{"id":22894,"date":"2018-08-06T01:00:00","date_gmt":"2018-08-09T03:17:46","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e7%bb%86%e8%83%9e%e7%96%97%e6%b3%95%e3%80%81%e5%9f%ba%e5%9b%a0%e7%96%97%e6%b3%95%ef%bc%9a%e7%a5%9e%e7%bb%8f%e7%b2%be%e7%a5%9e%e7%96%be%e7%97%85%e9%a2%86%e5%9f%9f%e6%b2%bb%e7%96%97%e7%aa%81%e7%a0%b4\/"},"modified":"2018-08-09T11:17:49","modified_gmt":"2018-08-09T03:17:49","slug":"%e7%bb%86%e8%83%9e%e7%96%97%e6%b3%95%e3%80%81%e5%9f%ba%e5%9b%a0%e7%96%97%e6%b3%95%ef%bc%9a%e7%a5%9e%e7%bb%8f%e7%b2%be%e7%a5%9e%e7%96%be%e7%97%85%e9%a2%86%e5%9f%9f%e6%b2%bb%e7%96%97%e7%aa%81%e7%a0%b4","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/22894\/","title":{"rendered":"\u7ec6\u80de\u7597\u6cd5\u3001\u57fa\u56e0\u7597\u6cd5\uff1a\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u9886\u57df\u6cbb\u7597\u7a81\u7834\u6027\u8fdb\u5c55"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"_editor\">\n<section style=\"width: 100%;vertical-align: top;border-width: 3px;border-radius: 8px;border-style: solid;border-color: #b1b1b1;background-color: #f5f5f5;padding: 20px 17px;box-sizing: border-box;\" >\n<section>\n<section style=\"box-sizing: border-box;\">\n<section style=\"line-height: 2;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;letter-spacing: 2px;\"><span style=\"font-family: sans-serif;font-size: 14px;text-indent: 28px;\">\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u6db5\u76d6600\u591a\u4e2a\u9002\u5e94\u75c7\uff0c\u8bf8\u591a\u75be\u75c5\u7684\u53d1\u75c5\u673a\u5236\u590d\u6742\u4e14\u5c1a\u672a\u63a2\u660e\uff0c\u836f\u7269\u7814\u53d1\u8fc7\u7a0b\u56f0\u96be\u91cd\u91cd\uff0c\u5982\u5728\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u9886\u57df\uff0c\u7814\u53d1\u5931\u8d25\u7387\u9ad8\u8fbe99%\u3002\u8fd1\u51e0\u5e74\u6765\uff0c\u968f\u7740\u751f\u7269\u6280\u672f\u3001\u57fa\u56e0\u7ec4\u5b66\u7b49\u6280\u672f\u7684\u53d1\u5c55\uff0c\u591a\u4e2a\u65b0\u673a\u5236\u65b0\u9776\u70b9\u7684\u751f\u7269\u836f\u88ab\u6279\u4e0a\u5e02\u6216\u5904\u4e8e\u4e34\u5e8a\u540e\u671f\u7814\u53d1\uff0c\u8be5\u7c7b\u75be\u75c5\u7684\u6cbb\u7597\u53d6\u5f97\u4e86\u7a81\u7834\u6027\u8fdb\u5c55\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section>\n<section style=\"text-align: center;margin: -25px 0% 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;width: 13%;box-sizing: border-box;\" ><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" x=\"0px\" y=\"0px\" viewbox=\"0 0 177.5 177.5\" style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\" width=\"100%\"><g style=\"box-sizing: border-box;\"><path d=\"M7.5,88.8c0,44.9,36.4,81.3,81.3,81.3S170,133.6,170,88.8S133.6,7.5,88.8,7.5S7.5,43.9,7.5,88.8z\" fill=\"rgb(255,210,0)\" style=\"box-sizing: border-box;\"><\/path><path style=\"box-sizing: border-box;\" d=\"M88.8,177.5C39.8,177.5,0,137.7,0,88.8C0,39.8,39.8,0,88.8,0c48.9,0,88.8,39.8,88.8,88.8    C177.5,137.7,137.7,177.5,88.8,177.5z M88.8,15C48.1,15,15,48.1,15,88.8s33.1,73.8,73.8,73.8s73.8-33.1,73.8-73.8S129.4,15,88.8,15    z\" fill=\"rgb(177,177,177)\"><\/path><\/g><g style=\"box-sizing: border-box;\"><path style=\"box-sizing: border-box;\" d=\"M88.4,117.5c-1.6,0-3.1-0.6-4.4-1.9l-46.6-45c-2.5-2.5-2.5-6.3,0-8.7s6.3-2.5,8.8,0l42.2,40.9    l42.8-40.9c2.5-2.5,6.6-2.2,8.8,0.3c2.5,2.5,2.2,6.6-0.3,8.8l-46.9,45C91.6,116.9,90,117.5,88.4,117.5L88.4,117.5z\" fill=\"rgb(255, 255, 255)\"><\/path><\/g><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">2013\u5e74\u81f3\u4eca\u5e74\u4e0a\u534a\u5e74\uff0c\u9488\u5bf9\u795e\u7ecf\u7cbe\u795e\u75be\u75c5FDA\u5171\u6279\u51c6\u4e866\u4e2a\u7a81\u7834\u6027\u751f\u7269\u836f\uff08\u4e0d\u5305\u542b\u8bca\u65ad\u8bd5\u5242\uff09\uff0c\u5206\u522b\u4e3a2016\u5e74\u6279\u51c6\u7684\u591a\u53d1\u6027\u786c\u5316\u75c7\u6cbb\u7597\u836fZinbryta(daclizumab\uff0c\u5355\u6297)\u3001\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u6cbb\u7597\u836fExondys 51\uff08eteplirsen\uff0c\u53cd\u4e49RNA\uff09\u3001\u810a\u9ad3\u6027\u808c\u840e\u7f29\u6cbb\u7597\u836fSpinraza\uff08nusinersen\uff0c\u53cd\u4e49RNA\uff09\uff0c2017\u5e74\u6279\u51c6\u7684\u591a\u53d1\u6027\u786c\u5316\u75c7\u6cbb\u7597\u836fOcrevus\uff08ocrelizumab\uff0c\u5355\u6297\uff09\u548c\u795e\u7ecf\u5143\u8721\u6837\u8102\u8910\u8d28\u6c89\u79ef\u75c7\u6cbb\u7597\u836fBrineura\uff08cerliponase