{"id":22750,"date":"2018-08-07T01:00:00","date_gmt":"2018-08-09T03:16:53","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/car-t%e7%9a%84%e6%b1%9f%e6%b9%96-%e3%80%90%e8%8d%af%e7%89%a9%e7%ae%80%e8%ae%af20180807%e3%80%91\/"},"modified":"2018-08-09T11:16:59","modified_gmt":"2018-08-09T03:16:59","slug":"car-t%e7%9a%84%e6%b1%9f%e6%b9%96-%e3%80%90%e8%8d%af%e7%89%a9%e7%ae%80%e8%ae%af20180807%e3%80%91","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/22750\/","title":{"rendered":"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><br  \/><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress3-1533784614.jpg\" alt=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\" title=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\"  \/><\/p>\n<p><br  \/><\/p>\n<p><span style=\"color: rgb(216, 79, 169);\"><strong>\u4e00.\u5168\u7403\u9996\u6b3e\u4e0a\u5e02CAR-T:<\/strong><\/span><\/p>\n<p><strong style=\"color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);\"><br  \/><\/strong><\/p>\n<p><span style=\"color: rgb(216, 79, 169);\"><strong style=\"color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);\">1.Tisagenlecleuce<\/strong><strong style=\"color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);\">l<\/strong><\/span><span style=\"color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;background-color: rgb(255, 255, 255);\">, marketed as&nbsp;<\/span><span style=\"color: rgb(216, 79, 169);\"><strong style=\"color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);\">Kymriah<\/strong><\/span><strong style=\"color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);\">.<\/strong><\/p>\n<p><strong style=\"color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);\"><br  \/><\/strong><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533784614.jpg\" alt=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\" title=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\"  \/><\/p>\n<p><strong style=\"color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);\"><span style=\"color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;background-color: rgb(255, 255, 255);\"><\/span><\/strong><br  \/><\/p>\n<p><strong>2.It was invented and initially developed at the&nbsp;University of Pennsylvania;&nbsp;Novartis&nbsp;completed development, obtained FDA approval, and markets the treatment.&nbsp;In August 30 2017, it became the first FDA-approved treatment that included a&nbsp;gene therapy&nbsp;step in the United States.<\/strong><\/p>\n<p><br  \/><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress6-1533784615.jpg\" alt=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\" title=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\"  \/><\/p>\n<p style=\"box-sizing: border-box;margin-top: 1em;margin-bottom: 1em;color: rgb(51, 51, 51);\">The FDA approved Kymriah (tisagenlecleucel) for certain pediatric and young adult patients with a form of acute lymphoblastic leukemia (ALL).<\/p>\n<p style=\"box-sizing: border-box;margin-top: 1em;margin-bottom: 1em;color: rgb(51, 51, 51);\"><img class=\"\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress4-1533784615.jpg\" alt=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\" title=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\"  \/><\/p>\n<p style=\"box-sizing: border-box;margin-top: 1em;margin-bottom: 1em;color: rgb(51, 51, 51);\">\u201cWe\u2019re entering a new frontier in medical innovation with the ability to reprogram a patient\u2019s own cells to attack a deadly cancer,\u201d said FDA Commissioner Scott Gottlieb, M.D. \u201cNew technologies such as gene and cell therapies hold out the potential to transform medicine and create an inflection point in our ability to treat and even cure many intractable illnesses. At the FDA, we\u2019re committed to helping expedite the development and review of groundbreaking treatments that have the potential to be life-saving.\u201d<\/p>\n<p style=\"box-sizing: border-box;margin-top: 1em;margin-bottom: 1em;color: rgb(51, 51, 51);\">Kymriah, a cell-based gene therapy, is approved in the United States for the treatment of patients up to 25 years of age with B-cell precursor ALL that is refractory or in second or later relapse.