{"id":18965,"date":"2018-07-20T01:00:00","date_gmt":"2018-08-08T01:08:01","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/08\/%e6%94%b6%e8%97%8f%e6%ba%b6%e7%98%a4%e7%97%85%e6%af%92%e5%9b%bd%e5%86%85%e5%a4%96%e8%bf%9b%e5%b1%95\/"},"modified":"2018-08-08T09:08:06","modified_gmt":"2018-08-08T01:08:06","slug":"%e6%94%b6%e8%97%8f%e6%ba%b6%e7%98%a4%e7%97%85%e6%af%92%e5%9b%bd%e5%86%85%e5%a4%96%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/18965\/","title":{"rendered":"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55"},"content":{"rendered":"
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1.\u6eb6\u7624\u75c5\u6bd2\u4e3a\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u91cd\u8981\u65b9\u5411<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n

1.1 <\/span>\u514d\u75ab\u7597\u6cd5\u4e3a\u80bf\u7624\u6cbb\u7597\u9769\u547d\u6027\u7406\u5ff5<\/span><\/span><\/p>\n

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\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1aGlobocan2012\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406      <\/span><\/p>\n

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\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/p>\n

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\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a<\/span>Zion Market Research<\/span>\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/span><\/p>\n

1.2 \u6eb6\u7624\u75c5\u6bd2\u4e3a\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u65b0\u79c0\uff0c\u5df2\u6709\u4ee3\u8868\u6027\u4ea7\u54c1\u83b7\u6279<\/span><\/p>\n

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\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/p>\n

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\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1aCancer Sci\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/p>\n

\u53e6\u5916\uff0c\u968f\u7740\u5bf9\u764c\u75c7\u7279\u5f81\u7684\u4e0d\u65ad\u7814\u7a76\u548c\u75c5\u6bd2\u6539\u9020\u6280\u672f\u7684\u4e0d\u65ad\u6210\u719f\uff0c\u9776\u5411\u6027\u66f4\u597d\u3001\u6740\u4f24\u6548\u7387\u66f4\u9ad8\u7684\u65b0\u7684\u6eb6\u7624\u75c5\u6bd2\u54c1\u79cd\u4e5f\u5728\u4e0d\u65ad\u6d8c\u73b0\u3002\u4f8b\u5982\uff0c\u67ef\u8428\u5947\u75c5\u6bd2CAVATAK\uff08CVA21\uff09\u53ef\u7279\u5f02\u6027\u7ed3\u5408\u9ad8\u8868\u8fbeICAM-1\uff08intercellular adhesion molecule-1\uff09\u86cb\u767d\u7684\u764c\u7ec6\u80de\uff1b\u6539\u9020\u7684\u817a\u75c5\u6bd2Ad5\/3-\u039424\uff0c\u53ef\u4ee5\u7279\u5f02\u6027\u7ed3\u5408\u5375\u5de2\u764c\u4e2d\u9ad8\u8868\u8fbe\u7684\u6574\u5408\u7d20\uff08integrins\uff09\uff1bSG7011let7T \u5c06\u817a\u75c5\u6bd2\u590d\u5236\u86cb\u767dE1A \u5e26\u4e0a\u5728\u6b63\u5e38\u7ec6\u80de\u4e2d\u9ad8\u8868\u8fbe\u800c\u80bf\u7624\u7ec6\u80de\u4e2d\u4f4e\u8868\u8fbe\u7684microRNA \u7684\u9776\u6807\u5e8f\u5217\u4f7fE1A\u5728\u6b63\u5e38\u7ec6\u80de\u4e2d\u88ab\u964d\u89e3\uff0c\u5728\u764c\u7ec6\u80de\u4e2d\u7279\u5f02\u9ad8\u8868\u8fbe\uff0c\u4ece\u800c\u8fbe\u5230\u5728\u764c\u7ec6\u80de\u4e2d\u7279\u5f02\u6027\u590d\u5236\u7b49\u3002<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a\u516c\u5f00\u8d44\u6599\uff0cclinicaltrails\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/p>\n

\u76ee\u524d\u5df2\u67093 \u4e2a\u6eb6\u7624\u75c5\u6bd2\u4ea7\u54c1\u83b7\u6279\u4e0a\u5e02\uff0c\u5176\u4e2dT-vec (Talimogene laherparepvec, Imlygic)\u662f\u76ee\u524dFDA \u6279\u51c6\u4e0a\u5e02\u7684\u552f\u4e00\u4e00\u4e2a\u6eb6\u7624\u75c5\u6bd2\u4ea7\u54c1\uff0c\u57282015 \u5e7410 \u6708\u83b7\u6279\u4e0a\u5e02\u7528\u4e8e\u665a\u671f\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7597\u3002\u53e6\u5916\u67096 \u4e2a\u6eb6\u7624\u75c5\u6bd2\u4ea7\u54c1\u5904\u4e8eIII \u671f\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\u3002<\/span><\/p>\n

1.3 <\/span>\u6eb6\u7624\u75c5\u6bd2\u8054\u7528\u83b7\u7597\u6548\u7a81\u7834\uff0c\u6709\u671b\u83b7\u5f97\u66f4\u597d\u7684\u6cbb\u7597\u6548\u679c<\/span><\/span><\/p>\n

2015 \u5e7410 \u6708\uff0cFDA \u6279\u51c6T-vec\uff08Talimogene laherparepvec, Imlygic\uff09\u7528\u4e8e\u624b\u672f\u5207\u9664\u540e\u590d\u53d1\u7684\u9ed1\u8272\u7d20\u7624\u7684\u4e0d\u53ef\u5207\u9664\u75c5\u7076\u7684\u5c40\u90e8\u6cbb\u7597\uff0c\u662fFDA \u6279\u51c6\u7684\u7b2c\u4e00\u4e2a\u6eb6\u7624\u75c5\u6bd2\u7597\u6cd5\u3002\u4f46\u7531\u4e8e\u6cbb\u7597\u6548\u679c\u53ca\u9002\u5b9c\u4eba\u7fa4\u8f83\u5c11\u7b49\u539f\u56e0\u5bfc\u81f4\u8be5\u4ea7\u54c1\u5e76\u672a\u53d6\u5f97\u826f\u597d\u7684\u9500\u552e\u5e02\u573a\u3002<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a<\/span>Bloomberg<\/span>\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/span><\/p>\n

\u4f46\u662f\uff0c\u6eb6\u7624\u75c5\u6bd2\u7597\u6cd5\u7531\u4e8e\u5176\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u591a\u9014\u5f84\u6740\u4f24\u80bf\u7624\u7684\u673a\u5236\uff0c\u4f7f\u5f97\u5176\u5728\u80bf\u7624\u8054\u5408\u7528\u836f\u9886\u57df\u5b58\u5728\u5de8\u5927\u7684\u5e02\u573a\u6f5c\u529b\u3002\u8fd1\u671f\u6eb6\u7624\u75c5\u6bd2\u4e0e\u5176\u4ed6\u6297\u764c\u836f\u7269\u7684\u8054\u5408\u7528\u836f\u7684\u5b9e\u9a8c\u7ed3\u679c\u63a5\u8fde\u516c\u5e03\uff0c\u6eb6\u7624\u75c5\u6bd2\u5728\u8054\u5408\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7b49\u65b9\u9762\u90fd\u663e\u73b0\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6548\u679c\u3002\u751a\u81f3\u5728PD-1 \u6291\u5236\u5242\u6cbb\u7597\u6548\u679c\u4e0d\u4f73\u7684\u4e09\u9634\u6027\u4e73\u817a\u764c\u548c\u8111\u7624\u4e2d\u4e5f\u663e\u793a\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6548\u679c\uff08\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u5bf9\u4e09\u9634\u6027\u4e73\u817a\u764c\u7684\u6cbb\u6108\u7387\u8fbe90%\uff09\uff0c\u98a0\u8986\u4e86\u4e1a\u5185\u5bf9\u6eb6\u7624\u75c5\u6bd2\u6cbb\u7597\u6548\u679c\u4e0d\u770b\u597d\u7684\u4f20\u7edf\u8ba4\u8bc6\u3002<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/p>\n

\u6570\u636e\u6765\u6e90\uff1aPubmed\uff0cClinicaltrials\uff0c\u5404\u516c\u53f8\u516c\u544a\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/p>\n

\u4ee5\u5177\u6709\u76f8\u5bf9\u53ef\u6bd4\u4e34\u5e8a\u6570\u636e\u7684\u665a\u671f\u6076\u6027\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7597\u4e3a\u4f8b\uff0cT-vec \u4e0ePD-1 \u6291\u5236\u5242\u8054\u5408\u7528\u836f\u53ef\u4f7f\u6709\u6548\u7387\u7ffb\u500d\uff0c\u8fbe62%\uff0c\u75be\u75c5\u63a7\u5236\u7387\u8fbe\u523076%\uff0c\u5e76\u4e14\u526f\u4f5c\u7528\u5c0f\u3002<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a<\/span>Lancet Oncol<\/span>\uff0c<\/span>ESMO-2017-Congress<\/span>\uff0c<\/span>Cell<\/span>\uff0c<\/span>clinicaltrails<\/span>\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/span><\/p>\n

