{"id":29087,"date":"2018-07-31T01:00:00","date_gmt":"2018-08-09T03:59:05","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e3%80%90%e6%9c%89%e6%9c%ba%e3%80%91%e7%bb%8f%e7%94%b1%e9%ab%98%e9%80%9f33-sigmatropic%e9%87%8d%e6%8e%92%e7%9a%84%e8%8a%b3%e7%83%83%e6%b0%b0%e7%83%b7%e5%9f%ba%e5%8c%96%e5%8f%8d%e5%ba%94\/"},"modified":"2018-08-09T11:59:09","modified_gmt":"2018-08-09T03:59:09","slug":"%e3%80%90%e6%9c%89%e6%9c%ba%e3%80%91%e7%bb%8f%e7%94%b1%e9%ab%98%e9%80%9f33-sigmatropic%e9%87%8d%e6%8e%92%e7%9a%84%e8%8a%b3%e7%83%83%e6%b0%b0%e7%83%b7%e5%9f%ba%e5%8c%96%e5%8f%8d%e5%ba%94","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/29087\/","title":{"rendered":"\u3010\u6709\u673a\u3011\u7ecf\u7531\u9ad8\u901f[3,3]- Sigmatropic\u91cd\u6392\u7684\u82b3\u70c3\u6c30\u70f7\u57fa\u5316\u53cd\u5e94"},"content":{"rendered":"
\n

\u200d\u200d<\/span>\u200d\"\u3010\u6709\u673a\u3011\u7ecf\u7531\u9ad8\u901f[3,3]-<\/span><\/a><\/span><\/a><\/p>\n


<\/p>\n

\u03b1-\u82b3\u57fa\u8148\u53ca\u5176\u884d\u7269\u5728\u836f\u7269\u548c\u5929\u7136\u4ea7\u7269\u4e2d\u6709\u7740\u5e7f\u6cdb\u5206\u5e03\u3002\u901a\u8fc7\u7b80\u5355\u7684\u6c34\u89e3\u6216\u8fd8\u539f\uff0c\u03b1-\u82b3\u57fa\u8148\u53ef\u4ee5\u8f6c\u5316\u4e3a\u03b1-\u82b3\u57fa\u9170\u80fa\u3001\u03b1-\u82b3\u57fa\u7fa7\u9178\u3001\u03b1-\u82b3\u57fa\u916e\u3001\u03b2-\u82b3\u57fa\u4f2f\u80fa\u7b49\u91cd\u8981\u7684\u6709\u673a\u5408\u6210\u5b50\u3002\u56e0\u6b64\uff0c\u03b1-\u82b3\u57fa\u8148\u7684\u5236\u5907\u6210\u4e3a\u5408\u6210\u5316\u5b66\u7684\u91cd\u8981\u7814\u7a76\u65b9\u5411\u3002<\/span><\/p>\n

