{"id":25046,"date":"2018-08-07T01:00:00","date_gmt":"2018-08-09T03:32:49","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e4%bb%8eegfr%e5%88%b0alk%ef%bc%8c%e8%b4%9d%e8%be%be%e8%8d%af%e4%b8%9a%e5%9d%90%e7%a8%b3%e9%9d%9e%e5%b0%8f%e9%9d%b6%e5%90%91%e9%a2%86%e5%a4%b4%e7%be%8a\/"},"modified":"2018-08-09T11:32:52","modified_gmt":"2018-08-09T03:32:52","slug":"%e4%bb%8eegfr%e5%88%b0alk%ef%bc%8c%e8%b4%9d%e8%be%be%e8%8d%af%e4%b8%9a%e5%9d%90%e7%a8%b3%e9%9d%9e%e5%b0%8f%e9%9d%b6%e5%90%91%e9%a2%86%e5%a4%b4%e7%be%8a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/25046\/","title":{"rendered":"\u4eceEGFR\u5230ALK\uff0c\u8d1d\u8fbe\u836f\u4e1a\u5750\u7a33\u201c\u975e\u5c0f\u9776\u5411\u201d\u9886\u5934\u7f8a"},"content":{"rendered":"
\n

 \u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug \u25b2 \u6dfb\u52a0\u5173\u6ce8<\/span><\/span><\/span><\/p>\n


<\/p>\n

\u76ee\u524d\uff0c\u8d1d\u8fbe\u836f\u4e1a\u901a\u8fc7\u9879\u76ee\u5f15\u8fdb&\u81ea\u4e3b\u7814\u53d1\uff0c\u6784\u5efa\u4e86\u4e30\u5bcc\u7684\u4ee5\u6297\u80bf\u7624\u836f\u4e3a\u6838\u5fc3\u7684\u521b\u65b0\u836f\u68af\u961f\uff0c\u5176\u4e2d<\/span>\u6069\u6c99\u66ff\u5c3c<\/span><\/strong>\u7528\u4e8e ALK \u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e00\u7ebf\u6cbb\u7597\uff0c\u5904\u4e8e\u5168\u7403\u591a\u4e2d\u5fc3 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b\u6069\u6c99\u66ff\u5c3c\u7528\u4e8e ALK \u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e8c\u7ebf\u6cbb\u7597\uff0c\u5904\u4e8e\u56fd\u5185 II \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b<\/span>Vorolanib <\/strong><\/span>\u7528\u4e8e\u80be\u7ec6\u80de\u764c\u6cbb\u7597\uff0c\u5904\u4e8e\u56fd\u5185 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b Vorolanib \u7528\u4e8e\u6e7f\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08WAMD\uff09\u6cbb\u7597\uff0c\u5904\u4e8e\u56fd\u5185 I \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1bVorolanib \u7528\u4e8e\u665a\u671f\u80c3\u764c\u7684\u6cbb\u7597\uff0c\u5904\u4e8e\u56fd\u5185 Ib \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b<\/span>\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f<\/strong><\/span>\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6cbb\u7597\uff0c\u5904\u4e8e\u56fd\u5185 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b<\/span>\u5e15\u5c3c\u5355\u6297<\/strong><\/span>\uff0851%\u63a7\u80a1\u5b50\u516c\u53f8\u8d1d\u8fbe\u5b89\u8fdb\uff09\u7528\u4e8e\u7ed3\u76f4\u80a0\u764c\u7684\u6cbb\u7597\uff0c\u5904\u4e8e\u56fd\u5185 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b\u6b64\u5916\uff0c\u516c\u53f8\u8fd8\u6709\u4f17\u591a\u521b\u65b0\u836f\u5904\u4e8e I \u671f\u4e34\u5e8a\u8bd5\u9a8c\u548c\u4e34\u5e8a\u524d\u7814\u7a76\u9636\u6bb5\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u4eceEGFR\u5230ALK\uff0c\u8d1d\u8fbe\u836f\u4e1a\u5750\u7a33\u201c\u975e\u5c0f\u9776\u5411\u201d\u9886\u5934\u7f8a\"<\/p>\n


