{"id":20318,"date":"2018-07-30T01:00:00","date_gmt":"2018-08-08T01:17:59","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/08\/%e5%85%b3%e4%ba%8endma%e9%99%90%e5%80%bc%e8%ae%a1%e7%ae%97\/"},"modified":"2018-08-08T09:18:02","modified_gmt":"2018-08-08T01:18:02","slug":"%e5%85%b3%e4%ba%8endma%e9%99%90%e5%80%bc%e8%ae%a1%e7%ae%97","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/20318\/","title":{"rendered":"\u5173\u4e8eNDMA\u9650\u503c\u8ba1\u7b97"},"content":{"rendered":"
\n

\u7ffb\u8bd1\uff1a JULIA \u6765\u6e90\uff1aJulia\u6cd5\u89c4\u7ffb\u8bd1 <\/span><\/p>\n


<\/span><\/p>\n

\u6709\u7ae5\u978b\u95ee\u5230\u4e86\u5173\u4e8eNDMA<\/span>\u9650\u503c\u7684\u8ba1\u7b97\uff0c\u4f5c\u4e3a\u975e\u4e13\u4e1a\u4eba\u58eb\uff0c\u4ee5\u4e0b\u6982\u8ff0\u4e00\u4e8c\u4ec5\u4f9b\u975e\u4e13\u4e1a\u4eba\u58eb\u5403\u74dc\u7528\uff0c\u4e13\u4e1a\u4eba\u58eb\u8bf7\u7ed5\u884c\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

NDMA<\/span><\/strong>\u57fa\u672c\u4fe1\u606f\uff1a<\/span><\/strong><\/span><\/p>\n

\u4e2d\u6587\u540d\uff1a<\/span>N-<\/span>\u4e8c\u7532\u57fa\u4e9a\u785d\u80fa<\/span><\/span><\/p>\n

\u82f1\u6587\u540d\uff1a<\/span>N-Nitrosodimethylamine<\/span><\/span><\/p>\n

CAS<\/span>\u53f7\uff1a<\/span>62-75-9<\/span><\/span><\/p>\n

\u5206\u5b50\u5f0f\uff1a<\/span>C2<\/sub>H6<\/sub>N2<\/sub>O<\/span><\/span><\/p>\n

\u5206\u5b50\u91cf\uff1a<\/span>74.08<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u6309<\/span><\/strong>ICH-M7<\/span><\/strong>\u8ba1\u7b97\uff08\u6750\u6599\u548c\u5de5\u5177\uff1a\u7f51\u7edc<\/span><\/strong>+<\/span><\/strong>\u7535\u8111<\/span><\/strong>+<\/span><\/strong>\u4eba\u8111+\u56fd\u5916\u514d\u8d39\u6570\u636e\u5e93\uff09<\/span><\/strong><\/span><\/p>\n

\u4ee5\u4e0b<\/span>ICH<\/span>\u6240\u6458\u5f15\u5185\u5bb9\u6765\u81ea<\/span>ICH M7<\/span>\u6b63\u6587\uff0c\u7248\u672c<\/span>ICH M7(R1)<\/span>\uff0c\u53d1\u5e03\u65f6\u95f4<\/span>2017<\/span>\u5e74<\/span>3<\/span>\u6708<\/span>31<\/span>\u65e5\uff08<\/span>ICH<\/span>\u5b98\u65b9<\/span>M7<\/span>\u6b63\u6587\u4e0b\u8f7d\u94fe\u63a5<\/span>http:\/\/www.ich.org\/fileadmin\/Public_Web_Site\/ICH_Products\/Guidelines\/Multidisciplinary\/M7\/M7_R1_Addendum_Step_4_2017_0331.pdf<\/span>\uff09<\/span><\/span><\/p>\n

