{"id":19976,"date":"2018-07-20T01:00:00","date_gmt":"2018-08-08T01:15:53","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/08\/%e9%80%9f%e9%80%92-fda%e7%aa%81%e7%a0%b4%e6%80%a7%e6%96%b0%e6%94%bf%e8%af%95%e7%82%b9%e9%a1%b9%e7%9b%ae%e9%a6%96%e4%b8%aa%e5%93%81%e7%a7%8d%e8%8e%b7%e6%89%b9\/"},"modified":"2018-08-08T09:15:55","modified_gmt":"2018-08-08T01:15:55","slug":"%e9%80%9f%e9%80%92-fda%e7%aa%81%e7%a0%b4%e6%80%a7%e6%96%b0%e6%94%bf%e8%af%95%e7%82%b9%e9%a1%b9%e7%9b%ae%e9%a6%96%e4%b8%aa%e5%93%81%e7%a7%8d%e8%8e%b7%e6%89%b9","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/19976\/","title":{"rendered":"\u901f\u9012 | FDA\u7a81\u7834\u6027\u65b0\u653f\u8bd5\u70b9\u9879\u76ee\u9996\u4e2a\u54c1\u79cd\u83b7\u6279"},"content":{"rendered":"
\n

\u4eca\u5929FDA\u6279\u51c6\u4e86\u8bfa\u534e\u5236\u836f\u516c\u53f8\u7684Kisqali \uff08ribociclib\uff09\u4e0e\u82b3\u9999\u9176\u6291\u5236\u5242\u8054\u5408\u4f5c\u4e3a\u521d\u59cb\u5185\u5206\u6ccc\u7597\u6cd5\uff0c<\/span>\u8be5\u8054\u5408\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u7edd\u7ecf\u671f\u524d\/\u7edd\u7ecf\u671f\u6216\u7edd\u7ecf\u540e\u60a3\u6709HR\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u7684\u5987\u5973\u548c\u60a3\u6709\u4eba\u7c7b\u8868\u76ae\u751f\u957f\u56e0\u5b502HER2\u53d7\u4f53\u9634\u6027\u7684\u5987\u5973\uff0c\u4e5f\u53ef\u4ee5\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u3002 FDA\u8fd8\u6279\u51c6Kisqali\u4e0e\u6c1f\u7ef4\u53f8\u7fa4\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u60a3\u6709HR\u9633\u6027\u3001HER2\u9634\u6027\u665a\u671f\u548c\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u7edd\u7ecf\u540e\u7684\u5987\u5973\uff0c<\/span>\u521d\u59cb\u5185\u5206\u6ccc\u7597\u6cd5\u6216\u75be\u75c5\u8fdb\u5c55\u7597\u6cd5\u90fd\u4f9d\u636e\u7684\u662f\u5185\u5206\u6ccc\u7597\u6cd5\u3002<\/span><\/p>\n


<\/p>\n

\n

\u4e73\u817a\u764c\u662f\u7f8e\u56fd\u6700\u5e38\u89c1\u7684\u764c\u75c7\u3002<\/span>\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\u4f30\u8ba1\uff0c\u4eca\u5e74\u5c06\u6709\u7ea6266,120\u540d\u5973\u6027\u88ab\u8bca\u65ad\u60a3\u6709\u4e73\u817a\u764c\uff0c40,920\u540d\u5973\u6027\u5c06\u6b7b\u4e8e\u4e73\u817a\u764c\u3002\u5927\u7ea672%\u7684\u4e73\u817a\u764c\u60a3\u8005\u60a3\u6709HR\u9633\u6027\u3001HER2\u9634\u6027\u7684\u80bf\u7624\u3002<\/p>\n


