u8840\u3001\u5173\u8282\u8840\u80bf\u3001\u4ee5\u53ca\u80a0\u80c3\u9053\u51fa\u8840\u7b49\u75c7\u72b6\u3002\u5229\u7528\u8fd9\u4e00\u539f\u7406\uff0c<\/span>Betrixaban<\/span>\u901a\u8fc7\u6291\u5236\u56e0\u5b50<\/span>Xa<\/span>\uff0c\u53ef\u4ee5\u8d77\u5230\u6291\u5236\u51dd\u8840\u7684\u4f5c\u7528\uff0c\u9632\u6b62\u9759\u8109\u8840\u6813\u6813\u585e\u5f62\u6210\uff08\u89c1\u4e0b\u56fe\uff09<\/span>[15, 16]<\/sup><\/span>\u3002\u8fd9\u6b3e\u521b\u65b0\u7597\u6cd5\u5148\u524d\u66fe\u83b7\u5f97\u7f8e\u56fd<\/span>FDA<\/span>\u9881\u53d1\u7684\u5feb\u901f\u901a\u9053\u8d44\u683c\uff0c\u4ee5\u53ca\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c<\/span>[17]<\/sup><\/span>\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\"\u65b0\u578b\u53e3\u670d\u6297\u51dd\u8840\u836f\u7269\u5168\u7403\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

\u56fe<\/span>2 <\/span><\/strong>Betrixaban<\/span>\u6297\u9759\u8109\u8840\u6813\u5f62\u6210<\/span><\/p>\n


<\/p>\n

\u5728\u4e00\u9879\u540d\u4e3a<\/span>APEX<\/span>\u7684\u5927\u578b\u968f\u673a\u3001\u53cc\u76f2\u3001\u591a\u4e2d\u5fc3\u7684<\/span>3<\/span>\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u8bc4\u4f30\u4e86<\/span>Betrixaban<\/span>\u7684\u7597\u6548\u3002\u8fd9\u9879\u7814\u7a76\u4ece\u5168\u7403<\/span>450<\/span>\u4e2a\u4e34\u5e8a\u4e2d\u5fc3\u62db\u52df\u4e86<\/span>7513<\/span>\u540d\u7531\u4e8e\u4e25\u91cd\u75c7\u72b6\u4f4f\u9662\u7684\u60a3\u8005\uff0c\u5e76\u5c06\u4ed6\u4eec\u968f\u673a\u5206\u4e3a\u4e24\u7ec4\u3002\u4e00\u7ec4\u63a5\u53d7\u4e86<\/span>6-14<\/span>\u5929\u7684\u4f9d\u8bfa\u809d\u7d20\u76ae\u4e0b\u6ce8\u5c04\uff0c\u968f\u540e\u63a5\u53d7\u4e86<\/span>35-42<\/span>\u5929\u7684\u5b89\u6170\u5242\u6cbb\u7597\u3002\u53e6\u4e00\u7ec4\u5219\u5148\u63a5\u53d7\u4e86<\/span>6-14<\/span>\u7684\u5b89\u6170\u5242\u6cbb\u7597\uff0c\u518d\u63a5\u53d7\u4e86<\/span>35-42<\/span>\u5929\u7684<\/span>Betrixaban<\/span>\u6cbb\u7597\u3002\u6709<\/span>7441<\/span>\u540d\u60a3\u8005\u7684\u9759\u8109\u8840\u6813\u6813\u585e\u75c5\u53d1\u6570\u636e\u88ab\u7528\u4e8e\u540e\u7eed\u5206\u6790\u3002\u7814\u7a76\u53d1\u73b0\uff0c<\/span>Betrixaban<\/span>\u964d\u4f4e\u4e86\u6df1\u9759\u8109\u8840\u6813\u5f62\u6210\u548c\u80ba\u6813\u585e\u7684\u53d1\u75c5\u7387\u3002\u5728\u63a5\u53d7<\/span>betrixaban<\/span>\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u51fa\u73b0\u9759\u8109\u8840\u6813\u6813\u585e\u7684\u6bd4\u4f8b\u4e3a<\/span>4.4%<\/span>\uff0c\u800c\u8fd9\u4e00\u6570\u5b57\u5728\u63a5\u53d7\u4f9d\u8bfa\u809d\u7d20\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u4e3a<\/span>6.0%<\/span>\uff08\u76f8\u5bf9\u98ce\u9669\u4e3a<\/span>0.75<\/span>\uff0c<\/span>95%<\/span>\u7f6e\u4fe1\u533a\u95f4\u4e3a<\/span>0.61<\/span>\uff0c<\/span>0.91<\/span>\uff09\u3002\u63a5\u53d7<\/span>Betrixaban<\/span>\u6cbb\u7597\u7684\u60a3\u8005\u6700\u4e3a\u5e38\u89c1\u7684\u526f\u4f5c\u7528\u662f\u51fa\u8840\uff0c\u51fa\u8840\u7387\u548c\u4f9d\u8bfa\u809d\u7d20\u6cbb\u7597\u7ec4\u76f8\u5f53\uff0c\u65e0\u663e\u8457\u5dee\u5f02\u3002\u4e1a\u5185\u591a\u540d\u8d44\u6df1\u5206\u6790\u4eba\u58eb\u6307\u51fa\uff0c\u5728\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5176\u4e3b\u8981\u76ee\u6807\u4eba\u7fa4\uff08<\/span>D-<\/span>\u4e8c\u805a\u4f53\u6c34\u5e73\u4e3a\u6807\u51c6\u4e0a\u9650\u4e24\u500d\u4ee5\u4e0a\uff09\u7684\u9759\u8109\u8840\u6813\u6813\u585e\u53d1\u75c5\u7387\u5206\u522b\u4e3a<\/span>6.9%<\/span>\uff08<\/span>Betrixaban<\/span>\u7ec4\uff09\u4e0e<\/span>8.5%<\/span>\uff08\u4f9d\u8bfa\u809d\u7d20\u7ec4\uff09\uff0c<\/span>Betrixaban<\/span>\u7ec4\u961f\u76f8\u5bf9\u98ce\u9669\u4e3a<\/span>0.81<\/span>\uff08<\/span>95%<\/span>\u7f6e\u4fe1\u533a\u95f4\u4e3a<\/span>0.65<\/span>\uff0c<\/span>1.00<\/span>\uff1b<\/span>p=0.054<\/span>\uff09\uff0c\u672a\u8fbe\u5230\u5176\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9<\/span>[18-20]<\/sup><\/span>\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u5728\u53d1\u5e03\u8bd5\u9a8c\u7ed3\u679c\u7684\u7814\u7a76\u8bba\u6587\u4e2d\uff0c\u5f3a\u8c03\u5728\u5176\u4ed6\u4eba\u7fa4\u4e2d\u53d6\u5f97\u7684\u4e34\u5e8a\u6548\u76ca\u6570\u636e\u4e3a<\/span>\u201c<\/span>\u63a2\u7d22\u6027<\/span>\u201d<\/span>\u3002\u4f46\u5728\u6570\u636e\u7684\u5206\u6790\u8ba8\u8bba\u4e2d\uff0c\u4ed6\u4eec\u6307\u51fa\uff0c\u7efc\u5408\u6765\u770b\uff0c\u5728\u5176\u4ed6\u4eba\u7fa4\u4e2d\u53d6\u5f97\u7684\u51fa\u8272\u6570\u636e\u5e94\u80fd\u652f\u6301<\/span>\u201cBetrixaban<\/span>\u964d\u4f4e\u9759\u8109\u8840\u6813\u6813\u585e\u53d1\u75c5\u7387<\/span>\u201d<\/span>\u8fd9\u4e00\u8bf4\u6cd5\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u76ee\u524d\u56fd\u5185\u4e0a\u5e02\u7684\u53e3\u670d\u6297\u51dd\u8840\u836f\u7269\u4e3b\u8981\u5305\u62ec\u534e\u6cd5\u6797\u3001\u8fbe\u6bd4\u52a0\u7fa4\u916f\u3001\u5229\u4f10\u6c99\u73ed\u53ca\u963f\u54cc\u6c99\u73ed\uff0c\u5176\u4f5c\u7528\u673a\u5236\u3001\u4ee3\u8c22\u9014\u5f84\u548c\u4e34\u5e8a\u5e94\u7528\u7279\u5f81\u5982\u4e0b\u8868\u6240\u793a\u3002\u6b64\u5916\uff0c\u534e\u5317\u5236\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\u4e8e<\/span>2017\u5e74<\/span>3\u6708\u6536\u5230\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u6838\u51c6\u7b7e\u53d1\u7684\u6297\u51dd\u8840\u65b0\u836f<\/span>WA1-089\u539f\u6599\u836f\u7684\u300a\u5ba1\u6279\u610f\u89c1\u901a\u77e5\u4ef6\u300b\u53ca\u7247\u5242<\/span>(1mg\u3001<\/span>10mg)\u7684\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\u3002<\/span>WA1-089\u7247\u5c5e\u4e8e\u51dd\u8840\u56e0\u5b50<\/span>Xa\u6291\u5236\u5242\uff0c\u9002\u5e94\u75c7\u7528\u4e8e\u62e9\u671f\u9acb\u5173\u8282\u6216\u819d\u5173\u8282\u7f6e\u6362\u624b\u672f\u6210\u5e74\u60a3\u8005\uff0c\u4ee5\u9884\u9632\u9759\u8109\u8840\u6813\u5f62\u6210\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u8868<\/span>1 <\/span><\/strong>\u53e3\u670d\u6297\u51dd\u8840\u836f\u7269\u4f5c\u7528\u7279\u5f81<\/span><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u7279\u6027<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u534e\u6cd5\u6797<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u8fbe\u6bd4\u52a0\u7fa4\u916f<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u5229\u4f10\u6c99\u73ed<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u963f\u54cc\u6c99\u73ed<\/span><\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u9776\u70b9<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u7ef4\u751f\u7d20<\/span>K<\/span><\/span><\/p>\n<\/td>\n