<\/p>\n

1<\/strong><\/span>\u57c3\u514b\u66ff\u5c3c<\/span><\/strong><\/span><\/h2>\n


<\/span><\/strong><\/span><\/p>\n

\u57c3\u514b\u66ff\u5c3c<\/span>\u4e8e2011\u5e746\u67087\u65e5\u83b7\u4e2d\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08CFDA\uff09\u6279\u51c6\u4e0a\u5e02\uff0c\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\u836f\u7269\u7528\u4e8e\u80bf\u7624\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\uff0c\u6709\u56fd\u4ea7\u6613\u745e\u6c99\u4e4b\u79f0\u3002<\/span><\/p>\n

<\/span><\/p>\n

\"\u4eceEGFR\u5230ALK\uff0c\u8d1d\u8fbe\u836f\u4e1a\u5750\u7a33\u201c\u975e\u5c0f\u9776\u5411\u201d\u9886\u5934\u7f8a\"<\/p>\n

\u57c3\u514b\u66ff\u5c3c\u4e00\u79cd\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u540e\u8005\u5728\u5404\u79cd\u764c\u75c7\u4e2d\u9ad8\u8868\u8fbe\u6216\u8005\u7a81\u53d8\uff0c\u9020\u6210\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def\u5f02\u5e38\u6fc0\u6d3b\uff0c\u8be5\u836f\u80fd\u4e0eEGFR\u7684ATP\u4f4d\u70b9\u7ed3\u5408\uff0c\u4ece\u800c\u6291\u5236\u5176\u6d3b\u6027\u3002<\/span>\u968f\u7740\u57c3\u514b\u66ff\u5c3c\u7b49\u54c1\u79cd\u7eb3\u5165\u533b\u4fdd\uff0c\u56fd\u5185\u975e\u5c0f\u7ec6\u80de\u80ba\u764c EGFR \u66ff\u5c3c\u7c7b\u5e02\u573a\u7a7a \u95f4\u8d85 116 \u4ebf\u5143\u3002\u57c3\u514b\u66ff\u5c3c\u6709\u9500\u552e\u4f18\u52bf\u3001\u4ef7\u683c\u4f18\u52bf\u548c\u533b\u4fdd\u4f18\u52bf\uff0c\u6211\u4eec\u9884\u8ba1 \u5373\u4f7f\u5409\u975e\u66ff\u5c3c\u548c\u5384\u6d1b\u66ff\u5c3c\u4eff\u5236\u836f\u9646\u7eed\u4e0a\u5e02\u3001\u5965\u5e0c\u66ff\u5c3c\u8fdb\u5165\u4e00\u7ebf\u7528\u836f\uff0c\u57c3 \u514b\u66ff\u5c3c\u4ecd\u5c06\u83b7\u5f97 15%\u4ee5\u4e0a\u5e02\u573a\u4efd\u989d\uff0c\u5cf0\u503c\u9500\u552e\u6709\u671b\u8d85\u8fc7 17 \u4ebf\u5143\u3002<\/span>
<\/p>\n


<\/span><\/p>\n

2<\/strong><\/span>\u6069\u6c99\u66ff\u5c3c<\/span><\/strong><\/span><\/h2>\n


<\/span><\/p>\n

\u5148\u8ba4\u8bc6\u4e00\u4e0b\u5927\u540d\u9f0e\u9f0e\u7684\u963f\u6765\u66ff\u5c3c<\/span><\/strong><\/p>\n

