{"id":28573,"date":"2018-08-06T01:00:00","date_gmt":"2018-08-09T03:56:15","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e3%80%90%e5%8c%96%e5%ad%a6%e7%94%9f%e7%89%a9%e5%ad%a6%e3%80%91%e5%8c%96%e5%ad%a6%e8%b0%83%e6%8e%a7%e8%8d%a7%e5%85%89%e8%9b%8b%e7%99%bd%e7%9a%84%e8%8d%a7%e5%85%89%e5%9f%ba%e5%9b%a2%e7%94%a8%e4%ba%8e\/"},"modified":"2018-08-09T11:56:17","modified_gmt":"2018-08-09T03:56:17","slug":"%e3%80%90%e5%8c%96%e5%ad%a6%e7%94%9f%e7%89%a9%e5%ad%a6%e3%80%91%e5%8c%96%e5%ad%a6%e8%b0%83%e6%8e%a7%e8%8d%a7%e5%85%89%e8%9b%8b%e7%99%bd%e7%9a%84%e8%8d%a7%e5%85%89%e5%9f%ba%e5%9b%a2%e7%94%a8%e4%ba%8e","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/28573\/","title":{"rendered":"\u3010\u5316\u5b66\u751f\u7269\u5b66\u3011\u5316\u5b66\u8c03\u63a7\u8367\u5149\u86cb\u767d\u7684\u8367\u5149\u57fa\u56e2\u7528\u4e8e\u63a2\u6d4b\u7ec6\u80de\u5185\u86cb\u767d\u8d28\u7684\u805a\u96c6"},"content":{"rendered":"
\n

\u200d\u200d<\/span>\u200d\"\u3010\u5316\u5b66\u751f\u7269\u5b66\u3011\u5316\u5b66\u8c03\u63a7\u8367\u5149\u86cb\u767d\u7684\u8367\u5149\u57fa\u56e2\u7528\u4e8e\u63a2\u6d4b\u7ec6\u80de\u5185\u86cb\u767d\u8d28\u7684\u805a\u96c6\"<\/span><\/a><\/span><\/a><\/p>\n


<\/p>\n

\u86cb\u767d\u8d28\u7684\u9519\u8bef\u6298\u53e0\u548c\u805a\u96c6\u4f1a\u5bfc\u81f4\u591a\u79cd\u4eba\u7c7b\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u5982\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u3001\u5e15\u91d1\u68ee\u7efc\u5408\u5f81\u3001\u6e10\u51bb\u4eba\u75c7\u7b49\u3002\u5728\u6d3b\u4f53\u7ec6\u80de\u5185\u6709\u6548\u5730\u8bc6\u522b\u86cb\u767d\u8d28\u7684\u805a\u96c6\u8fc7\u7a0b\uff0c\u5bf9\u7814\u7a76\u75be\u75c5\u7684\u53d1\u75c5\u673a\u7406\u548c\u7b5b\u9009\u836f\u7269\u5206\u5b50\u90fd\u6709\u7740\u79ef\u6781\u7684\u610f\u4e49\u3002\u7136\u800c\u86cb\u767d\u8d28\u7684\u9519\u8bef\u6298\u53e0\u4e0e\u805a\u96c6\u662f\u4e00\u4e2a\u590d\u6742\u7684\u7269\u7406\u5316\u5b66\u53d8\u5316\u8fc7\u7a0b\u3002\u5176\u4e2d\u5305\u542b\u4e86\u7531\u4e0d\u540c\u79cd\u86cb\u767d\u8d28\u6784\u6210\u7684\u591a\u79cd\u6298\u53e0\u72b6\u6001\u3002\u56e0\u6b64\uff0c\u5982\u4f55\u5b9e\u73b0\u5728\u7ec6\u80de\u5185\u89c2\u6d4b\u86cb\u767d\u8d28\u7684\u805a\u96c6\u8fc7\u7a0b\uff0c\u4e00\u76f4\u662f\u9886\u57df\u5185\u7684\u4e00\u4e2a\u6280\u672f\u96be\u9898\u3002<\/span><\/p>\n


