{"id":20000,"date":"2018-07-18T01:00:00","date_gmt":"2018-08-08T01:16:01","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/08\/%e5%88%9b%e9%80%a0%e7%ac%ac%e4%b8%80%e6%ac%be%e9%a2%84%e9%98%b2%e5%81%8f%e5%a4%b4%e7%97%9b%e8%8d%af%e7%89%a9%ef%bc%9a%e4%bb%96%e4%bb%ac%e6%98%af%e8%8d%af%e7%a5%9e\/"},"modified":"2018-08-08T09:16:03","modified_gmt":"2018-08-08T01:16:03","slug":"%e5%88%9b%e9%80%a0%e7%ac%ac%e4%b8%80%e6%ac%be%e9%a2%84%e9%98%b2%e5%81%8f%e5%a4%b4%e7%97%9b%e8%8d%af%e7%89%a9%ef%bc%9a%e4%bb%96%e4%bb%ac%e6%98%af%e8%8d%af%e7%a5%9e","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/20000\/","title":{"rendered":"\u521b\u9020\u7b2c\u4e00\u6b3e\u9884\u9632\u504f\u5934\u75db\u836f\u7269\uff1a\u4ed6\u4eec\u662f\u836f\u795e"},"content":{"rendered":"
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<\/p>\n

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\u6bcf\u4e00\u4e2a\u65b0\u836f<\/span><\/span>\u7684\u95ee\u4e16<\/span>\u90fd\u662f\u4f20\u5947<\/span><\/span>\uff0c\u95ee\u9898\u7684\u4e0d\u65ad\u51fa\u73b0\uff0c\u5230\u95ee\u9898\u7684\u76f8\u7ee7\u89e3\u51b3\uff0c\u65e0\u4e0d\u8868\u73b0\u51fa\u4e86\u79d1\u5b66\u5bb6\u548c\u7ba1\u7406\u8005\u7684\u667a\u6167\u3001\u679c\u65ad\u548c\u6267\u7740\u3002\u4ece\u5b83\u4eec\u7684\u6545\u4e8b\u4e2d\uff0c\u6216\u8bb8\u80fd\u591f\u53d1\u73b0\u548c\u9886\u609f\u51fa\u4e00\u4e9b\u5bf9\u6211\u4eec\u4eca\u540e\u5de5\u4f5c\u4e43\u81f3\u4eba\u751f\u6709\u76ca\u7684\u4e1c\u897f\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n<\/section>\n

\u300a\u683c\u5217\u536b\u8bde\u751f\u8bb0\uff1a\u96be\u4ee5\u590d\u5236\u7684\u6297\u764c\u5947\u8ff9\u300b<\/span><\/span><\/span><\/a>\uff0c<\/span><\/span>\u8bc9\u8bf4\u4e86\u683c\u5217\u536b<\/span><\/span>\uff08\u7532\u78fa\u9178\u4f0a\u9a6c\u66ff\u5c3c\u7247\uff09<\/span><\/span>\u7684\u8d85\u957f\u7814\u53d1\u53f2\u3002\u4ece\u53d1\u73b0\u9776\u70b9\u5230<\/span><\/span> 2001 <\/span>\u5e74\u83b7\u6279\u4e0a\u5e02\uff0c\u8bfa\u534e\u6295\u8d44\u8d85\u8fc7<\/span><\/span>50<\/span>\u4ebf\u7f8e\u5143\uff0c\u76f4\u63a5\u6210\u5c31\u4e86<\/span><\/span>5<\/span>\u4f4d\u7f8e\u56fd\u79d1\u5b66\u9662\u9662\u58eb\uff0c\u8fd8\u50ac\u751f\u4e86\u4e24\u9879\u8db3\u4ee5\u83b7\u5f97\u8bfa\u5956\u7684\u91cd\u5927\u53d1\u73b0\u3002<\/span><\/span>\u521b\u9020\u4e00\u6b3e\u65b0\u836f\uff0c\u4ed6\u4eec\u662f\u5f53\u4e4b\u65e0\u6127\u7684\u836f\u795e\u3002\u9884\u9632\u504f\u5934\u75db\u7684<\/span><\/span>Aimovig (erenumab-aooe)<\/span>\u662f\u5176\u4e2d\u4e4b\u4e00\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

2018\u5e74<\/span>05<\/span>\u6708\uff0c<\/span>FDA<\/span>\u6279\u51c6\u4e00\u6b3e\u5168\u65b0\u7684\u836f\u7269\uff0c\u5b89\u8fdb\u7814\u53d1\u7684<\/span><\/span>Aimovig (erenumab-aooe)<\/span>\u3002\u8bb8\u591a\u79d1\u5b66\u5bb6\u8ba4\u4e3a\u53ef\u4ee5\u4ece\u6839\u672c\u4e0a<\/span><\/span>\u9884\u9632<\/span><\/span>\u504f\u5934\u75db\u3002\u8be5\u836f\u963b\u65ad\u4e86\u4e00\u79cd\u540d\u4e3a\u964d\u9499\u7d20\u57fa\u56e0\u76f8\u5173\u80bd<\/span>( Calcitonin gene related peptide<\/span>\uff0c<\/span><\/span>CGRP) \u7684\u6d3b\u6027\uff0c\u8be5\u5206\u5b50\u5728\u504f\u5934\u75db\u53d1\u4f5c\u671f\u95f4\u51fa\u73b0\u5cf0\u503c\u3002<\/span>CGRP<\/span>\u662f\u201c\u8fc4\u4eca\u4e3a\u6b62\u6700\u6709\u6548\u7684\u504f\u5934\u75db\u9776\u70b9\u201d\uff0c\u795e\u7ecf\u5b66\u5bb6<\/span>David Dodick<\/span>\u8bf4\u3002\u5b83\u53ef\u80fd\u89e3\u51b3\u4ec0\u4e48<\/span><\/span>\u4e86\u80fd<\/span><\/span>\u89e6\u53d1\u504f\u5934\u75db\u7684\u6570\u767e\u5e74\u96be\u9898\u3002<\/span><\/span>\u5b9e\u9645\u4e0a\uff0c\u5173\u4e8e<\/span><\/span>\u504f\u5934\u75db<\/span><\/span>\u7684\u8bb0\u8f7d\u7531\u6765\u5df2\u4e45\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u8fc7\u91cf\u7684<\/span>\u201c\u9ec4\u80c6\u6c41\u201d\u5f15\u8d77\u504f\u5934\u75db\uff1fNO<\/span>\uff01<\/span><\/span><\/strong><\/p>\n

