{"id":20050,"date":"2018-07-17T01:00:00","date_gmt":"2018-08-08T01:16:22","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/08\/%e7%be%8e%e5%9b%bd%e4%b8%8e%e6%ac%a7%e7%9b%9f%e5%af%b9api%e4%b8%8e%e8%be%85%e6%96%99%e7%9b%b8%e4%ba%92%e4%bd%9c%e7%94%a8%e5%bd%b1%e5%93%8dbe%e7%9c%8b%e6%b3%95\/"},"modified":"2018-08-08T09:16:24","modified_gmt":"2018-08-08T01:16:24","slug":"%e7%be%8e%e5%9b%bd%e4%b8%8e%e6%ac%a7%e7%9b%9f%e5%af%b9api%e4%b8%8e%e8%be%85%e6%96%99%e7%9b%b8%e4%ba%92%e4%bd%9c%e7%94%a8%e5%bd%b1%e5%93%8dbe%e7%9c%8b%e6%b3%95","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/20050\/","title":{"rendered":"\u7f8e\u56fd\u4e0e\u6b27\u76df\u5bf9API\u4e0e\u8f85\u6599\u76f8\u4e92\u4f5c\u7528\u5f71\u54cdBE\u770b\u6cd5"},"content":{"rendered":"
\n

\u7ffb\u8bd1\uff1avicky<\/span><\/p>\n


<\/span><\/p>\n

\u672c\u6587\u4e3a\u9009\u8bd1\u5185\u5bb9\uff0c\u4e3b\u8981\u9610\u8ff0\u4e86\u7f8e\u56fd\u548c\u6b27\u76df\u5bf9<\/span>API<\/span>\u548c\u8f85\u6599\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u5f71\u54cd\u751f\u7269\u7b49\u6548\u6027\u770b\u6cd5\u548c\u89c2\u70b9\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u7f8e\u56fd\u4e0e\u6b27\u76df\u5bf9API\u4e0e\u8f85\u6599\u76f8\u4e92\u4f5c\u7528\u5f71\u54cdBE\u770b\u6cd5\"<\/p>\n


<\/p>\n

FDA\u5173\u4e8e\u57fa\u4e8e<\/span>BCS\u7684\u901f\u91ca\u56fa\u4f53\u53e3\u670d\u5242\u578b<\/span>BA\u548c<\/span>BE\u7814\u7a76\u8c41\u514d\u6307\u5357<\/span><\/strong><\/span><\/p>\n

\u8be5<\/span>US-FDA<\/span>\u6307\u5357\uff08\u7f8e\u56fd\u536b\u751f\u548c\u4eba\u7c7b\u670d\u52a1\u90e8\uff0c<\/span>2000<\/span>\uff09\u6307\u51fa\uff1a<\/span>\u201c<\/span>\u901a\u5e38\u60c5\u51b5\u4e0b\uff0c\u4f7f\u7528\u76ee\u524d<\/span>FDA<\/span>\u6279\u51c6\u7684<\/span>IR<\/span>\u56fa\u4f53\u53e3\u670d\u5242\u578b\u4e2d\u7684\u8f85\u6599\u4e0d\u4f1a\u5f71\u54cd\u5feb\u901f\u6eb6\u89e3\u7684<\/span>IR<\/span>\u4ea7\u54c1\u4e2d\u9ad8\u6eb6\u89e3\u5ea6\u548c\u9ad8\u6e17\u900f\u6027\u539f\u6599\u836f\u7684\u5438\u6536\u901f\u7387\u6216\u5438\u6536\u7a0b\u5ea6\u3002\u4e3a\u652f\u6301\u751f\u7269\u8c41\u514d\u7533\u8bf7\uff0c<\/span>IR<\/span>\u836f\u54c1\u4e2d\u7684\u8f85\u6599\u542b\u91cf\u5e94\u4e0e\u9884\u671f\u529f\u80fd\uff08\u4f8b\u5982\uff1a\u6da6\u6ed1\u5242\uff09\u4e00\u81f4\u3002\u5927\u91cf\u7684\u67d0\u79cd\u8f85\u6599\uff0c\u4f8b\u5982\u8868\u9762\u6d3b\u6027\u5242\uff08\u5982\uff1a\u805a\u5c71\u68a8\u9187\u916f<\/span>80<\/span>\uff09\u548c\u751c\u5473\u5242\uff08\u5982\uff1a\u7518\u9732\u9187\u6216\u5c71\u68a8\u7cd6\u9187\uff09\u53ef\u80fd\u4f1a\u6709\u95ee\u9898\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u56e0\u6b64\uff0c\u8be5\u6307\u5357\u6697\u793a\u5c11\u91cf\u4f7f\u7528\u8fd9\u4e9b<\/span>\u201c<\/span>\u6d3b\u6027<\/span>\u201d<\/span>\u8f85\u6599\u4e0d\u4f1a\u9020\u6210\u95ee\u9898\u3002\u9274\u4e8e\u4e00\u4e9b\u5229\u57f9\u916e\u4eff\u5236\u836f\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u7684\u53d1\u73b0\uff0c\u8fd9\u79cd\u89c2\u70b9\u662f\u503c\u5f97\u6000\u7591\u7684\u3002<\/span>
<\/span><\/p>\n