\u5728\u4eca\u5e746\u6708\u53ec\u5f00\u76842018\u5e74ASCO\u5e74\u4f1a\u4e0a\uff0c\u7814\u7a76\u4eba\u5458\u66f4\u65b0\u4e86ALEX\u7814\u7a76\u7684\u7ed3\u679c\uff0c\u8fd9\u662f\u4e00\u4e2a\u5168\u7403\u591a\u4e2d\u5fc3\u7684\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e3b\u8981\u76ee\u7684\u662f\u6bd4\u8f83\u963f\u6765\u66ff\u5c3c\u8ddf\u514b\u5511\u66ff\u5c3c\u5230\u5e95\u8c01\u7684\u6548\u679c\u66f4\u597d\u3002\u7814\u7a76\u4ece2014\u5e74\u5c31\u5f00\u59cb\uff0c\u5171\u7eb3\u5165303\u4f4d\u521d\u8bca\u7684ALK+\u975e\u5c0f\u80ba\u764c\u60a3\u8005\uff1a152\u4f4d\u63a5\u53d7\u963f\u6765\u66ff\u5c3c\uff0c\u53e3\u670d600mg\uff0c\u6bcf\u5929\u4e24\u6b21\uff1b151\u4f4d\u63a5\u53d7\u514b\u5511\u66ff\u5c3c\uff0c\u53e3\u670d250mg\uff0c\u6bcf\u5929\u4e24\u6b21\u3002<\/span><\/p>\n

\"\u4eceEGFR\u5230ALK\uff0c\u8d1d\u8fbe\u836f\u4e1a\u5750\u7a33\u201c\u975e\u5c0f\u9776\u5411\u201d\u9886\u5934\u7f8a\"<\/span><\/p>\n

\u4e2d\u4f4dPFS\u8fd1\u4e09\u5e74\uff0c \u957f\u671f\u751f\u5b58\u4e0d\u662f\u68a6\u7ecf\u8fc7\u4e24\u5e74\u968f\u8bbf\uff0c\u963f\u6765\u66ff\u5c3c\u7ec4\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5386\u53f2\u6027\u7684\u8fbe\u5230\u4e8634.8\u4e2a\u6708\uff0c\u800c\u514b\u5511\u66ff\u5c3c\u7ec4\u53ea\u670910.9\u4e2a\u6708\uff0c\u963f\u6765\u66ff\u5c3c\u63d0\u9ad8\u4e86\u8db3\u8db33\u500d\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff0c\u8fd9\u610f\u5473\u774050%\u7684\u764c\u75c7\u60a3\u8005\u53ef\u4ee5\u8f7b\u8f7b\u677e\u677e\u5b9e\u73b0\u8fd13\u5e74\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\uff0c\u5c31\u662f\u8ddf\u6b63\u5e38\u4eba\u4e00\u6837\u751f\u6d3b\u3002<\/span><\/p>\n


<\/p>\n

\u8d1d\u8fbe\u836f\u4e1a\u7684\u7b2c\u4e8c\u4e2a\u91cd\u78c5\u54c1\u79cd\u5fc5\u5c06\u662f<\/span>\u6069\u6c99\u66ff\u5c3c<\/strong><\/span>\u3002\u56fd\u9645\u5e02\u573a\u65b9\u9762\uff0c \u6069\u6c99\u66ff\u5c3c\u76ee\u524d\u5904\u4e8e ALK \u7a81\u53d8\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e00\u7ebf\u6cbb\u7597\u5168\u7403 III \u671f\u4e34\u5e8a\uff0c \u7597\u6548\u6709\u671b\u770b\u9f50\u963f\u6765\u66ff\u5c3c\uff0c\u9884\u8ba1\u5c06\u548c\u963f\u6765\u66ff\u5c3c\u3001Brigatinib \u7b49\u5171\u540c\u7ade\u4e89\u56fd\u9645\u5e02\u573a\uff1b\u56fd\u5185\u5e02\u573a\u65b9\u9762\uff0c\u6069\u6c99\u66ff\u5c3c\u56fd\u5185\u5904\u4e8e\u4e8c\u7ebf\u6cbb\u7597 II \u671f\u4e34\u5e8a\uff0c\u501f\u52a9\u8d1d\u8fbe\u6210\u719f\u7684\u80ba\u764c\u4ea7\u54c1\u9500\u552e\u6e20\u9053\u5feb\u901f\u653e\u91cf\uff0c\u56fd\u5185\u5cf0\u503c\u9500\u552e\u6709\u671b\u8d85\u8fc7 20 \u4ebf\u5143\uff0c \u590d\u5236\u57c3\u514b\u66ff\u5c3c\u7684\u6210\u529f\uff1b<\/span><\/p>\n