\u7b2c<\/span>16<\/span>\u9875\u5728<\/span>9.2<\/span>\u6b63\u6587\u7ed3\u675f\u4e4b\u540e\u7684\u6ce8\uff08<\/span>Note<\/span>\uff09\u91cc\u6ce8<\/span>4<\/span>\u4ece<\/span>TD50<\/sub><\/span>\u7ebf\u6027\u5916\u63a8\u4e3e\u4f8b\uff08<\/span>Example of linear extrapolation from the TD50<\/sub><\/span>\uff09\u91cc\u7ed9\u51fa\u7684\u8ba1\u7b97\u4e3e\u4f8b<\/span><\/span><\/p>\n

————————<\/span>\u5f15\u7528\u5f00\u59cb<\/span><\/span><\/p>\n

Note 4 Example of linear extrapolation from the TD50<\/sub><\/span><\/span><\/p>\n

It is possible to calculate a compound-specific acceptable intake based on rodent carcinogenicity potency data such as TD50<\/sub> values (doses giving a 50% tumor incidence equivalent to a cancer risk probability level of 1:2). Linear extrapolation to a probability of 1 in 100,000 (i.e., the accepted life time risk level used) is achieved by simply dividing the TD50 by 50,000. This procedure is similar to that employed for derivation of the TTC.<\/span><\/p>\n

\u8bd1\u6587\uff1a\u53ef\u4ee5\u6839\u636e\u556e\u9f7f\u52a8\u7269\u81f4\u764c\u6548\u5e94\u6570\u636e\uff0c\u4f8b\u5982<\/span>TD50<\/sub><\/span>\u503c\uff08\u5bfc\u81f4<\/span>50%<\/span>\u80bf\u7624\u53d1\u751f\u7387\u7684\u7ed9\u836f\u5242\u91cf\u76f8\u5f53\u4e8e\u60a3\u764c\u98ce\u9669\u53ef\u80fd\u6027\u6c34\u5e73\u4e3a<\/span>1<\/span>\uff1a<\/span>2<\/span>\uff09\u8ba1\u7b97\u5316\u5408\u7269\u7684\u53ef\u63a5\u53d7\u6444\u5165\u503c\u3002\u7ebf\u6027\u5916\u63a8\u81f3\u53ef\u80fd\u6027\u4e3a\u5341\u4e07\u5206\u4e4b\u4e00\uff08\u5373\uff0c\u6240\u7528\u7684\u5df2\u63a5\u53d7\u7684\u751f\u547d\u5468\u671f\u98ce\u9669\u6c34\u5e73\uff09\uff0c\u7b80\u5355\u91c7\u7528<\/span>TD50<\/span>\u503c\u9664\u4ee5\u4e94\u4e07\uff08<\/span>50,000<\/span>\uff09\u3002\u8be5\u65b9\u6cd5\u7c7b\u4f3c\u4e8e<\/span>TTC<\/span>\u8ba1\u7b97\u65b9\u6cd5\u3002<\/span><\/span><\/p>\n

Calculation example: Ethylene oxide<\/span><\/p>\n

TD50 values for ethylene oxide according to the Carcinogenic Potency Database are 21.3 mg\/kgbody weight\/day (rat) and 63.7 mg\/kg body weight\/day (mouse). For the calculation of an acceptable intake, the lower (i.e., more conservative) value of the rat is used.<\/span><\/p>\n

To derive a dose to cause tumors in 1 in 100,000 animals, divide by 50,000: 21.3 mg\/kg\u00f750,000 = 0.42\u03bcg\/kg<\/span><\/p>\n

To derive a total human daily dose: 0.42 \u03bcg\/kg\/day x 50 kg body weight = 21.3 \u03bcg\/person\/day<\/span><\/p>\n

Hence, a dailylife-long intake of 21.3 \u03bcg ethylene oxide would correspond to a theoretical cancer risk of 10-5 and therefore be an acceptable intake when present as an impurity in a drug substance.<\/span><\/p>\n