\"\u3010\u6709\u673a\u3011\u7ecf\u7531\u9ad8\u901f[3,3]-<\/p>\n


<\/span><\/p>\n

1991\u52301996\u5e74\u671f\u95f4\uff0cWalters\u53ca\u5176\u5408\u4f5c\u8005\u53d1\u73b0\uff1a\u70ef\u4e19\u57fa\u4e59\u70ef\u57fa\u80fa\u5728\u9ad8\u6e29\u4e0b\u53ef\u53d1\u751f\u91cd\u6392\uff08eq 1\uff09\uff0c\u80fd\u5792\u8f83\u9ad8\uff0834.6 kcal\/mol\uff09\uff1b\u800c\u70ef\u4e19\u57fa\u70ef\u916e\u4e9a\u80fa\u5219\u53ef\u4ee5\u5728\u5ba4\u6e29\u4e0b\u53d1\u751f\u91cd\u6392\uff08eq 2\uff09\uff0c\u80fd\u5792\u8f83\u4f4e\uff0817.7 kcal\/mol\uff09\uff08J. Am. Chem. Soc<\/em>., 1994<\/strong>, 116<\/em>, 11618\uff09\u3002\u4f5c\u8005\u63a8\u65ad\u70ef\u916e\u4e9a\u80fa\u7ed3\u6784\u7684\u5f20\u529b\u5728\u91cd\u6392\u4e2d\u5f97\u4ee5\u91ca\u653e\u662f\u8be5[3,3]-sigmatropic\u91cd\u6392\u80fd\u591f\u8f83\u5bb9\u6613\u53d1\u751f\u7684\u539f\u56e0\u3002\u4f46\u968f\u540e30\u5e74\u91cc\uff0c\u6709\u5173\u5f20\u529b\u91ca\u653e\u4fc3\u8fdb\u91cd\u6392\u7684\u7814\u7a76\u9c9c\u6709\u62a5\u9053\u3002\u5176\u539f\u56e0\u53ef\u80fd\u662f\u7f3a\u5c11\u6709\u6548\u6784\u5efa\u542b\u6709\u70ef\u916e\u4e9a\u80fa\u7ed3\u6784\u7684\u91cd\u6392\u524d\u4f53\u7684\u65b9\u6cd5\u3002\u8fd1\u671f\uff0c\u6d59\u6c5f\u5e08\u8303\u5927\u5b66\u5f6d\u52c3<\/strong>\u8bfe\u9898\u7ec4\u610f\u5916\u53d1\u73b0\u4e8c\u82b3\u57fa\u4e9a\u781c\u4e0e\u70f7\u57fa\u8148\u5728\u4eb2\u7535\u8bd5\u5242\u548c\u6709\u673a\u78b1\u7684\u4f5c\u7528\u4e0b\uff0c\u53ef\u4ee5\u53d1\u751f\u81ea\u6c27\u5316\u8fd8\u539f\u5076\u8054\u53cd\u5e94\uff0c\u4ece\u800c\u5b9e\u73b0\u4e86\u03b1-\u82b3\u57fa\u8148\u7684\u5236\u5907\uff08J. Am. Chem. Soc<\/em>., 2017<\/strong>, 139<\/em>, 4211.\uff09\u673a\u7406\u7814\u7a76\u8868\u660e\uff0c\u8be5\u53cd\u5e94\u7ecf\u5386\u4e86\u4e2d\u95f4\u4f53\u70ef\u916e\u4e9a\u80fa\u786b\u9393\u76d0IM1<\/strong>\u7684[3,3]-sigmatropic\u91cd\u6392\u8fc7\u7a0b\uff08eq 3\uff09\uff0c\u4e14\u8be5\u91cd\u6392\u8fc7\u7a0b\u80fd\u5792\u8f83\u4f4e\uff08\u4ec511.0 kcal\/mol\uff09\u3002\u4e0d\u96be\u770b\u51fa\uff0c\u8be5\u53cd\u5e94\u6b63\u662f\u5f20\u529b\u91ca\u653e\u4fc3\u8fdb\u7684\u91cd\u6392\u53cd\u5e94\u3002\u968f\u540e\uff0c\u8be5\u8bfe\u9898\u7ec4\u5e94\u7528\u540c\u6837\u7684\u7b56\u7565\uff0c\u901a\u8fc7\u5f15\u5165\u03b1-Sn\u53d6\u4ee3\u7684\u70f7\u57fa\u8148\uff0c\u76f4\u63a5\u6784\u5efa\u91cd\u6392\u524d\u4f53\uff08\u70ef\u916e\u4e9a\u80fa\u786b\u9393\u76d0IM1<\/strong>\uff09\uff0c\u5b9e\u73b0\u4e86\u4e0d\u540c\u603b\u7c7b\u82b3\u57fa\u4e9a\u781c\u7684\u6c30\u70f7\u57fa\u5316\u53cd\u5e94\uff08Org. Chem. Front.<\/em>, 2018<\/strong>, 5<\/em>, 1756. Inside front cover\uff09\u3002<\/span><\/p>\n