\n
\n
\n
2.\u6eb6\u7624\u75c5\u6bd2\uff1a\u767e\u5e74\u53d1\u5c55\uff0c\u5546\u4e1a\u5316\u7206\u53d1\u5728\u5373<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u76ee\u524d\u4e34\u5e8a\u7814\u7a76\u8f83\u591a\u7684\u5927\u90e8\u5206\u662f\u7ecf\u8fc7\u57fa\u56e0\u6539\u9020\u7684\u6eb6\u7624\u75c5\u6bd2\uff0c\u5982\u817a\u75c5\u6bd2\u3001\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2\u3001\u75d8\u75c5\u6bd2\u3001\u67ef\u8428\u5947\u75c5\u6bd2\u3002\u4e5f\u6709\u5c11\u6570\u5929\u7136\u7684\u672a\u7ecf\u6539\u9020\u7684\u6eb6\u7624\u75c5\u6bd2\uff0c\u5982\u547c\u80a0\u5b64\u75c5\u6bd2\u3002\u5176\u4e2d\u4ee5\u57fa\u56e0\u6539\u9020\u540e\u7684\u817a\u75c5\u6bd2\u548c\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2\u7814\u7a76\u6700\u5e7f\u3002<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a<\/span>Nature<\/span>\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/span><\/p>\n

2.1 \u6eb6\u7624\u75c5\u6bd2\u7ecf\u5386\u767e\u5e74\u53d1\u5c55\uff0c\u76ee\u524d\u6280\u672f\u6210\u719f\uff0c\u7597\u6548\u88ab\u8ba4\u53ef<\/span><\/p>\n

\u5229\u7528\u75c5\u6bd2\u6cbb\u7597\u80bf\u7624\u7684\u6982\u5ff5\u5df2\u6709100 \u591a\u5e74\u7684\u5386\u53f2\uff0c\u65e9\u57281904 \u5e74\uff0c\u5c31\u6709\u62a5\u9053\u4e00\u4f4d42 \u5c81\u6362\u767d\u8840\u75c5\u7684\u5973\u6027\u56e0\u611f\u67d3\u6d41\u611f\u800c\u4f7f\u80bf\u7624\u6709\u6240\u6d88\u9000\u3002\u4e4b\u540e\u57281912 \u5e74\uff0c\u610f\u5927\u5229\u533b\u751f\u53d1\u73b0\u6ce8\u5c04\u72c2\u72ac\u75c5\u6bd2\u75ab\u82d7\u53ef\u4ee5\u5f15\u8d77\u5bab\u9888\u764c\u6d88\u9000\uff0c\u7531\u6b64\u8bde\u751f\u4e86\u6eb6\u7624\u75c5\u6bd2\u7597\u6cd5\u8fd9\u4e00\u65b0\u5174\u6982\u5ff5\u548c\u4e00\u7cfb\u5217\u76f8\u5173\u7814\u7a76\u3002\u4e0a\u4e16\u7eaa50 \u5e74\u4ee3\u523070 \u5e74\u4ee3\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u5c55\u4e86\u5927\u91cf\u7684\u5229\u7528\u91ce\u751f\u578b\u75c5\u6bd2\u6cbb\u7597\u80bf\u7624\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f46\u662f\u7531\u4e8e\u5f53\u65f6\u6280\u672f\u548c\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u6240\u9650\uff0c\u867d\u7136\u6eb6\u7624\u75c5\u6bd2\u5728\u4e34\u5e8a\u8bd5\u9a8c\u5c55\u793a\u51fa\u4e00\u5b9a\u7684\u6297\u80bf\u7624\u6548\u679c\uff0c\u4f46\u7531\u4e8e\u65e0\u6cd5\u6709\u6548\u63a7\u5236\u75c5\u6bd2\u7684\u75c5\u539f\u6027\uff0c\u6eb6\u7624\u75c5\u6bd2\u4e00\u76f4\u5904\u4e8e\u764c\u75c7\u7597\u6cd5\u7684\u6b21\u8981\u5730\u4f4d\u3002<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1aPubmed\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/p>\n

\u76f4\u5230\u4e0a\u4e16\u7eaa80 \u5e74\u4ee3\uff0c\u57fa\u56e0\u5de5\u7a0b\u6280\u672f\u7684\u51fa\u73b0\u4f7f\u6539\u9020\u75c5\u6bd2\u57fa\u56e0\u7ec4\u6210\u4e3a\u53ef\u80fd\uff0c\u968f\u540e\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\u7684\u51cf\u6bd2\u548c\u9ad8\u9009\u62e9\u6027\u7684\u75c5\u6bd2\u51fa\u73b0\u30021991 \u5e74\uff0c\u4e34\u5e8a\u524d\u52a8\u7269\u5b9e\u9a8c\u62a5\u9053\u4e86\u80f8\u82f7\u6fc0\u9176(Thymidinekinase ,TK)\u6572\u9664\u7684\u57fa\u56e0\u6539\u9020\u4eba\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2I\uff08HSV-1\uff09\u53ef\u4ee5\u5728\u5c0f\u9f20\u4f53\u5185\u6291\u5236\u80f6\u8d28\u7624\u7684\u751f\u957f\uff0c\u5ef6\u957f\u5c0f\u9f20\u751f\u5b58\u671f\uff0c\u5e76\u4e14\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u3002<\/span><\/p>\n

1996 \u5e74\uff0c\u57fa\u56e0\u6539\u9020\u7684\u817a\u75c5\u6bd2ONYX-015 \u8fdb\u5165I \u671f\u4e34\u5e8a\u8bd5\u9a8c\u30022004 \u5e74\uff0cRIGVIR\uff0c\u4e00\u6b3e\u975e\u81f4\u75c5\u6027\u7684\u4eba\u80a0\u9053\u7ec6\u80de\u75c5\u53d8\u5b64\u513f\u75c5\u6bd2\uff08enteric cytopathic human orphan virus\uff09\u5728\u62c9\u8131\u7ef4\u4e9a\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\uff0c\u6210\u4e3a\u7b2c\u4e00\u6b3e\u83b7\u5f97\u76d1\u7ba1\u673a\u6784\u6279\u51c6\u7684\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u6eb6\u7624\u75c5\u6bd2\u30022005 \u5e74\uff0c\u6539\u9020\u7684\u817a\u75c5\u6bd2H101\uff08Oncorine\uff0c\u91cd\u7ec4\u4eba5 \u578b\u817a\u75c5\u6bd2\u6ce8\u5c04\u6db2\uff0c\u5b89\u67ef\u745e\uff09\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u4f46\u4e34\u5e8a\u7597\u6548\u76ee\u524d\u8fd8\u672a\u5f97\u5230\u56fd\u9645\u8ba4\u53ef\u3002<\/span><\/p>\n

2015 \u5e7410 \u6708\uff0cFDA \u6279\u51c6T-vec\uff08Talimogene laherparepvec, Imlygic\uff09\u7684\u4e0a\u5e02\uff0c2016\u5e74\u53c8\u5206\u522b\u5728\u6b27\u6d32\u548c\u52a0\u62ff\u5927\u83b7\u6279\u4e0a\u5e02\uff0c\u6807\u5fd7\u6eb6\u7624\u75c5\u6bd2\u6280\u672f\u7684\u6210\u719f\u548c\u5bf9\u6eb6\u7624\u75c5\u6bd2\u6cbb\u7597\u764c\u75c7\u7684\u6b63\u5f0f\u8ba4\u53ef\u3002<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a<\/span>Pubmed<\/span>\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/span><\/p>\n

2.2 \u591a\u79cd\u8def\u5f84\u6740\u4f24\u80bf\u7624\u7ec6\u80de\uff0c\u6eb6\u7624\u75c5\u6bd2\u662f\u4e00\u79cd\u53ef\u7f16\u7a0b\u7684\u201c\u6d3b\u836f\u201d<\/span><\/p>\n

\u6eb6\u7624\u75c5\u6bd2\u662f\u4e00\u79cd\u53ef\u7f16\u7a0b\u7684\u201c\u6d3b\u836f\u201d\uff0c\u53ef\u4ee5\u901a\u8fc7\u591a\u79cd\u8def\u5f84\u6765\u6740\u4f24\u80bf\u7624\uff0c\u6709\u6548\u907f\u514d\u8010\u836f\u6027\u3002\u76ee\u524d\u8ba4\u4e3a\u6eb6\u7624\u75c5\u6bd2\u6740\u4f24\u80bf\u7624\u4e3b\u8981\u6709\u4e09\u65b9\u9762\u4f5c\u7528\u673a\u5236\uff1a<\/span><\/p>\n

\uff081\uff09\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u7279\u5f02\u7e41\u6b96\uff0c\u76f4\u63a5\u88c2\u89e3\u764c\u7ec6\u80de\u3002\u4e00\u76f4\u52302000 \u5e74\u5de6\u53f3\uff0c\u79d1\u7814\u4eba\u5458\u8fd8\u5927\u591a\u4ee5\u4e3a\u8fd9\u662f\u75c5\u6bd2\u6740\u4f24\u80bf\u7624\u7684\u4e3b\u8981\u65b9\u5f0f\uff0c\u6eb6\u7624\u75c5\u6bd2\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u5355\u7eaf\u7684\u75c5\u6bd2\u7597\u6cd5\uff0c\u76f8\u5173\u5de5\u4f5c\u4e5f\u90fd\u96c6\u4e2d\u5728\u63d0\u9ad8\u75c5\u6bd2\u88c2\u89e3\u6548\u7387\u548c\u80bf\u7624\u7ec6\u80de\u9009\u62e9\u6027\u4e0a\u3002<\/span><\/p>\n

