{"id":28416,"date":"2018-08-07T01:00:00","date_gmt":"2018-08-09T03:55:27","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e9%92%b4%e5%82%ac%e5%8c%96%e5%86%85%e7%82%94%e5%8f%82%e4%b8%8e%e7%9a%84%e7%94%b5%e5%8c%96%e5%ad%a6%e6%b0%a7%e5%8c%96c-h-n-h%e9%94%ae%e6%b4%bb%e5%8c%96\/"},"modified":"2018-08-09T11:55:32","modified_gmt":"2018-08-09T03:55:32","slug":"%e9%92%b4%e5%82%ac%e5%8c%96%e5%86%85%e7%82%94%e5%8f%82%e4%b8%8e%e7%9a%84%e7%94%b5%e5%8c%96%e5%ad%a6%e6%b0%a7%e5%8c%96c-h-n-h%e9%94%ae%e6%b4%bb%e5%8c%96","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/28416\/","title":{"rendered":"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;\"><span style=\"line-height: 0px;\">\u200d\u200d<\/span><span style=\"font-size: 18.018px;line-height: 0px;\">\u200d<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657590253&amp;idx=1&amp;sn=af64055348b35e9185b67c634d7ef95c&amp;chksm=80f7b23db7803b2bc868baa456f16ab2329ba355b97bce33703e32440ef4260a6f34c1ea970a&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-align: center;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;right: auto;bottom: auto;\"><img class=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress4-1533786928.gif\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/span><\/a><\/span><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwOTExNzg4Nw==&amp;mid=2657574730&amp;idx=1&amp;sn=7001a26433acb77dcdd5629f27cd8b20&amp;chksm=80f7769ab780ff8cedab5baefd9bc7a02dd18b2191cd29afb2d190e8ea149564133c9437e7d5&amp;scene=21#wechat_redirect\" target=\"_blank\"><\/a><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u7535\u50ac\u5316\u53cd\u5e94\u53ef\u4ee5\u907f\u514d\u5728\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u4f7f\u7528\u6210\u672c\u8f83\u9ad8\u7684\u5316\u5b66\u8bd5\u5242\uff0c\u51cf\u5c11\u4e0d\u5fc5\u8981\u7684\u526f\u4ea7\u7269\u4ea7\u751f\u3002\u8fd1\u5e74\u6765\uff0c\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u4e0e\u7535\u5316\u5b66\u5408\u6210\u7ed3\u5408\u5b9e\u73b0C-H\u952e\u7684\u6d3b\u5316\u53cd\u5e94\u53d6\u5f97\u4e86\u76f8\u5f53\u5927\u7684\u8fdb\u5c55\u3002Pd\u50ac\u5316\u4f53\u7cfb\u5728\u52a0\u70ed\u6761\u4ef6\u4e0b\u7ed3\u5408\u7535\u5316\u5b66\u624b\u6bb5\u5b9e\u73b0\u4ee5\u4e0a\u8fc7\u7a0b\u5df2\u53d1\u5c55\u5f97\u8f83\u4e3a\u6210\u719f\u30022017\u5e74\uff0c<strong>\u5fb7\u56fd\u54e5\u5ef7\u6839\u5927\u5b66\u5316\u5b66\u7cfb<\/strong>\u7684<strong>Lutz Ackermann<\/strong>\u6559\u6388\u8bfe\u9898\u7ec4\u53d1\u5c55\u4e86\u5ec9\u4ef7\u7684Co\u50ac\u5316\u4f53\u7cfb\uff0c\u5728\u4e0d\u52a0\u5165\u5176\u5b83\u6c27\u5316\u5242\u7684\u60c5\u51b5\u4e0b\u5b9e\u73b0\u4e86\u7535\u5316\u5b66\u6c27\u5316\u7684C-H\u952e\u6d3b\u5316\u8fc7\u7a0b\uff0c\u82b3\u57fa\u7532\u9170\u80fa\u4e0e\u7aef\u7094\u53ef\u4ee5\u53d1\u751f\u6b65\u9aa4\u7ecf\u6d4e\u6027\u7684[4+2]\u73af\u5316\u53cd\u5e94\u3002\u57fa\u4e8e\u5bf9C-H\u952e\u70f7\u6c27\u57fa\u5316\u53cd\u5e94\u7684\u673a\u7406\u7814\u7a76\uff0c\u4f5c\u8005\u9610\u660e\u4e86C-H\/N-H\u952e\u6d3b\u5316\u7684\u8fc7\u7a0b\uff0c\u4f46\u7094\u7c7b\u5e95\u7269\u8fd8\u5c40\u9650\u4e8e\u7aef\u7094\uff0c\u53d1\u5c55\u5185\u7094\u53c2\u4e0e\u7684\u53cd\u5e94\u4ecd\u7136\u975e\u5e38\u91cd\u8981\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress2-1533786928.