\u57fa\u4e8e\u836f\u5178\u6807\u51c6\uff0c\u5229\u57f9\u916e\u4f20\u7edf\u4e0a\u88ab\u8ba4\u4e3a\u662f\u4f4e\u6eb6\u89e3\u5ea6\u836f\u7269\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5176\u4f4e\u6cbb\u7597\u5242\u91cf\u6216\u89c4\u683c\uff0c\u5c31<\/span>BCS<\/span>\u5206\u7c7b\u800c\u8a00\uff0c\u5b83\u53ef\u88ab\u8ba4\u4e3a\u662f\u9ad8\u5ea6\u53ef\u6eb6\u6027\u836f\u7269\u3002\u901a\u8fc7\u6210\u76d0\u63d0\u9ad8\u4e86\u5229\u57f9\u916e\u7684\u6eb6\u89e3\u5ea6\uff0c\u5728\u7f13\u51b2\u6db2\u4e2d\u7684\u6eb6\u89e3\u5ea6\u9ad8\u4e8e\u5728\u65e0\u7f13\u51b2\u6c34\u4e2d\u7684\u6eb6\u89e3\u5ea6\uff0c\u5982\u8868<\/span>1<\/span>\u6240\u793a\u3002\u5728<\/span>pH 8.0<\/span>\u65f6\u7684\u6eb6\u89e3\u5ea6\u6700\u4f4e\uff0c<\/span>22 mg<\/span>\u53ef\u6eb6\u4e8e<\/span>250 mlpH 8.0<\/span>\u7684\u7f13\u51b2\u6db2\u4e2d\uff1b<\/span>16 mg<\/span>\u53ef\u6eb6\u4e8e<\/span>250 ml<\/span>\u5728\u65e0\u7f13\u51b2\u6027\u8d28\u7684\u6c34\u3002\u7531\u4e8e\u6700\u9ad8\u6cbb\u7597\u5242\u91cf\u548c\u89c4\u683c\u4e3a<\/span>6 mg<\/span>\uff0c\u56e0\u6b64\u5229\u57f9\u916e\u53ef\u5f52\u7c7b\u4e3a\u9ad8\u5ea6\u53ef\u6eb6\u6027\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u5229\u57f9\u916e\u662f\u4e00\u79cd\u9ad8\u6e17\u900f\u6027\u836f\u7269\uff0c\u56e0\u6b64\uff0c\u5b83\u53ef\u88ab\u5f52\u7c7b\u4e3a<\/span>BCS I<\/span>\u7c7b\u836f\u7269\u3002\u6b64\u5206\u7c7b\u4e0e\u57fa\u4e8e<\/span>BDDCS<\/span>\u7684\u5206\u7c7b\u4e00\u81f4\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u6839\u636e<\/span>US-FDA<\/span>\u6570\u636e\u5e93\uff08\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff0c<\/span>2014<\/span>\uff09\uff0c\u5229\u57f9\u916e\u53c2\u6bd4\u5236\u5242\u4e2d\u7684\u5341\u4e8c\u70f7\u57fa\u786b\u9178\u94a0\u7684\u91cf\u5728\u8be5\u5242\u578b\u7684\u6b63\u5e38\u8303\u56f4\u5185\u3002\u5728\u4f20\u7edf\u7684<\/span>2\u00d72<\/span>\u8bbe\u8ba1\u4e2d\uff0c<\/span>1 mg<\/span>\u89c4\u683c\u7684\u7247\u5242\u4e2d\u542b\u6709<\/span>3.64 mg<\/span>\u5341\u4e8c\u70f7\u57fa\u786b\u9178\u94a0\u7684\u4eff\u5236\u836f\u5728<\/span>34<\/span>\u4f8b\u53d7\u8bd5\u8005\u4e2d\u672a\u80fd\u663e\u793a\u51fa\u751f\u7269\u7b49\u6548\u6027\uff0c\u56e0\u4e3a<\/span>Cmax<\/span>\u7684<\/span>90<\/span>\uff05<\/span>CI<\/span>\u4e3a<\/span>70.01-86.80<\/span>\uff0c<\/span>AUC<\/span>\u7684<\/span>90<\/span>\uff05<\/span>CI<\/span>\u4e3a<\/span>74.74-91.72<\/span>\u3002\u5728\u4e24\u79cd\u60c5\u51b5\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u5dee\u5f02\uff0c\u70b9\u4f30\u8ba1\u663e\u793a\u5927\u7ea6<\/span>20<\/span>\uff05\u7684\u5dee\u5f02\u3002<\/span>
<\/span><\/p>\n