\uff082\uff092000 \u5e74\u540e\uff0c\u79d1\u7814\u4eba\u5458\u624d\u9010\u6e10\u53d1\u73b0\uff0c\u75c5\u6bd2\u53ef\u4ee5\u901a\u8fc7\u591a\u79cd\u9014\u5f84\uff08\u589e\u52a0\u80bf\u7624\u6297\u539f\u66b4\u9732\u3001\u8c03\u8282\u80bf\u7624\u5fae\u73af\u5883\u3001\u589e\u52a0\u80bf\u7624\u5fae\u73af\u5883\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u3001\u6d3b\u5316\u514d\u75ab\u7ec6\u80de\u3001\u901a\u8fc7\u643a\u5e26\u7684\u514d\u75ab\u8c03\u8282\u56e0\u5b50\u523a\u6fc0\u673a\u4f53\u514d\u75ab\u7cfb\u7edf\u7b49\uff09\u6765\u8bf1\u5bfc\u5168\u8eab\u7cfb\u7edf\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u6765\u6740\u4f24\u80bf\u7624\u3002\u56e0\u6b64\uff0c\u6eb6\u7624\u75c5\u6bd2\u7597\u6cd5\u5df2\u7ecf\u4ece\u4e00\u79cd\u5355\u7eaf\u7684\u80bf\u7624\u75c5\u6bd2\u7597\u6cd5\u5f52\u7c7b\u4e3a\u4e00\u79cd\u65b0\u578b\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u836f\u7269\uff0c\u57fa\u56e0\u6539\u9020\u601d\u8def\u4e5f\u53d1\u751f\u53d8\u5316\uff0c\u6bd4\u5982\uff0c\u5f00\u59cb\u5728\u6eb6\u7624\u75c5\u6bd2\u57fa\u56e0\u7ec4\u4e2d\u52a0\u5165\u4e00\u4e9b\u514d\u75ab\u8c03\u8282\u56e0\u5b50\u7684\u57fa\u56e0\uff08\u5982T-vec \u7684GM-CSF\uff09\u3002<\/span><\/p>\n

\uff083\uff09\u53e6\u5916\uff0c\u8fd8\u6709\u62a5\u9053\u8868\u660e\uff0c\u6709\u4e9b\u75c5\u6bd2\u53ef\u4ee5\u901a\u8fc7\u611f\u67d3\u80bf\u7624\u76f8\u5173\u7684\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\uff0c\u963b\u6b62\u80bf\u7624\u8840\u7ba1\u751f\u6210\uff0c\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u574f\u6b7b\u800c\u95f4\u63a5\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u3002<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"\u6570\u636e\u6765\u6e90\uff1a<\/span>Oncolytic Virotherapy<\/span>\uff0c<\/span>Frontiers in Immunology<\/span>\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/span><\/p>\n

\u6b64\u5916\uff0c\u6eb6\u7624\u75c5\u6bd2\u8fd8\u53ef\u4ee5\u505a\u591a\u79cd\u6539\u9020\uff0c\u4f5c\u4e3a\u8f7d\u4f53\u63d2\u5165\u6cbb\u7597\u6027\u57fa\u56e0\uff0c\u901a\u8fc7\u591a\u79cd\u9014\u5f84\u534f\u540c\u4f5c\u7528\u6740\u4f24\u80bf\u7624\u7ec6\u80de\uff0c\u53ef\u4ee5\u6709\u6548\u907f\u514d\u76ee\u524d\u5355\u4e00\u9776\u70b9\u6297\u764c\u836f\u7269\u666e\u904d\u5b58\u5728\u7684\u8010\u836f\u6027\u95ee\u9898\u3002\u76ee\u524d\u6709\u8fd1\u767e\u79cd\u5728\u7814\u7684\u5916\u6e90\u57fa\u56e0\uff0c\u4e3b\u8981\u5206\u56db\u7c7b\uff1a<\/span><\/p>\n

\uff081\uff09\u7ec6\u80de\u6b7b\u4ea1\u76f8\u5173\u5206\u5b50\uff08cell death related\uff09\uff0c\u53ef\u4ee5\u76f4\u63a5\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u7684\u6b7b\u4ea1\u3002\u5982\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u76f8\u5173\u51cb\u4ea1\u8bf1\u5bfc\u914d\u4f53\uff08TRAIL\uff09\uff0c\u6291\u764c\u57fa\u56e0P53 \u7b49\uff1b<\/span><\/p>\n

\uff082\uff09\u6297\u8840\u7ba1\u751f\u6210\u7684\u5206\u5b50\uff08anti-angiogenic\uff09\uff0c\u6291\u5236\u80bf\u7624\u7ec4\u7ec7\u8840\u7ba1\u751f\u6210\u3002\u5982\u5185\u76ae\u6291\u7d20\u3001\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u751f\u957f\u6291\u5236\u56e0\u5b50\uff08VEGI\uff09\uff1b<\/span><\/p>\n

\uff083\uff09\u514d\u75ab\u8c03\u8282\u56e0\u5b50\uff08immunomodulatory\uff09\uff0c\u5982\u514d\u75ab\u76f8\u5173\u7ec6\u80de\u56e0\u5b50\uff08GM-CSF\uff0cIL-2\uff0c\u5e72\u6270\u7d20\uff09\uff0c\u8d8b\u5316\u56e0\u5b50\uff08CCL5\uff0cCCL20\uff0cCCL21\uff09\uff0c\u5176\u4ed6\u53ef\u8bf1\u5bfc\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u56e0\u5b50\uff08\u75c5\u6bd2\u819c\u86cb\u767d\uff0cHSP70\uff09\u7b49\uff1b<\/span><\/p>\n

\uff084\uff09\u6291\u5236\u80bf\u7624\u76f8\u5173\u57fa\u56e0\u7684\u5c0fRNA \u5206\u5b50\uff08small RNA\uff09\uff0c\u5982miRNA\uff0csiRNA\uff0cshRNA \u548clncRNA \u7b49\u3002<\/span><\/p>\n

\n
\n
\n
3.\u836f\u7269\u8054\u7528+\u7ed9\u836f\u9014\u5f84\u7a81\u7834\uff0c\u5e02\u573a\u6216\u5c06\u8fce\u6765\u7206\u53d1\u62d0\u70b9<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n

3.1 \u8054\u5408\u7528\u836f\uff1a\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8054\u7528\uff0c\u6b63\u5e7f\u6cdb\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c<\/span><\/p>\n

\u968f\u7740\u4e34\u5e8a\u7814\u7a76\u7684\u4e0d\u65ad\u53d1\u5c55\uff0c\u8fd1\u4e24\u5e74\u6eb6\u7624\u75c5\u6bd2\u5728\u8054\u5408\u7528\u836f\u65b9\u9762\u4e0d\u65ad\u6709\u98a0\u8986\u6027\u4e34\u5e8a\u7597\u6548\u62a5\u9053\uff0c\u5c24\u5176\u4e0ePD-1 \u6291\u5236\u5242\u7684\u8054\u5408\u7528\u836f\u65b9\u9762\uff0c\u8bc1\u660e\u6709\u98a0\u8986\u6027\u4e34\u5e8a\u6548\u679c\uff0c\u526f\u4f5c\u7528\u5c11\u4e14\u53ef\u63a7\uff0c\u5e76\u4e14\u8054\u7528\u534f\u540c\u6548\u5e94\u4ea7\u751f\u7684\u673a\u5236\u4e5f\u9010\u6e10\u6e05\u6670\u3002\u53e6\u5916\uff0c\u6eb6\u7624\u75c5\u6bd2\u7ed9\u836f\u65b9\u5f0f\u4e5f\u4e0d\u65ad\u6709\u65b0\u7684\u7a81\u7834\uff0c\u4f7f\u5f97\u5176\u4ed6\u66f4\u4fbf\u6377\u7684\u7ed9\u836f\u65b9\u5f0f\uff08\u5982\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u7b49\uff09\u6210\u4e3a\u53ef\u80fd\uff0c\u6709\u5229\u4e8e\u6eb6\u7624\u75c5\u6bd2\u7528\u836f\u8303\u56f4\u7684\u6269\u5927\u3002<\/span><\/p>\n

