{"id":18299,"date":"2018-07-16T01:00:00","date_gmt":"2018-08-08T01:03:56","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/08\/acotiamide-hydrochloride-%e9%98%bf%e8%80%83%e6%9b%bf%e8%83%ba\/"},"modified":"2018-08-08T09:03:58","modified_gmt":"2018-08-08T01:03:58","slug":"acotiamide-hydrochloride-%e9%98%bf%e8%80%83%e6%9b%bf%e8%83%ba","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/18299\/","title":{"rendered":"acotiamide hydrochloride \u963f\u8003\u66ff\u80fa"},"content":{"rendered":"
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\u70b9\u51fb\u4e0a\u65b9\u7684<\/span> \u884c\u821fDrug \u25b2<\/span> \u6dfb\u52a0\u5173\u6ce8<\/span><\/span><\/p>\n


<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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\u836f\u7269\u540d\u79f0<\/span><\/p>\n<\/td>\n

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<\/span>acotiamide hydrochloride \u963f\u8003\u66ff\u80fa<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u836f\u7269\u7ed3\u6784<\/span><\/p>\n<\/td>\n

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          <\/p>\n

\"acotiamide<\/p>\n<\/td>\n<\/tr>\n

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\u5546\u54c1\u540d\u79f0<\/span><\/p>\n<\/td>\n

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Acofide<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u9002\u5e94\u75c7<\/span><\/p>\n<\/td>\n

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\u9002\u7528\u4e8e\u6539\u5584\u529f\u80fd\u6027\u6d88\u5316\u4e0d\u826f\u5f15\u8d77\u7684\u9910\u540e\u8179\u80c0\u611f\u3001\u4e0a\u8179\u90e8\u9971\u80c0\u611f\u4ee5\u53ca\u8fc7\u65e9\u9971\u98df\u611f<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u7ed9\u836f\u9014\u5f84<\/span><\/p>\n<\/td>\n

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\u53e3\u670d<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u9776\u70b9<\/span><\/p>\n<\/td>\n

Acetylcholinesteraseinhibitor<\/span><\/td>\n<\/tr>\n
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\u836f\u7269\u7279\u70b9<\/span><\/p>\n<\/td>\n

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\u76d0\u9178\u963f\u8003\u66ff\u80fa\u662f\u4e00\u79cd\u65b0\u578b\u9009\u62e9\u6027\u4e59\u9170\u80c6\u78b1\u916f\u9176<\/span>(AChE)\u6291\u5236\u5242\u3002\u4e59\u9170\u80c6\u78b1\u662f\u4e00\u79cd\u91cd\u8981\u7684\u8c03\u8282\u80c3\u80a0\u8fd0\u52a8\u7684\u795e\u7ecf\u9012\u8d28\u3002\u963f\u8003\u66ff\u80fa\u901a\u8fc7\u6291\u5236\u4e59\u9170\u80c6\u78b1\u7684\u964d\u89e3\uff0c\u6539\u5584\u53d7\u635f\u7684\u80c3\u52a8\u529b\u4e0e\u5ef6\u8fdf\u7684\u80c3\u6392\u7a7a\uff0c\u56e0\u6b64\u6539\u5584\u529f\u80fd\u6027\u6d88\u5316\u4e0d\u826f\u7684\u75c7\u72b6\u3002<\/span><\/span><\/p>\n<\/td>\n<\/tr>\n

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\u539f\u7814\u516c\u53f8<\/span><\/p>\n<\/td>\n

Zeria PharmaceuticalCo Ltd<\/span><\/td>\n<\/tr>\n
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\u7814\u53d1\u5386\u53f2<\/span><\/p>\n<\/td>\n

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\u5f85\u66f4\u65b0<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u4e0a\u5e02\u65f6\u95f4<\/span><\/p>\n<\/td>\n

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2013<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u56fd\u5185\u4e0a\u5e02\u65f6\u95f4<\/span><\/p>\n<\/td>\n

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\u672a\u4e0a\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u56fd\u5185\u7533\u62a5\u5382\u5bb6<\/span><\/p>\n<\/td>\n

\u65e0<\/span>
<\/td>\n<\/tr>\n
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\u539f\u7814\u4e13\u5229<\/span><\/p>\n

\u4fe1\u606f<\/span><\/p>\n<\/td>\n

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\u4e13\u5229\u53f7<\/span><\/p>\n<\/td>\n

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\u5230\u671f\u65e5<\/span><\/p>\n<\/td>\n

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\u4e13\u5229\u540d\u79f0<\/span><\/p>\n<\/td>\n<\/tr>\n

WO-09636619<\/span><\/td>\n2016<\/span><\/td>\nAminothiazolederivatives, drug containing the same and intermediate in the production of the compounds.<\/span><\/td>\n<\/tr>\n
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\u5168\u7403\u9500\u552e<\/span><\/p>\n