 <\/span><\/p>\n

\u53e4\u5e0c\u814a\u7684\u540d\u533b\u5e0c\u6ce2\u514b\u62c9\u5e95\u5728\u516c\u5143\u524d<\/span>5\u4e16\u7eaa<\/span><\/span>\u5c31<\/span><\/span>\u8be6\u7ec6\u63cf\u8ff0\u4e86\u504f\u5934\u75db\u7684\u53d1\u4f5c\uff0c\u5927\u7ea6\u4e94\u5206\u4e4b\u4e00\u7684\u60a3\u8005\u5728\u53d1\u4f5c\u524d\u51e0\u5206\u949f\u770b\u5230\u53d1\u5149\u3001\u95ea\u70c1\u7684<\/span>\u201c\u5149\u73af\u201d\u3002<\/span>\u4e00\u4e9b\u60a3\u8005<\/span><\/span>\u5455\u5410<\/span><\/span>\uff0c<\/span><\/span>\u4f3c\u4e4e\u7f13\u89e3\u4e86\u4e00\u4e9b\u75c7\u72b6\uff0c\u5e0c\u6ce2\u514b\u62c9\u5e95\u8ba4\u4e3a\u5934\u75db\u662f\u7531\u4e8e\u8fc7\u91cf\u7684<\/span>\u201c\u9ec4\u80c6\u6c41\u201d\u9020\u6210\u7684\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u6536\u7f29\u8840\u7ba1<\/span><\/span><\/strong>\u80fd\u6cbb\u7597\u504f\u5934\u75db\uff1f<\/span><\/span><\/strong><\/p>\n

 <\/span><\/p>\n

\u5230\u4e86<\/span>20\u4e16\u7eaa\u4e2d\u671f\uff0c\u5927\u591a\u6570\u533b\u751f\u8ba4\u4e3a\u5934\u90e8\u6269\u5f20\u7684\u52a8\u8109\u548c\u9759\u8109<\/span><\/span>\u8840\u7ba1<\/span><\/span>\u662f\u8fd9\u79cd\u75be\u75c5\u7684\u5173\u952e\u56e0\u7d20\uff0c\u56e0\u4e3a\u8bb8\u591a\u60a3\u8005\u611f\u89c9\u8fd9\u4e9b\u8840\u7ba1\u5728\u53d1\u4f5c\u671f\u95f4<\/span><\/span>\u8df3\u52a8<\/span><\/span>\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u795e\u7ecf\u5b66\u5bb6<\/span>Marcelo Bigal<\/span>\u8bf4<\/span><\/span>\uff0c\u8bb8\u591a\u65e9\u671f\u7597\u6cd5\u662f\u6536\u7f29\u8840\u7ba1\u3002\u7b2c\u4e00\u79cd\u6b64\u7c7b\u836f\u7269<\/span><\/span>\u4e3a<\/span><\/span>\u9ea6\u89d2\u80fa\uff0c\u662f\u6765\u81ea\u9ea6\u89d2\u83cc\u7684\u8840\u7ba1\u6536\u7f29\u5242\uff0c\u5b83\u751f\u957f\u5728\u9ed1\u9ea6\u548c\u5176\u4ed6\u8c37\u7269\u4e0a\uff0c<\/span><\/span>\u5728<\/span><\/span>\u4e2d\u4e16\u7eaa<\/span><\/span>\u66fe<\/span><\/span>\u5f15\u8d77\u5927\u89c4\u6a21\u4e2d\u6bd2\u3002\u5927\u5242\u91cf\u7684\u9ea6\u89d2\u83cc\u53ef<\/span><\/span>\u80fd\u5f15\u8d77<\/span><\/span>\u766b\u75eb\u53d1\u4f5c\uff0c\u5c0f\u5242\u91cf\u6709\u65f6\u53ef\u4ee5\u7f13\u89e3\u504f\u5934\u75db\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u7136\u800c\uff0c\u9ea6\u89d2\u80fa<\/span><\/span>\u80fd<\/span><\/span>\u4f7f\u8840\u7ba1<\/span><\/span>\u72ed\u7a84<\/span><\/span>\uff0c<\/span><\/span>\u8fd9\u5f88<\/span><\/span>\u5371\u9669<\/span><\/span>\u3002<\/span><\/span>\u66f2\u5766\u7c7b\u836f\u7269<\/span><\/span>\u80fd<\/span><\/span>\u9009\u62e9\u6027\u5730\u6536\u7f29\u5927\u8111\u7684\u8840\u7ba1<\/span><\/span>\uff0c<\/span><\/span>\u8fd9\u5f88\u53d7<\/span><\/span>\u533b\u751f\u548c\u60a3\u8005\u6b22\u8fce\u3002\u66f2\u5766\u7c7b\u836f\u7269\u5728<\/span>20\u4e16\u7eaa<\/span>90<\/span>\u5e74\u4ee3\u4e0a\u5e02\uff0c\u81f3\u4eca\u4ecd\u7136\u662f\u6700\u5e7f\u6cdb\u4f7f\u7528\u7684\u504f\u5934\u75db\u836f\u7269\uff0c\u53ef\u4ee5\u51cf\u5c11\u5927\u7ea6<\/span>50<\/span>\uff05\u81f3<\/span>60<\/span>\uff05\u7684\u504f\u5934\u75db\u53d1\u4f5c\u3002\u7136\u800c\uff0c\u5b83\u4eec\u4e0d\u662f\u5bf9\u6bcf\u4e2a\u4eba\u90fd\u8d77\u4f5c\u7528\uff0c\u5e76\u4e14\u548c\u8bb8\u591a\u6b62\u75db\u836f\u4e00\u6837\u6709\u5171\u540c\u7684\u4e0d\u826f\u526f\u4f5c\u7528\uff1a\u5982\u679c\u7ecf\u5e38\u670d\u7528\uff0c\u5934\u75db\u53ef\u80fd\u53d8\u5f97\u66f4\u52a0\u9891\u7e41\u548c\u4e25\u91cd\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u54e5\u672c\u54c8\u6839\u5927\u5b66\u7684\u795e\u7ecf\u75c5\u5b66\u5bb6<\/span>Jes Olesen\u6307\u51fa\u4e00\u7cfb\u5217\u8be6\u7ec6\u7684\u529f\u80fd\u6027\u78c1\u5171\u632f\u6210\u50cf\uff08<\/span>fMRI<\/span>\uff09\u8840\u7ba1\u7814\u7a76\uff0c\u663e\u793a\u5927\u8111\u5f02\u5e38\u8840\u6d41\u4e0e\u504f\u5934\u75db\u53d1\u4f5c\u65e0\u5173\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u795e\u7ecf\u9012\u8d28<\/span><\/span><\/strong>\u963b\u65ad\u5242<\/span>\u2014\u2014P<\/span>\u7269\u8d28<\/span><\/span><\/strong><\/p>\n

