{"id":29195,"date":"2018-08-08T01:00:00","date_gmt":"2018-08-09T03:59:46","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e7%9b%98%e7%82%b9-%e4%b8%80%e6%96%87%e7%9c%8b%e6%87%82%e8%82%bf%e7%98%a4%e9%9d%b6%e5%90%91%e7%96%97%e6%b3%95%e4%b8%83%e5%a4%a7%e6%9c%80%e6%96%b0%e8%bf%9b%e5%b1%95\/"},"modified":"2018-08-09T11:59:48","modified_gmt":"2018-08-09T03:59:48","slug":"%e7%9b%98%e7%82%b9-%e4%b8%80%e6%96%87%e7%9c%8b%e6%87%82%e8%82%bf%e7%98%a4%e9%9d%b6%e5%90%91%e7%96%97%e6%b3%95%e4%b8%83%e5%a4%a7%e6%9c%80%e6%96%b0%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/29195\/","title":{"rendered":"\u76d8\u70b9 | \u4e00\u6587\u770b\u61c2\u80bf\u7624\u9776\u5411\u7597\u6cd5\u4e03\u5927\u6700\u65b0\u8fdb\u5c55"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<h1 style=\"margin-bottom: 0.8em;font-weight: inherit;font-size: 1.7em;white-space: normal;box-sizing: border-box;word-wrap: break-word;border-width: 0px;border-style: initial;border-color: initial;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;line-height: inherit;\"><strong><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u258e\u836f\u660e<\/span><\/strong><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n<\/p>\n<p style=\"text-align: center;\"><strong><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><span style=\"font-size: 14px;color: rgb(178, 178, 178);\">\u56fe\u7247\u6765\u6e90\uff1a123RF<\/span><\/p>\n<p><strong><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n<p><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">1\u3001\u8f89\u745eCDK4\/6\u6291\u5236\u5242\u7231\u535a\u65b0\u00ae\uff08\u54cc\u67cf\u897f\u5229\uff09\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02<\/span><\/strong><br  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8f89\u745e\u516c\u53f8\u5ba3\u5e03\uff0c<strong>\u5168\u7403\u9996\u4e2a\u7ec6\u80de\u5468\u671f\u86cb\u767d\u4f9d\u8d56\u6027\u6fc0\u9176\uff08CDK\uff094\/6\u6291\u5236\u5242\u7231\u535a\u65b0\u00ae IBRANCE\u00ae\uff08\u54cc\u67cf\u897f\u5229, palbociclib\uff09\u5df2\u4e8e7\u670831\u65e5\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40<\/strong><\/span><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxMTY5MzM5OQ==&amp;mid=2247484577&amp;idx=1&amp;sn=50f6e9f4e307867501ec4639a4f1e371&amp;chksm=f96e8399ce190a8f5018dc42de2fe45ef1e208e2cc84e26319dbd4447f35a4ded1ed01983579&amp;scene=21#wechat_redirect\" target=\"_blank\"><span style=\"font-size: 15px;color: rgb(0, 112, 192);text-decoration: underline;\"><strong>\u6279\u51c6<\/strong><\/span><\/a><span style=\"font-size: 15px;\"><strong>\u3002<\/strong>\u7231\u535a\u65b0\u00ae\u9002\u7528\u4e8e\u6cbb\u7597\u6fc0\u7d20\u53d7\u4f53\uff08HR\uff09\u9633\u6027\u3001\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\uff08HER2\uff09\u9634\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff0c\u5e94\u4e0e\u82b3\u9999\u5316\u9176\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\u4f5c\u4e3a\u7edd\u7ecf\u540e\u5973\u6027\u60a3\u8005\u7684\u521d\u59cb\u5185\u5206\u6ccc\u6cbb\u7597\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">2\u3001\u82f1\u6d3e\u836f\u4e1a\u5b8c\u62103000\u4e07\u7f8e\u5143C\u8f6e\u878d\u8d44\uff0c\u63a8\u52a8PARP\u6291\u5236\u5242\