<\/p>\n<p><strong>3.&nbsp;What is the KYMRIAH therapy process?<\/strong><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533784615.jpg\" alt=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\" title=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\"  \/><\/p>\n<p><br  \/><\/p>\n<p><strong>4.<span style=\"font-size: 16px;\">What makes KYMRIAH different from other therapies?<\/span><\/strong><\/p>\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<ul style=\"\" class=\"list-paddingleft-2\">\n<li>\n<p>KYMRIAH is a one-time treatment unlike other treatments delivered more than once<\/p>\n<\/li>\n<li>\n<p>KYMRIAH targets only your B cells rather than all of your body\u2019s cells<\/p>\n<\/li>\n<li>\n<p>KYMRIAH&nbsp;uses a short course (4 days) of chemotherapy to prepare your body for infusion<\/p>\n<\/li>\n<li>\n<p>Even if you aren\u2019t in remission, you can start KYMRIAH therapy<\/p>\n<\/li>\n<li>\n<p>Because KYMRIAH uses your own cells, you do not need a donor<\/p>\n<\/li>\n<\/ul>\n<p><strong style=\"color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);\"><span style=\"color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;background-color: rgb(255, 255, 255);\"><br  \/><\/span><\/strong><\/p>\n<p><span style=\"color: rgb(216, 79, 169);\"><strong>5.\u8bfa\u534eKymriah\u7684\u4e1a\u7ee9\uff0c2018H1 2800\u4e07\u7f8e\u5143 \uff0cQ2\u4e1a\u7ee9 1600\u4e07\u7f8e\u5143\u3002\u5355\u4e2a\u60a3\u8005\u8d39\u7528\u572847.5\u4e07\u7f8e\u5143\u3002<\/strong><\/span><\/p>\n<p><strong style=\"color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);\"><span style=\"font-family: sans-serif;font-size: 14px;background-color: rgb(255, 255, 255);color: rgb(51, 51, 51);\"><br  \/><\/span><\/strong><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533784615-1.jpg\" alt=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\" title=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\"  \/><\/p>\n<p><strong style=\"color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);\"><span style=\"font-family: sans-serif;font-size: 14px;background-color: rgb(255, 255, 255);color: rgb(51, 51, 51);\"><\/span><\/strong><br  \/><\/p>\n<p>6.\u76ee\u524d\u5728\u7f8e\u83b7\u6279\u4e24\u5927\u9002\u5e94\u75c7\u3002https:\/\/www.pharma.us.novartis.com\/sites\/www.pharma.us.novartis.com\/files\/kymriah.pdf\uff0c\u8bf4\u660e\u4e66\u94fe\u63a5\u5982\u4e0a\u3002<\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress3-1533784616.png\" alt=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\" title=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\"  \/><\/p>\n<p><strong style=\"color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);\"><span style=\"font-family: sans-serif;font-size: 14px;background-color: rgb(255, 255, 255);color: rgb(51, 51, 51);\"><\/span><\/strong><br  \/><\/p>\n<p><span style=\"color: rgb(216, 79, 169);\"><strong>\u4e8c.Gilead &amp;Kite\uff0cYecsrta\uff1a<\/strong><\/span><\/p>\n<p><span style=\"color: rgb(216, 79, 169);\"><strong>\uff08axicabtagene ciloleucel\uff09<\/strong><\/span><\/p>\n<p><span style=\"color: rgb(216, 79, 169);\"><strong><br  \/><\/strong><\/span><\/p>\n<p><span style=\"color: rgb(216, 79, 169);\"><strong>1.<\/strong><strong>2018\u5e74H1\u9500\u552e\u989d 1.08\u4ebf\u7f8e\u5143 \uff0cQ2 6800\u4e07\u7f8e\u5143\u3002\u5728\u7f8e\u56fd\u5e02\u573a\uff0cKite\u7684Yescarta\u5b9a\u4ef7\u4e3a37.3\u4e07\u7f8e\u5143\u3002<\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<p><strong>2.<\/strong><span style=\"background-color: rgb(255, 255, 255);color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;\">It was developed by California-based&nbsp;<\/span>Kite Pharma<span style=\"background-color: rgb(255, 255, 255);color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;\">.<\/span><\/p>\n<p style=\"margin-top: 0.5em;margin-bottom: 0.5em;line-height: inherit;color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);\">Axi-cel was awarded&nbsp;US FDA&nbsp;breakthrough therapy designation&nbsp;on October 18, 2017 for&nbsp;diffuse large B-cell lymphoma,&nbsp;transformed follicular lymphoma, and&nbsp;primary mediastinal B-cell lymphoma.