\n

\u51dd\u8840\u9176<\/span><\/p>\n<\/td>\n

\n

\u51dd\u8840\u56e0\u5b50<\/span>Xa<\/span><\/span><\/p>\n<\/td>\n

\n

\u51dd\u8840\u56e0\u5b50<\/span>Xa<\/span><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u524d\u4f53\u836f\u7269<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u5426<\/span><\/p>\n<\/td>\n

\n

\u662f<\/span><\/p>\n<\/td>\n

\n

\u5426<\/span><\/p>\n<\/td>\n

\n

\u5426<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u751f\u7269\u5229\u7528\u5ea6<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

95%<\/span><\/p>\n<\/td>\n

\n

6.5%<\/span><\/p>\n<\/td>\n

\n

80%<\/span><\/p>\n<\/td>\n

\n

66%<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Tmax<\/span><\/strong>\u8840\u6d46\u6d53\u5ea6<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

72-96h<\/span><\/p>\n<\/td>\n

\n

2h<\/span><\/p>\n<\/td>\n

\n

2.5-4h<\/span><\/p>\n<\/td>\n

\n

3h<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u534a\u8870\u671f<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

40h<\/span><\/p>\n<\/td>\n

\n

12-14h<\/span><\/p>\n<\/td>\n

\n

7-13h<\/span><\/p>\n<\/td>\n

\n

8-13h<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5e38\u89c4\u51dd\u8840\u68c0\u6d4b<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u662f<\/span><\/p>\n<\/td>\n

\n

\u5426<\/span><\/p>\n<\/td>\n

\n

\u5426<\/span><\/p>\n<\/td>\n

\n

\u5426<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5242\u91cf<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u6bcf\u65e5\u4e00\u6b21<\/span><\/p>\n<\/td>\n