<\/p>\n

3<\/strong><\/span>\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f<\/span><\/strong><\/span><\/h2>\n


<\/p>\n

EGFR \u548c ALK \u7a81\u53d8\u9634\u6027\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff0c\u7ea6\u5360\u4e9a\u6d32\u60a3\u8005\u7684 53% \u5de6\u53f3\u3002\u6839\u636e NCCN \u548c\u56fd\u5185\u6307\u5357\uff0cEGFR \u548c ALK \u7a81\u53d8\u9634\u6027\u7684\u975e\u5c0f\u7ec6\u80de\u80ba \u764c\u4e00\u7ebf\u6cbb\u7597\u9776\u5411\u836f\u5305\u62ec\u6297 PD-1 \u5355\u6297\u548c\u8d1d\u4f10\u73e0\u5355\u6297\uff1b\u4e8c\u7ebf\u6cbb\u7597\u5305\u62ec\u6297 PD-1\/PD-L1 \u5355\u6297\u548c\u6297 VEGFR2 \u5355\u6297\uff1b\u4e09\u7ebf\u6cbb\u7597\u5305\u62ec\u6297 VEGFR \u6291\u5236\u5242 \u7b49\u3002\u8d1d\u8fbe\u836f\u4e1a\u7684<\/span>\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f<\/span><\/strong>\u5904\u4e8e III \u671f\u4e34\u5e8a\u8bd5\u9a8c\u3001\u6297 VEGFR \u6291\u5236\u5242 Vorolanib \u4e8c\u7ebf\u6cbb\u7597\u80be\u7ec6\u80de\u764c\u5904\u4e8e III \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u672a\u6765\u6709\u671b\u8fdb\u4e00\u6b65\u62d3\u5c55 \u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u9002\u5e94\u75c7\u3002<\/span><\/p>\n

\"\u4eceEGFR\u5230ALK\uff0c\u8d1d\u8fbe\u836f\u4e1a\u5750\u7a33\u201c\u975e\u5c0f\u9776\u5411\u201d\u9886\u5934\u7f8a\"<\/span><\/strong><\/p>\n

\u8d1d\u4f10\u73e0\u5355\u6297\u662f\u7f57\u6c0f\uff08\u57fa\u56e0\u6cf0\u514b\uff09\u7814\u53d1\u7684\u6297\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u4eba\u6e90\u5316 \u5355\u514b\u9686\u6297\u4f53\uff0c\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7b49\u5404\u7c7b\u8f6c\u79fb\u6027\u764c \u75c7\u30022004\u5e742\u670826\u65e5\u83b7\u5f97 FDA \u6279\u51c6\u4e0a\u5e02\uff0c\u5e76\u4e8e 2010\u5e742\u670826\u65e5\u8fdb\u5165\u4e2d\u56fd\uff0c\u5546\u54c1\u540d Avastin\/\u5b89\u7ef4\u6c40\u3002\u76ee\u524d\u56fd\u5185\u6709 6 \u5bb6\u4f01\u4e1a\u8d1d\u4f10\u73e0\u5355\u6297\u8fdb\u5165 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u4e2d<\/span>\u9f50\u9c81\u5236\u836f\u3001\u4fe1\u8fbe\u751f\u7269\u3001\u6052\u745e\u533b\u836f\u3001\u6b63\u5927\u5929\u6674\u548c\u8d1d\u8fbe\u836f\u4e1a<\/span><\/strong>\u5747\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u9002\u5e94\u75c7\uff1b<\/span>\u590d\u5b8f\u6c49\u9716<\/strong><\/span>\u4ea7\u54c1\u4e3a\u7ed3\u76f4\u80a0\u764c\u9002\u5e94\u75c7\u3002<\/span><\/p>\n


