{"id":25745,"date":"2018-08-07T01:00:00","date_gmt":"2018-08-09T03:38:38","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e5%9c%a8%e6%96%b0%e8%8d%af%e5%8f%91%e7%8e%b0%e9%98%b6%e6%ae%b5%e7%9a%84dmpk%e7%ad%9b%e9%80%89%e6%96%b9%e6%b3%95%e5%8f%8a%e8%af%84%e4%bb%b7%e7%ad%96%e7%95%a5\/"},"modified":"2018-08-09T11:38:42","modified_gmt":"2018-08-09T03:38:42","slug":"%e5%9c%a8%e6%96%b0%e8%8d%af%e5%8f%91%e7%8e%b0%e9%98%b6%e6%ae%b5%e7%9a%84dmpk%e7%ad%9b%e9%80%89%e6%96%b9%e6%b3%95%e5%8f%8a%e8%af%84%e4%bb%b7%e7%ad%96%e7%95%a5","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/25745\/","title":{"rendered":"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: justify;line-height: 1.75em;\">\u836f\u4ee3\u52a8\u529b\u5b66\uff08Drug metabolism and Pharmacokinetics\uff09\u662f\u5b9a\u91cf\u7814\u7a76\u836f\u7269\u5728\u751f\u7269\u4f53\u5185\u5438\u6536\u3001\u5206\u5e03\u3001\u6392\u6cc4\u548c\u4ee3\u8c22\u89c4\u5f8b\u7684\u4e00\u95e8\u5b66\u79d1\uff0c\u662f\u65b0\u836f\u8bbe\u8ba1\u548c\u5f00\u53d1\u5404\u4e2a\u9636\u6bb5\u7684\u5173\u952e\u7ec4\u6210\u90e8\u5206\u3002\u672c\u6587\u4e3b\u8981\u4ecb\u7ecd\u4e86\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5DMPK\u9ad8\u901a\u91cf\u7b5b\u9009\u65b9\u6cd5\uff0c\u53ca\u5206\u4eab\u5404\u5927\u5236\u836f\u4f01\u4e1a\u7684DMPK\u7b5b\u9009\u8bc4\u4ef7\u7b56\u7565\u3002<\/p>\n<p style=\"line-height:150%;\"><span style=\"font-size:16px;line-height:150%;font-family:\u5b8b\u4f53;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"color: rgb(217, 33, 66);\"><strong>\u65b0\u836f\u7814\u53d1\u5931\u8d25\u5206\u6790<\/strong><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u636eDaniela Schuster\u548cChristian Laggner\u7edf\u8ba1\uff08\u56fe1\uff09[1]\uff0c\u57281964-1985\u5e74\u671f\u95f4\uff0cDMPK\u5bfc\u81f4\u7684\u5931\u8d25\u63a5\u8fd140%\u3002\u81ea20\u4e16\u7eaa80\u5e74\u4ee3\u8d77\uff0c\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u53d7\u5230\u8de8\u56fd\u5236\u836f\u516c\u53f8\u7684\u9ad8\u5ea6\u91cd\u89c6\uff0c\u5e76\u8d8a\u6765\u8d8a\u65e9\u7684\u4ecb\u5165\u5230\u836f\u7269\u8bbe\u8ba1\u3001\u7b5b\u9009\u548c\u8bc4\u4ef7\u4e2d\u3002\u6570\u636e\u8bc1\u660e\uff0c\u8fd9\u90e8\u5206\u6295\u8d44\u662f\u503c\u5f97\u7684\uff0c\u57281992-2002\u5e74\u671f\u95f4\uff0c\u4e34\u5e8a\u2160\u3001\u2161\u548c\u2162\u671f\u56e0DMPK\u5bfc\u81f4\u7ec8\u6b62\u7684\u5206\u522b\u4e3a14%\u300117%\u548c4%\uff08\u56fe2\uff09[1]\u3002Ismail Kola \u548c John Landis\u7684\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff08\u56fe3\uff09[2] 1991-2000\u5e74\u5728\u65b0\u836f\u5f00\u53d1\u9636\u6bb5\uff0c\u56e0DMPK\u5bfc\u81f4\u7684\u5931\u8d25\u7387\u4ece\u8fd140%\u964d\u4f4e\u81f310%\u5de6\u53f3\u3002\u968f\u7740DMPK\u6280\u672f\u7684\u53d1\u5c55\u548c\u5e94\u7528\uff0c\u57282008-2010\u5e74\u4e34\u5e8a\u2161\u671f\u56e0DMPK\u5bfc\u81f4\u7684\u5931\u8d25\u7387\u8fdb\u4e00\u6b65\u964d\u4f4e\u81f31%(\u56fe4)[3,4]\uff0c\u800c2011-2015\u5e74\u7684\u6570\u636e\u663e\u793a\u4e34\u5e8a\u2161\u671f\u548c\u2162\u671f\u6ca1\u6709\u56e0DMPK\u5bfc\u81f4\u7684\u5931\u8d25[5,6]\u3002\u8fd9\u4e9b\u6570\u636e\u5145\u5206\u8bf4\u660e\u4e86DMPK\u5728\u65b0\u836f\u7814\u53d1\u4e2d\u7684\u91cd\u8981\u6027\uff0c\u5728\u65e9\u671f\u8fdb\u884cDMPK\u7814\u7a76\u53ef\u907f\u514d\u540e\u671fDMPK\u5bfc\u81f4\u7684\u5931\u8d25\uff0c\u964d\u4f4e\u540e\u671f\u5f00\u53d1\u98ce\u9669\u548c\u8d39\u7528\u3002<\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress3-1533785919.jpg\" alt=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\" title=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\"  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\">\u56fe1. 1964-1985\u5e74\uff0c\u65b0\u836f\u7814\u53d1\u5931\u8d25\u7684\u539f\u56e0\uff08n=198\uff09<\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><br  \/><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533785919.jpg\" alt=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\" title=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\"  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\">\u56fe2. 1992-2002\u5e74\uff0c\u836f\u7269\u5728\u4e34\u5e8a\u2160\uff08\u5de6\uff09\u3001\u2161\uff08\u4e2d\uff09\u3001\u2162\uff08\u53f3\uff09\u7ec8\u6b62\u5f00\u53d1\u7684\u539f\u56e0<\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><br  \/><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress3-1533785919-1.jpg\" alt=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\" title=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\"  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\">\u56fe3. \u65b0\u836f\u7814\u53d1\u5931\u8d25\u539f\u56e0(1991\u20132000).&nbsp;<\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><br  \/><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress0-1533785919.jpg\" alt=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\" title=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\"  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\">\u56fe4. 