\n

\u56fa\u5b9a\u5242\u91cf\u6bcf\u65e5\u4e24\u6b21<\/span><\/p>\n<\/td>\n

\n

\u56fa\u5b9a\u5242\u91cf\u6bcf\u65e5\u4e24\u6b21<\/span><\/p>\n<\/td>\n

\n

\u56fa\u5b9a\u5242\u91cf\u6bcf\u65e5\u4e24\u6b21<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4ee3\u8c22\u9014\u5f84<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u809d\u810f\u4ee3\u8c22<\/span><\/p>\n<\/td>\n

\n

80%<\/span>\u80be\u810f\u4ee3\u8c22<\/span><\/span><\/p>\n<\/td>\n

\n

67%<\/span>\u80be\u810f\u4ee3\u8c22<\/span><\/span><\/p>\n

33%<\/span>\u7caa\u4fbf\u4ee3\u8c22<\/span><\/span><\/p>\n<\/td>\n

\n

25%<\/span>\u80be\u810f\u4ee3\u8c22<\/span><\/span><\/p>\n

75%<\/span>\u7caa\u4fbf\u4ee3\u8c22<\/span><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u836f\u7269\u76f8\u4e92\u4f5c\u7528<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

CYP2C9\/3A4\/1A2<\/span><\/p>\n<\/td>\n

\n

P<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u548c\u8bf1\u5bfc\u5242<\/span><\/span><\/p>\n<\/td>\n

\n

CYP3A4<\/span>\u3001<\/span>P<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u548c\u8bf1\u5bfc\u5242<\/span><\/span><\/p>\n<\/td>\n

\n

CYP3A4<\/span>\u3001<\/span>P<\/span>\u7cd6\u86cb\u767d\u6291\u5236\u5242\u548c\u8bf1\u5bfc\u5242<\/span><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/span>
<\/p>\n

\n
\n
\n
\n

3<\/strong><\/span>\u56fd\u5185\u5916\u6297\u8840\u6813\u836f\u7269\u5e02\u573a\u60c5\u51b5<\/span><\/strong><\/strong><\/span><\/span><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u56fd\u5185\u5916\u5bf9\u9884\u9632\u548c\u6cbb\u7597\u8840\u6813\u6027\u75be\u75c5\u836f\u7269\u9700\u6c42\u91cf\u5de8\u5927\uff0c\u5168\u7403\u533b\u836f\u8d44<\/span>2014\u5e74\u516c\u5e03\u6570\u636e\u663e\u793a\uff0c<\/span>2013\u5e74\u5168\u7403\u6297\u8840\u6813\u836f\u7269\u5e02\u573a\u9500\u552e\u989d\u8fbe<\/span>235\u4ebf\u7f8e\u5143\uff0c\u5e76\u9884\u8ba1\u5728<\/span>2018\u5e74\u5168\u7403\u9500\u552e\u989d\u8fbe<\/span>259\u4ebf\u7f8e\u5143\u3002\u4ece<\/span>2010\u5e74\u5230<\/span>2015\u5e74\uff0c\u56fd\u5185\u6297\u8840\u6813\u836f\u7269\u7684\u5e74\u5e73\u5747\u589e\u957f\u7387\u8d85\u8fc7<\/span>10%\uff0c\u5177\u6709\u826f\u597d\u7684\u5e02\u573a\u53d1\u5c55\u524d\u666f\u3002\u76ee\u524d\u56fd\u5185\u6709<\/span>38\u4e2a\u6297\u8840\u6813\u836f\u7269\u4e0a\u5e02\uff0c\u5176\u4e2d<\/span>24\u4e2a\u836f\u7269\u7684<\/span>2015\u5e74\u6837\u672c\u57ce\u5e02\u9500\u552e\u989d\u8d85\u8fc7<\/span>1000\u4e07\u5143\uff0c\u603b\u8ba1\u5360\u6574\u4e2a\u6297\u8840\u6813\u836f\u7269\u5e02\u573a\u4efd\u989d\u7684<\/span>99%\u3002\u5728\u8fd9<\/span>24\u4e2a\u54c1\u79cd\u4e2d\uff0c\u5927\u90e8\u5206\u54c1\u79cd\u5e02\u573a\u826f\u597d\u5904\u4e8e\u589e\u957f\u8d8b\u52bf\uff0c\u5176\u4e2d\u8fbe\u6bd4\u52a0\u7fa4\u916f\u3001\u963f\u54cc\u6c99\u73ed\u548c\u5229\u4f10\u6c99\u73ed\u4e3a\u8fd1\u5e74\u5728\u56fd\u5185\u4e0a\u5e02\u7684\u65b0\u836f\uff0c\u5e02\u573a\u589e\u957f\u7387\u5747\u8d85\u8fc7<\/span>100%\u3002\u6839\u636e\u6c64\u68ee\u8def\u900f\u6570\u636e\u5e93\u7684\u76f8\u5173\u6570\u636e\uff0c\u4e09\u79cd\u65b0\u578b\u6297\u51dd\u836f\u5168\u7403\u5e02\u573a\u9500\u552e\u989d\u53ca\u9884\u6d4b\u89c1\u4e0b\u56fe\uff0c\u4e09\u79cd\u65b0\u578b\u6297\u51dd\u836f\u7531\u4e8e\u9002\u5e94\u75c7\u5341\u5206\u76f8\u540c\uff0c\u6240\u4ee5\u5728\u9500\u552e\u9884\u671f\u4e0a\u5747\u542b\u6709\u4e0d\u540c\u9002\u5e94\u75c7\u7684\u9884\u671f<\/span>(\u975e\u74e3\u819c\u6027\u623f\u98a4\u3001\u5173\u8282\u7f6e\u6362\u672f\u3001\u6df1\u9759\u8109\u8840\u6813\u548c\u80ba\u6813\u585e\u6cbb\u7597<\/span>)[21]<\/sup>\u3002\u5229\u4f10\u6c99\u73ed\u4e0a\u5e02\u6700\u65e9\uff0c\u6240\u4ee5\u5728\u9500\u552e\u4e0a\u5360\u6709\u4f18\u52bf\uff0c\u4f46\u5728\u623f\u98a4\u9002\u5e94\u75c7\u4e2d\uff0c\u8fbe\u6bd4\u52a0\u7fa4\u63a8\u5e7f\u8f83\u65e9\uff0c\u5360\u4f18\u52bf\uff0c\u963f\u54cc\u6c99\u73ed\u867d\u7136\u4e0a\u5e02\u8f83\u665a\uff0c\u4f46\u51fa\u8840\u98ce\u9669\u4f4e\uff0c\u5b89\u5168\u6027\u6700\u597d\uff0c\u5177\u6709\u660e\u663e\u7684\u5e02\u573a\u4f18\u52bf\u3002<\/span><\/span><\/p>\n