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe1. \u7aef\u7094\u53c2\u4e0e\u7684[4+2]\u73af\u5316\u53cd\u5e94\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u8fd1\u65e5\uff0c\u8be5\u8bfe\u9898\u7ec4\u53c8\u5728<strong><em>J. Am. Chem. Soc.<\/em><\/strong>\u4e0a\u53d1\u8868\u6587\u7ae0\uff0c<strong>\u4ecd\u65e7\u4ee5\u94b4\u76d0\u4f5c\u4e3a\u50ac\u5316\u5242\uff0c\u901a\u8fc7\u7535\u5316\u5b66\u6c27\u5316\u7684C-H\/N-H\u952e\u6d3b\u5316\u5b9e\u73b0\u4e86\u82b3\u57fa\u7532\u9170\u80bc\u5bf9\u5185\u7094\u7684[4+2]\u73af\u5316\u53cd\u5e94<\/strong>\u3002\u7535\u5316\u5b66\u6c27\u5316C-H\u952e\u6d3b\u5316\u53ef\u4ee5\u5728\u5ba4\u6e29\u7684\u53cd\u5e94\u6761\u4ef6\u4e0b\u8fdb\u884c\uff0cH<\/span><span style=\"font-size: 14px;\"><sub>2<\/sub><\/span><span style=\"font-size: 18px;\">\u662f\u552f\u4e00\u7684\u526f\u4ea7\u7269\u3002\u8be5\u53cd\u5e94\u6210\u529f\u7684\u5173\u952e\u5728\u4e8e<em>N<\/em>-2-\u5421\u5576\u57fa\u80bc\u7ed3\u6784\u7684\u5f15\u5165\u3002\u4f5c\u8005\u8fd8\u5728\u5ba4\u6e29\u6761\u4ef6\u4e0b\u6210\u529f\u901a\u8fc7\u7535\u5316\u5b66\u8fd8\u539f\u3001\u9490\u50ac\u5316\u7684\u88c2\u89e3\u8fc7\u7a0b\u6d88\u9664\u4ea7\u7269\u4e2d\u8f85\u57fa\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533786928.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe2. \u7535\u5316\u5b66\u6c27\u5316\u3001\u94b4\u50ac\u5316\u7684C-H\/N-H\u952e\u6d3b\u5316\u53cd\u5e94\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u4f5c\u8005\u9996\u5148\u63a2\u7d22\u4e862-\u5421\u5576-\u82ef\u7532\u9170\u80bc<strong>1a<\/strong>\u5bf9\u5185\u7094<strong>2a<\/strong>\u7535\u5316\u5b66\u6c27\u5316[4+2]\u73af\u5316\u7684\u53cd\u5e94\u6761\u4ef6\u3002\u7ecf\u8fc7\u5927\u91cf\u7684\u6761\u4ef6\u7b5b\u9009\uff0c\u4f5c\u8005\u53d1\u73b0\u4ee5TFE\u4f5c\u4e3a\u6eb6\u5242\uff0cNaOPiv\u4f5c\u4e3a\u6dfb\u52a0\u5242\uff08entry 1-4\uff09\u53ef\u4ee5\u5f97\u5230\u9884\u671f\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\u952e\u6d3b\u5316\u7684\u4ea7\u7269\u3002\u53cd\u5e94\u6e29\u5ea6\u4e3a23 \u00b0C\uff08entry 4-6\uff09\u65f6\uff0cC-H\/N-H\u952e\u5373\u53ef\u53d1\u751f\u6709\u6548\u7684\u6d3b\u5316\u3002\u5f53\u4e19\u620a\u9178\u4f5c\u4e3a\u6dfb\u52a0\u5242\uff08entry 7-11\uff09\u65f6\uff0c\u4f53\u7cfb\u7684\u50ac\u5316\u6027\u80fd\u53ef\u8fdb\u4e00\u6b65\u63d0\u9ad8\uff0c\u4f53\u7cfb\u4e2d\u52a0\u5165\u7279\u620a\u9178\u4f5c\u4e3a\u6dfb\u52a0\u5242\u53ef\u4ee5\u63d0\u9ad8\u5e95\u7269\u6eb6\u7684\u89e3\u5ea6\u548c\u5316\u5b66\u9009\u62e9\u6027\uff0c\u5e76\u5b9e\u73b0\u66f4\u6709\u6548\u7684\u9634\u6781\u8fd8\u539f\uff0c\u4f7f\u50ac\u5316\u6027\u80fd\u5f97\u5230\u8fdb\u4e00\u6b65\u6539\u5584\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533786928.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe3. \u53cd\u5e94\u6761\u4ef6\u7684\u7b5b\u9009\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u4f5c\u8005\u8fd8\u63a2\u8ba8\u4e86\u82ef\u7532\u9170\u80fa\u5e95\u7269\u4e2d<em>N<\/em>-\u53d6\u4ee3\u57fa\u5728\u53cd\u5e94\u4e2d\u7684\u4f5c\u7528\u3002\u7ecf\u5e38\u4f7f\u7528\u7684N\u5bfc\u5411\u57fa\u56e2\uff0c\u59828-\u55b9\u5549\u57fa\u62162-<em>N<\/em>-\u6c27\u5421\u5576\u57fa\u53d6\u4ee3\u57fa\u90fd\u4e0d\u80fd\u4f7f\u5185\u7094<strong>2a<\/strong>\u53d1\u751f\u8f6c\u5316\uff0c\u4ec52-\u5421\u5576\u9170\u80bc<strong>1a<\/strong>\u53ef\u5f97\u5230\u76f8\u5e94\u7684C-H\/N-H\u952e\u6d3b\u5316\u4ea7\u7269\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533786928-1.