{"id":18604,"date":"2018-07-30T01:00:00","date_gmt":"2018-08-08T01:05:46","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/08\/%e5%b9%b2%e8%b4%a7%e4%bd%90%e5%89%82%e6%b4%bb%e6%80%a7%e7%9a%84%e7%9b%b8%e5%85%b3%e5%9b%a0%e7%b4%a0%ef%bc%9a%e8%8e%b7%e6%89%b9%e7%96%ab%e8%8b%97%e4%b9%8b%e4%bd%90%e5%89%82%e7%bb%bc%e8%bf%b0\/"},"modified":"2018-08-08T09:05:48","modified_gmt":"2018-08-08T01:05:48","slug":"%e5%b9%b2%e8%b4%a7%e4%bd%90%e5%89%82%e6%b4%bb%e6%80%a7%e7%9a%84%e7%9b%b8%e5%85%b3%e5%9b%a0%e7%b4%a0%ef%bc%9a%e8%8e%b7%e6%89%b9%e7%96%ab%e8%8b%97%e4%b9%8b%e4%bd%90%e5%89%82%e7%bb%bc%e8%bf%b0","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/18604\/","title":{"rendered":"\u5e72\u8d27|\u4f50\u5242\u6d3b\u6027\u7684\u76f8\u5173\u56e0\u7d20\uff1a\u83b7\u6279\u75ab\u82d7\u4e4b\u4f50\u5242\u7efc\u8ff0"},"content":{"rendered":"
\n
\n

<\/span><\/h1>\n
\n
\n
\n
\n
<\/section>\n<\/section>\n
\n
\n
<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n

\u6458\u8981<\/strong><\/span><\/p>\n

\u5728\u7ecf\u5386\u4e86\u51e0\u5341\u5e74\u7684\u7f13\u6162\u8fdb\u5c55\u540e\uff0c\u6700\u8fd1\u51e0\u5e74\u5185\u4f50\u5242\u75ab\u82d7\u7684\u5f00\u53d1\u7684\u8fc5\u901f\u53d1\u5c55\uff0c\u5e76\u5df2\u7ecf\u4f5c\u4e3a\u4eba\u7528\u75ab\u82d7\u88ab\u6279\u51c6\u3002\u8fd9\u4e9b\u4f50\u5242\u542b\u4e0d\u540c\u7684\u7ec4\u5206\uff0c\u4f8b\u5982\u94dd\u76d0\uff0c\u4e73\u5242\uff08\u5982MF59\u548cAS03\uff09\uff0cToll\u6837\u53d7\u4f53\uff08TLR\uff09\u6fc0\u52a8\u5242\uff08\u5982AS04\u4e2d\u90a3\u6837\u5438\u9644\u5728\u94dd\u76d0\u4e0a\u7684CpG\u6216\u5355\u78f7\u9170\u8102\u8d28A\uff08MPL\uff09\uff09\u6216\u514d\u75ab\u589e\u5f3a\u5242\u7684\u7ec4\u5408\uff08AS01\u4e2d\u7684QS-21\u548cMPL\uff09\u3002\u629b\u5f00\u5b83\u4eec\u5404\u81ea\u72ec\u7279\u7684\u7279\u5f81\u4e0d\u8c08\uff0c\u5927\u591a\u6570\u4f50\u5242\u5177\u6709\u4e00\u4e9b\u76f8\u540c\u7684\u5173\u952e\u7279\u5f81\u3002\u4f8b\u5982\uff0c\u5b83\u4eec\u8bf1\u5bfc\u5148\u5929\u514d\u75ab\u7684\u65e9\u671f\u6d3b\u5316\uff08\u5c3d\u7ba1\u6d3b\u5316\u6c34\u5e73\u4e0d\u540c\uff09\uff0c\u800c\u5148\u5929\u514d\u75ab\u4f1a\u8fdb\u4e00\u6b65\u8f6c\u5316\u4e3a\u66f4\u9ad8\u7684\u5bf9\u75ab\u82d7\u6297\u539f\u7684\u6297\u4f53\u548c\u7ec6\u80de\u53cd\u5e94\u3002\u6b64\u5916\uff0c\u5927\u591a\u6570\u8fd9\u4e9b\u4f50\u5242\uff08\u4f8b\u5982MF59\u3001AS03\u3001AS04\uff09\u660e\u663e\u8bf1\u5bfc\u66f4\u5e7f\u6cdb\u7684\u9002\u5e94\u6027\u53cd\u5e94\uff0c\u80fd\u591f\u63d0\u4f9b\u9488\u5bf9\u4f8b\u5982\u6d41\u611f\u75c5\u6bd2\u7684\u5f02\u6e90\u53d8\u4f53\uff08MF59\u3001AS03\uff09\uff0c\u6216\u9488\u5bf9\u672a\u5305\u542b\u5728\u4eba\u4e73\u5934\u7624\u75c5\u75ab\u82d7\u4e2d\u7684\u4eba\u4e73\u5934\u7624\u75c5\u6bd2\u682a\u7684\u4fdd\u62a4\uff08AS04\uff09\u3002\u6700\u540e\uff0c\u5982MF59\u6216AS03\u4f50\u5242\u6d41\u611f\u75ab\u82d7\u548cAS01\u4f50\u5242\u5e26\u72b6\u75b1\u75b9\u75ab\u82d7\u6240\u793a\uff0c\u4f7f\u7528\u67d0\u4e9b\u4f50\u5242\u6709\u52a9\u4e8e\u663e\u7740\u589e\u5f3a\u90a3\u4e9b\u5bf9\u611f\u67d3\u548c\u75ab\u82d7\u63a5\u79cd\u7684\u514d\u75ab\u53cd\u5e94\u51cf\u5f31\u7684\u8001\u5e74\u4eba\u7684\u514d\u75ab\u5e94\u7b54\uff0c\u5e76\u4e14\u63d0\u9ad8\u75ab\u82d7\u7684\u6548\u4ef7\u548c\u6709\u6548\u6027\u3002\u8fd9\u4e9b\u7ed3\u679c\u8fde\u540c\u4f50\u5242\u75ab\u82d7\u5408\u683c\u7684\u5b89\u5168\u6027\u8bb0\u5f55\u4e00\u8d77\uff0c\u4e3a\u9488\u5bf9\u6781\u7aef\u5e74\u9f84\uff0c\u4ee5\u53ca\u9488\u5bf9\u9ad8\u53d1\u75c5\u7387\u3001\u6b7b\u4ea1\u7387\u611f\u67d3\u7684\u65b0\u578b\u75ab\u82d7\u7684\u5f00\u53d1\u94fa\u5e73\u4e86\u9053\u8def\u3002\u5728\u672c\u6587\u4e2d\uff0c\u6211\u4eec\u901a\u8fc7\u7cfb\u7edf\u75ab\u82d7\u5b66\u548c\u751f\u7269\u6807\u5fd7\u7269\u53d1\u73b0\u7684\u6700\u65b0\u8fdb\u5c55\uff0c\u8bc4\u8ff0\u52a8\u7269\u6a21\u578b\u548c\u4eba\u7c7b\u4e2d\u4e0e\u8fd9\u4e9b\u4f50\u5242\u75ab\u82d7\u6027\u80fd\u76f8\u5173\u7684\u673a\u5236\u3002\u6211\u4eec\u9664\u4e86\u63d0\u51fa\u4e86\u4e00\u4e9b\u5173\u4e8e\u5c1a\u5b58\u77e5\u8bc6\u5dee\u8ddd\u7684\u89c2\u70b9\uff0c\u4e5f\u63d0\u51fa\u4e86\u53ef\u4ee5\u52a0\u901f\u5f00\u53d1\u65b0\u75ab\u82d7\u673a\u4f1a\u7684\u89c2\u70b9\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/span><\/h1>\n
\n
\n
1. \u7b80\u4ecb<\/section>\n<\/section>\n<\/section>\n

<\/span><\/h1>\n

\u867d\u7136\u4f50\u5242\u5df2\u88ab\u7528\u4e8e\u5927\u591a\u6570\u706d\u6d3b\u75ab\u82d7\u7684\u5236\u5907\u4e2d\uff0c\u4f46\u5176\u672c\u8eab\u7684\u53d1\u5c55\u5374\u975e\u5e38\u7f13\u6162\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u4ecd\u5c11\u6709\u4f50\u5242\u88ab\u6279\u51c6\u7528\u4e8e\u4eba\u7c7b\u3002\u81ea\u4e0a\u4e16\u7eaa20\u5e74\u4ee3\u94dd\u76d0\uff08\u660e\u77fe\uff09\u5f00\u59cb\u7528\u4e8e\u5236\u5907\u7834\u4f24\u98ce\u548c\u767d\u5589\u7c7b\u6bd2\u7d20\u540e\uff0c\u6211\u4eec\u4e0d\u5f97\u4e0d\u7b49\u523090\u5e74\u4ee3\u624d\u770b\u5230\u7b2c\u4e00\u6279\u542b\u6709\u201c\u65b0\u201d\u4f50\u5242\uff08\u5373\u6c34\u5305\u6cb9MF59\u4f5c\u4e3a\u8001\u5e74\u4eba\u6d41\u611f\u75ab\u82d7\u7684\u4e00\u90e8\u5206\uff09\u7684\u75ab\u82d7\u88ab\u6279\u51c6\u4e0a\u5e02\u3002\u8fdb\u516521\u4e16\u7eaa\u540e\uff0c\u53c8\u76f8\u7ee7\u6709\u4f50\u5242\u75ab\u82d7\u88ab\u6279\u51c6\u4e0a\u5e02\uff1a\u9884\u9632\u79bd\u6d41\u611f\u75c5\u6bd2\uff08\u542bAS03\uff09\u3001\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u548c\u4eba\u4e73\u5934\u7624\u75c5\u6bd2\uff08HPV\uff09\uff08\u5747\u542b\u6709AS04\uff09\u662f\u5e26\u72b6\u75b1\u75b9\u75c5\u6bd2\uff08\u542bAS01\uff09\u548cHBV\uff08\u542bCpG\uff09\u7684\u75ab\u82d7\u8fde\u7eed\u83b7\u6279\uff08\u88681\uff09\u3002<\/span> <\/span><\/p>\n

\u88681 \u672c\u7efc\u8ff0\u4e2d\u8ba8\u8bba\u7684\u4f50\u5242\u7684\u6210\u5206\u3002<\/span><\/p>\n\n\n\n\n\n\n\n\n
\n

\u4f50\u5242<\/strong><\/span><\/p>\n<\/td>\n

\n

\u6210\u5206<\/strong><\/span><\/p>\n<\/td>\n

\n

\u4f7f\u7528\u8be5\u4f50\u5242\u7684\u75ab\u82d7<\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

MF59<\/span><\/p>\n<\/td>\n

\n

\u89d2\u9ca8\u70ef\uff1b\u805a\u5c71\u68a8\u9187\u916f80\uff1b\u8131\u6c34\u5c71\u68a8\u7cd6\u9187\u4e09\u6cb9\u9178\u916f<\/span><\/p>\n<\/td>\n

\n

\u5b63\u8282\u6027\u6d41\u611f\uff1b\u5927\u6d41\u884c\u6027\u6d41\u611f\uff1b\u79bd\u6d41\u611f<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

AS03<\/span><\/p>\n<\/td>\n

\n

\u89d2\u9ca8\u70ef\uff1b\u03b1-\u751f\u80b2\u915a\uff1b\u805a\u5c71\u68a8\u9187\u916f80<\/span><\/p>\n<\/td>\n

\n

\u5927\u6d41\u884c\u6027\u6d41\u611f\uff1b\u79bd\u6d41\u611f<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

AF03<\/span><\/p>\n<\/td>\n

\n

\u89d2\u9ca8\u70ef\uff1b\u805a\u6c27\u4e59\u70ef\u5341\u516d\u5341\u516b\u70f7\u57fa\u919a\uff1b\u7518\u9732\u9187\uff1b\u8131\u6c34\u5c71\u68a8\u7cd6\u9187\u5355\u6cb9\u9178\u916f<\/span><\/p>\n<\/td>\n

\n

\u5927\u6d41\u884c\u6027\u6d41\u611f<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

AS01<\/span><\/p>\n<\/td>\n

\n

MPLb<\/span><\/sup>\uff1bQS-21c<\/span><\/sup>\uff1b\u8102\u8d28\u4f53<\/span><\/p>\n<\/td>\n

\n

\u5e26\u72b6\u75b1\u75b9<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

AS04<\/span><\/p>\n<\/td>\n

\n

MPL\uff1b\u6c22\u6c27\u5316\u94dd<\/span><\/p>\n<\/td>\n

\n

\u4e59\u809d\uff1bHPV<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

a<\/span><\/sup>\u6709\u5173\u53c2\u8003\u6587\u732e\uff0c\u8bf7\u53c2\u9605\u6587\u672c<\/span><\/p>\n

b<\/span><\/sup>3-O-\u8131\u9170\u57fa-4\u2032-\u5355\u78f7\u9170\u8102\u8d28A<\/span><\/p>\n

c \u7682\u6811\uff08Quillaja saponaria<\/em> Molina\uff09\uff0c\u7ec4\u520621<\/span><\/p>\n


<\/p>\n

\u65b0\u4f50\u5242\u75ab\u82d7\u7684\u8fd9\u79cd\u76f8\u5bf9\u7f13\u6162\u7684\u5f00\u53d1\u5468\u671f\u662f\u7531\u51e0\u4e2a\u56e0\u7d20\u5bfc\u81f4\u7684\u3002\u5bf9\u4f50\u5242\u7684\u9700\u6c42\u4e3b\u8981\u539f\u5b50\u4f7f\u7528\u66f4\u7eaf\u7ec4\u5206\uff08\u4f8b\u5982\u7eaf\u5316\u7684\u91cd\u7ec4\u6297\u539f\uff09\u7684\u66f4\u5b89\u5168\u7684\u75ab\u82d7\u3002\u4e0e\u51cf\u6bd2\u6d3b\u6027\u6216\u706d\u6d3b\u7684\u5168\u7ec6\u80de\u75ab\u82d7\u8fd9\u4e9b\u62e5\u6709\u7531\u5404\u79cd\u514d\u75ab\u523a\u6fc0\u6210\u5206\uff08\u5982\u7ec6\u80de\u58c1\u7684\u7ec6\u83cc\u6210\u5206\u3001\u9057\u4f20\u7269\u8d28\uff09\u4ecb\u5bfc\u7684\u5185\u5728\u4f50\u5242\u6d3b\u6027\u7684\u75ab\u82d7\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u66f4\u5b89\u5168\u7684\u75ab\u82d7\u8868\u73b0\u51fa\u8f83\u4f4e\u7684\u514d\u75ab\u539f\u6027\u3002\u4e3a\u4e86\u8bc1\u660e\u4f50\u5242\u5728\u666e\u901a\u6297\u539f\u4e0a\u7684\u9644\u52a0\u4ef7\u503c\uff0c\u9700\u8981\u4ea7\u751f\u66f4\u591a\u7684\u8bc1\u636e\u6765\u9a8c\u8bc1\u4f50\u5242\u7684\u4f7f\u7528\uff0c\u4ece\u800c\u589e\u52a0\u4e86\u75ab\u82d7\u7814\u5236\u7684\u65f6\u95f4\u3002\u7279\u522b\u662f\uff0c\u4eba\u4eec\u5f00\u53d1\u4e86\u4f50\u5242\u75ab\u82d7\u4ee5\u8fbe\u5230\u4e00\u4e2a\u7528\u66f4\u7ecf\u5178\u7684\u65b9\u6cd5\u6216\u4ee5\u94dd\u4f50\u5242\u4e3a\u57fa\u7840\u7684\u75ab\u82d7\u65e0\u6cd5\u8fbe\u5230\u7684\u514d\u75ab\u53cd\u5e94\u7684\u6c34\u5e73\u548c\u8d28\u91cf\uff0c\u4f8b\u5982\u759f\u75be\u6216HIV\u75ab\u82d7\u7684\u5f00\u53d1\u3002\u7531\u4e8e\u7edd\u5927\u591a\u6570\u73b0\u6709\u75ab\u82d7\u90fd\u9488\u5bf9\u5065\u5eb7\u53d7\u8bd5\u8005\uff0c\u56e0\u6b64\u5bf9\u5176\u5b89\u5168\u6027\u7684\u8bc4\u4f30\u81f3\u5173\u91cd\u8981\u3002\u8fd9\u610f\u5473\u7740\u5bf9\u4e8e\u542b\u6709\u65b0\u4f50\u5242\uff08\u5373\u9664\u94dd\u76d0\u4e4b\u5916\u7684\u4f50\u5242\uff09\u7684\u75ab\u82d7\uff0c\u6709\u5fc5\u8981\u5728\u4f50\u5242\u5316\u75ab\u82d7\u83b7\u5f97\u76d1\u7ba1\u673a\u6784\u6279\u51c6\u4e4b\u524d\uff0c\u5efa\u7acb\u4e00\u4e2a\u8db3\u591f\u5927\u7684\u6db5\u76d6\u4e0d\u540c\u5e74\u9f84\u4e2a\u4f53\u7684\u5b89\u5168\u6027\u6570\u636e\u5e93\u3002\u8fd9\u9700\u8981\u8fdb\u884c\u5927\u89c4\u6a21\u7684\u6709\u9002\u5f53\u6837\u672c\u91cf\u7684\u4e34\u5e8aIII\u671f\u7814\u7a76\uff0c\u5e76\u4e14\u9700\u8981\u6570\u5e74\u7684\u65f6\u95f4\u3002<\/span><\/p>\n