<\/p>\n

\u8367\u5149\u86cb\u767d\u4e00\u76f4\u4ee5\u6765\u88ab\u5e7f\u6cdb\u5730\u7528\u4e8e\u751f\u547d\u79d1\u5b66\u9886\u57df\u3002\u5176\u4e2d\u4e00\u9879\u91cd\u8981\u7684\u5e94\u7528\u662f\u5728\u6d3b\u4f53\u7ec6\u80de\u5185\u9488\u5bf9\u76ee\u6807\u86cb\u767d\u8d28\u7684\u6210\u50cf\u4e0e\u793a\u8e2a\u3002\u5176\u4e2d\u7eff\u8272\u8367\u5149\u86cb\u767d\u662f\u901a\u8fc7\u5176\u8367\u5149\u57fa\u56e2<\/span>4-hydroxybenzylidene-imidazolinone\uff08HBI\uff09<\/span>\u53d1\u51fa\u8367\u5149\u3002\u7136\u800c\u8fd9\u7c7b\u8367\u5149\u5206\u5b50\u53ea\u6709\u9501\u5728\u8367\u5149\u86cb\u767d\u7684\u5185\u90e8\u624d\u4f1a\u53d1\u51fa\u8367\u5149\u3002\u4e3b\u8981\u539f\u56e0\u662f\u5f53\u8fd9\u7c7b\u5206\u5b50\u5728\u6fc0\u53d1\u6001\u81ea\u7531\u65cb\u8f6c\u65f6\uff0c\u5176\u975e\u8f90\u5c04\u8870\u53d8\u901a\u9053\u5360\u636e\u4e3b\u5bfc\uff0c\u56e0\u6b64\u4eba\u5de5\u5408\u6210\u7684\u7c7b\u4f3c\u7269\u901a\u5e38\u8367\u5149\u6548\u7387\u5f88\u4f4e\u3002\u7136\u800c\u901a\u8fc7\u7a7a\u95f4\u4f4d\u963b\u6548\u5e94\u6291\u5236\u5176\u81ea\u7531\u65cb\u8f6c\uff0c\u53ef\u4ee5\u6709\u6548\u7684\u589e\u5f3a\u8367\u5149\u91cf\u5b50\u6548\u7387\u3002\u57fa\u4e8e\u4e0a\u8ff0\u7279\u6027\uff0c\u6b64\u7c7b\u5206\u5b50\u88ab\u5e7f\u6cdb\u7684\u7528\u4e8e\u7ec6\u80de\u5185RNA\u548cDNA\u7684\u63a2\u6d4b\u4e0e\u8bc6\u522b\u3002<\/span><\/p>\n

\"\u3010\u5316\u5b66\u751f\u7269\u5b66\u3011\u5316\u5b66\u8c03\u63a7\u8367\u5149\u86cb\u767d\u7684\u8367\u5149\u57fa\u56e2\u7528\u4e8e\u63a2\u6d4b\u7ec6\u80de\u5185\u86cb\u767d\u8d28\u7684\u805a\u96c6\"<\/p>\n