<\/span><\/strong><\/p>\n

\"\u4eceEGFR\u5230ALK\uff0c\u8d1d\u8fbe\u836f\u4e1a\u5750\u7a33\u201c\u975e\u5c0f\u9776\u5411\u201d\u9886\u5934\u7f8a\"<\/p>\n

<\/span><\/strong>
<\/p>\n

4<\/strong><\/span>CDK\u6291\u5236<\/span><\/strong><\/span>\u5242BPI-16350<\/span><\/strong><\/span><\/h2>\n


<\/p>\n

\u8d1d\u8fbe\u836f\u4e1a\u81ea\u4e3b\u7814\u53d1\u7684<\/span>BPI-16350<\/strong><\/span>\u80f6\u56ca\u7528\u4e8e\u6cbb\u7597\u4e73\u817a\u764c\u7684\u836f\u54c1\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u4e8e<\/span>2\u6708<\/span>1\u65e5\u83b7\u5f97<\/span>FDA\u53d7\u7406\u3002<\/span><\/span>BPI-16350<\/span>\u662f\u8d1d\u8fbe\u81ea\u4e3b\u7814\u53d1\u7684\u6297\u80bf\u7624\u65b0\u836f\uff0c\u9488\u5bf9\u7684\u9776\u70b9\u4e3a\u7ec6\u80de\u5468\u671f\u86cb\u767d\u4f9d\u8d56\u6027\u6fc0\u9176<\/span>4\/6<\/span>\uff08<\/span>CDK4\/6<\/span>\uff09\uff0c\u62df\u5355\u836f\u6216\u4e0e\u6fc0\u7d20\u7597\u6cd5\u8054\u5408\uff0c\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u548c\u4eba\u7c7b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\u9634\u6027(HR \u9633\u6027\/HER2 \u9634\u6027) \u7684\u7edd\u7ecf\u540e\u665a\u671f\u6216\u8f6c\u79fb\u4e73\u817a\u764c\u60a3\u8005\uff0c\u8fd8\u53ef\u7528\u4e8eRb+\u7684\u5176\u4ed6\u764c\u75c7\u7684\u4e00\u3001\u4e8c\u7ebf\u6216\u8054\u5408\u6cbb\u7597\u3002<\/span><\/span><\/p>\n


<\/p>\n

\u5df2\u4e0a\u5e02CDK4\/6\u6291\u5236\u5242<\/span><\/strong><\/h2>\n


<\/p>\n\n\n\n\n\n\n
\n

\u836f\u54c1\u540d\u79f0<\/span><\/p>\n<\/td>\n

\n

\u7814\u53d1\u516c\u53f8<\/span><\/p>\n<\/td>\n

\n

\u9776\u70b9<\/span><\/p>\n<\/td>\n

\n

\u4e0a\u5e02\u65f6\u95f4<\/span><\/p>\n<\/td>\n

\n

\u9002\u5e94\u75c7<\/span><\/p>\n<\/td>\n

\n

2017\u9500\u552e\u989d\uff08\u4ebf\u7f8e\u5143\uff09<\/span><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Palbociclib<\/span><\/p>\n<\/td>\n

\n

\u8f89\u745e<\/span><\/p>\n<\/td>\n

\n

CDK 4\/6<\/span><\/p>\n<\/td>\n

\n

2015\/2\/3<\/span><\/p>\n<\/td>\n

\n

\u4e73\u817a\u764c<\/span><\/p>\n<\/td>\n

\n

31.26<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Ribociclib<\/span><\/p>\n<\/td>\n