2008\u20132010\u4e34\u5e8aII \u671f\u5931\u8d25 (a) \u5931\u8d25\u539f\u56e0\uff08b\uff09\u6cbb\u7597\u9886\u57df<\/p>\n<p style=\"line-height:150%;\"><strong><span style=\"font-size:16px;line-height:150%;color:#231F20;\"><br  \/><\/span><\/strong><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong><span style=\"color: rgb(217, 33, 66);\">DMPK\u4e34\u5e8a\u524d\u7814\u7a76\u76ee\u7684<\/span><\/strong><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">&nbsp;<\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u4e3a\u4e86\u53d6\u5f97\u5546\u4e1a\u4e0a\u7684\u6210\u529f\u6216\u8005\u5177\u6709\u4e34\u5e8a\u5e94\u7528\u4f18\u52bf\uff0c\u4e00\u4e2a\u7406\u60f3\u7684\u836f\u7269\u9700\u6709\u5408\u9002\u7684\u7ed9\u836f\u5242\u91cf\u548c\u7ed9\u836f\u65b9\u6848\uff0c\u4e0e\u5176\u4ed6\u836f\u7269\u5408\u7528\u4e0d\u9700\u8981\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002\u4ee5\u53e3\u670d\u836f\u7269\u4e3a\u4f8b\uff0c\u5219\u662f\u8981\u6c42\u5316\u5408\u7269\u9ad8\u6eb6\u9ad8\u6e17\uff0c\u751f\u7269\u5229\u7528\u5ea6\u9ad8\uff0c\u6709\u5408\u9002\u7684\u534a\u8870\u671f\uff0c\u6ca1\u6709\u836f\u7269-\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3002\u4e3a\u4e86\u5f97\u5230\u8fd9\u6837\u7684\u5019\u9009\u5316\u5408\u7269\uff0c\u5728\u65b0\u836f\u7b5b\u9009\u548c\u4f18\u5316\u9636\u6bb5\u5c31\u9700\u8981\u91c7\u7528\u5408\u9002\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u548c\u8bc4\u4ef7\u7b56\u7565\uff0c\u5e76\u8fbe\u5230\u4e24\u4e2a\u76ee\u7684\uff1a1\uff09\u5efa\u7acb\u5b9a\u91cf\u7ed3\u6784-\u6027\u8d28\u76f8\u5173\u6027\uff08QSPR\uff09\uff0c\u5e2e\u52a9\u5316\u5408\u7269\u7ed3\u6784\u8bbe\u8ba1\u4ee5\u4f18\u5316DMPK\u6027\u8d28\u30022\uff09\u5efa\u7acb\u4f53\u5185-\u4f53\u5916\u76f8\u5173\u6027\uff0c\u4ee5\u901a\u8fc7\u4f53\u5916\u6570\u636e\u5e76\u7ed3\u5408\u836f\u6027\u548c\u5b89\u5168\u6027\u9884\u6d4b\u4e34\u5e8a\u60c5\u51b5\u3002\u4e0b\u9762\u5c31\u91cd\u70b9\u4ecb\u7ecd\u4e00\u4e0b\u5de5\u4e1a\u754c\u5e38\u7528\u7684DMPK\u7b5b\u9009\u548c\u8bc4\u4ef7\u5b9e\u9a8c\u6a21\u578b\u3002<\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">&nbsp;<\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"color: rgb(217, 33, 66);\"><strong>DMPK\u9ad8\u901a\u91cf\u7b5b\u9009\u65b9\u6cd5<\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"color: rgb(217, 33, 66);\"><strong>\u4f53\u5916\u4ee3\u8c22\u7a33\u5b9a\u6027\u7814\u7a76<\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u8bb8\u591a\u5728\u4f53\u5916\u663e\u793a\u9ad8\u6d3b\u6027\u7684\u5316\u5408\u7269\u7531\u4e8e\u5176\u4e0d\u826f\u7684\u4ee3\u8c22\u7279\u6027\uff0c\u800c\u5728\u4f53\u5185\u65e0\u6548\u6216\u7531\u4e8e\u53cd\u5e94\u6027\u4ee3\u8c22\u7269\u4ea7\u751f\u6bd2\u6027\u800c\u5931\u53bb\u5f00\u53d1\u4ef7\u503c\u3002\u56e0\u6b64\uff0c\u5408\u7406\u7684\u836f\u7269\u8bbe\u8ba1\u5e94\u8003\u8651\u5230\u836f\u7269\u4ee3\u8c22\u9014\u5f84\u53ca\u76f8\u5173\u7684\u836f\u7269\u4ee3\u8c22\u9176\uff0c\u53d1\u73b0\u5148\u5bfc\u5316\u5408\u7269\u7684\u4ee3\u8c22\u5f31\u70b9\uff0c\u5bf9\u5176\u7ed3\u6784\u8fdb\u884c\u6539\u9020\uff0c\u4ee5\u589e\u52a0\u4ee3\u8c22\u7a33\u5b9a\u6027\u6216\u964d\u4f4e\u6bd2\u6027\u3002\u5728\u65b0\u836f\u53d1\u5f00\u9636\u6bb5\u53ef\u4ee5\u5148\u7528\u5404\u79cd\u4f53\u5916\u6a21\u578b\u5bf9\u5316\u5408\u7269\u7684\u4ee3\u8c22\u7279\u6027\u8fdb\u884c\u7b5b\u9009\uff0c\u4ee5\u786e\u5b9a\u5176\u662f\u5426\u6709\u7ee7\u7eed\u5f00\u53d1\u7684\u4ef7\u503c\u3002\u5e38\u7528\u7684\u4f53\u5916\u4ee3\u8c22\u7814\u7a76\u6a21\u578b\u4e3b\u8981\u6709\u809d\u5fae\u7c92\u4f53\u3001S9\u3001\u809d\u7ec6\u80de\u3001\u809d\u7ec4\u7ec7\u5300\u6d46\u3001\u5404\u79cd\u91cd\u7ec4\u9176\u3001\u8840\u6d46\u3001\u5168\u8840\u7b49\u3002\u836f\u7269\u7684\u4ee3\u8c22\u53cd\u5e94\u4e3b\u8981\u5305\u62ec\u6c27\u5316\u3001\u8fd8\u539f\u3001\u6c34\u89e3\u53ca\u7ed3\u5408\u7b49\uff0c\u53c2\u4e0e\u751f\u7269\u8f6c\u5316\u7684\u4e3b\u8981\u4ee3\u8c22\u9176\u5206\u522b\u89c1\u88681\u548c\u88682\u3002\u5728\u5316\u5408\u7269\u7b5b\u9009\u9636\u6bb5\uff0c\u53ef\u6839\u636e\u5316\u5408\u7269\u7684\u7ed3\u6784\u7279\u70b9\u53ca\u53ef\u80fd\u7684\u4ee3\u8c22\u9014\u5f84\u9009\u62e9\u4e00\u79cd\u6216\u4e24\u79cd\u4ee3\u8c22\u4f53\u7cfb\u8fdb\u884c\u7a33\u5b9a\u6027\u8bc4\u4ef7\u3002\u7531\u4e8eCYP450\u9176\u53c2\u4e0e\u4e86\u8fd170%\u836f\u7269\u7684\u4ee3\u8c22\uff0c\u800cCYP450\u4e3b\u8981\u5206\u5e03\u4e8e\u809d\u5fae\u7c92\u4f53\u4e0a\uff0c\u4e14\u809d\u5fae\u7c92\u4f53\u76f8\u8f83\u4e8eS9\u548c\u809d\u7ec6\u80de\u53c8\u6bd4\u8f83\u7ecf\u6d4e\u5e76\u6613\u4e8e\u50a8\u5b58\uff0c\u6545\u6700\u5e38\u7528\u809d\u5fae\u7c92\u4f53+NADPH\u4f53\u7cfb\u7b5b\u9009\u5316\u5408\u7269\u3002\u5f53\u5316\u5408\u7269\u7ed3\u6784\u5f0f\u5224\u65ad\uff0c\u6240\u7814\u7a76\u9879\u76ee\u7684\u5316\u5408\u7269\u4e3b\u8981\u7ecf\u975e\u5fae\u7c92\u4f53\u9176\u4ee3\u8c22\u65f6\u5219\u9700\u91c7\u7528\u5176\u4ed6\u4f53\u5916\u5b9e\u9a8c\u4f53\u7cfb\u3002\u8b6c\u5982\u5316\u5408\u7269\u542b\u7fa7\u57fa\uff0c\u5219\u5316\u5408\u7269\u53ef\u80fd\u53d1\u751f\u8461\u8404\u7cd6\u919b\u9178\u7ed3\u5408\u53cd\u5e94\uff0c\u800c\u524d\u671f\u809d\u5fae\u7c92\u4f53\u548c\u809d\u7ec6\u80de\u7a33\u5b9a\u6027\u7684\u7ed3\u679c\u8868\u660e\u8be5\u7cfb\u5217\u5316\u5408\u7269\u786e\u5b9e\u4e3b\u8981\u53d1\u751f\u8461\u8404\u7cd6\u919b\u9178\u5316\u4ee3\u8c22\uff0c\u5219\u53ef\u4ee5\u9009\u7528\u809d\u5fae\u7c92+ NADPH+UDPGA\u4f53\u7cfb\u6216\u809d\u7ec6\u80de\u4f53\u7cfb\u8fdb\u884c\u9ad8\u901a\u91cf\u7b5b\u9009\u3002\u53c8\u5982\u7b5b\u9009\u7684\u5316\u5408\u7269\u662f\u524d\u836f\uff0c\u4e3b\u8981\u7ecf\u916f\u9176\u4ee3\u8c22\u4e3a\u539f\u836f\uff0c\u7ecf\u786e\u8ba4\u5316\u5408\u7269\u5728PBS\u4e2d\u7a33\u5b9a\u540e\uff0c\u5219\u9700\u8981\u8003\u5bdf\u5316\u5408\u7269\u5728\u8840\u6d46\u548c\u809d\u5fae\u7c92\u4f53\u4e2d\u7684\u7a33\u5b9a\u6027\uff0c\u5e76\u6d4b\u5b9a\u539f\u836f\u7684\u751f\u6210\u7387\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u5316\u5408\u7269\u7b5b\u9009\u9636\u6bb5\uff0c\u8fdb\u884c\u4ee3\u8c22\u7a33\u5b9a\u6027\u7814\u7a76\u7684\u76ee\u7684\u5c31\u662f1. \u8003\u5bdf\u5316\u5408\u7269\u4ee3\u8c22\u7a33\u5b9a\u6027\uff0c\u5c06\u4e0d\u7a33\u5b9a\u7684\u5316\u5408\u7269\u7b5b\u6389\uff1b2. \u786e\u5b9a\u79cd\u5c5e\u5dee\u5f02\uff0c\u836f\u6548\u6a21\u578b\u79cd\u5c5e\uff08\u5982\u5927\u9f20\uff09\u548c\u4eba\u4ee3\u8c22\u5747\u6bd4\u8f83\u7a33\u5b9a\u7684\u53ef\u8003\u8651\u7ee7\u7eed\u5f00\u53d1\u3002\u5982\u679c\u5316\u5408\u7269\u5728\u4eba\u809d\u5fae\u7c92\u4f53\u4e2d\u7a33\u5b9a\uff0c\u5728\u5927\u9f20\u809d\u5fae\u7c92\u4f53\u4e2d\u5f88\u4e0d\u7a33\u5b9a\uff0c\u90a3\u4e48\u8be5\u5316\u5408\u7269\u7684\u6709\u6548\u6027\u53ef\u80fd\u56e0\u4e3a\u5728\u5927\u9f20\u4e2d\u66b4\u9732\