 <\/span><\/p>\n

\u968f\u7740\u504f\u5934\u75db\u7684\u8840\u7ba1\u7406\u8bba\u88ab\u8d28\u7591\uff0c\u7814\u7a76\u4eba\u5458\u5bfb\u627e\u5176\u4ed6\u6f5c\u5728\u7684\u56e0\u7d20\u3002<\/span><\/span>\u5176\u4e2d<\/span><\/span>\u4e00\u4e2a\u662f\u5927\u8111\u4e2d\u6b63\u5e38\u7535\u6d3b\u52a8\u7684\u7834\u574f\uff1a\u4e00\u79cd\u79f0\u4e3a\u76ae\u8d28\u6269\u6563\u6291\u5236\uff08<\/span>CSD\uff09\u7684\u766b\u75eb\u73b0\u8c61\u3002\u54c8\u4f5b\u5927\u5b66\u4e00\u540d\u7814\u7a76\u504f\u5934\u75db\u4eba\u5458<\/span><\/span>Michael Moskowitz<\/span>\u8bf4\uff0c\u8fd9\u79cd\u5f02\u5e38\u795e\u7ecf\u5143\u5174\u594b\u7684\u6162\u6ce2\u901a\u5e38\u59cb\u4e8e\u5927\u8111\u540e\u90e8\u7684\u6795\u53f6\uff0c\u5e76\u4ee5\u6bcf\u5206\u949f\u7ea6<\/span>2\u6beb\u7c73\u81f3<\/span>3<\/span>\u6beb\u7c73\u7684\u901f\u5ea6\u6269\u6563\uff0c\u4e0e\u8bb8\u591a\u504f\u5934\u75db\u60a3\u8005\u7684\u5148\u5146\u76f8\u5173\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u57fa\u4e8e\u5bf9\u556e\u9f7f\u52a8\u7269\u7684\u5b9e\u9a8c\uff0c<\/span><\/span>Michael Moskowitz<\/span>\u8ba4\u4e3a<\/span>CSD\u53ef\u4ee5\u901a\u8fc7\u523a\u6fc0\u795e\u7ecf\u7f51\u7edc\u6765\u89e6\u53d1\u504f\u5934\u75db\uff0c<\/span><\/span>\u8be5<\/span><\/span>\u795e\u7ecf\u7f51\u7edc\u662f\u652f\u914d\u8111\u8840\u7ba1\u7684\u4e09\u53c9\u795e\u7ecf\u8840\u7ba1\u7cfb\u7edf\u3002<\/span><\/span>Michael Moskowitz<\/span>\u7684\u5b9e\u9a8c\u5ba4\u4e8e<\/span>20\u4e16\u7eaa<\/span>80<\/span>\u5e74\u4ee3\u53d1\u73b0\u4e86\u8fd9\u4e00\u7cfb\u7edf\uff0c\u5f53\u65f6\u4ed6\u4eec\u8ffd\u8e2a\u4e86\u4e00\u7ec4\u795e\u7ecf\u7ea4\u7ef4\uff0c\u8fd9\u4e9b\u795e\u7ecf\u7ea4\u7ef4\u4ece\u5927\u8111\u548c\u810a\u9ad3\u7684\u8111\u819c\u3001\u7ec6\u80de\u819c\u7684\u8840\u7ba1\u8f90\u5c04\u5230\u652f\u914d\u9762\u90e8\u3001\u5934\u90e8\u3001\u4e0b\u989a\u7684\u4e09\u53c9\u795e\u7ecf\u3002<\/span><\/span>Michael Moskowitz<\/span>\u63d0\u51fa\uff0c\u5f53\u8fd9\u4e9b\u795e\u7ecf\u53d7\u5230<\/span>CSD\u6216\u5176\u4ed6\u56e0\u7d20\u523a\u6fc0\u65f6\uff0c\u5c31\u4f1a\u51fa\u73b0\u504f\u5934\u75db\u3002\u4ed6\u8fd8\u63d0\u51fa\u963b\u6b62<\/span>P<\/span>\u7269\u8d28\u7684\u91ca\u653e\u53ef\u80fd\u4f1a\u7f13\u89e3\u504f\u5934\u75db\u60a3\u8005\u7684\u75c7\u72b6\uff0c<\/span>P<\/span>\u7269\u8d28\u662f\u5f53\u65f6\u552f\u4e00\u5df2\u77e5\u7684\u75bc\u75db\u4fe1\u53f7\u795e\u7ecf\u9012\u8d28\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u867d\u7136\u8bb8\u591a\u4eba\u76f8\u4fe1\u8be5\u5047\u8bbe\uff0c\u4f46\u591a\u9879\u65e8\u5728\u963b\u65ad<\/span>P\u7269\u8d28\u6d3b\u6027\u7684\u836f\u7269\u8bd5\u9a8c\u672a\u80fd\u963b\u6b62\u504f\u5934\u75db\u60a3\u8005\u7684\u6025\u6027\u53d1\u4f5c\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