alfa\uff0c\u86cb\u767d\uff09\u4ee5\u53ca2018\u5e745\u6708\u4efd\u88ab\u6279\u7684\u504f\u5934\u75db\u9884\u9632\u836f\u7269Aimovig\uff08erenumab\uff0c\u5355\u6297\uff09\uff08\u56fe1\uff09\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u4eca\u5e744\u6708\u4efd\uff0c\u65e5\u672c\u6279\u51c6\u4e86\u97e9\u56fd\u751f\u7269\u6280\u672f\u516c\u53f8NatureCell\u81ea\u4f53\u8102\u80aa\u6765\u6e90\u7684\u5e72\u7ec6\u80de\u836f\u7269AstroStem\u7528\u4e8e\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u6cbb\u7597\uff0c\u5728\u65e5\u672c\u798f\u5188\u4e09\u4e00\u8bca\u6240\uff08TrinityClinic Fukuoka\uff09\u8fdb\u884c\u5546\u4e1a\u5316\u4f7f\u7528\u3002\u8be5\u836f\u5728\u7f8e\u56fd\u5df2\u5728\u5f00\u5c55\u2160\/\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u5e76\u5df2\u6709\u60a3\u8005\u5165\u7ec4\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;\"><img loading=\"lazy\" class=\"\"     height=\"302\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u7ec6\u80de\u7597\u6cd5\u3001\u57fa\u56e0\u7597\u6cd5\uff1a\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u9886\u57df\u6cbb\u7597\u7a81\u7834\u6027\u8fdb\u5c55\" width=\"600\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress4-1533784666.jpeg\" alt=\"\u7ec6\u80de\u7597\u6cd5\u3001\u57fa\u56e0\u7597\u6cd5\uff1a\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u9886\u57df\u6cbb\u7597\u7a81\u7834\u6027\u8fdb\u5c55\"><\/p>\n<p style=\"text-align:center;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);\"><span style=\"text-indent: 2em;\">\u56fe1\uff1a2013\u5e74\u81f3\u4ecaFDA\u6279\u51c6\u7684\u5177\u6709\u91cd\u5927\u7a81\u7834\u7684\u751f\u7269\u6cbb\u7597\u836f<\/span><\/p>\n<p style=\"text-align: center;\"><\/p>\n<p style=\"text-align: center;\"><\/p>\n<section style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 2.0em;margin-right: -0.7em;overflow: hidden !important;box-sizing: border-box;transform: rotate(0deg);-webkit-transform: rotate(0deg);-moz-transform: rotate(0deg);-ms-transform: rotate(0deg);-o-transform: rotate(0deg);\"><img  style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\"   class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress0-1533784667.png\" alt=\"\u7ec6\u80de\u7597\u6cd5\u3001\u57fa\u56e0\u7597\u6cd5\uff1a\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u9886\u57df\u6cbb\u7597\u7a81\u7834\u6027\u8fdb\u5c55\" title=\"\u7ec6\u80de\u7597\u6cd5\u3001\u57fa\u56e0\u7597\u6cd5\uff1a\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u9886\u57df\u6cbb\u7597\u7a81\u7834\u6027\u8fdb\u5c55\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;padding: 2px;border-radius: 4px;margin-top: 0.8em;background-color: rgba(197, 227, 211, 0.498039);box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: dashed;border-color: #ffffff;padding-right: 15px;padding-left: 15px;border-radius: 4px;line-height: 1.6;color: #36395e;font-size: 18px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"text-shadow: #feec75 1.73205px -1px 0px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">&nbsp; <strong>\u7ec6\u80de\u7597\u6cd5<\/strong>&nbsp;<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<p><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\u636eClarivate Analytics Cortellis\u6570\u636e\u5e93\u663e\u793a\uff0c\u76ee\u524d\u795e\u7ecf\u7cbe\u795e\u9886\u57df\u6cbb\u7597\u751f\u7269\u836f\u5df2\u5728\u6ce8\u518c\u548c\u4e34\u5e8a\u5728\u7814\u9636\u6bb5\u7684\u6709400\u591a\u4e2a\uff0c\u5176\u4e2d\u7ec6\u80de\u6cbb\u7597\u836f\u7269\u670972\u4e2a\uff0c\u5360\u6240\u6709\u7ec6\u80de\u7597\u6cd5\u603b\u6570\uff08701\u4e2a\uff09\u768410%\u3002\u5904\u4e8e\u6ce8\u518c\u9636\u6bb5\u7684\u67092\u4e2a\uff0c\u4e34\u5e8a\u2162\u671f\u67098\u4e2a\uff0c\u4e34\u5e8a\u2161\u671f\u670933\u4e2a\uff0c\u4e34\u5e8a\u2160\u671f\u670923\u4e2a\uff0c\u4e34\u5e8a\u6ce8\u518c\u9636\u6bb5\u7684\u67096\u4e2a\u3002\u4e34\u5e8a\u2161\u671f\u81f3\u6ce8\u518c\u9636\u6bb5\u7684\u7ec6\u80de\u7597\u6cd5\u8be6\u60c5\u89c1\u88681\u3002\u9002\u5e94\u75c7\u6d89\u53ca\u810a\u9ad3\u635f\u4f24\u3001\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u3001\u810a\u9ad3\u6027\u808c\u840e\u7f29\u75c7\u3001\u4ea8\u5ef7\u987f\u821e\u8e48\u75c7\u3001\u5e15\u91d1\u68ee\u75c5\u3001\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u3001\u795e\u7ecf\u6bcd\u7ec6\u80de\u7624\u3001\u591a\u53d1\u6027\u786c\u5316\u75c7\u7b49\u591a\u79cd\u75be\u75c5\u3002<\/span><\/p>\n<p