<\/p>\n

\"\u65b0\u578b\u53e3\u670d\u6297\u51dd\u8840\u836f\u7269\u5168\u7403\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

\u56fe<\/span>3 <\/span><\/strong>\u5229\u4f10\u6c99\u73ed\u3001\u8fbe\u6bd4\u52a0\u7fa4\u916f\u53ca\u963f\u54cc\u6c99\u73ed\u5168\u7403\u9500\u91cf\u9884\u6d4b<\/span><\/p>\n


<\/p>\n

2017\u5e74<\/span>6\u6708\uff0c\u7f8e\u56fd<\/span>FDA\u4f20\u6765\u559c\u8baf<\/span>\u2014\u2014\u7531<\/span>PortolaPharmaceuticals\u7814\u53d1\u7684\u65b0\u836f\u83b7\u6279\u4e0a\u5e02\u3002\u8fd9\u662f\u76ee\u524d\u5728\u7d27\u6025\u4f4f\u9662\u7684\u6210\u4eba\u60a3\u8005\u4e2d\uff0c\u80fd\u591f\u5728\u4f4f\u9662\u4ee5\u53ca\u540e\u7eed\u9636\u6bb5\uff0c\u957f\u6548\u9884\u9632\u56e0\u8fd0\u52a8\u53d7\u9650\u800c\u51fa\u73b0\u9759\u8109\u8840\u6813\u6813\u585e\u7684\u552f\u4e00\u4e00\u6b3e\u6297\u51dd\u8840\u5242\u3002\u636e\u6c64\u68ee\u8def\u900f\u6570\u636e\u5e93\u9884\u6d4b<\/span>2023\u5e74<\/span>betrixaban\u5168\u7403\u9500\u552e\u91cf\u5c06\u8fbe<\/span>12\u4ebf\u7f8e\u5143<\/span>[22]<\/sup>\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\"\u65b0\u578b\u53e3\u670d\u6297\u51dd\u8840\u836f\u7269\u5168\u7403\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

<\/span>\u56fe<\/span>4 <\/strong>Betrixaban\u5168\u7403\u9500\u552e\u9884\u6d4b\uff08\u767e\u4e07\u7f8e\u5143\uff09<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u65b0\u578b\u53e3\u670d\u6297\u51dd\u8840\u836f\u7269\u7684\u53d1\u5c55\uff0c\u4f7f\u6211\u56fd\u6297\u51dd\u8840\u5e02\u573a\u589e\u957f\u8fc5\u901f\uff0c<\/span>6<\/span>\u5e74\u590d\u5408\u589e\u957f\u7387\u9ad8\u8fbe<\/span>16%<\/span>\u3002\u6837\u672c\u57ce\u5e02<\/span>2015<\/span>\u5e74\u9500\u552e\u989d\u7ea6\u4e3a<\/span>10<\/span>\u4ebf\u5143\uff0c\u5360\u6574\u4e2a\u6297\u8840\u6813\u836f\u7269\u5e02\u573a\u7684<\/span>32%<\/span>\u3002\u6297\u51dd\u8840\u836f\u7269\u4e2d\uff0c\u4f20\u7edf\u54c1\u79cd\u809d\u7d20\u7c7b\u836f\u7269\u4f9d\u7136\u5360\u636e\u5927\u90e8\u5206\u5e02\u573a\u4efd\u989d\u8fbe<\/span>72%<\/span>\u3002\u7eb5\u89c8\u56fd\u5916\u6297\u51dd\u8840\u836f\u7269\u5e02\u573a\uff0c\u65b0\u578b\u51dd\u8840\u56e0\u5b50<\/span>Xa<\/span>\u6291\u5236\u5242\uff08\u6c99\u73ed\u7c7b\u836f\u7269\uff09\u5df2\u9010\u6e10\u6210\u4e3a\u6297\u51dd\u8840\u836f\u7269\u7684\u4e3b\u529b\u519b\uff0c<\/span>2016<\/span>\u5e74\u5229\u4f10\u6c99\u73ed\u53ca\u963f\u54cc\u6c99\u73ed\u5206\u522b\u4f4d\u5c45\u5168\u7403\u836f\u7269\u9500\u552e\u989d<\/span>12<\/span>\u4f4d\uff08<\/span>50<\/span>\u4ebf\u7f8e\u5143\uff09\u53ca<\/span>23<\/span>\u4f4d\uff08<\/span>33.43<\/span>\u4ebf\u7f8e\u5143\uff09\uff0c\u6da8\u5e45\u660e\u663e\uff0c\u76f8\u4fe1\u5728\u6211\u56fd\uff0c\u65b0\u578b\u51dd\u8840\u56e0\u5b50<\/span>Xa<\/span>\u6291\u5236\u5242\u540c\u6837\u4f1a\u9010\u6e10\u53d6\u4ee3\u4f20\u7edf\u7684\u6297\u51dd\u8840\u836f\u7269\uff0c\u5360\u9886\u56fd\u5185\u6297\u51dd\u8840\u5e02\u573a\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u56fd\u5185\u4e0a\u5e02\u7684\u6297\u51dd\u8840\u836f\u7269\u4e3b\u8981\u6709<\/span>14\u79cd\uff0c\u5404\u54c1\u79cd\u76ee\u524d\u751f\u4ea7\u4f01\u4e1a\u4e0d\u591a\u4ec5\u4e3a\u4e2a\u4f4d\u6570\uff0c\u5e02\u573a\u5145\u6ee1\u673a\u9047\u3002\u4f20\u7edf\u6cbb\u7597\u836f\u7269\u7ef4\u751f\u7d20<\/span>K\u62ee\u6297\u5242\u548c\u809d\u7d20\u7c7b\u4ea7\u54c1\u5e02\u573a\u9010\u6e10\u8d8b\u4e8e\u7a33\u5b9a\uff0c\u5728\u7533\u62a5\u751f\u4ea7\u7684\u4f01\u4e1a\u6bd4\u8f83\u5c11\u3002\u800c\u65b0\u578b\u6cbb\u7597\u836f\u7269\u76f4\u63a5\u51dd\u8840\u9176\u6291\u5236\u5242\u548c\u51dd\u8840\u56e0\u5b50<\/span>Xa\u6291\u5236\u5242\u8868\u73b0\u51fa\u5f3a\u5927\u7684\u5e02\u573a\u6d3b\u529b\u548c\u7ade\u4e89\u529b\uff0c\u5728\u7533\u62a5\u4f01\u4e1a\u591a\u8fbe\u4e24\u4f4d\u6570\u4ee5\u4e0a\uff0c\u7279\u522b\u662f\u5229\u4f10\u6c99\u73ed\u5728\u7533\u62a5\u4f01\u4e1a\u591a\u8fbe<\/span>30\u5bb6<\/span>(\u89c1\u4e0b\u8868<\/span>)\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u4ece\u56fd\u5185\u4f01\u4e1a\u7533\u62a5\u89d2\u5ea6\u5ba1\u89c6\uff0c\u65b0\u578b\u51dd\u8840\u56e0\u5b50<\/span>Xa\u6291\u5236\u5242\u4e5f\u5c06\u9010\u6e10\u4ee3\u66ff\u4f20\u7edf\u7684\u6297\u51dd\u8840\u836f\u7269\uff0c\u6210\u4e3a\u56fd\u5185\u6297\u51dd\u8840\u836f\u7269\u7684\u4e3b\u529b\u519b\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u8868<\/span>2 <\/span><\/strong>\u56fd\u5185\u53e3\u670d\u6297\u51dd\u8840\u836f\u7269\u4e0a\u5e02\u53ca\u7533\u62a5\u4f01\u4e1a\u7edf\u8ba1<\/span><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u836f\u7269\u7c7b\u578b<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u836f\u7269\u540d\u79f0<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u56fd\u5185\u751f\u4ea7\u4f01\u4e1a\u4e2a\u6570<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u5728\u7533\u62a5\u4f01\u4e1a\u4e2a\u6570<\/span><\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7ef4\u751f\u7d20<\/span>K<\/span>\u62ee\u6297\u5242<\/span><\/span><\/p>\n<\/td>\n