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe4. <em>N<\/em>-\u53d6\u4ee3\u57fa\u5728\u53cd\u5e94\u4e2d\u7684\u4f5c\u7528\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u6709\u4e86\u6700\u4f73\u7684\u53cd\u5e94\u6761\u4ef6\uff0c\u4f5c\u8005\u5bf9\u5185\u7094\u5e95\u7269\u7684\u9002\u7528\u8303\u56f4\u8fdb\u884c\u4e86\u8003\u5bdf\u3002\u5bf9\u4e8e\u4e8c\u53d6\u4ee3\u7684\u4e59\u7094\uff0c\u53d6\u4ee3\u57fa\u53ef\u4ee5\u662f\u4fee\u9970\u7ed9\u7535\u5b50\u6216\u8005\u5438\u7535\u5b50\u57fa\u56e2\u7684\u82b3\u57fa\u3001\u70f7\u57fa\uff0c\u751a\u81f3\u916f\u57fa\uff0c\u53cd\u5e94\u90fd\u53ef\u4ee5\u987a\u5229\u8f6c\u5316\u5f97\u5230\u76f8\u5e94\u7684[4+2]\u73af\u5316\u4ea7\u7269\u3002\u7535\u5316\u5b66\u6c27\u5316\u7684C-H\/N-H\u952e\u6d3b\u5316\u5728\u5ba4\u6e29\u6761\u4ef6\u4e0b\u5c31\u53ef\u4ee5\u6709\u6548\u5730\u53d1\u751f\u3002NMR\u5b9e\u9a8c\u7814\u7a76\u8868\u660e\uff0c\u975e\u5bf9\u79f0\u53d6\u4ee3\u7684\u7094\u70c3<strong>2g-2i<\/strong>\u7684\u73af\u5316\u5177\u6709\u826f\u597d\u7684\u533a\u57df\u9009\u62e9\u6027\uff08\u56fe5b\uff09\u3002\u8be5\u53cd\u5e94\u8fd8\u9002\u7528\u4e8e\u82b3\u9999\u70c3<strong>1b-1m<\/strong>\u7684\u4f4d\u70b9\u9009\u62e9\u6027\u5b98\u80fd\u5316\uff08\u56fe5c\uff09\u3002\u5e38\u89c1\u7684\u4eb2\u7535\u5b98\u80fd\u56e2\u90fd\u53ef\u4ee5\u517c\u5bb9\uff0c\u5305\u62ec\u916f\u57fa\u3001\u6c2f\u3001\u6eb4\u3001\u7898\u548c\u6c30\u57fa\u53d6\u4ee3\u57fa\uff0c\u8fd9\u5bf9\u4e8e\u4ea7\u7269\u7684\u8fdb\u4e00\u6b65\u591a\u6837\u6027\u884d\u751f\u5316\u662f\u975e\u5e38\u6709\u4ef7\u503c\u7684\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress4-1533786928-1.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress6-1533786929.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe5. \u5185\u7094\u5e95\u7269\u9002\u7528\u8303\u56f4\u7684\u8003\u5bdf\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc<\/em>.<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u8fd9\u79cd\u7535\u5316\u5b66\u6c27\u5316\u7684C-H\/N-H\u952e\u6d3b\u5316\u8fc7\u7a0b\u4e0d\u4ec5\u4ec5\u9650\u4e8e\u5185\u7094\u70c3<strong>2<\/strong>\uff0c\u5404\u79cd\u672b\u7aef\u7094\u70c3<strong>7<\/strong>\u4e5f\u540c\u6837\u9002\u7528\uff08\u56fe6\uff09\u3002\u8bb8\u591a\u82b3\u57fa\u53d6\u4ee3\u7684\u7094\u70c3\u4e5f\u662f\u5408\u9002\u7684\u5e95\u7269\u3002\u5bf9\u6c27\u5316\u6761\u4ef6\u654f\u611f\u7684\u567b\u5429\u7ed3\u6784\u4e5f\u80fd\u5f88\u597d\u5730\u517c\u5bb9\uff0c\u6c22\u4f4d\u4e8e\u6c2e\u7684\u8fdc\u7aef\u65f6\u53cd\u5e94\u5177\u6709\u6781\u597d\u7684\u533a\u57df\u9009\u62e9\u6027\u3002\u7a7a\u95f4\u4f4d\u963b\u5927\u7684\u53d4\u4e01\u57fa\u7094<strong>7q<\/strong>\u4e5f\u662f\u7406\u60f3\u7684\u5e95\u7269\uff0c\u70f7\u57fa\u8148<strong>7r<\/strong>\u4e5f\u53ef\u987a\u5229\u53c2\u4e0e\u53cd\u5e94\uff0c\u6ca1\u6709\u4eb2\u6838\u8fdb\u653b\u7684\u526f\u53cd\u5e94\u53d1\u751f\u3002\u8be5\u53cd\u5e94\u8fd8\u53ef\u4ee5\u8fdb\u4e00\u6b65\u5b9e\u73b0\u5384\u6d1b\u66ff\u5c3c\uff08erlotinib\uff09\u884d\u751f\u7269<strong>8at<\/strong>\u7684\u540e\u671f\u591a\u6837\u5316\u8f6c\u5316\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress0-1533786929.