{"id":19929,"date":"2018-07-21T01:00:00","date_gmt":"2018-08-08T01:15:34","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/08\/%e9%9d%b6%e5%90%91%e6%b2%bb%e7%96%97%e7%99%bd%e8%a1%80%e7%97%85%e7%9a%84%e9%a6%96%e6%ac%beidh1%e6%8a%91%e5%88%b6%e5%89%82%e9%a6%96%e6%ac%a1%e8%8e%b7%e6%89%b9\/"},"modified":"2018-08-08T09:15:36","modified_gmt":"2018-08-08T01:15:36","slug":"%e9%9d%b6%e5%90%91%e6%b2%bb%e7%96%97%e7%99%bd%e8%a1%80%e7%97%85%e7%9a%84%e9%a6%96%e6%ac%beidh1%e6%8a%91%e5%88%b6%e5%89%82%e9%a6%96%e6%ac%a1%e8%8e%b7%e6%89%b9","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/19929\/","title":{"rendered":"\u9776\u5411\u6cbb\u7597\u767d\u8840\u75c5\u7684\u9996\u6b3eIDH1\u6291\u5236\u5242\u9996\u6b21\u83b7\u6279"},"content":{"rendered":"
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FDA\u4eca\u5929\u6279\u51c6\u4e86Agios\u5236\u836f\u516c\u53f8\u7684Tibsovo\uff08ivosidenib\uff09<\/span>\u7684\u7247\u5242<\/span>\uff0c<\/span>\u7528\u4e8e\u6cbb\u7597\u60a3\u6709\u7279\u5b9a\u57fa\u56e0\u7a81\u53d8\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6025\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08AML\uff09\u7684\u6210\u5e74\u60a3\u8005\u3002<\/span>\u8fd9\u662fIDH1\u6291\u5236\u5242\u91cc\u7b2c\u4e00\u4e2a\u88ab\u6279\u51c6\u7684\u836f\u7269<\/span>\uff0c\u5e76\u4e14\u8fd8\u6279\u51c6\u4e86\u7528\u4e8eAML\u60a3\u8005IDH1\u57fa\u56e0\u7684\u7279\u5b9a\u7a81\u53d8\u7684\u68c0\u6d4b\u65b9\u6cd5\u3002Tibsovo\u83b7\u5f97\u4e86\u5feb\u901f\u901a\u9053\u8d44\u683c\u3001\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\u3001\u4ee5\u53ca\u5b64\u513f\u836f\u8d44\u683c\u3002<\/span><\/p>\n<\/p>\n

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TIBSOVO\u00ae\uff08ivosidenib\uff09\uff08\u56fe\u7247\u6765\u6e90\uff1aAgios Pharmaceuticals\u7f51\u7ad9\uff09<\/p>\n

 <\/p>\n

AML\u662f\u4e00\u79cd\u5feb\u901f\u53d1\u5c55\u7684\u764c\u75c7\uff0c\u5b83\u5728\u9aa8\u9ad3\u4e2d\u5f62\u6210\uff0c\u5e76\u4f7f\u8840\u6db2\u548c\u9aa8\u9ad3\u4e2d\u5f02\u5e38\u767d\u7ec6\u80de\u7684\u6570\u91cf\u589e\u52a0\u3002<\/span>\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u7684\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\u9884\u4f30\uff0c\u4eca\u5e74\u5c06\u6709\u5927\u7ea619,520\u4eba\u88ab\u8bca\u65ad\u4e3aAML\uff0c\u5927\u7ea610,670\u540dAML\u60a3\u8005\u5c06\u57282018\u5e74\u6b7b\u4e8e\u8be5\u75be\u75c5\u3002<\/p>\n

 <\/p>\n

Tibsovo\u662f\u4e00\u79cd\u5f02\u67e0\u6aac\u9178\u8131\u6c22\u9176-1\u6291\u5236\u5242\uff0c<\/span>\u901a\u8fc7\u51cf\u5c11\u5f02\u5e38\u4ea7\u751f\u76842-\u7f9f\u57fa\u620a\u4e8c\u9178\u7684\u4ee3\u8c22\u4ea7\u7269\u800c\u4f7f\u6076\u6027\u7ec6\u80de\u5206\u5316\u3002 \u5982\u679cIDH1\u7a81\u53d8\u53ef\u4ee5\u5728\u8840\u6db2\u6216\u9aa8\u9ad3\u6837\u672c\u4e2d\u68c0\u6d4b\u5230\uff0c\u5219\u60a3\u8005\u624d\u53ef\u80fd\u6709\u8d44\u683c\u63a5\u53d7Tibsovo\u6cbb\u7597\u3002\u4eca\u5929\uff0cFDA\u8fd8\u6279\u51c6\u4e86\u4e00\u6240\u53ef\u7528\u4e8e\u68c0\u6d4b\u8fd9\u79cd\u7a81\u53d8\u7684\u8bca\u6240\uff08RealTime IDH1 Assay\uff09\u3002<\/p>\n