<\/p>\n

\u57fa\u4e8e\u4e0a\u8ff0\u7814\u7a76\uff0c\u8be5\u8bfe\u9898\u7ec4\u5c06\u6ce8\u610f\u529b\u8f6c\u79fb\u5230\u82b3\u57fa\u9ad8\u4ef7\u7898<\/strong>\u9886\u57df\u3002\u4e0d\u96be\u8bbe\u60f3\uff0c\u5c06\u6c30\u70f7\u57fa\u4eb2\u6838\u8bd5\u5242\u5f15\u5165\u5230\u5177\u6709\u4eb2\u7535\u6027\u7684\u82b3\u57fa\u9ad8\u4ef7\u7898\uff0c\u5c06\u6709\u53ef\u80fd\u6784\u5efa\u540c\u6837\u5177\u6709\u5f20\u529b\u7684\u70ef\u916e\u4e9a\u80fa\u82b3\u57fa\u7898\u4e2d\u95f4\u4f53IM2<\/strong>\uff08eq 4\uff09\u3002\u901a\u8fc7\u5f20\u529b\u91ca\u653e\uff0cIM2<\/strong>\u91cd\u6392\u8f6c\u5316\u4e3a\u90bb\u7898\u03b1-\u82b3\u57fa\u8148\uff08eq 4\uff09\u3002\u57fa\u4e8e\u8fd9\u4e00\u8bbe\u60f3\uff0c\u8be5\u8bfe\u9898\u7ec4\u8fd1\u671f\u53d1\u5c55\u4e86\u82b3\u57fa\u9ad8\u4ef7\u7898\u90bb\u4f4d\u6c30\u70f7\u57fa\u5316\u53cd\u5e94<\/strong>\uff08Angew. Chem. Int. Ed.<\/em>, 2018<\/strong>, 57<\/em>, 9078.\uff09\u6d59\u6c5f\u5e08\u8303\u5927\u5b66\u7855\u58eb\u7814\u7a76\u751f\u7530\u4fca\u83d8<\/strong>\u4e3a\u8be5\u8bba\u6587\u7b2c\u4e00\u4f5c\u8005\uff0c\u8bfe\u9898\u7ec4\u9ec4\u946b<\/strong>\u535a\u58eb\u548c\u4e2d\u56fd\u79d1\u5b66\u9662\u5927\u5b66\u6c6a\u5fd7\u7965<\/strong>\u7814\u7a76\u5458\u4e3a\u8be5\u8bba\u6587\u5171\u540c\u901a\u8baf\u4f5c\u8005\u3002<\/span><\/p>\n

\"\u3010\u6709\u673a\u3011\u7ecf\u7531\u9ad8\u901f[3,3]-<\/p>\n


<\/p>\n

\u7814\u7a76\u4e4b\u521d\uff0c\u8bfe\u9898\u7ec4\u8003\u5bdf\u4e86\u4e0d\u540c\u79cd\u7c7b\u6c30\u70f7\u57fa\u4eb2\u6838\u8bd5\u5242\uff0c\u60ca\u559c\u5730\u53d1\u73b0\u03b1-Sn\u53d6\u4ee3\u7684\u70f7\u57fa\u8148\u80fd\u591f\u5b9e\u73b0\u671f\u5f85\u7684\u53cd\u5e94\u3002\u8fdb\u4e00\u6b65\u6761\u4ef6\u4f18\u5316\uff0c\u53d1\u73b0\u8be5\u53cd\u5e94\u80fd\u591f\u5728\u60ca\u4eba\u7684\u4f4e\u6e29\u4e0b\uff08-100 \u00b0C\uff09\u3001\u6781\u77ed\u65f6\u95f4\u5185\u5b8c\u6210\uff0810 s\uff09\u3002\u8be5\u53cd\u5e94\u662f\u7b2c\u4e00\u4f8b\u80fd\u591f\u5728\u5982\u6b64\u4f4e\u6e29\u4e0b\u3001\u77ed\u65f6\u95f4\u5185\u5b8c\u6210\u82b3\u70c3\u6c30\u70f7\u57fa\u5316\u7684\u53cd\u5e94\u3002<\/span><\/p>\n