<\/p>\n

Kisqali\u4e8e2017\u5e743\u6708\u9996\u6b21\u88ab\u6279\u51c6\u7528\u4e8e\u7edd\u7ecf\u540e\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u3001\u4eba\u7c7b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53-2\u9634\u6027(HR+ \/HER2-)\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u5973\u6027\u60a3\u8005\u3002<\/span>\u4f46\u5176\u5e38\u89c1\u526f\u4f5c\u7528\u662f\u611f\u67d3\u3001\u5f02\u5e38\u767d\u7ec6\u80de\u8ba1\u6570\uff08\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff09\u3001\u8840\u6db2\u4e2d\u767d\u7ec6\u80de\u51cf\u5c11\u3001\u5934\u75db\u3001\u54b3\u55fd\u3001\u6076\u5fc3\u3001\u75b2\u52b3\u3001\u8179\u6cfb\u3001\u5455\u5410\u3001\u4fbf\u79d8\u3001\u8131\u53d1\u548c\u76ae\u75b9\u3002\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9879\u5305\u62ec\uff1a\u5fc3\u810f\u95ee\u9898\u7684\u98ce\u9669\uff0c\u5373QT\u95f4\u671f\u5ef6\u957f\u53ef\u80fd\u5bfc\u81f4\u5fc3\u7387\u5f02\u5e38\u3001\u4e25\u91cd\u7684\u809d\u810f\u95ee\u9898\u3001\u4e25\u91cd\u611f\u67d3\u7684\u4f4e\u767d\u7ec6\u80de\u8ba1\u6570\u4ee5\u53ca\u53ef\u5f15\u8d77\u80ce\u513f\u4f24\u5bb3\uff0c\u751a\u81f3\u53ef\u80fd\u5bfc\u81f4\u6b7b\u4ea1\u3002\u4e3a\u6b64\uff0c\u901a\u8fc7\u8054\u5408\u7528\u836f\u589e\u5f3a\u4e34\u5e8a\u7597\u6548\u4ee5\u53ca\u964d\u4f4e\u526f\u4f5c\u7528\u3002<\/p>\n

 <\/span><\/strong><\/p>\n

\u8054\u5408\u7528\u836f\u7684\u4e34\u5e8a\u7597\u6548<\/span><\/strong><\/p>\n


<\/span><\/strong><\/p>\n

\u5728495\u540d\u5fd7\u613f\u8005\u4e2d\uff0c\u63a5\u53d7Kisqali\u548c\u82b3\u9999\u9176\u6291\u5236\u5242\uff08AI\uff09\u8054\u5408\u7528\u836f\u4e0e\u5b89\u6170\u5242\u548cAI\u8054\u5408\u7528\u836f\u7684\u8bd5\u9a8c\u7ed3\u679c\u76f8\u6bd4\uff0cKisqali\u4e0eAI\u8054\u5408\u6cbb\u7597\u7edd\u7ecf\u524d\u6216\u56f4\u7edd\u7ecf\u671f\u5987\u5973\u7684\u7597\u6548\u660e\u663e\u4f18\u4e8e\u5b89\u6170\u5242\u7ec4\u3002\u672c\u7814\u7a76\u4e2d\u6240\u6709\u7edd\u7ecf\u524d\u6216\u56f4\u7edd\u7ecf\u671f\u60a3\u8005\u5747\u63a5\u53d7\u4e86\u918b\u9178\u6208\u820d\u745e\u6797\u7684\u5375\u5de2\u6291\u5236\u3002\u8bd5\u9a8c\u6d4b\u91cf\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u662f\u4ece\u968f\u673a\u5316\u5f00\u59cb\u5230\u80bf\u7624\u53d1\u751f\uff08\u4efb\u4f55\u65b9\u9762\uff09\u8fdb\u5c55\u6216\uff08\u56e0\u4efb\u4f55\u539f\u56e0\uff09\u6b7b\u4ea1\u4e4b\u95f4\u7684\u65f6\u95f4\u3002\u76f8\u6bd4\u4e8e\u63a5\u53d7\u5b89\u6170\u5242\u52a0AI\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u768413.8\u4e2a\u6708\uff0c\u670d\u7528Kisqali\u52a0AI\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u768427.5\u4e2a\u6708\u66f4\u957f\u3002<\/span><\/p>\n