\u7531\u4e8e\u53c2\u6bd4\u5236\u5242\u4e2d\u542b\u6709\u5341\u4e8c\u70f7\u57fa\u786b\u9178\u94a0\uff0c\u4f7f\u7528\u6868\u6cd5\u3001<\/span>50 rpm<\/span>\u3001<\/span>pH 1.2<\/span>\u548c<\/span>6.8<\/span>\u4ecb\u8d28\u4e2d\uff08<\/span>500 ml<\/span>\uff09\u53ef\u5728<\/span>10<\/span>\u5206\u949f\u5185\u53ef\u5b8c\u5168\u6eb6\u51fa\uff08<\/span>> 85<\/span>\uff05\uff09\u3002\u5bf9\u4e8e\u6d4b\u8bd5\u4ea7\u54c1\uff0c\u5728<\/span>7.5<\/span>\u5206\u949f\u5185\u5b8c\u5168\u6eb6\u51fa\u3002\u5728<\/span>pH 4.5<\/span>\u4ecb\u8d28\u4e2d\u6570\u636e\u672a\u4e0e\u6587\u4ef6\u4e00\u8d77\u63d0\u4ea4\uff0c\u4f46\u53ef\u4ee5\u63a8\u6d4b\u5728<\/span>pH 4.5<\/span>\u4e2d\u4f1a\u5f97\u5230\u76f8\u540c\u7684\u7ed3\u679c\uff0c\u56e0\u4e3a\u5229\u57f9\u916e\u5728<\/span>pH 6.8<\/span>\u4ecb\u8d28\u4e2d\u7684\u6eb6\u89e3\u5ea6\u6700\u4f4e\uff08\u89c1\u4e0b\u8868\uff09\u3002<\/span><\/span><\/p>\n


<\/span><\/span><\/p>\n<\/p>\n


<\/p>\n

\u603b\u4e4b\uff0c\u8be5\u5b9e\u4f8b\u8bf4\u660e\uff0c\u5c11\u91cf\u5341\u4e8c\u70f7\u57fa\u786b\u9178\u94a0\uff08<\/span>3.64 mg<\/span>\uff09\u53ef\u964d\u4f4e\u5229\u57f9\u916e\u7684\u751f\u7269\u5229\u7528\u5ea6\uff08\u5373\u4f7f\u53c2\u6bd4\u5236\u5242\u4e2d\u4e5f\u4f7f\u7528\u4e86\u5341\u4e8c\u70f7\u57fa\u786b\u9178\u94a0\uff09\uff0c\u5e76\u4e14\u8fd9\u65e0\u6cd5\u901a\u8fc7\u6bd4\u8f83\u6eb6\u51fa\u66f2\u7ebf\u800c\u68c0\u6d4b\u5230\u3002\u76f8\u53cd\uff0c\u8868\u9762\u6d3b\u6027\u5242\u6709\u5229\u4e8e\u5229\u57f9\u916e\u7684\u6da6\u6e7f\u548c\u6eb6\u51fa\uff0c\u5e76\u4f7f\u5229\u57f9\u916e\u80fd\u591f\u975e\u5e38\u8fc5\u901f\u6eb6\u51fa\u3002\u5341\u4e8c\u70f7\u57fa\u786b\u9178\u94a0\u53ef\u7528\u4e8e\u63d0\u9ad8\u6eb6\u89e3\u5ea6\u548c\u6e17\u900f\u6027\uff0c\u4f46\u5df2\u6709\u6587\u732e\u63cf\u8ff0\u5176\u5bf9\u6e17\u900f\u6027<\/span>\/<\/span>\u5438\u6536\u4ea7\u751f\u4e0d\u5229\u5f71\u54cd\uff08<\/span>Buch<\/span>\u7b49\u4eba\uff0c<\/span>2010<\/span>\uff1b<\/span>Miller<\/span>\u7b49\u4eba\uff0c<\/span>2011<\/span>\uff09\u3002\u91cd\u8981\u7684\u662f\uff0c\u8be5\u5229\u57f9\u916e\u7247\u5242\u53ef\u80fd\u5df2\u7ecf\u7533\u8bf7<\/span>BCS<\/span>\u751f\u7269\u8c41\u514d\uff0c\u56e0\u4e3a\u5b83\u53ef\u80fd\u5f52\u4e3a<\/span>BCS I<\/span>\u7c7b\u836f\u7269\uff0c\u5e76\u4e14\u6d4b\u8bd5\u548c\u53c2\u6bd4\u4ea7\u54c1\u7684\u6eb6\u51fa\u66f2\u7ebf\u90fd\u5728<\/span>15<\/span>\u5206\u949f\u5185\u663e\u793a\u5b8c\u5168\u6eb6\u51fa\u3002\u56e0\u6b64\uff0c\u4e3a\u9632\u6b62\u60a3\u8005\u4f7f\u7528\u975e\u751f\u7269\u7b49\u6548\u4ea7\u54c1\u552f\u4e00\u65b9\u6cd5\u662f\u5173\u6ce8\u5173\u952e\u7684\u8f85\u6599\uff08\u5373\u4f7f\u53ea\u542b\u5fae\u91cf\uff09\u3002<\/span><\/p>\n