&nbsp;It also received&nbsp;priority review&nbsp;and&nbsp;Orphan drug designation.<\/p>\n<p style=\"margin-top: 0.5em;margin-bottom: 0.5em;line-height: inherit;color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);\"><br  \/><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533784616.jpg\" alt=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\" title=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\"  \/><\/p>\n<p><br  \/><\/p>\n<p><strong><span style=\"color: rgb(216, 79, 169);\">\u4e09.\u56fd\u5185CAR-T\uff1a<\/span><\/strong><\/p>\n<p><br  \/><\/p>\n<p><strong>1.<strong style=\"color: rgb(51, 51, 51);\">\u590d\u661f\u51ef\u7279<\/strong><span style=\"background-color: rgb(255, 255, 255);color: rgb(51, 51, 51);\">\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u4ea7\u4e1a\u5316\u9879\u76ee:<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\u79df\u8d41\u4e0a\u6d77\u590d\u76db\u533b\u836f\u79d1\u6280\u53d1\u5c55\u6709\u9650\u516c\u53f8\u5382\u623f\uff0c\u5728\u4e2d\u8bd5\u697c1\u5c42\u65b0\u5efa\u751f\u4ea7\u5355\u5143\uff0c\u5e76\u5229\u7528\u5df2\u5efa\u6210\u7684\u4e2d\u8bd5\u697c\u73b0\u6709\u5b9e\u9a8c\u5355\u5143\u8fdb\u884c\u4ea7\u4e1a\u5316\u751f\u4ea7\uff0c<span style=\"color: rgb(216, 79, 169);\">\u76f8\u52a0\u603b\u89c4\u6a21\u4e3a\u5e74\u4ea73000\u4f8bCAR-T\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u4e2d\u6240\u9700\u7684\u7ec6\u80de<\/span>\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br  \/><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533784616.jpg\" alt=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\" title=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\"  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">CART \u540d\uff1a\u76ca\u57fa\u5229\u4ed1\u8d5b\uff08\u62df\u5b9a\uff09\uff0c\u63093\u7c7b\u751f\u7269\u65b0\u836f\u62a5\u3002KTE-C19\uff0caxicabtagene ciloleucel\u3002\u56fd\u5185\u57282018\u5e744\u6708\u9012\u4ea4\u4e86\u4e34\u5e8a\u7533\u8bf7\u3002<span style=\"color: rgb(43, 43, 43);\">FKC876\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"color: rgb(43, 43, 43);\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong><span style=\"color: rgb(43, 43, 43);\">2.#\u79d1\u6d4e\u5236\u836f#<span style=\"color: rgb(51, 51, 51);\">\u6709\u9650\u516c\u53f8<\/span>#\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1#<span style=\"color: rgb(51, 51, 51);\">\u5546\u4e1a\u5316\u751f\u4ea7\u57fa\u5730(\u2160\u671f)<\/span><\/span><\/strong><span style=\"color: rgb(43, 43, 43);\"><span style=\"color: rgb(51, 51, 51);\">\u3002<\/span>#\u505aCART\u5148\u5728\u56fd\u5185\u6709GMP\u8f66\u95f4#<span style=\"color: rgb(51, 51, 51);\">\u3002\u672c\u9879\u76ee\u5728\u4e0a\u6d77\u5e02\u91d1\u5c71\u5de5\u4e1a\u533a\u8c6a\u4e1a\u8def518\u53f7\u4e0a\u6d77\u5f20\u6c5f\u91d1\u5c71\u751f\u7269\u533b\u836f\u6807\u51c6\u4ea7\u4e1a\u56ed3\u53f7\u5382\u623f\u5f00\u8bbe\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u5546\u4e1a\u5316\u751f\u4ea7\u57fa\u5730\uff0c<\/span><\/span><span style=\"color: rgb(216, 79, 169);\">\u5e74\u4ea7\u5d4c\u5408\u6297\u539f\u53d7\u4f53\u4fee\u9970\u7684T\u7ec6\u80de\uff08CAR-T\uff093000\u4f8b<\/span><span style=\"color: rgb(51, 51, 51);\">\u3002 <\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"color: rgb(51, 51, 51);\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong><span style=\"color: rgb(51, 51, 51);\">3.\u836f\u660e\u5de8\u8bfa\uff1a<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong><span style=\"color: rgb(51, 51, 51);\"><br  \/><\/span><\/strong><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress6-1533784617.png\" alt=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\" title=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong><span style=\"color: rgb(51, 51, 51);\"><\/span><\/strong><br  \/><\/p>\n<p>\u836f\u660e\u5de8\u8bfa\u4eca\u5e743\u6708\u5b8c\u62109000\u4e07\u7f8e\u5143A\u8f6e\u878d\u8d44\uff0cTemasek\u6de1\u9a6c\u9521\u3001\u5143\u660e\u8d44\u672c\u3001\u7ea2\u6749\u8d44\u672c\u4e2d\u56fd\u8054\u5408\u9886\u6295\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"color: rgb(51, 51, 51);\"><br  \/><\/span><\/p>\n<p>6\u670827\u65e5\uff0c\u836f\u660e\u5de8\u8bfa\u53ca\u5176\u5173\u8054\u516c\u53f8\u4e0a\u6d77\u660e\u805a\u751f\u7269\u5ba3\u5e03\uff0c\u660e\u805a\u751f\u7269CAR-T\u4ea7\u54c1<strong><span style=\"color: rgb(216, 79, 169);\">JWCAR029<\/span><\/strong>\u7684IND\u7533\u8bf7\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u3002<br  \/><\/p>\n<p><br  \/><\/p>\n<p><strong>4.