<\/p>\n

\u5728726\u540d\u63a5\u53d7Kisqali\u548c\u6c1f\u7ef4\u53f8\u7fa4\u8054\u5408\u7528\u836f\u6216\u5b89\u6170\u5242\u548c\u6c1f\u7ef4\u53f8\u7fa4\u7684\u60a3\u8005\u7684\u8bd5\u9a8c\u4e2d\uff0cKisqali\u8054\u5408\u6c1f\u7ef4\u53f8\u7fa4\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u7597\u6548\u5728\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u5230\u8bc1\u5b9e\u3002\u4e0e\u670d\u7528\u5b89\u6170\u5242\u52a0\u6c1f\u7ef4\u53f8\u7fa4\u7684\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u768412.8\u4e2a\u6708\u76f8\u6bd4\uff0c\u670d\u7528Kisqali\u52a0\u6c1f\u7ef4\u53f8\u7fa420.5\u4e2a\u6708\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u66f4\u957f\u3002<\/span><\/p>\n

 <\/p>\n

FDA\u7a81\u7834\u6027\u65b0\u653f<\/span><\/strong><\/span><\/strong><\/p>\n


<\/p>\n

FDA\u5728\u4eca\u5e74\u65e9\u4e9b\u65f6\u5019\u5ba3\u5e03\u4e86\u4e24\u4e2a\u65b0\u8bd5\u70b9\u9879\u76ee\uff0c\u800c\u8be5\u8054\u5408\u7597\u6cd5\u4f5c\u4e3a\u8fd9\u4e24\u4e2a\u65b0\u8bd5\u70b9\u9879\u76ee\u7684\u4e00\u90e8\u5206\u662f\u9996\u4e2a\u88ab\u6279\u51c6\u7684\u3002\u8fd9\u4e24\u4e2a\u65b0\u8bd5\u70b9\u9879\u76ee\u65e8\u5728\u4f7f\u764c\u75c7\u836f\u7269\u7684\u7814\u53d1\u548c\u5ba1\u8bc4\u66f4\u52a0\u6709\u6548\uff0c\u540c\u65f6\u6539\u8fdbFDA\u8bc4\u4f30\u7597\u6548\u548c\u5b89\u5168\u6027\u7684\u4e25\u683c\u6807\u51c6\uff0c<\/span>\u901a\u8fc7\u8fd9\u79cd\u5b9e\u65f6\u5ba1\u67e5\uff0cFDA\u80fd\u591f\u5728\u8bd5\u9a8c\u7ed3\u679c\u51fa\u73b0\u540e\u7acb\u5373\u5f00\u59cb\u8bc4\u4f30\u4e34\u5e8a\u6570\u636e\uff0c\u4e3a\u5176\u4ee5\u540e\u7684\u6279\u51c6\u505a\u597d\u51c6\u5907\u3002<\/p>\n


<\/p>\n

\u8fd9\u4e24\u4e2a\u8bd5\u70b9\u9879\u76ee<\/span>\u4e3a\u5b9e\u65f6\u764c\u75c7\u5ba1\u8bc4\uff08Real-Time Oncology Review\uff09\u548c\u65b0\u7684\u6a21\u677f\u5316\u8bc4\u4f30\u63f4\u52a9\uff08Assessment Aid\uff09<\/span>\uff0c\u76ee\u524d\uff0c\u8fd9\u4e24\u4e2a\u8bd5\u70b9\u9879\u76ee\u4ec5\u7528\u4e8e\u5df2\u7ecf\u6279\u51c6\u7684\u6297\u764c\u836f\u7269\u7684\u8865\u5145\u7533\u8bf7\uff0c\u4e4b\u540e\u4f1a\u6269\u5c55\u5230\u539f\u6599\u836f\u548c\u751f\u7269\u5236\u5242\u3002Real-Time Oncology Review\u5141\u8bb8FDA\u5728\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u53ef\u7528\u4e14\u6570\u636e\u5e93\u88ab\u9501\u5b9a\u4e4b\u540e\uff0c\u800c\u6240\u6709\u4fe1\u606f\u6b63\u5f0f\u63d0\u4ea4\u4e4b\u524d\u5ba1\u67e5\u5176\u65e9\u671f\u7684\u5927\u90e8\u5206\u6570\u636e\uff0c\u8fd9\u4f7f\u5f97FDA\u53ef\u4ee5\u66f4\u65e9\u5730\u5f00\u59cb\u5bf9\u6570\u636e\u8fdb\u884c\u5206\u6790\uff0c\u5e76\u5411\u5382\u5bb6\u63d0\u4f9b\u53cd\u9988\uff0c<\/span>\u544a\u8bc9\u4ed6\u4eec\u5982\u4f55\u6700\u6709\u6548\u5730\u5206\u6790\u6570\u636e\u4ee5\u56de\u7b54\u5173\u952e\u76d1\u7ba1\u95ee\u9898\u3002\u8be5\u8bd5\u70b9\u4fa7\u91cd\u4e8e\u63d0\u524d\u63d0\u4ea4\u4e0e\u4ea7\u54c1\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u8bc4\u4f30\u6700\u76f8\u5173\u7684\u6570\u636e\uff0c\u4ee5\u4fbfFDA\u5728\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u6b63\u5f0f\u63d0\u4ea4\u524d\u5373\u5f00\u59cb\u5ba1\u8bc4\u3002<\/p>\n