style=\"text-align:center;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;\">\u88681\uff1a\u4e34\u5e8a\u2161\u671f\u81f3\u6ce8\u518c\u9636\u6bb5\u7684\u5728\u7814\u7ec6\u80de\u7597\u6cd5&nbsp;<\/p>\n<p style=\"text-align: center;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;\"><img loading=\"lazy\" class=\"\"        height=\"3526\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u7ec6\u80de\u7597\u6cd5\u3001\u57fa\u56e0\u7597\u6cd5\uff1a\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u9886\u57df\u6cbb\u7597\u7a81\u7834\u6027\u8fdb\u5c55\" width=\"600\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533784667.jpeg\" alt=\"\u7ec6\u80de\u7597\u6cd5\u3001\u57fa\u56e0\u7597\u6cd5\uff1a\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u9886\u57df\u6cbb\u7597\u7a81\u7834\u6027\u8fdb\u5c55\"><\/p>\n<p><span style=\"font-family: sans-serif;background-color: rgb(255, 255, 255);font-size: 10px;\"><\/span><span style=\"font-family: sans-serif;font-size: 14px;background-color: rgb(255, 255, 255);\"><\/span><\/p>\n<p style=\"text-align:left;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;\"><span style=\"font-size: 10px;\">*\u5728\u7814\u9002\u5e94\u75c7\uff1a\u8be5\u836f\u7269\u5bf9\u67d0\u79cd\u9002\u5e94\u75c7\u6cbb\u7597\u7814\u7a76\u5904\u4e8e\u53d1\u73b0\u3001\u4e34\u5e8a\u3001\u6ce8\u518c\u6216\u4e0a\u5e02\u9636\u6bb5\uff1b<\/span><\/p>\n<p style=\"text-align:left;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;\"><span style=\"font-size: 10px;\">**\u6700\u9ad8\u7814\u53d1\u9636\u6bb5\uff1a\u8be5\u836f\u7269\u9488\u5bf9\u6240\u6709\u5728\u7814\u9002\u5e94\u75c7\u8fdb\u5c55\u6700\u5feb\u7684\u72b6\u6001\uff0c\u4e0d\u4e00\u5b9a\u662f\u9488\u5bf9\u795e\u7ecf\u7cbe\u795e\u9886\u57df\u7684\u9002\u5e94\u75c7\uff1b<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\"><strong><span style=\"color: rgb(0, 102, 0);font-weight: normal;\">STR-01<\/span><\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">STR-01\u662f\u65e5\u672c\u672d\u5e4c\u5927\u5b66\u548cNipro\u516c\u53f8\u8054\u5408\u5f00\u53d1\u7684\u81ea\u4f53\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\uff0c\u7528\u4e8e\u810a\u9ad3\u635f\u4f24\u548c\u4e2d\u98ce\u7684\u6f5c\u5728\u6cbb\u7597\u30022018\u5e746\u6708\uff0cNipro\u5411\u65e5\u672c\u539a\u751f\u52b3\u52a8\u7701\u63d0\u4ea4\u4e86STR-01\u9488\u5bf9\u810a\u9ad3\u635f\u4f24\u6cbb\u7597\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u8be5\u836f\u9488\u5bf9\u4e2d\u98ce\u7684\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u8fd8\u5728\u8fdb\u884c\u4e2d\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\"><strong><span style=\"color: rgb(0, 102, 0);font-size: 16px;font-weight: normal;\">YYB-103<\/span><\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">YYB-103\u662f\u97e9\u56fdYooYoung\u5236\u836f\u516c\u53f8\u5728\u7814\u7684\u4ebaIL13R-\u03b1-2\u7279\u5f02\u6027\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09T\u7ec6\u80de\uff0c\u7528\u4e8eALS\u548c\u795e\u7ecf\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u6f5c\u5728\u6cbb\u7597\uff0c\u76ee\u524d\u5df2\u9488\u5bf9ALS\u63d0\u4ea4\u4e86\u4e0a\u5e02\u7533\u8bf7\u3002\u4eca\u5e745\u6708\u4efd\uff0c\u8be5\u516c\u53f8\u5728\u7b2c21\u5c4a\u7f8e\u56fd\u57fa\u56e0\u4e0e\u7ec6\u80de\u6cbb\u7597\u5b66\u4f1a\u5e74\u4f1a\uff08ASGCT)\u4e0a\u516c\u5e03\u4e86YYB-103\u7528\u4e8e\u795e\u7ecf\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u4e34\u5e8a\u524d\u6570\u636e\u3002YYB-103\u80fd\u660e\u663e\u5ef6\u957f\u795e\u7ecf\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u6a21\u578b\u5c0f\u9f20\u7684\u4e2d\u4f4d\u751f\u5b58\u671f\u548c\u63d0\u9ad8130\u5929\u957f\u671f\u5b58\u6d3b\u7387\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\"><strong><span style=\"color: rgb(0, 102, 0);font-size: 16px;font-weight: normal;\">NurOwn<\/span><\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">NurOwn\u662fBrainStorm Cell