\u80bf\u7624\u5f02\u8d28\u6027\u4e0b\uff0c\u8054\u5408\u7528\u836f\u4e3a\u884c\u4e1a\u8d8b\u52bf\u3002\u80bf\u7624\u4e0d\u662f\u5927\u91cf\u5b64\u7acb\u589e\u6b96\u7684\u764c\u7ec6\u80de\uff0c\u800c\u662f\u5f7c\u6b64\u4e4b\u95f4\u76f8\u4e92\u53c2\u4e0e\u5f02\u8d28\u6027\u4f5c\u7528\u7684\u3001\u7531\u591a\u4e2a\u4e0d\u540c\u7c7b\u578b\u7ec6\u80de\u6784\u6210\u7684\u590d\u5408\u7ec4\u7ec7\u3002\u7814\u7a76\u62a5\u9053\uff0c\u5373\u4f7f\u540c\u4e00\u5904\u80bf\u7624\u7684\u4e0d\u540c\u533a\u57df\u4e5f\u5177\u6709\u591a\u79cd\u9057\u4f20\u6a21\u5f0f\uff0c\u800c\u4e14\u764c\u7ec6\u80de\u8fd8\u4f1a\u4e0d\u65ad\u6539\u53d8\u5176\u9057\u4f20\u7ec4\u6210\u3002\u80bf\u7624\u7684\u8fd9\u79cd\u5f02\u8d28\u6027\u662f\u5f15\u53d1\u901a\u8fc7\u5355\u4e00\u9014\u5f84\u8d77\u4f5c\u7528\u7684\u836f\u7269\u4ea7\u751f\u6297\u836f\u6027\u548c\u7597\u6cd5\u5931\u8d25\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u800c\u591a\u9776\u70b9\u3001\u4e0d\u540c\u6297\u764c\u673a\u5236\u7684\u836f\u7269\u8054\u7528\u6709\u671b\u6539\u5584\u8fd9\u4e00\u95ee\u9898\uff0c\u662f\u76ee\u524d\u6297\u80bf\u7624\u836f\u7269\u7684\u7814\u53d1\u70ed\u70b9\u3002\u6297\u764c\u836f\u7269\u8054\u7528\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5360\u6240\u6709\u6297\u764c\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6bd4\u4f8b\u8fdc\u9ad8\u4e8e\u8054\u5408\u7528\u836f\u5728\u5176\u4ed6\u75be\u75c5\u9886\u57df\u7684\u6bd4\u4f8b\u3002<\/span><\/p>\n

\u6eb6\u7624\u75c5\u6bd2\u56e0\u5176\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u591a\u79cd\u9014\u5f84\u7684\u6297\u764c\u673a\u5236\uff0c\u6210\u4e3a\u80bf\u7624\u8054\u5408\u7528\u836f\u7684\u826f\u597d\u9009\u62e9\u3002\u8fd1\u671f\u4e0d\u65ad\u6709\u6eb6\u7624\u75c5\u6bd2\u8054\u5408\u7528\u836f\u7684\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u516c\u5e03\uff0c\u8bc1\u660e\u6eb6\u7624\u75c5\u6bd2\u8054\u5408\u7528\u836f\u5177\u6709\u597d\u7684\u5b89\u5168\u6027\u548c\u98a0\u8986\u6027\u7597\u6548\u3002<\/span><\/p>\n

\u6eb6\u7624\u75c5\u6bd2\u5c24\u5176\u5728\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u8054\u5408\u7528\u836f\u4e2d\u4f53\u73b0\u4e86\u975e\u5e38\u597d\u7684\u7597\u6548\uff1a\u6eb6\u7624\u75c5\u6bd2\u5728\u5feb\u901f\u88c2\u89e3\u80bf\u7624\u7ec6\u80de\u7684\u540c\u65f6\u4f1a\u91ca\u653e\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\uff08tumor cell lysis and antigen release\uff09\uff0c\u8bf1\u53d1\u5168\u8eab\u6027\u7684\u6297\u80bf\u7624\u53cd\u5e94\uff0c\u589e\u52a0\u80bf\u7624\u7ec4\u7ec7\u5904\u7684\u5929\u7136\u514d\u75ab\u7cfb\u7edf\u7ec6\u80de\uff08\u5982NK \u7ec6\u80de\u3001\u541e\u566c\u7ec6\u80de\uff09\u6d78\u6da6\uff08Innate cell infiltration\uff09\u548cT \u7ec6\u80de\u6d78\u6da6\uff08T cell infiltration \uff09\uff0c\u4f46\u80bf\u7624\u5fae\u73af\u5883\u4f1a\u901a\u8fc7\u589e\u52a0\u8c03\u8282\u6027<\/span>T <\/span>\u7ec6\u80de\uff08\u201c\u6c49\u5978\u7ec6\u80de\u201d\uff09\u6216\u63d0\u9ad8\u80bf\u7624\u81ea\u8eab<\/span>PD-L1 <\/span>\u7684\u8868\u8fbe\u6765\u6291\u5236\u8fd9\u79cd\u7cfb\u7edf\u6027\u7684\u6297\u80bf\u7624\u53cd\u5e94\u3002\u800c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08<\/span>CTLA-4 <\/span>\u6297\u4f53\u3001<\/span>PD-1\/PD-L1<\/span>\u6297\u4f53\uff09\u53ef\u4ee5\u901a\u8fc7\u6e05\u9664\u8c03\u8282\u6027<\/span>T <\/span>\u7ec6\u80de\u3001\u6291\u5236<\/span>PD-1\/PD-L1 <\/span>\u7684\u6291\u5236\u4f5c\u7528\u800c\u6253\u7834\u8fd9\u79cd\u80bf\u7624\u5fae\u73af\u5883\u5bf9\u6297\u80bf\u7624\u514d\u75ab\u7684\u6291\u5236\uff0c\u8d77\u5230\u534f\u540c\u589e\u5f3a\u7684\u6548\u679c\u3002\u53e6\u5916\uff0c\u5728\u80bf\u7624\u88c2\u89e3\u91ca\u653e\u7684\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\u5bf9<\/span>T <\/span>\u7ec6\u80de\u7684\u6fc0\u6d3b\u8fc7\u7a0b\u4e2d\uff08\u5728\u6dcb\u5df4\u7ed3\u4e2d\u8fdb\u884c\uff0c<\/span>lymph node<\/span>\uff09\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8fd8\u53ef\u4ee5\u653e\u5927\u6297\u539f\u9012\u5448\u7ec6\u80de\u5bf9<\/span>T <\/span>\u7ec6\u80de\u7684\u6fc0\u6d3b\u4f5c\u7528\uff0c\u4ea7\u751f\u66f4\u591a\u6d3b\u6027\u7684<\/span>T<\/span>\u7ec6\u80de\u3002<\/span><\/span><\/p>\n

\u56fe12\uff1a\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u89e3\u9664\u6eb6\u7624\u75c5\u6bd2\u7597\u6cd5\u9650\u5236  <\/span><\/p>\n

\u56fe13:\uff1a\u6eb6\u7624\u75c5\u6bd2\u7597\u6cd5\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7597\u6cd5\u534f\u540c\u4e92\u8865<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1aClinical Cancer Research\uff0c\u516c\u5f00\u8d44\u6599\u6574\u7406\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/p>\n

\u6eb6\u7624\u75c5\u6bd2\u7684\u8054\u5408\u7528\u836f\u6709\u671b\u91ca\u653e\u6eb6\u7624\u75c5\u6bd2\u5de8\u5927\u7684\u5e02\u573a\u6f5c\u529b\u3002\u76ee\u524d\u9664\u4e86\u5df2\u83b7\u6279\u7684T-vec \u4e4b\u5916\uff0c\u5176\u4ed66 \u4e2a\u5904\u4e8eIII \u671f\u7684\u6eb6\u7624\u75c5\u6bd2\u4ea7\u54c1\u4e2d\uff0c\u67095 \u4e2a\uff08\u9664CG0070\uff09\u90fd\u5728\u8fdb\u884c\u8054\u5408\u7528\u836f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n

\u88686\uff1a\u76ee\u524d\u5904\u5728\u4e34\u5e8aIII \u671f\u7684\u6eb6\u7624\u75c5\u6bd2\u4ea7\u54c1\u6c47\u603b<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a<\/span>Clinicaltrials<\/span>\uff0c<\/span>Pubmed<\/span>\uff0c\u516c\u53f8\u516c\u544a\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/span><\/p>\n

\u65e9\u671f\u7684\u8054\u5408\u7528\u836f\u4e3b\u8981\u90fd\u662f\u4e0e\u4f20\u7edf\u80bf\u7624\u6cbb\u7597\u65b9\u5f0f\uff08\u653e\u3001\u5316\u7597\u7b49\uff09\u7684\u8054\u5408\u7528\u836f\uff0c\u968f\u7740\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u83b7\u6279\uff0c\u8fd1\u4e24\u5e74\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u8054\u5408\u7528\u836f\u5f00\u59cb\u5e7f\u6cdb\u8fdb\u884c\u3002<\/span><\/p>\n

\u56fe14\uff1a\u5df2\u4e0a\u5e02\u548c<\/span>III <\/span>\u671f\u4e34\u5e8a\u9636\u6bb5\u6eb6\u7624\u75c5\u6bd2\u836f\u7269\u7684\u8054\u5408\u7528\u836f\u4e34\u5e8a\u8bd5\u9a8c\u60c5\u51b5\uff08\u8bd5\u9a8c\u4e2a\u6570\uff0c\u622a\u81f3<\/span>2018<\/span>\u5e74<\/span>4<\/span>\u6708\uff09<\/span><\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1aClinicaltrials\uff0cPubmed\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/p>\n

\u4ee5\u5b89\u8fdb\u7684T-vec \u4e3a\u4f8b\uff0cT-vec \u76ee\u524d\u5728clinicaltrials.gov \u767b\u8bb0\u768433 \u4e2a\u6709\u6548\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u670916 \u4e2a\u662f\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u7528\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u4e2d8 \u9879\u662f\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u8054\u5408\u7528\u836f\u3002<\/span><\/p>\n