u91cf\u4e0d\u8db3\u800c\u5f97\u4e0d\u5230\u9a8c\u8bc1\uff0c\u7ee7\u7eed\u5f00\u53d1\u5b58\u5728\u98ce\u9669\uff1b\u5982\u679c\u5316\u5408\u7269\u5728\u5927\u9f20\u809d\u5fae\u7c92\u4f53\u4e2d\u7a33\u5b9a\uff0c\u4f46\u5728\u4eba\u809d\u5fae\u7c92\u4f53\u4e2d\u5f88\u4e0d\u7a33\u5b9a\uff0c\u90a3\u4e48\u8fd9\u79cd\u5316\u5408\u7269\u5f88\u53ef\u80fd\u5728\u5927\u9f20\u75be\u75c5\u6a21\u578b\u4e2d\u5c55\u793a\u8f83\u597d\u7684\u836f\u6548\uff0c\u7ee7\u7eed\u5f00\u53d1\u5728\u4e34\u5e8a\u4e0a\u53ef\u80fd\u56e0\u4e3a\u4eba\u4f53\u66b4\u9732\u91cf\u4e0d\u8db3\u800c\u5bfc\u81f4\u836f\u6548\u4e0d\u8db3\u30023. \u5224\u65ad\u4ee3\u8c22\u8f6f\u4f4d\u70b9\uff0c\u5bf9\u5176\u8fdb\u884c\u7ed3\u6784\u6539\u9020\uff1b4. \u5efa\u7acb\u4f53\u5916\u6e05\u9664\u7387\u548c\u4f53\u5185\u6e05\u9664\u7387\u7684\u76f8\u5173\u6027\uff0c\u786e\u5b9a\u76f8\u5173\u6027\u826f\u597d\u5219\u53ef\u7528\u4f53\u5916\u4ee3\u8c22\u6a21\u578b\u8fdb\u884c\u5927\u91cf\u5316\u5408\u7269\u7684\u7b5b\u9009\uff0c\u53ef\u52a0\u5feb\u7b5b\u9009\u901f\u5ea6\u5e76\u53ef\u51cf\u5c11\u52a8\u7269PK\u5b9e\u9a8c\u800c\u8282\u7ea6\u8d39\u7528\u3002<\/p>\n<p style=\"line-height:150%;\"><span style=\"font-size:16px;line-height:150%;font-family:\u5b8b\u4f53;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 150%;text-align: center;\"><span style=\"font-size:16px;line-height:150%;font-family:\u5b8b\u4f53;color:#231F20;\">\u8868<\/span><span style=\"font-size:16px;line-height:150%;color:#231F20;\">1. <\/span><span style=\"font-size:16px;line-height:150%;font-family:\u5b8b\u4f53;color:#231F20;\">\u836f\u7269\u7684\u6c27\u5316\u3001\u8fd8\u539f\u548c\u6c34\u89e3\u9176<\/span><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533785919.png\" alt=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\" title=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\"  \/><\/p>\n<p style=\"line-height: 150%;text-align: center;\"><span style=\"font-size:16px;line-height:150%;font-family:\u5b8b\u4f53;color:#231F20;\">\u8868<\/span><span style=\"font-size:16px;line-height:150%;color:#231F20;\">2. <\/span><span style=\"font-size:16px;line-height:150%;font-family:\u5b8b\u4f53;color:#231F20;\">\u836f\u7269\u7684\u7ed3\u5408\u4ee3\u8c22\u9176<\/span><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533785920.png\" alt=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\" title=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(217, 33, 66);\"><strong>\u5c0f\u80a0\u7684\u5438\u6536\u8bc4\u4ef7<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\">\u76ee\u524d\u5e38\u7528\u4e8e\u8bc4\u4ef7\u836f\u7269\u7684\u6e17\u900f\u6027\u548c\u5c0f\u80a0\u5438\u6536\u7684\u6709Caco-2\u7ec6\u80de\u7cfb\u548cPAMPA\u4eba\u5de5\u819c\u3002\u5176\u4e2dPAMPA\u662f\u57fa\u4e8e\u88ab\u52a8\u6269\u6563\u65b9\u5f0f\u7684\u5438\u6536\u8bc4\u4ef7\u6a21\u578b\uff0c\u6210\u672c\u4f4e\u3001\u901a\u91cf\u9ad8\u3002Caco-2\u7ec6\u80de\u682a\u662f\u7814\u7a76\u836f\u7269\u5c0f\u80a0\u5438\u6536\u6700\u5e38\u7528\u7684\u4e0a\u76ae\u7ec6\u80de\u682a\uff0c\u6765\u6e90\u4e8e\u4eba\u7c7b\u7ed3\u80a0\u817a\u764c\u7ec6\u80de\uff0c\u5177\u6709\u548c\u5c0f\u80a0\u4e0a\u76ae\u76f8\u4f3c\u7684\u5f62\u6001\u548c\u529f\u80fd\uff0c\u5728\u6807\u51c6\u57f9\u517b\u6761\u4ef6\u4e0b\u7ec6\u80de\u80fd\u81ea\u52a8\u5206\u5316\uff0c\u7d27\u5bc6\u8fde\u63a5\uff0c\u8868\u8fbe\u591a\u79cd\u5237\u72b6\u7f18\u9176\u3001\u4e00\u4e9bP450\u540c\u5de5\u9176\u53ca\u51e0\u79cdII\u76f8\u4ee3\u8c22\u9176\uff0c\u8fd8\u8868\u8fbe\u591a\u79cd\u8f6c\u8fd0\u4f53\u7edf\uff0c\u5982\u7cd6\u7c7b\u3001\u6c28\u57fa\u9178\u3001\u4e8c\u80bd\u3001\u80c6\u9178\u53ca\u7ef4\u751f\u7d20B12\u7b49\u5185\u6e90\u6027\u56e0\u5b50\u7684\u4e3b\u52a8\u8f6c\u8fd0\u4f53\u3002\u6b64\u5916\uff0cCaco-2\u8fd8\u8868\u8fbe\u5c0f\u80a0\u4e0a\u5b58\u5728\u7684\u591a\u79cd\u836f\u7269\u5916\u6392\u86cb\u767d\u5982P-\u7cd6\u86cb\u767d\u3001BCRP\u3001MRP1\u7b49\u3002Caco-2\u7ec6\u80de\u682a\u7684\u5206\u5316\u7a0b\u5ea6\u6781\u9ad8\uff0c\u57f9\u517b\u5728\u652f\u6301\u7269\u4e0a\uff0c\u6b63\u5e38\u57f9\u517b21\u5929\u5373\u53ef\u5b8c\u6210\u81ea\u52a8\u5206\u5316\uff0c\u5206\u5316\u540e\u5f62\u6210\u5177\u6709\u5fae\u7ed2\u6bdb\u4ee5\u53ca\u7d27\u5bc6\u8fde\u63a5\u7b49\u7c7b\u4f3c\u4e8e\u5c0f\u80a0\u4e0a\u76ae\u7ec6\u80de\u5237\u72b6\u7f18\u6d4b\u7684\u5206\u5316\u7279\u5f81\u7684\u5355\u7ec6\u80de\u5c42[8]\u3002\u56e0\u6b64\uff0cCaco-2\u7ec6\u80de\u682a\u53ef\u7528\u4e8e\u7814\u7a76\u836f\u7269\u7ed3\u6784-\u53e3\u670d\u5438\u6536\u5206\u6570\u7684\u5173\u7cfb\u3001\u9884\u6d4b\u5316\u5408\u7269\u4f53\u5185\u5438\u6536\u7a0b\u5ea6\u3001\u7814\u7a76\u5438\u6536\u7684\u673a\u5236\u3001P-\u7cd6\u86cb\u767d\u5e95\u7269\u7684\u7b5b\u9009\u7b49\u3002\u5c3d\u7ba1Caco-2\u7ec6\u80de\u80fd\u8f83\u597d\u5730\u6a21\u62df\u836f\u7269\u7684\u5c0f\u80a0\u5438\u6536\u548c\u8f6c\u8fd0\uff0c\u4f46\u4e5f\u6709\u4e00\u5b9a\u7684\u7f3a\u9677\uff1a\u2474\u7f3a\u5c11\u80a0\u58c1\u7684\u9ecf\u6db2\u5c42\uff1b\u2475\u8f6c\u8fd0\u86cb\u767d\u8868\u8fbe\u6c34\u5e73\u4e0e\u6b63\u5e38\u5c0f\u80a0\u4e0d\u4e00\u81f4\uff1b\u2476\u4ee3\u8c22\u9176\u8868\u8fbe\u91cf\u4e0e\u6b63\u5e38\u7ec6\u80de\u6709\u5dee\u522b\uff1b\u2477\u8fc7\u7d27\u7684\u7d27\u5bc6\u8fde\u63a5\u3002\u8fd9\u4e9b\u56e0\u7d20\u4f7f\u5f97\u5bf9\u4e8e\u67d0\u4e9b\u836f\u7269\u800c\u8a00\uff0c\u91c7\u7528Caco-2\u7ec6\u80de\u6240\u5f97\u5230\u7684\u6570\u636e\u4e0e\u5176\u53e3\u670d\u540e\u5728\u4f53\u5185\u5438\u6536\u7684\u76f8\u5173\u6027\u4e0d\u7406\u60f3\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u4e0d\u540c\u5b9e\u9a8c\u5ba4\u7684Caco-2\u7ec6\u80de\u6765\u6e90\u548c\u57f9\u517b\u65b9\u6cd5\u4e0d\u540c\uff0c\u4ee5\u81f3\u4e8e\u6240\u5f97\u51fa\u7ed3\u8bba\u53ef\u6bd4\u5ea6\u8f83\u4f4e\u3002\u5373\u4f7f\u662f\u540c\u4e00\u4e2a\u5b9e\u9a8c\u5ba4\u7684\u7ec6\u80de\uff0c\u4e5f\u4f1a\u56e0\u7ec6\u80de\u4f20\u4ee3\u6b21\u6570\u3001\u57f9\u517b\u65f6\u95f4\u3001\u57f9\u517b\u4ecb\u8d28\u7684\u4e0d\u540c\u800c\u53d8\u5316\u3002\u56e0\u6b64\uff0c\u5b9e\u9a8c\u91c7\u7528\u5728\u4e00\u5b9a\u4ee3\u6570\u8303\u56f4\u5185\u7684\u7ec6\u80de\u53ca\u89c4\u8303\u7684\u7ec6\u80de\u57f9\u517b\u65b9\u6cd5\uff0c\u5bf9\u4e8e\u83b7\u5f97\u6570\u636e\u7684\u91cd\u73b0\u6027\u662f\u975e\u5e38\u91cd\u8981\u7684\uff0c\u5e76\u4e14\u9700\u8981\u4f7f\u7528\u4e8c\u4e09\u5341\u79cd\u4f4e\u3001\u4e2d\u3001\u9ad8\u4e0d\u540c\u6e17\u900f\u6027\u7684\u6a21\u578b\u836f\u7269\u5efa\u7acb\u8868\u89c2\u6e17\u900f\u7cfb\u6570Papp\u4e0e\u5438\u6536\u7a0b\u5ea6\u7684\u76f8\u5173\u6027\uff0c\u7136\u540e\u624d\u53ef\u7528\u4e8e\u6d4b\u5b9a\u672a\u77e5\u5316\u5408\u7269\u7684\u6e17\u900f\u6027\u3002<\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"color: rgb(217, 33, 66);\"><strong>CYP450\u9176\u6291\u5236\u7814\u7a76<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\">\u56e0\u836f\u7269-\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u800c\u5bfc\u81f4\u7684\u9000\u5e02\u7684\u4f8b\u5b50\u6709\u597d\u51e0\u4e2a\uff08\u88683\uff09\uff0c\u4e3b\u8981\u662f\u56e0\u4e3aCYP450\u6291\u5236\u800c\u4ea7\u751f\u5b89\u5168\u6027\u95ee\u9898\u3002\u5728\u4e34\u5e8a\u5f00\u53d1\u4e2d\uff0c\u5982\u679c\u836f\u7269\u53ef\u80fd\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\u7684\u98ce\u9669\u8f83\u5927\uff0c\u4e5f\u9700\u8981\u8fdb\u4e00\u6b65\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u8bc4\u4ef7\u836f\u7269\u7684\u76f8\u4e92\u4f5c\u7528\u4ee5\u786e\u5b9a\u4e34\u5e8a\u5e94\u7528\u662f\u5426\u9700\u8981\u8fdb\u884c\u5242\u91cf\u8c03\u6574[9]\uff0c\u8fd9\u4f1a\u589e\u52a0\u4e34\u5e8a\u6210\u672c\uff0c\u4e5f\u53ef\u80fd\u5bfc\u81f4\u836f\u7269\u4e0a\u5e02\u540e\u7528\u836f\u4e0d\u4fbf\u6216\u4f7f\u7528\u53d7\u9650\u3002\u56e0\u6b64\uff0c\u5728\u65b0\u836f\u7b5b\u9009\u548c\u5f00\u53d1\u9636\u6bb5\u8bc4\u4ef7\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u53ef\u80fd\u6027\u662f\u975e\u5e38\u5fc5\u8981\u7684\uff0c\u5c24\u5176\u662f\u4e34\u5e8a\u4e0a\u5f88\u53ef\u80fd\u9700\u5408\u5e76\u7528\u836f\u7684\uff0c\u5982\u964d\u7cd6\u836f\u3001\u964d\u8102\u836f\u3001\u964d\u538b\u836f\u7b49\uff0c\u66f4\u5e94\u5c3d\u53ef\u80fd\u907f\u514d\u4ea7\u751f\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3002\u7531\u4e8e70%\u7684\u4ee3\u8c22\u6027\u76f8\u4e92\u4f5c\u7528\u662f\u7531\u9176\u6291\u5236\u5bfc\u81f4\u7684\uff0c\u5728\u5316\u5408\u7269\u7b5b\u9009\u9636\u6bb5\u4e3b\u8981\u8003\u5bdf\u5316\u5408\u7269\u5bf9CYP450\u9176\u7684\u6291\u5236\u80fd\u529b\u3002\u5176\u4e2dCYP1A2\u30012C9\u30012C19\u30012D6\u548c3A4\/5\u53c2\u4e0e\u4e8660%\u4ee5\u4e0a\u7684\u836f\u7269\u4ee3\u8c22\uff0c\u6545\u9ad8\u901a\u91cf\u7b5b\u9009\u65f6\u4e3b\u8981\u8bc4\u4ef7\u5316\u5408\u7269\u5bf9CYP1A2\u30012C9\u30012C19\u30012D6\u548c3A4\/5\u7684\u6291\u5236\u4f5c\u7528\u3002\u5e38\u7528CYP\u6291\u5236\u5b9e\u9a8c\u65b9\u6cd5\u89c1\u88684\u3002<\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: center;\"><span style=\"font-size:16px;font-family:\u5b8b\u4f53;\">\u8868<\/span><span style=\"font-size:16px;\">3. <\/span><span style=\"font-size:16px;font-family:\u5b8b\u4f53;\">\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u5bfc\u81f4\u9000\u5e02\u7684\u836f\u7269<\/span><\/p>\n<p><img class=\"\"         style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress1-1533785920.jpg\" alt=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\" title=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;\">\u8868<\/span><span style=\"font-size: 16px;\">4 CYP<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;\">\u6291\u5236\u8bd5\u9a8c\u65b9\u6cd5<\/span><\/p>\n<p><img class=\"\"      style=\"width: 100%;height: auto;\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533785920-1.png\" alt=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\" title=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size:16px;font-family:\u5b8b\u4f53;\"><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"color: rgb(217, 33, 66);\"><strong>\u8840\u6d46\u86cb\u767d\u7ed3\u5408\u7387\u6d4b\u5b9a<\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u836f\u7269\u8fdb\u5165\u8840\u6db2\u540e\uff0c\u4f1a\u4e0e\u591a\u79cd\u8840\u6db2\u6210\u5206\u7ed3\u5408\uff0c\u5982\u7ea2\u7ec6\u80de\u3001\u767d\u7ec6\u80de\u3001\u8840\u5c0f\u677f\u4ee5\u53ca\u8840\u6d46\u86cb\u767d\u3002\u53ea\u6709\u6e38\u79bb\u578b\u7684\u836f\u7269\u624d\u80fd\u900f\u8fc7\u751f\u7269\u819c\u8fdb\u5165\u5230\u7ec4\u7ec7\u6216\u9776\u5668\u5b98\uff0c\u4ea7\u751f\u6548\u5e94\u6216\u8fdb\u884c\u4ee3\u8c22\u548c\u6392\u6cc4\uff0c\u800c\u7ed3\u5408\u578b\u7684\u836f\u7269\u5219\u8d77\u7740\u7c7b\u4f3c\u50a8\u5e93\u7684\u4f5c\u7528\u3002\u7531\u4e8e\u836f\u7269\u5728\u9776\u7ec4\u7ec7\u7684\u6e38\u79bb\u6d53\u5ea6\u51b3\u5b9a\u836f\u6548\uff0c\u4e14\u8840\u6d46\u86cb\u767d\u7ed3\u5408\u5bf9\u836f\u7269\u5728\u4f53\u5185\u7684\u5206\u5e03\u548c\u6e05\u9664\u90fd\u6709\u5f71\u54cd\uff0c\u56e0\u6b64\u5728\u5316\u5408\u7269\u7b5b\u9009\u9636\u6bb5\u9700\u8981\u6d4b\u5b9a\u8840\u6d46\u86cb\u767d\u7ed3\u5408\u7387\u3002\u5e7f\u6cdb\u5e94\u7528\u7684\u4f53\u5916\u8840\u6d46\u86cb\u767d\u7ed3\u5408\u7387\u6d4b\u5b9a\u65b9\u6cd5\u6709\u5e73\u8861\u900f\u6790\u6cd5\u3001\u8d85\u6ee4\u6cd5\u548c\u8d85\u901f\u79bb\u5fc3\u6cd5\uff0c\u5176\u4e2d\u5e73\u8861\u900f\u6790\u6cd5\u88ab\u8ba4\u4e3a\u662f\u201c\u91d1\u6807\u51c6\u201d\u3002\u4e09\u79cd\u65b9\u6cd5\u5206\u522b\u6709\u5404\u81ea\u7684\u4f18\u7f3a\u70b9\uff0c\u8be6\u89c1\u88685\u3002\u5bf9\u4e8e\u975e\u7279\u5f02\u6027\u5438\u9644\u8f83\u5927\u7684\u5316\u5408\u7269\uff0c\u9996\u9009\u8d85\u901f\u79bb\u5fc3\u6cd5\uff1b\u5bf9\u4e8e\u5728\u8840\u6d46\u4e2d\u4e0d\u592a\u7a33\u5b9a\u7684\u5316\u5408\u7269\uff0c\u9996\u9009\u8d85\u6ee4\u6cd5\uff1b\u5bf9\u4e8e\u5728\u8840\u6d46\u4e2d\u4e0d\u7a33\u5b9a\u800c\u4e14\u8fd8\u5b58\u5728\u975e\u7279\u6027\u5438\u9644\u7684\u5316\u5408\u7269\uff0c\u76ee\u524d\u6ca1\u6709\u7279\u522b\u6709\u6548\u7684\u65b9\u6cd5\u53ef\u4ee5\u51c6\u786e\u6d4b\u5b9a\u8840\u6d46\u86cb\u767d\u7ed3\u5408\u7387\u3002<\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 