{"id":233,"date":"2018-07-03T01:00:00","date_gmt":"2018-07-27T06:18:16","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e4%bb%8e%e6%ad%a3%e5%a4%a7%e5%a4%a9%e6%99%b4%e7%9a%84%e6%81%a9%e6%9b%bf%e5%8d%a1%e9%9f%a6%e5%88%86%e6%95%a3%e7%89%87%e9%80%9a%e8%bf%87%e4%b8%80%e8%87%b4%e6%80%a7%e8%af%84%e4%bb%b7%e5%af%b9%e5%88%86\/"},"modified":"2018-07-27T14:18:18","modified_gmt":"2018-07-27T06:18:18","slug":"%e4%bb%8e%e6%ad%a3%e5%a4%a7%e5%a4%a9%e6%99%b4%e7%9a%84%e6%81%a9%e6%9b%bf%e5%8d%a1%e9%9f%a6%e5%88%86%e6%95%a3%e7%89%87%e9%80%9a%e8%bf%87%e4%b8%80%e8%87%b4%e6%80%a7%e8%af%84%e4%bb%b7%e5%af%b9%e5%88%86","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/233\/","title":{"rendered":"\u4ece\u6b63\u5927\u5929\u6674\u7684\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u5bf9\u5206\u6563\u7247\u7684\u601d\u8003"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"\"><img class=\"__bg_gif\"      style=\"color: rgb(51, 51, 51);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress7-1532672297.gif\" alt=\"\u4ece\u6b63\u5927\u5929\u6674\u7684\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u5bf9\u5206\u6563\u7247\u7684\u601d\u8003\" title=\"\u4ece\u6b63\u5927\u5929\u6674\u7684\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u5bf9\u5206\u6563\u7247\u7684\u601d\u8003\"  \/><\/p>\n<blockquote>\n<p style=\"\">\u672c\u6587\u6765\u81ea\u4e01\u9999\u56ed\u6218\u53cb\u201c\u6765\u5440\u6652\u4e2a\u592a\u9633\u201d\u3002<\/p>\n<p style=\"\">\u5982\u6709\u4fb5\u6743\uff0c\u8bf7\u8054\u7cfb\u5220\u9664\u3002<br  \/><\/p>\n<\/blockquote>\n<p style=\"\"><br  \/><\/p>\n<p style=\"\">\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\uff0c\u7a81\u7136\u89c9\u5f97\u4ee5\u524d\u5f88\u591a\u6539\u5242\u578b\u7684\u5206\u6563\u7247\u5f97\u6551\u4e86\u2026\u2026<br  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title=\"\u4ece\u6b63\u5927\u5929\u6674\u7684\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u5bf9\u5206\u6563\u7247\u7684\u601d\u8003\"  \/><\/p>\n<p style=\"\">2\u3001\u68c0\u7d22\u7f8e\u56fdUSP35\uff0c\u5bf9\u6eb6\u89e3\u5ea6\u7684\u5b9a\u4e49\u5982\u4e0b\uff1a<img class=\"\"     style=\"border-width: 0px;border-style: initial;border-color: initial;font-family: inherit;font-style: inherit;font-variant: inherit;font-weight: inherit;font-stretch: inherit;line-height: inherit;vertical-align: baseline;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress10-1532672297.jpg\" alt=\"\u4ece\u6b63\u5927\u5929\u6674\u7684\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u5bf9\u5206\u6563\u7247\u7684\u601d\u8003\" title=\"\u4ece\u6b63\u5927\u5929\u6674\u7684\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u5bf9\u5206\u6563\u7247\u7684\u601d\u8003\"  \/><\/p>\n<p style=\"\">3\u3001FDA\u6307\u5bfc\u539f\u5219\uff08Dissolution Testing of ImmediateRelease Solid Oral Dosage Forms\uff09\u4e2d\u6307\u51faBCS\u5206\u7c7b\u4e2d\u7684\u6eb6\u89e3\u5ea6\u662f\u6307\u836f\u7269\u5355\u6b21\u6700\u9ad8\u5242\u91cf\u5728250ml\u6eb6\u5242\u4e2d\u7684\u6eb6\u89e3\u5ea6\uff0c\u5b9a\u4e49\u5982\u4e0b\uff1a<\/p>\n<p