\"\u3010\u6709\u673a\u3011\u7ecf\u7531\u9ad8\u901f[3,3]-<\/p>\n


<\/p>\n

\u5728\u6700\u4f18\u6761\u4ef6\u4e0b\uff0c\u53cd\u5e94\u5177\u6709\u4f18\u5f02\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\u3002\u5bb9\u6613\u88ab\u82b3\u57fa\u9ad8\u4ef7\u7898\u6c27\u5316\u7684\u5b98\u80fd\u56e2\uff08\u5bcc\u7535\u5b50\u70ef\u70c3\u3001\u82b3\u70c3\uff09\uff0c\u5728\u53cd\u5e94\u4e2d\u88ab\u517c\u5bb9\u4e0b\u6765\u3002\u4f20\u7edf\u6c30\u70f7\u57fa\u5316\u53cd\u5e94\u96be\u4ee5\u517c\u5bb9\u7684\u4eb2\u7535\u6027\u5364\u4ee3\u70f7\u70c3\u3001\u5364\u4ee3\u82b3\u70c3\uff0c\u5728\u8be5\u53cd\u5e94\u4e2d\u540c\u6837\u88ab\u517c\u5bb9\u4e0b\u6765\u3002\u4f18\u5f02\u7684\u5b98\u80fd\u56e2\u517c\u5bb9\u6027\uff0c\u53ef\u80fd\u662f\u7531\u4e8e\u6781\u4f4e\u7684\u53cd\u5e94\u6e29\u5ea6\u548c\u6781\u77ed\u7684\u53cd\u5e94\u65f6\u95f4\u62df\u5236\u4e86\u526f\u53cd\u5e94\u7684\u53d1\u751f\u3002<\/span><\/p>\n

\"\u3010\u6709\u673a\u3011\u7ecf\u7531\u9ad8\u901f[3,3]-<\/p>\n


<\/p>\n

\u4ea7\u7269\u4e2d\u88ab\u4fdd\u7559\u7684\u82b3\u57fa\u7898\u4ee5\u53ca\u5f15\u5165\u7684\u6c30\u70f7\u57fa\u90fd\u5177\u6709\u826f\u597d\u7684\u5b98\u80fd\u56e2\u884d\u751f\u6027\u3002\u53cd\u5e94\u4ea7\u7269\u7ecf\u8fc7\u7b80\u5355\u4fee\u9970\uff0c\u53ef\u4ee5\u7ed9\u51fa\u4e00\u7cfb\u52171,2-\u4e8c\u53d6\u4ee3\u82b3\u70c3\uff0c\u5176\u4e2d\u5305\u62ec\u836f\u7269\u524d\u4f53TUG-488\u548c\u6297\u708e\u836f\u7269Diclofenac\uff0c\u53cc\u6c2f\u82ac\u9178\u94a0\u3002 <\/span><\/p>\n

\"\u3010\u6709\u673a\u3011\u7ecf\u7531\u9ad8\u901f[3,3]-<\/p>\n


<\/p>\n

\u4e2d\u56fd\u79d1\u5b66\u9662\u5927\u5b66\u6c6a\u5fd7\u7965<\/strong>\u7814\u7a76\u5458\u901a\u8fc7\u7406\u8bba\u8ba1\u7b97\u7814\u7a76\u4e86\u53cd\u5e94\u7684\u6574\u4e2a\u8fc7\u7a0b\u3002\u53d1\u73b0\u5173\u952e\u7684[3,3]-sigmatropic\u91cd\u6392\u6b65\u9aa4\u80fd\u5792\u53ea\u67092.1 kcal\/mol\u3002\u7406\u8bba\u8ba1\u7b97\u7684\u7ed3\u679c\u4e0e\u5b9e\u9a8c\u4e8b\u5b9e\u76f8\u4e92\u543b\u5408\u3002\u7531\u6b64\uff0c\u5f6d\u52c3<\/strong>\u8bfe\u9898\u7ec4\u518d\u6b21\u5229\u7528\u5f20\u529b\u91ca\u653e\u4fc3\u8fdb\u91cd\u6392\u7684\u7b56\u7565\uff0c\u53d1\u5c55\u4e86\u82b3\u70c3\u6c30\u70f7\u57fa\u5316\u53cd\u5e94\u3002<\/span><\/p>\n