<\/p>\n

\u4ee5\u4e0a\u5e76\u4e0d\u662f\u4e00\u4e2a\u5b64\u7acb\u7684\u6848\u4f8b\uff0c\u53e6\u4e00\u79cd\u542b\u6709<\/span>1.5 mg SLS<\/span>\u7684<\/span>1 mg<\/span>\u89c4\u683c\u7684\u4eff\u5236\u836f\u4e5f\u672a\u80fd\u663e\u793a\u51fa\u751f\u7269\u7b49\u6548\u6027\uff0c<\/span>Cmax<\/span>\u7684<\/span>90<\/span>\uff05<\/span>CI<\/span>\u4e3a<\/span>77.9-95.0<\/span>\uff0c<\/span>AUC<\/span>\u7684<\/span>90<\/span>\uff05<\/span>CI<\/span>\u4e3a<\/span>80.7-98.1<\/span>\uff08\u8bf7\u6ce8\u610f\uff0c\u51fa\u4e8e\u5b89\u5168\u539f\u56e0\uff0c\u5229\u57f9\u916e\u7684\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u901a\u5e38\u4ee5<\/span>1 mg<\/span>\u89c4\u683c\u8fdb\u884c\uff09\u3002\u5728\u8be5\u6848\u4f8b\u4e2d\uff0c\u8f83\u4f4e\u7684\u751f\u7269\u5229\u7528\u5ea6\u4e5f\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u8457\u6027\uff0c\u56e0\u4e3a<\/span>90<\/span>\uff05<\/span>CI<\/span>\u4e0d\u5305\u542b<\/span>100<\/span>\uff05\u503c\u3002\u76d1\u7ba1\u7ecf\u9a8c\u663e\u793a\uff0c\u4e0d\u542b\u5341\u4e8c\u70f7\u57fa\u786b\u9178\u94a0\u7684\u5229\u57f9\u916e\u4eff\u5236\u7247\u5242\u80fd\u591f\u663e\u793a\u51fa\u4e0e\u53c2\u6bd4\u4ea7\u54c1\u7684\u751f\u7269\u7b49\u6548\u6027\uff0c\u542b\u6709\u5c11\u91cf\u5341\u4e8c\u70f7\u57fa\u786b\u9178\u94a0\u7684\u4eff\u5236\u7247\u5242\u4e5f\u80fd\u591f\u663e\u793a\u51fa\u751f\u7269\u7b49\u6548\u6027\uff0c\u751a\u81f3\u542b\u6709<\/span>9 mg<\/span>\u5341\u4e8c\u70f7\u57fa\u786b\u9178\u94a0\u7684\u4eff\u5236\u7247\u5242\u4e5f\u80fd\u591f\u663e\u793a\u51fa\u751f\u7269\u7b49\u6548\u6027\u3002\u56e0\u6b64\uff0c\u4e0d\u4ec5\u5341\u4e8c\u70f7\u57fa\u786b\u9178\u94a0\u7684\u91cf\u4f1a\u5bf9\u751f\u7269\u5229\u7528\u5ea6\u4ea7\u751f\u4e0d\u5229\u5f71\u54cd\uff0c\u4e14\u4e0e\u5176\u5b83\u8f85\u6599\u7684\u76f8\u4e92\u4f5c\u7528\u4e5f\u53ef\u80fd\u4f1a\u963b\u65ad\u5341\u4e8c\u70f7\u57fa\u786b\u9178\u94a0\u7684\u4f5c\u7528\uff08\u4f8b\u5982\uff0c\u901a\u8fc7\u5438\u6536\u6216\u5438\u9644\uff09\u3002<\/span><\/p>\n