<\/p>\n

Assessment Aid\u65b9\u4fbf\u7533\u8bf7\u516c\u53f8\u7528\u7ed3\u6784\u5316\u7684\u683c\u5f0f\u8fdb\u884c\u63d0\u4ea4\uff0c\u52a0\u901fFDA\u5bf9\u7533\u8bf7\u7684\u5ba1\u67e5\uff0c<\/span>\u901a\u8fc7\u4f7f\u7528\u7ed3\u6784\u5316\u6a21\u677f\uff0cFDA\u80fd\u591f\u5c06\u5176\u8bc4\u4f30\u5199\u5165\u5382\u5546\u63d0\u4ea4\u7684\u540c\u4e00\u6587\u4ef6\u4e2d\uff0c\u5e76\u4e14\u5141\u8bb8\u8fd9\u79cd\u5e26\u6709FDA\u5ba1\u67e5\u6ce8\u91ca\u7684\u8bae\u6848\u4f5c\u4e3a\u4e00\u4efd\u6587\u4ef6\u3002\u8fd9\u79cd\u7ed3\u6784\u5316\u7684\u683c\u5f0f\u4e3a\u5ba1\u67e5\u6570\u636e\u548c\u8bf4\u660eFDA\u7684\u5206\u6790\u63d0\u4f9b\u4e86\u66f4\u7b80\u5316\u7684\u65b9\u6cd5\u3002\u5b83\u4f7f\u836f\u7269\u5ba1\u67e5\u5458\u66f4\u52a0\u5173\u6ce8\u4e3b\u8981\u7684\u5229\u76ca\u98ce\u9669\u548c\u6807\u6ce8\u95ee\u9898\u3002<\/p>\n


