{"id":22853,"date":"2018-08-02T01:00:00","date_gmt":"2018-08-09T03:17:27","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e5%9b%bd%e4%ba%a7pd-1%ef%bc%9a%e5%bc%80%e5%b1%95%e9%a6%96%e4%b8%aa%e5%be%ae%e5%8d%ab%e6%98%9f%e9%ab%98%e5%ba%a6%e4%b8%8d%e7%a8%b3%e5%ae%9a%e6%88%96%e5%9f%ba%e5%9b%a0%e9%94%99%e9%85%8d%e4%bf%ae\/"},"modified":"2018-08-09T11:17:29","modified_gmt":"2018-08-09T03:17:29","slug":"%e5%9b%bd%e4%ba%a7pd-1%ef%bc%9a%e5%bc%80%e5%b1%95%e9%a6%96%e4%b8%aa%e5%be%ae%e5%8d%ab%e6%98%9f%e9%ab%98%e5%ba%a6%e4%b8%8d%e7%a8%b3%e5%ae%9a%e6%88%96%e5%9f%ba%e5%9b%a0%e9%94%99%e9%85%8d%e4%bf%ae","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/22853\/","title":{"rendered":"\u56fd\u4ea7PD-1\uff1a\u5f00\u5c55\u9996\u4e2a\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u6216\u57fa\u56e0\u9519\u914d\u4fee\u590d\u7f3a\u9677 II\u671f\u4e34\u5e8a"},"content":{"rendered":"
\n

\u4e00.\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u6216\u57fa\u56e0\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff1a<\/strong><\/span><\/p>\n

MSI\uff0cmicrosatellite instability\uff0c\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\uff1b<\/p>\n

dMMR\uff0cmismatch repair deficiency\uff0cDNA\u9519\u914d\u4fee\u590d\u7f3a\u9677\u3002<\/p>\n

<\/p>\n

\u9ad8\u5ea6\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a(MSI-H)\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677(dMMR)\u662f\u9057\u4f20\u53d8\u5f02\u73b0\u8c61\u3002\u5fae\u536b\u661f\u5b58\u5728\u4e8e\u57fa\u56e0\u7ec4\u4e2d\u7684\u7b80\u5355\u4e32\u8054\u91cd\u590d\u5e8f\u5217\uff0c\u5f53\u9519\u914d\u4fee\u590d\u57fa\u56e0\u529f\u80fd\u7f3a\u9677(dMMR)\u65f6\uff0c\u5f71\u54cdDNA\u7684\u4fee\u590d\u673a\u5236\uff0c\u8fdb\u800c\u5bfc\u81f4DNA\u94fe\u9519\u914d\u7684\u79ef\u7d2f\uff0c\u4ece\u800c\u4f1a\u5f15\u8d77\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a(MSI)\u3002<\/p>\n

<\/p>\n

\u4e8c.2017\u5e74\uff0cKeytruda\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u5e26\u6709\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u9ad8(MSI-H)\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677(dMMR)\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u3002<\/span><\/strong><\/p>\n

<\/p>\n

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<\/p>\n

\"\u56fd\u4ea7PD-1\uff1a\u5f00\u5c55\u9996\u4e2a\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u6216\u57fa\u56e0\u9519\u914d\u4fee\u590d\u7f3a\u9677<\/p>\n

\"\u56fd\u4ea7PD-1\uff1a\u5f00\u5c55\u9996\u4e2a\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u6216\u57fa\u56e0\u9519\u914d\u4fee\u590d\u7f3a\u9677<\/p>\n

<\/p>\n

\u4e09.\u6cf0\u5dde\u7ff0\u4e2d\u65d7\u4e0b\u8d44\u4ea7PD-1\uff0c\u5c55\u5f00\u76f8\u5173\u4e34\u5e8a\u3002<\/span><\/strong><\/p>\n

<\/p>\n\n\n\n\n\n\n\n
\n

\u767b\u8bb0\u53f7\uff1a<\/span><\/strong><\/p>\n<\/td>\n

\n

CTR20181269<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/strong>\u9002\u5e94\u75c7\uff1a<\/span><\/strong><\/p>\n<\/td>\n

\n

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\n

 <\/strong>\u8bd5\u9a8c\u901a\u4fd7\u9898\u76ee\uff1a<\/span><\/strong><\/p>\n<\/td>\n

\n

HX008 \u6ce8\u5c04\u6db2\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u7684\u591a\u4e2d\u5fc3\u3001\u5f00<\/span>  \u653e\u3001<\/span>II \u671f\u4e34\u5e8a\u7814\u7a76<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

 <\/strong>\u8bd5\u9a8c\u4e13\u4e1a\u9898\u76ee\uff1a<\/span><\/strong><\/p>\n<\/td>\n