<\/p>\n

\u7f8e\u56fd\u5bbe\u5dde\u5dde\u7acb\u5927\u5b66\u5f20\u946b<\/span><\/strong>\u6559\u6388\u56e2\u961f\u9996\u6b21\u5c55\u793a\u8367\u5149\u86cb\u767d\u5185\u7684\u8367\u5149\u57fa\u56e2\u53ef\u7528\u4e8e\u8bc6\u522b\u86cb\u767d\u8d28\u7684\u805a\u96c6\u6001<\/strong>\u3002\u901a\u8fc7\u5316\u5b66\u8c03\u63a7\u8367\u5149\u86cb\u767d\u7684\u8367\u5149\u57fa\u56e2\uff08HBI\uff09\uff0c\u5728\u6d3b\u4f53\u7ec6\u80de\u5185\u6210\u529f\u63a2\u6d4b\u591a\u79cd\u76ee\u6807\u86cb\u767d\u8d28\u805a\u96c6\u6001\u7684\u63a2\u6d4b\u3002\u86cb\u767d\u8d28\u7684\u9519\u8bef\u6298\u53e0\u548c\u805a\u96c6\u4f1a\u9020\u6210\u86cb\u767d\u5c40\u90e8\u5fae\u73af\u5883\u7684\u53d8\u5316\uff0c\u5305\u62ec\u6d41\u52a8\u6027\u4e0b\u964d\u3001\u7a7a\u95f4\u4f4d\u963b\u7684\u589e\u5927\u548c\u521a\u6027\u7684\u589e\u5f3a\u3002\u6587\u7ae0\u9996\u5148\u5408\u6210\u591a\u79cdHBI\u5206\u5b50\u7684\u884d\u751f\u7269\uff0c\u603b\u7ed3\u4e86\u5316\u5b66\u4e0a\u5982\u4f55\u8c03\u63a7\u5206\u5b50\u8367\u5149\u6027\u8d28\u7684\u5316\u5b66\u89c4\u5f8b\uff0c\u5b9e\u73b0\u5bf9\u4e0a\u8ff0\u7269\u7406\u73af\u5883\u53d8\u5316\u66f4\u52a0\u654f\u611f\u7684\u63a2\u6d4b\u3002\u7f8e\u56fd\u534e\u76db\u987f\u5927\u5b66\u674e\u6653\u677e<\/strong>\u6559\u6388\u56e2\u961f\u9488\u5bf9\u6b64\u7c7b\u5206\u5b50\u7684\u7406\u8bba\u8ba1\u7b97\u5de5\u4f5c\u66f4\u597d\u7684\u9610\u91ca\u4e86\u5206\u5b50\u53d1\u5149\u673a\u7406\u3002\u5f53\u86cb\u767d\u8d28\u53d1\u751f\u9519\u8bef\u6298\u53e0\u5e76\u805a\u96c6\u65f6\uff0c\u8367\u5149\u5206\u5b50\u4e0e\u805a\u96c6\u6001\u7684\u86cb\u767d\u8d28\u4e4b\u95f4\u53d1\u751f\u76f8\u4e92\u4f5c\u7528\uff0c\u6291\u5236\u4e86\u975e\u8f90\u5c04\u8870\u53d8\u901a\u9053\uff0c\u4f7f\u5176\u8367\u5149\u91cf\u5b50\u6548\u7387\u5927\u5e45\u63d0\u5347\uff080.026\u52300.22\uff09\u3002\u6587\u7ae0\u8fdb\u4e00\u6b65\u5728\u591a\u4e2a\u81f4\u75c5\u86cb\u767d\u4f53\u7cfb\u4e2d\uff0c\u5982\u03b1-synuclein\uff08\u5e15\u91d1\u68ee\u75c7\uff09\u3001\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176\uff08\u6e10\u51bb\u4eba\u75c7\uff09\u548cpolyQ\uff08\u4ea8\u5ef7\u987f\u821e\u8e48\u75c7\uff09\uff0c\u5206\u5e03\u5c55\u793a\u4e86\u6b64\u7c7b\u5206\u5b50\u5bf9\u86cb\u767d\u8d28\u805a\u96c6\u72b6\u6001\u8367\u5149\u6fc0\u6d3b\u7c7b\u578b\u7684\u8bc6\u522b\u3002<\/span><\/p>\n


<\/p>\n

\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u9886\u57df\u6700\u65b0\u7684\u5047\u8bf4\u8ba4\u4e3a\u86cb\u767d\u8d28\u53ef\u6eb6\u805a\u96c6\u6001\u7684\u7ec6\u80de\u6bd2\u6027\u6700\u5f3a\u3002\u4e0d\u540c\u4e8e\u4f20\u7edf\u65b9\u6cd5\uff0c\u8fd9\u9879\u5de5\u4f5c\u6240\u53d1\u5c55\u7684\u65b0\u578b\u8367\u5149\u63a2\u9488\u53ef\u4ee5\u6709\u6548\u7684\u8bc6\u522b\u65e9\u671f\u53ef\u6eb6\u805a\u96c6\u6001\u7684\u86cb\u767d\u8d28\u3002\u540c\u65f6\uff0c\u901a\u8fc7\u4e0e\u5546\u4e1a\u5316\u7684HaloTag\u4f53\u7cfb\u8054\u7528\uff0c\u53ef\u4ee5\u5c06\u6240\u53d1\u5c55\u7684\u65b0\u578b\u8367\u5149\u5206\u5b50\u7528\u4e8e\u4efb\u610f\u76ee\u6807\u86cb\u767d\u8d28\u805a\u96c6\u6001\u7684\u63a2\u6d4b\u3002\u6587\u672b\uff0c\u4f5c\u8005\u63d0\u5230\u672a\u6765\u7684\u5de5\u4f5c\u53ef\u4ee5\u8fdb\u4e00\u6b65\u62d3\u5c55\u5316\u5b66\u7a7a\u95f4\uff0c\u4f18\u5316\u73af\u5883\u654f\u611f\u7c7b\u522b\u7684\u8367\u5149\u5206\u5b50\u5b9e\u73b0\u5bf9\u86cb\u767d\u8d28\u5404\u79cd\u6298\u53e0\u72b6\u6001\u7684\u7cbe\u51c6\u8bc6\u522b\u3002\u8fd9\u4e00\u7814\u7a76\u6210\u679c\u8fd1\u671f\u53d1\u8868\u5728<\/span>J. Am. Chem. Soc.<\/strong><\/em><\/span> \u4e0a\uff0c\u6587\u7ae0\u7684\u7b2c\u4e00\u4f5c\u8005\u662f\u7f8e\u56fd\u5bbe\u5dde\u5dde\u7acb\u5927\u5b66\u5218\u5b87<\/strong>\u535a\u58eb\uff0c\u901a\u8baf\u4f5c\u8005\u662f\u5f20\u946b<\/strong>\u6559\u6388\u3002<\/span><\/p>\n