\n

\u534e\u6cd5\u6797<\/span><\/p>\n<\/td>\n

\n

6<\/span><\/p>\n<\/td>\n

\n

0<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u809d\u7d20\u7c7b<\/span><\/p>\n<\/td>\n

\n

\u4f9d\u8bfa\u809d\u7d20\u94a0<\/span><\/p>\n<\/td>\n

\n

7<\/span><\/p>\n<\/td>\n

\n

7<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4f4e\u5206\u5b50\u809d\u7d20\u94a0<\/span><\/p>\n<\/td>\n

\n

6<\/span><\/p>\n<\/td>\n

\n

0<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u809d\u7d20\u94a0<\/span><\/p>\n<\/td>\n

\n

20<\/span><\/p>\n<\/td>\n

\n

3<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u76f4\u63a5\u51dd\u8840\u9176\u6291\u5236\u5242<\/span><\/p>\n<\/td>\n

\n

\u8fbe\u6bd4\u52a0\u7fa4\u916f<\/span><\/p>\n<\/td>\n

\n

1<\/span><\/p>\n<\/td>\n

\n

16<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u6bd4\u4f10\u5362\u5b9a<\/span><\/p>\n<\/td>\n

\n

2<\/span><\/p>\n<\/td>\n

\n

9<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u963f\u52a0\u66f2\u73ed<\/span><\/p>\n<\/td>\n

\n

2<\/span><\/p>\n<\/td>\n

\n

19<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u51dd\u8840\u56e0\u5b50<\/span>Xa<\/span>\u6291\u5236\u5242<\/span><\/span><\/p>\n<\/td>\n

\n

\u78fa\u8fbe\u809d\u7678\u94a0<\/span><\/p>\n<\/td>\n

\n

1<\/span><\/p>\n<\/td>\n

\n

7<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5229\u4f10\u6c99\u73ed<\/span><\/p>\n<\/td>\n

\n

1<\/span><\/p>\n<\/td>\n

\n

>30<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u963f\u54cc\u6c99\u73ed<\/span><\/p>\n<\/td>\n

\n

1<\/span><\/p>\n<\/td>\n

\n

>20<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/span>
<\/p>\n

\n
\n
\n
\n

4<\/strong><\/span>\u603b\u7ed3\u4e0e\u5c55\u671b<\/strong><\/span><\/span><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/span><\/p>\n