\u8ba1\u7b97\u4e3e\u4f8b\uff1a\u73af\u6c27\u4e59\u70f7<\/span><\/p>\n

\u6839\u636e\u81f4\u764c\u6548\u5e94\u6570\u636e\u5e93\uff0c\u73af\u6c27\u4e59\u70f7\u7684<\/span>TD50<\/span>\u4e3a<\/span>21.3mg\/kg<\/span>\u4f53\u91cd<\/span>\/<\/span>\u5929\uff08\u5927\u9f20\uff09\u548c<\/span>63.7mg\/kg<\/span>\u4f53\u91cd<\/span>\/<\/span>\u5929\uff08\u5c0f\u9f20\uff09\u3002\u5728\u8ba1\u7b97\u53ef\u63a5\u53d7\u6444\u5165\u91cf\u65f6\uff0c\u91c7\u7528\u4e86\u8f83\u4f4e\u7684\u5927\u9f20\u503c\uff08\u5373\u66f4\u4fdd\u5b88\uff09\u3002<\/span><\/span><\/p>\n

\u8ba1\u7b97\u5341\u4e07\u5206\u4e4b\u4e00\u6982\u7387\u81f4\u764c\u5242\u91cf\uff0c\u5c06\u8be5\u503c\u9664\u4ee5<\/span>50,000<\/span>\uff1a<\/span>21.3mg\/kg\u00f750,000= 0.42\u03bcg\/kg.<\/span><\/span><\/p>\n

\u8ba1\u7b97\u4eba\u7c7b\u6bcf\u65e5\u603b\u6444\u5165\u91cf\uff1a<\/span>0.42\u03bcg\/kg\u00d750kg<\/span>\u4f53\u91cd<\/span> = 21.3\u03bcg\/<\/span>\u4eba<\/span>\/<\/span>\u5929\u3002<\/span><\/span><\/p>\n

\u56e0\u6b64\uff0c\u6c38\u4e45\u6027\u6bcf\u65e5\u670d\u7528<\/span>21.3\u03bcg<\/span>\u73af\u6c27\u4e59\u70f7\u5bf9\u5e94\u7406\u8bba\u81f4\u764c\u98ce\u9669\u4e3a\u5341\u4e07\u5206\u4e4b\u4e00\u662f\u73af\u6c27\u4e59\u70f7\u4f5c\u4e3a\u836f\u54c1\u4e2d\u7684\u6742\u8d28\u65f6\u53ef\u63a5\u53d7\u7684\u6444\u5165\u503c\u3002<\/span><\/span><\/p>\n

——————<\/span>\u5f15\u7528\u5b8c<\/span><\/span><\/p>\n

\u5728<\/span>TOXNET<\/span>\u6570\u636e\u5e93\u67e5\u5f97\u81f4\u764c\u76f8\u5173\u6570\u636e<\/span><\/span><\/p>\n

https:\/\/toxnet.nlm.nih.gov\/cpdb\/chempages\/N-NITROSODIMETHYLAMINE.html
<\/span><\/p>\n

\"\u5173\u4e8eNDMA\u9650\u503c\u8ba1\u7b97\"<\/p>\n


<\/span><\/p>\n

\u5927\u9f20\u548c\u5c0f\u9f20\u6570\u636e\u5206\u522b\u4e3a<\/span>0.0959mg\/kg\/day<\/span>\u548c<\/span>0.189mg\/kg\/day<\/span>\uff0c\u6309\u4e0a\u8ff0\u8ba1\u7b97\uff1a<\/span><\/span><\/p>\n

\u5927\u9f20\u6570\u636e\u5916\u63a8\uff1a<\/span>0.0959mg<\/span>\/kg\u00f750,000\u00d750kg<\/span>\u4f53\u91cd<\/span>=0.001918\u03bcg\/kg\u00d750kg<\/span>\u4f53\u91cd<\/span>= 0.0959\u03bcg\/<\/span>\u4eba<\/span>\/<\/span>\u5929<\/span><\/span><\/p>\n