Therapeutics\u516c\u53f8\u5f00\u53d1\u7684\u81ea\u4f53\u9aa8\u9ad3\u6765\u6e90\u7684\u3001\u5206\u6ccc\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08GDNF\u548cBDNF\uff09\u7684\u6210\u4eba\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff0c\u7528\u4e8e\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\u3001\u81ea\u95ed\u75c7\u3001\u5e15\u91d1\u68ee\u75c5\u3001\u810a\u9ad3\u635f\u4f24\u3001\u591a\u53d1\u6027\u786c\u5316\u75c7\u3001\u5750\u9aa8\u795e\u7ecf\u75db\u548c\u4ea8\u5ef7\u987f\u821e\u8e48\u75c7\u7684\u6f5c\u5728\u6cbb\u7597\u30022017\u5e748\u6708\uff0c\u8be5\u836f\u5728ALS\u60a3\u8005\u4e2d\u5f00\u59cb\u4e86\u2162\u671f\u8bd5\u9a8c\uff08NCT03280056\uff09\uff0c\u9876\u7ebf\u6570\u636e\u9884\u8ba1\u57282019\u5e74\u516c\u5e03\u30022016\u5e74\uff0cBrainStorm\u516c\u53f8\u5ba3\u5e03\u4e86NurOwn\u5728\u7f8e\u56fd\u7684\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3002\u8be5\u8bd5\u9a8c\u4e3a\u5728\u7f8e\u56fd3\u4e2a\u533b\u9662\u8fdb\u884c\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\uff0c48\u4f8bALS\u60a3\u8005\uff0c\u5176\u4e2d36\u4f8b\u63a5\u53d7MSC-NTF\uff0c12\u4f8b\u4f5c\u4e3a\u5bf9\u7167\u3002\u7ec6\u80de\u7ecf\u808c\u8089\u548c\u690e\u7ba1\u5185\u6ce8\u5c04\u4e00\u6b21\uff0c\u968f\u8bbf6\u4e2a\u6708\u3002\u53ef\u89c1\u5e72\u7ec6\u80de\u6cbb\u7597\u660e\u663e\u5ef6\u7f13\u4e86ALS\u75be\u75c5\u7684\u8fdb\u7a0b\uff0c\u60a3\u8005\u75c7\u72b6\u5f97\u5230\u7f13\u89e3\uff0c\u80fd\u4ea7\u751f\u6709\u6548\u5e94\u7b54\uff0c\u4e14\u6cbb\u7597\u5b89\u5168\u3001\u65e0\u660e\u663e\u526f\u53cd\u5e94\u3002\u8be5\u836f\u88abFDA\u6388\u4e88\u5feb\u901f\u901a\u9053\u548c\u5b64\u513f\u836f\u8ba4\u5b9a\u3002\u7528\u4e8eALS\u6cbb\u7597\u7684\u5e72\u7ec6\u80de\u7597\u6cd5\u8fd8\u6709Neuralstem\u516c\u53f8\u7684NSI-566\uff0c\u76ee\u524d\u5df2\u5728\u7f8e\u56fd\u5b8c\u6210\u4e86\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u53d6\u5f97\u4e86\u79ef\u6781\u7684\u4e34\u5e8a\u7ed3\u679c\u3002\u6b64\u5916\uff0cNSI-566\u9488\u5bf9\u4e2d\u98ce\u7684\u4e34\u5e8a\u2161\u671f\u7814\u7a76\u5728\u4e2d\u56fd\u6b63\u5728\u5f00\u5c55\u4e2d\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"color: rgb(0, 102, 0);font-size: 16px;\">Bone marrow-derived allogeneic ischemia tolerant mesenchymal stem cell therapy\uff08itMSC\uff09\u548cNeurostem-AD<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\u5728\u4e34\u5e8a\u7814\u53d1\u7ba1\u7ebf\u4e0a\uff0c\u67093\u4e2a\u5e72\u7ec6\u80de\u7597\u6cd5\u7528\u4e8e\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u7684\u6f5c\u5728\u6cbb\u7597\uff0c\u5206\u522b\u4e3a\u5728\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u7684Stemedica Cell Technologies\u516c\u53f8\u7684\u9aa8\u9ad3\u6765\u6e90\u7684\u5f02\u57fa\u56e0\u4eba\u7f3a\u8840\u8010\u53d7\u6027\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08itMSC\uff09\u7597\u6cd5\u3001Medipost\u516c\u53f8\u7684\u8110\u5e26\u8840\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5Neurostem-AD\uff0c\u2160\u671f\u4e34\u5e8a\u7814\u7a76\u7684Longeveron\u516c\u53f8\u7684\u5f02\u57fa\u56e0\u4eba\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\uff0c\u53e6\u6709\u591a\u4e2a\u5904\u4e8e\u4e34\u5e8a\u524d\u7814\u7a76\u9636\u6bb5\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">Stemedica Cell Technologies\u6b63\u5728\u5bf9\u9aa8\u9ad3\u6765\u6e90\u7684\u5f02\u57fa\u56e0\u4eba\u7f3a\u8840\u8010\u53d7\u6027\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08itMSC\uff09\u7597\u6cd5\u7528\u4e8e\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u3001\u75f4\u5446\u548c\u521b\u4f24\u6027\u8111\u635f\u4f24\u7684\u6f5c\u5728\u5e94\u7528\u8fdb\u884c\u7814\u7a76\u30022015\u5e746\u6708\uff0cFDA\u6279\u51c6\u4e86\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5355\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u4ea4\u53c9\u3001\u5206\u671f\u7684\u2161a\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09\u7533\u8bf7\uff0c\u4ee5\u8bc4\u4f30\u5355\u6b21\u2163\u5242\u91cf\u7684\u5f02\u57fa\u56e0\u4eba\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u8f7b\u4e2d\u5ea6\u75f4\u5446\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u521d\u6b65\u7597\u6548\u30022016\u5e746\u6708\uff0c\u8bd5\u9a8c\u6b63\u5f0f\u5c55\u5f00\uff0c\u9884\u8ba1\u62db\u52dfAD\u60a3\u800540\u4eba\uff0c\u4e3b\u8981\u8bd5\u9a8c\u7ed3\u679c\u5c06\u57282019\u5e74\u5e95\u516c\u5e03\uff08NCT02833792\uff0cSTEM105-M-AD\uff09\u30022016\u5e745\u6708\uff0cFDA\u53c8\u6279\u51c6\u4e86\u8be5\u836f\u7684\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u8bc4\u4f30\u5728\u4e2d\u5ea6\u8111\u5916\u4f24\u60a3\u8005\u4e2d\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u521d\u6b65\u6709\u6548\u6027\u4e34\u5e8a\u2161a\u671f\u7814\u7a76\uff08\u9884\u671fn=24\uff09\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">Neurostem-AD\u662fMedipost\u516c\u53f8\u5f00\u53d1\u7684\u8110\u5e26\u8840\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\uff0c\u5177\u6709\u65c1\u5206\u6ccc\u6548\u5e94\u5e76\u6fc0\u6d3b\u795e\u7ecf\u5143\u652f\u6301\u7684\u8111\u7ec6\u80de\uff0c\u7528\u4e8e\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u548c\u5176\u4ed6\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u6f5c\u5728\u6cbb\u7597\u30022011\u5e74\uff0c\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u7684\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT01297218\uff09\u5728\u97e9\u56fdAD\u60a3\u8005\uff08n=9\uff09\u4e2d\u5c55\u5f00,9\u540d\u60a3\u8005\u9664\u4e86\u80cc\u666f\u6cbb\u7597\u5916\uff0c\u8fd8\u88ab\u7ed9\u4e883\u00d7\u62166\u00d7106\u4e2a\u7ec6\u80de\u7684\u5242\u91cf\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4ece\u57fa\u7ebf\u523012\u5468\uff0c\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u8bc4\u4f30\u91cf\u8868\u8ba4\u77e5\u603b\u5f97\u5206\u7684\u5e73\u5747\u53d8\u5316\u503c\u4e3a4.1\uff0c\u671f\u95f4\u65e0\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u30022012\u5e74\uff0c\u4e00\u9879\u8bc4\u4f30Neurostem-AD\u5728AD\u60a3\u8005\u4e2d\u957f\u671f\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u968f\u8bbf\u7814\u7a76\u2160\u671f\u4e34\u5e8a\uff08NCT01696591\uff09\u5728\u97e9\u56fd\u5c55\u5f00\uff08n=14\uff09\uff0c2014\u5e74\u4e0a\u534a\u5e74\u8be5\u8bd5\u9a8c\u5b8c\u6210\u30022014\u5e74\uff0c\u4e00\u9879\u968f\u673a\u3001\u4ecb\u5165\u3001\u5e73\u884c\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u53cc\u76f2\u3001\u5355\u4e2d\u5fc3\u7684\u2160\/\u2161a\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT02054208\uff09\u5728\u97e9\u56fdAD\u60a3\u8005\u4e2d\u5c55\u5f00\uff08\u9884\u8ba1n=40\uff09\uff0c\u7528\u4e8e\u8bc4\u4f30\u8be5\u836f\u8111\u5ba4\u5185\u6ce8\u5c04\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u76ee\u524d\u8be5\u7814\u7a76\u8fd8\u5728\u62db\u52df\u60a3\u8005\u4e2d\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\"><strong><span style=\"font-weight: normal;font-size: 16px;color: rgb(0, 102, 0);\">4SCAR-GD2<\/span><\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">4SCAR-GD2\u662f\u6df1\u5733\u5e02\u514d\u75ab\u57fa\u56e0\u6cbb\u7597\u7814\u7a76\u9662\u4e0e\u5357\u65b9\u533b\u79d1\u5927\u5b66\u73e0\u6c5f\u533b\u9662\u5408\u4f5c\u5f00\u53d1\u7684\u9776\u5411GD2\u6297\u539f\u7684\u7b2c\u56db\u4ee3CART\u6cbb\u7597\uff0c\u7528\u4e8e\u795e\u7ecf\u6bcd\u80f6\u8d28\u7624\u7684\u6f5c\u5728\u6cbb\u7597\u3002\u57282017\u5e74\u7b2c59\u5c4a\u7f8e\u56fd\u8840\u6db2\u75c5\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u4e0a\uff0c\u7814\u7a76\u8005\u516c\u5e03\u4e86\u4e3a\u671f3\u5e74\u7684\u591a\u4e2d\u5fc3\u2161\u671f\u7814\u7a76\uff08NCT02992210\u548cNCT02765243\uff09\u7684\u4e2d\u671f\u6570\u636e\uff0c\u8fd9\u4e24\u9879\u8bd5\u9a8c\u5747\u53d1\u8d77\u4e8e2016\u5e74\uff0c\u7528\u4e8e\u8bc4\u4f304SCAR-GD2\u5728\u9ad8\u5371\u2163\u7ea7\u795e\u7ecf\u6bcd\u80f6\u8d28\u7624\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u4ece\u4e94\u6240\u533b\u9662\u62db\u52df\u7684\u60a3\u8005\uff08n\uff1d34\uff09\u5728\u7b2c0\u5929\u63a5\u53d71.1\u00d7106\/kg\u76844SCAR-GD2 T\u7ec6\u80de\u7684\u8f93\u6ce8\u3002\u5728\u57fa\u4e8eNCI\u5171\u540c\u6bd2\u6027\u6807\u51c6\u8fdb\u884c\u7684\u6bd2\u6027\u5206\u6790\u4e2d\uff0c24%\u7684\u60a3\u8005\u6ca1\u6709\u526f\u4f5c\u7528\uff0c\u800c50%\u548c26%\u7684\u60a3\u8005\u62a5\u544a\u4e861\u7ea7\u548c3\u7ea7\u4e0d\u826f\u4e8b\u4ef6\uff08\u5305\u62ec\u53d1\u70ed\u3001\u76ae\u75b9\u548c\u5468\u56f4\u795e\u7ecf\u75bc\u75db\uff09\u3002\u5728\u4e00\u5e74\u7684\u89c2\u5bdf\u65f6\u95f4\u5185\uff0c38%\u7684\u60a3\u8005\u75c5\u60c5\u7a33\u5b9a\uff0c15%\u60a3\u8005\u90e8\u5206\u7f13\u89e3\uff0c47%\u7684\u60a3\u8005\u51fa\u73b0\u4e86\u8fdb\u5c55\u6027\u75be\u75c5\uff0c\u4e00\u5e74\u603b\u751f\u5b58\u7387\u4e3a74%\u3002<\/span><\/p>\n<section