CGRP<\/span><\/strong>\u2014\u2014<\/span><\/strong>\u53d1\u73b0\u4e8e<\/span>1982\u5e74<\/span><\/span><\/strong><\/p>\n

 <\/span><\/p>\n

P\u7269\u8d28\u963b\u65ad\u836f\u7269\u7684\u5931\u8d25\u4e3a<\/span>CGRP<\/span>\u6253\u5f00\u4e86\u5927\u95e8\u3002<\/span>CGRP<\/span>\u662f\u4e00\u79cd\u7684<\/span>37<\/span>\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\u7684\u591a\u80bd\uff0c\u7531\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u7684\u795e\u7ecf\u79d1\u5b66\u5bb6<\/span>Susan Amara<\/span>\u548c<\/span>Michael Rosenfeld<\/span>\u5076\u7136\u53d1\u73b0\u7684\u3002\u5728\u7814\u7a76\u4e00\u79cd\u53eb\u505a\u964d\u9499\u7d20\u7684\u7532\u72b6\u817a\u6fc0\u7d20\u65f6\uff0c<\/span>Amara<\/span>\u548c<\/span>Rosenfeld<\/span>\u53d1\u73b0\uff0c\u5728\u7532\u72b6\u817a\u4e2d\u7f16\u7801\u964d\u9499\u7d20\u7684\u540c\u4e00\u57fa\u56e0\u5728\u5927\u8111\u7684\u53e6\u4e00\u90e8\u5206\u4ea7\u751f\u4e00\u79cd\u7565\u5fae\u4e0d\u540c\u7684\u80bd\uff0c\u540c\u65f6\u6709\u52a9\u4e8e\u8c03\u8282\u4f53\u5185\u7684\u94a0\u548c\u9499\u6c34\u5e73\u3002\u5b83\u4f7f\u5355\u4e2a\u57fa\u56e0\u80fd\u591f\u4ea7\u751f\u591a\u79cd\u86cb\u767d\u8d28\uff0c\u8fd9\u4e00\u53d1\u73b0\u5728<\/span>1982<\/span>\u5e74\u53d1\u8868\u5728<\/span>Nature<\/span>\u4e0a\uff0c\u5f15\u8d77\u4e86\u8f70\u52a8\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u745e\u5178\u9686\u5fb7\u5927\u5b66\u7684\u795e\u7ecf\u5b66\u5bb6<\/span>Lars Edvinsson<\/span>\u53d1\u73b0<\/span>CGRP<\/span>\u5728\u6cbb\u7597\u75bc\u75db\u7684\u5927\u8111\u901a\u8def\u548c\u8c03\u8282\u8840\u6d41\u7684\u5927\u8111\u533a\u57df\u4e2d\u5b58\u5728\u4e30\u5bcc\u7684<\/span>CGRP<\/span>\u3002\u4ed6\u7684\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0<\/span>CGRP<\/span>\u53ef\u4ee5\u89e6\u53d1\u5f53\u65f6\u88ab\u8ba4\u4e3a\u662f\u5f15\u8d77\u504f\u5934\u75db\u7684\u6807\u8bb0\uff1a\u5f53\u4ece\u4e09\u53c9\u795e\u7ecf\u8840\u7ba1\u795e\u7ecf\u91ca\u653e\u65f6\uff0c\u5b83\u80fd\u5f3a\u70c8\u7684\u6269\u5c55\u5927\u8111\u8840\u7ba1\u3002<\/span>1990<\/span>\u5e74\uff0c\u4ece\u4e25\u91cd\u504f\u5934\u75db\u7684\u4eba\u7684\u9888\u9759\u8109\u53d6\u8840\u6837\u540e\uff0c\u7814\u7a76\u4eba\u5458\u68c0\u6d4b\u4e86\u504f\u5934\u75db\u53d1\u4f5c\u671f\u95f4\u548c\u4e4b\u540e\u4e00\u7cfb\u5217\u4e0d\u540c\u80bd\u7684\u542b\u91cf\uff0c\u5305\u62ec\u7269\u8d28<\/span>P<\/span>\u3002\u201c\u4ee4\u4eba\u60ca\u5947\u7684\u662f\uff0c<\/span>CGRP<\/span>\u662f\u552f\u4e00\u4e00\u79cd\u663e\u8457\u91ca\u653e\u7684\u80bd\u201d<\/span>Lars Edvinsson<\/span>\u8bf4\u3002<\/span>CGRP<\/span><\/span>\u5f00\u59cb\u4f5c\u4e3a\u6cbb\u7597\u504f\u5934\u75db\u7684\u9776\u70b9\u8fdb\u5165<\/span>\u201c\u836f\u795e\u201d\u7684\u89c6\u7ebf\u3002<\/span><\/p>\n