<\/p>\n

\u8be5\u8bba\u6587\u4f5c\u8005\u4e3a\uff1a<\/span><\/strong>Yu Liu, Charles H. Wolstenholme, Gregory C. Carter, Hongbin Liu, Hang Hu, Leeann S. Grainger, Kun Miao, Matthew Fares, Conner A. Hoelzel, Hemant P. Yennawar, Gang Ning, Manyu Du, Lu Bai, Xiaosong Li, Xin Zhang<\/span><\/p>\n

\u539f\u6587\uff08\u626b\u63cf\u6216\u957f\u6309\u4e8c\u7ef4\u7801\uff0c\u8bc6\u522b\u540e\u76f4\u8fbe\u539f\u6587\u9875\u9762\uff09\uff1a<\/span><\/p>\n

\"\u3010\u5316\u5b66\u751f\u7269\u5b66\u3011\u5316\u5b66\u8c03\u63a7\u8367\u5149\u86cb\u767d\u7684\u8367\u5149\u57fa\u56e2\u7528\u4e8e\u63a2\u6d4b\u7ec6\u80de\u5185\u86cb\u767d\u8d28\u7684\u805a\u96c6\"<\/p>\n

Modulation of Fluorescent Protein Chromophores To Detect Protein Aggregation with Turn-On Fluorescence<\/span><\/p>\n

J. Am. Chem. Soc.<\/span><\/em>, 2018<\/strong>, 140<\/em>, 7381\u20137384, DOI: 10.1021\/jacs.8b02176<\/span><\/p>\n


<\/p>\n

\u5f20\u946b\u6559\u6388\u7b80\u4ecb<\/span><\/strong><\/p>\n


<\/p>\n

\u5f20\u946b\uff0c\u7f8e\u56fd\u5bbe\u5dde\u5dde\u7acb\u5927\u5b66\u5316\u5b66\u7cfb\u548c\u751f\u7269\u5316\u5b66\u4e0e\u5206\u5b50\u751f\u7269\u5b66\u7cfb\u52a9\u7406\u6559\u6388\u30022001\u5e74\u672c\u79d1\u6bd5\u4e1a\u4e8e\u4e2d\u56fd\u79d1\u5b66\u6280\u672f\u5927\u5b66\uff1b 2004\u5e74\u7855\u58eb\u6bd5\u4e1a\u4e8e\u4e2d\u79d1\u9662\u5927\u8fde\u5316\u7269\u6240\uff1b2010\u5e74\u83b7\u52a0\u5dde\u7406\u5de5\u5b66\u9662\u535a\u58eb\u5b66\u4f4d\uff0c\u968f\u540e\u8fdb\u5165\u7f8e\u56fdScripps\u7814\u7a76\u6240\u505a\u535a\u58eb\u540e\u7814\u7a76\u3002<\/span><\/p>\n