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 \u201c\u901a\u8fc7\u8fd9\u9879\u6279\u51c6\uff0c\u6211\u4eec\u5df2\u7ecf\u770b\u5230\u4e86\u65b0\u8bd5\u70b9\u9879\u76ee\u7684\u4e00\u4e9b\u597d\u5904\uff0c\u5b83\u53ef\u4ee5\u63d0\u9ad8\u76d1\u7ba1\u6548\u7387\uff0c<\/span>\u540c\u65f6\u52a0\u5f3a\u6211\u4eec\u5bf9\u6570\u636e\u7684\u8bc4\u4f30\u8fc7\u7a0b\u3002<\/span>\u8fd9\u8868\u660e\uff0c\u901a\u8fc7\u4e00\u4e9b\u5408\u7406\u7684\u653f\u7b56\u9014\u5f84\uff0c\u6211\u4eec\u53ef\u4ee5\u5728\u63d0\u9ad8\u6548\u7387\u7684\u540c\u65f6\u63d0\u9ad8\u6d41\u7a0b\u7684\u4e25\u8c28\u6027\u3002\u8fd9\u4e9b\u65b0\u8ba1\u5212\u65e8\u5728\u51cf\u5c11\u5ba1\u67e5\u8fc7\u7a0b\u4e2d\u7684\u65f6\u95f4\u548c\u6210\u672c\u95ee\u9898\uff0c\u5305\u62ecFDA\u7684\u4eba\u5458\u914d\u7f6e\u8d1f\u62c5\u3002\u4f8b\u5982\uff0c\u901a\u8fc7\u5728\u6b63\u5f0f\u63d0\u4ea4\u7ed9FDA\u4e4b\u524d\u66f4\u65e9\u5730\u5206\u6790\u6570\u636e\uff0c\u4ee5\u53ca\u5728\u7ed3\u6784\u5316\u6a21\u677f\u4e2d\u8bc4\u4f30\u63d0\u4ea4\u7684\u6570\u636e\uff0c<\/span>\u6211\u4eec\u53ef\u4ee5\u66f4\u5bb9\u6613\u5730\u66f4\u65e9\u8bc6\u522b\u5728\u7533\u8bf7\u4e2d\u7f3a\u5c11\u7684\u53ef\u80fd\u5ef6\u8fdf\u5ba1\u8bc4\u7684\u5173\u952e\u5206\u6790\u6216\u4fe1\u606f\u3002<\/p>\n


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FDA\u5c40\u957fScott Gottlieb\u535a\u58eb\u8868\u793a\uff1a\u201c\u7ecf\u8fc7\u4eca\u5929\u7684\u6279\u51c6\uff0cFDA\u4f7f\u7528\u8fd9\u4e9b\u65b0\u65b9\u6cd5\u4f7f\u5ba1\u6838\u5c0f\u7ec4\u5728\u5b9e\u9645\u63d0\u4ea4\u7533\u8bf7\u4e4b\u524d\u5f00\u59cb\u5206\u6790\u6570\u636e\uff0c\u5e76\u5e2e\u52a9\u6307\u5bfc\u516c\u53f8\u5bf9\u9876\u7ebf\u6570\u636e\u7684\u5206\u6790\uff0c\u4ee5\u68b3\u7406\u51fa\u6700\u76f8\u5173\u7684\u4fe1\u606f\u3002\u8fd9\u4f7f\u6211\u4eec\u57286\u670828\u65e5\u63d0\u4ea4\u540e\u4e0d\u5230\u4e00\u4e2a\u6708\u5c31\u6279\u51c6\u4e86\u8be5\u7597\u6cd5\uff0c\u6bd4\u76ee\u6807\u65e5\u671f\u63d0\u524d\u4e86\u51e0\u4e2a\u6708\u3002\u201d\u8fd9\u4e9b\u65b0\u6d41\u7a0b\u5bf9\u60a3\u8005\u6709\u76ca\uff0c\u5bf9\u533b\u7597\u4fdd\u5065\u63d0\u4f9b\u8005\u6709\u76ca\uff0c\u5bf9\u4ea7\u54c1\u5f00\u53d1\u4eba\u5458\u6709\u76ca\uff0c\u5bf9FDA\u4e5f\u6709\u597d\u5904\uff0c\u6211\u4eec\u7684\u5458\u5de5\u53ef\u4ee5\u6709\u66f4\u591a\u65f6\u95f4\u4e0e\u4ea7\u54c1\u5f00\u53d1\u4eba\u5458\u63a2\u8ba8\u836f\u7269\u5ba1\u67e5\u7684\u5173\u952e\u65b9\u9762\u7684\u77e5\u8bc6<\/span>\u3002 \u6211\u4eec\u53ef\u4ee5\u63d0\u9ad8\u6548\u7387\u5e76\u5de9\u56fa\u6211\u4eec\u7684\u9ec4\u91d1\u6807\u51c6\u4ee5\u4f9b\u5ba1\u67e5\u3002<\/p>\n