\n

\u91cd\u7ec4\u4eba\u6e90\u5316\u6297<\/span> PD-1 \u5355\u514b\u9686\u6297\u4f53<\/span> HX008 \u6ce8\u5c04\u6db2\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u7684\u591a\u4e2d\u5fc3\u3001\u5f00<\/span> \u653e\u3001<\/span>II \u671f\u4e34\u5e8a\u7814\u7a76<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7533\u529e\u8005\u540d\u79f0\uff1a<\/span><\/strong><\/p>\n<\/td>\n

\n

\u6cf0\u5dde\u7ff0\u4e2d<\/span>\/\u676d\u5dde\u7ff0\u601d<\/span>\/\u5eb7\u65b9\u751f\u7269<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

 <\/p>\n\n\n\n\n\n\n
\n

\u7533\u529e\u8005\u8054\u7cfb\u4eba\u59d3\u540d\uff1a<\/span><\/strong><\/p>\n<\/td>\n

\n

\u6c64\u654f<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

 <\/strong>\u8054\u7cfb\u4eba\u7535\u8bdd\uff1a<\/span><\/strong><\/p>\n<\/td>\n

\n

15971460298<\/p>\n<\/td>\n

\n

 \u8054\u7cfb\u4eba<\/span>Email\uff1a<\/span><\/p>\n<\/td>\n

\n

jing.yang@hanxbio.com<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/strong>\u8054\u7cfb\u4eba\u90ae\u653f\u5730\u5740\uff1a<\/span><\/strong><\/p>\n<\/td>\n

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\n

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\n

430074<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/strong>\u8bd5\u9a8c\u9879\u76ee\u7ecf\u8d39\u6765\u6e90\uff1a<\/span><\/strong><\/p>\n<\/td>\n

\n

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<\/p>\n

\u4e3b\u8981\u76ee\u7684\uff1a\u63a2\u7d22 HX008 \u6ce8\u5c04\u6db2\u8054\u5408\u4f0a\u7acb\u66ff\u5eb7\u6cbb\u7597\u7ecf\u4e00\u7ebf\u5316\u7597\u5931\u8d25\u540e\u7684\u665a\u671f\u80c3\u817a\u764c\u7684\u6709\u6548\u6027\uff08\u5ba2\u89c2\u7f13\u89e3\u7387ORR\uff09\uff1b\u8bc4\u4f30\u91cd\u7ec4\u4eba\u6e90\u5316\u6297 PD-1 \u5355\u514b\u9686\u6297\u4f53 HX008 \u6ce8\u5c04\u6db2\u5355\u836f\u6cbb\u7597\u9ad8\u5ea6\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u578b(MSI-H)\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u578b(dMMR)\u665a\u671f\u5b9e\u4f53\u7624\u7684\u6709\u6548\u6027\uff08\u5ba2\u89c2\u7f13\u89e3\u7387ORR\uff09\u3002<\/p>\n

<\/p>\n

\u62db\u52df\u4eba\u6570\uff1a\u56fd\u5185\u8bd5\u9a8c:123~138\u4eba\u3002<\/p>\n

<\/p>\n\n\n\n\n
\n

\u540d\u79f0<\/span><\/strong><\/p>\n<\/td>\n

\n

\u7528\u6cd5<\/span><\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

HX008 <\/strong>\u6ce8\u5c04\u5242<\/span><\/strong><\/p>\n<\/td>\n

\n

\u6ce8\u5c04\u6db2\uff1b\u89c4\u683c<\/span>10mL:100mg\/\u74f6\uff1b\u961f\u5217<\/span>1\uff1a\u9759\u8109\u6ef4\u6ce8\uff1b\u5242\u91cf\uff1a<\/span>200mg\uff0c\u8f93\u6db2\u65f6\u95f4\u4e3a<\/span>60min\uff08\u00b1<\/span>15 min\uff09\uff0c\u6bcf<\/span>3\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u961f\u5217<\/span>2:\u9759\u8109\u6ef4\u6ce8\uff1b\u5242\u91cf\uff1a<\/span>200mg\uff1b\u8f93\u6db2\u65f6\u95f4\u4e3a<\/span>60 min\uff08\u00b1<\/span>15 min\uff09\uff0c\u6bcf<\/span>3\u5468\u7ed9\u836f\u4e00\u6b21<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/p>\n

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<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u836f\u7269\u7b80\u8baf <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e00.\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u6216\u57fa\u56e0\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff1a MSI\uff0cmicrosatellite instability\uff0c\u5fae\u536b\u661f […]<\/p>\n","protected":false},"author":1,"featured_media":22854,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/22853"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=22853"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/22853\/revisions"}],"predecessor-version":[{"id":22862,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/22853\/revisions\/22862"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/22854"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=22853"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=22853"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=22853"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}