150%;text-align: center;\"><span style=\"font-size:16px;line-height:150%;font-family:\u5b8b\u4f53;color:#231F20;\">\u8868<\/span><span style=\"font-size:16px;line-height:150%;color:#231F20;\">5. <\/span><span style=\"font-size:16px;line-height:150%;font-family:\u5b8b\u4f53;color:#231F20;\">\u6d4b\u5b9a\u8840\u6d46\u86cb\u767d\u7ed3\u5408\u7387\u65b9\u6cd5\u7684\u6bd4\u8f83<\/span><\/p>\n<p><img class=\"\"      style=\"width: 100%;height: auto;\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress4-1533785920.png\" alt=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\" title=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"color: rgb(217, 33, 66);\"><strong>\u4f53\u5185PK\u7b5b\u9009\u65b9\u6cd5<\/strong><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u4f53\u5916\u7b5b\u9009\u6a21\u578b\u5177\u6709\u901f\u5ea6\u5feb\u3001\u6210\u672c\u4f4e\u7684\u7279\u70b9\uff0c\u4f46\u662f\u5b9e\u9a8c\u7ed3\u679c\u4e0e\u4f53\u5185\u771f\u5b9e\u60c5\u51b5\u5b58\u5728\u76f8\u5173\u6027\u7684\u95ee\u9898\uff0c\u5e76\u4e14\u6ca1\u6709\u52a8\u7269\u4f53\u5185\u5b9e\u9a8c\u7ed3\u679c\uff0c\u5728\u6574\u4e2a\u673a\u4f53\u6c34\u5e73\u4e86\u89e3\u836f\u7269\u5728\u4f53\u5185\u7684\u5438\u6536\u3001\u5206\u5e03\u3001\u4ee3\u8c22\u548c\u6392\u6cc4\u662f\u4e0d\u591f\u7684\uff0c\u56e0\u6b64\u5f00\u5c55\u4f53\u5185PK\u7814\u7a76\u4e5f\u662f\u5341\u5206\u5fc5\u8981\u7684\u3002\u4e0e\u4f53\u5916\u5b9e\u9a8c\u76f8\u6bd4\uff0c\u4f53\u5185\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u9700\u8981\u8f83\u957f\u7684\u65f6\u95f4\u548c\u8f83\u5927\u5f3a\u5ea6\u7684\u5de5\u4f5c\u91cf\uff0c\u5176\u901a\u91cf\u5f80\u5f80\u6bd4\u8f83\u4f4e\u3002<\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u76ee\u524d\uff0c\u52a0\u5feb\u836f\u7269\u4f53\u5185PK\u7b5b\u9009\u901f\u5ea6\u4e3b\u8981\u4ece\u4e24\u4e2a\u65b9\u9762\u7740\u624b\u3002\u9996\u5148\u662f\u7f29\u77ed\u5f53\u4e2a\u751f\u7269\u6837\u54c1\u5b9a\u91cf\u5206\u6790\u7684\u65f6\u95f4\uff0c\u63d0\u9ad8\u5206\u6790\u901a\u91cf\uff1b\u5176\u6b21\u662f\u9488\u5bf9\u73b0\u6709\u52a8\u7269\u5b9e\u9a8c\u65b9\u6848\u8fdb\u884c\u5408\u7406\u7b80\u5316\uff0c\u5728\u80fd\u591f\u5f97\u5230\u6709\u6548\u4fe1\u606f\u7684\u60c5\u51b5\u4e0b\uff0c\u5efa\u7acb\u9002\u7528\u4e8e\u7b5b\u9009\u7684\u52a8\u7269\u5b9e\u9a8c\u6a21\u578b\uff0c\u51cf\u5c11\u9700\u8981\u5206\u6790\u7684\u751f\u7269\u6837\u54c1\u6570\u91cf\u3002\u76ee\u524d\u5e7f\u6cdb\u4f7f\u7528\u7684UPLC-MS\/MS\u6280\u672f\uff0c\u901a\u5e38\u5206\u6790\u4e00\u4e2a\u751f\u7269\u6837\u54c1\u7684\u65f6\u95f4\u4e3a2~4\u5206\u949f\uff0c\u5206\u6790\u901f\u5ea6\u5df2\u7ecf\u633a\u5feb\u4e86\u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u63d0\u9ad8\u901a\u91cf\uff0c\u76ee\u524d\u5e38\u7528\u76d2\u5f0f\u7ed9\u836f\uff08Cassette dosing\uff09\u65b9\u6848\uff0c\u5373\u5c06n\u4e2a\u836f\u7269\u914d\u7f6e\u6210\u6df7\u5408\u7684\u7ed9\u836f\u6eb6\u6db2\u518d\u7ed9\u4e88\u52a8\u7269\u3002\u8fd9\u8be5\u65b9\u6848\u7684\u4f18\u52bf\u662f\uff1a\u5927\u5927\u51cf\u5c11\u5b9e\u9a8c\u52a8\u7269\u7684\u7528\u91cf\u548c\u751f\u7269\u6837\u54c1\u7684\u6570\u91cf\uff0c\u540c\u65f6\u51cf\u8f7b\u4e86\u52a8\u7269\u6280\u672f\u5458\u548c\u751f\u7269\u6837\u54c1\u5206\u6790\u5458\u7684\u5de5\u4f5c\u91cf\uff0c\u6b64\u5916\uff0c\u5728\u540c\u4e00\u53ea\u52a8\u7269\u8eab\u4e0a\u5f97\u5230\u4e0d\u540c\u5316\u5408\u7269\u7684PK\u6027\u8d28\uff0c\u4fbf\u4e8e\u6bd4\u8f83\u4e0d\u540c\u5316\u5408\u7269\u7684PK\u5dee\u5f02\u3002\u8fd9\u4e2a\u65b9\u6848\u7684\u7f3a\u70b9\u662f\uff1a\u9700\u8981\u627e\u5230\u5408\u9002\u7684\u6eb6\u5a92\uff0c\u4fdd\u8bc1\u8fd9\u4e9b\u5316\u5408\u7269\u80fd\u591f\u540c\u65f6\u7ed9\u836f\uff1b\u5176\u6b21\u662f\u8981\u5efa\u7acb\u591a\u4e2a\u5316\u5408\u7269\u540c\u65f6\u68c0\u6d4b\u7684\u5206\u6790\u65b9\u6cd5\uff0c\u52a0\u5927\u4e86\u5206\u6790\u65b9\u6cd5\u5f00\u53d1\u548c\u5efa\u7acb\u7684\u96be\u5ea6\uff1b\u6b64\u5916\uff0c\u836f\u7269-\u836f\u7269\u4e4b\u95f4\u53ef\u80fd\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u5f71\u54cd\u5b9e\u9a8c\u7ed3\u679c\u7684\u51c6\u786e\u6027\uff0c\u56e0\u6b64\u8981\u964d\u4f4e\u6bcf\u4e2a\u5316\u5408\u7269\u7684\u7ed9\u836f\u5242\u91cf\uff0c\u5e76\u4e14\u5f15\u5165\u5df2\u77e5PK\u6027\u8d28\u7684\u57fa\u51c6\u5316\u5408\u7269\u4f5c\u4e3a\u9633\u6027\u5bf9\u7167\u3002\u5728\u5b9e\u9645\u5de5\u4f5c\u4e2d\uff0c\u4e00\u822c\u662f\u5c063~5\u4e2a\u5316\u5408\u7269\u4f4e\u5242\u91cf\u6df7\u5408\u7ed9\u836f\uff0c\u4e3a\u4e86\u964d\u4f4e\u5206\u6790\u65b9\u6cd5\u5f00\u53d1\u7684\u96be\u5ea6\uff0c\u5404\u4e2a\u5316\u5408\u7269\u4e4b\u95f4\u5e73\u5747\u5206\u5b50\u91cf\u76f8\u5dee4 Da\u4ee5\u4e0a\u3002<\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u4ee5\u4e0a\u4ecb\u7ecd\u7684\u90fd\u662f\u5de5\u4e1a\u754c\u5728\u65b0\u836f\u5c0f\u5206\u5b50\u7b5b\u9009\u65f6\u5e7f\u6cdb\u8fd0\u7528\u7684\u4e00\u4e9b\u5b9e\u9a8c\u65b9\u6cd5\uff0c\u6839\u636e\u4e0d\u540c\u9879\u76ee\u7684\u7279\u70b9\uff0c\u90e8\u5206\u9879\u76ee\u5728\u524d\u671f\u7b5b\u9009\u65f6\u8fd8\u9700\u8fdb\u884c\u8f6c\u8fd0\u4f53\u7814\u7a76\u3001\u9176\u8bf1\u5bfc\u7814\u7a76\u3001\u4ee3\u8c22\u8868\u578b\u9274\u5b9a\u3001\u8111\u6e17\u900f\u6027\u8bc4\u4ef7\u7b49\u3002\u7bc7\u5e45\u6240\u9650\uff0c\u5c31\u4e0d\u4e00\u4e00\u4ecb\u7ecd\u4e86\u3002<\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">&nbsp;<\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"color: rgb(217, 33, 66);\"><strong>DMPK\u7b5b\u9009\u7b56\u7565<\/strong><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u7b14\u8005\u8ba4\u4e3a\u5728\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u4e2d\uff0c\u96be\u70b9\u4e0d\u5728\u4e8e\u5efa\u7acb\u8bd5\u9a8c\u4f53\u7cfb\u548c\u5f00\u5c55\u3001\u5b8c\u6210\u76f8\u5e94\u7684\u5b9e\u9a8c\u5de5\u4f5c\uff0c\u800c\u5728\u4e8e\u6839\u636e\u4e0d\u540c\u7684\u9879\u76ee\u7279\u70b9\u5236\u5b9aDMPK\u7b5b\u9009\u7b56\u7565\uff0c\u4ee5\u53ca\u5982\u4f55\u89e3\u91ca\u548c\u5e94\u7528\u6570\u636e\u3002<\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">SureshK\u7b49[9]\u62a5\u9053\u4e86Millennium\u5728\u5148\u5bfc\u5316\u5408\u7269\u4f18\u5316\u548c\u5019\u9009\u5316\u5408\u7269\u9009\u62e9\u7684\u4f53\u5916\u4f53\u5185ADME\u7b56\u7565\uff0c\u89c1\u88686\u548c\u56fe5\u3002Gary W.