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe6. \u7aef\u7094\u5e95\u7269\u9002\u7528\u8303\u56f4\u7684\u8003\u5bdf\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u4f5c\u8005\u8fd8\u5bf9\u53cd\u5e94\u7684\u673a\u7406\u8fdb\u884c\u4e86\u63a2\u7a76\u3002\u5206\u5b50\u95f4\u7684\u7ade\u4e89\u5b9e\u9a8c\u8868\u660e\u5bcc\u7535\u5b50\u82b3\u9999\u70c3<strong>1<\/strong>\u53c2\u4e0e\u53cd\u5e94\u66f4\u5177\u6709\u4f18\u52bf\uff0c\u8be5\u7ed3\u679c\u4e0e\u534f\u540c\u7684\u91d1\u5c5e\u5316-\u53bb\u8d28\u5b50\u5316\u7ade\u4e89\u5b9e\u9a8c\u5e76\u4e0d\u4e00\u81f4\uff0c\u4f46\u53ef\u4ee5\u901a\u8fc7\u78b1\u8f85\u52a9\u7684\u5185\u4eb2\u7535\u53d6\u4ee3\uff08BIES\uff09\u6765\u5408\u7406\u89e3\u91ca\u3002\u53cd\u5e94\u4ee5\u540c\u4f4d\u7d20\u6807\u8bb0\u7684D<\/span><span style=\"font-size: 14px;\"><sub>2<\/sub><\/span><span style=\"font-size: 18px;\">O\u4f5c\u4e3a\u5171\u6eb6\u5242\u5e76\u6ca1\u6709\u53d7\u5230\u4efb\u4f55\u5f71\u54cd\u3002\u4f5c\u8005\u8fd8\u8bbe\u8ba1\u4e86C-H\u952e\u6d3b\u5316\u7684\u52a8\u529b\u5b66\u7814\u7a76\uff0c\u5176\u52a8\u529b\u5b66\u540c\u4f4d\u7d20\u6548\u5e94\uff08KIE\uff09K<\/span><span style=\"font-size: 14px;\"><sub>H<\/sub><\/span><span style=\"font-size: 18px;\">\/K<\/span><span style=\"font-size: 14px;\"><sub>D<\/sub><\/span><span style=\"font-size: 18px;\">\u22481.1\u3002\u6c14\u76f8\u8272\u8c31\u5206\u6790\u8bc1\u5b9e\u4e86<span style=\"text-align: justify;font-size: 18px;\">H<\/span><span style=\"text-align: justify;font-size: 14px;\"><sub>2<\/sub><\/span>\u662f\u8be5\u53cd\u5e94\u552f\u4e00\u7684\u526f\u4ea7\u7269\u3002&nbsp;<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress2-1533786929.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe7. \u673a\u7406\u63a2\u7a76\u5b9e\u9a8c\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc<\/em>.<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u4f5c\u8005\u8fd8\u5229\u7528\u8d28\u8c31\u6cd5\u63a2\u7a76\u7535\u5316\u5b66C-H\u952e\u6d3b\u5316\u7684\u5173\u952e\u4e2d\u95f4\u4f53\uff08\u56fe8\uff09\u3002\u7535\u55b7\u96fe\u7535\u79bb\uff08ESI\uff09\u5206\u6790\u4e3a\u4e03\u5143\u94b4(III)\u6742\u73af\u7684\u5f62\u6210\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u652f\u6301\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress2-1533786929-1.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe8. \u8d28\u8c31\u5206\u6790\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u5bf9\u4e8e\u50ac\u5316\u5242\u7684\u7535\u5316\u5b66\u4f5c\u7528\u65b9\u5f0f\uff0c\u4f5c\u8005\u901a\u8fc7\u5faa\u73af\u4f0f\u5b89\u7814\u7a76\u63ed\u793a\u4e86Co(OAc)<\/span><span style=\"font-size: 14px;\"><sub>2<\/sub><\/span><span style=\"font-size: 18px;\">\u3001NaOPiv\u548c<strong>1a<\/strong>\u5728MeOH\u4e2d\u5f62\u6210\u94b4(\u2162)\u7269\u79cd\u7684\u8fc7\u7a0b\uff0c\u53d1\u73b0\u4e86\u65b0\u7684\u5bbd\u6c27\u5316\u6ce2\uff0c\u5176\u8d77\u59cb\u7535\u4f4d\u4e3a0.52 V<\/span><span style=\"font-size: 14px;\"><sub>SCE<\/sub><\/span><span style=\"font-size: 18px;\">\uff0c\u7535\u6d41\u6700\u5927\u503c\u4e3a0.99 <span style=\"text-align: justify;font-size: 