\u5c3d\u7ba1\u572820\u4e16\u7eaa90\u5e74\u4ee3\u53d1\u73b0\u4e86Toll\u6837\u53d7\u4f53\uff08TLR\uff09\uff0c\u5e76\u4e14\u5728\u540e\u6765\u76f8\u7ee7\u53d1\u73b0\u66f4\u591a\u7684\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7684\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\uff0c\u4f46\u5bf9\u4e8e\u90a3\u4e9b\u4e0d\u901a\u8fc7\u8fd9\u4e9b\u53d7\u4f53\u8d77\u4f5c\u7528\u7684\u4f50\u5242\uff0c\u5982\u94dd\u76d0\u548c\u4e73\u5242\uff0c\u4ecd\u5b58\u6709\u4e00\u4e9b\u8ba4\u77e5\u5dee\u8ddd\u3002\u66f4\u65e9\u5730\u4e86\u89e3\u4f50\u5242\u7684\u4f5c\u7528\u673a\u5236\u53ef\u80fd\u6709\u52a9\u4e8e\u52a0\u901f\u4f50\u5242\u7684\u53d1\u5c55\uff0c\u56e0\u4e3a\u53d1\u73b0\u5b89\u5168\u7684\u751f\u7269\u6807\u5fd7\u7269\u548c\u75be\u75c5\u4fdd\u62a4\u7684\u76f8\u5173\u6027\u5c06\u6709\u52a9\u4e8e\u8bc4\u4f30\u5f00\u53d1\u4e2d\u7684\u4f50\u5242\u75ab\u82d7\u7684\u6548\u529b\u548c\u5b89\u5168\u6027\u3002\u65b0\u6280\u672f\uff0c\u5982\u7cfb\u7edf\u75ab\u82d7\u5b66\uff0c\u88ab\u66f4\u65e9\u7684\u5e94\u7528\u4e8e\u7528\u65b0\u578b\u4f50\u5242\u914d\u5236\u800c\u6210\u7684\u75ab\u82d7\u7684\u68c0\u6d4b\u4e2d\uff0c\u5e0c\u671b\u80fd\u52a0\u901f\u5b83\u4eec\u7684\u5f00\u53d1\uff0c\u5e76\u6700\u7ec8\u5c06\u5176\u5f15\u5165\u4e34\u5e8a\u5b9e\u8df5\u3002<\/span><\/p>\n

\u5728\u672c\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u5c06\u8ba8\u8bba\u5f53\u524d\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u4f7f\u7528\u7684\u4f50\u5242\u7684\u4f5c\u7528\u673a\u5236\u548c\u514d\u75ab\u751f\u7269\u5b66\u4f5c\u7528\u3002\u8be5\u4e13\u9898\u7814\u7a76\u4e2d\u7684\u5176\u4ed6\u7efc\u8ff0\u5c06\u6db5\u76d6\u5176\u4ed6\u4ecd\u5904\u4e8e\u4e0d\u540c\u5f00\u53d1\u9636\u6bb5\u7684\u75ab\u82d7\u4f50\u5242\u3002<\/span><\/p>\n

<\/span><\/h1>\n
\n
\n
2. \u57fa\u4e8e\u94dd\u76d0\u7684\u4f50\u5242<\/section>\n<\/section>\n<\/section>\n

<\/span><\/h1>\n

\u5c3d\u7ba1\u94dd\u76d0\u5728\u75ab\u82d7\u4e2d\u5df2\u88ab\u666e\u904d\u4f7f\u7528\uff0c\u4f46\u6211\u4eec\u4eca\u5929\u6240\u77e5\u9053\u7684\u5927\u90e8\u5206\u4fe1\u606f\u90fd\u6765\u81ea\u4e8e\u89c2\u5bdf\uff0c\u800c\u4e0d\u662f\u4e13\u95e8\u9488\u5bf9\u4eba\u7c7b\u7684\u673a\u7406\u7814\u7a76\u3002<\/span><\/p>\n

\u4eba\u4eec\u666e\u904d\u8ba4\u4e3a\uff0c\u5728\u5c0f\u9f20\u4e2d\uff0c\u94dd\u76d0\u662fTh2\u578b\u514d\u75ab\u53cd\u5e94\u7684\u6709\u6548\u8bf1\u5bfc\u5242\u3002\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u8fd9\u79cdTh2\u504f\u5411\u662f\u5426\u4e5f\u5b58\u5728\u4e8e\u4eba\u7c7b\u8eab\u4e0a\u3002\u603b\u7684\u6765\u8bf4\uff0c\u5f53\u5bf9\u4eba\u7c7b\u8fdb\u884c\u8bc4\u4f30\u65f6\uff0c\u94dd\u76d0\u5e76\u4e0d\u662fT\u7ec6\u80de\u5e94\u7b54\u7684\u6709\u6548\u8bf1\u5bfc\u5242\u3002\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e\u4e0eTLR\u523a\u6fc0\u76f8\u6bd4\uff0c\u5b83\u5bf9\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7f3a\u4e4f\u6709\u6548\u523a\u6fc0\u3002\u5728\u52a8\u7269\u8eab\u4e0a\uff0c\u94dd\u76d0\u88ab\u8bc1\u660e\u53ef\u4ee5\u523a\u6fc0\u4ea7\u751f\u4e00\u5b9a\u7a0b\u5ea6\u7684\u708e\u75c7\uff0c\u5c3d\u7ba1\u8fd9\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u53d6\u51b3\u4e8e\u6ce8\u5c04\u90e8\u4f4d\u548c\u94dd\u76d0\u7c7b\u578b\u3002\u73b0\u5728\u5f88\u6e05\u695a\u7684\u662f\uff0c\u94dd\u4f50\u5242\u7684\u4f50\u5242\u6d3b\u6027\u4e0d\u80fd\u7b80\u5355\u5730\u7528\u201c\u50a8\u5e93\u6548\u5e94\u201d\u6765\u89e3\u91ca\uff0c\u6b63\u5982\u4f7f\u7528\u653e\u5c04\u6027\u6807\u8bb0\u6297\u539f\u63a5\u79cd\u540e\u5207\u9664\u63a5\u79cd\u4f4d\u70b9\u76ae\u80a4\u7684\u7814\u7a76\u7ed3\u679c\u6240\u793a\u3002<\/span><\/p>\n

\u94dd\u76d0\u5f15\u8d77\u5148\u5929\u6027\u523a\u6fc0\u7684\u4fe1\u53f7\u4ecd\u7136\u662f\u4e00\u4e2a\u4e89\u8bba\u7684\u95ee\u9898\u3002\u5b83\u4eec\u7684\u4f50\u5242\u6d3b\u6027\u4e0d\u662f\u901a\u8fc7TLR-\u4f9d\u8d56\u6027\u4fe1\u53f7\u53d1\u751f\u7684\uff0c\u56e0\u4e3a\u5f53\u7ed9\u4e88\u94dd\u4f50\u5242\u6297\u539f\u7ed9MYD88\u548cTIF\u6572\u9664\u5c0f\u9f20\u65f6\uff0c\u5bf9T\u7ec6\u80de\u4f9d\u8d56\u6027\u6297\u539f\u7684\u6297\u4f53\u5e94\u7b54\u4fdd\u6301\u4e0d\u53d8\u3002\u94dd\u4f50\u5242\u7684\u786e\u5207\u5206\u5b50\u9776\u70b9\u4e00\u76f4\u96be\u4ee5\u786e\u5b9a\uff0c\u76f4\u5230\u6709\u4e0d\u540c\u7684\u7814\u7a76\u5c0f\u7ec4\u62a5\u9053\u79f0\uff0c\u5728\u5c0f\u9f20\u4e2d\u8be5\u9776\u70b9\u53ef\u80fd\u662fNod\u6837\u53d7\u4f53\u86cb\u767d3\uff08NLRP3\uff09\u3002\u7684\u786e\uff0cNLRP3-\u6216Caspase 1-\u7f3a\u9677\u5c0f\u9f20\u5bf9\u94dd\u4f50\u5242\u6297\u539f\uff08\u4f8b\u5982Dt\/TT\u3001OVA\u6216HSA\uff09\u7684\u6297\u4f53\u53cd\u5e94\u53d7\u635f\u3002\u7136\u800c\uff0c\u5176\u4ed6\u4eba\u65e0\u6cd5\u518d\u73b0\u8fd9\u79cd\u6548\u5e94\u3002\u6700\u8fd1\u6709\u4eba\u5047\u8bbe\uff0c\u94dd\u6676\u4f53\u7684\u541e\u566c\u4f5c\u7528\u53ef\u4ee5\u5728\u6fc0\u6d3bNLRP3\u7684\u57fa\u7840\u4e0a\uff0c\u901a\u8fc7\u541e\u566c\u6eb6\u9176\u4f53\u7684\u6eb6\u80c0\u548c\u7834\u88c2\uff0c\u968f\u540e\u91ca\u653e\u7ec4\u7ec7\u86cb\u767d\u9176B\u5230\u7684\u7ec6\u80de\u8d28\u4e2d\uff0c\u53c2\u4e0eCaspase 1\u7684\u6fc0\u6d3b\u548cIL-1\u03b2\u7684\u91ca\u653e\u3002\u867d\u7136\u8fd9\u4e9b\u5047\u8bbe\u5f88\u5438\u5f15\u4eba\uff0c\u4f46\u9700\u8981\u5728\u4eba\u7c7b\u8eab\u4e0a\u9a8c\u8bc1\u3002\u5bf9\u5065\u5eb7\u4eba\u7c7b\u5fd7\u613f\u8005\u9996\u5148\u7528canakinumab\uff08\u4e00\u79cd\u9488\u5bf9IL-1\u03b2\u7684\u4eba\u5355\u514b\u9686\u6297\u4f53mAb\uff09\u8fdb\u884c\u6cbb\u7597\uff0c\u7136\u540e\u7528\u6c22\u6c27\u5316\u94dd\u4f50\u5242-\u8111\u819c\u708e\u7403\u83cc\u7ed3\u5408\u75ab\u82d7\u8fdb\u884c\u514d\u75ab\uff0c\u89c2\u5bdf\u5230\u7684\u5bf9\u75ab\u82d7\u7684\u6297\u4f53\u53cd\u5e94\u4e0e\u5728\u6ca1\u6709\u63a5\u53d7\u8fc7mAb\u6cbb\u7597\u7684\u5bf9\u7167\u7ec4\u4e2d\u6ca1\u6709\u5dee\u5f02\u3002\u8fd9\u4e00\u7ed3\u679c\u4e0d\u652f\u6301\u201c\u5bf9IL-1\u03b2\u7684\u76f4\u63a5\u4f5c\u7528\u201d\u7684\u5047\u8bbe\u3002\u6211\u4eec\u4ecd\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u6765\u63ed\u793a\u94dd\u76d0\u4f50\u5242\u6d3b\u6027\u7684\u5b9e\u9645\u5206\u5b50\u673a\u5236\u3002\u53e6\u5916\uff0c\u4ecd\u6709\u5f85\u53d1\u73b0\u7684\u5185\u5728\u5e94\u6fc0\u4fe1\u53f7\u53ef\u80fd\u662f\u5728\u5c0f\u9f20\u4e2d\u89c2\u5bdf\u5230\u7684\u6548\u5e94\u7684\u539f\u56e0\u3002<\/span><\/p>\n

\u5c0f\u9f20\u4e2d\u7684\u57fa\u56e0\u8868\u8fbe\u5206\u6790\u663e\u793a\uff0c\u4fc3\u708e\u9014\u5f84\uff08\u5305\u62ecIL-1\u03b2\uff09\u4e5f\u5e38\u89c1\u4e8e\u5176\u4ed6\u4f50\u5242\uff0c\u5982MF59\u548cCpG [19]\u3002\u5728\u8be5\u7814\u7a76\u4e2d\uff0c312\u4e2a\u4e0a\u8c03\u57fa\u56e0\u4e2d\u53ea\u670924\u4e2a\u5bf9\u94dd\u4f50\u5242\u5177\u6709\u7279\u5f02\u6027\u3002\u6b64\u5916\uff0c\u4e0eMF59\u548cCpG\u76f8\u6bd4\uff0c\u4e00\u4e9b\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\uff08\u5305\u62ecIL-1\u03b2\uff09\u7684\u5c40\u90e8\u8868\u8fbe\u88ab\u5ef6\u8fdf\uff0c\u6b63\u5982MHC I\u7c7b\u548cII\u7c7b\u7684\u8868\u8fbe\u4e00\u6837\u3002\u6700\u540e\uff0c\u4e0e\u5176\u4ed6\u4f50\u5242\u76f8\u6bd4\uff0c\u94dd\u76d0\u672a\u80fd\u5728\u5916\u5468\u8840\u4e2d\u8bf1\u5bfc\u53ef\u68c0\u51fa\u7684\u7ec6\u80de\u56e0\u5b50\u3002\u867d\u7136\u80fd\u591f\u4fc3\u8fdb\u6297\u539f\u5448\u9012\u7ec6\u80de\uff08APC\uff09\u7684\u6297\u539f\u6444\u53d6\uff0c\u4f46\u94dd\u76d0\u4e0d\u80fd\u76f4\u63a5\u6fc0\u6d3b\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\uff0c\u8fd9\u8868\u660eAPC\u6fc0\u6d3b\u53ef\u80fd\u662f\u7531\u95f4\u63a5\u4f53\u5185\u5c40\u90e8\u708e\u75c7\u800c\u975e\u94dd\u4f50\u5242\u672c\u8eab\u89e6\u53d1\u7684\u3002\u8fd9\u53ef\u4ee5\u89e3\u91ca\u4e3a\u4ec0\u4e48\u94dd\u76d0\u4e0d\u662f\u7ec6\u80de\u514d\u75ab\u7684\u5f3a\u8bf1\u5bfc\u5242\u3002<\/span><\/p>\n

\u6700\u8fd1\u5bf9\u6052\u6cb3\u7334\u7684\u7814\u7a76\u8bc1\u5b9e\u5e76\u6269\u5c55\u4e86\u5728\u5c0f\u9f20\u4e2d\u7684\u5927\u90e8\u5206\u89c2\u5bdf\u7ed3\u679c\u3002\u7528\u94dd\u4f50\u5242\u7684HIV Env\u75ab\u82d7\u514d\u75ab\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\uff08NHP\uff09\u4f1a\u8bf1\u5bfc\u4e2d\u6027\u7c92\u7ec6\u80de\u3001\u5355\u6838\u7ec6\u80de\u548cDC\u5411\u808c\u8089\u7684\u6d78\u6da6\uff0c\u8fd9\u4e0e\u5176\u4ed6\u4f50\u5242\u5f15\u8d77\u7684\u6d78\u6da6\u76f8\u5f53\uff1b\u7136\u800c\uff0c\u8fd9\u79cd\u6d78\u6da6\u5728\u5f15\u6d41\u6dcb\u5df4\u7ed3\uff08LN\uff09\u4e2d\u4e0d\u592a\u660e\u663e\uff0c\u4e0e\u6240\u63cf\u8ff0\u7684\u94dd\u4f50\u5242\u7684\u751f\u7269\u5206\u5e03\u4e00\u81f4\u3002\u6b64\u5916\uff0c\u94dd\u4f50\u5242\u8fd8\u8bf1\u5bfc\u808c\u8089\u4e2dDC\u548c\u5355\u6838\u7ec6\u80de\u4e0a\u5171\u523a\u6fc0\u5206\u5b50\u7684\u4e0a\u8c03\u6216\u4e0b\u8c03\uff0c\u4ee5\u53ca\u6297\u539f\u9633\u6027\uff08Env+<\/span><\/sup>\uff09\u9aa8\u9ad3\u7ec6\u80de\u548c\u6d46\u7ec6\u80de\u6837\u6811\u7a81\u72b6\u7ec6\u80de\u5411\u5f15\u6d41\u6dcb\u5df4\u7ed3\u7684\u8fc1\u79fb\u3002\u7136\u800c\uff0c\u4e0e\u5176\u4ed6\u4f50\u5242\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u6548\u5e94\u4e0e\u94dd\u4f50\u5242Env\u53ef\u4ee5\u8bf1\u5bfcT\u6ee4\u6ce1\u8f85\u52a9\u6027\uff08Tfh\uff09 CD4+<\/span><\/sup>\u7ec6\u80de\uff08CD3+<\/span><\/sup> CD4+<\/span><\/sup> CXCR5high<\/span><\/sup>\uff0cPD-1high<\/span><\/sup>\uff09\uff0c\u4ee5\u53ca\u5728\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2d\u5f62\u6210\u751f\u53d1\u4e2d\u5fc3\uff08GC\uff09\u7684\u80fd\u529b\u4e0d\u7b26\uff08\u89c1\u4e0b\u6587\uff09\u3002<\/span><\/p>\n