\u7b49[10]\u62a5\u9053\u4e86R.W.Johnson\u5728\u65b0\u836f\u53d1\u73b0\u65e9\u671f\u548c\u540e\u671f\u5316\u5408\u7269\u4f18\u5316\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u8303\u4f8b\u3002Peter Ballard\u7b49[11]\u62a5\u9053\u4e86AstraZeneca\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u6574\u5408\u7684DMPK\u8bc4\u4ef7\u7b56\u7565\u3002Di Li\u7b49[12]\u9610\u8ff0\u4e86Pfizer \u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5CNS\u836f\u7269\u8111\u6e17\u900f\u6027\u7684\u8bc4\u4ef7\u53ca\u7b5b\u9009\u7b56\u7565\u3002<\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u901a\u8fc7\u7814\u7a76\u8fd9\u4e9bDMPK\u8bc4\u4ef7\u7b56\u7565\u53ef\u77e5\uff0c\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\uff0c\u6700\u91cd\u8981\u7684\u5c31\u662f\u5efa\u7acb\u4f53\u5916-\u4f53\u5185\u76f8\u5173\u6027\uff0c\u786e\u5b9aPK\/PD\u5173\u7cfb\uff0c\u6392\u9664\u4ee3\u8c22\u7269\u7684\u5b89\u5168\u6027\u98ce\u9669\uff0c\u63a8\u6d4b\u4eba\u4f53PK\u3001\u6cbb\u7597\u5242\u91cf\u53ca\u5b89\u5168\u7a97\u3002&nbsp;<\/p>\n<p><span style=\"font-size:16px;\">&nbsp;<\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size:16px;font-family:\u5b8b\u4f53;\">\u8868<\/span><span style=\"font-size:16px;\">6. <\/span><span style=\"font-size:16px;font-family:\u5b8b\u4f53;\">\u4e0d\u540c\u9636\u6bb5\u7684<\/span><span style=\"font-size:16px;\">ADME<\/span><span style=\"font-size:16px;font-family:\u5b8b\u4f53;\">\u5b9e\u9a8c<\/span><\/p>\n<p><img class=\"\"      style=\"width: 100%;height: auto;\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533785920.jpg\" alt=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\" title=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\"  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"width: 100%;height: auto;\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress2-1533785921.jpg\" alt=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\" title=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\"  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\">\u56fe5. \u4ece\u82d7\u5934\u5230\u5148\u5bfc\u53ca\u5148\u5bfc\u5316\u5408\u7269\u4f18\u5316\u7684\u8fed\u4ee3\u9014\u5f84<\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><br  \/><\/p>\n<p><img class=\"\"      style=\"width: 100%;height: auto;\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533785921.jpg\" alt=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\" title=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\"  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\">\u56fe6. \u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684ADME\u7b5b\u9009\u6d41\u7a0b\u53ca\u4e3b\u8981\u5b9e\u9a8c<\/p>\n<p style=\"text-align: center;line-height: 1.75em;\">&nbsp;<\/p>\n<p style=\"text-align: center;line-height: 1.75em;\">\u88687. \u5404\u8f6eDMPK\u6d4b\u8bd5\u7684\u5b9e\u9a8c\u53ca\u9884\u4f30\u5316\u5408\u7269\u6570\u91cf<\/p>\n<p><img class=\"\"      style=\"width: 100%;height: auto;\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress0-1533785921.png\" alt=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\" title=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\"  \/><\/p>\n<p><br  \/><\/p>\n<\/p>\n<p style=\"text-align: center;line-height: 1.75em;\">\u56fe7. CNS\u836f\u7269\u7b5b\u9009\u6d41\u7a0b<\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"margin-bottom: 0.1px;line-height: 150%;text-align: justify;\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<p style=\"margin-bottom: 0.1px;line-height: 150%;text-align: justify;\"><span style=\"font-size:13px;line-height:150%;\">[1]Daniela Schuster, Christian Laggner, Thierry Langer, Why drugsfail-a study on side effects in new chemical entities. Wiley\u2010VCH Verlag GmbH &amp; Co. KGaA ,&nbsp;2008,&nbsp;11 (27) :3545-59 <\/span><\/p>\n<p style=\"line-height: 150%;text-align: justify;\"><span style=\"font-size:13px;line-height:150%;\">[2]<\/span><span style=\"font-size:13px;line-height:150%;color:windowtext;\"> IsmailKola, John Landis,<\/span><span style=\"font-size:13px;line-height:150%;\">Can the pharmaceutical industry reduce attritionrates?<\/span><span style=\"font-size:13px;line-height:150%;\">Nature Reviews Drug Discovery,&nbsp;2004,&nbsp;3(8) :711-5.<\/span><\/p>\n<p style=\"line-height: 150%;text-align: justify;\"><span style=\"font-size:13px;line-height:150%;\">[3]<span style=\"letter-spacing:.20px;\"> John Arrowsmith,<em> <\/em><\/span><\/span><span style=\"font-size:13px;line-height:150%;letter-spacing:.20px;\">Trial watch: Phase IIfailures: 2008\u20132010. <\/span><em><span style=\"font-size:13px;line-height:150%;letter-spacing:.20px;\">Nature Reviews Drug Discovery<\/span><\/em><span style=\"font-size:13px;line-height:150%;letter-spacing:.20px;\"> 2011,10, 328\u2013329. <\/span><\/p>\n<p style=\"line-height: 150%;text-align: justify;\"><span style=\"font-size:13px;line-height:150%;letter-spacing:.20px;\">[4] John Arrowsmith,<em> <\/em><\/span><span style=\"font-size:13px;line-height:150%;\">Trial watch: phase III and submission failures: 2007-2010.