\u88687\uff1aT-vec \u767b\u8bb0\u6ce8\u518c\u7684\u836f\u7269\u8054\u7528\u4e34\u5e8a\u8bd5\u9a8c\u60c5\u51b5<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a<\/span>Clinicaltrials<\/span>\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/span><\/p>\n

3.2 <\/span>\u7ed9\u836f\u9014\u5f84\uff1a\u7a81\u7834\u53ef\u671f\uff0c\u9759\u8109\u6ce8\u5c04\u6f5c\u529b\u6700\u5927<\/span><\/span><\/p>\n

\u76ee\u524d\u6eb6\u7624\u75c5\u6bd2\u7684\u7ed9\u836f\u9014\u5f84\u4e3b\u8981\u4e3a\u7624\u5185\u6ce8\u5c04\uff0c\u56e0\u4e3a<\/span><\/p>\n

\uff081\uff09\u4eba\u4f53\u5185\u5e7f\u6cdb\u5b58\u5728\u8fd9\u4e9b\u5e38\u7528\u75c5\u6bd2\u7684\u819c\u53d7\u4f53\uff0c\u75c5\u6bd2\u611f\u67d3\u8fc7\u7a0b\u5e76\u65e0\u80bf\u7624\u7279\u5f02\u6027\uff1b<\/span><\/p>\n

\uff082\uff09\u4eba\u8840\u6e05\u4e2d\u4e5f\u5b58\u5728\u8fd9\u4e9b\u5e38\u89c1\u75c5\u6bd2\u7684\u7279\u5f02\u6297\u4f53\uff0c\u4f1a\u5f88\u5feb\u7684\u4e2d\u548c\u79fb\u9664\u8fd9\u4e9b\u75c5\u6bd2\uff1b<\/span><\/p>\n

\uff083\uff09\u8840\u6db2\u5bf9\u75c5\u6bd2\u7684\u7a00\u91ca\u4f5c\u7528\u3001\u80bf\u7624\u5fae\u73af\u5883\u6291\u5236\u75c5\u6bd2\u5bf9\u80bf\u7624\u7ec4\u7ec7\u7684\u6709\u6548\u6d78\u6da6\u7b49\u539f\u56e0\uff0c\u5bfc\u81f4\u6eb6\u7624\u75c5\u6bd2\u5f88\u96be\u7279\u5f02\u6027\u7684\u805a\u96c6\u5728\u80bf\u7624\u7ec4\u7ec7\u5904\u5e76\u8fbe\u5230\u6709\u6548\u6d53\u5ea6\u3002\u8fd9\u4e00\u7ed9\u836f\u65b9\u5f0f\u7684\u9650\u5236\uff0c\u4f7f\u5f97\u76ee\u524d\u6eb6\u7624\u75c5\u6bd2\u4e3b\u8981\u5e94\u7528\u5728\u79bb\u4f53\u8868\u8fd1\u7684\u3001\u4fbf\u4e8e\u624b\u672f\u7684\u764c\u75c7\u7c7b\u578b\u4e2d\uff0c\u5f00\u53d1\u66f4\u6709\u6548\u7684\u7ed9\u836f\u65b9\u5f0f\u624d\u80fd\u6269\u5927\u6eb6\u7624\u75c5\u6bd2\u7684\u5e94\u7528\u8303\u56f4\u3002<\/span><\/p>\n

\u6709\u5927\u91cf\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u5728\u5c1d\u8bd5\u6eb6\u7624\u75c5\u6bd2\u7684\u9759\u8109\u7ed9\u836f\u65b9\u5f0f\uff0c\u5982\u5bfb\u627e\u65b0\u578b\u7684\u75c5\u6bd2\u3001\u7528\u7eb3\u7c73\u6750\u6599\u5305\u88f9\u75c5\u6bd2\u7b49\u65b9\u5f0f\u3002\u76ee\u524d\u5df2\u6709\u8fd110 \u79cd\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\u5e76\u53d6\u5f97\u521d\u6b65\u7ed3\u679c\u7684\u53ef\u901a\u8fc7\u9759\u8109\u7ed9\u836f\u7684\u6eb6\u7624\u75c5\u6bd2\u4ea7\u54c1\uff0c\u5176\u4e2dReolysin \u5df2\u7ecf\u5b8c\u6210\u9759\u8109\u7ed9\u836f\u7684II \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u53d6\u5f97\u826f\u597d\u7684\u4e34\u5e8a\u7597\u6548\uff0c\u5373\u5c06\u8fdb\u5165\u4e34\u5e8aIII \u671f\uff0c\u6709\u671b\u6210\u4e3a\u7b2c\u4e00\u4e2a\u901a\u8fc7\u9759\u8109\u7ed9\u836f\u7684\u6eb6\u7624\u75c5\u6bd2\u4ea7\u54c1\u3002Enadenotucirev \u4e5f\u662f\u4e00\u6b3e\u4ee5\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u7684\u6eb6\u7624\u75c5\u6bd2\u4ea7\u54c1\uff0c\u6b63\u5728\u8fdb\u884c\u7684I \u671f\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u826f\u597d\u6548\u679c\u3002\u53e6\u5916\uff0c\u90e8\u5206\u7624\u5185\u6ce8\u5c04\u7684\u6eb6\u7624\u75c5\u6bd2\u4e5f\u5728\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u7684\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u7a76\u3002<\/span><\/p>\n

Reolysin<\/span><\/p>\n

Reolysin <\/span>\u662f\u53ef\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u7684\u5929\u7136\u6eb6\u7624\u75c5\u6bd2\uff08\u547c\u80a0\u5b64\u75c5\u6bd2\uff0cReovirus\uff09\u3002\u76ee\u524d\u6ce8\u518c\u768426 \u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d24 \u4e2a\u662f\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u65b9\u5f0f\u7ed9\u836f\u3002Reolysin \u57282015 \u5e74\u83b7\u5f97\u7f8e\u56fdFDA\u7684\u5b64\u513f\u836f\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u5375\u5de2\u764c\u3001\u80f0\u817a\u764c\u3001\u8f93\u5375\u7ba1\u7624\u548c\u6076\u6027\u80f6\u8d28\u7624\u3002\u8be5\u4ea7\u54c1\u6cbb\u7597\u665a\u671f\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u4e34\u5e8aII \u671f\u6570\u636e\u4e2d\uff0cReolysin \u4e0e\u7d2b\u6749\u9187(Paclitaxel)\u8054\u5408\u7528\u836f\u53ef\u4ee5\u6709\u6548\u5ef6\u957f\u60a3\u8005\u603b\u751f\u5b58\u671f\uff08\u4ece10.4 \u4e2a\u6708\u5ef6\u957f\u523017.4 \u4e2a\u6708\uff09\uff0c\u56e0\u6b64\u83b7\u5f97\u4e86FDA \u7528\u4e8e\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u6cbb\u7597\u5feb\u901f\u901a\u9053\u7684\u6307\u5b9a\u3002<\/span><\/span><\/p>\n

Enadenotucirev\uff08ColoAd1\uff09<\/span><\/strong><\/p>\n

Enadenotucirev\uff08ColoAd1\uff09\u4e5f\u662f\u53ef\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u7684\u6eb6\u7624\u75c5\u6bd2\uff0cEnadenotucirev \u662f\u4e00\u79cd\u901a\u8fc7\u5b9a\u5411\u8fdb\u5316\u7b5b\u9009\u7684\u3001\u5177\u6709\u66f4\u5f3a\u6297\u80bf\u7624\u6548\u679c\u548c\u8840\u6db2\u7a33\u5b9a\u6027\u7684\u975e\u5929\u7136\u5b58\u5728\u7684B \u7ec4Ad11p\/Ad3 \u5d4c\u5408\u817a\u75c5\u6bd2\uff0c\u7531\u4e8e\u5176\u7ecf\u8fc7\u5728\u65b0\u9c9c\u8840\u6db2\u5b58\u5728\u60c5\u51b5\u4e0b\u7684\u6740\u4f24\u80bf\u7624\u6548\u679c\u7b5b\u9009\uff0c\u7406\u8bba\u4e0a\u5177\u6709\u66f4\u597d\u7684\u9759\u8109\u6ce8\u5c04\u7a33\u5b9a\u6027\uff0c\u53ef\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u65b9\u5f0f\u7ed9\u836f\u3002<\/span><\/p>\n

\u56fe15\uff1a\u901a\u8fc7\u5b9a\u5411\u8fdb\u5316\u65b9\u5f0f\u7b5b\u9009\u83b7\u5f97<\/span>Enadenotucirev<\/span><\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a\u516c\u53f8\u5b98\u7f51\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/p>\n

\n
\n
\n
4. \u56fd\u9645\u6eb6\u7624\u75c5\u6bd2\u4ea7\u54c1<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n