\u968f\u7740\u4e2d\u56fd\u8001\u9f84\u5316\u901f\u5ea6\u52a0\u5feb\uff0c\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u53d1\u75c5\u7387\u5c06\u9010\u5e74\u589e\u52a0\uff0c\u56fd\u5185\u5bf9\u6297\u8840\u6813\u836f\u7269\u7684\u9700\u6c42\u5c06\u4f1a\u8d8a\u6765\u8d8a\u5927\uff0c\u6297\u8840\u5c0f\u677f\u3001\u6297\u51dd\u8840\u548c\u6eb6\u6813\u4e09\u79cd\u4e0d\u540c\u4f5c\u7528\u673a\u5236\u836f\u7269\u4e3a\u4e3b\u8981\u6cbb\u7597\u65b9\u6cd5\u3002\u6297\u51dd\u8840\u836f\u7269\u5e02\u573a\u589e\u901f\u6700\u5feb\uff0c\u968f\u7740\u65b0\u578b\u51dd\u8840\u9176\u6291\u5236\u5242\u548c\u51dd\u8840\u56e0\u5b50<\/span>Xa<\/span>\u6291\u5236\u5242\u53e3\u670d\u836f\u7269\u54c1\u79cd\u7684\u4e0a\u5e02\uff0c\u4f7f\u60a3\u8005\u83b7\u5f97\u4e86\u66f4\u65b9\u4fbf\uff0c\u66f4\u5b89\u5168\u7684\u6cbb\u7597\u9009\u62e9\u3002\u65b0\u578b\u53e3\u670d\u6297\u51dd\u836f\u7684\u5e02\u573a\u89c4\u6a21\u4e0e\u533b\u7597\u53d1\u5c55\u6c34\u5e73\u662f\u5bc6\u4e0d\u53ef\u5206\u7684\uff0c\u4ece\u5e02\u573a\u9884\u6d4b\u53ef\u4ee5\u770b\u51fa\uff0c\u5373\u4f7f\u73b0\u6709\u670d\u7528\u534e\u6cd5\u6797\u7684\u4eba\u7fa4\uff0c\u6709\u4e00\u534a\u670d\u7528\u65b0\u578b\u6297\u51dd\u836f<\/span>(<\/span>\u51dd\u8840\u56e0\u5b50<\/span>Xa<\/span>\u6291\u5236\u5242<\/span>)<\/span>\uff0c\u5176\u5e02\u573a\u89c4\u6a21\u4e5f\u6709<\/span>20<\/span>\u51e0\u4e2a\u4ebf\u3002\u968f\u7740\u533b\u7597\u6c34\u5e73\u7684\u53d1\u5c55\uff0c\u8fd9\u4e2a\u6570\u5b57\u5c06\u4e0d\u65ad\u7684\u6269\u5927\uff0c\u5982\u679c\u8fd9\u7c7b\u836f\u7269\u8fdb\u5165\u533b\u4fdd\uff0c\u5c06\u66f4\u52a0\u6709\u5229\u3002\u56e0\u6b64\uff0c\u4ece\u6211\u56fd\u73b0\u6709\u7684\u7ecf\u6d4e\u53d1\u5c55\u548c\u533b\u7597\u53d1\u5c55\u6765\u770b\uff0c\u5373\u4f7f\u8fbe\u4e0d\u5230\u5982\u53d1\u8fbe\u56fd\u5bb6\u4e00\u6837\u7684\u6297\u51dd\u6c34\u5e73<\/span>(<\/span>\u60a3\u8005\u7684<\/span>50%<\/span>\u4ee5\u4e0a<\/span>)<\/span>\uff0c\u81f3\u5c11\u4e5f\u53ef\u4ee5\u589e\u52a0\u5230<\/span>20-30%<\/span>\uff0c\u90a3\u6574\u4e2a\u53e3\u670d\u6297\u51dd\u8840\u836f\u7269\u5e02\u573a\u4efd\u989d\u5c06\u5448\u500d\u6570\u589e\u957f\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u968f\u7740\u533b\u836f\u79d1\u6280\u7684\u8fc5\u901f\u53d1\u5c55\uff0c\u751f\u7269\u836f\u7269\u7684\u5d1b\u8d77\u673a\u9047\u5df2\u5f00\u59cb\u663e\u73b0\u3002<\/span>2014<\/span>\u5e74\uff0c\u5168\u7403<\/span>10<\/span>\u53ea\u9500\u91cf\u6700\u9ad8\u7684\u836f\u54c1\u5171\u521b\u9020\u4e86<\/span>830<\/span>\u4ebf\u7f8e\u5143\u7684\u5e02\u573a\u4ef7\u503c\uff0c\u5176\u4e2d\u5c31\u6709<\/span>7<\/span>\u53ea\u751f\u7269\u836f\uff0c\u5e02\u503c\u5171\u8ba1<\/span>600<\/span>\u4ebf\u7f8e\u5143\u3002<\/span>PD-1<\/span>\u5355\u514b\u9686\u6297\u4f53\u3001<\/span>CAR-T<\/span>\u57fa\u56e0\u7597\u6cd5\u7684\u9646\u7eed\u4e0a\u5e02\u6269\u5c55\u4e86\u4eba\u7c7b\u5bf9\u6297\u75be\u75c5\u7684\u65b0\u9014\u5f84\u3002\u8fd1\u4e9b\u5e74\u6765\uff0c\u5355\u514b\u9686\u6297\u4f53\u4ea7\u54c1\u4e5f\u51fa\u73b0\u5728\u5728\u6297\u51dd\u8840\u836f\u7269\u7684\u7814\u53d1\u4e2d\uff0c\u4f8b\u5982<\/span>aXIMab<\/span>\u662f\u4e00\u79cd\u9f20\u6297\u4eba<\/span>FXI A3<\/span>\u7ed3\u6784\u57df\u7684\u5355\u514b\u9686\u6297\u4f53\u3002\u7ed9\u4e88\u72d2\u72d2\u9759\u8109\u6ce8\u5c04<\/span>2 mg\u00b7kg-1<\/sup><\/span>\u7684<\/span>aXIMab<\/span>\uff0c\u5728<\/span>10<\/span>\u5929\u5185\u51e0\u4e4e\u80fd\u5b8c\u5168\u6291\u5236\u8840\u6d46<\/span>FXI<\/span>\u6d3b\u6027\uff0c\u5e76\u6291\u5236\u51dd\u8840\u9176\u7684\u5f62\u6210\u548c\u8840\u5c0f\u677f\u7684\u6fc0\u6d3b\uff0c\u51cf\u5c11\u52a8\u9759\u8109\u65c1\u8def\u8840\u6813\u4e2d\u8840\u5c0f\u677f\u6c89\u79ef\u548c\u8840\u6813\u751f\u6210\uff0c\u5e76\u4e14\u4e0d\u589e\u52a0\u51fa\u8840\u65f6\u95f4\uff0c\u5728\u6297\u6813\u6548\u679c\u53ca\u51fa\u8840\u65f6\u95f4\u65b9\u9762\u5747\u4f18\u4e8e<\/span>32 mg\u00b7kg-1<\/sup><\/span>\u7684\u963f\u53f8\u5339\u6797<\/span>[23]<\/sup><\/span>\u3002<\/span>2017<\/span>\u5e74\u4fc4\u52d2\u5188\u5065\u5eb7\u4e0e\u79d1\u5b66\u5927\u5b66\u5df2\u7533\u8bf7\u591a\u9879\u5173\u4e8e<\/span><\/span>aXIMab<\/span>\u7684\u4e13\u5229\uff0c\u6743\u5229\u8981\u6c42\u660e\u786e\u4fdd\u62a4\u4e86<\/span>aXIMab<\/span>\u5355\u514b\u9686\u6297\u4f53\u5e94\u7528\u4e8e\u8840\u6813\u6cbb\u7597\u9886\u57df<\/span>[24]<\/sup><\/span>\u3002<\/span><\/span><\/p>\n