 <\/p>\n

Tibsovo\u7684\u7597\u6548\u7814\u7a76\u662f\u5728174\u4f8b\u60a3\u6709IDH1\u7a81\u53d8\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027AML\u7684\u6210\u4eba\u60a3\u8005\u4e2d\u8fdb\u884c\u4e86\u5355\u81c2\u8bd5\u9a8c<\/span>\u3002\u8be5\u8bd5\u9a8c\u4ee5\u7ecf\u8fc7Tibsovo\u6cbb\u7597\u540e\u5b8c\u5168\u6062\u590d\u7684\u60a3\u8005\u767e\u5206\u6bd4\uff08\u5b8c\u5168\u7f13\u89e3\u6216CR\uff09\uff0c\u4ee5\u53ca\u6cbb\u7597\u540e\u90e8\u5206\u6062\u590d\u7684\u60a3\u8005\uff08\u90e8\u5206\u8840\u6db2\u5b66\u5b8c\u5168\u7f13\u89e3\u6062\u590d\u6216CRh\uff09\u7684\u767e\u5206\u6bd4\u8fdb\u884c\u7edf\u8ba1\u3002\u57288.3\u4e2a\u6708\u7684\u4e2d\u4f4d\u968f\u8bbf\u4e2d\uff0c32.8%\u7684\u60a3\u8005\u51fa\u73b0CR \u6216CRh<\/span>\uff0c\u4e2d\u4f4d\u6570\u6301\u7eed8.2\u4e2a\u6708\u3002\u5728\u7814\u7a76\u5f00\u59cb\u65f6\u9700\u8981\u8f93\u6ce8AML\u8840\u6db2\u6216\u8840\u5c0f\u677f\u7684110\u540d\u60a3\u8005\u4e2d\uff0c37\uff05\u7684\u60a3\u8005\u5728\u4f7f\u7528Tibsovo\u6cbb\u7597\u540e\u81f3\u5c1156\u5929\u5185\u90fd\u4e0d\u9700\u8981\u518d\u8fdb\u884c\u8f93\u8840\u3002<\/p>\n

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Tibsovo\u7684\u5e38\u89c1\u526f\u4f5c\u7528<\/span>\u5305\u62ec\u75b2\u52b3\u3001\u767d\u7ec6\u80de\u589e\u52a0\u3001\u5173\u8282\u75bc\u75db\u3001\u8179\u6cfb\u3001\u547c\u5438\u77ed\u4fc3\u3001\u624b\u81c2\u6216\u817f\u90e8\u80bf\u80c0\u3001\u53e3\u8154\u6216\u5589\u5499\u6076\u5fc3\u3001\u75bc\u75db\u6216\u75bc\u75db\u3001\u5fc3\u5f8b\u4e0d\u9f50\u3001\u76ae\u75b9\u3001\u53d1\u70e7\u3001\u54b3\u55fd\u548c\u4fbf\u79d8\u3002\u54fa\u4e73\u671f\u7684\u5987\u5973\u4e0d\u5e94\u670d\u7528Tibsovo\uff0c<\/span>\u56e0\u4e3a\u5b83\u53ef\u80fd\u5bf9\u65b0\u751f\u513f\u9020\u6210\u4f24\u5bb3\u3002<\/p>\n

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\u5176\u4ed6\u4e25\u91cd\u7684\u8b66\u544a\u5305\u62ecQT\u5ef6\u957f\uff0c\u8fd9\u53ef\u80fd\u5371\u53ca\u751f\u547d\u3002\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\uff0c\u5e94\u901a\u8fc7\u5fc3\u7535\u56fe\u6765\u68c0\u6d4b\u5fc3\u810f\u7684\u7535\u6d3b\u52a8\u3002\u683c\u6797-\u5df4\u5229\u7efc\u5408\u5f81\u5df2\u53d1\u751f\u5728\u63a5\u53d7Tibsovo\u6cbb\u7597\u7684\u60a3\u8005\u8eab\u4e0a\uff0c<\/span>\u5b83\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff0c\u8eab\u4f53\u7684\u514d\u75ab\u7cfb\u7edf\u9519\u8bef\u5730\u653b\u51fb\u4e86\u5b83\u5468\u56f4\u795e\u7ecf\u7cfb\u7edf\u7684\u4e00\u90e8\u5206\uff0c\u56e0\u6b64\u60a3\u8005\u5e94\u8be5\u88ab\u76d1\u6d4b\u795e\u7ecf\u7cfb\u7edf\u7684\u95ee\u9898\u3002<\/p>\n