\u5728\u53e6\u4e00\u9879\u4f7f\u7528\u4e0d\u540c\u4f50\u5242\u914d\u5236\u7684HIV Env\u6297\u539f\u514d\u75ab\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u7684\u7814\u7a76\u4e2d\uff0c\u94dd\u4f50\u5242\u5728\u8bf1\u5bfc\u9ad8\u4e14\u6301\u7eed\u6c34\u5e73\u7684\u6297Env\u6297\u4f53\u65b9\u9762\u7684\u8868\u73b0\u4e0d\u5982\u5176\u4ed6\u4f50\u5242\uff0c\u5e76\u4e14ELISPOT\u663e\u793a\uff0c\u5b83\u65e0\u6cd5\u8bf1\u5bfcAg\u7279\u5f02\u6027IFN-\u03b3\u6216\u4ea7\u751fIL-4\u7684\u7ec6\u80de\u3002\u5e94\u8be5\u6ce8\u610f\u7684\u662f\uff0c\u5728\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u4e2d\u89c2\u5bdf\u5230\u7684\u4f50\u5242\u4e4b\u95f4\u7684\u8fd9\u79cd\u5dee\u5f02\u5728\u4f7f\u7528\u5c0f\u9f20\u8fdb\u884c\u7684\u7c7b\u4f3c\u5b9e\u9a8c\u4e2d\u5e76\u4e0d\u660e\u663e\u3002\u4e0e\u5728\u5c0f\u9f20\u4e2d\u62a5\u9053\u7684\u7ed3\u679c\u4e00\u81f4\uff0c\u4e00\u4e9b\u708e\u75c7\u548c\u9ad3\u7cfb\u76f8\u5173\u57fa\u56e0\u6a21\u5757\u88ab\u4e0a\u8c03\uff0c\u800c\u672a\u68c0\u6d4b\u5230\u8840\u6e05\u7ec6\u80de\u56e0\u5b50\u7684\u589e\u52a0\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4e0d\u540c\u7684\u4f50\u5242\u8bf1\u5bfc\u7684\u6297\u4f53\u5728\u8d28\u91cf\u4e0a\u6709\u6240\u4e0d\u540c\uff0c\u5e76\u53ef\u80fd\u5177\u6709\u4e0d\u540c\u7684\u6548\u5e94\u529f\u80fd\u3002\u4f8b\u5982\uff0c\u63a5\u79cd\u94dd\u4f50\u5242Env\u75ab\u82d7\u540e\u4ea7\u751f\u7684\u6297\u4f53\u5728\u4f53\u5916\u53ef\u8bf1\u5bfcNK\u7ec6\u80de\u6700\u5927\u7a0b\u5ea6\u7684\u4ea7\u751fIFN-\u03b3\u3002<\/span><\/p>\n

\u6211\u4eec\u5c1a\u4e0d\u77e5\u5982\u4f55\u5c06\u8fd9\u4e9b\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u89c2\u5bdf\u5230\u7684\u7ed3\u679c\u8f6c\u5316\u5230\u4eba\u7c7b\u8eab\u4e0a\u3002HBV\u75ab\u82d7\u7531\u5438\u9644\u5728\u6c22\u6c27\u5316\u94dd\u4e0a\u7684\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u7ec4\u6210\u3002\u4e0e\u5176\u4ed6\u4f50\u5242\u76f8\u6bd4\uff0c\u8be5\u75ab\u82d7\u5728\u5bf9HBsAg\u4e0d\u654f\u611f\u7684\u5e74\u8f7b\u4eba\u4e2d\u5f15\u53d1\u4e86\u975e\u5e38\u5fae\u5f31\u7684\u5148\u5929\u53cd\u5e94\uff08\u901a\u8fc7\u8840\u7ec6\u80de\u56e0\u5b50\u6216\u9009\u5b9a\u7684\u57fa\u56e0\u8868\u8fbe\u8fdb\u884c\u8bc4\u4f30\uff09\uff0c\u8fd9\u4e0e\u8f83\u4f4e\u7684HBsAg\u6297\u4f53\u548cT\u7ec6\u80de\u53cd\u5e94\u6709\u5173\u3002\u5176\u4ed6\u94dd\u4f50\u5242\u75ab\u82d7\u4e5f\u6709\u7c7b\u4f3c\u7684\u53d1\u73b0\uff08GDG\uff0c\u4e2a\u4eba\u901a\u8baf\uff09\u3002\u8840\u6db2\u4e2d\u4e0d\u5b58\u5728\u663e\u8457\u7684\u5148\u5929\u53cd\u5e94\u5e76\u4e0d\u4e00\u5b9a\u610f\u5473\u7740\u94dd\u76d0\u4e0d\u4f1a\u5728\u6ce8\u5c04\u90e8\u4f4d\u5f15\u53d1\u708e\u75c7\u4fe1\u53f7\uff0c\u5b83\u81f3\u5c11\u8868\u660e\uff0c\u5bf9\u52a8\u7269\u6570\u636e\u7684\u89e3\u91ca\u5e94\u8be5\u8c28\u614e\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u4e0e\u52a8\u7269\u76f8\u6bd4\uff0c\u975e\u4f50\u5242\u7684\u4e00\u4e9b\u5176\u4ed6\u56e0\u7d20\u53ef\u80fd\u4e5f\u4f1a\u5bfc\u81f4\u5728\u4eba\u7c7b\u4e2d\u5dee\u5f02\u3002\u4f8b\u5982\uff0c\u4e00\u9879\u9488\u5bf9\u4eba\u7c7b\u7684\u7814\u7a76\u8868\u660e\uff0cHBV\u75ab\u82d7\u63a5\u79cd\u53ef\u4e0a\u8c03\u4e0d\u540c\u5e74\u9f84\u6bb5\u53d7\u8bd5\u8005\u7684\u4e0d\u540c\u57fa\u56e0\u6a21\u5757\uff1a\u5728\u5e74\u8f7b\u53d7\u8bd5\u8005\u4e2d\u662f\u53c2\u4e0eB\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u7684\u8f6c\u5f55\u6a21\u5757\u3001TCR\u4fe1\u53f7\u4f20\u5bfc\u548c\u6297\u75c5\u6bd2\u53cd\u5e94\uff1b\u800c\u5728\u5e74\u957f\u7684\u53d7\u8bd5\u8005\u4e2d\u5219\u662f\u53c2\u4e0e\u708e\u75c7\u53cd\u5e94\u7684\u8f6c\u5f55\u6a21\u5757\u3001\u7ec6\u80de\u8fc1\u79fb\u53caII\u578b\u5e72\u6270\u7d20\u3002\u8fd9\u9879\u7814\u7a76\u8868\u660e\uff0c\u6211\u4eec\u6240\u89c2\u5bdf\u5230\u7684\u5bf9\u540c\u4e00\u79cd\u75ab\u82d7\u7684\u4e0d\u540c\u53cd\u5e94\u66f4\u5927\u7a0b\u5ea6\u4e0a\u53d7\u63a5\u79cd\u5bf9\u8c61\u7684\u5e74\u9f84\u7684\u5f71\u54cd\uff0c\u800c\u4e0d\u662f\u53d7\u4f50\u5242\u672c\u8eab\u7684\u5f71\u54cd\u3002<\/span><\/p>\n

<\/span><\/h1>\n
\n
\n
3. \u94dd\u76d0\u4f5c\u4e3aTLR\u6fc0\u52a8\u5242\u7684\u8f7d\u4f53<\/section>\n<\/section>\n<\/section>\n

<\/span><\/h1>\n

\u94dd\u76d0\u5df2\u88ab\u7528\u4f5c\u5f00\u53d1\u65b0\u578b\u4f50\u5242\u7684\u5e73\u53f0\uff0c\u4e3b\u8981\u7531\u5438\u9644\u5728\u94dd\u4f50\u5242\u4e0a\u7684\u5404\u79cdTLR\u6fc0\u52a8\u5242\u7ec4\u6210\u3002\u5176\u4e2d\u4e00\u79cd\u88ab\u79f0\u4e3a\u4f50\u5242\u7cfb\u7edfAS04\u7684\uff0c\u5df2\u4f5c\u4e3a\u83b7\u6279\u7684HPV\u548cHBV\u75ab\u82d7\u7684\u4e00\u90e8\u5206\u88ab\u5e94\u7528\u4e8e\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u3002<\/span><\/p>\n

\u5177\u4f53\u5730\u8bf4\uff0cAS04\u662f\u75313-O-\u8131\u9170\u57fa-4\u2032-\u5355\u78f7\u9170\u8102\u8d28A\uff08MPL\uff09\u4e0e\u94dd\u76d0\u914d\u5236\u800c\u6210\uff0c\u524d\u8005\u662f\u4ece\u660e\u5c3c\u82cf\u8fbe\u6c99\u95e8\u6c0f\u83cc\u4e2d\u63d0\u53d6\u7684\u8131\u6bd2\u7684\u8102\u591a\u7cd6\uff08LPS\uff09\u3002\u5728\u5c0f\u9f20\u4e2d\u7684\u7814\u7a76\u8868\u660e\uff0c\u5f53\u5438\u9644\u5728\u94dd\u76d0\u4e0a\u65f6\uff0cMPL\u901a\u8fc7TLR4\u4fdd\u7559\u5176\u5b8c\u6574\u7684\u514d\u75ab\u523a\u6fc0\u6d3b\u6027\u3002AS04\u4f7fTLR4\u6d3b\u5316\uff0c\u8fdb\u800c\u5bfc\u81f4\u5728\u6ce8\u5c04\u90e8\u4f4d\u7684\u808c\u8089\u548c\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2d\u7ec6\u80de\u56e0\u5b50\u7684\u5feb\u901f\uff08\u57283-6\u5c0f\u65f6\u5185\uff09\u4ea7\u751f\u548c\u7ec6\u80de\u52df\u96c6\u3002\u5728\u6ce8\u5c04\u540e\u7b2c\u4e00\u5929\u5185\u89c2\u5bdf\u5230\u6d3b\u5316\u7684\u8d1f\u8f7d\u6297\u539f\u7684\u5355\u6838\u7ec6\u80de\u548c\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u589e\u52a0\uff0c\u8fd9\u4e9b\u8fdb\u800c\u8f6c\u5316\u4e3a\u6297\u539f\u7279\u5f02\u6027T\u548cB\u7ec6\u80de\u7684\u6d3b\u5316\uff0c\u4ee5\u53ca\u5f3a\u4e14\u6301\u4e45\u7684\u6297\u4f53\u548c\u7ec6\u80de\u5e94\u7b54\u7684\u8bf1\u5bfc\u3002\u94dd\u76d0\u4f3c\u4e4e\u4e0d\u4e0eMPL\u8d77\u534f\u540c\u589e\u5f3a\u7684\u4f5c\u7528\uff0c\u4f46MPL\u548cAS04\u7684\u5bf9\u6bd4\u663e\u793a\uff0c\u94dd\u76d0\u7684\u5b58\u5728\u5ef6\u957f\u4e86MPL\u5728\u6ce8\u5c04\u90e8\u4f4d\u8bf1\u5bfc\u7684\u7ec6\u80de\u56e0\u5b50\u53cd\u5e94\u3002\u56e0\u6b64\uff0cAS04\u7684\u514d\u75ab\u523a\u6fc0\u4f5c\u7528\u4e3b\u8981\u662f\u7531\u4e8e\u5148\u5929\u7ec6\u80de\u4e0a\u7684TLR4\uff0c\u56e0\u4e3a\u5728\u4eba\u4f53\u4e2d\u4e0d\u8868\u8fbeTLR4\u7684\u6dcb\u5df4\u7ec6\u80de\u4e0d\u76f4\u63a5\u5bf9AS04\u8d77\u53cd\u5e94\u3002<\/span><\/p>\n

\u4e0e\u77ed\u6682\u6027\u548c\u5c40\u90e8\u708e\u75c7\u53cd\u5e94\u4e00\u81f4\uff0cAS04\u5fc5\u987b\u4e0e\u6297\u539f\u5171\u540c\u63a5\u79cd\u6216\u5728\u6297\u539f\u63a5\u79cd\u540e1\u5929\u5185\u5728\u76f8\u540c\u7684\u6ce8\u5c04\u90e8\u4f4d\u65bd\u7528\u3002\u6700\u8fd1\u4f7f\u7528\u4e0e\u4e0d\u540c\u4f50\u5242\u914d\u5236\u7684HBV\u75ab\u82d7\u7684\u7814\u7a76\u8bc1\u5b9e\uff0c\u5b58\u5728\u4e8eHBV\u75ab\u82d7\u4e2d\u7684AS04\u80fd\u591f\u89e6\u53d1\u4eba\u7c7b\u7684\u5148\u5929\u514d\u75ab\uff0c\u4f46\u5176\u6c34\u5e73\u4f4e\u4e8e\u5176\u4ed6\u66f4\u6709\u6548\u7684\u4f50\u5242\u3002\u4e0e\u7528\u94dd\u76d0\u4f50\u5242\u5316\u7684HBV\u75ab\u82d7\u76f8\u6bd4\uff0c\u5728\u63a5\u79cd\u542b\u6709AS04\u7684HBV\u75ab\u82d7\u540e\uff0c\u8840\u6e05\u4e2d\u7684C-\u53cd\u5e94\u86cb\u767d\uff08CRP\uff09\u548cIL-6\u6709\u5c11\u8bb8\u63d0\u9ad8\u3002\u5c3d\u7ba1\u5982\u6b64\uff0cHBsAg\u7279\u5f02\u6027T\u7ec6\u80de\u548c\u6297\u4f53\u7684\u6c34\u5e73\u9ad8\u4e8e\u7528\u94dd\u76d0\u4f50\u5242\u5316\u7684HBV\u75ab\u82d7\u8bf1\u5bfc\u7684\u6c34\u5e73\u3002<\/span><\/p>\n

\u4e0e\u7528\u94dd\u76d0\u4f50\u5242\u7684\u76f8\u540c\u75ab\u82d7\u76f8\u6bd4\uff0c\u7528AS04\u4f50\u5242\u7684HBV\u548cHPV\u75ab\u82d7\u5747\u8bf1\u5bfc\u9ad8\u6c34\u5e73\u7684\u6297\u4f53\uff0c\u8bc1\u660e\u4e86TLR4\u6fc0\u52a8\u5242MPL\u5728\u4eba\u4f53\u4e2d\u7684\u9644\u52a0\u503c\u3002\u8fd9\u79cd\u8f83\u9ad8\u7684\u514d\u75ab\u539f\u6027\u8f6c\u5316\u4e3aHPV 16\/18\u75ab\u82d7\u5bf9\u764c\u524d\u5bab\u9888\u75c5\u53d8\u53d1\u5c55\u7684\u9ad8\u800c\u6301\u4e45\u7684\u6548\u529b\u3002\u73b0\u6709\u6570\u636e\u663e\u793a\uff0c\u8be5\u75ab\u82d7\u7684\u6548\u529b\u5728\u521d\u6b21\u514d\u75ab\u76849\u5e74\u540e\u4ecd\u63a5\u8fd1\u751a\u81f3\u8fbe\u5230100\uff05\u3002\u4e00\u4e9b\u6570\u636e\u8868\u660e\uff0c\u8be5\u75ab\u82d7\u751a\u81f3\u5bf9\u4e00\u4e9b\u975e\u75ab\u82d7\u578b\u522b\u7684HPV\u4e5f\u6709\u4fdd\u62a4\u6548\u529b\u3002\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e\u4ea4\u53c9\u4e2d\u548c\u6297\u4f53\u7684\u4ea7\u751f\uff0c\u6216\u901a\u8fc7\u53ef\u80fd\u7531AS04\u89e6\u53d1\u7684\u5176\u4ed6\u7ec6\u80de\u4ecb\u5bfc\u7684\u673a\u5236\u3002\u8fd9\u79cd\u5e7f\u6cdb\u7684\u514d\u75ab\u539f\u6027\u548c\u6548\u529b\u548c\u7528\u6c34\u5305\u6cb9\u4f50\u5242\u914d\u5236\u7684\u6d41\u611f\u75ab\u82d7\u7684\u60c5\u51b5\u7c7b\u4f3c\uff08\u89c1\u4e0b\u6587\uff09\u3002\u6211\u4eec\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\uff0c\u4ee5\u4e86\u89e3AS04\u4f50\u5242HPV\u75ab\u82d7\u8fd9\u4e00\u6709\u76ca\u4f5c\u7528\u80cc\u540e\u7684\u786e\u5207\u673a\u5236\u3002<\/span><\/p>\n

<\/span><\/h1>\n
\n
\n
4. \u57fa\u4e8e\u4e73\u5242\u7684\u4f50\u5242\uff1aMF59\u548cAS03<\/section>\n<\/section>\n<\/section>\n