\u4ee5\u7f2c\u6c99\u5766\u6bcf\u65e5\u6700\u5927\u7ed9\u836f\u5242\u91cf<\/span>320mg<\/span>\u4e3a\u4f8b\uff0c\u7f2c\u6c99\u5766<\/span>API<\/span>\u4e2d\u5141\u8bb8<\/span>NDMA<\/span>\u542b\u91cf\u4e3a\uff1a<\/span><\/span><\/p>\n

0.0959 \u03bcg\u00f7320mg = 0.0003\u03bcg\/mg =0.3ppm<\/span><\/p>\n

\u5c0f\u9f20\u6570\u636e\u540c\u7406\u5916\u63a8\u5f97\u5230\u7ed3\u679c\u4e3a\uff1a<\/span>
<\/span><\/span><\/p>\n

0.189mg<\/span>\/kg\u00f750,000\u00d750kg\u00f7320mg=0.00059\u03bcg\/mg=0.6ppm<\/span><\/p>\n

\u53d6\u5c0f\u4e0d\u53d6\u5927\uff08\u5b89\u5168\u8d77\u89c1\uff09\u6765\u8bf4\uff0c\u5c31\u662f\u53d6<\/span>0.3ppm<\/span>\u4e86\uff0c\u5927\u6982\u4f4e\u4e8e\u8fd9\u4e2a\u9650\u5ea6\u4e5f\u5c31\u662f\u5b89\u5168\u7684\u4e86\u3002<\/span><\/span><\/p>\n

\u8fd9\u4e2a\u9650\u5ea6\u770b\u8d77\u6765\u662f\u86ee\u4f4e\u7684\u5662\uff01\u4e0d\u8fc7\u7ae5\u978b\u4eec\u8981\u8ba1\u7b97\u81ea\u5df1\u516c\u53f8\u7684\u9650\u5ea6\uff0c\u8fd8\u8981\u7efc\u5408\u8003\u8651\u5236\u5242\u6700\u5927\u65e5\u7ed9\u836f\u91cf\u548c\u7ed9\u836f\u9014\u5f84\u7684\u3002<\/span><\/p>\n

—-<\/span><\/strong>\u4ee5\u4e0b\u518d\u8bb2<\/span><\/strong>WHO<\/span><\/strong>\u7684<\/span><\/strong>IARC\uff08\u6750\u6599\u548c\u5de5\u5177\uff1a\u7f51\u7edc<\/span><\/strong>+<\/span><\/strong>\u7535\u8111<\/span><\/strong>+<\/span><\/strong>\u4eba\u8111\uff09<\/span><\/strong>—-<\/span><\/strong><\/span><\/p>\n

\u6211\u4eec\u518d\u6765\u770b\u770b<\/span>EMA<\/span>\u4e00\u518d\u63d0\u5230\u7684<\/span>WHO IARC<\/span>\u6570\u636e\uff0c\u4e0d\u7528\u8bf4\uff0c\u81ea\u7136\u662f\u5148\u4e0a\u7f51\u67e5\u6570\u636e\u3002<\/span><\/span><\/p>\n

\u5148\u5728<\/span>IARC<\/span>\u67e5\u8be2\uff08<\/span>IARC<\/span>\u9996\u9875\u54c8<\/span>http:\/\/www.iarc.fr\/<\/span>\uff09\uff0c\u6709\u8010\u5fc3\u7684\u7ae5\u978b\u53ef\u4ee5\u4ece\u9996\u9875\u4e00\u6b65\u6b65\u67e5\u8fdb\u53bb\uff0c\u6ca1\u8010\u5fc3\u7684\u7ae5\u978b\u53ef\u4ee5\u76f4\u63a5\u8df3\u5230<\/span>https:\/\/monographs.iarc.fr\/iarc-monographs-on-the-evaluation-of-carcinogenic-risks-to-humans\/<\/span>\uff0c\u8fd9\u662f<\/span>WHO<\/span>\u7684<\/span>IARC<\/span>\u4eba\u4f53\u81f4\u764c\u98ce\u9669\u8bc4\u4f30\u5404\u8bba\uff0c\u5de6\u4fa7\u770b\u5230\u5206\u5377\u5728\u7ebf\u68c0\u7d22\uff0c\u53f3\u4fa7\u5219\u662f\u5177\u4f53\u7269\u8d28\u7684\u76ee\u5f55\u548c\u94fe\u63a5\u3002\u55ef\uff0c\u8fd9\u4e2a\u5185\u5bb9\u53ef\u4ee5\u8bf4\u662f\u76f8\u5f53\u6ef4\u591a\uff0c\u6211\u4eec\u76f4\u63a5\u8fdb\u4ea4\u53c9\u7d22\u5f15\u627e\u6211\u4eec\u8981\u7684<\/span>NDMA<\/span>\u5427\uff0c\u5c31\u662f\u8fd9\u4e2a<\/span><\/span><\/p>\n

