{"id":28390,"date":"2018-08-08T01:00:00","date_gmt":"2018-08-09T03:55:18","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e8%a5%bf%e6%b9%96%e5%a4%a7%e5%ad%a6%e6%9c%89%e6%9c%ba%e5%8c%96%e5%ad%a6%e7%9f%b3%e8%88%aa%e8%af%be%e9%a2%98%e7%bb%84%e9%ab%98%e8%96%aa%e6%8b%9b%e8%81%98%e5%90%af%e4%ba%8b\/"},"modified":"2018-08-09T11:55:20","modified_gmt":"2018-08-09T03:55:20","slug":"%e8%a5%bf%e6%b9%96%e5%a4%a7%e5%ad%a6%e6%9c%89%e6%9c%ba%e5%8c%96%e5%ad%a6%e7%9f%b3%e8%88%aa%e8%af%be%e9%a2%98%e7%bb%84%e9%ab%98%e8%96%aa%e6%8b%9b%e8%81%98%e5%90%af%e4%ba%8b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/28390\/","title":{"rendered":"\u897f\u6e56\u5927\u5b66\u6709\u673a\u5316\u5b66\u77f3\u822a\u8bfe\u9898\u7ec4\u9ad8\u85aa\u62db\u8058\u542f\u4e8b"},"content":{"rendered":"
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\"\u897f\u6e56\u5927\u5b66\u6709\u673a\u5316\u5b66\u77f3\u822a\u8bfe\u9898\u7ec4\u9ad8\u85aa\u62db\u8058\u542f\u4e8b\"<\/p>\n


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2008\u20122013\u5e74\u5728\u5317\u4eac\u5927\u5b66\u653b\u8bfb\u6709\u673a\u5316\u5b66\u535a\u58eb\u5b66\u4f4d\uff0c\u5e08\u4ece\u6768\u9707\u6559\u6388\u30022013\u20122015\u5e74\u5728\u7f8e\u56fdHarvard\u5927\u5b66Tobias Ritter\u6559\u6388\uff08\u73b0\u4e3a\u5fb7\u56fdMax-Planck-Institut f\u00fcr Kohlenforschung\u7814\u7a76\u6240\u7684Managing Director\uff09\u8bfe\u9898\u7ec4\u4ece\u4e8b\u535a\u540e\u7814\u7a76\u3002\u5176\u95f4\u5728\u7f8e\u56fdMassachusetts General Hospital\u4ece\u4e8b\u653e\u5c04\u5316\u5b66\u7814\u7a76\uff0c\u6307\u5bfc\u6559\u5e08\u4e3aTobias Ritter\u6559\u6388\u3001Neil Vasdev\u6559\u6388\uff08\u73b0\u4e3a\u52a0\u62ff\u5927Toronto\u5927\u5b66Neuro-Radiochemistry\u4e2d\u5fc3\u7684Director\u53caCampbell Family Mental Health\u7814\u7a76\u6240\u7684Associate Director\u3001Chief Radiochemist\uff09\u548cSteven H. Liang\u6559\u6388\u30022015\u20122018\u5e74\u5728\u7f8e\u56fdScripps\u7814\u7a76\u6240Jin-Quan Yu\u6559\u6388\u8bfe\u9898\u7ec4\u4ece\u4e8b\u535a\u58eb\u540e\u7814\u7a76\u3002\u7814\u7a76\u9886\u57df\u6d89\u53ca\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u3001\u91d1\u5c5e\u6709\u673a\u65b9\u6cd5\u5b66\u3001\u4e0d\u5bf9\u79f0\u50ac\u5316\u53caF-18\u653e\u5c04\u5316\u5b66\uff0c\u5e76\u5c06\u4e8e2018\u5e74\u5168\u804c\u56de\u5230\u897f\u6e56\u5927\u5b66\u7406\u5b66\u7814\u7a76\u6240\u62c5\u4efb\u7814\u7a76\u5458\u3002<\/span><\/p>\n


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\u4ee3\u8868\u8bba\u6587\uff08\u535a\u58eb\u3001\u535a\u58eb\u540e\u9636\u6bb5\uff09<\/strong><\/span><\/p>\n

1. Shi, H.; Herron, A. N.; Shao, Y.; Shao, Q.; Yu, J.-Q. \u201cEnantioselective remote meta<\/em>-C\u2012H arylation and alkylation via a chiral transient mediator\u201d Nature<\/em>, 2018<\/strong>, 558<\/em>, 581.<\/span><\/p>\n