 <\/span><\/p>\n

CGRP\u963b\u6ede\u5242\u7684\u4e0a\u5e02\u4e4b\u8def<\/span><\/strong><\/p>\n

 <\/span><\/p>\n

\u8d77\u521d\uff0c<\/span>Edvinsson\u548c\u5176\u4ed6\u4eba\u8ba4\u4e3a<\/span>CGRP<\/span>\u901a\u8fc7\u6269\u5f20\u5927\u8111\u4e2d\u7684\u8840\u7ba1\u6765\u89e6\u53d1\u504f\u5934\u75db\u3002\u76f8\u53cd\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u8868\u660e\uff0c<\/span>CGRP<\/span>\u4e0d\u4ec5\u4ec5\u662f\u4e00\u79cd\u8840\u7ba1\u6269\u5f20\u5242\uff0c\u800c\u662f\u4e00\u79cd\u4ee5\u524d\u672a\u77e5\u7684\u75bc\u75db\u4fe1\u53f7\u795e\u7ecf\u9012\u8d28\u3002\u5176\u4ed6\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0c\u9888\u9759\u8109\u8840\u6db2\u4e2d<\/span>CGRP<\/span>\u6c34\u5e73\u5347\u9ad8\u8868\u660e\u504f\u5934\u75db\u53d1\u4f5c\u3002\u5728<\/span>2002<\/span>\u5e74\u4e00\u9879\u5173\u952e\u7684\u7814\u7a76\u4e2d\uff0c<\/span>Oleson<\/span>\u53ca\u5176\u540c\u4e8b\u5c06<\/span>CGRP<\/span>\u6ce8\u5165\u504f\u5934\u75db\u60a3\u8005\u7684\u8840\u6db2\u4e2d\uff0c\u53d1\u73b0\u4ed6\u4eec\u5728\u6570\u5c0f\u65f6\u5185\u51fa\u73b0\u4e86\u504f\u5934\u75db\u6837\u5934\u75db\uff0c\u800c\u975e\u504f\u5934\u75db\u60a3\u8005\u6700\u591a\u60a3\u6709\u8f7b\u5ea6\u5934\u75db\u3002<\/span>Oleson<\/span>\u8bf4\uff0c\u8fd9\u8868\u660e\u504f\u5934\u75db\u60a3\u8005\u5bf9\u80bd\u7684\u4f5c\u7528\u5f02\u5e38\u654f\u611f\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u5230<\/span>21\u4e16\u7eaa\u521d\uff0c\u5fb7\u56fd\u5236\u836f\u516c\u53f8<\/span>Boehringer Ingelheim<\/span>\u8bbe\u8ba1\u4e86\u4e00\u79cd\u540d\u4e3a<\/span>bibn4096bs<\/span>\u7684\u5c0f\u5206\u5b50\u6765\u963b\u65ad<\/span>CGRP<\/span>\u7684\u53d7\u4f53\u3002\u8be5\u836f\u53ef\u4ee5\u963b\u6b62\u4e00\u4e9b\u4eba\u7684\u6025\u6027\u504f\u5934\u75db\u53d1\u4f5c\uff0c\u4f46\u4f1a\u4ea7\u751f\u4e0d\u826f\u526f\u4f5c\u7528\u3002\u53e6\u4e00\u5bb6\u516c\u53f8<\/span>Merck<\/span>\u8bd5\u56fe\u7528\u4e0d\u540c\u7684\u5c0f\u5316\u5408\u7269\u963b\u65ad<\/span>CGRP<\/span>\u53d7\u4f53\u3002\u5b83\u4f3c\u4e4e\u4e5f<\/span><\/span>\u4f5c\u7528<\/span><\/span>\u5f88\u597d\uff0c\u4f46\u5b83\u7684\u8bd5\u9a8c\u4e5f\u4e0d\u5f97\u4e0d\u505c\u6b62\uff0c\u56e0\u4e3a\u5b83\u663e\u793a\u51fa\u809d\u6bd2\u6027\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

Pons<\/span>\u548c<\/span><\/span>\u540c\u4e8b\u4eec<\/span><\/span>\u5f00\u59cb\u63a2\u7d22\u5176\u4ed6\u65b9\u6cd5\u3002\u4ed6\u8ba4\u4e3a\uff0c\u4e5f\u8bb8\u6297\u4f53\u503c\u5f97\u4e00\u8bd5\uff0c\u56e0\u4e3a\u5b83\u4eec\u53ef\u4ee5\u5728\u4f53\u5185\u6301\u7eed\u5f88\u957f\u65f6\u95f4\uff0c\u5e76\u4e14\u53ef\u4ee5\u51cf\u5c11\u4eba\u4eec\u9700\u8981\u6ce8\u5c04\u7684\u9891\u7387\u3002\u4f46\u5927\u591a\u6570\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\u6297\u4f53\u901a\u5e38\u5206\u5b50\u91cf\u592a\u5927\u800c\u65e0\u6cd5\u901a\u8fc7\u8840\u8111\u5c4f\u969c\u3002\u5f53\u65f6\uff0c<\/span>\u201c\u5927\u591a\u6570\u4eba\u90fd\u6ca1\u6709\u8003\u8651\u4f7f\u7528\u6297\u4f53\u6765\u6cbb\u7597\u75bc\u75db\u201d\uff0c\u4f46\u4ed6\u8bf4\uff0cRinat<\/span>\u5df2\u7ecf\u5f00\u59cb\u8fdb\u884c\u4e0d\u540c\u6297\u4f53\u75bc\u75db\u6cbb\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u521d\u6b65\u7ed3\u679c\u5f88\u6709\u5e0c\u671b\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