<\/span><\/h1>\n

\u957f\u671f\u4ee5\u6765\uff0c\u4e73\u5242\u4e00\u76f4\u88ab\u7528\u4f5c\u75ab\u82d7\u4f50\u5242\uff0c\u4f46\u6211\u4eec\u4e0d\u5f97\u4e0d\u7b49\u5230\u4e0a\u4e2a\u4e16\u7eaa\u7684\u6700\u540e\u51e0\u5e74\u624d\u5c06\u5176\u6279\u51c6\u7528\u4e8e\u4eba\u7c7b\u3002\u4e4b\u6240\u4ee5\u53d1\u751f\u8fd9\u79cd\u60c5\u51b5\uff0c\u662f\u56e0\u4e3a\u7b2c\u4e00\u4ee3\u4f50\u5242\u75ab\u82d7\u4e2d\u4f7f\u7528\u7684\u77ff\u7269\u6cb9\u65e0\u6cd5\u88ab\u4ee3\u8c22\uff0c\u53e6\u5916\uff0c\u5c3d\u7ba1\u5b83\u4eec\u662f\u6297\u4f53\u53cd\u5e94\u7684\u5f3a\u6548\u589e\u6548\u5242\uff0c\u4f46\u5374\u5f15\u8d77\u4e86\u4e0d\u88ab\u5438\u6536\u7684\u65e0\u83cc\u8113\u80bf\u3002\u4f7f\u7528\u53ef\u5b8c\u5168\u4ee3\u8c22\u7684\u6cb9\u5f00\u53d1\u7684\u6c34\u5305\u6cb9\u4e73\u5242\uff08\u5982MF59\uff09\u4ee5\u53ca\u57fa\u4e8e\u4e73\u5242\u7684\u4f50\u5242\u7cfb\u7edf\uff08\u5982AS03\uff09\u89e3\u51b3\u4e86\u8fd9\u4e00\u95ee\u9898\uff0c\u5e76\u9996\u5148\u5f00\u53d1\u4e86\u6539\u8fdb\u7684\u5b63\u8282\u6027\u706d\u6d3b\u6d41\u611f\u75ab\u82d7\uff0c\u7136\u540e\u5f00\u53d1\u4e86\u9488\u5bf9\u79bd\u6d41\u611f\u7684\u75ab\u82d7\uff08H5N1\u548c\u540e\u6765\u7684\u5176\u4ed6\u83cc\u682a\uff09\u53ca\u6700\u7ec8\u5bf9\u6297\u5927\u6d41\u884c\u6027\u6d41\u611f\u7684\u75ab\u82d7\uff082009\u5e74\u7684H1N1\uff09\u3002\u8fd9\u4e9b\u75ab\u82d7\u73b0\u5df2\u5728\u6b27\u6d32\u548c\u7f8e\u56fd\u83b7\u5f97\u6279\u51c6\uff08\u4f8b\u5982\u9002\u7528\u4e8e\u8001\u5e74\u4eba\u53ca\u513f\u7ae5\uff08\u4ec5\u9650\u52a0\u62ff\u5927\uff09\u7684MF59\u4f50\u5242\u5b63\u8282\u6027\u706d\u6d3b\u75ab\u82d7\uff1b\u5728\u6b27\u6d32\u83b7\u6279\u7684MF59-\u548cAS03-\u4f50\u5242\u5927\u6d41\u884c\u75ab\u82d7\uff1b\u5728\u7f8e\u56fd\u83b7\u6279\u7684\u7528\u4e8e\u50a8\u5907\u7684MF59-\u548cAS03-\u4f50\u5242\u7684H5N1\u79bd\u6d41\u611f\u75ab\u82d7\uff09\u3002\u5b83\u4eec\u8fd8\u4e0e\u5176\u4ed6\u5404\u79cd\u4e0d\u540c\u6297\u539f\u4e00\u8d77\uff0c\u88ab\u5e7f\u6cdb\u7528\u4e8e\u5404\u7c7b\u4eba\u7fa4\u4e2d\uff0c\u4f8b\u5982\u6210\u4eba\u3001\u8001\u4eba\u3001\u513f\u7ae5\u3001\u751a\u81f3\u65b0\u751f\u513f\u3001\u5b55\u5987\u7b49\u3002\u603b\u4e4b\uff0c\u5df2\u88ab\u5168\u4e16\u754c\u6570\u767e\u4e07\u4eba\u4f7f\u7528\u7684\u4e73\u5242\u4f50\u5242\u75ab\u82d7\u7684\u76ca\u5904\u548c\u5b89\u5168\u6027\u73b0\u5df2\u5f97\u5230\u5f88\u597d\u7684\u8bc1\u5b9e\u3002<\/span><\/p>\n

\u6c34\u5305\u6cb9\u4e73\u5242\uff08MF59\u3001AS03\u3001AF03\uff0c\u89c1\u88681\uff09\u7684\u5e38\u89c1\u6210\u5206\u662f\u89d2\u9ca8\u70ef\uff0c\u5b83\u662f\u4e00\u79cd\u4eba\u4f53\u7ecf\u80c6\u56fa\u9187\u5408\u6210\u9014\u5f84\u5408\u6210\u7684\u53ef\u5b8c\u5168\u4ee3\u8c22\u7684\u8102\u7c7b\u3002\u9664\u4e86\u660e\u786e\u5b9a\u4e49\u7684\u4e73\u5242\u7a33\u5b9a\u5242\u4e4b\u5916\uff0c\u8fd9\u4e9b\u4f50\u5242\u4e4b\u4e00\uff08AS03\uff09\u8fd8\u542b\u6709\u514d\u75ab\u523a\u6fc0\u5242\u03b1-\u751f\u80b2\u915a\uff08\u7ef4\u751f\u7d20E\uff09\uff0c\u56e0\u6b64\u5b83\u88ab\u79f0\u4e3a\u4f50\u5242\u7cfb\u7edf\u3002<\/span><\/p>\n

\u4e0e\u94dd\u76d0\u76f8\u6bd4\uff0c\u6c34\u5305\u6cb9\u4e73\u5242\u662f\u66f4\u5f3a\u7684\u4f50\u5242\uff0c\u5e76\u4e14\u5177\u6709\u4e0d\u540c\u7684\u4f5c\u7528\u673a\u7406\u3002\u4f46\u4e8c\u8005\u6709\u4e24\u4e2a\u5171\u540c\u70b9\uff1a\uff08i\uff09\u5b83\u4eec\u7684\u4f5c\u7528\u65b9\u5f0f\u5e76\u975e\u901a\u8fc7TLR\u7ed3\u5408\uff1b\uff08ii\uff09\u5b83\u4eec\u7684\u5f00\u53d1\uff0c\u5982\u540c\u94dd\u4f50\u5242\u4e00\u6837\uff0c\u662f\u57fa\u4e8e\u7ecf\u9a8c\u53ca\u4e00\u79cd\u76f8\u5f53\u53e4\u8001\u7684\u7528\u4e8e\u5236\u5907\u5316\u5408\u7269\u7684\u6280\u672f\u7684\uff0c\u800c\u5bf9\u5b83\u4eec\u7684\u514d\u75ab\u523a\u6fc0\u7279\u6027\u7684\u673a\u5236\u7f3a\u4e4f\u575a\u5b9e\u7684\u4e86\u89e3\u3002\u56e0\u6b64\uff0c\u548c\u94dd\u76d0\u7c7b\u4f3c\uff0c\u4e0e\u4e73\u5242\u7684\u4f50\u5242\u6d3b\u6027\u76f8\u5173\u7684\u5206\u5b50\u673a\u5236\u4e5f\u5c1a\u4e0d\u660e\u786e\u3002<\/span><\/p>\n

\u5c31\u50cf\u5728\u8bb8\u591a\u6848\u4f8b\u4e2d\u4e00\u6837\uff0c\u6211\u4eec\u5bf9\u4e73\u5242\u4f5c\u7528\u673a\u5236\u7684\u6709\u9650\u4e86\u89e3\u90fd\u662f\u6765\u81ea\u4e8e\u5bf9\u5c0f\u9f20\u7684\u7814\u7a76\uff0c\u800c\u76f4\u5230\u6700\u8fd1\uff0c\u624d\u6709\u6765\u81ea\u4e8e\u5bf9\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u548c\u4eba\u7c7b\u7684\u7814\u7a76\u3002\u5728\u5c0f\u9f20\u4e2d\uff0cMF59\u53ef\u5728\u4e0d\u8bf1\u5bfc\u50a8\u5e93\u6548\u5e94\u7684\u60c5\u51b5\u4e0b\u4fc3\u8fdb\u6ce8\u5c04\u90e8\u4f4d\u7ec6\u80de\u7684\u5c40\u90e8\u6d3b\u5316\u53caDC\u7684\u6297\u539f\u6444\u53d6\uff0c\u4ece\u800c\u5bfc\u81f4\u5355\u6838CD11b\u548cF4\/80+<\/span><\/sup>\u7ec6\u80de\u7684\u52df\u96c6\u3002\u514d\u75ab\u540e2\u5929\uff0c\u53d1\u73b0\u4e73\u5242\u5b58\u5728\u4e8e\u5f15\u6d41\u6dcb\u5df4\u7ed3\u7684\u88ab\u819c\u4e0b\u6dcb\u5df4\u7aa6\u4e2d\u7684CD80+<\/span><\/sup> CD86+<\/span><\/sup> MHC II+\u7c7b\uff0cCD11c+<\/span><\/sup>\uff0cCD11b+<\/span><\/sup>\u7ec6\u80de\u4e2d\u3002\u5c31\u708e\u75c7\u53cd\u5e94\u7684\u7a0b\u5ea6\u800c\u8a00\uff0cMF59\u5728\u4e0a\u8c03\u4e0e\u5148\u5929\u514d\u75ab\u53cd\u5e94\u76f8\u5173\u7684\u57fa\u56e0\uff08\u5982IL-1b<\/em>\u3001caspase-1<\/em>\u3001Ccr2<\/em>\u53ca\u5176\u914d\u4f53\uff08Ccl2<\/em>\u3001Ccl7<\/em>\u548cCcl8<\/em>\uff09\uff09\u65b9\u9762\u6bd4CpG\u548c\u94dd\u76d0\u66f4\u6709\u6548\u3002\u6700\u8fd1\u7684\u6570\u636e\u663e\u793a\uff0cMF59\u800c\u975e\u5982\u6c22\u6c27\u5316\u94dd\u6216\u78f7\u9178\u9499\u7b49\u7684\u5176\u4ed6\u4f50\u5242\uff0c\u53ef\u8bf1\u5bfc\u7ec6\u80de\u5916ATP\u4ece\u808c\u8089\u91ca\u653e\uff0c\u8fd9\u53ef\u80fd\u4f5c\u4e3a\u4e00\u4e2a\u5185\u6e90\u6027\u5371\u9669\u4fe1\u53f7\u3002\u603b\u7684\u6765\u8bf4\u8fd9\u8868\u660e\uff0c\u611f\u77e5\u4e73\u5242\u4e2d\u7684\u8102\u6ef4\u4f1a\u89e6\u53d1\u5185\u6e90\u6027\u5e94\u6fc0\u4fe1\u53f7\u7684\u91ca\u653e\uff0c\u4ece\u800c\u5bfc\u81f4\u5148\u5929\u514d\u75ab\u9014\u5f84\u7684\u6fc0\u6d3b\u3002\u6b64\u5916\uff0c\u4e0e\u5176\u4ed6\u4f50\u5242\u76f8\u6bd4\uff0cMF59\u4fc3\u8fdbCD11b+<\/span><\/sup>\u7ec6\u80de\u5feb\u901f\u6d41\u5165\u808c\u8089\u3002MHC II+<\/span><\/sup>\u7ec6\u80de\u4e5f\u57284\u5929\u5185\u5728\u808c\u8089\u4e2d\u52df\u96c6\uff0c\u8868\u660eCD11b+<\/span><\/sup>\u7ec6\u80de\u5206\u5316\u4e3a\u8868\u8fbe\u9ad8\u6c34\u5e73\u7684MHC II\u7c7b\u7684\u529f\u80fd\u6027\u708e\u6027\u6811\u7a81\u72b6\u7ec6\u80de\u3002\u603b\u4e4b\uff0c\u867d\u7136\u4e0d\u80fd\u5728\u4f53\u5916\u76f4\u63a5\u6fc0\u6d3b\u6811\u7a81\u72b6\u7ec6\u80de\uff0c\u4f46MF59\u53ef\u4ee5\u4ea7\u751f\u4ee5\u591a\u79cd\u7ec6\u80de\u56e0\u5b50\u8868\u8fbe\u4e3a\u7279\u5f81\u7684\u5c40\u90e8\u514d\u75ab\u523a\u6fc0\u73af\u5883\uff0c\u4ece\u800c\u901a\u8fc7\u4e0eTLR\u975e\u4f9d\u8d56\u6027\u673a\u5236\u95f4\u63a5\u6fc0\u6d3b\u6811\u7a81\u72b6\u7ec6\u80de\u3002\u7c7b\u4f3c\u7684\u6548\u679c\u5728AS03\u4e2d\u4e5f\u6709\u62a5\u9053\u3002\u56e0\u6b64\uff0c\u5355\u6838\u7ec6\u80de\u884d\u751f\u7684\u7ec6\u80de\u800c\u975e\u771f\u6b63\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u4f3c\u4e4e\u5728\u4e73\u5242\u7684\u4f5c\u7528\u6a21\u5f0f\u4e2d\u8d77\u4e86\u91cd\u8981\u4f5c\u7528\u3002\u9664\u4e86\u5728\u6ce8\u5c04\u90e8\u4f4d\u52df\u96c6\u548c\u6fc0\u6d3b\u7ec6\u80de\u5916\uff0c\u4e73\u5242\u8fd8\u6709\u5229\u4e8e\u6297\u539f\u5448\u9012\u7ec6\u80de\u6444\u53d6\u6297\u539f\u5e76\u5c06\u5176\u8f6c\u8fd0\u81f3\u5f15\u6d41\u6dcb\u5df4\u7ed3\u3002AS03\u4e2d\u514d\u75ab\u523a\u6fc0\u5242\u03b1-\u751f\u80b2\u915a\u7684\u5b58\u5728\u4e0e\u5355\u6838\u7ec6\u80de\u5bf9\u6297\u539f\u7684\u6444\u53d6\u589e\u52a0\uff0cCCL2\u3001CCL3\u3001IL-6\u3001CSF3\u548cCXCL1\u7684\u8868\u8fbe\u589e\u52a0\uff0c\u4ee5\u53ca\u66f4\u9ad8\u7684\u6297\u4f53\u5e94\u7b54\u76f8\u5173\u3002<\/span><\/p>\n

\u4e0e\u5176\u77ac\u65f6\u548c\u5c40\u90e8\u6548\u5e94\u4e00\u81f4\uff0c\u4e73\u5242\u9700\u8981\u4e0e\u6297\u539f\u5171\u540c\u5b9a\u4f4d\uff0c\u5e76\u4e14\u4ec5\u57281-2\u5929\u7684\u6709\u9650\u65f6\u95f4\u6bb5\u5185\u5bf9\u6297\u539f\u7279\u5f02\u6027\u53cd\u5e94\u4ea7\u751f\u5f71\u54cd\uff0c\u6b63\u5982AS03\u90a3\u6837\u3002\u8fd9\u4e0e\u751f\u7269\u5206\u5e03\u7814\u7a76\u7684\u7ed3\u679c\u4e00\u81f4\uff1aAS03\u7684\u6210\u5206\u88ab\u8fc5\u901f\u5730\u4ece\u6ce8\u5c04\u90e8\u4f4d\u6e05\u9664\u3002\u91cd\u8981\u7684\u662f\uff0c\u5728\u4e73\u5242\u4e2d\u5f62\u6210\u8102\u6ef4\u662f\u4f50\u5242\u6548\u5e94\u6240\u5fc5\u9700\u7684\uff0c\u56e0\u4e3a\u5355\u72ec\u7684\u89d2\u9ca8\u70ef\u5bf9\u5171\u540c\u65bd\u7528\u7684\u6297\u539f\u7684\u514d\u75ab\u539f\u6027\u6ca1\u6709\u5f71\u54cd\u3002\u6700\u540e\uff0c\u4e73\u5242\u5728\u589e\u5f3a\u6297\u4f53\u53cd\u5e94\u4e0a\u4f18\u4e8e\u94dd\u76d0\u7684\u4f18\u52bf\u4e5f\u53ef\u80fd\u4e0e\u5176\u53ef\u4ee5\u4fc3\u8fdb\u6709\u6548Tfh\u53cd\u5e94\u7684\u80fd\u529b\u6709\u5173\u3002\u5b9e\u9645\u4e0a\uff0cMF59\u4fc3\u8fdb\u4e86\u6709\u6548\u7684\u53ef\u63a7\u5236\u751f\u53d1\u4e2d\u5fc3\uff08GC\uff09B\u7ec6\u80de\u53cd\u5e94\u7a0b\u5ea6\u7684Tfh\u53cd\u5e94\uff0c\u8be5\u53cd\u5e94\u57283\u5468\u9f84\u5c0f\u9f20\u4e2d\u5df2\u7ecf\u53ef\u4ee5\u5b8c\u5168\u53d1\u6325\u4f5c\u7528\u3002<\/span><\/p>\n

\u6700\u8fd1\uff0c\u5728\u7528MF59\u914d\u5236\u7684\u91cd\u7ec4HIV Env\u86cb\u767d\u8fdb\u884c\u808c\u5185\u514d\u75ab\u7684\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u4e2d\u8fdb\u884c\u7684\u7814\u7a76\u4e2d\uff0c\u8bc1\u5b9e\u4e86\u8bb8\u591a\u4e0a\u8ff0\u53d1\u73b0\u3002\u4f50\u5242\u5728\u6ce8\u5c04\u90e8\u4f4d\u8bf1\u5bfc\u514d\u75ab\u7ec6\u80de\u7684\u5feb\u901f\u6d78\u6da6\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u3001\u5355\u6838\u7ec6\u80de\u548c\u6811\u7a81\u72b6\u7ec6\u80de\u6444\u53d6Env\uff0c\u5e76\u4e14\u4ec5\u5728\u5f15\u6d41\u6ce8\u5c04\u90e8\u4f4d\u7684\u6dcb\u5df4\u7ed3\u4e2d\u6709\u8fd9\u4e9b\u7ec6\u80de\u7684\u589e\u591a\u3002\u4ece\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2d\u5206\u79bb\u7684\u5355\u6838\u7ec6\u80de\u3001\u6811\u7a81\u72b6\u7ec6\u80de\u548c\u4e00\u5b9a\u7a0b\u5ea6\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u5728\u4f53\u5916\u523a\u6fc0T\u7ec6\u80de\u65b9\u9762\u662f\u6709\u6548\u7684\u3002\u6b64\u5916\uff0c\u4e0e\u5728\u5c0f\u9f20\u4e2d\u89c2\u5bdf\u5230\u7684\u4e00\u6837\uff0cMF59\u4fc3\u8fdbT\u7ec6\u80de\u7684\u6d3b\u5316\uff0c\u8fdb\u800c\u8f6c\u5316\u4e3a\u589e\u591a\u7684Tfh\u7ec6\u80de\u5206\u5316\u548c\u751f\u53d1\u4e2d\u5fc3\uff08GC\uff09\u7684\u5f62\u6210\u3002<\/span><\/p>\n