<\/span><\/p>\n<p style=\"line-height: 150%;text-align: justify;\"><em><span style=\"font-size:13px;line-height:150%;letter-spacing:.20px;\">Nature Reviews Drug Discovery<\/span><\/em><span style=\"font-size:13px;line-height:150%;\">2011 Feb; 10 (2):87. <\/span><\/p>\n<p style=\"line-height: 150%;text-align: justify;\"><span style=\"font-size:13px;line-height:150%;\">[5] <\/span><span style=\"font-size:13px;line-height:150%;letter-spacing:.20px;\">John Arrowsmith,<\/span><span style=\"font-size:13px;line-height:150%;\">Trial Watch: Phase II and Phase III attrition rates2011-2012<\/span><span style=\"font-size:13px;line-height:150%;\">. Nature Reviews DrugDiscovery,&nbsp;2013,&nbsp;12 (8):569.<\/span><\/p>\n<p style=\"margin-bottom: 0.1px;line-height: 150%;text-align: justify;\"><span style=\"font-size:13px;line-height:150%;\">[6] <\/span><span style=\"font-size:13px;line-height:150%;\">RK Harrison,<\/span><span style=\"color: windowtext;font-size: 13px;line-height: 150%;\">Phase II and phase III failures: 2013-2015<\/span><span style=\"font-size: 13px;line-height: 150%;color: windowtext;\">.<\/span><span style=\"text-decoration: underline;font-size: 13px;line-height: 150%;color: blue;\">Nature Reviews Drug Discovery <\/span><span style=\"font-size: 13px;line-height: 150%;color: windowtext;\">,&nbsp;2016,&nbsp;15 (12):817. &nbsp;<\/span><span style=\"font-size:13px;line-height:150%;\">&nbsp;<\/span><\/p>\n<p style=\"margin-bottom: 0.1px;line-height: 150%;text-align: justify;\"><span style=\"font-size:13px;line-height:150%;\">[7] <\/span><span style=\"font-size:13px;line-height:150%;\">P Ballard,<\/span><span style=\"font-size:13px;line-height:150%;\">P Brassil,<\/span><span style=\"font-size:13px;line-height:150%;\">KH Bui etc. <\/span><span style=\"color: windowtext;text-decoration: underline;\"><span style=\"font-size:13px;line-height:150%;color:blue;\">The rightcompound in the right assay at the right time: an integrated discovery DMPKstrategy.<\/span><span style=\"font-size: 13px;line-height: 150%;color: blue;border-width: 1px;border-style: none;border-color: windowtext;padding: 0px;\">Drug Metabolism Reviews<\/span><\/span><span style=\"font-size: 13px;line-height: 150%;color: windowtext;border-width: 1px;border-style: none;border-color: windowtext;padding: 0px;\">,15 Jun 2012, 44(3):224-252<\/span><\/p>\n<p style=\"margin-bottom: 0.1px;line-height: 150%;text-align: justify;\"><span style=\"font-size:13px;line-height:150%;\">[8] Edward H.Kerns, Li Di. Drug like Properties: Concepts, Structure Design and Methods fromADME to Toxicity Optimization<\/span><\/p>\n<p style=\"margin-bottom: 0.1px;line-height: 150%;text-align: justify;\"><span style=\"font-size:13px;line-height:150%;\">[9] <\/span><span style=\"font-size:13px;line-height:150%;color:#333333;\">Balani SK<\/span><sup><span style=\"font-size: 13px;line-height: 150%;\">1<\/span><\/sup><span style=\"font-size: 13px;line-height: 150%;\">, <\/span><span style=\"font-size:13px;line-height:150%;color:#333333;\">Miwa GT<\/span><span style=\"font-size: 13px;line-height: 150%;\">, <\/span><span style=\"font-size:13px;line-height:150%;color:#333333;\">Gan LS<\/span><span style=\"font-size: 13px;line-height: 150%;\">, etc. Strategy of utilizing in vitro and in vivo ADME tools for leadoptimization and drug candidate selection.<\/span><\/p>\n<p style=\"margin-bottom: 0.1px;line-height: 150%;text-align: justify;\"><span style=\"font-size:13px;line-height:150%;color:#333333;\">Curr Top Med Chem.<\/span><span style=\"font-size: 13px;line-height: 150%;\"> 2005;5(11):1033-8.<\/span><\/p>\n<p style=\"line-height: 150%;text-align: justify;\"><span style=\"font-size:13px;line-height:150%;\">[10] <\/span><span style=\"font-size:13px;line-height:150%;color:#333333;\">CaldwellGW<\/span><sup><span style=\"font-size: 13px;line-height: 150%;\">1<\/span><\/sup><span style=\"font-size: 13px;line-height: 150%;\">, <\/span><span style=\"font-size:13px;line-height:150%;color:#333333;\">Ritchie DM<\/span><span style=\"font-size: 13px;line-height: 150%;\">, <\/span><span style=\"font-size:13px;line-height:150%;color:#333333;\">Masucci JA<\/span><span style=\"font-size: 13px;line-height: 150%;\">, etc. The new pre-preclinical paradigm: compoundoptimization in early and late phase drug discovery. <\/span><span style=\"font-size:13px;line-height:150%;color:#333333;\">Curr Top Med Chem.<\/span><span style=\"font-size: 13px;line-height: 150%;\"> 2001Nov;1(5):353-66.<\/span><\/p>\n<p style=\"line-height: 150%;text-align: justify;\"><span style=\"font-size: 13px;line-height: 150%;\">[11] <\/span><span style=\"font-size:13px;line-height:150%;color:#333333;\">Ballard P<\/span><span style=\"font-size: 13px;line-height: 150%;\">, <\/span><span style=\"font-size:13px;line-height:150%;color:#333333;\">Brassil P<\/span><span style=\"font-size: 13px;line-height: 150%;\">, <\/span><span style=\"font-size:13px;line-height:150%;color:#333333;\">Bui KH<\/span><span style=\"font-size: 13px;line-height: 150%;\">, etc. The right compound in the right assay at theright time: an integrated discovery DMPK strategy. <\/span><span style=\"font-size:13px;line-height:150%;color:#333333;\">Drug Metab Rev.<\/span><span style=\"font-size: 13px;line-height: 150%;\"> 2012Aug;44(3):224-52.<\/span><\/p>\n<p style=\"line-height: 150%;text-align: justify;\"><span style=\"font-size: 13px;line-height: 150%;\">[12] <\/span><span style=\"font-size:13px;line-height:150%;color:#333333;\">Di L<\/span><span style=\"font-size: 13px;line-height: 150%;\">, <\/span><span style=\"font-size:13px;line-height:150%;color:#333333;\">Rong H<\/span><span style=\"font-size: 13px;line-height: 150%;\">, <\/span><span style=\"font-size:13px;line-height:150%;color:#333333;\">Feng B<\/span><span style=\"font-size: 13px;line-height: 150%;\">. Demystifying Brain Penetration inCentral Nervous System Drug Discovery. <\/span><span style=\"font-size:13px;line-height:150%;color:#333333;\">J Med Chem.