2004\u5e74\uff0c<\/span>Rinat<\/span>\u63a8\u51fa\u4e86\u9488\u5bf9<\/span>CGRP<\/span>\u7684\u6297\u4f53\u8ba1\u5212\u3002\u5982\u679c\u5b83\u8d77\u4f5c\u7528\uff0c\u8be5\u56e2\u961f\u63a8\u65ad\uff0c<\/span><\/span>\u5373\u610f\u5473\u7740<\/span><\/span>\u901a\u8fc7\u4ec5\u5728\u5468\u56f4\u795e\u7ecf\u7cfb\u7edf\u4e2d\u963b\u65ad<\/span>CGRP\uff0c\u53ef\u4ee5\u6cbb\u7597\u5927\u8111\u5916\u7684\u504f\u5934\u75db\u3002\u8be5\u516c\u53f8\u5f00\u53d1\u4e86<\/span>CGRP<\/span>\u6297\u4f53\uff0c\u73b0\u5728\u7531<\/span>Teva<\/span>\u4ee5\u540d\u79f0<\/span>TEV-48125<\/span>\u8fdb\u884c\u6d4b\u8bd5\u3002<\/span>Rinat<\/span>\u56e2\u961f\u6210\u529f\u5f00\u5c55\u4e86\u4e00\u9879\u6d4b\u8bd5<\/span>TEV-48125<\/span>\u5b89\u5168\u6027\u7684\u7b2c\u4e00\u9636\u6bb5\u7814\u7a76\uff0c\u4f46\u8f89\u745e\u4e8e<\/span>2006<\/span>\u5e74\u6536\u8d2d\u4e86\u8be5\u516c\u53f8\uff0c\u5230<\/span>2011<\/span>\u5e74\uff0c\u8be5\u516c\u53f8\u201c\u51b3\u5b9a\u504f\u5934\u75db\u4e0d\u662f\u5b83\u60f3\u8981\u8ffd\u6c42\u7684\u9886\u57df\u201d\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u8fd9\u6bb5\u65f6\u95f4\uff0c\u504f\u5934\u75db\u836f\u7269\u7814\u7a76\u9047\u5230\u4e86\u4f4e\u4f30<\/span><\/span>\uff0c\u5927\u516c\u53f8<\/span><\/span>\u7eb7\u7eb7\u6401\u7f6e\u7814\u7a76\u8ba1\u5212<\/span><\/span>\u3002\u5bf9\u65b0\u578b\u504f\u5934\u75db\u836f\u7269\u5e02\u573a\u4ef7\u503c\u7684\u4f30\u8ba1\u5c1a\u4e0d\u786e\u5b9a\uff0c\u4ece\u7ea6<\/span>2\u4ebf\u7f8e\u5143\u5230<\/span>50<\/span>\u4ebf\u7f8e\u5143\u4e0d\u7b49\uff0c\u516c\u53f8\u5f88\u96be\u6295\u5165\u5927\u91cf\u8d44\u91d1\u7528\u4e8e\u836f\u7269\u5f00\u53d1\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u5c3d\u7ba1\u5b58\u5728\u98ce\u9669\uff0c\u4f46<\/span>2013\u5e74\u4e00\u5bb6\u540d\u4e3a<\/span>venBio<\/span>\u7684\u98ce\u9669\u6295\u8d44\u516c\u53f8\u8d2d\u4e70\u4e86<\/span>TEV-48125<\/span>\u7684\u6743\u5229\uff0c\u5e76\u6210\u7acb\u4e86\u4e00\u5bb6\u540d\u4e3a<\/span>Labrys Biologics<\/span>\u7684\u65b0\u516c\u53f8\uff0c\u7ee7\u7eed\u5f00\u5c55\u6297\u4f53\u7684\u4e34\u5e8a\u5f00\u53d1\u3002\u795e\u7ecf\u79d1\u5b66\u5bb6<\/span>Corey Goodman<\/span>\u662f\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u65e7\u91d1\u5c71\u7684<\/span>venBio<\/span>\u7684\u7ba1\u7406\u5408\u4f19\u4eba\uff0c\u76f4\u5230<\/span>2009<\/span>\u5e74\u62c5\u4efb\u8f89\u745e\u516c\u53f8\u751f\u7269\u533b\u836f\u90e8\u95e8\u7684\u603b\u88c1\uff0c\u5728\u90a3\u91cc\u4ed6\u8d1f\u8d23\u76d1\u7ba1<\/span>Rinat<\/span>\u548c<\/span>Pons<\/span>\u7684\u56e2\u961f\u3002<\/span>Goodman<\/span>\u8bb0\u5f97<\/span>TEV-48125<\/span>\u662f\u4e00\u79cd\u201c\u975e\u5e38\u597d\u7684\u6297\u4f53\u201d\uff0c\u5728\u5f15\u5165\u4e86\u66f4\u591a\u7684\u6295\u8d44\u8005\u4e4b\u540e\uff0c<\/span>Labrys<\/span>\u5f00\u59cb\u5bf9\u9891\u7e41\u504f\u5934\u75db\u60a3\u8005\u8fdb\u884c\u4e24\u9879<\/span>II<\/span>\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8fd9\u9879\u8bd5\u9a8c\u4ea7\u751f\u4e86\u201c\u6211\u89c1\u8fc7\u7684\u6700\u7f8e\u4e3d\u7684<\/span>II<\/span>\u671f\u6570\u636e\u201d\uff0c<\/span>Goodman<\/span>\u8bf4\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u5934\u75db\u5929\u6570\u660e\u663e\u51cf\u5c11\uff0c\u5373\u4f7f\u662f\u6700\u4e25\u91cd\u7684\u60c5\u51b5\u4e5f\u662f\u5982\u6b64\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

Teva\u4e8e<\/span>2014<\/span>\u5e74\u6536\u8d2d\u4e86<\/span>Labrys<\/span>\uff0c\u4e0e<\/span>Alder Biopharmaceuticals<\/span>\uff0c<\/span>Eli Lilly<\/span>\u548c<\/span>Amgen<\/span>\u7ade\u4e89\uff0c\u4ee5\u83b7\u5f97<\/span>FDA<\/span>\u6279\u51c6\u7684\u7b2c\u4e00\u79cd\u504f\u5934\u75db\u6297\u4f53\u836f\u7269\u3002<\/span>Amgen<\/span><\/span>\u6700\u7ec8\u8d62\u5f97\u4e86\u7ade\u4e89\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u98a0\u8986\u504f\u5934\u75db\u5e02\u573a\u7684<\/span><\/span><\/strong>CGRP<\/span><\/strong>\u963b\u6ede\u5242<\/span><\/span><\/strong><\/p>\n