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\u56fe<\/span>5 <\/span><\/strong>\u51dd\u8840\u7ea7\u8054\u53cd\u5e94<\/span><\/p>\n


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\u7efc\u4e0a\u6240\u8ff0\uff0c\u5168\u7403\u65b0\u578b\u6297\u51dd\u8840\u836f\u7269\u7684\u7814\u7a76\u5c42\u6b21\u4e0d\u540c\uff0c\u4f5c\u7528\u4e8e<\/span>FXI<\/span>\u7684\u5355\u514b\u9686\u6297\u4f53\u5f88\u53ef\u80fd\u6210\u4e3a\u5168\u7403\u8840\u6813\u6cbb\u7597\u7684\u53d1\u5c55\u65b9\u5411\uff0c\u672a\u6765\u4e5f\u5c06\u9010\u6e10\u6709\u65b0\u578b\u6297\u8840\u6813\u751f\u7269\u5236\u54c1\u4e0a\u5e02\u3002<\/span><\/span><\/p>\n

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REFERENCES<\/span><\/strong><\/h2>\n

[1] HUM J, SHATZEL J J, JOU J H, et al. Theefficacy and safety of direct oral anticoagulants vs traditional anticoagulantsin cirrhosis [J]. Eur J Haematol, 2017, 98 (4): 393-397.<\/span><\/p>\n

[2] LINZ, JOHNSON M E. Proposed cation-pi mediated binding by factor Xa: a novelenzymatic mechanism for molecular recognition [J]. FEBS Lett, 1995, 370 (1-2):1-5.<\/span><\/p>\n

[3] ADCOCKD M, GOSSELIN R. Direct Oral Anticoagulants (DOACs) in the Laboratory: 2015Review [J]. Thromb Res, 2015, 136 (1): 7-12.<\/span><\/p>\n

[4] KREUTZR. Pharmacodynamic and pharmacokinetic basics of rivaroxaban [J]. Fundam ClinPharmacol, 2012, 26 (1): 27-32.<\/span><\/p>\n

[5] MACKMANN, BECKER R C. DVT: a new era in anticoagulant therapy [J]. Arterioscler ThrombVasc Biol, 2010, 30 (3): 369-371.<\/span><\/p>\n

[6] IEKOM. Dabigatran etexilate, a thrombin inhibitor for the prevention of venousthromboembolism and stroke [J]. Curr Opin Investig Drugs, 2007, 8 (9): 758-768.<\/span><\/p>\n

[7] BAETZB E, SPINLER S A. Dabigatran etexilate: an oral direct thrombin inhibitor forprophylaxis and treatment of thromboembolic diseases [J]. Pharmacotherapy,2008, 28 (11): 1354-1373.<\/span><\/p>\n

[8] BORRISL C. Rivaroxaban, a new, oral, direct factor Xa inhibitor forthromboprophylaxis after major joint arthroplasty [J]. Expert OpinPharmacother, 2009, 10 (6): 1083-1088.<\/span><\/p>\n

[9] SINGERA J, XIANG J, KABRHEL C, et al. Multicenter Trial of Rivaroxaban for EarlyDischarge of Pulmonary Embolism From the Emergency Department (MERCURY PE):Rationale and Design [J]. Acad Emerg Med, 2016, 23 (11): 1280-1286.<\/span><\/p>\n

[10]       LASSEN M R, DAVIDSON B L, GALLUS A, et al. The efficacy andsafety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxisin patients following total knee replacement [J]. J Thromb Haemost, 2007, 5(12): 2368-2375.<\/span><\/p>\n

[11] WONG P C, CRAIN E J, XIN B, et al. Apixaban, an oral, directand highly selective factor Xa inhibitor: in vitro, antithrombotic andantihemostatic studies [J]. J Thromb Haemost, 2008, 6 (5): 820-829.<\/span><\/p>\n

[12] MOORMAN M L, NASH J E, STABI K L. Emergency surgery and traumain patients treated with the new oral anticoagulants: dabigatran, rivaroxaban,and apixaban [J]. J Trauma Acute Care Surg, 2014, 77 (3): 486-494; quiz486-494.<\/span><\/p>\n

[13] ALOTAIBI G, ALSALEH K, WU C, et al. Dabigatran, rivaroxabanand apixaban for extended venous thromboembolism treatment: networkmeta-analysis [J]. Int Angiol, 2014, 33 (4): 301-308.<\/span><\/p>\n

[14] BHANWRA S, AHLUWALIA K. The new factor Xa inhibitor: Apixaban[J]. J Pharmacol Pharmacother, 2014, 5 (1): 12-14.<\/span><\/p>\n

[15] RAMACCIOTTI E, HOPPENSTEADT D, FAREED J. Betrixaban for VTEPrevention in the Medically Ill Population, the APEX Trial [J]. Clin ApplThromb Hemost, 2016, 1076029616683805.<\/span><\/p>\n