Imlygic (talimogenelaherparepvec)\uff0c\u4fd7\u79f0T-vec\uff0c\u5373\u6297\u9ed1\u8272\u7d20\u7624\u4ea7\u54c1OncoVexGM-CSF \u6eb6\u7624\u75c5\u6bd2\u3002\u8be5\u836f\u7269\u5206106PFU\/mL \u548c108PFU\/mL \u4e24\u79cd\u6d53\u5ea6\uff0c\u4e8e2015 \u5e7410 \u6708\u5728\u7f8e\u56fd\u901a\u8fc7BLA \u6210\u4e3a\u9996\u4e2aFDA \u6279\u51c6\u4e0a\u5e02\u7684\u6eb6\u7624\u75c5\u6bd2\u4ea7\u54c1\u3002<\/span><\/p>\n

\u56fe16\uff1a\u7f8e\u56fd\u9ed1\u8272\u7d20\u7624\u53d1\u75c5\u60c5\u51b5          \u56fe17\uff1a\u7f8e\u56fd\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u6b7b\u4ea1\u60c5\u51b5<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90<\/span>\uff1aAmerican Cancer Society\uff0c<\/span>\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/span><\/p>\n

\u636e\u7f8e\u56fd\u75be\u75c5\u63a7\u5236\u4e0e\u9884\u9632\u4e2d\u5fc3\u62a5\u9053\uff0c\u7f8e\u56fd\u9ed1\u8272\u7d20\u7624\u53d1\u75c5\u7387\u9010\u5e74\u589e\u957f\uff0c2017-2018 \u5e74\u53d1\u75c5\u4eba\u6570\u9ad8\u8fbe9 \u4e07\uff0c\u800c\u6b7b\u4ea1\u7387\u5374\u5448\u4e0b\u6ed1\u8d8b\u52bf\uff0c\u5e76\u4e14\u4e94\u5e74\u5b58\u6d3b\u7387\u957f\u671f\u4fdd\u6301\u572891.5\uff05\uff0c\u8fd9\u6216\u591a\u6216\u5c11\u53d7\u76ca\u4e8e\u8fd1\u5e74\u6765\u533b\u836f\u9886\u57df\u5728\u751f\u7269\u836f\u3001\u9776\u5411\u836f\u7b49\u65b9\u9762\u4e0d\u65ad\u7684\u521b\u65b0\u548c\u53d1\u5c55\u3002\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\u6307\u51fa\u665a\u671f\u4e0d\u53ef\u5207\u9664\u590d\u53d1\u6027\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7597\u65b9\u9488\u5305\u62ec\u75c5\u7076\u5185\u6cbb\u7597\u3001\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u3001\u963b\u65ad\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u673a\u5236\u3001\u666e\u901a\u5316\u7597\u4ee5\u53ca\u59d1\u606f\u7597\u6cd5\uff0c\u800cT-Vec \u5219\u662f\u4e00\u6b3e\u878d\u5408\u4e86\u75c5\u7076\u5185\u6cbb\u7597\u548c\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u53cc\u91cd\u6982\u5ff5\u7684\u751f\u7269\u836f\uff0c\u5176\u76ee\u7684\u662f\u4e3a\u4e86\u8fbe\u5230\u5728\u88c2\u89e3\u764c\u7ec6\u80de\u7684\u540c\u65f6\u6fc0\u53d1\u4eba\u4f53\u81ea\u8eab\u514d\u75ab\u7cfb\u7edf\u6297\u764c\u80fd\u529b\u3002<\/span><\/p>\n

\u88688\uff1a\u7f8e\u56fd\u9ed1\u8272\u7d20\u7624\u6cbb\u7597\u6307\u5357<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a<\/span>NCI<\/span>\uff0c<\/span>FDA<\/span>\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/span><\/p>\n

\u88689\uff1a\u7f8e\u56fd\u9ed1\u8272\u7d20\u7624\u6cbb\u7597\u836f\u7269\u7b80<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span>
<\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/p>\n

\u6570\u636e\u6765\u6e90\uff1aNCI\uff0cFDA\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/p>\n

\u56fe18\uff1aT-Vec \u4f5c\u7528\u673a\u5236<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a\u516c\u53f8\u5b98\u7f51\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/p>\n

T-vec\uff08Imlygic\uff09\u662f\u4e00\u79cd\u57fa\u56e0\u6539\u9020\u540e\u7684HSV\uff08\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2\u3001Herpes Simplex Virus\uff09\u9776\u5411\u6eb6\u7624\u75c5\u6bd2\uff0cICP34.5 \u57fa\u56e0\u7684\u5254\u9664\u4f7f\u5b83\u53ea\u80fd\u5728\u764c\u7ec6\u80de\u4e2d\u590d\u5236\u5e76\u5c06\u5176\u88c2\u89e3\uff1b\u53e6\u5916\uff0cICP47 \u5254\u9664\u4ee5\u53caUS11\u3001GM-CSF \u7684\u63d2\u5165\u5728\u5f31\u5316\u4e86\u514d\u75ab\u7cfb\u7edf\u9003\u9038\u7684\u540c\u65f6\u589e\u5f3a\u4e86\u4eba\u4f53\u6811\u7a81\u7ec6\u80de\u7684\u6297\u764c\u80fd\u529b\u3002\u636e\u4e09\u671f\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0c\u75c5\u7076\u5185\u6ce8\u5c04Imlygic \u6eb6\u7624\u75c5\u6bd2\u4ea7\u751f\u7684\u6301\u4e45\u5e94\u7b54\u7387\u6bd4\u6ce8\u5c04\u5355\u4e00GM-CSF \u56e0\u5b50\u9ad8\u51fa14.2pp\uff0c\u6574\u4f53\u5e94\u7b54\u7387\u9ad8\u51fa20.7pp\uff0c\u6574\u4f53\u5b58\u6d3b\u7387\u8d85\u51fa4.4 \u4e2a\u6708\u3002<\/span><\/p>\n

\u6b64\u5916\uff0c\u8bb8\u591a\u5c1d\u8bd5T-Vec \u4e0e\u5176\u4ed6\u6297\u764c\u836f\u7269\u8054\u5408\u4f7f\u7528\u7684\u7814\u7a76\u6b63\u5728\u8fdb\u884c\u4e2d\u30022017 \u5e749 \u6708\u300aCell\u300b\u53d1\u8868\u7684\u4e00\u9879Ib \u671f\u6cbb\u7597\u665a\u671f\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u7684\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0cT-vec \u4e0eKeytruda(Pembrolizumab)\u7684\u8054\u5408\u7528\u836f\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u526f\u4f5c\u7528\u6ca1\u6709\u6bd4\u5355\u72ec\u7528\u836f\u4e25\u91cd\u3002\u4e24\u8005\u8054\u7528\u53ef\u4ee5\u6709\u6548\u6539\u5584\u80bf\u7624\u5fae\u73af\u5883\uff0c\u589e\u52a0\u80bf\u7624\u4e2dT \u7ec6\u80de\u7684\u6d78\u6da6\uff0c\u589e\u52a0\u80bf\u7624PD-L1 \u548cIFN-\u03b3\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u663e\u8457\u589e\u5f3a\u5bf9PD-1 \u6291\u5236\u5242\u7684\u5e94\u7b54\u6548\u7387\u3002\u8054\u7528\u7684\u603b\u5e94\u7b54\u7387\uff08ORR, overallresponse rate\uff09\u8fbe\u523062%\uff0c\u663e\u8457\u9ad8\u4e8e\u4e4b\u524d\u62a5\u9053\u7684\u4e24\u8005\u5355\u72ec\u7528\u836f\u768430%-40%\u3002\u5b8c\u5168\u5e94\u7b54\u7387\uff08CR,complete response rate\uff09\u8fbe\u523033%\uff0c\u610f\u5473\u7740\u4e09\u5206\u4e4b\u4e00\u7684\u60a3\u8005\u68c0\u6d4b\u4e0d\u5230\u80bf\u7624\u5b58\u5728\u3002\u8fd9\u9879\u7814\u7a76\u88ab\u8bc4\u4e3a\u300aCell\u300b2017 \u5e74\u5341\u4f73\u8bba\u6587\uff08\u201cBest of Cell 2017\u201d\uff09\uff0c\u518d\u6b21\u8bc1\u660e\u4e86\u6eb6\u7624\u75c5\u6bd2\u826f\u597d\u7684\u8054\u7528\u524d\u666f\u3002\u76ee\u524dT-vec \u67098 \u4e2a\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8054\u5408\u7528\u836f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u3002<\/span><\/p>\n

Pexa-Vec\uff08JX594\uff09\u5206\u522b\u83b7\u5f97\u6b27\u76dfEMA \u548c\u7f8e\u56fdFDA \u4f5c\u4e3a\u6cbb\u7597\u4e13\u9879\u653b\u514b\u809d\u764c\u7684\u5b64\u513f\u836f\u8ba4\u5b9a\u3002Pexa-Vec (JX-594)\u7531\u725b\u75d8\u75c5\u6bd2\u6539\u9020\u800c\u6765\u3002\u8be5\u4ea7\u54c1\u5728\u4ee5\u4e0b\u4e09\u4e2a\u65b9\u9762\u53d1\u6325\u4f5c\u7528\uff1a\uff081\uff09\u9009\u62e9\u6027\u611f\u67d3\u80bf\u7624\u7ec6\u80de\u5e76\u5728\u7ec6\u80de\u5185\u590d\u5236\u5bfc\u81f4\u5176\u6eb6\u89e3\uff1b\uff082\uff09\u901a\u8fc7\u611f\u67d3\u80bf\u7624\u7ba1\u8109\u7cfb\u7edf\u7ec6\u80de\uff0c\u51cf\u5c11\u80bf\u7624\u8840\u6db2\u4f9b\u5e94\uff1b\uff083\uff09\u901a\u8fc7\u6fc0\u6d3b\u4eba\u4f53\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u5e76\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u3002<\/span><\/p>\n