\u4f20\u5947\u751f\u7269\uff1a<\/strong><\/p>\n<section class=\"\"><br  \/><\/section>\n<section class=\"\">\u57282018\u5e743\u6708\uff0cCFDA\/CNDA\u6279\u51c6\u4e86\u91d1\u65af\u745e\u65d7\u4e0b\u4f20\u5947\u751f\u7269<span style=\"color: rgb(216, 79, 169);\">LCAR-B38M CAR-T\u7ec6\u80de\u81ea\u4f53\u56de\u8f93\u5236\u5242<\/span>\u4e34\u5e8a\uff0c\u7b2c\u4e00\u5bb6\u83b7\u6279\u6b63\u89c4\u4e34\u5e8a\u7684Biotech\u3002<br  \/><\/section>\n<p><br  \/><\/p>\n<p>&nbsp;\u53e6\u5916\uff0c2018\u5e745\u670830\u65e5\uff0c\u4f20\u5947\u751f\u7269\u5ba3\u5e03\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6388\u6743\u4f20\u5947\u751f\u7269\u7684\u5408\u4f5c\u4f19\u4f34\u2014\u2014Janssen Biotech, Inc. (\u201cJanssen\u201d)\u5c31\u5176\u9488\u5bf9\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u7684CAR-T\u7ec6\u80de\u7597\u6cd5LCAR-B38M (JNJ-68284528)\u5f00\u5c551b\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u8bc4\u4f30\u8be5\u4ea7\u54c1\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n<p><span style=\"max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 1px;font-size: 14px;color: rgb(127, 127, 127);box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong style=\"color: rgb(0, 0, 0);\">5.\u5df2\u7533\u62a5IND\u7684\u7ec6\u80de\u6cbb\u7597\uff1a<\/strong><span style=\"color: rgb(51, 51, 51);\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br  \/><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533784617.png\" alt=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\" title=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\"  \/><\/p>\n<p><br  \/><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533784617.png\" alt=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\" title=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\"  \/><\/p>\n<p><br  \/><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533784617.png\" alt=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\" title=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;color: rgb(51, 51, 51);\">\n<section  class=\"\"  style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;font-family: Helvetica, Arial, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress1-1533784617.jpg\" alt=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\" title=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-family: Helvetica, Arial, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;font-family: Helvetica, Arial, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section class=\"\"><span style=\"color: rgb(216, 79, 169);\">\u6211\u56fd\u836f\u5ba1\u4e2d\u5fc3(CDE)\u4e8e5\u670823\u65e5\u7ec4\u7ec7CAR-T\u6cbb\u7597\u590d\u53d1\u96be\u6cbb\u6027\u6025\u6027B\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08R\/R B-ALL\uff09\u4e13\u5bb6\u7814\u8ba8\u4f1a<\/span>\uff0c\u9080\u8bf7\u6211\u56fd\u8fd1\u4e8c\u5341\u540d\u6210\u4eba\u548c\u513f\u7ae5\u8840\u6db2\u80bf\u7624\u65b9\u9762\u7684\u4e34\u5e8a\u4e13\u5bb6\uff0c\u5bf9\u56fd\u5185\u5df2\u7533\u62a5\u54c1\u79cd\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848\u4e2d\u5b58\u5728\u7684\u82e5\u5e72\u5171\u6027\u95ee\u9898\u8fdb\u884c\u4e86\u8ba8\u8bba\u3002<\/section>\n<p><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p>\u836f\u5ba1\u4e2d\u5fc3\u751f\u7269\u5236\u54c1\u4e34\u5e8a\u90e8\u7ec6\u80de\u6cbb\u7597\u548c\u57fa\u56e0\u6cbb\u7597\u9002\u5e94\u75c7\u5c0f\u7ec4\u4ecb\u7ecd\u4e86\u56fd\u5185\u5916CAR-T\u6cbb\u7597R\/R