\"\u5173\u4e8eNDMA\u9650\u503c\u8ba1\u7b97\"<\/p>\n


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<\/p>\n

\u76f4\u94fe<\/span>https:\/\/monographs.iarc.fr\/wp-content\/uploads\/2018\/07\/cumulative-cross-index.pdf<\/span>\uff0c\u8fd9\u662f<\/span>WHO<\/span>\u7684<\/span>IARC<\/span>\u5404\u8bba\u7d2f\u79ef\u4ea4\u53c9\u7d22\u5f15\uff0c\u5728\u91cc\u9762\u76f4\u63a5\u68c0\u7d22\uff08\u5982\u679c\u4f60\u7684\u7f51\u9875\u4e0d\u80fd\u76f4\u63a5\u68c0\u7d22<\/span>PDF<\/span>\u53ef\u4e0b\u8f7d\u540e\u518d\u68c0\u7d22\uff09<\/span>N-Nitrosodimethylamine<\/span>\uff0c\u5728\u7b2c<\/span>23<\/span>\u9875\u5c31\u627e\u5230\u4e86<\/span><\/span><\/p>\n

\"\u5173\u4e8eNDMA\u9650\u503c\u8ba1\u7b97\"<\/p>\n


<\/p>\n

\u8868\u793a<\/span>1972<\/span>\u5e74\u7b2c<\/span>1<\/span>\u5377\uff0c<\/span>1978<\/span>\u5e74\u7b2c<\/span>17<\/span>\u5377\u548c<\/span>1987<\/span>\u5e74\u589e\u8865<\/span>7<\/span>\u91cc\u90fd\u6709\u5b83\u7684\u4fe1\u606f\uff0c\u56de\u6765\uff08\u6d4f\u89c8\u5668\u9000\u56de\uff09\u524d\u4e00\u9875\u76ee\u5f55\u6211\u4eec\u518d\u6765\u4e0b\u8f7d\u76f8\u5173\u7684\u5377\u3002<\/span><\/span><\/p>\n

\u5728\u6b64\u4e0b\u8f7d\u7b2c<\/span>1<\/span>\u5377<\/span>https:\/\/monographs.iarc.fr\/wp-content\/uploads\/2018\/06\/mono1.pdf<\/span><\/span><\/p>\n

\u5728\u6b64\u4e0b\u8f7d\u7b2c<\/span>17<\/span>\u5377<\/span>https:\/\/monographs.iarc.fr\/wp-content\/uploads\/2018\/06\/mono17.pdf<\/span><\/span><\/p>\n

\u5728\u6b64\u4e0b\u8f7d\u589e\u8865<\/span>7 https:\/\/monographs.iarc.fr\/wp-content\/uploads\/2018\/06\/Suppl7.pdf<\/span><\/span><\/p>\n

\u4ee5\u4e0b\u662f\u5377<\/span>1<\/span>\u7684\u5c01\u9762\u6837\u5b50\uff0c\u770b\u8d77\u6765\u597d\u53e4\u8001\u54e6\uff08<\/span>NDMA<\/span>\u5728\u7b2c<\/span>95-106<\/span>\u9875\uff09<\/span><\/span><\/p>\n