\u76ee\u524d\u5f00\u53d1Pexa-Vec\uff08JX594\uff09\u4e0ePD1 \u6291\u5236\u5242\u8054\u5408\u7528\u836f\u6b63\u5728\u5f00\u53d1\u4e2d\u3002<\/span><\/p>\n

\u56fe19\uff1a<\/span>JX-594 <\/span>\u6eb6\u7624\u4f5c\u7528\u539f\u7406       \u56fe20\uff1a<\/span>JX-584 <\/span>\u57fa\u56e0\u5de5\u7a0b\u8bbe\u8ba1<\/span><\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a\u516c\u53f8\u5b98\u7f51\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406  <\/span>                <\/span><\/p>\n

\u5177\u4f53\u5728\u75c5\u6bd2\u8bbe\u8ba1\u65b9\u9762\uff0cPexa-vec \u7684\u590d\u5236\u548c\u4f20\u64ad\u4f9d\u8d56\u4e8e\u80bf\u7624\u7ec6\u80de\u6fc0\u6d3b\u7684EGFR\/Raf\/Ras\u4fe1\u53f7\u901a\u8def\u3002\u4ee5\u53ca\uff0cPexa-vec \u4e2d\u80f8\u82f7\u6fc0\u9176(TK)\u57fa\u56e0\u88ab\u6572\u9664\uff0c\u800c\u5728\u589e\u6b96\u80fd\u529b\u5f3a\u7684\u764c\u7ec6\u80de\u4e2d\u80f8\u82f7\u6fc0\u9176\u9ad8\u8868\u8fbe\uff0c\u5728\u6b63\u5e38\u7ec6\u80de\u4e2d\u80f8\u82f7\u6fc0\u9176\u4f4e\u8868\u8fbe\uff0c\u56e0\u6b64Pexa-vec \u53ea\u80fd\u9009\u62e9\u6027\u7684\u5728\u764c\u7ec6\u80de\u4e2d\u590d\u5236\u3002\u6b64\u5916\uff0cPexa-vec \u8bbe\u8ba1\u8868\u8fbe\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\uff08GM-CSF\uff09\uff0c\u7528\u4e8e\u523a\u6fc0\u80bf\u7624\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\u3002<\/span><\/p>\n

\u53e6\u5916\uff0cPexa-Vec \u4e0e\u591a\u79cd\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08 Nivolumab\u3001Ipilimumab\u3001Cemiplimab\u3001Durvalumab\u3001Tremelimumab \u7b49\uff09\u8054\u7528\u7684\u3001\u91c7\u7528\u7624\u5185\u6ce8\u5c04\u6216\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u7684\u3001\u7528\u4e8e\u809d\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u80be\u764c\u3001\u80ba\u764c\u7b49\u7684\u4e34\u5e8aI\/II \u671f\u8bd5\u9a8c\u4e5f\u6b63\u5728\u8fdb\u884c\u3002<\/span><\/p>\n

CAVATAK <\/span>\u6eb6\u89e3\u80bf\u7624\u7279\u5f02\u6027\u5f3a\uff0c\u4e34\u5e8a\u8054\u5408\u7528\u836f\u6548\u679c\u663e\u8457\uff0cCAVATAK \u6216\u67ef\u8428\u5947\u75c5\u6bd2\uff08CVA21\uff09\u5177\u6709\u5728\u80bf\u7624\u90e8\u4f4d\u548c\u6574\u4e2a\u8eab\u4f53\u5185\u76f4\u63a5\u9776\u5411\u3001\u611f\u67d3\u3001\u7e41\u6b96\u548c\u7834\u574f\u5927\u8303\u56f4\u764c\u7ec6\u80de\u7684\u6f5c\u529b\u3002CAVATAK \u901a\u8fc7\u5bfb\u627e\u5e76\u9644\u7740\u4e8e\u5728\u764c\u7ec6\u80de\u8868\u9762\u9ad8\u5ea6\u8868\u8fbe\u7684\u86cb\u767d\u8d28\uff08ICAM-1\uff09\u800c\u8d77\u4f5c\u7528\u3002\u4e00\u65e6\u4e0e\u8be5\u86cb\u767d\u8d28\u8fde\u63a5\uff0c\u75c5\u6bd2\u5c31\u80fd\u591f\u5c06\u81ea\u8eab\u63d2\u5165\u764c\u7ec6\u80de\uff0c\u590d\u5236\u5e76\u5206\u88c2\u764c\u7ec6\u80de\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u79f0\u4e3a\u6eb6\u89e3\u3002\u5728\u6b64\u8fc7\u7a0b\u4e2d\uff0c\u80bf\u7624\u7ec6\u80de\u788e\u7247\u88ab\u91ca\u653e\u51fa\u6765\uff0c\u5e76\u6fc0\u6d3b\u4eba\u4f53\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u3002\u5177\u6709\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u5b89\u5168\u6027\u3002<\/span><\/span><\/p>\n

\u56fe21\uff1a<\/span>JX-584 <\/span>\u57fa\u56e0\u5de5\u7a0b\u8bbe\u8ba1<\/span><\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a\u516c\u53f8\u5b98\u7f51\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/p>\n

CAVATAK \u6709\u51e0\u4e2a\u91cd\u8981\u7684\u5c5e\u6027\uff0c\u5305\u62ec\uff1a<\/span><\/p>\n

\uff081\uff09\u9488\u5bf9\u5916\u90e8\u53d7\u4f53\u7684\u9776\u6807\uff0c\u4f18\u5148\u5728\u764c\u7ec6\u80de\u4e0a\u8fc7\u8868\u8fbe\uff1b<\/span><\/p>\n

\uff082\uff09\u6f5c\u5728\u5e94\u7528\u4e8e\u5404\u79cd\u764c\u75c7\u7c7b\u578b\uff0c\u5305\u62ec\u524d\u5217\u817a\u764c\uff0c\u80ba\u764c\uff0c\u9ed1\u8272\u7d20\u7624\u548c\u8180\u80f1\u764c\uff1b<\/span><\/p>\n

\uff083\uff09\u901a\u8fc7\u4e09\u79cd\u7ed9\u836f\u9014\u5f84\uff08\u75c5\u7076\u5185\uff0c\u9759\u8109\u5185\u548c\u8180\u80f1\u5185\uff09\u7684\u6f5c\u5728\u5e94\u7528\u5f00\u8f9f\u4e86\u5e94\u7528\u4e8e\u5e7f\u6cdb\u764c\u75c7\u7c7b\u578b\u7684\u6f5c\u529b\uff1b<\/span><\/p>\n

\uff084\uff09\u4f4e\u6bd2\u6027\uff0c\u5bf9\u60a3\u8005\u76843 \u7ea7\u6216\u66f4\u9ad8\u4e0d\u826f\u4e8b\u4ef6\u6c34\u5e73\u4f4e\uff1b<\/span><\/p>\n

\uff085\uff09\u4e0e\u73b0\u6709\u764c\u75c7\u6cbb\u7597\u7684\u6f5c\u5728\u534f\u540c\u4f5c\u7528\uff0c\u6709\u4e34\u5e8a\u524d\u548c\u65e9\u671f\u4e34\u5e8a\u8bc1\u636e\u8868\u660e\uff0cCAVATAK \u4e0e\u4e0b\u4e00\u4ee3\u4ea7\u54c1\uff08\u5982\u68c0\u67e5\u70b9\u6291\u5236\u5242YERVOY \u548cKEYTRUDA\uff09\u7ed3\u5408\u4f7f\u7528\u53ef\u589e\u52a0\u60a3\u8005\u7684\u4e34\u5e8a\u76ca\u5904\uff1b<\/span><\/p>\n

\uff086\uff09\u76f8\u5bf9\u4e8e\u66f4\u5927\u7684\u6eb6\u7624\u75c5\u6bd2\uff0cCAVATAK \u7684\u5c0f\u5c3a\u5bf8\uff0825 \u7eb3\u7c73\uff09\u548c\u65e0\u5305\u819c\u6027\u8d28\u4f7f\u5176\u80fd\u591f\u5728\u4f53\u5185\u4f20\u64ad\u5f97\u66f4\u5e7f\u6cdb\uff1b<\/span><\/p>\n

\uff087\uff09\u5feb\u901f\u590d\u5236\u5468\u671f\uff086 \u5c0f\u65f6\uff09\u53ef\u80fd\u5229\u4e8e\u66f4\u5feb\u901f\u7684\u54cd\u5e94\u3002<\/span><\/p>\n