<\/p>\n

\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u5bfc\u81f4\u5229\u57f9\u916e\u751f\u7269\u5229\u7528\u5ea6\u964d\u4f4e\u7684\u673a\u5236\u3002\u6709\u53ef\u80fd\u662f\u6e17\u900f\u6027\u964d\u4f4e\uff08<\/span>Miller<\/span>\u7b49\u4eba\uff0c<\/span>2011<\/span>\uff0c<\/span>2012<\/span>\uff1b<\/span>Dahan<\/span>\u548c<\/span>Miller<\/span>\uff0c<\/span>2012<\/span>\uff09\uff0c\u80f6\u675f\u5185\u7684\u836f\u7269\u6355\u83b7\uff08\u5176\u5185\u7684\u836f\u7269\u65e0\u6cd5\u88ab\u5438\u6536\uff09\uff08<\/span>Buch<\/span>\u7b49\u4eba\uff0c<\/span>2010<\/span>\uff09\u6216\u8005\u662f\u56e0\u4e3a\u5236\u5242\u4e2d\u7684\u5341\u4e8c\u70f7\u57fa\u786b\u9178\u94a0\u964d\u4f4e\u4e86\u6eb6\u51fa\u8bd5\u9a8c\u7684\u533a\u5206\u529b\uff0c\u4ee5\u81f4\u65e0\u6cd5\u68c0\u6d4b\u5230\u4f53\u5185\u7684\u76f8\u5173\u5dee\u5f02\uff0c\u56e0\u6b64\u6ca1\u6709\u89c2\u5bdf\u5230\u8fd9\u4e9b\u5dee\u5f02\u3002<\/span><\/p>\n

EMA\u5173\u4e8e\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u7684\u6307\u5357<\/strong><\/span><\/p>\n