\u5728\u4eba\u7c7b\u4e2d\uff0c\u4e0e\u65e0\u4f50\u5242\uff08\u65e0\u8bba\u662f\u79bd\u6d41\u611f\u75ab\u82d7\u8fd8\u662f\u5927\u6d41\u884c\u6d41\u611f\uff09\u75ab\u82d7\u76f8\u6bd4\uff0cMF59\u6216AS03\u4f50\u5242\u6d41\u611f\u75ab\u82d7\u4e00\u76f4\u8868\u73b0\u51fa\u66f4\u9ad8\u7684\u514d\u75ab\u539f\u6027\u3002\u6b64\u5916\uff0c\u4e24\u8005\u90fd\u63d0\u9ad8\u4e86\u56e0\u6d41\u611f\u548c\u6d41\u611f\u76f8\u5173\u75be\u75c5\u4f4f\u9662\u6cbb\u7597\u7684\u6548\u679c\uff0cMF59\u548cAS03\u4e5f\u5bf9\u63d0\u9ad8\u5e7c\u513f\u5b63\u8282\u6027\u6216\u5927\u6d41\u884c\u6027\u6d41\u611f\u548cCMV\u9634\u6027\u6bcd\u4eb2\u4e2d\u7684\u5de8\u7ec6\u80de\u75c5\u6bd2\uff08CMV\uff09\u7684\u7597\u6548\u6709\u6240\u8d21\u732e\u3002<\/span><\/p>\n

\u8fd9\u4e9b\u6709\u76ca\u4f5c\u7528\u5728\u4eba\u7c7b\u8eab\u4e0a\u7684\u786e\u5207\u673a\u5236\u4ecd\u672a\u88ab\u5145\u5206\u4e86\u89e3\u3002\u7136\u800c\uff0c\u6b63\u5982\u52a8\u7269\u6a21\u578b\u6240\u8bc1\u660e\u7684\u90a3\u6837\uff0c\u4e73\u5242\u9a71\u52a8\u65e9\u671f\u708e\u75c7\u7684\u80fd\u529b\u4e5f\u5728\u4eba\u7c7b\u8eab\u4e0a\u5f97\u5230\u4e86\u8bc1\u660e\u3002\u5728\u63a5\u79cd\u4f50\u5242\u6216\u975e\u4f50\u5242\u6d41\u611f\u75ab\u82d7\u7684\u513f\u7ae5\u7684\u8f6c\u5f55\u6c34\u5e73\u4e0a\uff0c\u7814\u7a76\u4e86MF59\u5bf9\u5148\u5929\u514d\u75ab\u7684\u5f71\u54cd\u3002MF59\u7684\u5b58\u5728\u5728\u7b2c1\u5929\u8bf1\u5bfc\u4e86I\u578b\u5e72\u6270\u7d20\u8868\u8fbe\u7684\u5feb\u901f\u63d0\u9ad8\uff0c\u8fd9\u4e0e\u52a0\u5f3a\u540e\u6297\u4f53\u5e94\u7b54\u7684\u589e\u5f3a\u5448\u6b63\u76f8\u5173\u3002\u5728\u63a5\u53d7\u65e0\u4f50\u5242\u6d41\u611f\u75ab\u82d7\u7684\u513f\u7ae5\u4e2d\uff0c\u8fd9\u79cd\u53cd\u5e94\u8f83\u5f31\u4e14\u5ef6\u8fdf\uff08\u81f3\u7b2c7\u5929\uff09\u3002\u8fd9\u4e9b\u6570\u636e\u652f\u6301\u8fd9\u6837\u7684\u89c2\u70b9\uff0c\u5373\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u6c34\u5e73\u7684\u8fd9\u4e9b\u65e9\u671f\u4e8b\u4ef6\u662f\u968f\u540e\u901a\u8fc7\u4ea7\u751fTfh\u7ec6\u80de\u548c\u6811\u7a81\u72b6\u7ec6\u80de\u8bf1\u5bfc\u9002\u5e94\u6027\u6297\u539f\u7279\u5f02\u6027\u514d\u75ab\u7684\u5148\u51b3\u6761\u4ef6\u3002\u8fd9\u5c06\u8f6c\u5316\u4e3a\u80fd\u591f\u4ea7\u751f\u9ad8\u4eb2\u548c\u529b\u6297\u539f\u7279\u5f02\u6027\u6297\u4f53\u7684B\u7ec6\u80de\u7684\u6fc0\u6d3b\uff0c\u5e76\u5206\u5316\u6210\u957f\u5bff\u8bb0\u5fc6B\u7ec6\u80de\uff08MBC\uff09\u3002\u56e0\u6b64\uff0c\u5728\u63a5\u79cdMF59\u4f50\u5242\u7684\u6d41\u611f\u75ab\u82d7\u540e7\u5929\uff0c\u4eba\u7c7b\u4e5f\u663e\u793a\u51fa\u6297\u539f\u7279\u5f02\u6027Tfh\u7684\u4ea7\u751f\uff1bTfh\u7ec6\u80de\u7684\u589e\u52a0\u4e5f\u4e0e\u6297\u4f53\u5bf9\u75ab\u82d7\u7684\u53cd\u5e94\u589e\u5f3a\u6709\u5173\u3002<\/span><\/p>\n

\u5728\u7528AS03\u4f50\u5242\u5316\u7684A\/H1N1\u5927\u6d41\u884c\u6027\u6d41\u611f\u75ab\u82d7\u63a5\u79cd\u540e7\u5929\u4f7f\u7528\u6d46\u7ec6\u80de\u7684\u9ad8\u901a\u91cfB\u7ec6\u80de\u53d7\u4f53\u6d4b\u5e8f\uff0c\u53ef\u4ee5\u533a\u5206\u6700\u8fd1\u4ece\u521d\u59cbB\u7ec6\u80de\u6fc0\u6d3b\u7684\u7ec6\u80de\u548c\u7531\u8bb0\u5fc6\u56de\u5fc6\u6fc0\u6d3b\u7684\u7ec6\u80de\u7684\u5e8f\u5217\u3002\u8fd9\u8868\u660e\u4f50\u5242\u7684\u53cc\u91cd\u4f5c\u7528\uff1a\u901a\u8fc7\u589e\u52a0\u521d\u59cbB\u7ec6\u80de\u7684\u6d3b\u5316\u4ee5\u53ca\u6269\u5927\u5df2\u5b58\u5728\u7684BMC\u6c60\u3002\u4e8b\u5b9e\u4e0a\uff0c\u73b0\u6709\u6570\u636e\u652f\u6301\u8fd9\u6837\u7684\u89c2\u70b9\uff0c\u5373\u7528MF59\u4f50\u5242\u5316\u7684\u5b63\u8282\u6027\u3001\u5927\u6d41\u884c\u6027\u6d41\u611f\u6216\u79bd\u6d41\u611f\u75ab\u82d7\u514d\u75ab\u63a5\u79cd\u540e\uff0c\u6297\u539f\u7279\u5f02\u6027IgG BMC\u7684\u542b\u91cf\u8981\u9ad8\u5f97\u591a\uff0c\u5e76\u4e14\u5b83\u53ef\u4ee5\u5728\u521d\u6b21\u63a5\u79cd\u540e\u76846-8\u5e74\u5185\u5728\u52a0\u5f3a\u540e\u8fc5\u901f\u589e\u591a\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u521d\u6b21\u63a5\u79cd\u65f6\u63a5\u53d7\u542b\u6709MF59\u6216\u542b\u6709AS02\uff08\u542b\u6709MPL\u548cQS-21\u7684\u6c34\u5305\u6cb9\u4e73\u5242\uff09\u7684H5N1\u75ab\u82d7\u7684\u6210\u4eba\u4e2d\uff0c\u589e\u5f3a\u540e\u7684\u6269\u589e\u66f4\u4e3a\u5f3a\u70c8\u3002\u6b64\u5916\uff0cMF59\u4e0e\u5b63\u8282\u6027\u6d41\u611f\u75ab\u82d7\u7684\u5171\u540c\u5b58\u5728\u663e\u7740\u589e\u5f3a\u4e86\u53ef\u4ea4\u53c9\u4e2d\u548c\u6f02\u79fb\u7684A\/H3N2\u6d41\u611f\u75c5\u6bd2\u682a\u4ee5\u53ca\u6f02\u79fb\u7684A\/H5N1\u6d41\u611f\u75c5\u6bd2\u7684\u6297\u4f53\u7684\u4ea7\u751f\uff0c\u8fd9\u4e9b\u6297\u4f53\u7684\u4eb2\u548c\u529b\u540c\u65f6\u663e\u7740\u589e\u52a0\u3002\u4e0e\u4f7f\u7528\u5927\u6d41\u884cA\/H1N1\u75ab\u82d7\u514d\u75ab\u7684\u6210\u4eba\u76f8\u6bd4\uff0c\u8fd9\u5728\u5a74\u513f\u548c\u9752\u5c11\u5e74\u4e2d\u66f4\u4e3a\u660e\u663e\uff0c\u5728\u6ce8\u5c04\u4e86\u8f85\u4ee5MF59\u7684A\/H5N1\u75ab\u82d7\u4e5f\u66f4\u52a0\u660e\u663e\u3002\u8fd9\u4e9b\u7814\u7a76\u4e2d\u7684\u4e00\u4e2a\u72ec\u7279\u53d1\u73b0\u662f\uff0c\u4e0e\u4ec5\u542bH5N1\u7684\u4ee5\u53ca\u94dd\u4f50\u5242H5N1\u75ab\u82d7\u76f8\u6bd4\uff0c\u6cb9\u5305\u6c34\u4f50\u5242\u8bf1\u5bfc\u4e86\u4e3b\u8981\u9488\u5bf9\u542b\u6709\u7ed3\u5408\u4f4d\u70b9\u7684HA\u7684\u7403\u72b6\u5934\u90e8\u7684HA1\u533a\u57df\u7684IgG\u6297\u4f53\u3002\u63a5\u79cd\u524d\u6297\u4f53\u548c\u7531\u5355\u72ec\u6297\u539f\u6216\u94dd\u4f50\u5242\u75ab\u82d7\u8bf1\u5bfc\u7684\u6297\u4f53\u5219\u4e3b\u8981\u9488\u5bf9HA\u7684\u830e\u533a\uff08HA2\uff09\u3002AS03\u4f50\u5242\u7684\u79bd\u6d41\u611f\u75ab\u82d7\u4e5f\u7ed9\u51fa\u4e86\u7c7b\u4f3c\u7684\u7ed3\u679c\u3002\u5bf9\u6765\u81ea\u63a5\u79cdMF59\u4f50\u5242\u7684H1N1\u5927\u6d41\u884c\u6027\u6d41\u611f\u75ab\u82d7\u7684\u53d7\u8bd5\u8005\u7684\u5355\u514b\u9686\u6297\u4f53\u7684\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u4e9b\u6297\u4f53\u8bc6\u522b\u51fa\u91ce\u751f\u578b\u75c5\u6bd2\uff1b\u5bf9\u4e8e\u975e\u4f50\u5242\u75ab\u82d7\u800c\u8a00\uff0c\u5176\u8bf1\u5bfc\u7684\u6297\u4f53\u4e3b\u8981\u9488\u5bf9\u9002\u5e94\u9e21\u80da\u7684\u75c5\u6bd2\u682a\u3002\u8fd9\u8868\u660e\u6c34\u5305\u6cb9\u4f50\u5242\u75ab\u82d7\u6bd4\u65e0\u4f50\u5242\u75ab\u82d7\u66f4\u6709\u6548\uff0c\u7b26\u5408\u513f\u7ae5III\u671f\u6548\u529b\u8bd5\u9a8c\u548c\u8001\u5e74\u4eba\u6709\u6548\u6027\u7814\u7a76\u7684\u6570\u636e\u3002<\/span><\/p>\n

\u6240\u6709\u4f50\u5242\u75ab\u82d7\u7684\u5171\u540c\u70b9\u662f\uff0c\u5f53\u4f7f\u7528\u4e73\u5242\u65f6\uff0c\u5728\u75ab\u82d7\u63a5\u79cd\u540e\u89c2\u5bdf\u5230\u77ed\u671f\u7684\u5c40\u90e8\u548c\u5168\u8eab\u75c7\u72b6\uff08\u901a\u5e38\u79f0\u4e3a\u53cd\u5e94\u539f\u6027\uff09\u7684\u589e\u52a0\u3002\u53cd\u5e94\u539f\u6027\u7684\u673a\u5236\u5c1a\u672a\u83b7\u5f97\u8be6\u7ec6\u7684\u7814\u7a76\uff0c\u5e76\u4e14\u76ee\u524d\u8fd8\u6ca1\u6709\u786e\u5b9a\u7684\u5305\u62ec\u4f50\u5242\u75ab\u82d7\u5728\u5185\u7684\u75ab\u82d7\u53cd\u5e94\u539f\u6027\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002\u5728\u5bf9\u7528AS03\u4f50\u5242A\/H1N1\u5927\u6d41\u884c\u6027\u6d41\u611f\u75ab\u82d7\u63a5\u79cd\u7684\u82f1\u56fd\u6210\u4eba\u4e00\u9879\u7814\u7a76\u7684\u62a5\u544a\u663e\u793a\uff0c\u5728\u90a3\u4e9b\u4ea7\u751f\u4e2d\/\u9ad8\u5f3a\u5ea6\u4e0d\u826f\u53cd\u5e94\u7684\u4e2a\u4f53\u4e2d\uff0c\u4e00\u5c0f\u90e8\u5206\u57fa\u56e0\u8868\u8fbe\u6c34\u5e73\u8f83\u9ad8\uff0c\u4f46\u5c1a\u4e0d\u6e05\u695a\u8fd9\u4e9b\u57fa\u56e0\u662f\u5426\u4e0e\u4e34\u5e8a\u75c7\u72b6\u76f4\u63a5\u76f8\u5173\u3002\u6709\u8da3\u7684\u662f\uff0c\u4ea7\u751f\u4e2d\/\u9ad8\u4e0d\u826f\u53cd\u5e94\u7684\u76f8\u540c\u53d7\u8bd5\u8005\u5728\u63a5\u79cd\u75ab\u82d7\u524d\u540e\u8fc7\u8868\u8fbe\u4e86\u8bb8\u591aB\u7ec6\u80de\u57fa\u56e0\uff0c\u8fd9\u4e00\u7279\u5f81CD27–<\/span><\/sup>CD38high<\/span><\/sup>CD24high<\/span><\/sup>\u8fc7\u6e21\u6027B\u7ec6\u80de\u7684\u63a5\u79cd\u524d\u8fc7\u8868\u8fbe\u76f8\u5173\u3002\u5728\u63a5\u79cd\u5176\u4ed6\u6c34\u5305\u6cb9\u4f50\u5242\uff08GDG\uff0c\u672a\u53d1\u8868\uff09\u540e\u5f88\u65e9\u5c31\u51fa\u73b0\u4e86B\u7ec6\u80de\u7279\u5f81\u3002\u56e0\u6b64\uff0c\u9700\u8981\u786e\u5b9a\u8fd9\u4e9b\u7279\u5f81\u662f\u5bf9\u4e8e\u4e00\u79cd\u7279\u5b9a\u4f50\u5242\u8fd8\u662f\u5bf9\u4e8e\u4e00\u4e2a\u7cfb\u5217\u7684\u4f50\u5242\u5177\u6709\u7279\u5f02\u6027\uff0c\u6216\u8005\u53ef\u4ee5\u4ee3\u8868\u4e00\u79cd\u5bf9\u53cd\u5e94\u539f\u6027\u503e\u5411\u7684\u5171\u540c\u7279\u5f81\uff0c\u8fd9\u79cd\u503e\u5411\u5728\u5177\u6709\u7279\u5b9a\u7684\u75ab\u82d7\u63a5\u79cd\u524d\u8868\u578b\u7684\u4e2a\u4f53\u6216\u5177\u6709\u5b9a\u4e49\u7684\u3001\u4ecd\u672a\u786e\u5b9a\u7684\u9057\u4f20\u7279\u5f81\u7684\u4e2a\u4f53\u4e2d\u66f4\u4e3a\u660e\u663e\u3002<\/span><\/p>\n

<\/span><\/h1>\n
\n
\n
5. \u514d\u75ab\u523a\u6fc0\u5242\u7684\u7ec4\u5408\uff1aAS01\u7684\u4f8b\u5b50<\/section>\n<\/section>\n<\/section>\n