CAVATAK \u8bf1\u5bfc\u7684\u80bf\u7624\u5fae\u73af\u5883\u53d8\u5316\u53ef\u4ee5\u5f15\u8d77\u5f3a\u70c8\u7684\u5c40\u90e8\u548c\u5168\u8eab\u6297\u80bf\u7624\u53cd\u5e94\u3002\u8fd9\u4e9b\u53d8\u5316\u5305\u62ec\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u7684\u589e\u52a0\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u5206\u5b50\u5982PD-L1 \u7684\u4e0a\u8c03\u3002\u901a\u8fc7\u8fd9\u4e9b\u9009\u62e9\u6027\u7684\u4f5c\u7528\u673a\u5236\uff0c\u8be5\u7597\u6cd5\u63d0\u4f9b\u66f4\u5927\u7684\u8010\u53d7\u6027\u548c\u7597\u6548\uff0c\u4e3a\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u66f4\u597d\u7684\u4e34\u5e8a\u76ca\u5904\u548c\u751f\u6d3b\u8d28\u91cf\u7684\u5e0c\u671b\uff0c\u8fd9\u4e9b\u60a3\u8005\u96be\u4ee5\u7528\u5f53\u524d\u7684\u6cbb\u7597\u65b9\u6cd5\u6cbb\u7597\u3002<\/span><\/p>\n

\u6eb6\u7624\u75c5\u6bd2Reolysin\u00ae\u83b7\u5f97\u4e86FDA \u6cbb\u7597\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u5feb\u901f\u901a\u9053\u8d44\u683c\u8ba4\u8bc1\uff0c\u7528\u4e8e\u6cbb\u7597\u5375\u5de2\u764c\u3001\u80f0\u817a\u764c\u3001\u8f93\u5375\u7ba1\u7624\u548c\u6076\u6027\u80f6\u8d28\u7624\u3002<\/span><\/p>\n

\u56fe26\uff1aReolysin <\/span>\u4fc3\u8fdb\u6297\u764c\u514d\u75ab\u53cd\u5e94<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a Oncolytics Biotech \u5b98\u7f51\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/p>\n

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5.\u4e2d\u56fd\u6eb6\u7624\u75c5\u6bd2\u524d\u666f\u5149\u660e<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n

2005 \u5e74\u5b89\u67ef\u745e\u7684\u83b7\u6279\u6781\u5927\u7684\u52a0\u901f\u4e86\u6211\u56fd\u6eb6\u7624\u75c5\u6bd2\u7684\u7814\u7a76\u30022005 \u5e74\u540e\uff0c\u6211\u56fd\u6eb6\u7624\u75c5\u6bd2\u7684\u76f8\u5173\u7814\u7a76\u62a5\u9053\u5728\u5168\u7403\u6eb6\u7624\u75c5\u6bd2\u62a5\u9053\u4e2d\u7684\u5360\u6bd4\u8fc5\u901f\u589e\u52a0\uff0c\u57282012 \u5e74\u8fbe\u5230\u5cf0\u503c\u30022005 \u5e74\u524d\uff0c\u6211\u56fd\u6eb6\u7624\u75c5\u6bd2\u5728\u7814\u54c1\u79cd\u4e3b\u8981\u4e3a\u817a\u75c5\u6bd2\uff08Adv\uff0c66%\uff09\u548c\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2\uff08HSV\uff0c10%\uff09\uff0c\u4e4b\u540e\u968f\u7740\u7814\u7a76\u7684\u6df1\u5165\uff0c\u53d1\u73b0\u7684\u53ef\u7528\u75c5\u6bd2\u54c1\u79cd\u9010\u6e10\u4e30\u5bcc\u30022016 \u5e74\uff0c\u6211\u56fd\u6700\u4e3b\u8981\u7684\u56db\u79cd\u5728\u7814\u6eb6\u7624\u75c5\u6bd2\u54c1\u79cd\u4e3b\u8981\u662f\u91cd\u7ec4\u817a\u75c5\u6bd2\uff0840.5%\uff09\uff0c\u91cd\u7ec4\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2\uff0818.9%\uff09\uff0c\u65b0\u57ce\u75ab\u75c5\u6bd2\uff08NDV 10.8%\uff09\u548c\u7532\u75c5\u6bd2\u5c5eM1\uff08alphavirus M1,10.8%\uff09\u3002<\/span><\/p>\n

\u56fe27\uff1a\u6211\u56fd\u6eb6\u7624\u75c5\u6bd2\u76f8\u5173\u62a5\u9053\u5360\u5168\u7403\u6eb6\u7624\u76f8\u5173\u62a5\u9053\u6bd4\u4f8b\u53d8\u5316     <\/span><\/p>\n

\u56fe28\uff1a\u6211\u56fd\u76ee\u524d\u5728\u7814\u6eb6\u7624\u75c5\u6bd2\u79cd\u7c7b<\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1a<\/span>HUMAN GENE THERAPY<\/span>\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/span><\/p>\n

\u76ee\u524d\uff0c\u6211\u56fd\u5728\u7814\u6eb6\u7624\u75c5\u6bd2\u8d85\u8fc7200 \u79cd\uff0c\u8fd110 \u4e2a\u516c\u5f00\u7684\u3001\u56fd\u5185\u516c\u53f8\u81ea\u4e3b\u7814\u53d1\u7684\u6eb6\u7624\u75c5\u6bd2\u6cbb\u7597\u764c\u75c7\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u3002<\/span><\/p>\n

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\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/span><\/p>\n

\u6570\u636e\u6765\u6e90\uff1aHUMAN GENE THERAPY\uff0c\u516c\u5f00\u8d44\u6599\uff0c\u897f\u5357\u8bc1\u5238\u6574\u7406<\/span><\/p>\n

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\u672a\u6765\u5341\u5e74\u5c06\u662f\u6211\u56fd\u521b\u65b0\u836f\u9ad8\u901f\u53d1\u5c55\u7684\u9636\u6bb5\uff0c\u5c3d\u7ba1\u4e2d\u56fd\u7684\u6eb6\u7624\u75c5\u6bd2\u76ee\u524d\u8fdb\u5c55\u8f83\u4e3a\u7f13\u6162\uff0c\u4f46\uff1a\u81ea2005\u5e74\u6211\u56fd\u6279\u51c6\u7b2c\u4e00\u4e2a\u6eb6\u7624\u75c5\u6bd2\u4ea7\u54c1\u5b89\u67ef\u745e\u4ee5\u6765\uff0c\u6211\u56fd\u6eb6\u7624\u75c5\u6bd2\u7684\u7814\u7a76\u70ed\u60c5\u4e0d\u51cf\u3002\u76ee\u524d\u5df2\u6709\u8d85200\u79cd\u5728\u7814\u7684\u6eb6\u7624\u75c5\u6bd2\uff0c\u5176\u4e2d\u8fd110\u4e2a\u81ea\u4e3b\u7814\u53d1\u7684\u6eb6\u7624\u75c5\u6bd2\u4ea7\u54c1\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\uff0c\u76f8\u4fe1\u968f\u8fd9\u79d1\u6280\u7684\u4e0d\u65ad\u8fdb\u6b65\uff0c\u79d1\u7814\u4eba\u5458\u961f\u4f0d\u7684\u4e0d\u65ad\u58ee\u5927\uff0c\u4e0d\u4e45\u7684\u5c06\u6765\u5c06\u8d76\u8d85\u56fd\u9645\u5236\u836f\u884c\u4e1a\u7684\u811a\u6b65\uff0c\u4e3a\u66f4\u591a\u56fd\u4eba\u7684\u75be\u75c5\u6cbb\u7597\u5e26\u6765\u798f\u97f3\u3002<\/span><\/p>\n

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<\/p>\n

\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/span><\/strong><\/span><\/p>\n

\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/p>\n

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\u672c\u516c\u4f17\u53f7\u6240\u6709\u8f6c\u8f7d\u6587\u7ae0\u7cfb\u51fa\u4e8e\u4f20\u9012\u66f4\u591a\u4fe1\u606f\u4e4b\u76ee\u7684\uff0c\u4e14\u660e\u786e\u6ce8\u660e\u6765\u6e90\u548c\u4f5c\u8005\uff0c\u4e0d\u5e0c\u671b\u88ab\u8f6c\u8f7d\u7684\u5a92\u4f53\u6216\u4e2a\u4eba\u53ef\u4e0e\u6211\u4eec\u8054\u7cfb(cbplib@163.com)\uff0c\u6211<\/span><\/span>\u4eec\u5c06\u7acb\u5373\u8fdb\u884c\u5220\u9664\u5904\u7406\u3002\u6240\u6709\u6587\u7ae0\u4ec5\u4ee3\u8868\u4f5c\u8005\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u672c\u7ad9\u7acb\u573a\u3002<\/span>
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\"\u6536\u85cf|\u6eb6\u7624\u75c5\u6bd2\u56fd\u5185\u5916\u8fdb\u5c55\"<\/strong><\/p>\n<\/section>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u751f\u7269\u5236\u54c1\u5708 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u76ee\u524d\u5df2\u6210\u4e3a\u6297\u80bf\u7624\u836f\u7269\u5e02\u573a\u7684\u4e2d\u575a\u529b\u91cf\uff0c\u5168\u7403\u5e02\u573a\u89c4\u6a21\u9884\u8ba1\u5c06\u4f1a\u4ece2016 \u5e74\u7684430&nbsp […]<\/p>\n","protected":false},"author":1,"featured_media":18966,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/18965"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=18965"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/18965\/revisions"}],"predecessor-version":[{"id":19003,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/18965\/revisions\/19003"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/18966"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=18965"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=18965"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=18965"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}