style=\"\"><img class=\"\"     style=\"border-width: 0px;border-style: initial;border-color: initial;font-family: inherit;font-style: inherit;font-variant: inherit;font-weight: inherit;font-stretch: inherit;line-height: inherit;vertical-align: baseline;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532672297.jpg\" alt=\"\u4ece\u6b63\u5927\u5929\u6674\u7684\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u5bf9\u5206\u6563\u7247\u7684\u601d\u8003\" title=\"\u4ece\u6b63\u5927\u5929\u6674\u7684\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u5bf9\u5206\u6563\u7247\u7684\u601d\u8003\"  \/><\/p>\n<p style=\"\">\u7531\u4ee5\u4e0a\u4e09\u70b9\u53ef\u89c1\uff0c\u4e2d\u7f8e\u836f\u5178\u5bf9\u6eb6\u89e3\u5ea6\u7684\u5b9a\u4e49\u4e00\u81f4\uff0c\u4e14\u836f\u5178\u53ca\u6307\u5bfc\u539f\u5219\u4e2d\u5747\u6ca1\u5b9a\u4e49\u96be\u6eb6\u6027\u3002<\/p>\n<p style=\"\">&nbsp;\u4e8c\u3001\u5173\u4e8e\u6069\u66ff\u5361\u97e6\uff08Entecavir\uff09\u5206\u6563\u7247\u7684\u63a2\u8ba8<\/p>\n<p style=\"\">\u6069\u66ff\u5361\u97e6\u539f\u7814\u5242\u578b\u4e3a\u7247\u5242\u548c\u6df7\u60ac\u5242\uff0c\u7247\u5242\u7684\u89c4\u683c\u4e3a1mg\u548c0.5mg\u3002\u6b63\u5927\u5929\u6674\u836f\u4e1a\u96c6\u56e2\u80a1\u4efd\u6709\u9650\u516c\u53f8\u83b7\u6279\u7684\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u7684\u89c4\u683c\u4e3a0.5mg\u3002<\/p>\n<p style=\"\">1\u3001\u6839\u636eFDA\u8bf4\u660e\u4e66\u7684\u63cf\u8ff0\u6069\u66ff\u5361\u97e6\u6eb6\u89e3\u5ea6\u4e3a2.4mg\/ml\uff0c\u6eb6\u89e3\u5ea6\u4e3aslightly soluble\uff08\u5fae\u6eb6\uff09\u3002<\/p>\n<p style=\"\"><img class=\"\"     style=\"border-width: 0px;border-style: initial;border-color: initial;font-family: inherit;font-style: inherit;font-variant: inherit;font-weight: inherit;font-stretch: inherit;line-height: inherit;vertical-align: baseline;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress5-1532672297.png\" alt=\"\u4ece\u6b63\u5927\u5929\u6674\u7684\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u5bf9\u5206\u6563\u7247\u7684\u601d\u8003\" title=\"\u4ece\u6b63\u5927\u5929\u6674\u7684\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u5bf9\u5206\u6563\u7247\u7684\u601d\u8003\"  \/><\/p>\n<p style=\"\">2\u3001\u5728\u534e\u6d77\u836f\u4e1a\u63d0\u4ea4CDE\u7684\u6069\u66ff\u5361\u97e6\u539f\u6599\u836f\u8d44\u6599\u4e2d\uff0c\u6069\u66ff\u5361\u97e6\u6eb6\u89e3\u5ea6\u4e3a\u6781\u5fae\u6eb6\u89e3\u3002<\/p>\n<p style=\"\"><br  \/><\/p>\n<p style=\"\"><img class=\"\"     style=\"border-width: 0px;border-style: initial;border-color: initial;font-family: inherit;font-style: inherit;font-variant: inherit;font-weight: inherit;font-stretch: inherit;line-height: inherit;vertical-align: baseline;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress6-1532672297.jpg\" alt=\"\u4ece\u6b63\u5927\u5929\u6674\u7684\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u5bf9\u5206\u6563\u7247\u7684\u601d\u8003\" title=\"\u4ece\u6b63\u5927\u5929\u6674\u7684\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u5bf9\u5206\u6563\u7247\u7684\u601d\u8003\"  \/><\/p>\n<p style=\"\">3\u3001\u6587\u732e\uff08Leslie Z. Benet, BDDCS Applied to Over 900 Drugs.The AAPS Journal, Vol. 13, No. 4, December 2011. 