<\/span><\/h1>\n

AS01\u662f\u4e2a\u72ec\u7279\u7684\u4f50\u5242\uff0c\u56e0\u4e3a\u5b83\u542b\u6709\u4e24\u4e2a\u5df2\u77e5\u5177\u6709\u4f50\u5242\u7279\u6027\u7684\u72ec\u7acb\u7684\u514d\u75ab\u523a\u6fc0\u5206\u5b50\uff0c\u5373MPL\u548c\u7682\u82f7QS-21\u3002QS-21\u662f\u4ece\u7682\u6811\uff08Quillaja saponaria<\/em> Molina\uff09\u7684\u6811\u76ae\u63d0\u53d6\u7269\u4e2d\u7eaf\u5316\u7684\u4e09\u841c\u7cd6\u82f7\uff08\u7ec4\u520621\uff09\uff0c\u5176\u5728\u52a8\u7269\u7814\u7a76\u4e2d\u5df2\u77e5\u53ef\u4ee5\u589e\u5f3a\u6297\u4f53\u5e94\u7b54\u548c\u4fc3\u8fdb\u7279\u5f02\u6027T\u7ec6\u80de\u5e94\u7b54\u3002MPL\u548cQS-21\u5728\u80c6\u56fa\u9187\u5b58\u5728\u4e0b\u4e00\u8d77\u914d\u5236\u5728\u8102\u8d28\u4f53\u4e2d\uff0c\u4ee5\u6d88\u9664QS-21\u7684\u6eb6\u8840\u6d3b\u6027\u3002\u867d\u7136MPL\u7684\u4f5c\u7528\u65b9\u5f0f\u5df2\u7ecf\u660e\u786e\u5b9a\u4e49\uff0c\u4f46\u76f4\u5230\u6700\u8fd1\u4eba\u4eec\u624d\u63d0\u51fa\u4e86\u4e00\u4e9b\u5173\u4e8eQS-21\u4f50\u5242\u539f\u6027\u7684\u5206\u5b50\u673a\u7406\u3002\u5728\u808c\u8089\u6ce8\u5c04\u540e\uff0cQS-21\u9776\u5411\u5f15\u6d41\u6ce8\u5c04\u90e8\u4f4d\u7684\u6dcb\u5df4\u7ed3\u4e2d\u7684\u5305\u819c\u4e0b\u5de8\u566c\u7ec6\u80de\uff0c\u5e76\u6fc0\u6d3bcaspase-1\u3002\u5c3d\u7ba1\u5728\u4f53\u5916\uff0ccapsase-1\u7684\u6d3b\u5316\u662fNLRP3\u4f9d\u8d56\u6027\u7684\uff0c\u4f46NRLP3\u5728\u4f53\u5185\u4f3c\u4e4e\u4e0d\u53c2\u4e0e\u4f50\u5242\u6d3b\u6027\u3002\u5f53\u914d\u5236\u5728\u8102\u8d28\u4f53\u4e2d\u65f6\uff0cQS-21\u901a\u8fc7\u80c6\u56fa\u9187\u4f9d\u8d56\u6027\u5185\u541e\u4f5c\u7528\u53d1\u51fa\u4fe1\u53f7\uff0c\u968f\u540e\u662f\u6eb6\u9176\u4f53\u53bb\u7a33\u5b9a\u5316\u548cSyk\u6fc0\u9176\u6d3b\u5316\uff0c\u8fd9\u4e0e\u5176\u4ed6\u4f50\u5242\uff08\u4f8b\u5982\u94dd\u4f50\u5242\uff09\u7c7b\u4f3c\u3002\u603b\u7684\u6765\u8bf4\uff0cAS01\u7ec4\u5206\u5bf9\u5148\u5929\u9014\u5f84\u548c\u7ec6\u80de\u7684\u7279\u5f02\u6027\u6fc0\u6d3b\u662f\u81f3\u5173\u91cd\u8981\u7684\uff0c\u56e0\u4e3a\u5df2\u7ecf\u89c2\u5bdf\u5230\u5355\u72ec\u7f3a\u5931TLR4\u3001caspase-1\u6216\u5305\u819c\u4e0b\u5de8\u566c\u7ec6\u80de\u4f1a\u5f71\u54cdAS01\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684\u4f50\u5242\u6548\u5e94\u3002<\/span><\/p>\n

AS01\u6700\u521d\u662f\u4e3a\u4e86\u4fc3\u8fdb\u7ec6\u80de\u9664\u4e86\u6297\u4f53\u4e4b\u5916\u7684\u6301\u7eed\u53cd\u5e94\u800c\u5f00\u53d1\u7684\uff0c\u76ee\u7684\u662f\u4e3a\u4e86\u5f00\u53d1\u9488\u5bf9\u75c5\u539f\u4f53\u7684\u75ab\u82d7\uff0c\u800c\u7ec6\u80de\u514d\u75ab\u88ab\u8ba4\u4e3a\u5728\u8fd9\u79cd\u4fdd\u62a4\u4e2d\u8d77\u5173\u952e\u4f5c\u7528 [9]\u3002AS01\u73b0\u5728\u5df2\u7ecf\u5728\u51e0\u79cd\u5019\u9009\u75ab\u82d7\u4e2d\u8fdb\u884c\u4e86\u8bc4\u4f30\uff0c\u5e76\u663e\u793a\u51fa\uff0c\u65e0\u8bba\u4f7f\u7528\u4f55\u79cd\u6297\u539f\u3001\u5e74\u9f84\u6216\u7279\u5b9a\u7684\u514d\u75ab\u6761\u4ef6\uff0cAS01\u90fd\u80fd\u6301\u7eed\u589e\u52a0\u6297\u4f53\u548cT\u7ec6\u80de\u7684\u53cd\u5e94\u3002\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u79cd\u589e\u5f3a\u7684\u514d\u75ab\u539f\u6027\u8f6c\u5316\u4e3a\u4e34\u5e8a\u7597\u6548\uff0c\u4f7f\u6076\u6027\u759f\u539f\u866b\u759f\u75be\u75ab\u82d7\u548c\u5e26\u72b6\u75b1\u75b9\u75ab\u82d7\u7684\u5f00\u53d1\u6210\u4e3a\u53ef\u80fd\u3002<\/span><\/p>\n

\u4e0e\u5176\u4ed6\u4f50\u5242\u7684\u60c5\u51b5\u4e00\u6837\uff0c\u5173\u4e8eAS01\u7684\u4f5c\u7528\u673a\u5236\u7684\u5927\u90e8\u5206\u77e5\u8bc6\u90fd\u6765\u81ea\u4e8e\u5bf9\u52a8\u7269\u7684\u7814\u7a76\u2014\u2014\u5c0f\u9f20\u548c\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u2014\u2014\u5728\u8fd9\u4e9b\u7814\u7a76\u4e2d\uff0c\u4f50\u5242\u662f\u7528\u4e0d\u540c\u7684\u6297\u539f\u914d\u5236\u800c\u6210\u7684\uff08\u4f8b\u5982\u4e9a\u5355\u4f4d\u5e26\u72b6\u75b1\u75b9\u75ab\u82d7\u4e2d\u542b\u6709\u7684VZV\u6297\u539fgE\u3001\u5375\u6e05\u86cb\u767d\u3001HBsAg\u7b49\uff09\u3002\u6700\u8fd1\uff0c\u4e00\u4e9b\u4e34\u5e8a\u7814\u7a76\u4f7f\u7528\u8be5\u4f50\u5242\uff08\u5168\u5242\u91cf\u7684\u514d\u75ab\u523a\u6fc0\u5242\uff0c\u79f0\u4e3aAS01B<\/span><\/sub>\uff0c\u6216\u534a\u5242\u91cf\uff0c\u79f0\u4e3aAS01E<\/span><\/sub>\uff09\u4e0eHBsAg\u4e00\u8d77\u7ed9\u836f\u5e76\u4e0e\u5176\u4ed6\u4f50\u5242\uff08\u94dd\u4f50\u5242\u3001AS04\u3001AS03\u3001CpG\uff09\u8fdb\u884c\u6bd4\u8f83\uff0c\u53e6\u5916\uff0c\u8fd8\u6709\u5bf9\u4f7f\u7528RTS,S\u63a5\u79cd\u75ab\u82d7\u540e\u7528\u6076\u6027\u759f\u539f\u866b\u653b\u6bd2\u5fd7\u613f\u8005\u7684\u7814\u7a76\uff0c\u8fd9\u4e9b\u7814\u7a76\u90fd\u7ed9\u51fa\u4e86\u4e00\u4e9b\u989d\u5916\u7684\u4fe1\u606f\u3002<\/span><\/p>\n

\u5176\u5b9e\uff0c\u6765\u81ea\u5c0f\u9f20\u7684\u6570\u636e\u663e\u793a\uff0cAS01\u8bf1\u5bfc\u7c7b\u4f3c\u7684\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7684\u5c40\u90e8\u6d3b\u5316\uff0c\u5982\u5148\u524d\u5bf9\u4e73\u5242\u6216\u57fa\u4e8eTLR\u914d\u4f53\u7684\u4f50\u5242\u6240\u8ff0\u7684\u90a3\u6837\u3002\u7136\u800c\uff0cAS01\u53ef\u4ee5\u66f4\u5feb\u5730\u5f15\u6d41\u5230\u6dcb\u5df4\u7ed3\u5e76\u4e14\u66f4\u6709\u6548\u5730\u6fc0\u6d3b\u66f4\u5e7f\u6cdb\u7684APC\u5e93\uff0c\u5305\u62ec\u5e38\u9a7b\u548c\u5355\u6838\u7ec6\u80de\u884d\u751f\u7684\u6811\u7a81\u7ec6\u80de\u3002\u6b64\u5916\uff0c\u4e0e\u94dd\u4f50\u5242\u6216\u4e73\u5242\u76f8\u6bd4\uff0cAS01\u5728\u4e2a\u4f53\u7ec6\u80de\u6c34\u5e73\u4e0a\u4e0d\u589e\u52a0\u6297\u539f\u6444\u53d6\u672c\u8eab\uff0c\u4f46\u5b83\u589e\u52a0\u643a\u5e26\u6297\u539f\u7684\u7ec6\u80de\u7684\u6570\u91cf\u3002<\/span><\/p>\n

\u81f3\u4e8e\u5176\u4ed6\u4f50\u5242\uff0cAS01\u5fc5\u987b\u5728\u540c\u4e00\u5730\u70b9\u62161-2\u5929\u7684\u65f6\u95f4\u7a97\u53e3\u5185\u91ca\u653e\uff0c\u624d\u80fd\u89c2\u5bdf\u5230\u589e\u5f3a\u7684\u6297\u4f53\u548cT\u7ec6\u80de\u53cd\u5e94\u3002\u4f7fAS01\u4e0e\u672c\u7efc\u8ff0\u4e2d\u63cf\u8ff0\u7684\u5176\u4ed6\u4f50\u5242\u4e0d\u540c\u7684\u662fMPL\u548cQS-21\u4e4b\u95f4\u89c2\u5bdf\u5230\u7684\u534f\u540c\u6548\u5e94\uff0c\u8fd9\u662f\u901a\u8fc7\u7ec4\u5408\u4e24\u79cd\u4e0d\u540c\u7684\u514d\u75ab\u523a\u6fc0\u5242\u83b7\u5f97\u7684\u57fa\u672c\u4f18\u52bf\u3002\u4e00\u4e2a\u5f15\u4eba\u6ce8\u76ee\u7684\u7279\u5f81\u662f\uff0cAS01\u80fd\u591f\u8bf1\u5bfc\u65e0\u6cd5\u7531\u4efb\u4f55\u4e00\u79cd\u6210\u5206\u5355\u72ec\u5f15\u53d1\u7684\u65b0\u9014\u5f84\u3002\u8fd9\u4e9b\u51fa\u73b0\u7684\u9014\u5f84\u5176\u4e2d\u4e4b\u4e00\u662fIFN-\u03b3\u76f8\u5173\u7684\u3002\u5728\u4f53\u5185\u963b\u65adIFN-\u03b3\u6d88\u9664\u4e86MPL\u548cQS-21\u7684\u534f\u540c\u4f5c\u7528\uff0c\u5176\u7279\u5f81\u5728\u4e8e\u5bf9\u5171\u540c\u65bd\u7528\u7684\u6297\u539f\uff08\u5373\u8868\u8fbeIL-2\u3001IFN-\u03b3\u548cTNF-\u03b1\uff09\u7279\u5f02\u7684\u591a\u529f\u80fdCD4+<\/span><\/sup> T\u7ec6\u80de\u7684\u589e\u52a0\uff0c\u800c\u5e76\u975e\u4f9d\u8d56\u4e8e\u6240\u4f7f\u7528\u7684\u6297\u539f\u3002\u7528AS01\u4f50\u5242\u75ab\u82d7\u514d\u75ab\u540e\u51e0\u5c0f\u65f6\uff0c\u7531IL-12\u548cIL-18\u548c\u5de8\u566c\u7ec6\u80de\u4ecb\u5bfc\u7684MPL\u548cQS-21\u7684\u534f\u540c\u4f5c\u7528\u5f15\u53d1\u4e86\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2d\u7684\u7ec6\u80de\u5feb\u901f\u4ea7\u751fIFN-\u03b3\uff08\u4e3b\u8981\u662fNK\u7ec6\u80de\uff09\u3002NK\u7ec6\u80de\u65e9\u671f\u4ea7\u751fIFN-\u03b3\u5bf9\u4e8e\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u6700\u4f73\u6d3b\u5316\u548c\u901a\u8fc7AS01\u4f50\u5242\u5316\u75ab\u82d7\u8bf1\u5bfcTh1\u578b\u529f\u80fd\u6027\u514d\u75ab\u662f\u5fc5\u9700\u7684\u3002\u867d\u7136\u662f\u5728\u5c0f\u9f20\u4e2d\u53d1\u73b0\u4e86\u8be5\u673a\u5236\uff0c\u4f46\u5728\u6ce8\u5c04AS01\u7684\u7315\u7334\u7684\u6dcb\u5df4\u7ed3\u4e2d\u4e5f\u89c2\u5bdf\u5230\u4e86\u7c7b\u4f3c\u7684IFN-\u03b3\u4ea7\u751f\u3002\u5728\u63a5\u79cdRTS,S\u759f\u75be\u75ab\u82d7\u7684\u4eba\u4e2d\uff0c\u5728\u7b2c1\u5929\u8840\u6e05IFN-\u03b3\u7684\u589e\u52a0\uff0c\u4ee5\u53ca\u4ea7\u751f\u7ec6\u80de\u56e0\u5b50\u7684\u6297\u539f\u7279\u5f02\u6027CD4+<\/span><\/sup> T\u7ec6\u80de\u9891\u7387\u7684\u589e\u52a0\u4e5f\u5f88\u660e\u663e\u3002<\/span><\/p>\n

\u5728\u4e0a\u8ff0\u7684\u4f7f\u7528HBsAg\u7684\u6bd4\u8f83\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u4f7f\u7528AS01\u4e2d\u914d\u5236\u7684HBsAg\uff0c\u6700\u663e\u8457\u7684\u662f\u5168\u5242\u91cfAS01B<\/span><\/sub>\uff0c\u662f\u6700\u6709\u6548\u7684\u5148\u5929\u53cd\u5e94\u8bf1\u5bfc\u5242\uff0c\u4e3b\u8981\u5728\u4e24\u5242\u540e\u68c0\u6d4b\u5230\u3002\u65e9\u5728\u514d\u75ab\u540e24\u5c0f\u65f6\u5c31\u89c2\u5bdf\u5230CRP\u3001\u6709\u9650\u6570\u91cf\u7684\u7ec6\u80de\u56e0\u5b50\uff08IL-6\u3001IFN-\u03b3\u548cIP-10\uff09\u4ee5\u53ca\u5355\u6838\u7ec6\u80de\u7684\u77ed\u6682\u589e\u52a0\uff0c\u57281-3\u5929\u5185\u6d88\u9000\u81f3\u57fa\u7ebf\u3002\u5728\u7b2c\u4e8c\u5242\u75ab\u82d7\u540e\uff0c\u4e3b\u8981\u89c2\u5bdf\u5230\u7ec6\u80de\u56e0\u5b50\u548c\u4e0e\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u76f8\u5173\u7684\u9009\u5b9a\u57fa\u56e0\u7684\u8868\u8fbe\u589e\u52a0\uff0c\u7279\u522b\u662fIFN-\u03b3\u548cIP-10\u4ee5\u53ca\u76f8\u5e94\u7684IFN\u53ef\u8bf1\u5bfc\u57fa\u56e0\uff08\u4f8b\u5982STAT1<\/em>\u3001IRF1<\/em>\u3001MX1<\/em>\u548cCXCL10<\/em>\uff09\u3002\u6709\u8da3\u7684\u662f\uff0cAS01\u548cAS03\u4e4b\u95f4\u7684\u8fd9\u79cd\u5148\u5929\u7279\u5f81\u662f\u76f8\u4f3c\u7684\u3002\u7136\u800c\uff0cAS01\u4f50\u5242\u662f\u4fc3\u8fdbHBsAg\u7279\u5f02\u6027\u6297\u4f53\u548cCD4+<\/span><\/sup> T\u7ec6\u80de\u7684\u6700\u6709\u6548\u7684\u4f50\u5242\uff0c\u5e76\u4e14\u8fd8\u4e0e\u66f4\u9ad8\u7684\u53cd\u5e94\u539f\u6027\u75c7\u72b6\u62a5\u544a\u76f8\u5173\u3002\u5b9e\u9645\u4e0a\uff0c\u5148\u5929\u7279\u5f81\u7684\u5f3a\u5ea6\u4e00\u65b9\u9762\u4e0e\u6297\u539f\u7279\u5f02\u6027\u53cd\u5e94\u7684\u6c34\u5e73\u76f8\u5173\uff0c\u53e6\u4e00\u65b9\u9762\u4e0e\u53cd\u5e94\u539f\u6027\u75c7\u72b6\u7684\u6c34\u5e73\u76f8\u5173\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cAS03\u7684\u4e00\u9879\u533a\u522b\u5728\u4e8e\uff1a\u4e0e\u4f7f\u7528AS03\u4f50\u5242\u7684HBsAg\u75ab\u82d7\u76f8\u6bd4\uff0c\u4f7f\u7528AS01B<\/span><\/sub>\u6216AS01E<\/span><\/sub>\u4f50\u5242\u7684HBsAg\u75ab\u82d7\u63a5\u79cd\u540e1\u5929\uff0c\u66f4\u591a\u53d7\u8bd5\u8005\u7684STAT1<\/em>\u57fa\u56e0\u6709\u8f7b\u5fae\u4e0a\u8c03\uff0c\u8fd9\u8868\u660e\u4f7f\u7528AS01\u65f6\uff0c\u5728\u6ca1\u6709\u6297\u539f\u7279\u5f02\u6027\u53cd\u5e94\u7684\u60c5\u51b5\u4e0b\uff0c\u5728\u7b2c\u4e00\u6b21\u63a5\u79cd\u65f6INF-\u03b3\u53cd\u5e94\u5c31\u5df2\u5b58\u5728\uff08\u5fd7\u613f\u8005\u5728\u672c\u7814\u7a76\u4e2d\u5bf9HBV\u4e0d\u654f\u611f\uff09\u3002\u4ee4\u4eba\u60ca\u8bb6\u7684\u662f\uff0c\u5c3d\u7ba1\u4f50\u5242\u4e4b\u95f4\u8bf1\u5bfc\u7684\u6297\u539f\u7279\u5f02\u6027CD4+<\/span><\/sup> T\u7ec6\u80de\u7684\u603b\u9891\u7387\u5b58\u5728\u663e\u7740\u5dee\u5f02\uff0c\u4f46\u591a\u529f\u80fdCD4+<\/span><\/sup> T\u7ec6\u80de\uff08\u5373IL-2\u3001IFN-\u03b3\u548cTNF-\u03b1\u9633\u6027\uff09\u7684\u6bd4\u4f8b\u5728\u5404\u79cd\u4f50\u5242\u95f4\u6ca1\u6709\u5dee\u5f02\u3002\u8fd9\u5728\u67d0\u79cd\u7a0b\u5ea6\u4e0a\u4e0e\u76f4\u89c9\u76f8\u53cd\uff0c\u56e0\u4e3a\u56fa\u6709\u4fe1\u53f7\u7684\u5f3a\u5ea6\uff0c\u5c24\u5176\u662fTh1-\u6781\u5316\u7684\u6027\u8d28\uff0c\u5c06\u88ab\u671f\u671b\u5bfc\u81f4\u66f4\u9ad8\u7684\u591a\u529f\u80fd\u6027\u3002<\/span><\/p>\n