18px;\">V<\/span><span style=\"text-align: justify;font-size: 14px;\"><sub>SCE<\/sub><\/span>\u3002\u4ee5\u4e0a\u7ed3\u679c\u8868\u660e\uff0c\u5e95\u7269\u5b58\u5728\u65f6\uff0c\u94b4(II)\u6c27\u5316\u4e3a\u94b4(III)\uff0c\u7535\u4f4d\u5927\u5927\u964d\u4f4e\u3002\u800c\u5728\u6df7\u5408\u4f53\u7cfb\u4e2d\u6dfb\u52a0\u7094<strong>7a<\/strong>\u5e76\u4e0d\u4f1a\u5bfc\u81f4\u53cd\u5e94\u660e\u663e\u7684\u6dec\u706d\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533786929.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe9. 100 mV\/s\u65f6MeOH\u4f53\u7cfb\u4e2d\u7684\u5faa\u73af\u4f0f\u5b89\u66f2\u7ebf\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u8ba1\u7b97\u7ed3\u679c\u8868\u660e\uff0c\u8be5\u53cd\u5e94\u7684\u533a\u57df\u9009\u62e9\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u7531\u5421\u5576\u7684\u6742\u82b3\u57fa\u4e0e\u82b3\u57fa\u4e59\u7094\u5355\u5143\u4e4b\u95f4\u7684\u6b21\u7ea7\u03c0-\u03c0\u76f8\u4e92\u4f5c\u7528\u51b3\u5b9a\u7684\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress0-1533786930.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe10, \u5173\u4e8e\u533a\u57df\u9009\u62e9\u6027\u7684\u8ba1\u7b97\u7ed3\u679c\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u6b64\u5916\uff0c\u7f3a\u7535\u5b50\u7684\u5421\u5576\u57fa\u548c\u5bcc\u7535\u5b50\u7684\u82b3\u57fa\u4e0e\u975e\u5bf9\u79f0\u7684\u7094\u53d1\u751fC-H\/N-H\u952e\u6d3b\u5316\u7684\u8ba1\u7b97\u7ed3\u679c\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u8fd9\u79cd\u03c0-\u03c0\u76f8\u4e92\u4f5c\u7528\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533786930.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe11. \u975e\u5bf9\u79f0\u7684\u7094<strong>2k<\/strong>\u8fc1\u79fb\u63d2\u5165\u65f6\u533a\u57df\u9009\u62e9\u6027\u7684\u8ba1\u7b97\u7ed3\u679c\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u4f5c\u8005\u5728\u7535\u55b7\u96fe\u8d28\u8c31\u5206\u6790\u4e2d\u5df2\u89c2\u5bdf\u5230\u8fc1\u79fb\u63d2\u5165\u5f97\u5230\u7684\u4e03\u5143\u94b4(III)\u6742\u73af<strong>9<\/strong>\uff08\u56fe12\uff09\u3002\u8be5\u7269\u79cd\u5728\u4e09\u91cd\u6001\u72b6\u6001\u4e0b\u53d1\u751f\u7b80\u5355\u7684\u8fd8\u539f\u6d88\u9664\uff0c\u800c\u6ca1\u6709\u53d1\u751f\u81ea\u65cb\u8f6c\u6362\uff0c\u7531\u6b64\u5f62\u6210\u94b4(I)\u7269\u79cd\uff0c\u4e3a\u9633\u6781\u6c27\u5316\u518d\u751f\u50ac\u5316\u6d3b\u6027\u7269\u79cd\u5960\u5b9a\u4e86\u57fa\u7840\u3002\u540c\u65f6\uff0c\u4f5c\u8005\u8fd8\u53d1\u73b0\u5f31\u8272\u6563\u76f8\u4e92\u4f5c\u7528\u80fd\u7a33\u5b9a\u4e34\u754c\u8fc7\u6e21\u6001\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress3-1533786930.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe12. \u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684[4+2]\u73af\u5316\u53cd\u5e94\u7684\u8ba1\u7b97\u7ed3\u679c\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u57fa\u4e8e\u4ee5\u4e0a\u5b9e\u9a8c\u548c\u8ba1\u7b97\u7ed3\u679c\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u53ef\u80fd\u7684\u53cd\u5e94\u673a\u7406\u3002\u7535\u5316\u5b66\u6c27\u5316\u5f62\u6210\u7684\u5177\u6709\u50ac\u5316\u6d3b\u6027\u7684\u94b4(III)\u7fa7\u9178\u76d0\u7269\u79cd<strong>10<\/strong>\u901a\u8fc7\u9633\u6781\u6c27\u5316\u542f\u52a8\u53cd\u5e94\uff0c\u968f\u540e\u901a\u8fc7\u7fa7\u9178\u916f\u8f85\u52a9\u7684C-H\u952e\u6d3b\u5316\u5f97\u5230\u4e2d\u95f4\u4f53<strong>11<\/strong>\uff0c\u8fc1\u79fb\u63d2\u5165\u4ea7\u751f\u4e03\u5143\u94b4(III)\u6742\u73af\u7269\u79cd<strong>9<\/strong>\u3002<strong>9<\/strong>\u8fd8\u539f\u6d88\u9664\u5f97\u5230\u9884\u671f\u7684\u4ea7\u7269<strong>3<\/strong>\uff0c\u5e76\u5f62\u6210\u94b4(I)\u7269\u79cd<strong>12<\/strong>\uff0c\u9633\u6781\u6c27\u5316\u518d\u751f\u50ac\u5316\u6d3b\u6027\u7684\u94b4(III)\u7fa7\u9178\u914d\u5408\u7269<strong>10<\/strong>\u3002\u6574\u4e2a\u8fc7\u7a0b\u672a\u4f7f\u7528\u6709\u6bd2\u548c\u6602\u8d35\u7684\u91d1\u5c5e\u4f5c\u4e3a\u5316\u5b66\u8ba1\u91cf\u7684\u6c27\u5316\u5242\uff0c\u751f\u6210\u7684<span style=\"text-align: justify;font-size: 18px;\">H<\/span><span style=\"text-align: justify;font-size: 14px;\"><sub>2<\/sub><\/span>\u662f\u8be5\u53cd\u5e94\u552f\u4e00\u7684\u526f\u4ea7\u7269\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress3-1533786930-1.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe13. \u53ef\u80fd\u7684\u50ac\u5316\u5faa\u73af\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">\u6700\u540e\uff0c\u4f5c\u8005\u8fd8\u5c1d\u8bd5\u4e86C-H\u952e\u6d3b\u5316\u53cd\u5e94\u4e2d\u7b2c\u4e00\u4f8b\u7535\u5316\u5b66\u6d88\u9664\u5bfc\u5411\u57fa\u56e2\u7684\u65b9\u6cd5\u3002\u4ed6\u4eec\u5728\u5ba4\u6e29\u6761\u4ef6\u4e0b\u901a\u8fc7\u7535\u5316\u5b66\u8fd8\u539f\u7684\u65b9\u5f0f\uff0c\u4ee5DMF\u4f5c\u4e3a\u6eb6\u5242\uff0c<em>n<\/em>-Bu<\/span><span style=\"font-size: 14px;\"><sub>4<\/sub><\/span><span style=\"font-size: 18px;\">NPF<\/span><span style=\"font-size: 14px;\"><sub>6<\/sub><\/span><span style=\"font-size: 18px;\">\u548cNaI\u7b49\u6469\u5c14\u6df7\u5408\u4f5c\u4e3a\u7535\u89e3\u8d28\uff0c23 \u2103\u4e0b\u4f7f\u7528\u9541\u9633\u6781\u5728\u50ac\u5316\u91cf\u7684SmI<\/span><span style=\"font-size: 14px;\"><sub>2<\/sub><\/span><span style=\"font-size: 18px;\">\u5b58\u5728\u4e0b\u5373\u53ef\u5f97\u5230\u76ee\u6807\u4ea7\u7269<strong>13cc<\/strong>\uff0c\u6536\u7387\u4e3a90%\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533786930.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 16px;color: rgb(136, 136, 136);\">\u56fe14. \u7535\u5316\u5b66\u8fd8\u539f\u7684\u65b9\u6cd5\u6d88\u9664\u9170\u80bc\u3002\u56fe\u7247\u6765\u6e90\uff1a<em>J. Am. Chem. Soc.<\/em><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\"><span style=\"color: rgb(33, 127, 188);\"><strong><span style=\"font-size: 18px;\">\u603b\u7ed3<\/span><\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><span style=\"font-size: 18px;\">Lutz Ackermann\u6559\u6388\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684[4+2]\u73af\u5316\u53cd\u5e94\uff0c\u5b9e\u73b0\u4e86\u7535\u5316\u5b66\u6c27\u5316\u7684C-H\/N-H\u952e\u6d3b\u5316\u3002\u8be5\u53cd\u5e94\u53ef\u4ee5\u5728\u6e29\u548c\u7684\u6761\u4ef6\u4e0b\u8fdb\u884c\uff0c\u539f\u6599\u548c\u50ac\u5316\u5242\u6765\u6e90\u4e30\u5bcc\uff0c\u5e76\u5177\u6709\u826f\u597d\u7684\u533a\u57df\u9009\u62e9\u6027\uff0c\u907f\u514d\u4e86\u8fc7\u6e21\u91d1\u5c5e\u6c27\u5316\u5242\u7684\u4f7f\u7528\uff0c\u4ea7\u751f\u7684<span style=\"text-align: justify;font-size: 18px;\">H<\/span><span