class=\"_editor\">\n<section style=\"margin: 20px 0% 10px;box-sizing: border-box;text-align: center;transform: translate3d(-10px, 0px, 0px);-webkit-transform: translate3d(-10px, 0px, 0px);-moz-transform: translate3d(-10px, 0px, 0px);-ms-transform: translate3d(-10px, 0px, 0px);-o-transform: translate3d(-10px, 0px, 0px);\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 2.0em;margin-right: -0.7em;overflow: hidden !important;box-sizing: border-box;transform: rotate(0deg);-webkit-transform: rotate(0deg);-moz-transform: rotate(0deg);-ms-transform: rotate(0deg);-o-transform: rotate(0deg);\"><\/section>\n<section style=\"display: inline-block;vertical-align: top;padding: 2px;border-radius: 4px;margin-top: 0.8em;background-color: rgba(197, 227, 211, 0.498039);box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: dashed;border-color: #ffffff;padding-right: 15px;padding-left: 15px;border-radius: 4px;line-height: 1.6;color: #36395e;font-size: 18px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"text-shadow: #feec75 1.73205px -1px 0px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">&nbsp; <strong>\u57fa\u56e0\u7597\u6cd5<\/strong>&nbsp;<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\u636eClarivate Analytics Cortellis\u6570\u636e\u5e93\u663e\u793a\uff0c\u76ee\u524d\u5904\u4e8e\u6ce8\u518c\u3001\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\u7684\u795e\u7ecf\u7cbe\u795e\u9886\u57df\u57fa\u56e0\u6cbb\u7597\u836f\uff08\u5305\u62ec\u6838\u82f7\u9178\u3001\u53cd\u4e49\u6838\u82f7\u9178\uff09\u5171\u8ba126\u4e2a\uff0c\u5360\u6240\u6709\u8be5\u9636\u6bb5\u57fa\u56e0\u7597\u6cd5\u768415%\uff08172\u4e2a\uff09\u3002\u5904\u4e8e\u6ce8\u518c\u9636\u6bb5\u7684\u67092\u4e2a\uff0c\u4e34\u5e8a\u2162\u671f\u67093\u4e2a\uff0c\u4e34\u5e8a\u2161\u671f\u670913\u4e2a\uff0c\u4e34\u5e8a\u2160\u671f\u67097\u4e2a\uff0c\u4e34\u5e8a\u6ce8\u518c\u9636\u6bb5\u7684\u67091\u4e2a\u3002\u4e34\u5e8a\u2161\u671f\u81f3\u6ce8\u518c\u9636\u6bb5\u7684\u57fa\u56e0\u7597\u6cd5\u8be6\u60c5\u89c1\u88682\u3002\u6d89\u53ca\u7684\u9002\u5e94\u75c7\u6709\u5bb6\u65cf\u6027\u6dc0\u7c89\u6837\u591a\u53d1\u6027\u795e\u7ecf\u75c5\u53d8\uff08FAP\uff09\u3001\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u3001\u4ea8\u5ef7\u987f\u821e\u8e48\u75c7\u3001\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7\u3001\u75bc\u75db\u7b49\u3002<\/span><\/p>\n<p style=\"text-align:center;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;\">\u88682\uff1a\u4e34\u5e8a\u2161\u671f\u81f3\u6ce8\u518c\u9636\u6bb5\u7684\u57fa\u56e0\u7597\u6cd5<\/p>\n<p style=\"text-align: center;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 0em;\"><img loading=\"lazy\" class=\"\"        height=\"1007\" style=\"border-width: 0px;border-style: initial;border-color: initial;width: 100%;height: auto;\" title=\"\u7ec6\u80de\u7597\u6cd5\u3001\u57fa\u56e0\u7597\u6cd5\uff1a\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u9886\u57df\u6cbb\u7597\u7a81\u7834\u6027\u8fdb\u5c55\" width=\"600\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533784668.jpeg\" alt=\"\u7ec6\u80de\u7597\u6cd5\u3001\u57fa\u56e0\u7597\u6cd5\uff1a\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u9886\u57df\u6cbb\u7597\u7a81\u7834\u6027\u8fdb\u5c55\">&nbsp;<\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\"><strong><span style=\"color: rgb(0, 102, 0);font-weight: normal;\">Inotersen\u548cPatisiran<\/span><\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\u5bb6\u65cf\u6027\u6dc0\u7c89\u6837\u591a\u53d1\u6027\u795e\u7ecf\u75c5\u53d8\uff08FAP\uff09\uff0c\u53c8\u79f0\u9057\u4f20\u6027\u8fd0\u7532\u72b6\u817a\u7d20\u86cb\u767d\uff08TTR\uff09\u4ecb\u5bfc\uff08hATTR\uff09\u6dc0\u7c89\u6837\u53d8\u662f\u4e00\u79cd\u7f55\u89c1\u7684TTR\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\u5e38\u67d3\u8272\u4f53\u663e\u6027\u9057\u4f20\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0cTTR\u7a81\u53d8\u53ef\u5bfc\u81f4\u7834\u574f\u795e\u7ecf\u7684\u8fd0\u7532\u72b6\u817a\u7d20\u86cb\u767d\uff08transthyretin\uff0cTTR\uff09\u7d2f\u79ef\uff0c\u5e76\u635f\u4f24\u8eab\u4f53\u5668\u5b98\u548c\u7ec4\u7ec7\uff0c\u5982\u5916\u56f4\u795e\u7ecf\u548c\u5fc3\u810f