<\/p>\n

\u7cfb\u7edf\u751f\u7269\u5b66\u65b9\u6cd5\u4e5f\u5e94\u7528\u4e8e\u7814\u7a76\u4e2d\uff0c\u5176\u4e2dRTS,S-\u63a5\u79cd\u7684\u4eba\u7c7b\u5fd7\u613f\u8005\u53d7\u5230\u759f\u75be\u5bc4\u751f\u866b\u7684\u653b\u51fb\uff0c\u4ee5\u8bd5\u56fe\u9274\u5b9a\u4e0e\u75ab\u82d7\u8d4b\u4e88\u7684\u4fdd\u62a4\u76f8\u5173\u7684\u6f5c\u5728\u6807\u5fd7\u7269\u3002\u63a5\u79cd\u75ab\u82d7\u524d\u7684\u73af\u5b50\u5b62\u5b50\u86cb\u767d\uff08CSP\uff09\u7279\u5f02\u6027\u6297\u4f53\u6ef4\u5ea6\u4e0e\u759f\u75be\u4fdd\u62a4\u6709\u5173\u3002\u6b64\u5916\uff0c\u4fdd\u62a4\u4f5c\u7528\u4e0eB\u7ec6\u80de\u548c\u6d46\u7ec6\u80de\u7684\u5206\u5b50\u7279\u5f81\u6709\u5173\u3002\u6709\u8da3\u7684\u662f\uff0c\u8840\u6db2\u4e2dNK\u7ec6\u80de\u7684\u7279\u5f81\u4e0e\u4fdd\u62a4\u4f5c\u7528\u5448\u8d1f\u76f8\u5173\u3002\u8fd9\u4e9b\u6570\u636e\u4f3c\u4e4e\u4e0e\u5c0f\u9f20\u548c\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u4e2d\u89c2\u5bdf\u5230\u7684\u7ed3\u679c\u2014\u2014NK\u7ec6\u80de\u65e9\u671f\u4ea7\u751fIFN-\u03b3\uff0c\u4ee5\u53ca\u4eba\u7c7b\u65e9\u671fIFN-\u03b3\u4ea7\u751f\u4f5c\u4e3a\u9884\u9632\u759f\u75be\u53d1\u4f5c\u7684\u6f5c\u5728\u9884\u6d4b\u56e0\u5b50\u8fd9\u4e00\u4e8b\u5b9e\u76f8\u77db\u76fe\u3002\u7136\u800c\uff0c\u8840\u6db2\u4e2dNK\u7ec6\u80de\u6570\u91cf\u7684\u51cf\u5c11\u2014\u2014\u8fd9\u53ef\u80fd\u662f\u5728\u75ab\u82d7\u63a5\u79cd\u7684\u90e8\u4f4d\u52df\u96c6\u7684\u2014\u2014\u53ef\u4ee5\u89e3\u91ca\u4eba\u7c7b\u653b\u6bd2\u6a21\u578b\u4e2d\u89c2\u5bdf\u5230\u7684\u9006\u76f8\u5173\u6027\u3002\u5728\u4e00\u9879\u7c7b\u4f3c\u7684\u7814\u7a76\u4e2d\uff0cIFN-\u03b3\u4fe1\u53f7\u901a\u8def\u7684\u8868\u8fbe\u7b49\u4ee3\u8868\u4e86\u9884\u6d4b\u75ab\u82d7\u8d4b\u4e88\u7684\u6297\u6076\u6027\u759f\u539f\u866b\u759f\u75be\u4fdd\u62a4\u7684\u6700\u4f73\u6a21\u578b\u3002<\/span><\/p>\n

\u6211\u4eec\u4ecd\u9700\u4ece\u673a\u7406\u4e0a\u7406\u89e3AS01\u5728\u9884\u9632\u8001\u5e74\u4eba\u5e26\u72b6\u75b1\u75b9\u548c\u75b1\u75b9\u540e\u795e\u7ecf\u75db\u7684\u75ab\u82d7\u63d0\u4f9b\u7684\u9ad8\u7597\u6548\u4e2d\uff08\u751a\u81f3\u5728\u5e74\u9f84> 80\u5c81\u7684\u4eba\u4e2d\u4e5f\u6709\u89c2\u5bdf\u5230\uff09\u7a76\u7adf\u8d77\u4ec0\u4e48\u4f5c\u7528 [75-77]\u3002\u5f88\u660e\u663e\uff0c\u8be5\u75ab\u82d7\u4ee5\u67d0\u79cd\u65b9\u5f0f\u514b\u670d\u4e86\u8870\u9000\u6216\u53d7\u635f\u7684\u514d\u75ab\u7cfb\u7edf\u7684\u8fd9\u4e00\u5c40\u9650\u6027\uff0c\u5e76\u4e14AS01\u5f88\u6709\u53ef\u80fd\u5728\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\u53d1\u6325\u4e86\u91cd\u8981\u4f5c\u7528\u3002\u5c3d\u7ba1\u6062\u590d\u5bf9VZV\u7684\u7ec6\u80de\u514d\u75ab\u4fdd\u62a4\u6c34\u5e73\u662f\u6240\u63d0\u51fa\u7684\u673a\u5236\u4e4b\u4e00\uff0c\u4f46\u53ef\u80fd\u8fd8\u6d89\u53ca\u5230\u5176\u4ed6\u673a\u5236\u3002\u4e86\u89e3\u8fd9\u79cd\u4fdd\u62a4\u673a\u5236\u9700\u8981\u5728\u9002\u5f53\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\u901a\u8fc7\u5e94\u7528\u7cfb\u7edf\u75ab\u82d7\u5b66\u7684\u65b9\u6cd5\u548c\u6574\u5408\u6709\u5173\u5e74\u9f84\u76f8\u5173\u7684\u514d\u75ab\u53cd\u5e94\u6027\u8870\u9000\u7684\u77e5\u8bc6\u6765\u5b8c\u6210\u3002\u7136\u800c\uff0c\u5e94\u8be5\u6ce8\u610f\u4e0e\u5e74\u9f84\u4e0d\u540c\u7684\u56e0\u7d20\uff08\u4f8b\u5982\u73af\u5883\u56e0\u7d20\u3001\u5408\u5e76\u75c7\u3001\u865a\u5f31\u3001\u836f\u7406\u5b66\u6cbb\u7597\u3001\u514d\u75ab\u53f2\uff09\u5bf9\u611f\u67d3\u53ca\u63a5\u79cd\u75ab\u82d7\u7684\u514d\u75ab\u53cd\u5e94\u4ea7\u751f\u51cf\u5f31\u4f5c\u7528\u7684\u53ef\u80fd\u6027\u3002<\/span><\/p>\n

<\/span><\/h1>\n
\n
\n
6. \u7ed3\u8bba<\/section>\n<\/section>\n<\/section>\n

<\/span><\/h1>\n

\u8fc7\u53bb\u4e8c\u5341\u5e74\u6765\uff0c\u5728\u5f00\u53d1\u65b0\u578b\u75ab\u82d7\u4f50\u5242\u65b9\u9762\u53d6\u5f97\u4e86\u5de8\u5927\u8fdb\u5c55\uff0c\u8fd9\u4e9b\u4f50\u5242\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u5b9e\u8df5\uff0c\u5e76\u4e14\u5728\u9884\u9632\u4f20\u67d3\u75c5\u65b9\u9762\u6709\u975e\u5e38\u597d\u7684\u8868\u73b0\uff0c\u4f8b\u5982\u5728\u73b0\u5b9e\u751f\u6d3b\u4e2d\u7684\u6d41\u611f\u53ca\u7531\u4e8eHPV\u800c\u5bfc\u81f4\u548c\u5bab\u9888\u764c\uff0c\u4ee5\u53ca\u6700\u8fd1\u5728\u4e34\u5e8a\u73af\u5883\u4e2d\u7684\u759f\u75be\u548c\u5e26\u72b6\u75b1\u75b9\u3002\u6b64\u5916\uff0c\u65b0\u65b9\u6cd5\u7684\u5e94\u7528\uff0c\u7edf\u79f0\u4e3a\u7cfb\u7edf\u75ab\u82d7\u5b66\uff0c\u5df2\u5f00\u59cb\u63ed\u793a\u6210\u4eba\u3001\u513f\u7ae5\u548c\u8001\u5e74\u4eba\u4e2d\u589e\u5f3a\u4fdd\u62a4\u6027\u514d\u75ab\u53cd\u5e94\u7684\u6f5c\u5728\u673a\u5236\u3002\u8fd9\u4e9b\u77e5\u8bc6\u5bf9\u4e8e\u9884\u6d4b\u4e0e\u4f50\u5242\u75ab\u82d7\u76f8\u5173\u7684\u4efb\u4f55\u6f5c\u5728\u5b89\u5168\u95ee\u9898\uff0c\u4ee5\u53ca\u53ef\u80fd\u66f4\u597d\u5730\u9884\u6d4b\u7597\u6548\u7279\u522b\u91cd\u8981\u3002\u5728\u8fd9\u65b9\u9762\uff0c\u514d\u75ab\u5e94\u7b54\u6027\u4e0e\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u76f8\u5173\u6027\u53d8\u5f97\u81f3\u5173\u91cd\u8981\u3002<\/span><\/p>\n

\u9700\u8981\u8003\u8651\u7684\u4e00\u4e2a\u91cd\u70b9\u662f\uff0c\u5927\u591a\u6570\u5173\u4e8e\u4f50\u5242\uff08\u5305\u62ec\u94dd\u4f50\u5242\uff09\u7684\u673a\u7406\u7814\u7a76\uff0c\u90fd\u662f\u5728\u5c0f\u9f20\u8eab\u4e0a\u8fdb\u884c\u7684\u3002\u5c0f\u9f20\u6a21\u578b\u7684\u9009\u62e9\u662f\u5408\u7406\u7684\uff0c\u56e0\u4e3a\u5bb9\u6613\u63a5\u89e6\u5230\u5176\u6dcb\u5df4\u5668\u5b98\u5e76\u4e14\u53ef\u4ee5\u7cbe\u7ec6\u5730\u89e3\u5256\u514d\u75ab\u5e94\u7b54\u7684\u5404\u4e2a\u65b9\u9762\u3002\u7136\u800c\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\u83b7\u5f97\u7684\u5927\u591a\u6570\u7ed3\u679c\u9700\u8981\u5728\u4eba\u7c7b\u4e2d\u5f97\u5230\u8bc1\u5b9e\u548c\u9a8c\u8bc1\u3002\u73b0\u6709\u7684\u5728\u4eba\u7c7b\u4e2d\u83b7\u5f97\u7684\u6570\u636e\u5f3a\u8c03\u4e86\u8fd9\u6837\u4e00\u4e2a\u4e8b\u5b9e\uff0c\u5373\u5982\u679c\u52a8\u7269\uff08\u5c0f\u9f20\u548c\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\uff09\u4e0e\u4eba\u7c7b\u4e4b\u95f4\u5b58\u5728\u5171\u6027\uff0c\u90a3\u4e48\u4e5f\u6709\u4e00\u4e9b\u4e0d\u5e94\u5ffd\u89c6\u7684\u7279\u6027\u3002\u4f8b\u5982\uff0c\u7528\u6c34\u5305\u6cb9\uff08\u4f8b\u5982MF59\uff09\u4f50\u5242\u5316\u75ab\u82d7\u514d\u75ab\u5c0f\u9f20\u53ef\u8bf1\u5bfc\u5f3aTh2\u578b\u6297\u4f53\u548c\u7ec6\u80de\u5e94\u7b54\uff0c\u8fd9\u5728\u4efb\u4f55\u5e74\u9f84\u6bb5\u7684\u4eba\u7c7b\u4e2d\u5747\u672a\u89c2\u5bdf\u5230\u3002\u800c\u5728\u4eba\u7c7b\u4e2d\uff0cTh0-Th1\u7279\u5f81\u503e\u5411\u4e8e\u5360\u4f18\u52bf\u3002\u53e6\u5916\uff0c\u7531\u8fd9\u4e9b\u4f50\u5242\u8bf1\u5bfc\u7684\u57fa\u56e0\u8f6c\u5f55\u7269\u5728\u5c0f\u9f20\u548c\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u4e2d\u4e5f\u53ef\u80fd\u4e0d\u540c\u3002\u56e0\u6b64\uff0c\u867d\u7136\u6a21\u578b\u5bf9\u89e3\u51b3\u5177\u4f53\u95ee\u9898\u5f88\u6709\u7528\uff0c\u4f46\u8fd9\u4e9b\u95ee\u9898\u5e94\u8be5\u5728\u4eba\u7c7b\u4e2d\u5f97\u5230\u9a8c\u8bc1\u3002\u53e6\u5916\uff0c\u540c\u6837\u91cd\u8981\u7684\u662f\u8981\u627e\u5230\u7814\u7a76\u4eba\u7c7b\u514d\u75ab\u53cd\u5e94\u7684\u65b9\u6cd5\uff0c\u4f7f\u5f97\u6211\u4eec\u4e0d\u4ec5\u53ef\u4ee5\u9488\u5bf9\u8840\u6db2\u8fdb\u884c\u7814\u7a76\uff08\u5982\u8fc4\u4eca\u4e3a\u6b62\u901a\u5e38\u6240\u505a\u7684\u90a3\u6837\uff09\uff0c\u800c\u4e14\u5728\u6700\u5408\u9002\u7684\u65f6\u95f4\u70b9\u5728\u4f8b\u5982\u9aa8\u9ad3\u548c\u5f15\u6d41\u6dcb\u5df4\u7ed3\u7b49\u7684\u6dcb\u5df4\u5668\u5b98\u4e2d\u4e5f\u53ef\u5c55\u5f00\u7814\u7a76\u3002\u8fd9\u4e9b\u95ee\u9898\u5df2\u5f00\u59cb\u5f97\u5230\u89e3\u51b3\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u66f4\u597d\u5730\u4e86\u89e3\u521d\u59cb\u514d\u75ab\u90e8\u4f4d\uff08\u6ce8\u5c04\u90e8\u4f4d\uff09\u548c\u4fdd\u62a4\u4f5c\u7528\u7684\u9884\u671f\u90e8\u4f4d\u7684\u514d\u75ab\u6548\u5e94\u7269\uff0c\u5bf9\u4e8e\u786e\u4fdd\u5bf9\u8840\u6db2\u4e2d\u514d\u75ab\u5e94\u7b54\u53c2\u6570\u7684\u8bc4\u4f30\u53ef\u4ee5\u771f\u5b9e\u53cd\u6620\u514d\u75ab\u53cd\u5e94\u81f3\u5173\u91cd\u8981\u3002<\/span><\/p>\n