[16] THOENES M, MINGUET J, BRAMLAGE K, et al. Betrixaban – the nextdirect factor Xa inhibitor? [J]. Expert Rev Hematol, 2016, 9 (12): 1111-1117.<\/span><\/p>\n

[17] TRAYNOR K. Betrixaban approved as oral VTE preventive [J]. AmJ Health Syst Pharm, 2017, 74 (15): 1118.<\/span><\/p>\n

[18] CAVE B, HOUGH A, ROSENSTEIN R. Betrixaban in Acutely IllMedical Patients [J]. N Engl J Med, 2016, 375 (24): e50.<\/span><\/p>\n

[19] PALLADINO M, MERLI G, THOMSON L. Evaluation of the oral directfactor Xa inhibitor – betrixaban [J]. Expert Opin Investig Drugs, 2013, 22(11): 1465-1472.<\/span><\/p>\n

[20] GIBSON C M, HALABY R, KORJIAN S, et al. The safety andefficacy of full- versus reduced-dose betrixaban in the Acute Medically Ill VTE(Venous Thromboembolism) Prevention With Extended-Duration Betrixaban (APEX)trial [J]. Am Heart J, 2017, 185 93-100.<\/span><\/p>\n

[21] Rivaroxaban, apixaban, dabigatran etexilate [J].Thomsonreuters, 2017, <\/span><\/p>\n

[22] Betrixaban [J]. cortellis, 2017, <\/span><\/p>\n

[23] TUCKER E I, MARZEC U M, WHITE T C, et al. Prevention ofvascular graft occlusion and thrombus-associated thrombin generation byinhibition of factor XI [J]. Blood, 2009, 113 (4): 936-944.<\/span><\/p>\n

[24] GRUBER A. Anti-factor XI monoclonalantibodies and methods of use thereof [J]. PATENT, 2017, US9636399 <\/span><\/p>\n

[25] BANE C E, JR., GAILANI D. Factor XI as a target forantithrombotic therapy [J]. Drug Discov Today, 2014, 19 (9): 1454-1458.<\/span><\/p>\n


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\u521b\u65b0\u836f\u7845\u8c37\u5730\u5e26\u2014\u2014\u6052\u745e\u3001\u590d\u5174\u3001\u8c6a\u68ee\u56e2\u56e2\u5305\u56f4\u4e0b\u7684\u6c5f\u6d59\u6caa<\/a><\/span><\/h2>\n

\u9884\u6d4b\u7b2c\u56db\u6279\u7b26\u5408\u4eff\u5236\u836f\u8d28\u91cf\u548c\u7597\u6548\u4e00\u81f4\u6027\u8bc4\u4ef7\u54c1\u79cd\u2014\u2014\u6052\u745e\u8c6a\u68ee\u5373\u5c06\u4eae\u5251<\/a><\/span><\/h2>\n

\u6052\u745e\/\u4fe1\u8fbe\u2014\u2014\u56fd\u5185PD-1\u7814\u53d1\u8fde\u8fde\u53d7\u632b<\/a><\/span><\/h2>\n

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Not only\u6c2f\u5421\u683c\u96f7\uff0cbut also\u66ff\u683c\u745e\u6d1b \u2014\u2014 \u5341\u5e74\u78e8\u4e00\u5251<\/a><\/span><\/h2>\n

2018\uff0c\u8fd9\u4e2a\u836f\u4e0d\u77e5\u9053\uff0c\u4f60\u5c31OUT\u5566\uff01\uff01\uff01\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187 \u2014\u2014 \u77f3\u836f VS \u6052\u745e<\/a><\/span><\/h2>\n

\u7231\u8f7b\u5962\uff0c\u7231\u751f\u6d3b \u2014\u2014 \u5e74\u7ec8\u77eb\u60c5\u7bc7<\/a><\/span><\/h2>\n

\u8bba\u5b64\u72ec | \u5468\u672b\u8f7b\u677e\u7bc7<\/a><\/span><\/h2>\n

PD-1\u6291\u5236\u5242 \u2014\u2014\u201c\u5239\u90a3\u82b3\u534e\u201d<\/a><\/span><\/h2>\n

\u4e00\u4efd”\u957f\u60c5”\u7684\u6218\u4e66 VS \u591a\u53d1\u6027\u9aa8\u9ad3\u7624<\/a><\/span><\/h2>\n

PD-1\/PD-L1 \u5206\u5206\u949f\u8bfb\u61c2\u514d\u75ab\u6cbb\u7597<\/a><\/span><\/h2>\n

\u5e15\u91d1\u68ee\u4e5f\u6709\u660e\u5929<\/span><\/a><\/h2>\n

CRO\u2014\u75af\u72c2\u635e\u91d1\u7684\u65f6\u4ee3<\/span><\/a><\/h2>\n

HBV\u2014\u2014\u8eb2\u4e0d\u5f00\u7684cccDNA<\/span><\/a><\/h2>\n

WHO IS THE KING IN 2022<\/span><\/a><\/h2>\n

\u4ece\u9776\u5411\u6cbb\u7597\u5230\u7cbe\u51c6\u533b\u7597<\/span><\/a><\/h2>\n

YES \uff0cI DO<\/span><\/a><\/h2>\n

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\u9633\u5149\u4e0b\u7684\u4e00\u81f4\u6027\u8bc4\u4ef7<\/a><\/span><\/h2>\n<\/section>\n<\/section>\n
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\u5fc3\u4f3c\u5e73\u539f\u8d70\u9a6c\uff0c\u6613\u653e\u96be\u6536\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u884c\u821fDrug<\/span><\/p>\n<\/section>\n

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\"\u65b0\u578b\u53e3\u670d\u6297\u51dd\u8840\u836f\u7269\u5168\u7403\u7814\u7a76\u8fdb\u5c55\"<\/p>\n<\/section>\n


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\u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u884c\u821fDrug <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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