B-ALL\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848\u4e2d\u53d7\u8bd5\u4eba\u7fa4\u3001\u5165\u7ec4\u6807\u51c6\u3001\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u548c\u98ce\u9669\u63a7\u5236\u7b49\u65b9\u9762\u7684\u57fa\u672c\u60c5\u51b5\u548c\u5b58\u5728\u7684\u4e00\u4e9b\u5171\u6027\u95ee\u9898\u3002\u7ecf\u8ba8\u8bba\uff0c\u4e0e\u4f1a\u4e13\u5bb6\u9488\u5bf9\u4e0d\u540c\u5e74\u9f84\u6bb5\u60a3\u8005\u7684\u8bd5\u9a8c\u5206\u7ec4\u3001\u590d\u53d1\u96be\u6cbb\u60a3\u8005\u7684\u5165\u7ec4\u6807\u51c6\u3001\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u3001\u98ce\u9669\u63a7\u5236\u539f\u5219\u7b49\u8fbe\u6210\u4e00\u81f4\u610f\u89c1\u3002<span style=\"color: rgb(216, 79, 169);\">\u540e\u7eed\uff0c\u836f\u5ba1\u4e2d\u5fc3\u5c06\u53c2\u8003\u4ee5\u4e0a\u610f\u89c1\u7ec4\u7ec7\u8d77\u8349\u76f8\u5173\u7684\u6280\u672f\u6307\u5357<\/span>\u3002<\/p>\n<p style=\"margin-top: 0.5em;margin-bottom: 0.5em;line-height: inherit;color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);\"><sup class=\"reference\" style=\"line-height: 1;unicode-bidi: isolate;white-space: nowrap;font-size: 11.2px;\"><br  \/><\/sup><\/p>\n<p><span style=\"font-size: 18px;\"><strong><span style=\"color: rgb(216, 79, 169);\">\u66f4\u591a\u4fe1\u606f\u53c2\u8003\uff1a<\/span><\/strong><\/span><br  \/><\/p>\n<p><br  \/><\/p>\n<p>https:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm574058.htm\uff1b<\/p>\n<p>https:\/\/www.us.kymriah.com\/acute-lymphoblastic-leukemia-children\/about-treatment\/understanding-treatment\/\uff1b<\/p>\n<p>https:\/\/www.pharma.us.novartis.com\/sites\/www.pharma.us.novartis.com\/files\/kymriah.pdf<strong style=\"white-space: normal;color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;background-color: rgb(255, 255, 255);\"><span style=\"color: rgb(51, 51, 51);\">\uff1b<\/span><\/strong><\/p>\n<p>https:\/\/www.novartis.com\/sites\/www.novartis.com\/files\/q2-2018-ir-presentation.pdf<strong style=\"white-space: normal;color: rgb(34, 34, 34);font-family: sans-serif;font-size: 14px;background-color: rgb(255, 255, 255);\"><span style=\"color: rgb(51, 51, 51);\">\uff1b<\/span><\/strong><\/p>\n<p>https:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm581216.htm\uff1b<\/p>\n<p>https:\/\/www.fda.gov\/BiologicsBloodVaccines\/CellularGeneTherapyProducts\/ApprovedProducts\/ucm581222.htm;<\/p>\n<p>https:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/CellularGeneTherapyProducts\/ApprovedProducts\/UCM581226.pdf\uff1b<\/p>\n<h1>CAR T Cells: Engineering Patients\u2019 Immune Cells to Treat Their Cancers\uff0chttps:\/\/www.cancer.gov\/about-cancer\/treatment\/research\/car-t-cells\uff1b<\/h1>\n<p>https:\/\/www.cancer.gov\/news-events\/cancer-currents-blog\/2017\/car-t-cell-multiple-myeloma\uff1b<\/p>\n<p>https:\/\/mp.weixin.qq.com\/s\/MD3iYX2O4ZDmZjKZA6dL7g\uff0c\u7b49\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(171, 25, 66);box-sizing: border-box !important;word-wrap: break-word !important;\">\u836f\u878d\u5708\u4e3a\u836f\u7269\u7b80\u8baf\u5408\u4f5c\u5e73\u53f0.<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img  class=\"\"    style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress6-1533784618.jpg\" alt=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\" title=\"CAR-T\u7684\u6c5f\u6e56 \u3010\u836f\u7269\u7b80\u8baf20180807\u3011\"  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u7269\u7b80\u8baf                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4e00.\u5168\u7403\u9996\u6b3e\u4e0a\u5e02CAR-T: 1.Tisagenlecleucel, marketed as&nbsp;Kym [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":22751,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/22750"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=22750"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/22750\/revisions"}],"predecessor-version":[{"id":22771,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/22750\/revisions\/22771"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/22751"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=22750"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=22750"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=22750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}