\uff0c\u5bfc\u81f4\u96be\u4ee5\u6cbb\u7597\u7684\u5916\u5468\u611f\u5b98\u795e\u7ecf\u75c5\u53d8\u3001\u81ea\u4e3b\u795e\u7ecf\u75c5\u53d8\u548c\u5fc3\u808c\u75c5\u3002\u5168\u7403\u5927\u6982\u67095\u4e07\u4eba\u60a3\u6709\u6b64\u75c5\u3002\u8be5\u75be\u75c5\u76ee\u524d\u5c1a\u65e0\u6709\u6548\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u9664\u4e86\u75be\u75c5\u65e9\u671f\u65f6\u7684\u809d\u79fb\u690d\u6cbb\u7597\uff0c\u552f\u4e00\u83b7\u5f97\u6279\u51c6\u7684\u6cbb\u7597\u65b9\u6848\u4ec5\u6709tafamidis\uff08\u5728\u6b27\u6d32\u3001\u65e5\u672c\u548c\u62c9\u4e01\u7f8e\u6d32\u7684\u67d0\u4e9b\u56fd\u5bb6\u83b7\u5f97\u6279\u51c6\uff09\u3002\u76ee\u524d\u6ce8\u518c\u548c\u4e34\u5e8a\u5728\u7814\u836f\u7269\u5171\u67097\u4e2a\uff0c\u5176\u4e2d\u57fa\u56e0\u836f\u7269\u67093\u4e2a\uff0c\u5206\u522b\u4e3aPatisiran\u3001Inotersen\u548cALN-TTR01\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">Patisiran\u662f\u7531Alnylam\u539f\u7814\u5e76\u6388\u6743\u8d5b\u8bfa\u83f2\uff08Sanofi\uff09\u5408\u4f5c\u8425\u9500\u7684\u4e8c\u4ee3\u5c0f\u5e72\u6270RNA\uff08siRNA\uff09\u836f\u7269\uff0c\u91c7\u7528Tekmira\u516c\u53f8\u7684\u8102\u8d28\u7eb3\u7c73\u6280\u672f\u9776\u5411\u8fd0\u7532\u72b6\u817a\u7d20\u86cb\u767d\u5bf9\u5e94\u7684mRNA\uff0c\u901a\u8fc7\u6c89\u9ed8\u8be5RNA\u7684\u8868\u8fbe\u6765\u963b\u788dTTR\u86cb\u767d\u751f\u6210\uff0c\u5e76\u6709\u52a9\u4e8e\u6e05\u9664\u5468\u56f4\u7ec4\u7ec7\u7684TTR\u6dc0\u7c89\u6837\u86cb\u767d\u6c89\u79ef\uff0c\u6062\u590d\u8fd9\u4e9b\u7ec4\u7ec7\u7684\u529f\u80fd\u6765\u6cbb\u7597hATTR\u6dc0\u7c89\u6837\u53d8\u3002Patisiran\u83b7\u5f97\u4e86FDA\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u5176\u539f\u7814\u516c\u53f8\u57282017\u5e7412\u6708\u5206\u522b\u5411FDA\u548cEMA\u63d0\u4ea4\u4e86NDA\u548cMAA\u7533\u8bf7\uff0c\u9884\u8ba1\u4eca\u5e748\u6708\u4efd\u4f1a\u6709\u5ba1\u6279\u6d88\u606f\u4f20\u51fa\u3002Cortellis\u6570\u636e\u9884\u6d4b\u51762022\u5e74\u9500\u552e\u989d\u5206\u522b\u4e3a8\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">Inotersen\u662fIonis\u5236\u836f\u516c\u53f8\u7814\u53d1\u7684\u7528\u4e8ehATTR\u6dc0\u7c89\u6837\u53d8\u6cbb\u7597\u7684\u53cd\u4e49\u6838\u82f7\u9178\u836f\u7269\uff0c\u5b83\u53ef\u4ee5\u6291\u5236\u6240\u6709TTR\u86cb\u767d\uff08\u5305\u62ec\u7a81\u53d8\u578b\u548c\u91ce\u751f\u578b\uff09\u7684\u751f\u6210\uff0c\u76ee\u524d\u5df2\u5411FDA\u548cEMA\u63d0\u4ea4\u4e86\u65b0\u836f\u7533\u8bf7\uff0c\u5e76\u88abFDA\u9881\u53d1\u4e86\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\u3002\u9884\u8ba1\u4eca\u5e74\u5341\u6708\u4efd\u4f1a\u6709\u5ba1\u6279\u6d88\u606f\u4f20\u51fa\uff0cCortellis\u6570\u636e\u9884\u6d4b\u51762022\u5e74\u9500\u552e\u989d\u4e3a4\u4ebf\u7f8e\u5143\u3002\u53e6\u5916\uff0cAlnylam\u548cIonis\u516c\u53f8\u5408\u4f5c\u5f00\u53d1\u7684TTR\u57fa\u56e0\u6291\u5236\u5242ALN-TTR01\uff08\u5be1\u6838\u82f7\u9178\uff09\u5728\u4e34\u5e8a\u2160\u671f\u8bd5\u9a8c\u4e2d\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\"><strong><span style=\"font-size: 16px;font-weight: normal;color: rgb(0, 102, 0);\">Golodirsen\u548cCasimersen<\/span><\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">Sarepta\u516c\u53f8\u662f\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u836f\u7269\u7814\u53d1\u7684\u9886\u5bfc\u8005\uff0c\u5176\u7814\u53d1\u7684Exondys 51\uff08eteplirsen\uff09\u662f\u76ee\u524d\u552f\u4e00\u83b7\u5f97\u6279\u51c6\u6cbb\u7597DMD\u7684\u65b0\u836f\u3002Sarepta\u7814\u53d1\u7ba1\u7ebf\u4e0a\u8fd8\u6709eteplirsen\u7c7b\u4f3c\u836fgolodirsen\u548ccasimersen\uff0c\u5df2\u63a8\u8fdb\u5230\u4e34\u5e8a\u2162\u671f\u7814\u7a76\u3002Golodirsen\u548ccasimersen\u5747\u4e3a\u53cd\u4e49\u5be1\u6838\u82f7\u9178\uff0c\u4e0eeteplirsen\u4e00\u6837\uff0c\u5747\u91c7\u7528\u4e86\u4e00\u79cd\u65b0\u9896\u7684\u78f7\u9170\u4e8c\u80fa\u5417\u5549\u4ee3\u5be1\u6838\u82f7\u9178\u548c\u5916\u663e\u5b50\u8df3\u8dc3\u6280\u672f\uff0c\u6765\u4fee\u590dmRNA\u7684\u9605\u8bfb\u6846\u5e76\u90e8\u5206\u7ea0\u6b63\u9057\u4f20\u7f3a\u9677\u3002\u5176\u4e2d\uff0cgolodirsen\u9002\u7528\u4e8e\u5b58\u5728\u7b2c53\u53f7\u5916\u663e\u5b50\u8df3\u8dc3\u7684\u60a3\u8005\uff0ccasimersen\u9002\u7528\u4e8e\u5b58\u5728\u7b2c45\u53f7\u5916\u663e\u5b50\u8df3\u8dc3\u7684\u60a3\u8005\u3002\u4e00\u9879\u4e3a\u671f\u4e24\u5e74\u7684\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08ESSENCE\uff09\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u7528\u4e8e\u8bc4\u4f30golodirsen\u548ccasimersen\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u76ee\u524dgolodirsen\u5728\u7f8e\u56fd\u6b63\u79ef\u6781\u5bfb\u6c42\u4e0a\u5e02\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">\u9664\u6b64\u4e4b\u5916\uff0cNippon