\"\u5173\u4e8eNDMA\u9650\u503c\u8ba1\u7b97\"<\/p>\n


<\/p>\n

\u4ee5\u4e0b\u662f\u5377<\/span>17<\/span>\u7684\u5c01\u9762\u6837\u5b50\uff08<\/span>NDMA<\/span>\u5728\u7b2c<\/span>120-170<\/span>\u9875\uff09<\/span><\/span><\/p>\n

\"\u5173\u4e8eNDMA\u9650\u503c\u8ba1\u7b97\"<\/p>\n


<\/p>\n

\u8fd9\u662f\u589e\u8865<\/span>7<\/span>\u7684\u5c01\u9762\u6837\u5b50\uff08\u7b2c<\/span>67<\/span>\u9875\uff0c\u7ed3\u679c\u548c\u7ed3\u8bba\u4e2d\u5c06<\/span>NDMA<\/span>\u5f52\u4e3a<\/span>2A<\/span>\u7c7b\uff0c\u5373\u53ef\u80fd\u7684\u4eba\u4f53\u81f4\u764c\u7269\uff09<\/span><\/span><\/p>\n

\"\u5173\u4e8eNDMA\u9650\u503c\u8ba1\u7b97\"<\/p>\n


<\/p>\n

\uff08\u52a8\u7269\u81f4\u764c\u8bc1\u636e\u5145\u5206\uff0c\u4eba\u4f53\u81f4\u764c\u672a\u8bc1\u660e\uff09<\/span><\/p>\n

\n


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\u5e78\u8fd0\u7684\u662f\uff0c\u8fd9\u4e09\u672c\u91cc\u9762\u90fd\u662f\u53ef\u7535\u5b50\u68c0\u7d22\u6216\u8005\u5de6\u4fa7\u6709<\/span>PDF<\/span>\u4e66\u7b7e\u53ef\u4ee5\u7528\u7684\u54e6\uff0c\u5728<\/span>PDF<\/span>\u91cc\u6253\u5f00\u540e\u5229\u7528\u5b83\u7684\u67e5\u627e\u529f\u80fd\u5c31\u80fd\u627e\u5230\u6211\u4eec\u8981\u7684<\/span>N-Nitrosodimethylamine<\/span>\u6761\u76ee\uff0c\u6216\u8005\u5728\u5de6\u4fa7\u4e66\u7b7e\u627e\u5230\uff0c\u4e0d\u8fc7\u5c31\u662f\u5185\u5bb9\u6709\u70b9\u6f2b\u957f\uff0c\u5728\u5b83\u7684\u7ed3\u5c3e\u90fd\u4f1a\u6709\u4e00\u4e2a\u7efc\u8ff0\uff0c\u6570\u636e\u6bd4\u8f83\u591a\uff0c\u5927\u5bb6\u6162\u6162\u770b\u6162\u6162\u7422\u78e8\uff0c\u627e\u5230\u81ea\u5df1\u8981\u7684\u4e1c\u4e1c\u5c31\u5bf9\u4e86\u3002<\/span><\/span><\/p>\n


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\"\u5173\u4e8eNDMA\u9650\u503c\u8ba1\u7b97\"<\/p>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u84b2\u516c\u82f1 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u7ffb\u8bd1\uff1a JULIA \u6765\u6e90\uff1aJulia\u6cd5\u89c4\u7ffb\u8bd1  \u6709\u7ae5\u978b\u95ee\u5230\u4e86\u5173\u4e8eNDMA\u9650\u503c\u7684\u8ba1\u7b97\uff0c\u4f5c\u4e3a\u975e […]<\/p>\n","protected":false},"author":1,"featured_media":20319,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/20318"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=20318"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/20318\/revisions"}],"predecessor-version":[{"id":20332,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/20318\/revisions\/20332"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/20319"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=20318"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=20318"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=20318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}