\u5728\u8003\u8651\u4e0a\u8ff0\u5b9e\u4f8b\u540e\uff0c\u66f4\u5bb9\u6613\u7406\u89e3\u5173\u4e8e\u8f85\u6599\u7ec4\u5408\u4ee5\u83b7\u5f97\u751f\u7269\u8c41\u514d\u7684\u4e25\u683c\u8981\u6c42\uff08\u4eba\u7528\u836f\u54c1\u59d4\u5458\u4f1a\uff0c<\/span>2010<\/span>\uff09\u3002\u57fa\u4e8e<\/span>BCS<\/span>\u7684\u751f\u7269\u8c41\u514d\u7684\u9644\u4ef6<\/span>III<\/span>\u8981\u6c42\uff0c\u53ef\u80fd\u5f71\u54cd\u751f\u7269\u5229\u7528\u5ea6\u7684\u8f85\u6599\u5e94\u5177\u6709\u76f8\u540c\u7684\u5b9a\u6027\u548c\u5b9a\u91cf\u7ec4\u6210\u3002\u5bf9\u4e8e\u5176\u5b83\u8f85\u6599\uff0c\u5176\u8981\u6c42\u53d6\u51b3\u4e8e\u836f\u7269\u7684<\/span>BCS<\/span>\u7c7b\u522b\u3002\u5bf9\u4e8e<\/span>I<\/span>\u7c7b\u836f\u7269\uff0c\u867d\u7136\u9f13\u52b1\u5b9a\u91cf\u5730\u4f7f\u7528\u76f8\u4f3c\u91cf\u7684\u76f8\u540c\u8f85\u6599\uff0c\u4f46\u4e5f\u53ef\u4ee5\u6709\u8d28\u91cf\u4e0a\u7684\u5dee\u5f02\u3002\u5bf9\u4e8e<\/span>BCS III<\/span>\u7c7b\u836f\u7269\uff0c\u8fd9\u4e9b\u975e\u5173\u952e\u6027\u8f85\u6599\u7684\u7ec4\u6210\u5fc5\u987b\u5728\u8d28\u91cf\u4e0a\u76f8\u540c\u4e14\u5728\u6570\u91cf\u4e0a\u76f8\u4f3c\uff0c\u56e0\u4e3a\u5373\u4f7f\u662f\u5e38\u89c4\u8f85\u6599\u4e5f\u53ef\u80fd\u5bf9\u6e17\u900f\u6027\u4ea7\u751f\u5f71\u54cd\uff0c\u867d\u7136\u5728\u7f16\u5199\u6307\u5357\u65f6\u53ef\u80fd\u5c1a\u4e0d\u6e05\u695a\u8fd9\u4e9b\u5f71\u54cd\u3002\u5df2\u53d1\u8868\u7684\u6587\u732e\u8bc1\u660e\u4e86\u8fd9\u4e00\u89c2\u70b9\uff0c\u7fa7\u7532\u57fa\u6dc0\u7c89\u94a0\u3001\u4f4e\u53d6\u4ee3\u7f9f\u4e19\u57fa\u7ea4\u7ef4\u7d20\u3001\u4ea4\u8054\u7fa7\u7532\u57fa\u7ea4\u7ef4\u7d20\u94a0\u3001\u7f9f\u4e19\u57fa\u7ea4\u7ef4\u7d20\u3001\u805a\u7ef4\u916e\uff08<\/span>K29\/32<\/span>\uff09\u3001\u805a\u7ef4\u916e\uff08<\/span>K90<\/span>\uff09\u3001\u786c\u8102\u9178\u9541\u3001\u5355\u786c\u8102\u9178\u7518\u6cb9\u916f\u3001\u8f6f\u8d28\u65e0\u6c34\u7845\u9178\u3001\u4e59\u57fa\u7ea4\u7ef4\u7d20\u548c\u7532\u57fa\u7ea4\u7ef4\u7d20\u5f71\u54cd\u6c34\u6eb6\u6027\u5316\u5408\u7269<\/span>5(6)-<\/span>\u7fa7\u57fa\u8367\u5149\u7d20\u7684\u819c\u6e17\u900f\u6027\uff08<\/span>Takizawa<\/span>\u7b49\u4eba\uff0c<\/span>2013<\/span>\uff09\u3002\u6b64\u5916\uff0c\u5df2\u7ecf\u6ce8\u610f\u5230\u7fa7\u7532\u57fa\u7ea4\u7ef4\u7d20\u9499\u548c\u5fae\u6676\u7ea4\u7ef4\u7d20\u80fd\u591f\u901a\u8fc7\u8c03\u8282<\/span>P-gp<\/span>\u6765\u589e\u52a0\u7532\u57fa\u6cfc\u5c3c\u677e\u9f99\u7684\u5438\u6536\uff08<\/span>Oda<\/span>\u7b49\u4eba\uff0c<\/span>2004<\/span>\uff09\u3002\u5361\u62c9\u80f6\uff08<\/span>Kalitsky-Szirtes<\/span>\u7b49\u4eba\uff0c<\/span>2004<\/span>\uff09\u3001\u6297\u574f\u8840\u9178\uff08<\/span>El-Masry<\/span>\u548c<\/span>bou-Donia<\/span>\uff0c<\/span>2003<\/span>\uff09\u548c<\/span>EDTA<\/span>\uff08<\/span>Li<\/span>\u7b49\u4eba\uff0c<\/span>2006<\/span>\uff09\u4e5f\u53ef\u4ee5\u589e\u5f3a\u836f\u7269\u7684\u5438\u6536\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u8be5\u6307\u5357\u7684\u9644\u5f55<\/span>II<\/span>\u89c4\u5b9a\u4e86\u53e3\u670d\u6eb6\u6db2\u7684\u8981\u6c42\uff0c\u5176\u4e2d\u89c4\u5b9a\u4e86\u5173\u952e\u7684\u8f85\u6599\u3002\u5176\u6307\u51fa\uff1a<\/span>\u201c<\/span>\u5982\u679c\u6d4b\u8bd5\u4ea7\u54c1\u5728\u7ed9\u836f\u65f6\u662f\u6c34\u6027\u53e3\u670d\u6eb6\u6db2\uff0c\u5e76\u4e14\u542b\u6709\u4e0e\u5df2\u6279\u51c6\u7684\u53e3\u670d\u6eb6\u6db2\u6d53\u5ea6\u76f8\u540c\u7684\u6d3b\u6027\u7269\u8d28\uff0c\u5219\u53ef\u4ee5\u514d\u9664\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u3002\u7136\u800c\uff0c\u5982\u679c\u8f85\u6599\u53ef\u80fd\u4f1a\u5f71\u54cd\u6d3b\u6027\u7269\u8d28\u7684\u80c3\u80a0\u9053\u8f6c\u8fd0\uff08\u4f8b\u5982\uff0c\u5c71\u68a8\u7cd6\u9187\u3001\u7518\u9732\u9187\u7b49\uff09\u3001\u5438\u6536\uff08\u4f8b\u5982\uff0c\u53ef\u80fd\u5f71\u54cd\u8f6c\u8fd0\u86cb\u767d\u7684\u8868\u9762\u6d3b\u6027\u5242\u6216\u8f85\u6599\uff09\u3001\u4f53\u5185\u6eb6\u89e3\u5ea6\uff08\u4f8b\u5982\uff0c\u5171\u6eb6\u5242\uff09\u6216\u4f53\u5185\u7a33\u5b9a\u6027\uff0c\u5219\u5e94\u8fdb\u884c\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\uff0c\u9664\u975e\u53ef\u901a\u8fc7\u53c2\u8003\u5176\u5b83\u6570\u636e\u53ef\u4ee5\u5145\u5206\u8bc1\u660e\u8fd9\u4e9b\u8f85\u6599\u7684\u6570\u91cf\u5dee\u5f02\u3002\u8f85\u6599\u76f8\u4f3c\u6027\u7684\u76f8\u540c\u8981\u6c42\u9002\u7528\u4e8e\u53e3\u670d\u6eb6\u6db2\u7684\u751f\u7269\u8c41\u514d\uff08\u89c1\u9644\u5f55<\/span>III<\/span>\uff0c\u7b2c<\/span>IV.2<\/span>\u8282<\/span>\u201c<\/span>\u8f85\u6599<\/span>\u201d<\/span>\uff09\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u4e2a\u6587\u672c\u53ef\u88ab\u8ba4\u4e3a\u662f\u6a21\u68f1\u4e24\u53ef\u7684\uff0c\u56e0\u4e3a\u53c2\u8003\u5176\u5b83\u6570\u636e\u7684\u7406\u7531\u4f3c\u4e4e\u662f\u53ef\u80fd\u7684\uff0c\u800c\u5bf9\u4e8e\u57fa\u4e8e<\/span>BCS<\/span>\u7684\u751f\u7269\u8c41\u514d\u7684\u4e25\u683c\u8981\u6c42\u4f3c\u4e4e\u662f\u9002\u7528\u7684\uff0c\u5982\u4e0a\u6240\u8ff0\uff0c\u6ca1\u6709\u4efb\u4f55\u7406\u7531\u53ef\u63a5\u53d7\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u79cd\u6a21\u68f1\u4e24\u53ef\uff0c\u6216\u8005\u8bf4\u8fd9\u53ea\u662f\u7533\u8bf7\u4eba\u5728\u5408\u7406\u65f6\u53ef\u4ee5\u504f\u79bb\u7684\u6307\u5bfc\u539f\u5219\u8fd9\u4e00\u4e8b\u5b9e\uff0c\u9f13\u52b1\u4eff\u5236\u836f\u516c\u53f8\u4e0d\u65ad\u5c1d\u8bd5\u8bc1\u660e\u6d4b\u8bd5\u4ea7\u54c1\u4e0e\u53c2\u6bd4\u5236\u5242\u5728\u5173\u952e\u8f85\u6599\uff08\u4e3b\u8981\u662f\u5c71\u68a8\u7cd6\u9187\uff09\u65b9\u9762\u7684\u5dee\u5f02\uff08<\/span>Chen<\/span>\u7b49\u4eba\uff0c<\/span>2006<\/span>\uff09\u3002\u7531\u4e8e\u6b27\u76df\u76ee\u524d\u7531<\/span>28<\/span>\u4e2a\u56fd\u5bb6\uff08\u52a0\u4e0a\u53e6\u5916\u4e09\u4e2a\u6b27\u6d32\u7ecf\u6d4e\u533a\u56fd\u5bb6\uff09\u7ec4\u6210\uff0c\u56e0\u6b64\u5f88\u5bb9\u6613\u627e\u5230\u4e00\u4e2a\u80fd\u591f\u63a5\u53d7\u8fd9\u4e9b\u5dee\u5f02\u7684\u56fd\u5bb6\uff0c\u800c\u5176\u4ed6\u56fd\u5bb6\u5219\u66f4\u613f\u610f\u9075\u5faa\u8be5\u6307\u5357\u3002\u56e0\u6b64\uff0c\u8bb8\u591a\u4ef2\u88c1\u6848\u4ef6\u90fd\u6700\u7ec8\u5728<\/span>CHMP<\/span>\u88c1\u51b3\u3002<\/span>
<\/p>\n