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FDA\u836f\u54c1\u8bc4\u4ef7\u4e0e\u7814\u7a76\u4e2d\u5fc3\u8840\u6db2\u4e0e\u80bf\u7624\u836f\u54c1\u529e\u516c\u5ba4\u4e3b\u4efbRichard Pazdur\u535a\u58eb\u79f0\uff1a\u201c\u6211\u4eec\u81f4\u529b\u4e8e\u7ee7\u7eed\u4e3a\u60a3\u8005\u5e26\u6765\u66f4\u591a\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u8fd9\u4e00\u6279\u51c6\u4e3a\u4e73\u817a\u764c\u60a3\u8005\u589e\u52a0\u4e86\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/span><\/p>\n


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\u53c2\u8003\u6587\u732e\uff1a<\/p>\n

FDA approves first cancer drug through new oncology review pilot that enables greater development efficiency.<\/p>\n


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\u5e7f\u800c\u544a\u4e4b<\/span><\/p>\n

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\u2299 \u540c\u5199\u610f\u57f9\u8bad<\/span><\/p>\n

\u5199\u610f\u8bba\u575b\u4e28\u65b0\u836f\u4e2d\u7f8e\u53cc\u62a5\u4e4b\u5236\u5242\u6eb6\u51fa\u6280\u672f\u5f00\u53d1<\/a><\/span><\/p>\n

\u5199\u610f\u8bba\u575b\u4e28\u56fd\u9645\u89c4\u8303\u4e0b\u751f\u7269\u836f\u5168\u751f\u547d\u5468\u671f\u8d28\u91cf\u7ba1\u7406<\/a><\/span><\/p>\n

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\u6ee1\u8db3IND\/NDA\u4e2d\u7f8e\u53cc\u62a5\u7684\u53e3\u670d\u65b0\u836f\u5236\u5242\u7814\u53d1<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n


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\u836f\u4e8b\u7eb5\u6a2a\u662f\u4e00\u4e2a\u5f00\u653e\uff0c\u7531\u81ea\u613f\u8005\u7ec4\u6210\u7684\u56e2\u4f53\uff0c\u73b0\u6709\u6210\u545838\u540d\uff0c\u5206\u522b\u4e3aVoyager88\uff08\u9b4f\u5229\u519b\uff09\uff0c\u96f7\u8bfa\u5c9b\uff0c\u4e09\u5206\u8bdd\uff0cHerman\uff0c\u6885\u5e0c\uff0c\u6587\u7af9\uff0cduke\uff0cyhqqqqq\uff0c\u5360\u5c0f\u5175\uff0c\u98ce\u4e00\u6837\u7684\u5c4e\u58f3\u90ce\uff0c\u9526\u5fc3\u7ee3\u53e3\uff0cflydp511\uff0c\u5de7\u5de7\uff0c\u4e91\u6c34\u9053\u4eba\uff0c\u9621\u4e0a\u964c\u964c\uff0c\u591a\u5df4\u80fa\uff0c\u745c\u513f\uff0cKailyn\uff0cSmall fish\uff0c\u5b50\u708e\uff0c\u514b\u683c\u83ab\uff0cVicky\uff0cPandada\uff0c\u83ab\u5306\u5306\uff0cSophia \uff0c\u4f9d\u7136\u7279\u96f7\u897f\uff0c\u5076\u9635\u96e8\uff0cAimee\uff0c\u4ed6\u5c71\u4e4b\u77f3\uff0c\u5510\u5c0f\u7396\uff0c\u96f6\u4e0b274\u2103\uff0cGloria\uff0cBreathless\uff0cLuffy\uff0c\u80e1\u4e0d\u559c\uff0c Helen\uff0c\u843d\u843d\uff0cSUNRISE\u3002\u6b22\u8fce\u6709\u5fd7\u4e4b\u58eb\u52a0\u5165\u6211\u4eec\u56e2\u961f\u3002\u6295\u7a3f\u3001\u5408\u4f5c\u3001\u52a0\u4e13\u4e1a\u7fa4\u8bf7\u52a0\u5fae\u4fe1442015666\uff0c\u836f\u4e8b\u7eb5\u6a2a\u4e8c\u5343\u4ebaQQ\u7fa422711855\u3002<\/span><\/p>\n


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