\u57fa\u4e8e\u4e0a\u9762\u8ba8\u8bba\u7684\u5185\u5bb9\uff0c\u4ee4\u4eba\u60ca\u8bb6\u7684\u662f\uff0c\u5c3d\u7ba1\u4e34\u5e8a\u4f7f\u7528\u4e2d\u4e0d\u540c\u4f50\u5242\u7684\u7ec4\u6210\u660e\u663e\u4e0d\u540c\uff08\u94dd\u4f50\u5242\u3001\u6dfb\u52a0\u4e0d\u540c\u6210\u5206\u7684\u6c34\u5305\u6cb9\u8102\u8d28\u4f50\u5242\u7b49\uff09\uff0c\u5728\u63a5\u79cd\u75ab\u82d7\u540e\u7684\u6700\u521d\u51e0\u4e2a\u5c0f\u65f6\u5185\u8868\u73b0\u51fa\u5171\u540c\u7684\u708e\u75c7\u7279\u5f81\u3002\u8fd9\u4e9b\u5dee\u5f02\u66f4\u5177\u5b9a\u91cf\u6027\uff0c\u5e76\u4e14\u66f4\u591a\u5730\u4e0e\u89e6\u53d1\u7684\u4e8b\u4ef6\u7684\u52a8\u529b\u5b66\u76f8\u5173\u8054\u3002\u4f8b\u5982\uff0c\u7528AS03\u4f50\u5242\u7684\u79bdH5N1\u88c2\u89e3\u75ab\u82d7\u514d\u75ab\u7684\u53d7\u8bd5\u8005\u5728\u63a5\u79cd\u540e\u7b2c1\u5929\u663e\u793a\u4e0eIFN\u4fe1\u53f7\u4f20\u5bfc\u76f8\u5173\u7684\u57fa\u56e0\u8f6c\u5f55\u7269\uff08STAT1<\/em>\u3001IRF1<\/em>\u3001GP1<\/em>\uff09\uff0c\u5355\u6838\u7ec6\u80de\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u3001\u6811\u7a81\u72b6\u7ec6\u80de\u3001NK\u7ec6\u80de\u548c\u8840\u6e05\u7ec6\u80de\u56e0\u5b50IL-6\u548cIP-10\u7684\u9891\u7387\u589e\u52a0\uff0c\u4e0e\u63a5\u79cdAS01\u4f50\u5242\u7684HBs Ag\u540e\u7684\u53d1\u73b0\u6ca1\u6709\u592a\u5927\u5dee\u522b\u3002\u6b64\u5916\uff0cBurny\u7b49\u4eba\u7684\u7814\u7a76\u4e2d\u4ee5\u53ca\u53e6\u4e00\u9879\u8c03\u67e5MF59\u4f50\u5242\u7684\u5b63\u8282\u6027\u4e09\u4ef7\u75ab\u82d7\u7684\u7814\u7a76\u663e\u793a\uff0c\u5728\u63a5\u79cd\u540e\u4e00\u5929\u89c2\u5bdf\u5230\u76f8\u4f3c\u7684\u4fdd\u6301\u5728\u751f\u7406\u8303\u56f4\u5185\u7684\u8840\u6e05CRP\u7684\u5cf0\u503c\uff0c\u5176\u540e\u6c34\u5e73\u5728\u75ab\u82d7\u63a5\u79cd2-3\u5929\u540e\u8fbe\u5230\u5cf0\u503c\uff08GDG\uff0c\u672a\u53d1\u8868\uff09\u3002\u968f\u7740\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u7684\u8fdb\u884c\uff0c\u5148\u5929\u53cd\u5e94\u4e2d\u66f4\u5fae\u5999\u7684\u5dee\u5f02\u53ef\u80fd\u4f1a\u53d8\u5f97\u660e\u663e\uff0c\u8fd9\u53ef\u80fd\u89e3\u91ca\u4e86\u7531\u4e0d\u540c\u4f50\u5242\u7684\u75ab\u82d7\u5f15\u53d1\u7684\u514d\u75ab\u53cd\u5e94\u7684\u6570\u91cf\u548c\u8d28\u91cf\u7684\u5dee\u5f02\u3002\u8fd9\u4e9b\u5dee\u5f02\u4e5f\u53ef\u80fd\u53d6\u51b3\u4e8e\u75ab\u82d7\u6297\u539f\uff0c\u56e0\u6b64\u8fd9\u79cd\u4f50\u5242\u6bd4\u8f83\u7684\u7ed3\u8bba\u53ef\u80fd\u4e0d\u4e00\u5b9a\u9002\u7528\u4e8e\u6240\u6709\u6297\u539f\u3002<\/span><\/p>\n

\u4f50\u5242\u7684\u53e6\u4e00\u79cd\u5e38\u89c1\u884c\u4e3a\u662f\u5b83\u4eec\u589e\u52a0\u5f15\u6d41\u6dcb\u5df4\u7ed3\u4e2d\u6297\u539f\u8d1f\u8f7d\u7ec6\u80de\u6570\u91cf\u7684\u80fd\u529b\u3002\u7136\u800c\uff0c\u6211\u4eec\u6240\u77e5\u7684\u4f50\u5242\u5bf9APC\u7684\u5f71\u54cd\u4ec5\u4ec5\u6765\u81ea\u4e8e\u5728\u5c0f\u9f20\u4e2d\u8fdb\u884c\u7684\u7814\u7a76\uff0c\u4ee5\u53ca\u6700\u8fd1\u5728\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u4e2d\u7684\u7814\u7a76\u3002\u5728\u4eba\u7c7b\u7cfb\u7edf\u4e2d\u7684\u7684\u4fe1\u606f\u5f88\u5c11\uff08\u5982\u679c\u6709\u7684\u8bdd\uff09\u3002\u8fd9\u663e\u7136\u662f\u4e00\u4e2a\u503c\u5f97\u8be6\u7ec6\u7814\u7a76\u7684\u9886\u57df\uff0c\u5f53\u83b7\u5f97\u6dcb\u5df4\u7ed3\u6750\u6599\u7684\u65b9\u6cd5\u66f4\u5e7f\u6cdb\u5730\u53ef\u7528\u5e76\u9002\u7528\u4e8e\u4e34\u5e8a\u7814\u7a76\u65f6\uff0c\u8fd9\u4e00\u9886\u57df\u5c06\u5f97\u5230\u66f4\u597d\u7684\u7406\u89e3\u3002\u7279\u522b\u662f\uff0c\u4e86\u89e3\u5355\u6838\u7ec6\u80de\u884d\u751f\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u4e0e\u771f\u6b63\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u5728\u4f50\u5242\u4ecb\u5bfc\u7684\u4eba\u7c7b\u7ec6\u80de\u523a\u6fc0\u4e2d\u7684\u76f8\u5bf9\u4f5c\u7528\u662f\u5f88\u91cd\u8981\u7684\u3002<\/span><\/p>\n

\u6dcb\u5df4\u7ed3\u7684\u83b7\u5f97\u4e5f\u5c06\u6709\u52a9\u4e8e\u9a8c\u8bc1\u4e0eTfh\u548c\u751f\u53d1\u4e2d\u5fc3\u5f62\u6210\u76f8\u5173\u7684\u5047\u8bf4\uff0c\u7279\u522b\u662f\u5bf9\u4e8e\u4e73\u5242\u6765\u8bf4\uff0c\u5bf9Tfh\u7684\u4f5c\u7528\u5df2\u7ecf\u5f97\u5230\u8bc1\u660e\u3002\u6211\u4eec\u77e5\u9053\u6c34\u5305\u6cb9\u4f50\u5242MF59\u80fd\u591f\u5728\u5c0f\u9f20\u7684\u6dcb\u5df4\u7ed3\u4e2d\u8bf1\u5bfcTfh\u548c\u751f\u53d1\u4e2d\u5fc3\u7684\u5f62\u6210\uff0c\u7136\u800c\u8fd9\u79cd\u6548\u5e94\u5728\u4eba\u7c7b\u4e2d\u4ecd\u7136\u662f\u672a\u77e5\u7684\uff0c\u5c3d\u7ba1\u4e00\u4e9b\u57fa\u4e8e\u5916\u5468\u8840\u4e2dTfh\u9891\u7387\u7684\u521d\u6b65\u7814\u7a76\u8868\u660e\u60c5\u51b5\u786e\u5b9e\u5982\u6b64\u3002\u4f50\u5242\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u57fa\u4e8eTLR\u6fc0\u52a8\u5242\u7684\u4f50\u5242\uff0c\u4e4b\u95f4\u5b58\u5728\u660e\u786e\u7684\u5dee\u5f02\uff0c\u8fd9\u4e9b\u5dee\u5f02\u662f\u57fa\u4e8e\u76f8\u5173\u53d7\u4f53\u5728\u67d0\u4e9b\u7ec6\u80de\u7fa4\u4f53\u4e0a\u7684\u5b58\u5728\u6216\u7f3a\u5931\u7684\u3002\u4f8b\u5982\uff0cAS04\u4e0d\u80fd\u76f4\u63a5\u4f5c\u7528\u4e8eB\u7ec6\u80de\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u7ec6\u80de\u7f3a\u4e4fTLR4\uff0c\u8fd9\u8868\u660e\u5b83\u4eec\u5bf9B\u7ec6\u80de\u53cd\u5e94\u7684\u514d\u75ab\u589e\u5f3a\u5fc5\u987b\u901a\u8fc7\u6fc0\u6d3bT\u7ec6\u80de\u6765\u4ecb\u5bfc\u3002\u800c\u6c34\u5305\u6cb9\u4f50\u5242\u7684\u60c5\u51b5\u53ef\u80fd\u4e0d\u540c\uff0c\u56e0\u4e3a\u5df2\u77e5MF59\u53ef\u4ee5\u6fc0\u6d3b\u521d\u59cb\u548cMBC\uff0c\u5e76\u80fd\u591f\u663e\u7740\u6269\u5927\u5bf9\u79bd\u6d41\u611fH5N1\u6216\u5927\u6d41\u884cH1N1\u6d41\u611f\u75c5\u6bd2\u7279\u5f02\u6027\u7684\u9884\u5148\u5b58\u5728\u7684MBC\u5e93\u3002<\/span><\/p>\n

\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5728\u7528\u4f50\u5242\u75ab\u82d7\u63a5\u79cd\u75ab\u82d7\u540e\u5b9a\u4e49\u7684\u53c2\u6570\u6216\u76f8\u5173\u6027\u5927\u591a\u6570\u90fd\u662f\u4e0e\u7fa4\u4f53\u76f8\u5173\u7684\uff0c\u5f88\u5c11\u4ece\u4e2a\u4f53\u7684\u89d2\u5ea6\u51fa\u53d1\u3002\u4f8b\u5982\uff0c\u4fdd\u62a4\u7684\u76f8\u5173\u5173\u7cfb\u9002\u7528\u4e8e\u4e2a\u4eba\uff0c\u56e0\u4e3a\u5b83\u4eec\u53ef\u4ee5\u786e\u5b9a\u4e00\u4e2a\u7279\u5b9a\u7684\u4eba\u80fd\u5426\u591f\u88ab\u9488\u5bf9\u67d0\u79cd\u7279\u5b9a\u7684\u75be\u75c5\u5f97\u5230\u4fdd\u62a4\u3002\u8fd9\u9002\u7528\u4e8e\u6210\u719f\u7684\u75ab\u82d7\uff0c\u4f8b\u5982\u9488\u5bf9\u7834\u4f24\u98ce\u3001\u767d\u5589\u3001HBV\u3001Hib\u7b49\u7684\u75ab\u82d7\u3002\u4e0d\u53ef\u5426\u8ba4\u7684\u662f\uff0c\u76ee\u524d\u8fd8\u6709\u5f88\u591a\u5176\u4ed6\u7684\u4f50\u5242\u75ab\u82d7\u7684\u4fdd\u62a4\u529b\u548c\u53cd\u5e94\u6027\u7684\u76f8\u5173\u6807\u8bb0\u7269\u5c1a\u65e0\u6cd5\u5728\u4e2a\u4f53\u6c34\u5e73\u4e0a\u5b9a\u4e49\u3002\u5b9e\u9645\u4e0a\uff0c\u5728\u8fc4\u4eca\u4e3a\u6b62\u4f7f\u7528\u57fa\u56e0\u8c31\u5206\u6790\u6216\u5176\u4ed6\u7cfb\u7edf\u751f\u7269\u5b66\u65b9\u6cd5\u8fdb\u884c\u7684\u5927\u591a\u6570\u7814\u7a76\u4e2d\uff0c\u91cd\u8981\u7684\u53d8\u5f02\u6027\u4e00\u76f4\u5728\u4e2a\u4f53\u95f4\u6c34\u5e73\u4e0a\u663e\u793a\u51fa\u6765\u3002\u8fd9\u79cd\u53ef\u53d8\u6027\u4f7f\u6211\u4eec\u5f97\u5f88\u96be\u76f4\u63a5\u5c06\u8fd9\u4e9b\u4fe1\u606f\u8f6c\u5316\u4e3a\u65b0\u578b\u4f50\u5242\u75ab\u82d7\u6709\u6548\u6027\u548c\/\u6216\u5b89\u5168\u6027\u7684\u9884\u6d4b\u56e0\u5b50\u3002\u8fd9\u4e9b\u65b9\u9762\u5bf9\u4e8e\u66f4\u597d\u5730\u7406\u89e3\u673a\u7406\u975e\u5e38\u91cd\u8981\uff0c\u5728\u5f00\u53d1\u65b0\u7684\u4f50\u5242\u548c\u4f50\u5242\u75ab\u82d7\u65f6\u5fc5\u987b\u52a0\u4ee5\u8003\u8651\u3002<\/span><\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/p>\n

Del Giudice G, Rappuoli R, Didierlaurent AM.Correlates of adjuvanticity: A review on adjuvants in licensed vaccines.Semin Immunol. 2018 May 22. pii: S1044-5323(18)30051-4.<\/span><\/p>\n

\u4f1a\u8bae\u63a8\u8350<\/span><\/strong><\/span><\/p>\n

<\/strong><\/a><\/p>\n

\u201c\u5982\u4f55\u964d\u4f4e\u548c\u5e94\u5bf9\u5b9e\u9a8c\u5ba4OOS\/OOT\u201d\uff08\u6d4e\u5357\uff09\u6280\u672f\u4ea4\u6d41\u4f1a\u7684\u901a\u77e5<\/strong><\/a><\/strong><\/a><\/p>\n

\u4e0a\u6d77\u7ad9|\u836f\u54c1\u751f\u4ea7\u5de5\u827a\u53d8\u66f4\u7814\u7a76\u53ca\u5de5\u827a\u53d8\u66f4\u9a8c\u8bc1\u5b9e\u65bd<\/strong><\/a><\/p>\n

\u57f9\u8bad\u901a\u77e5|2018 CFDA\u300a\u836f\u54c1\u6570\u636e\u7ba1\u7406\u89c4\u8303\u300b\u89e3\u8bfb\u4e0e\u6848\u4f8b\u89e3\u6790<\/strong><\/a><\/p>\n

\u6210\u90fd\u7ad9|\u57fa\u4e8e\u98ce\u9669\u548c\u8bbe\u8ba1\u7684\u836f\u54c1\u65e0\u83cc\u4fdd\u8bc1\u63aa\u65bd\uff08\u7b2c\u4e00\u671f\uff09<\/a><\/strong><\/p>\n

\u3010\u53f7\u5916\u53f7\u5916\u3011\u6297\u4f53\u836f\u7814\u53d1\u73b0\u72b6\u53ca\u7acb\u9879\u89e3\u6790\uff08\u7b2c\u4e00\u671f\uff09<\/a><\/strong><\/p>\n

\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u751f\u7269\u5236\u54c1\u5708\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong>
<\/p>\n

\n
\n

\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n

\"\u5e72\u8d27|\u4f50\u5242\u6d3b\u6027\u7684\u76f8\u5173\u56e0\u7d20\uff1a\u83b7\u6279\u75ab\u82d7\u4e4b\u4f50\u5242\u7efc\u8ff0\"<\/p>\n

\n
\n
\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
<\/section>\n
<\/section>\n<\/section>\n
\n
\n
<\/span><\/strong><\/span>\u7248<\/section>\n<\/section>\n
\n
\u6743<\/section>\n<\/section>\n
\n
\u58f0<\/section>\n<\/section>\n
\n
\u660e<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u7248\u6743\u4e3a\u751f\u7269\u5236\u54c1\u5708\u6240\u6709\u3002\u6b22\u8fce\u4e2a\u4eba\u8f6c\u53d1\u5206\u4eab\u3002\u5176\u4ed6\u4efb\u4f55\u5a92\u4f53\u3001\u7f51\u7ad9\u5982\u9700\u8f6c\u8f7d\u6216\u5f15\u7528\u672c\u7f51\u7248\u6743\u6240\u6709\u5185\u5bb9\u987b\u83b7\u5f97\u6388\u6743\u4e14\u5728\u9192\u76ee\u4f4d\u7f6e\u5904\u6ce8\u660e\u201c\u8f6c\u81ea\uff1a\u751f\u7269\u5236\u54c1\u5708\u201d\u3002<\/span><\/p>\n

\n

\"\u5e72\u8d27|\u4f50\u5242\u6d3b\u6027\u7684\u76f8\u5173\u56e0\u7d20\uff1a\u83b7\u6279\u75ab\u82d7\u4e4b\u4f50\u5242\u7efc\u8ff0\"<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u751f\u7269\u5236\u54c1\u5708 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u6458\u8981 \u5728\u7ecf\u5386\u4e86\u51e0\u5341\u5e74\u7684\u7f13\u6162\u8fdb\u5c55\u540e\uff0c\u6700\u8fd1\u51e0\u5e74\u5185\u4f50\u5242\u75ab\u82d7\u7684\u5f00\u53d1\u7684\u8fc5\u901f\u53d1\u5c55\uff0c\u5e76\u5df2\u7ecf\u4f5c\u4e3a\u4eba\u7528\u75ab\u82d7\u88ab\u6279\u51c6\u3002\u8fd9\u4e9b\u4f50\u5242\u542b\u4e0d\u540c […]<\/p>\n","protected":false},"author":1,"featured_media":18605,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/18604"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=18604"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/18604\/revisions"}],"predecessor-version":[{"id":18612,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/18604\/revisions\/18612"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/18605"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=18604"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=18604"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=18604"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}