<\/p>\n

\u7814\u7a76\u9886\u57df\u662f\u86cb\u767d\u8d28\u6298\u53e0\u7684\u5316\u5b66\u751f\u7269\u5b66\u7814\u7a76\u3002\u4ed6\u7684\u591a\u9879\u7814\u7a76\u6210\u679c\u53d1\u8868\u5728Science\u3001PNAS\u3001JACS <\/em>\u548cAngewandte Chemie <\/em>\u7b49\u671f\u520a\u4e0a\u3002\u5f20\u946b\u83b7\u5f97\u7684\u4e3b\u8981\u5956\u9879\u5305\u62ec2011\u83b7Helen Hay Whitney Fellowship Award\uff1b2012\u5e74\u83b7\u201c\u7f8e\u56fd\u5316\u5b66\u4f1a\u8bfa\u8d1d\u5c14\u7b7e\u540d\u5956\u201d\uff08The American Chemical Society Nobel Laureate Signature Award\uff09\uff1b2014\u83b7\u201cBurroughs-Wellcome\u57fa\u91d1\u4f1a\u4ea4\u53c9\u79d1\u5b66\u804c\u4e1a\u5956\u201d\uff08The Burroughs-Wellcome Fund Career Award at the Scientific Interface\uff09\uff1b2015\u83b7\u201cLloyd and Dottie Huck\u65e9\u671f\u804c\u4e1a\u5956\u201d\uff08The Lloyd and Dottie Huck Early Career Award\uff09\uff1b2018\u5e74\u83b7\u7f8e\u56fd\u65af\u9686\u7814\u7a76\u5956\uff08The Sloan Research Fellowship\uff09\u3002<\/span><\/p>\n


<\/p>\n

http:\/\/www.x-mol.com\/university\/faculty\/49777<\/span><\/p>\n


<\/p>\n

\n
\n
\n
\n

\"\u3010\u5316\u5b66\u751f\u7269\u5b66\u3011\u5316\u5b66\u8c03\u63a7\u8367\u5149\u86cb\u767d\u7684\u8367\u5149\u57fa\u56e2\u7528\u4e8e\u63a2\u6d4b\u7ec6\u80de\u5185\u86cb\u767d\u8d28\u7684\u805a\u96c6\"<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\"\u3010\u5316\u5b66\u751f\u7269\u5b66\u3011\u5316\u5b66\u8c03\u63a7\u8367\u5149\u86cb\u767d\u7684\u8367\u5149\u57fa\u56e2\u7528\u4e8e\u63a2\u6d4b\u7ec6\u80de\u5185\u86cb\u767d\u8d28\u7684\u805a\u96c6\"<\/p>\n

\n
\n
\n
\n
<\/section>\n
<\/section>\n
<\/section>\n<\/section>\n
\n
\n
\n
\n

\u672c\u6587\u7248\u6743\u5c5e\u4e8eX-MOL<\/strong><\/span>\uff08x-mol.com\uff09\uff0c\u672a\u7ecf\u8bb8\u53ef\u8c22\u7edd\u8f6c\u8f7d\uff01\u6b22\u8fce\u8bfb\u8005\u670b\u53cb\u4eec\u5206\u4eab\u5230\u670b\u53cb\u5708or\u5fae\u535a\uff01<\/span><\/p>\n


<\/p>\n

\u957f\u6309<\/strong><\/span>\u4e0b\u56fe\u8bc6\u522b\u56fe\u4e2d\u4e8c\u7ef4\u7801<\/strong>\uff0c\u8f7b\u677e\u5173\u6ce8\u6211\u4eec\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

\n<\/section>\n<\/section>\n

\n
<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587<\/span>\u201d\uff0c\u67e5\u770b \u5316\u5b66 \u2022 \u6750\u6599 <\/strong>\u9886\u57df\u6240\u6709\u6536\u5f55\u671f\u520a<\/span><\/span><\/p>\n

<\/span>\"\u3010\u5316\u5b66\u751f\u7269\u5b66\u3011\u5316\u5b66\u8c03\u63a7\u8367\u5149\u86cb\u767d\u7684\u8367\u5149\u57fa\u56e2\u7528\u4e8e\u63a2\u6d4b\u7ec6\u80de\u5185\u86cb\u767d\u8d28\u7684\u805a\u96c6\"<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a X\u4e00MOL\u8d44\u8baf <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u200d\u200d\u200d \u86cb\u767d\u8d28\u7684\u9519\u8bef\u6298\u53e0\u548c\u805a\u96c6\u4f1a\u5bfc\u81f4\u591a\u79cd\u4eba\u7c7b\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u5982\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u3001\u5e15\u91d1\u68ee\u7efc\u5408\u5f81\u3001\u6e10\u51bb\u4eba\u75c7\u7b49\u3002\u5728\u6d3b\u4f53\u7ec6 […]<\/p>\n","protected":false},"author":1,"featured_media":28574,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/28573"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=28573"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/28573\/revisions"}],"predecessor-version":[{"id":28585,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/28573\/revisions\/28585"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/28574"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=28573"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=28573"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=28573"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}