2. Shi, H.; Wang, P.; Suzuki, S.; Farmer, M. E.; Yu, J.-Q. \u201cLigand promoted meta<\/em>-C\u2212H chlorination of anilines and phenols\u201d J. Am. Chem. Soc<\/em>., 2016<\/strong>, 138<\/em>, 14876.<\/span><\/p>\n

3. Shi, H.; Braun, A.; Wang, L.; Liang, S. H.; Vasdev, N.; Ritter, T. \u201cSynthesis of <\/span>18<\/sup><\/span>F-difluoromethylarenes from aryl (pseudo) halides\u201d Angew. Chem. Int. Ed<\/em>., 2016<\/strong>, 55<\/em>, 10786.<\/span><\/p>\n

4. Shi, H.; Tan, C.; Zhang, W.; Long, R.; Gong, J.; Luo, T.; Yang, Z. \u201cGold-catalyzed enantio- and diastereoselective syntheses of left-wing fragments of azadirachtin\/meliacarpin-type limonoids\u201d J. Org. Chem.<\/em>, 2016<\/strong>, 81<\/em>, 751.<\/span><\/p>\n

5. Shi, H.; Babinski, D.; Ritter, T. \u201cModular C\u2212H functionalization cascade of aryl iodides\u201d J. Am. Chem. Soc.<\/em>, 2015<\/strong>, 137<\/em>, 3775. <\/span><\/p>\n

6. Shi, H.; Tan, C.; Zhang, W.; Zhang, Z.; Long, R.; Luo, T.; Yang, Z. \u201cSynthetic progress toward azadirachtins. 1. enantio- and diastereoselective synthesis of the left-wing fragment of 11-epi<\/em>-azadirachtin I\u201d Org. Lett.<\/em>, 2015<\/strong>, 17<\/em>, 2342.<\/span><\/p>\n

7. Shi, H.; Fang, L.; Tan, C.; Shi, L.; Zhang, W.; Li, C.-C.; Luo, T.; Yang, Z. \u201cTotal syntheses of drimane-type sesquiterpenoids enabled by a gold-catalyzed tandem reaction\u201d J. Am. Chem. Soc<\/em>., 2011<\/strong>, 133<\/em>, 14944.<\/span><\/p>\n


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1. \u8fc7\u6e21\u91d1\u5c5e\u914d\u5408\u7269<\/span><\/p>\n

2. \u6709\u673a\u50ac\u5316\u53cd\u5e94<\/span><\/p>\n

3. \u6d3b\u6027\u5c0f\u5206\u5b50\u63a2\u9488\u5408\u6210<\/span><\/p>\n

4. \u529f\u80fd\u6750\u6599\u5206\u5b50\u5408\u6210<\/span><\/p>\n


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1. \u535a\u58eb\u751f\uff08\u591a\u540d\uff09\uff1a<\/strong><\/span>\u9488\u5bf9\u672c\u79d1\u3001\u7855\u58eb\u6bd5\u4e1a\u751f\uff0c\u91c7\u7528\u4e0e\u590d\u65e6\u5927\u5b66\u6216\u8005\u6d59\u6c5f\u5927\u5b66\u8054\u5408\u57f9\u517b\u6a21\u5f0f\uff0c\u6bd5\u4e1a\u540e\u53d1\u6d59\u5927\u6216\u8005\u590d\u65e6\u7684\u535a\u58eb\u6bd5\u4e1a\u8bc1\u548c\u5b66\u4f4d\u8bc1\uff08\u6709\u673a\u5316\u5b66\u4e13\u4e1a\uff09\u3002\u5f55\u53d6\u65b9\u5f0f\uff1a1\u3001\u901a\u8fc7\u201c\u7533\u8bf7\u2012\u8003\u6838\u201d\u5236\u5f55\u53d6\uff0c\u4e0d\u9700\u53c2\u52a0\u5168\u56fd\u7814\u7a76\u751f\u62db\u751f\u7edf\u4e00\u8003\u8bd5\uff1b2\u3001\u4fdd\u9001\u5236\u5ea6\uff0c\u6bcf\u5e74\u7ec4\u7ec7\u590f\u4ee4\u8425\u9762\u8bd5\u5177\u6709\u4fdd\u9001\u8d44\u683c\u7684\u672c\u79d1\u751f\uff0c\u62e9\u4f18\u5f55\u53d6\u3002\u63d0\u4f9b\u7279\u522b\u4f18\u539a\u7684\u5de5\u8d44\u5f85\u9047\u548c\u8865\u52a9\uff08\u4e0e\u5177\u6709\u7855\u58eb\u5b66\u4f4d\u7684\u79d1\u7814\u52a9\u7406\u5f85\u9047\u76f8\u5f53\u6216\u66f4\u9ad8\uff0c\u5177\u4f53\u60c5\u51b5\u9762\u8bae\uff09\u3002<\/span><\/p>\n


