{"id":18541,"date":"2018-07-11T01:00:00","date_gmt":"2018-08-08T01:05:27","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/08\/ambrisentan-%e5%ae%89%e7%ab%8b%e7%94%9f%e5%9d%a6%e7%89%87\/"},"modified":"2018-08-08T09:05:30","modified_gmt":"2018-08-08T01:05:30","slug":"ambrisentan-%e5%ae%89%e7%ab%8b%e7%94%9f%e5%9d%a6%e7%89%87","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/18541\/","title":{"rendered":"Ambrisentan \u5b89\u7acb\u751f\u5766\u7247"},"content":{"rendered":"
\n

\u70b9\u51fb\u4e0a\u65b9\u7684<\/span> \u884c\u821fDrug \u25b2<\/span> \u6dfb\u52a0\u5173\u6ce8<\/span><\/span><\/p>\n


<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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\u836f\u7269\u540d\u79f0<\/span><\/p>\n<\/td>\n

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Ambrisentan <\/span>\u5b89\u7acb\u751f\u5766\u7247<\/span><\/p>\n

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<\/p>\n<\/td>\n<\/tr>\n

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\u836f\u7269\u5236\u5242<\/span><\/p>\n<\/td>\n

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         <\/p>\n

\"Ambrisentan<\/p>\n<\/td>\n<\/tr>\n

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\u5546\u54c1\u540d\u79f0<\/span><\/p>\n<\/td>\n

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Volibris  <\/span>\u51e1\u745e\u514b<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u9002\u5e94\u75c7<\/span><\/p>\n<\/td>\n

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\u9002\u7528\u4e8e\u6cbb\u7597\u6709WHO II\u7ea7\u6216III\u7ea7\u75c7\u72b6\u7684\u80ba\u52a8\u8109\u9ad8\u538b\u60a3\u8005\uff08WHO\u7ec41\uff09\uff0c\u7528\u4ee5\u6539\u5584\u8fd0\u52a8\u80fd\u529b\u548c\u5ef6\u7f13\u4e34\u5e8a\u6076\u5316\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u7ed9\u836f\u9014\u5f84<\/span><\/p>\n<\/td>\n

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\u53e3\u670d<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u9776\u70b9<\/span><\/p>\n<\/td>\n

Endothelin ET-A receptor antagonist<\/span><\/td>\n<\/tr>\n
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\u836f\u7269\u7279\u70b9<\/span><\/p>\n<\/td>\n

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\u5b89\u7acb\u751f\u5766\u662f\u4e00\u79cd\u4e0eETA\u9ad8\u5ea6\u7ed3\u5408\uff08Ki=0.011 nM\uff09\u7684\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u4e0eETB\u76f8\u6bd4\u5bf9\uff0cETA\u6709\u9ad8\u9009\u62e9\u6027\uff08>4000\u500d\uff09\u3002\u5185\u76ae\u7d20-1\uff08ET-1\uff09\u662f\u4e00\u79cd\u6709\u6548\u7684\u81ea\u5206\u6ccc\u548c\u65c1\u5206\u6ccc\u80bd\u3002\u4e24\u79cd\u53d7\u4f53\u4e9a\u578b\uff08ETA\u548cETB\uff09\u5171\u540c\u8c03\u8282ET-1\u5728\u8840\u7ba1\u5e73\u6ed1\u808c\u548c\u5185\u76ae\u7ec6\u80de\u4e2d\u7684\u4f5c\u7528\u3002ETA\u7684\u4e3b\u8981\u4f5c\u7528\u662f\u8840\u7ba1\u6536\u7f29\u548c\u7ec6\u80de\u589e\u6b96\uff0c\u800cETB\u7684\u4e3b\u8981\u4f5c\u7528\u662f\u8840\u7ba1\u8212\u5f20\u3001\u6291\u5236\u589e\u6b96\u3001\u4ee5\u53ca\u6e05\u9664ET-1\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u539f\u7814\u516c\u53f8<\/span><\/p>\n<\/td>\n

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GlaxoSmithKline plc\uff08\u539f\u7814\u516c\u53f8\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u7814\u53d1\u5386\u53f2<\/span><\/p>\n<\/td>\n

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\u5f85\u66f4\u65b0<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u4e0a\u5e02\u65f6\u95f4<\/span><\/p>\n<\/td>\n

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2007<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u56fd\u5185\u4e0a\u5e02\u65f6\u95f4<\/span><\/p>\n<\/td>\n

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\u5df2\u4e0a\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u56fd\u5185\u7533\u62a5\u5382\u5bb6<\/span><\/p>\n<\/td>\n

\u6b63\u5927\u5929\u6674\u836f\u4e1a\u96c6\u56e2\u80a1\u4efd\u6709\u9650\u516c\u53f8\u3001\u6c5f\u82cf\u8c6a\u68ee\u836f\u4e1a\u96c6\u56e2\u6709\u9650\u516c\u53f8\u3001\u5317\u4eac\u5609\u6797\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\u3001\u6d59\u6c5f\u534e\u6d77\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8<\/span><\/td>\n<\/tr>\n
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\u539f\u7814\u4e13\u5229<\/span><\/p>\n

\u4fe1\u606f<\/span><\/p>\n<\/td>\n

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\u4e13\u5229\u53f7<\/span><\/p>\n<\/td>\n

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\u5230\u671f\u65e5<\/span><\/p>\n<\/td>\n