style=\"text-align: justify;font-size: 14px;\"><sub>2<\/sub><\/span>\u662f\u552f\u4e00\u7684\u526f\u4ea7\u7269\u3002\u8be6\u7ec6\u7684\u673a\u7406\u7814\u7a76\u3001\u8d28\u8c31\u5206\u6790\u548cDFT\u8ba1\u7b97\u8868\u660e\u4ee5\u533a\u57df\u9009\u62e9\u6027\u7684\u65b9\u5f0f\u5f62\u6210\u5173\u952e\u7684\u4e03\u5143\u94b4(\u2162)\u6742\u73af\u7269\u79cd\u81f3\u5173\u91cd\u8981\u3002\u8be5\u65b9\u6cd5\u5bf9\u542b\u6c2e\u6742\u73af\u7684\u5408\u6210\u4ee5\u53ca\u836f\u7269\u7684\u540e\u671f\u884d\u751f\u5316\u5177\u6709\u975e\u5e38\u91cd\u8981\u7684\u5e94\u7528\u4ef7\u503c\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u539f\u6587\uff08\u626b\u63cf\u6216\u957f\u6309\u4e8c\u7ef4\u7801\uff0c\u8bc6\u522b\u540e\u76f4\u8fbe\u539f\u6587\u9875\u9762\uff09\uff1a<\/span><\/p>\n<p><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533786931.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">Electroremovable Traceless Hydrazides for Cobalt-Catalyzed Electro-Oxidative C\u2013H\/N\u2013H Activation with Internal Alkynes<\/span><\/p>\n<p><em><span style=\"font-size: 14px;\">J. Am. Chem. Soc<\/span><\/em><span style=\"font-size: 14px;\">., <strong>2018<\/strong>, <em>140<\/em>, 7913, DOI: 10.1021\/jacs.8b03521<\/span><\/p>\n<p><br  \/><\/p>\n<section style=\"white-space: normal;\">\n<section class=\"Powered-by-XIUMI V5\" >\n<section class=\"\">\n<section class=\"\">\n<p style=\"text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533786931.jpeg\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 25.6px;text-align: center;\"><img      style=\"font-size: 18px;background-color: rgb(255, 255, 255);line-height: 25.6px;width: 556px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress3-1533786931.png\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<section style=\"white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section class=\"\" style=\"height: 16px;box-sizing: border-box;\">\n<section style=\"height: 15.9961px;width: 24px;float: left;border-top: 6px solid rgb(9, 158, 206);border-left: 6px solid rgb(9, 158, 206);border-right-color: rgb(9, 158, 206);border-bottom-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<section style=\"height: 15.9961px;width: 24px;float: right;border-top: 6px solid rgb(9, 158, 206);border-right: 6px solid rgb(9, 158, 206);border-bottom-color: rgb(9, 158, 206);border-left-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<section style=\"display: inline-block;color: transparent;clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<section class=\"\" style=\"margin: -13px 3px;padding: 12px;border-width: 1px;border-style: solid;border-color: rgb(9, 158, 206);border-radius: 6px;word-wrap: break-word;box-sizing: border-box;\">\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 18px;\">\u672c\u6587\u7248\u6743\u5c5e\u4e8e<span style=\"color: rgb(9, 158, 206);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">X-MOL<\/strong><\/span>\uff08x-mol.com\uff09\uff0c\u672a\u7ecf\u8bb8\u53ef\u8c22\u7edd\u8f6c\u8f7d\uff01\u6b22\u8fce\u8bfb\u8005\u670b\u53cb\u4eec\u5206\u4eab\u5230\u670b\u53cb\u5708or\u5fae\u535a\uff01<\/span><\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"box-sizing: border-box;\"><span