\n

\u8bfa\u534e<\/span><\/p>\n<\/td>\n

\n

CDK 4\/6<\/span><\/p>\n<\/td>\n

\n

2017\/3\/13<\/span><\/p>\n<\/td>\n

\n

\u4e73\u817a\u764c<\/span><\/p>\n<\/td>\n

\n

0.76<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Abemaciclib<\/span><\/p>\n<\/td>\n

\n

\u793c\u6765<\/span><\/p>\n<\/td>\n

\n

CDK 4\/6<\/span><\/p>\n<\/td>\n

\n

2017\/9\/28<\/span><\/p>\n<\/td>\n

\n

\u4e73\u817a\u764c\u53ca\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/span><\/p>\n<\/td>\n

\n

0.21<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n


<\/span><\/p>\n

\u4eca\u5929\uff01\u7ec8\u4e8e\uff01<\/span><\/strong>\u8f89\u745e\u5236\u836f\u516c\u53f8\u5ba3\u5e03\uff0c<\/span>CFDA\u6b63\u5f0f\u6279\u51c6\u4e86<\/span>\u9996\u4e2aCDK4\/6\u6291\u5236\u5242\u7231\u535a\u65b0(\u54cc\u67cf\u897f\u5229)<\/span><\/strong><\/span>\u7684\u4e2d\u56fd\u4e0a\u5e02\u7533\u8bf7\u3002\u7528\u4e8e<\/span>\u4e00\u7ebf\u8054\u5408\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\u6cbb\u7597<\/span><\/strong>\u7edd\u7ecf\u540e\u5973\u6027\uff0c<\/span>\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff08HR+\uff09\u3001HER2-\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c<\/span><\/strong>\u3002<\/span>\u6210\u4e3a\u5168\u7403\u7b2c87\u4e2a\u83b7\u5f97\u6279\u51c6\u7684\u56fd\u5bb6\uff01<\/span><\/span>\u76ee\u524d\uff0cFDA\u5171\u6279\u51c6\u4e863\u4e2aCDK 4\/6\u6291\u5236\u5242\u836f\u7269\u5373\u8f89\u745e\u7684Palbociclib\u3001\u8bfa\u534e\u7684Ribociclib\u4ee5\u53ca\u793c\u6765\u7684Abemaciclib\uff0c\u7136\u800c\u8fd9\u4e09\u79cd\u836f\u7269\u5747\u5c1a\u672a\u5728\u56fd\u5185\u83b7\u6279\u4e0a\u5e02\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u4eceEGFR\u5230ALK\uff0c\u8d1d\u8fbe\u836f\u4e1a\u5750\u7a33\u201c\u975e\u5c0f\u9776\u5411\u201d\u9886\u5934\u7f8a\"<\/p>\n


<\/span><\/strong><\/h2>\n

CDK4\/6\u6291\u5236\u5242\u7814\u7a76\u73b0\u72b6<\/span><\/strong><\/h2>\n


<\/p>\n\n\n\n\n\n\n
\n

\u836f\u54c1\u540d\u79f0<\/span><\/p>\n<\/td>\n

\n

\u7814\u53d1\u516c\u53f8<\/span><\/p>\n<\/td>\n

\n

\u7814\u53d1\u72b6\u6001<\/span><\/p>\n<\/td>\n

\n

\u9002\u5e94\u75c7<\/span><\/p>\n<\/td>\n

\n

\u836f\u54c1\u53d7\u7406\u53f7<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

SHR6390<\/span><\/p>\n<\/td>\n

\n

\u6052\u745e<\/span><\/p>\n<\/td>\n

\n

\u4e34\u5e8a\u4e00\u671f<\/span><\/p>\n<\/td>\n

\n

\u4e73\u817a\u764c<\/span><\/p>\n<\/td>\n

\n

CXHL1400439<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Birociclib<\/span><\/p>\n<\/td>\n