519-547.\uff09\u4e2d\u6307\u51fa\uff0c\u6069\u66ff\u5361\u97e6\u5c5e\u4e8eBCDDS\u4e09\u7c7b\uff0c\u6eb6\u89e3\u5ea62.4mg\/ml\u3002<\/p>\n<p style=\"\"><img class=\"\"     style=\"border-width: 0px;border-style: initial;border-color: initial;font-family: inherit;font-style: inherit;font-variant: inherit;font-weight: inherit;font-stretch: inherit;line-height: inherit;vertical-align: baseline;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress10-1532672298.png\" alt=\"\u4ece\u6b63\u5927\u5929\u6674\u7684\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u5bf9\u5206\u6563\u7247\u7684\u601d\u8003\" title=\"\u4ece\u6b63\u5927\u5929\u6674\u7684\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\u5bf9\u5206\u6563\u7247\u7684\u601d\u8003\"  \/><\/p>\n<p style=\"\">\u7efc\u4e0a\u6240\u8ff0\uff0c\u6309\u7167\u6069\u66ff\u5361\u97e6\u7684\u5ba1\u8bc4\u5ba1\u6279\u5c3a\u5ea6\uff0c\u63a8\u6d4b\u96be\u6eb6\u6027\u81f3\u5c11\u5305\u542b\u5fae\u6eb6\uff0c\u6781\u5fae\u6eb6\u89e3\uff0c\u51e0\u4e4e\u4e0d\u6eb6\u6216\u4e0d\u6eb6\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u901a\u8fc7PMDA\u7684\u5ba1\u8bc4\u6587\u4ef6\u53ef\u4ee5\u5f97\u77e5\uff0c\u6069\u66ff\u5361\u97e6\u7247\u8840\u836f\u6d53\u5ea6\u65f6\u95f40.5-1.0\u5c0f\u65f6\u4e4b\u95f4\uff0c\u836f\u7269\u534a\u8870\u671f\u662f96.6\u5c0f\u65f6\u3002\u7531\u4e8e\u6069\u66ff\u5361\u97e6\u7684\u7279\u6b8aPK\u6027\u8d28\uff0c\u6240\u4ee5\u5206\u6563\u7247\u4e0e\u7247\u5242\u4e4b\u95f4\u751f\u7269\u7b49\u6548\u6027\u8fd8\u662f\u8f83\u6613\u901a\u8fc7\u3002<\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                                               <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u672c\u6587\u6765\u81ea\u4e01\u9999\u56ed\u6218\u53cb\u201c\u6765\u5440\u6652\u4e2a\u592a\u9633\u201d\u3002 \u5982\u6709\u4fb5\u6743\uff0c\u8bf7\u8054\u7cfb\u5220\u9664\u3002 \u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u901a\u8fc7\u4e00\u81f4\u6027\u8bc4\u4ef7\uff0c\u7a81\u7136\u89c9\u5f97\u4ee5\u524d\u5f88\u591a\u6539 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":234,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/233"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=233"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/233\/revisions"}],"predecessor-version":[{"id":243,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/233\/revisions\/243"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/234"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=233"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=233"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=233"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}