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\u4e13\u5229\u540d\u79f0<\/span><\/p>\n<\/td>\n<\/tr>\n

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WO-09425442 <\/span><\/p>\n<\/td>\n

2014<\/span><\/td>\n\n

3-(Hetero)aryl carboxylic acid derivatives, methods of preparing them and intermediates used in their preparation<\/span><\/p>\n<\/td>\n<\/tr>\n

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\u5168\u7403\u9500\u552e<\/span><\/p>\n

\u9884\u6d4b<\/span><\/p>\n<\/td>\n

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\"Ambrisentan<\/p>\n<\/td>\n<\/tr>\n

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<\/span><\/p>\n

 <\/span><\/p>\n

  <\/span><\/span>S <\/span>
<\/p>\n


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 <\/span> W<\/span><\/span> <\/span><\/span><\/p>\n


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<\/p>\n

 <\/span> <\/span>O<\/span><\/span> <\/span><\/span><\/p>\n


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  T<\/span><\/span> <\/span><\/span><\/span><\/p>\n


<\/p>\n<\/td>\n

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1. \u6bcf\u5929\u53e3\u670d\u7528\u836f\u4e00\u6b21\uff0c\u7ed9\u836f\u65b9\u4fbf<\/span><\/p>\n

2. \u809d\u810f\u5b89\u5168\u6027\u8f83\u9ad8<\/span><\/p>\n

3. \u6709\u6548\u63d0\u9ad8II\u7c7b\u548cIII\u7c7b\u60a3\u8005\u7684\u8fd0\u52a8\u80fd\u529b\u3001\u5ef6\u7f13\u4e34\u5e8a\u6076\u5316<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1. \u5b55\u5987\u7981\u7528<\/span><\/p>\n

2. \u5176\u4ed6\u5e38\u89c1\u7684\u526f\u4f5c\u7528\u5305\u62ec\u9f3b\u585e\uff084%\uff09\u3001\u9f3b\u7aa6\u708e\uff083%\uff09\u548c\u8840\u7ea2\u86cb\u767d\u6c34\u5e73\u964d\u4f4e<\/span><\/p>\n

3. \u7f8e\u56fd\u4e13\u5229\u4fdd\u62a4\u52302018\u5e74<\/span><\/p>\n<\/td>\n<\/tr>\n

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1. \u80ba\u52a8\u8109\u9ad8\u538b\u5168\u7403\u5e02\u573a\u5bb9\u91cf\u8f83\u5927<\/span><\/p>\n

2. \u4e2d\u56fd\u5e02\u573a\u524d\u666f\u8f83\u597d<\/span><\/p>\n

<\/span>
<\/p>\n<\/td>\n<\/tr>\n

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1. \u4e13\u5229\u5230\u671f\uff0c\u4eff\u5236\u836f\u8fdb\u5165<\/span><\/p>\n

2. \u7ade\u54c1UpTravi\uff0c\u4e00\u79cd\u65b0\u578b\u53e3\u670d\u975e\u753e\u4f53\u7c7b\u836f\u7269\uff0c\u4e34\u5e8a\u6548\u679c\u8f83\u597d<\/span><\/p>\n

3. \u53e3\u670dPDE5\u6291\u5236\u5242\uff0c\u5982ReviTo\u3001AdCurCA\uff0c\u4f9d\u7136\u662fII\u7c7b\u6216III PH.\u7684\u9996\u9009\u836f\u7269<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u539f\u7814\u5de5\u827a\u8def\u7ebf<\/span><\/p>\n<\/td>\n

\u5f85\u66f4\u65b0<\/span><\/td>\n<\/tr>\n
\n

\u6742\u8d28\u4fe1\u606f<\/span><\/p>\n<\/td>\n

\u5f85\u66f4\u65b0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n


<\/p>\n

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<\/span><\/strong><\/p>\n

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Ambrisentan<\/span><\/span><\/strong><\/span>\u6c64<\/span><\/strong><\/span>\u68ee<\/span><\/strong><\/span><\/span>\u8def\u900f<\/span><\/span><\/strong>Cortellis<\/span><\/strong>\u62a5\u544a\u514d\u8d39\u4e0b\u8f7d<\/span><\/span><\/strong><\/span><\/p>\n

<\/span><\/p>\n

https:\/\/pan.baidu.com\/s\/1kvkOQ8C8dKLjU6LAJ8xwEg<\/span><\/p>\n

<\/span><\/p>\n

<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u5b66\u5982\u9006\u6c34\u884c\u821f\uff0c\u4e0d\u8fdb\u5219\u9000\uff1b<\/span><\/p>\n

\u5fc3\u4f3c\u5e73\u539f\u8d70\u9a6c\uff0c\u6613\u653e\u96be\u6536\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u884c\u821fDrug<\/span><\/p>\n<\/section>\n

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\u6bcf\u65e5\u66f4\u65b0 \u6b22\u8fce\u8ba2\u9605+<\/span><\/p>\n

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<\/p>\n

\"Ambrisentan<\/p>\n<\/section>\n


<\/p>\n

\u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u884c\u821fDrug <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug \u25b2 \u6dfb\u52a0\u5173\u6ce8 \u836f\u7269\u540d\u79f0 Ambrisentan&nbs […]<\/p>\n","protected":false},"author":1,"featured_media":18542,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/18541"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=18541"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/18541\/revisions"}],"predecessor-version":[{"id":18550,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/18541\/revisions\/18550"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/18542"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=18541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=18541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=18541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}