Shinyaku\u516c\u53f8\u9488\u5bf953\u53f7\u5916\u663e\u5b50\u7a81\u53d8\u7684NS-065\u7b2c\u4e00\u4e09\u5171\uff08Daiichi Sankyo\uff09\u516c\u53f8\u9488\u5bf945\u53f7\u5916\u663e\u5b50\u7a81\u53d8\u7684DS-5141\u548cWAVE\u516c\u53f8\u9488\u5bf951\u53f7\u5916\u663e\u5b50\u7a81\u53d8\u7684WVE-210201\u5be1\u6838\u82f7\u9178\u7c7b\u836f\u7269\u5206\u522b\u5904\u4e8e\u4e34\u5e8a\u2161\u671f\u548c\u2160\u671f\u7814\u7a76\u4e2d\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\"><strong><span style=\"font-size: 16px;color: rgb(0, 102, 0);font-weight: normal;\">Brivoligide<\/span><\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 16px;\">Brivoligide\uff08AYX-1\uff09\u662fAdynxx\u516c\u53f8\u7814\u53d1\u7684\u901a\u8fc7\u6a21\u4effEGR-1\u6b63\u5e38\u7ed3\u5408\u7684\u57fa\u56e0\u7ec4\u5e8f\u5217\u800c\u963b\u65adEGR-1\u529f\u80fd\u7684DNA\u8bf1\u9975\u3002EGR1\u662f\u624b\u672f\u6216\u521b\u4f24\u65f6\u5728\u810a\u9ad3\u548c\u80cc\u6839\u795e\u7ecf\u8282\u4e2d\u77ac\u65f6\u4e0a\u8c03\u7684\u8f6c\u5f55\u56e0\u5b50\u3002\u4eca\u5e74\u56db\u6708\u4efd\u8be5\u516c\u53f8\u53d1\u5e03\u4e86brivoligide\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff08ADYX-004\uff09\u3002\u6b64\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u8bc4\u4f30\u4e86210\u540d\u63a5\u53d7\u5355\u4fa7\u5168\u819d\u5173\u8282\u7f6e\u6362\u672f\u7684\u53d7\u8bd5\u8005\u5355\u5242\u91cf\u672f\u524d\u670d\u7528brivoligide\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u6240\u6709\u53d7\u8bd5\u8005\u672f\u524d\u4e5f\u63a5\u53d7\u4e86\u6807\u51c6\u56f4\u624b\u672f\u671f\u75bc\u75db\u7ba1\u7406\u3002\u7ed3\u679c\u663e\u793a\uff0c\u867d\u7136\u6ca1\u80fd\u8fbe\u5230\u9884\u5b9a\u76847\uff5e28\u5929\u6b65\u884c\u75bc\u75db\u51cf\u8f7b\u7684\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\uff0c\u4f46\u5728\u75bc\u75db\u707e\u96be\u5316\u91cf\u8868\uff08PCS\uff09\u8bc4\u5206\u4e3a20\u6216\u66f4\u9ad8\u7684\u53d7\u8bd5\u8005\u4e2d\uff0cbrivoligide\u7ed9\u836f\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u4e0d\u4ec5\u6062\u590d\u81f3\u8f7b\u5ea6\u75bc\u75db\u7684\u65f6\u95f4\u7f29\u77ed\u4e8626\u5929\uff0841\u5929\u5bf9\u6bd415\u5929\uff09\uff0c\u800c\u4e14\u5bf9\u963f\u7247\u7c7b\u836f\u7269\u7684\u4f7f\u7528\u91cf\u4e5f\u51cf\u5c11\u4e8637%\u3002\u57fa\u4e8e\u8fd9\u4e9b\u7ed3\u679c\uff0cAdynxx\u8ba1\u5212\u542f\u52a8brivoligide\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;\">\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;\">1. Clarivate Analytics Cortellis\u6570\u636e\u5e93\uff0c\u68c0\u7d22\u65e5\u671f\uff1a2018\u5e747\u67086\u53f7.<\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;\">2. ClinicalTrials.gov, https:\/\/clinicaltrials.gov\/ct2\/home.<\/p>\n<p><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u521b\u836f\u7f51                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u6db5\u76d6600\u591a\u4e2a\u9002\u5e94\u75c7\uff0c\u8bf8\u591a\u75be\u75c5\u7684\u53d1\u75c5\u673a\u5236\u590d\u6742\u4e14\u5c1a\u672a\u63a2\u660e\uff0c\u836f\u7269\u7814\u53d1\u8fc7\u7a0b\u56f0\u96be\u91cd\u91cd\uff0c\u5982\u5728\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u9886\u57df [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":22895,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/22894"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=22894"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/22894\/revisions"}],"predecessor-version":[{"id":22904,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/22894\/revisions\/22904"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/22895"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=22894"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=22894"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=22894"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}