\u867d\u6709\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u6307\u5357\u7684\u5efa\u8bae\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u5de5\u4f5c\u7ec4\u5173\u4e8e\u5c71\u68a8\u9187\u5bf9\u9ad8\u6e17\u900f\u6027\u836f\u7269\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u5f71\u54cd\u7684\u5177\u4f53\u95ee\u7b54\uff0c\u4f46<\/span>CHMP<\/span>\u4ecd\u63a5\u53d7\u4e86\u7533\u8bf7\u4eba\u5728\u6b64\u95ee\u9898\u4e0a\u63d0\u51fa\u7684\u7406\u7531\u3002\u8be5\u95ee\u7b54\u8bb0\u5f55\u6307\u51fa<\/span>\u201c<\/span>\u5728\u4eff\u5236\u836f\u7533\u8bf7\u7684\u5f00\u53d1\u548c\u8bc4\u4f30\u4e2d\uff0c\u5efa\u8bae\u4e25\u683c\u9075\u5b88<\/span>BE<\/span>\u6307\u5357<\/span>\u201d<\/span>\uff0c\u56e0\u4e3a\u5c71\u68a8\u9187\u7684\u5f71\u54cd\u4e0d\u4ec5\u9650\u4e8e\u6e17\u900f\u4f5c\u7528\uff0c\u52a0\u901f\u80a0\u9053\u8fd0\u8f93\u548c\u589e\u52a0\u80a0\u9053\u6c34\u542b\u91cf\uff08\u7531\u5927\u91cf\u5c71\u68a8\u9187\uff08\u5728<\/span>II<\/span>\u7c7b\u836f\u7269\u4e2d<\/span>> 1.25 g<\/span>\uff0c\u5728<\/span>I<\/span>\u7c7b\u836f\u7269<\/span>> 5 g<\/span>\uff09\u5f15\u8d77\uff09\uff0c\u8fd8\u5bf9\u4e00\u4e2a\u663e\u8457\u7684\u4e9a\u7fa4\uff08\u62db\u52df\u7ea6<\/span>30<\/span>\u4f8b\u53d7\u8bd5\u8005\u7684\u4e00\u4e9b\u7814\u7a76\u4e2d\u7684<\/span>P2<\/span>\u53d7\u8bd5\u8005\uff09\u4ea7\u751f\u4e0d\u8010\u53d7\u5f71\u54cd\uff0c\u8fd9\u53ef\u53d1\u751f\u5728\u4ec5\u51e0\u6beb\u514b\u8f85\u6599\u7ed9\u836f\u540e\u3002<\/span> <\/span><\/p>\n