style=\"font-size: 18px;\"><span style=\"color: rgb(9, 158, 206);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u957f\u6309<\/strong><\/span>\u4e0b\u56fe<strong style=\"box-sizing: border-box;\">\u8bc6\u522b\u56fe\u4e2d\u4e8c\u7ef4\u7801<\/strong>\uff0c\u8f7b\u677e\u5173\u6ce8\u6211\u4eec\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"Powered-by-XIUMI V5\"  style=\"box-sizing: border-box;\">\n<p style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<\/section>\n<\/section>\n<section class=\"\" style=\"height: 16px;box-sizing: border-box;\">\n<section style=\"height: 15.9961px;width: 24px;float: left;border-bottom: 6px solid rgb(9, 158, 206);border-left: 6px solid rgb(9, 158, 206);border-top-color: rgb(9, 158, 206);border-right-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<section style=\"height: 15.9961px;width: 24px;float: right;border-bottom: 6px solid rgb(9, 158, 206);border-right: 6px solid rgb(9, 158, 206);border-top-color: rgb(9, 158, 206);border-left-color: rgb(9, 158, 206);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"white-space: normal;\">\n<section >\n<section>\n<section>\n<section>\n<section >\n<section>\n<section>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;line-height: 25.6px;font-size: 18.018px;max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u70b9\u51fb\u201c<span style=\"max-width: 100%;color: rgb(0, 122, 170);\">\u9605\u8bfb\u539f\u6587<\/span>\u201d\uff0c\u67e5\u770b&nbsp;<strong>\u5316\u5b66 \u2022 \u6750\u6599&nbsp;<\/strong>\u9886\u57df<span style=\"max-width: 100%;background-color: rgb(255, 218, 81);\">\u6240\u6709\u6536\u5f55\u671f\u520a<\/span><\/span><\/p>\n<p style=\"white-space: normal;line-height: 25.6px;font-size: 18.018px;max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><img     style=\"color: rgb(0, 0, 0);font-size: 14px;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress4-1533786931.gif\" alt=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\" title=\"\u94b4\u50ac\u5316\u5185\u7094\u53c2\u4e0e\u7684\u7535\u5316\u5b66\u6c27\u5316C-H\/N-H\u952e\u6d3b\u5316\"  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         X\u4e00MOL\u8d44\u8baf                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u200d\u200d\u200d \u7535\u50ac\u5316\u53cd\u5e94\u53ef\u4ee5\u907f\u514d\u5728\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u4f7f\u7528\u6210\u672c\u8f83\u9ad8\u7684\u5316\u5b66\u8bd5\u5242\uff0c\u51cf\u5c11\u4e0d\u5fc5\u8981\u7684\u526f\u4ea7\u7269\u4ea7\u751f\u3002\u8fd1\u5e74\u6765\uff0c\u8fc7\u6e21\u91d1\u5c5e [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":28417,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/28416"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=28416"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/28416\/revisions"}],"predecessor-version":[{"id":28442,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/28416\/revisions\/28442"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/28417"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=28416"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=28416"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=28416"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}