{"id":18290,"date":"2018-07-16T01:00:00","date_gmt":"2018-08-08T01:03:52","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/08\/%e9%85%b8%e7%a2%b1%e6%80%a7%e5%9c%a8%e5%af%b9%e4%ba%8e%e5%8c%96%e5%90%88%e7%89%a9%e6%88%90%e8%8d%af%e6%80%a7%e7%9a%84%e5%bd%b1%e5%93%8d%ef%bc%88%e4%ba%8c%ef%bc%89\/"},"modified":"2018-08-08T09:03:54","modified_gmt":"2018-08-08T01:03:54","slug":"%e9%85%b8%e7%a2%b1%e6%80%a7%e5%9c%a8%e5%af%b9%e4%ba%8e%e5%8c%96%e5%90%88%e7%89%a9%e6%88%90%e8%8d%af%e6%80%a7%e7%9a%84%e5%bd%b1%e5%93%8d%ef%bc%88%e4%ba%8c%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/18290\/","title":{"rendered":"\u9178\u78b1\u6027\u5728\u5bf9\u4e8e\u5316\u5408\u7269\u6210\u836f\u6027\u7684\u5f71\u54cd\uff08\u4e8c\uff09"},"content":{"rendered":"
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\u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug \u25b2<\/span> \u6dfb\u52a0\u5173\u6ce8<\/span><\/span><\/p>\n

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\u5916\u6392\u673a\u5236<\/strong><\/span><\/p>\n


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<\/span><\/p>\n

hERG\u6bd2\u6027<\/strong><\/span><\/p>\n


<\/strong><\/span><\/p>\n

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<\/span><\/p>\n

\u78f7\u8102\u8d28\u75c5(Phospholipidosis)<\/strong><\/span><\/p>\n


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\u7814\u7a76\u8868\u660e\u9633\u79bb\u5b50\u4e24\u6027\u7269\u8d28\uff08cationicamphiphiles\uff09\u80fd\u591f\u5f15\u8d77\u7ec6\u80de\u5185\u78f7\u8102\u8d28\u4f53\u8fc7\u591a\u5bfc\u81f4\u78f7\u8102\u8d28\u75c5\u3002\u4f46\u8fd9\u79cd\u836f\u7269\u526f\u4f5c\u7528\u662f\u53ef\u63a7\u7684\uff0c\u53ef\u9006\u7684\u3002\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u603b\u7ed3\u51fa\u5404\u79cd\u89c4\u5f8b\u6765\u9884\u6d4b\u836f\u7269\u662f\u5426\u4f1a\u6709\u4ea7\u751f\u78f7\u8102\u8d28\u75c5\u7684\u98ce\u9669\uff0c\u73b0\u4eca\u7684\u666e\u904d\u89c4\u5f8b\u4e3b\u8981\u96c6\u4e2d\u5728\u8102\u6eb6\u6027\u548c\u78b1\u6027\u57fa\u56e2\u7684PKa\u4e24\u4e2a\u53c2\u6570\u4e0a\u9762\uff1a\u5f53(ClogP)2<\/sup> + (calculatedbasic pKa)2<\/sup> \u226550\u65f6\uff0c\u53ea\u8981ClogP> 2 \u548c pKa > 6.\u5c31\u4f1a\u4ea7\u751f\u78f7\u8102\u8d28\u75c5\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u7ebf\u7c92\u4f53\u529f\u80fd\u7d0a\u4e71<\/strong><\/span><\/p>\n


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\u6e05\u9664\u7387\uff0c\u4ee3\u8c22\u548cP450\u9176\u7cfb<\/strong><\/span><\/p>\n


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\u5927\u591a\u6570\u836f\u7269\u4e3b\u8981\u901a\u8fc7\u7ec6\u80de\u8272\u7d20P450\u9176\u7cfb\u4e2d\u76841A2, 2C9, 2C19,2D6 \u548c3A4\u4e94\u4e2a\u4e9a\u578b\u4ee3\u8c22\u3002\u82e5\u836f\u7269\u662f\u901a\u8fc7\u9176\u7cfb\u4e2d2C9\u548c 2D6\u4e24\u79cd\u4e9a\u578b\u4ee3\u8c22\u65f6\uff0c\u8fd9\u4e24\u79cd\u4e9a\u578b\u53d7\u751f\u7406\u6761\u4ef6\u4e0b\u5316\u5408\u7269\u7535\u8377\u72b6\u6001\u7684\u5f71\u54cd\u8f83\u5927\uff0c\u8981\u5c24\u4e3a\u5f15\u8d77\u91cd\u89c6\u3002<\/span><\/p>\n


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\u53c2\u8003\u6587\u732e\uff1aChem. Soc. Rev., 2013, 42,485–496<\/span><\/p>\n


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\u58f0\u660e\uff1a\u8f6c\u8f7d\u8bf7\u52a1\u5fc5\u6ce8\u660e\u672c\u6587\u6765\u6e90\u53ca\u4f5c\u8005\u3002<\/strong><\/p>\n

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\u4f5c\u8005\u6587\u7ae0\u63a8\u8350\uff1a<\/span><\/section>\n

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\u7ed3\u6838\u75c5\u7684\u4e34\u5e8a\u6cbb\u7597\u73b0\u72b6<\/span><\/a><\/h2>\n

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\u5171\u4ef7\u7ed3\u5408\u836f\u7269\u77e5\u591a\u5c11\uff08\u4e8c\uff09<\/a><\/span><\/h2>\n

\u5171\u4ef7\u7ed3\u5408\u836f\u7269\u77e5\u591a\u5c11\uff08\u4e00\uff09<\/a><\/span><\/h2>\n

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\u5b66\u5982\u9006\u6c34\u884c\u821f\uff0c\u4e0d\u8fdb\u5219\u9000\uff1b<\/span>
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\u5fc3\u4f3c\u5e73\u539f\u8d70\u9a6c\uff0c\u6613\u653e\u96be\u6536\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u884c\u821fDrug<\/span><\/p>\n<\/section>\n

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\u6bcf\u65e5\u66f4\u65b0 \u6b22\u8fce\u8ba2\u9605+<\/span><\/p>\n

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\"\u9178\u78b1\u6027\u5728\u5bf9\u4e8e\u5316\u5408\u7269\u6210\u836f\u6027\u7684\u5f71\u54cd\uff08\u4e8c\uff09\"<\/p>\n<\/section>\n


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\u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n


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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u884c\u821fDrug <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug \u25b2 \u6dfb\u52a0\u5173\u6ce8 \u5316\u5408\u7269\u9178\u78b1\u6027\u5bf9\u4e8e\u6210\u836f\u6027\u7684\u5f71\u54cd\uff0c\u5728\u4e0a\u8282\u77ed\u6587 […]<\/p>\n","protected":false},"author":1,"featured_media":18291,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/18290"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=18290"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/18290\/revisions"}],"predecessor-version":[{"id":18298,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/18290\/revisions\/18298"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/18291"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=18290"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=18290"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=18290"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}