\u9884\u6d4b<\/span><\/p>\n<\/td>\n

\"acotiamide<\/td>\n<\/tr>\n
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<\/p>\n


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<\/p>\n<\/td>\n

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1. \u529f\u80fd\u6027\u6d88\u5316\u4e0d\u826ffirst-in-class\u836f\u7269<\/span><\/p>\n

2. \u5728\u540c\u4e00\u8bd5\u9a8c\u4e2d\uff0c\u6d88\u9664FD\uff08\u9910\u540e\u9971\u8179\u3001\u65e9\u671f\u9971\u8179\u548c\u4e0a\u8179\u80c0\uff09\u4e09\u79cd\u996e\u98df\u76f8\u5173\u75c7\u72b6\u7684\u5e94\u7b54\u7387\u4e3a 15.3%<\/span><\/p>\n

3. \u672a\u53d1\u73b0\u660e\u663e\u7684\u5fc3\u8840\u7ba1\u526f\u4f5c\u7528<\/span><\/p>\n<\/td>\n<\/tr>\n

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1. \u4e00\u5929\u4e09\u6b21\u7ed9\u836f\uff0c\u5fc5\u987b\u996d\u524d\u7ed9\u836f<\/span><\/p>\n

2. \u5e38\u89c1\u7684\u526f\u4f5c\u7528\u5305\u62ec\u80a0\u80c3\u6c14\u80c0\u3001\u5934\u75db\u3001\u4fbf\u79d8\u3001\u8179\u6cfb\u548c\u5473\u89c9\u969c\u788d\u7b49<\/span><\/p>\n

3. \u76ee\u524d\u53ea\u5728\u65e5\u672c\u83b7\u6279<\/span><\/p>\n<\/td>\n<\/tr>\n

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1.  FD\u662f\u6700\u5e38\u89c1\u7684\u80c3\u80a0\u75be\u75c5\u4e4b\u4e00\uff0c\u5168\u7403\u5e02\u573a\u5bb9\u91cf\u8f83\u5927<\/span><\/span><\/p>\n

2. FD\u662f\u4e00\u79cd\u5bb9\u6613\u590d\u53d1\u7684\u75be\u75c5\uff0c\u6bcf\u5e74\u7ea6\u670950%\u7684\u60a3\u8005\u75c7\u72b6\u590d\u53d1<\/span><\/p>\n

3. \u7ade\u54c1\uff08\u8d28\u5b50\u6cf5\u6291\u5236\u5242\uff09\u8f83\u591a\uff0c\u5e02\u573a\u7ade\u4e89\u6fc0\u70c8<\/span><\/p>\n<\/td>\n<\/tr>\n

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1. \u7f8e\u56fd\u53ca\u6b27\u6d32\u672a\u6536\u6279\u51c6<\/span><\/p>\n

2. \u7ade\u54c1\u8f83\u591a\uff0c\u5e02\u573a\u7ade\u4e89\u6fc0\u70c8<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u539f\u7814\u5de5\u827a\u8def\u7ebf<\/span><\/p>\n<\/td>\n

\u5f85\u66f4\u65b0<\/span><\/td>\n<\/tr>\n
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\u6742\u8d28\u4fe1\u606f<\/span><\/p>\n<\/td>\n

\u5f85\u66f4\u65b0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n


<\/p>\n

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acotiamide hydrochloride<\/span><\/strong><\/span><\/span>\u6c64<\/span><\/strong><\/span>\u68ee<\/span><\/strong><\/span><\/span>\u8def\u900f<\/span><\/strong>Cortellis<\/span><\/strong>\u62a5\u544a\u514d\u8d39\u4e0b\u8f7d<\/span><\/strong><\/span><\/p>\n

https:\/\/pan.baidu.com\/s\/1RYk8L9Cr45s03lqmu68NRw<\/span><\/p>\n

<\/span><\/p>\n

<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u5b66\u5982\u9006\u6c34\u884c\u821f\uff0c\u4e0d\u8fdb\u5219\u9000\uff1b<\/span><\/p>\n

\u5fc3\u4f3c\u5e73\u539f\u8d70\u9a6c\uff0c\u6613\u653e\u96be\u6536\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u884c\u821fDrug<\/span><\/p>\n<\/section>\n

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\u6bcf\u65e5\u66f4\u65b0 \u6b22\u8fce\u8ba2\u9605+<\/span><\/p>\n

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<\/p>\n

\"acotiamide<\/p>\n<\/section>\n


<\/p>\n

\u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u884c\u821fDrug <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug \u25b2 \u6dfb\u52a0\u5173\u6ce8 \u836f\u7269\u540d\u79f0 acotiamide hydr […]<\/p>\n","protected":false},"author":1,"featured_media":18300,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/18299"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=18299"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/18299\/revisions"}],"predecessor-version":[{"id":18308,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/18299\/revisions\/18308"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/18300"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=18299"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=18299"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=18299"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}