<\/span><span style=\"font-size: 13px;line-height: 150%;\"> 2013 Jan10;56(1):2-12.<\/span><\/p>\n<hr  \/>\n<p><span style=\"font-size:16px;font-family:\u5b8b\u4f53;\"><\/span><span style=\"font-size: 14px;background-color: rgb(255, 255, 255);\">\u6392\u7248\uff1a\u6885\u5e0c<\/span><\/p>\n<section style=\"max-width: 677px;box-sizing: border-box;word-wrap: break-word;color: rgb(51, 51, 51);\">\n<section style=\"padding-right: 10px;padding-left: 10px;max-width: 677px;box-sizing: border-box;word-wrap: break-word;background-color: rgb(208, 169, 115);display: inline-block;height: 40px;line-height: 40px;min-width: 17px;vertical-align: middle;\">\n<section style=\"max-width: 64px;box-sizing: border-box;word-wrap: break-word;color: rgb(255, 255, 255);font-size: 15px;height: 40px;min-width: 20px;\">\u5e7f\u800c\u544a\u4e4b<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: -21px;margin-left: 30px;padding-top: 20px;padding-bottom: 20px;max-width: 677px;box-sizing: border-box;word-wrap: break-word;color: rgb(51, 51, 51);\">\n<section style=\"margin-left: -20px;max-width: 645px;box-sizing: border-box;word-wrap: break-word;\">\n<p style=\"max-width: 645px;box-sizing: border-box;word-wrap: break-word;min-height: 17px;color: rgb(6, 6, 6);\"><span style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word;font-size: 15px;\">\u2299&nbsp;\u540c\u5199\u610f\u57f9\u8bad<\/span><\/p>\n<p style=\"max-width: 645px;box-sizing: border-box;word-wrap: break-word;min-height: 17px;\"><span style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word;color: rgb(172, 57, 255);font-size: 16px;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI5ODI5NDE2OA==&amp;mid=2247495740&amp;idx=2&amp;sn=5730f48e350b775d76fbe0f2ddb7b11d&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box;word-wrap: break-word;\">\u5199\u610f\u8bba\u575b\u4e28\u65b0\u836f\u4e2d\u7f8e\u53cc\u62a5\u4e4b\u5236\u5242\u6eb6\u51fa\u6280\u672f\u5f00\u53d1<\/a><\/span><\/p>\n<p style=\"max-width: 645px;box-sizing: border-box;word-wrap: break-word;min-height: 17px;\"><span style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word;color: rgb(172, 57, 255);font-size: 16px;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI5ODI5NDE2OA==&amp;mid=2247495753&amp;idx=2&amp;sn=86f8f5bdde6849a6e35848be58f4e1c6&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box;word-wrap: break-word;\">\u5199\u610f\u8bba\u575b\u4e28\u56fd\u9645\u89c4\u8303\u4e0b\u751f\u7269\u836f\u5168\u751f\u547d\u5468\u671f\u8d28\u91cf\u7ba1\u7406<\/a><\/span><\/p>\n<p style=\"max-width: 645px;box-sizing: border-box;word-wrap: break-word;min-height: 17px;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI5ODI5NDE2OA==&amp;mid=2247495790&amp;idx=2&amp;sn=718dd5d02dd76f06a4ef7064348a8fdb&amp;chksm=ecaabe99dbdd378f16da63761667e26cdac884284b6352d754af9b6523723de1f25563955685&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(172, 57, 255);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box;word-wrap: break-word;font-size: 16px;\">\u5199\u610f\u516c\u76ca\u4e28\u4eff\u5236\u836f\u4e00\u81f4\u6027\u8bc4\u4ef7\u5927\u76d8\u70b9\u4e0e\u603b\u51b3\u6218<\/a><\/p>\n<p style=\"max-width: 645px;box-sizing: border-box;word-wrap: break-word;min-height: 17px;\"><span style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word;color: rgb(172, 57, 255);font-size: 16px;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI5ODI5NDE2OA==&amp;mid=2247495872&amp;idx=2&amp;sn=7d69fb5141470023d3f7c4c4de5dbfcf&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box;word-wrap: break-word;\">\u6ee1\u8db3IND\/NDA\u4e2d\u7f8e\u53cc\u62a5\u7684\u53e3\u670d\u65b0\u836f\u5236\u5242\u7814\u53d1<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<hr style=\"max-width: 100%;box-sizing: border-box;color: rgb(51, 51, 51);\"  \/>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(51, 51, 51);\"><img width=\"auto\"    class=\"\"  style=\"max-width: 677px;box-sizing: border-box;word-wrap: break-word;visibility: visible !important;width: 366px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533785921.jpg\" alt=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\" title=\"\u5728\u65b0\u836f\u53d1\u73b0\u9636\u6bb5\u7684DMPK\u7b5b\u9009\u65b9\u6cd5\u53ca\u8bc4\u4ef7\u7b56\u7565\"  \/><\/p>\n<p style=\"max-width: 677px;box-sizing: border-box;word-wrap: break-word;min-height: 17px;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word;font-size: 15px;\">\u836f\u4e8b\u7eb5\u6a2a\u662f\u4e00\u4e2a\u5f00\u653e\uff0c\u7531\u81ea\u613f\u8005\u7ec4\u6210\u7684\u56e2\u4f53\uff0c\u73b0\u6709\u6210\u545831\u540d\uff0c\u5206\u522b\u4e3aVoyager88\uff08\u9b4f\u5229\u519b\uff09\uff0c\u96f7\u8bfa\u5c9b\uff0cHerman\uff0c\u6885\u5e0c\uff0c\u6587\u7af9\uff0cduke\uff0cyhqqqqq\uff0c\u5360\u5c0f\u5175\uff0c\u9526\u5fc3\u7ee3\u53e3\uff0cflydp511\uff0c\u5de7\u5de7\uff0c\u9621\u4e0a\u964c\u964c\uff0c\u591a\u5df4\u80fa\uff0c\u745c\u513f\uff0cKailyn\uff0cSeven\uff0c\u5b50\u708e\uff0c\u514b\u683c\u83ab\uff0cVicky\uff0cSophia \uff0c\u4f9d\u7136\u7279\u96f7\u897f\uff0c\u5076\u9635\u96e8\uff0cAimee\uff0c\u4ed6\u5c71\u4e4b\u77f3\uff0c\u96f6\u4e0b274\u2103\uff0cBreathless\uff0cLuffy\uff0c\u80e1\u4e0d\u559c\uff0c&nbsp;Helen\uff0c\u843d\u843d\uff0cSUNRISE\u3002\u6b22\u8fce\u6709\u5fd7\u4e4b\u58eb\u52a0\u5165\u6211\u4eec\u56e2\u961f\u3002\u6295\u7a3f\u3001\u5408\u4f5c\u3001\u52a0\u4e13\u4e1a\u7fa4\u8bf7\u52a0\u5fae\u4fe1442015666\uff0c\u836f\u4e8b\u7eb5\u6a2a\u4e8c\u5343\u4ebaQQ\u7fa422711855\u3002<\/span><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u4e8b\u7eb5\u6a2a                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u836f\u4ee3\u52a8\u529b\u5b66\uff08Drug metabolism and Pharmacokinetics\uff09\u662f\u5b9a\u91cf\u7814\u7a76\u836f\u7269\u5728\u751f\u7269\u4f53\u5185 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