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2. \u526f\u7814\u7a76\u5458\uff08\u591a\u540d\uff09\uff1a<\/strong><\/span>\uff08\u591a\u540d\uff09\uff1a\u62db\u6536\u5177\u6709\u91d1\u5c5e\u6709\u673a\u914d\u5408\u7269\u3001\u6709\u673a\u65b9\u6cd5\u5b66\u3001\u5929\u7136\u4ea7\u7269\u5408\u6210\u53ca\u6709\u673a\u6750\u6599\u7b49\u76f8\u5173\u7814\u7a76\u80cc\u666f\u7684\u535a\u58eb\u7814\u7a76\u4eba\u5458\uff08\u5177\u67092\u5e74\u53ca\u4ee5\u4e0a\u535a\u540e\u7ecf\u5386\uff09\uff0c\u63d0\u4f9b\u7279\u522b\u4f18\u539a\u7684\u4e2a\u4eba\u5f85\u9047\u548c\u8865\u52a9\uff08\u5177\u4f53\u60c5\u51b5\u9762\u8bae\uff09\u3002<\/span><\/p>\n


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3. \u52a9\u7406\u7814\u7a76\u5458\uff08\u591a\u540d\uff09\uff1a<\/strong><\/span>\u62db\u6536\u5177\u6709\u91d1\u5c5e\u6709\u673a\u914d\u5408\u7269\u3001\u6709\u673a\u65b9\u6cd5\u5b66\u3001\u5929\u7136\u4ea7\u7269\u5408\u6210\u53ca\u6709\u673a\u6750\u6599\u7b49\u76f8\u5173\u7814\u7a76\u80cc\u666f\u7684\u535a\u58eb\u6bd5\u4e1a\u751f\uff0c\u63d0\u4f9b\u7279\u522b\u4f18\u539a\u7684\u4e2a\u4eba\u5f85\u9047\u548c\u8865\u52a9\uff08\u5177\u4f53\u60c5\u51b5\u9762\u8bae\uff09\u3002<\/span><\/p>\n


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4. \u79d1\u7814\u52a9\u7406\uff08\u591a\u540d\uff09\uff1a<\/strong><\/span>\u62db\u6536\u5177\u6709\u76f8\u5173\u4e13\u4e1a\u80cc\u666f\u7684\u672c\u79d1\u3001\u7855\u58eb\u6bd5\u4e1a\u751f\uff08\u6709\u610f\u653b\u8bfb\u897f\u6e56\u5927\u5b66\u535a\u58eb\u5b66\u4f4d\u8005\uff09\uff0c\u63d0\u4f9b\u4f18\u539a\u7684\u4e2a\u4eba\u5f85\u9047\u548c\u8865\u52a9\uff08\u5177\u4f53\u60c5\u51b5\u9762\u8bae\uff09\u3002<\/span><\/p>\n


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5. \u884c\u653f\u52a9\u7406\uff081\u540d\uff09\uff1a<\/strong><\/span>\u62db\u6536\u5177\u6709\u76f8\u5173\u4e13\u4e1a\u80cc\u666f\u7684\u7855\u58eb\u6bd5\u4e1a\u751f\uff08\u5177\u6709\u5904\u7406\u884c\u653f\u4e8b\u52a1\u3001\u4e2d\u82f1\u6587\u5199\u4f5c\u53ca\u82f1\u6587\u4ea4\u6d41\u80fd\u529b\uff09\uff0c\u63d0\u4f9b\u4f18\u539a\u7684\u4e2a\u4eba\u5f85\u9047\u548c\u8865\u52a9\uff08\u5177\u4f53\u60c5\u51b5\u9762\u8bae\uff09\u3002<\/span><\/p>\n