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FDA\u80bf\u7624\u5b66\u4e2d\u5fc3\u4e3b\u4efb\uff0c\u836f\u7269\u8bc4\u4f30\u548c\u7814\u7a76\u4e2d\u5fc3\u8840\u6db2\u5b66\u548c\u80bf\u7624\u5b66\u4ea7\u54c1\u529e\u516c\u5ba4\u4ee3\u7406\u4e3b\u4efbRichard Pazdur\u535a\u58eb\u8bf4\u201cTibsovo\u662f\u4e00\u79cd\u9776\u5411\u6cbb\u7597\uff0c\u53ef\u4ee5\u6ee1\u8db3\u60a3\u6709IDH1\u7a81\u53d8\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027AML\u60a3\u8005\u201d\u3002<\/span>\u201cTibsovo\u53ef\u4ee5\u4f7f\u4e00\u4e9b\u60a3\u8005\u7684\u75c7\u72b6\u5b8c\u5168\u5f97\u5230\u7f13\u89e3\uff0c\u5e76\u53ef\u4ee5\u51cf\u5c11\u60a3\u8005\u5bf9\u7ea2\u7ec6\u80de\u548c\u8840\u5c0f\u677f\u8f93\u6ce8\u7684\u9700\u6c42\u3002\u201d<\/p>\n

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\u603b\u800c\u8a00\u4e4b\uff0c\u8fd9\u4e00\u6210\u679c\u7684\u83b7\u5f97\u662f\u5bf9\u767d\u8840\u75c5\u60a3\u8005\u6765\u8bf4\u662f\u4e00\u4e2a\u798f\u97f3\uff0c\u6211\u4eec\u671f\u5f85FDA\u5e26\u7ed9\u6211\u4eec\u66f4\u591a\u7684\u597d\u6d88\u606f\u3002<\/span><\/p>\n


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\u53c2\u8003\u6587\u732e\uff1a<\/span><\/span><\/p>\n

FDA approves first targeted treatment for patients with relapsed or refractory acute myeloid leukemia who have a certain genetic mutation<\/h1>\n

 <\/span> <\/span><\/p>\n

\u6392\u7248\uff1aSUNRISE<\/span>
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\u5e7f\u800c\u544a\u4e4b<\/section>\n<\/section>\n<\/section>\n
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\u6ee1\u8db3IND\/NDA\u4e2d\u7f8e\u53cc\u62a5\u7684\u53e3\u670d\u65b0\u836f\u5236\u5242\u7814\u53d1<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u9776\u5411\u6cbb\u7597\u767d\u8840\u75c5\u7684\u9996\u6b3eIDH1\u6291\u5236\u5242\u9996\u6b21\u83b7\u6279\"<\/p>\n

\u836f\u4e8b\u7eb5\u6a2a\u662f\u4e00\u4e2a\u5f00\u653e\uff0c\u7531\u81ea\u613f\u8005\u7ec4\u6210\u7684\u56e2\u4f53\uff0c\u73b0\u6709\u6210\u545838\u540d\uff0c\u5206\u522b\u4e3aVoyager88\uff08\u9b4f\u5229\u519b\uff09\uff0c\u96f7\u8bfa\u5c9b\uff0c\u4e09\u5206\u8bdd\uff0cHerman\uff0c\u6885\u5e0c\uff0c\u6587\u7af9\uff0cduke\uff0cyhqqqqq\uff0c\u5360\u5c0f\u5175\uff0c\u98ce\u4e00\u6837\u7684\u5c4e\u58f3\u90ce\uff0c\u9526\u5fc3\u7ee3\u53e3\uff0cflydp511\uff0c\u5de7\u5de7\uff0c\u4e91\u6c34\u9053\u4eba\uff0c\u9621\u4e0a\u964c\u964c\uff0c\u591a\u5df4\u80fa\uff0c\u745c\u513f\uff0cKailyn\uff0cSmall fish\uff0c\u5b50\u708e\uff0c\u514b\u683c\u83ab\uff0cVicky\uff0cPandada\uff0c\u83ab\u5306\u5306\uff0cSophia \uff0c\u4f9d\u7136\u7279\u96f7\u897f\uff0c\u5076\u9635\u96e8\uff0cAimee\uff0c\u4ed6\u5c71\u4e4b\u77f3\uff0c\u5510\u5c0f\u7396\uff0c\u96f6\u4e0b274\u2103\uff0cGloria\uff0cBreathless\uff0cLuffy\uff0c\u80e1\u4e0d\u559c\uff0c Helen\uff0c\u843d\u843d\uff0cSUNRISE\u3002\u6b22\u8fce\u6709\u5fd7\u4e4b\u58eb\u52a0\u5165\u6211\u4eec\u56e2\u961f\u3002\u6295\u7a3f\u3001\u5408\u4f5c\u3001\u52a0\u4e13\u4e1a\u7fa4\u8bf7\u52a0\u5fae\u4fe1442015666\uff0c\u836f\u4e8b\u7eb5\u6a2a\u4e8c\u5343\u4ebaQQ\u7fa422711855\u3002<\/span><\/p>\n

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