{"id":17742,"date":"2018-07-23T01:00:00","date_gmt":"2018-08-08T01:00:47","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/08\/ivosidenib\/"},"modified":"2018-08-08T09:00:49","modified_gmt":"2018-08-08T01:00:49","slug":"ivosidenib","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/17742\/","title":{"rendered":"ivosidenib"},"content":{"rendered":"
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\u70b9\u51fb\u4e0a\u65b9\u7684<\/span> \u884c\u821fDrug \u25b2<\/span> \u6dfb\u52a0\u5173\u6ce8<\/span><\/span><\/p>\n


<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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\u836f\u7269\u540d\u79f0<\/span><\/p>\n<\/td>\n

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ivosidenib<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u836f\u7269\u5236\u5242<\/span><\/p>\n<\/td>\n

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          <\/p>\n

\"ivosidenib\"<\/p>\n<\/td>\n<\/tr>\n

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\u5546\u54c1\u540d\u79f0<\/span><\/p>\n<\/td>\n

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TIBSOVO<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u9002\u5e94\u75c7<\/span><\/p>\n<\/td>\n

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\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u7ed9\u836f\u9014\u5f84<\/span><\/p>\n<\/td>\n

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\u53e3\u670d<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u9776\u70b9<\/span><\/p>\n<\/td>\n

IDH1 gene inhibitor<\/span><\/td>\n<\/tr>\n
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\u836f\u7269\u7279\u70b9<\/span><\/p>\n<\/td>\n

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TIBSOVO\u00ae\u662f\u4e00\u79cdIDH1\u9176\u7684\u53e3\u670d\u9776\u5411\u6291\u5236\u5242\uff0c\u662f\u76ee\u524d\u552f\u4e00\u4e00\u6b3e\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u9488\u5bf9IDH1\u7a81\u53d8\u7684R\/R AML\u7597\u6cd5\u3002\u6b64\u6b21FDA\u6279\u51c6TIBSOVO\u00ae\u7528\u4e8e\u5177\u6709IDH1\u7a81\u53d8\u7684R\/R AML\u60a3\u8005\u662f\u57fa\u4e8e\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u5355\u81c2\u3001\u591a\u4e2d\u5fc3\u3001\u5242\u91cf\u9012\u589e\u548c\u6269\u589e\u8bd5\u9a8cAG120-C-001\u7684\u4e34\u5e8a\u6570\u636e\u3002\u8fd9\u9879\u7814\u7a76\u5305\u542b\u4e86174\u540d\u60a3\u8005\uff0c\u4ed6\u4eec\u4ee5\u6bcf\u65e5500\u6beb\u514bTIBSOVO\u00ae\u7684\u8d77\u59cb\u5242\u91cf\u53e3\u670d\u7ed9\u836f\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u3001\u53d1\u751f\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\u6216\u9700\u8981\u8fdb\u884c\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u8054\u5408\u7684\u5b8c\u5168\u7f13\u89e3\uff08CR\uff09\u548c\u6709\u90e8\u5206\u8840\u6db2\u5b66\u6539\u5584\u7684\u5b8c\u5168\u7f13\u89e3\uff08CRh\uff09\u7387\u3002CRh\u5b9a\u4e49\u4e3a\u9aa8\u9ad3\u4e2d<5\uff05\u7684\u80da\u7ec6\u80de\u6ca1\u6709\u75be\u75c5\u8ff9\u8c61\u4e14\u5916\u5468\u8840\u8ba1\u6570\u90e8\u5206\u6062\u590d\uff08\u8840\u5c0f\u677f> 50,000 \/\u5fae\u5347\u548cANC> 500 \/\u5fae\u5347\uff09\u3002<\/span><\/span><\/p>\n<\/td>\n<\/tr>\n

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\u539f\u7814\u516c\u53f8<\/span><\/p>\n<\/td>\n

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Agios Pharmaceuticals Inc<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u7814\u53d1\u5386\u53f2<\/span><\/p>\n<\/td>\n

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\u5f85\u66f4\u65b0<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u4e0a\u5e02\u65f6\u95f4<\/span><\/p>\n<\/td>\n

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2018<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u56fd\u5185\u4e0a\u5e02\u65f6\u95f4<\/span><\/p>\n<\/td>\n

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\u672a\u4e0a\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u56fd\u5185\u7533\u62a5\u5382\u5bb6<\/span><\/p>\n<\/td>\n

\u65e0<\/span>
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\u539f\u7814\u4e13\u5229<\/span><\/p>\n

\u4fe1\u606f<\/span><\/p>\n<\/td>\n

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\u4e13\u5229\u53f7<\/span><\/p>\n<\/td>\n

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\u5230\u671f\u65e5<\/span><\/p>\n<\/td>\n

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\u4e13\u5229\u540d\u79f0<\/span><\/p>\n<\/td>\n<\/tr>\n

WO-2013107291 <\/span><\/td>\n2033<\/span><\/td>\nTherapeutically active compounds and their methods of use<\/span><\/td>\n<\/tr>\n
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\u5168\u7403\u9500\u552e<\/span><\/p>\n

\u9884\u6d4b<\/span><\/p>\n<\/td>\n

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\"ivosidenib\"<\/p>\n<\/td>\n<\/tr>\n