<\/p>\n

\u8be5\u8bba\u6587\u4f5c\u8005\u4e3a\uff1a<\/span><\/strong>Junsong Tian, Fan Luo, Chaoshen Zhang, Xin Huang, Yage Zhang, Lei Zhang, Lichun Kong, Xiaochun Hu, Zhi-Xiang Wang, Bo Peng<\/span><\/p>\n

\u539f\u6587\uff08\u626b\u63cf\u6216\u957f\u6309\u4e8c\u7ef4\u7801\uff0c\u8bc6\u522b\u540e\u76f4\u8fbe\u539f\u6587\u9875\u9762\uff09\uff1a<\/span><\/p>\n

\"\u3010\u6709\u673a\u3011\u7ecf\u7531\u9ad8\u901f[3,3]-<\/p>\n

Selective ortho<\/em> C\u2212H Cyanoalkylation of (Diacetoxyiodo)arenes through [3,3]-Sigmatropic Rearrangement<\/span><\/p>\n

Angew. Chem. Int. Ed.<\/span><\/em>, 2018<\/strong>, 57<\/em>, 9078, DOI: 10.1002\/anie.201803455<\/span><\/p>\n


<\/span><\/p>\n

\u5bfc\u5e08\u4ecb\u7ecd<\/span><\/p>\n

\u5f6d\u52c3<\/span><\/p>\n

http:\/\/www.x-mol.com\/university\/faculty\/41618<\/span><\/p>\n

\u6c6a\u5fd7\u7965<\/span><\/p>\n

http:\/\/www.x-mol.com\/university\/faculty\/23714<\/span><\/p>\n


<\/p>\n

\n
\n
\n
\n

\"\u3010\u6709\u673a\u3011\u7ecf\u7531\u9ad8\u901f[3,3]-<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\"\u3010\u6709\u673a\u3011\u7ecf\u7531\u9ad8\u901f[3,3]-<\/p>\n

\n
\n
\n
\n
<\/section>\n
<\/section>\n
<\/section>\n<\/section>\n
\n
\n
\n
\n

\u672c\u6587\u7248\u6743\u5c5e\u4e8eX-MOL<\/strong><\/span>\uff08x-mol.com\uff09\uff0c\u672a\u7ecf\u8bb8\u53ef\u8c22\u7edd\u8f6c\u8f7d\uff01\u6b22\u8fce\u8bfb\u8005\u670b\u53cb\u4eec\u5206\u4eab\u5230\u670b\u53cb\u5708or\u5fae\u535a\uff01<\/span><\/p>\n


<\/p>\n

\u957f\u6309<\/strong><\/span>\u4e0b\u56fe\u8bc6\u522b\u56fe\u4e2d\u4e8c\u7ef4\u7801<\/strong>\uff0c\u8f7b\u677e\u5173\u6ce8\u6211\u4eec\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

\n<\/section>\n<\/section>\n

\n
<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587<\/span>\u201d\uff0c\u67e5\u770b \u5316\u5b66 \u2022 \u6750\u6599 <\/strong>\u9886\u57df\u6240\u6709\u6536\u5f55\u671f\u520a<\/span><\/span><\/p>\n

<\/span>\"\u3010\u6709\u673a\u3011\u7ecf\u7531\u9ad8\u901f[3,3]-<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a X\u4e00MOL\u8d44\u8baf <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u200d\u200d\u200d \u03b1-\u82b3\u57fa\u8148\u53ca\u5176\u884d\u7269\u5728\u836f\u7269\u548c\u5929\u7136\u4ea7\u7269\u4e2d\u6709\u7740\u5e7f\u6cdb\u5206\u5e03\u3002\u901a\u8fc7\u7b80\u5355\u7684\u6c34\u89e3\u6216\u8fd8\u539f\uff0c\u03b1-\u82b3\u57fa\u8148\u53ef\u4ee5\u8f6c\u5316\u4e3a\u03b1-\u82b3\u57fa\u9170 […]<\/p>\n","protected":false},"author":1,"featured_media":29088,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29087"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=29087"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29087\/revisions"}],"predecessor-version":[{"id":29103,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29087\/revisions\/29103"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/29088"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=29087"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=29087"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=29087"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}