 <\/span><\/p>\n

\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u8bc1\u5b9e\uff0c<\/span>CGRP\u662f\u504f\u5934\u75db\u7684\u4e3b\u8981\u9776\u70b9\uff0c\u751a\u81f3\u53ef\u80fd\u662f\u6839\u672c\u56e0\u7d20\u3002<\/span>CGRP<\/span><\/span>\u5728\u504f\u5934\u75db\u6cbb\u7597\u65b9\u9762\u7684\u4ef7\u503c\u5f97\u5230\u786e\u8ba4\u3002<\/span><\/span>Aimovig (erenumab-aooe)<\/span>\u4f5c\u4e3a\u5168\u7403\u4e0a\u5e02\u7684\u7b2c\u4e00\u6b3e<\/span>CGRP\u6297\u4f53\uff0c\u4e0d\u540c\u4e0e\u66f2\u5766\u7c7b\u836f\u7269\uff0c\u5b83\u6700\u5927\u7684\u4eae\u70b9\u662f\u53ef\u4ee5\u9884\u9632\u504f\u5934\u75db\u3002\u9009\u62e9\u6027<\/span>5 – HT1B\/1D <\/span>\u53d7\u4f53\u6fc0\u52a8\u5242\u7684\u66f2\u5766\u7c7b\u836f\u7269\u56e0\u5176\u826f\u597d\u7684\u4e34\u5e8a\u6cbb\u7597\u6548\u679c\u6210\u4e3a\u504f\u5934\u75db\u6cbb\u7597\u7684\u9996\u9009\u836f\u7269\u3002\u9996\u4e2a\u66f2\u5766\u7c7b\u836f\u7269\u8212\u9a6c\u666e\u5766\u4e8e <\/span>1991 <\/span>\u5e74\u95ee\u4e16\u3002\u4e0d\u8fc7\uff0c\u81ea <\/span>2002 <\/span>\u5e74 <\/span>12 <\/span>\u6708\u7f8e\u56fd<\/span>FDA<\/span>\u6279\u51c6\u6700\u540e\u4e00\u6b3e\u66f2\u5766\u7c7b\u836f\u7269\u4f9d\u5229\u66f2\u5766\u81f3\u4eca\u7684\u8fd1<\/span>16<\/span>\u5e74\u7684\u65f6\u95f4\u91cc\uff0c\u5c1a\u65e0\u4e00\u6b3e\u5177\u6709\u7a81\u7834\u6027\u7684\u6297\u504f\u5934\u75db\u836f\u7269\u95ee\u4e16\u3002\u76f4\u5230<\/span><\/span>Aimovig (erenumab-aooe)<\/span>\u7684\u95ee\u4e16\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

EvaluatePharma<\/span>\u9884\u6d4b<\/span><\/span>Aimovig (erenumab-aooe)<\/span>\u5728<\/span>2024\u5e74\u5c06\u6210\u4e3a\u9500\u552e\u989d\u6700\u5927\u7684\u504f\u5934\u75db\u6297\u4f53\u836f\u7269\uff0c\u8fbe<\/span>18.82<\/span>\u4ebf\u7f8e\u5143\uff0c\u59a5\u59a5\u7684\u91cd\u78c5\u70b8\u5f39\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n<\/p>\n

 <\/span><\/p>\n

\u5199\u5728\u7ed3\u5c3e<\/span><\/span><\/strong><\/p>\n

 <\/span><\/p>\n

\u300a\u6211\u4e0d\u662f\u836f\u795e\u300b\uff0c\u4e00\u90e8\u7535\u5f71\uff0c\u7275\u52a8\u4e86\u56fd\u4eba\u7684\u5fc3\uff0c\u7535\u5f71\u4e2d\u4eba\u7269\u7684\u906d\u9047\uff0c<\/span><\/span>\u5f88\u591a<\/span><\/span>\u4eba\u90fd\u53ef\u80fd\u4f1a\u9047\u5230\uff1a\u65e0\u836f\u53ef\u7528\uff0c\u8d85\u9ad8\u836f\u4ef7\uff0c\u90bb\u56fd\u4e3a\u4ec0\u4e48\u90fd\u53ef\u4ee5\uff0c\u6211\u4eec\u4e3a\u4ec0\u4e48\u5c31\u53ea\u80fd\u7b49\u6b7b\u3002\u8fd9\u4e9b\u95ee\u9898\u592a\u8fc7\u5b8f\u5927\uff0c\u7262\u9a9a\u57cb\u6028\uff0c\u6beb\u65e0\u7528\u5904\u3002\u5b83\u7684\u89e3\u51b3\u6709\u8d56\u4e8e\u666e\u7f57\u5927\u4f17\u7684\u6301\u7eed\u5173\u6ce8\u3001\u53cd\u9988\uff0c\u6743\u5a01\u4eba\u58eb\u7684\u8ba4\u540c\uff0c\u4e0a\u5c42\u5efa\u7b51\u7684\u6539\u9769\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u6709\u4eba\u8bf4\uff0c\u836f\u4ef7\u4e4b\u6240\u4ee5\u6602\u8d35\uff0c\u90a3\u662f\u4f60\u4e70\u5230\u7684\u5df2\u7ecf\u662f\u7b2c\u4e8c\u9897\u4e86\uff0c\u7b2c\u4e00\u9897\u4ef7\u503c\u662f\u6570\u5341\u4ebf\u7f8e\u5143\u3002\u4f46\u662f\u600e\u4e48\u5e73\u8861\u4f01\u4e1a\u7684\u5229\u76ca\u548c\u666e\u7f57\u5927\u4f17\u7684\u798f\u7949\uff0c\u8003\u9a8c\u7684\u662f\u6574\u4e2a\u793e\u4f1a\u548c\u4e0a\u5c42\u5efa\u7b51\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u65b0\u836f\u8bda\u53ef\u8d35\uff0c\u521b\u65b0\u4ef7\u66f4\u9ad8\u3002\u82e5\u4e3a\u6551\u547d\u6545\uff0c\u4e8c\u8005\u7686\u53ef\u629b\uff1f<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u53c2\u8003\u6587\u732e<\/span><\/span><\/p>\n

FDA just approved the first drug to prevent migraines. Here\u2019s the story of its discovery\u2014and its limitations<\/span>.<\/span><\/p>\n

\u683c\u5217\u536b\u8bde\u751f\u8bb0\uff1a\u96be\u4ee5\u590d\u5236\u7684\u6297\u764c\u5947\u8ff9<\/span>. \u836f\u660e\u5eb7\u5fb7<\/span><\/span><\/p>\n