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  <\/span><\/span>S <\/span>
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 <\/span> W<\/span><\/span> <\/span><\/span><\/p>\n


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 <\/span> <\/span>O<\/span><\/span> <\/span><\/span><\/p>\n


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  T<\/span><\/span> <\/span><\/span><\/span><\/p>\n


<\/p>\n<\/td>\n

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1. \u5168\u7403\u9996\u4e2a\u4e0a\u5e02\u9500\u552e\u7684IDH1\u6291\u5236\u5242<\/span><\/span><\/p>\n

2. \u5b64\u513f\u836f\u5730\u4f4d\uff0c\u653f\u7b56\u4f18\u52bf\u660e\u663e<\/span><\/p>\n

3. \u4e13\u5229\u4fdd\u62a4\u52302033\u5e74<\/span><\/p>\n<\/td>\n<\/tr>\n

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1. \u7f3a\u4e4f\u957f\u671f\u4e34\u5e8a\u5b89\u5168\u6027\u6570\u636e\u652f\u6301<\/span><\/p>\n

2. \u526f\u4f5c\u7528\u5305\u62ec\u5305\u62ec\u75b2\u52b3\uff0836%\uff09\uff0c\u6076\u5fc3\uff0833%\uff09\uff0c\u8179\u6cfb\uff0832%\uff09\uff0c\u53d1\u70ed\uff0827%\uff09\uff0c\u5916\u5468\u6c34\u80bf\uff0826%\uff09\uff0c\u5455\u5410\uff0824%\uff09\uff0c\u767d\u7ec6\u80de\u589e\u591a\uff0822%\uff09\u8d2b\u8840\uff0821%\uff09\uff0c\u54b3\u55fd\uff0821%\uff09\uff0c\u98df\u6b32\u51cf\u9000\uff0821%\uff09\uff0c\u547c\u5438\u56f0\u96be\uff0821%\uff09<\/span>\u53d1\u70ed\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0821%\uff09<\/span><\/p>\n

3. \u53ef\u80fd\u5f15\u8d77QT\u95f4\u671f\u5ef6\u957f\u3001\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\u3001\u8840\u5c0f\u677f\u51cf\u5c11<\/span><\/p>\n<\/td>\n<\/tr>\n

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1.  \u9002\u5e94\u75c7\u5168\u7403\u5e02\u573a\u5bb9\u91cf\u5de8\u5927<\/span><\/p>\n

2. IDH1\u7a81\u53d8\u68c0\u51fa\u7387\u9ad8\u8fbe25%<\/span><\/p>\n

3. DH1\u5728\u80f6\u8d28\u7624\u60a3\u8005\u4e2d\u9ad8\u8fbe80%\u7684<\/span>\u7a81\u53d8<\/span><\/p>\n<\/td>\n<\/tr>\n

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1. \u7f3a\u4e4f\u957f\u671f\u5b89\u5168\u6027\u6570\u636e\u652f\u6301<\/span><\/p>\n

2. \u7ade\u54c1\u8f83\u591a\uff0c\u5982\u5730\u897f\u4ed6\u6ee8\u7b49<\/span><\/p>\n

3. \u521a\u521a\u4e0a\u5e02\uff0c\u533b\u751f\u60a3\u8005\u63a5\u53d7\u7a0b\u5ea6\u672a\u77e5<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u539f\u7814\u5de5\u827a\u8def\u7ebf<\/span><\/p>\n<\/td>\n

\u5f85\u66f4\u65b0<\/span><\/td>\n<\/tr>\n
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\u6742\u8d28\u4fe1\u606f<\/span><\/p>\n<\/td>\n

\u5f85\u66f4\u65b0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n


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ivosidenib<\/span><\/span><\/strong><\/span>\u6c64<\/span><\/strong><\/span>\u68ee<\/span><\/strong><\/span><\/span>\u8def\u900f<\/span><\/span><\/strong>Cortellis<\/span><\/strong>\u62a5\u544a\u514d\u8d39\u4e0b\u8f7d<\/span><\/span><\/strong><\/span><\/p>\n

https:\/\/pan.baidu.com\/s\/1LJYdi6R44JefElBMct2NTQ<\/span><\/p>\n

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<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u5b66\u5982\u9006\u6c34\u884c\u821f\uff0c\u4e0d\u8fdb\u5219\u9000\uff1b<\/span><\/p>\n

\u5fc3\u4f3c\u5e73\u539f\u8d70\u9a6c\uff0c\u6613\u653e\u96be\u6536\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u884c\u821fDrug<\/span><\/p>\n<\/section>\n

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\u6bcf\u65e5\u66f4\u65b0 \u6b22\u8fce\u8ba2\u9605+<\/span><\/p>\n

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<\/p>\n

\"ivosidenib\"<\/p>\n<\/section>\n


<\/p>\n

\u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u884c\u821fDrug <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug \u25b2 \u6dfb\u52a0\u5173\u6ce8 \u836f\u7269\u540d\u79f0 ivosidenib \u836f\u7269\u5236\u5242 […]<\/p>\n","protected":false},"author":1,"featured_media":17743,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/17742"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=17742"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/17742\/revisions"}],"predecessor-version":[{"id":17751,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/17742\/revisions\/17751"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/17743"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=17742"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=17742"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=17742"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}