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\u897f\u6e56\u5927\u5b66\u7406\u5b66\u7814\u7a76\u6240\u5177\u6709\u4e16\u754c\u4e00\u6d41\u7684\u79d1\u7814\u5e73\u53f0\u3001\u5de5\u4f5c\u73af\u5883\u3002\u672c\u8bfe\u9898\u7ec4\u5c06\u4e3a\u7ec4\u5458\uff1a1\u3001\u5c3d\u529b\u63d0\u4f9b\u4f18\u539a\u7684\u5f85\u9047\uff08\u6211\u4eec\u6df1\u523b\u7406\u89e3\u5de5\u8d44\u5f85\u9047\u5bf9\u4e8e\u7ec4\u5458\u751f\u6d3b\u7684\u91cd\u8981\u6027\uff0c\u5e76\u80fd\u591f\u63d0\u4f9b\u8db3\u591f\u6ee1\u610f\u7684\u6761\u4ef6\uff0c\u9650\u4e8e\u591a\u65b9\u9762\u8003\u8651\uff0c\u4e0a\u8ff0\u4fe1\u606f\u65e0\u6cd5\u5728\u6b64\u5199\u660e\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u53ef\u5728\u9762\u8bae\u65f6\u534f\u5546\uff09\uff1b2\u3001\u91cd\u70b9\u8003\u8651\u53d1\u8868\u9ad8\u6c34\u5e73\u79d1\u7814\u6210\u679c\u7684\u9700\u6c42\uff1b3\u3001\u652f\u6301\u4f5c\u4e3a\u9879\u76ee\u8d1f\u8d23\u4eba\u7533\u8bf7\u5404\u7c7b\u57fa\u91d1\u53ca\u4eba\u624d\u8ba1\u5212\uff1b4\u3001\u63a8\u8350\u6709\u610f\u613f\u8005\u5230\u6d77\u5916\u7ee7\u7eed\u4ea4\u6d41\u6df1\u9020\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6211\u4eec\u975e\u5e38\u6b22\u8fce\u5177\u6709\u79d1\u7814\u7406\u60f3\u3001\u521b\u65b0\u80fd\u529b\u3001\u52e4\u594b\u52aa\u529b\u7684\u540c\u5b66\u548c\u6709\u5fd7\u4e4b\u58eb\u52a0\u5165\u672c\u8bfe\u9898\u7ec4\u3002\u6709\u610f\u5411\u8005\u8bf7\u5c06\u7533\u8bf7\u4e66\u53d1\u9001\u5230\u4ee5\u4e0b\u90ae\u7bb1\uff0c\u5e76\u6ce8\u660e\u5e94\u8058\u5c97\u4f4d+\u59d3\u540d\u3002\u7533\u8bf7\u4e66\u5e94\u5305\u542b\u4e2a\u4eba\u7b80\u4ecb\u3001\u7ecf\u5386\u3001\u7814\u7a76\u5c0f\u7ed3\u3001\u4ee3\u8868\u6027\u8bba\u6587\u3001\u63a8\u8350\u4eba\u8054\u7cfb\u65b9\u5f0f\u7b49\u3002\u672c\u79d1\u751f\u6709\u610f\u8bfb\u535a\u8005\u53ef\u5c06\u4e2a\u4eba\u7b80\u4ecb\u53d1\u5230\u4ee5\u4e0b\u90ae\u7bb1\u3002\u6b22\u8fce\u5230\u897f\u6e56\u5927\u5b66\u5b9e\u5730\u8003\u5bdf\u4ea4\u6d41\u3002<\/span><\/p>\n


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\u8054\u7cfb\u65b9\u5f0f\uff1ashihang@wias.org.cn<\/strong><\/span><\/span><\/p>\n


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\u4e86\u89e3\u5728X-MOL\u53d1\u5e03<\/span><\/strong>\u62db\u8058\u4fe1\u606f<\/span><\/strong><\/span>\u7684\u8be6\u7ec6\u6d41\u7a0b\uff0c\u8bf7\u5782\u8be2<\/span><\/strong>service@x-mol.com<\/strong><\/span><\/p>\n


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<\/span>\"\u897f\u6e56\u5927\u5b66\u6709\u673a\u5316\u5b66\u77f3\u822a\u8bfe\u9898\u7ec4\u9ad8\u85aa\u62db\u8058\u542f\u4e8b\"<\/p>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a X\u4e00MOL\u8d44\u8baf <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u77f3\u822a\u7814\u7a76\u5458\u7b80\u4ecb 2008\u20122013\u5e74\u5728\u5317\u4eac\u5927\u5b66\u653b\u8bfb\u6709\u673a\u5316\u5b66\u535a\u58eb\u5b66\u4f4d\uff0c\u5e08\u4ece\u6768\u9707\u6559\u6388\u30022013\u20122015\u5e74\u5728\u7f8e\u56fdH […]<\/p>\n","protected":false},"author":1,"featured_media":28391,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/28390"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=28390"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/28390\/revisions"}],"predecessor-version":[{"id":28398,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/28390\/revisions\/28398"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/28391"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=28390"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=28390"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=28390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}