\u4e2d\u56fd\u4eba\u4e3a\u4ec0\u4e48\u7528\u4e0d\u4e0a\u5e73\u4ef7\u6551\u547d\u836f<\/span>. \u5927\u8c61\u516c\u4f1a<\/span><\/span><\/p>\n

FDA approves novel preventive treatment for migraine<\/span><\/p>\n

\u6211\u4e0d\u662f\u836f\u795e\uff1a\u4eff\u5236\u836f\u4e0e\u539f\u7814\u836f\u80cc\u540e\u7684\u6545\u4e8b\uff0c\u6700\u8bbd\u523a\u7684\u6700\u5fc3\u9178\uff0c\u6700\u8352\u8bde\u7684\u6700\u771f\u5b9e\uff01<\/span><\/p>\n

\u6297\u504f\u5934\u75db\u836f\u7269\u8c03\u7814\u62a5\u544a<\/span><\/p>\n

\n

\u6392\u7248\uff1aHerman<\/span>
<\/p>\n

\n
\n
\n
\u5e7f\u800c\u544a\u4e4b<\/section>\n<\/section>\n<\/section>\n
\n
\n

\u2299 \u540c\u5199\u610f\u57f9\u8bad<\/span><\/p>\n

\u5199\u610f\u8bba\u575b\u4e28\u65b0\u836f\u4e2d\u7f8e\u53cc\u62a5\u4e4b\u5236\u5242\u6eb6\u51fa\u6280\u672f\u5f00\u53d1<\/a><\/span><\/p>\n

\u5199\u610f\u8bba\u575b\u4e28\u56fd\u9645\u89c4\u8303\u4e0b\u751f\u7269\u836f\u5168\u751f\u547d\u5468\u671f\u8d28\u91cf\u7ba1\u7406<\/a><\/span><\/p>\n

\u5199\u610f\u516c\u76ca\u4e28\u4eff\u5236\u836f\u4e00\u81f4\u6027\u8bc4\u4ef7\u5927\u76d8\u70b9\u4e0e\u603b\u51b3\u6218<\/span><\/a><\/p>\n

\u6ee1\u8db3IND\/NDA\u4e2d\u7f8e\u53cc\u62a5\u7684\u53e3\u670d\u65b0\u836f\u5236\u5242\u7814\u53d1<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n

\"\u521b\u9020\u7b2c\u4e00\u6b3e\u9884\u9632\u504f\u5934\u75db\u836f\u7269\uff1a\u4ed6\u4eec\u662f\u836f\u795e\"<\/p>\n

\u836f\u4e8b\u7eb5\u6a2a\u662f\u4e00\u4e2a\u5f00\u653e\uff0c\u7531\u81ea\u613f\u8005\u7ec4\u6210\u7684\u56e2\u4f53\uff0c\u73b0\u6709\u6210\u545838\u540d\uff0c\u5206\u522b\u4e3aVoyager88\uff08\u9b4f\u5229\u519b\uff09\uff0c\u96f7\u8bfa\u5c9b\uff0c\u4e09\u5206\u8bdd\uff0cHerman\uff0c\u6885\u5e0c\uff0c\u6587\u7af9\uff0cduke\uff0cyhqqqqq\uff0c\u5360\u5c0f\u5175\uff0c\u98ce\u4e00\u6837\u7684\u5c4e\u58f3\u90ce\uff0c\u9526\u5fc3\u7ee3\u53e3\uff0cflydp511\uff0c\u5de7\u5de7\uff0c\u4e91\u6c34\u9053\u4eba\uff0c\u9621\u4e0a\u964c\u964c\uff0c\u591a\u5df4\u80fa\uff0c\u745c\u513f\uff0cKailyn\uff0cSmall fish\uff0c\u5b50\u708e\uff0c\u514b\u683c\u83ab\uff0cVicky\uff0cPandada\uff0c\u83ab\u5306\u5306\uff0cSophia \uff0c\u4f9d\u7136\u7279\u96f7\u897f\uff0c\u5076\u9635\u96e8\uff0cAimee\uff0c\u4ed6\u5c71\u4e4b\u77f3\uff0c\u5510\u5c0f\u7396\uff0c\u96f6\u4e0b274\u2103\uff0cGloria\uff0cBreathless\uff0cLuffy\uff0c\u80e1\u4e0d\u559c\uff0c Helen\uff0c\u843d\u843d\uff0cSUNRISE\u3002\u6b22\u8fce\u6709\u5fd7\u4e4b\u58eb\u52a0\u5165\u6211\u4eec\u56e2\u961f\u3002\u6295\u7a3f\u3001\u5408\u4f5c\u3001\u52a0\u4e13\u4e1a\u7fa4\u8bf7\u52a0\u5fae\u4fe1442015666\uff0c\u836f\u4e8b\u7eb5\u6a2a\u4e8c\u5343\u4ebaQQ\u7fa422711855\u3002<\/span><\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u836f\u4e8b\u7eb5\u6a2a <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u6bcf\u4e00\u4e2a\u65b0\u836f\u7684\u95ee\u4e16\u90fd\u662f\u4f20\u5947\uff0c\u95ee\u9898\u7684\u4e0d\u65ad\u51fa\u73b0\uff0c\u5230\u95ee\u9898\u7684\u76f8\u7ee7\u89e3\u51b3\uff0c\u65e0\u4e0d\u8868\u73b0\u51fa\u4e86\u79d1\u5b66\u5bb6\u548c\u7ba1\u7406\u8005\u7684\u667a\u6167\u3001\u679c\u65ad\u548c\u6267\u7740\u3002\u4ece\u5b83 […]<\/p>\n","protected":false},"author":1,"featured_media":20001,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/20000"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=20000"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/20000\/revisions"}],"predecessor-version":[{"id":20008,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/20000\/revisions\/20008"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/20001"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=20000"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=20000"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=20000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}