\n

\u56db\u73af\u533b\u836f<\/span><\/p>\n<\/td>\n

\n

\u83b7\u6279\u4e34\u5e8a<\/span><\/p>\n<\/td>\n

\n

\u4e73\u817a\u764c\u3001\u6076\u6027\u8111\u764c\u7b49<\/span><\/p>\n<\/td>\n

\n

CXHL1600275<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

BPI-16350<\/span><\/p>\n<\/td>\n

\n

\u8d1d\u8fbe\u836f\u4e1a<\/span><\/p>\n<\/td>\n

\n

\u4e34\u5e8a\u7533\u8bf7\u83b7\u53d7\u7406<\/span><\/p>\n<\/td>\n

\n

\u4e73\u817a\u764c<\/span><\/p>\n<\/td>\n

\n

CXHL1800007  <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n


<\/span><\/p>\n

5<\/strong><\/span>\u603b\u7ed3<\/span><\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/h2>\n


<\/p>\n

\u8d1d\u8fbe\u836f\u4e1a\u4ee5\u521b\u65b0\u836f\u4e3a\u6838\u5fc3\uff0c\u662f\u56fd\u5185\u4e3a\u6570\u4e0d\u591a\u7684\u540c\u65f6\u62e5\u6709\u56fd\u9645\u6c34\u5e73\u7684\u7814\u53d1\u6807\u51c6\u548c\u56fd\u5185\u4e00\u6d41\u7684\u5b66\u672f\u63a8\u5e7f\u7684\u516c\u53f8\u3002\u516c\u53f8\u6df1\u8015\u80bf\u7624\uff0c\u5c24\u5176\u662f\u53d1\u75c5\u7387\u6700\u9ad8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u9886\u57df\uff0c\u7855\u679c\u7d2f\u7d2f\u3002<\/span><\/p>\n

\u5f53\u7136\uff0c\u56fd\u5185\u7684\u5176\u5b83\u521b\u65b0\u836f\u7269\u516c\u53f8\u540c\u6837\u5b9e\u529b\u96c4\u539a\uff0c\u4fe1\u8fbe\u751f\u7269\u3001\u518d\u9f0e\u533b\u836f\u3001\u5357\u4eac\u4f20\u5947\u7b49\u90fd\u4e0d\u7f3a\u660e\u661f\u54c1\u79cd\u3002\u5c0f\u7f16\u4e0b\u6b21\u4e00\u5e76\u4ecb\u7ecd\u54e6\uff01\uff01\uff01<\/span>
<\/p>\n


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\u5b66\u5982\u9006\u6c34\u884c\u821f\uff0c\u4e0d\u8fdb\u5219\u9000\uff1b<\/span><\/p>\n

\u5fc3\u4f3c\u5e73\u539f\u8d70\u9a6c\uff0c\u6613\u653e\u96be\u6536\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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<\/p>\n

\n
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\u884c\u821fDrug<\/span><\/p>\n<\/section>\n

\n

\u6bcf\u65e5\u66f4\u65b0 \u6b22\u8fce\u8ba2\u9605+<\/span><\/p>\n

\n


<\/p>\n

\"\u4eceEGFR\u5230ALK\uff0c\u8d1d\u8fbe\u836f\u4e1a\u5750\u7a33\u201c\u975e\u5c0f\u9776\u5411\u201d\u9886\u5934\u7f8a\"<\/p>\n<\/section>\n


<\/p>\n

\u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u884c\u821fDrug <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

 \u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug \u25b2 \u6dfb\u52a0\u5173\u6ce8 \u76ee\u524d\uff0c\u8d1d\u8fbe\u836f\u4e1a\u901a\u8fc7\u9879\u76ee\u5f15\u8fdb& […]<\/p>\n","protected":false},"author":1,"featured_media":25047,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/25046"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=25046"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/25046\/revisions"}],"predecessor-version":[{"id":25059,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/25046\/revisions\/25059"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/25047"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=25046"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=25046"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=25046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}