—-END—-<\/span><\/p>\n


<\/p>\n

\n


<\/p>\n

\u6392\u7248\uff1aSUNRISE<\/span>
<\/p>\n

\n
\n
\n
\u5e7f\u800c\u544a\u4e4b<\/section>\n<\/section>\n<\/section>\n
\n
\n

\u2299 \u540c\u5199\u610f\u57f9\u8bad<\/span><\/p>\n

\u5199\u610f\u8bba\u575b\u4e28\u65b0\u836f\u4e2d\u7f8e\u53cc\u62a5\u4e4b\u5236\u5242\u6eb6\u51fa\u6280\u672f\u5f00\u53d1<\/a><\/span><\/p>\n

\u5199\u610f\u8bba\u575b\u4e28\u56fd\u9645\u89c4\u8303\u4e0b\u751f\u7269\u836f\u5168\u751f\u547d\u5468\u671f\u8d28\u91cf\u7ba1\u7406<\/a><\/span><\/p>\n

\u5199\u610f\u516c\u76ca\u4e28\u4eff\u5236\u836f\u4e00\u81f4\u6027\u8bc4\u4ef7\u5927\u76d8\u70b9\u4e0e\u603b\u51b3\u6218<\/span><\/a><\/p>\n

\u6ee1\u8db3IND\/NDA\u4e2d\u7f8e\u53cc\u62a5\u7684\u53e3\u670d\u65b0\u836f\u5236\u5242\u7814\u53d1<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\n

\"\u7f8e\u56fd\u4e0e\u6b27\u76df\u5bf9API\u4e0e\u8f85\u6599\u76f8\u4e92\u4f5c\u7528\u5f71\u54cdBE\u770b\u6cd5\"<\/p>\n

\u836f\u4e8b\u7eb5\u6a2a\u662f\u4e00\u4e2a\u5f00\u653e\uff0c\u7531\u81ea\u613f\u8005\u7ec4\u6210\u7684\u56e2\u4f53\uff0c\u73b0\u6709\u6210\u545838\u540d\uff0c\u5206\u522b\u4e3aVoyager88\uff08\u9b4f\u5229\u519b\uff09\uff0c\u96f7\u8bfa\u5c9b\uff0c\u4e09\u5206\u8bdd\uff0cHerman\uff0c\u6885\u5e0c\uff0c\u6587\u7af9\uff0cduke\uff0cyhqqqqq\uff0c\u5360\u5c0f\u5175\uff0c\u98ce\u4e00\u6837\u7684\u5c4e\u58f3\u90ce\uff0c\u9526\u5fc3\u7ee3\u53e3\uff0cflydp511\uff0c\u5de7\u5de7\uff0c\u4e91\u6c34\u9053\u4eba\uff0c\u9621\u4e0a\u964c\u964c\uff0c\u591a\u5df4\u80fa\uff0c\u745c\u513f\uff0cKailyn\uff0cSmall fish\uff0c\u5b50\u708e\uff0c\u514b\u683c\u83ab\uff0cVicky\uff0cPandada\uff0c\u83ab\u5306\u5306\uff0cSophia \uff0c\u4f9d\u7136\u7279\u96f7\u897f\uff0c\u5076\u9635\u96e8\uff0cAimee\uff0c\u4ed6\u5c71\u4e4b\u77f3\uff0c\u5510\u5c0f\u7396\uff0c\u96f6\u4e0b274\u2103\uff0cGloria\uff0cBreathless\uff0cLuffy\uff0c\u80e1\u4e0d\u559c\uff0c Helen\uff0c\u843d\u843d\uff0cSUNRISE\u3002\u6b22\u8fce\u6709\u5fd7\u4e4b\u58eb\u52a0\u5165\u6211\u4eec\u56e2\u961f\u3002\u6295\u7a3f\u3001\u5408\u4f5c\u3001\u52a0\u4e13\u4e1a\u7fa4\u8bf7\u52a0\u5fae\u4fe1442015666\uff0c\u836f\u4e8b\u7eb5\u6a2a\u4e8c\u5343\u4ebaQQ\u7fa422711855\u3002<\/span>
<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u836f\u4e8b\u7eb5\u6a2a <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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