u8fdb\u5165\u4e34\u5e8a<\/span><\/strong><\/p>\n<p><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5357\u4eac\u82f1\u6d3e\u836f\u4e1a\u6709\u9650\u516c\u53f8\u8fd1\u65e5\u5ba3\u5e03\u5df2\u6210\u529f\u5b8c\u62103000\u4e07\u7f8e\u5143<\/span><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzIzMTU0NTM5MA==&amp;mid=2247489251&amp;idx=2&amp;sn=68ebccbdeeecf64f18cf18b7490f61cc&amp;chksm=e8a3d9a2dfd450b4e11bc2337650f92180c1cc6b10cad1a99cda6d893fc1a4a04f1612d6c1f4&amp;scene=21#wechat_redirect\" target=\"_blank\"><span style=\"font-size: 15px;color: rgb(0, 112, 192);text-decoration: underline;\">C\u8f6e\u878d\u8d44<\/span><\/a><span style=\"font-size: 15px;\">\u3002\u672c\u8f6e\u878d\u8d44\u7531\u5fb7\u8bda\u8d44\u672c\u9886\u6295\uff0c\u793c\u6765\u4e9a\u6d32\u57fa\u91d1\u8ddf\u6295\u3002<strong>\u7b79\u96c6\u7684\u8d44\u91d1\u5c06\u4e3b\u8981\u7528\u4e8e\u52a0\u901f\u63a8\u8fdb\u5177\u6709&#8221;best-in-class&#8221;\u6f5c\u529b\u7684PARP\u6291\u5236\u5242IMP4297\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/strong>\uff0c\u4ee5\u53ca\u5176\u5b83\u9879\u76ee\u3002\u82f1\u6d3e\u836f\u4e1a\u4ee5DNA\u635f\u4f24\u5e94\u7b54 (DNA Damage Response, DDR) \u4e3a\u91cd\u70b9\u9776\u6807\u642d\u5efa\u7814\u53d1\u5e73\u53f0\uff0c\u6784\u5efa\u72ec\u7279\u7684\u4ea7\u54c1\u7ba1\u7ebf\u3002\u5176\u4e3b\u6253\u4ea7\u54c1PARP\u6291\u5236\u5242IMP4297\u6b63\u5728\u4e2d\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u540c\u65f6\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u3002\u4e34\u5e8a\u524d\u6570\u636e\u548c\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u663e\u793a\uff0c\u4e0e\u5176\u5b83\u5df2\u4e0a\u5e02\u7684PARP\u6291\u5236\u5242\u76f8\u6bd4\uff0cIMP4297\u5728\u4e34\u5e8a\u4e0a\u53ef\u80fd\u6709\u66f4\u597d\u7684\u836f\u6548\u548c\u66f4\u4f4e\u7684\u6bd2\u6027\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">3\u3001\u6765\u51ef\u533b\u836f\u83b7\u8bfa\u534e\u4e24\u6b3eAkt\u6fc0\u9176\u6291\u5236\u5242\u7684\u5168\u7403\u72ec\u5bb6\u6743\u76ca<\/span><\/strong><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u56fd\u5185\u521b\u65b0\u836f\u7814\u53d1\u65b0\u9510\u516c\u53f8\u6765\u51ef\u533b\u836f\uff08Laekna\uff09\u4e0e\u5168\u7403\u6027\u533b\u836f\u516c\u53f8\u8bfa\u534e<\/span><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxMTY5MzM5OQ==&amp;mid=2247484545&amp;idx=1&amp;sn=2e606e67b0f65c518d68b61798af7c95&amp;chksm=f96e83b9ce190aafbd361f49d67b7d886f73e2ebd4bf9b26d30ff569755bc6fbce41d9a78604&amp;scene=21#wechat_redirect\" target=\"_blank\"><span style=\"font-size: 15px;color: rgb(0, 112, 192);text-decoration: underline;\">\u7b7e\u7f72\u534f\u8bae<\/span><\/a><span style=\"font-size: 15px;\">\uff0c\u6765\u51ef\u533b\u836f\u5c06\u83b7\u5f97\u8bfa\u534e\u65d7\u4e0b\u4e24\u6b3e\u80bf\u7624\u9879\u76ee\u8d44\u4ea7\u7684\u5168\u7403\u72ec\u5bb6\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u5229\uff0c\u4e0e\u6b64\u540c\u65f6\uff0c\u8bfa\u534e\u5c06\u6301\u6709\u6765\u51ef\u533b\u836f\u7684\u80a1\u6743\uff0c\u5e76\u5c06\u83b7\u5f97\u524d\u671f\u7684\u5f00\u53d1\u91cc\u7a0b\u7891\u4ed8\u6b3e\u4ee5\u53ca\u672a\u6765\u7684\u9500\u552e\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002\u8be5\u534f\u8bae\u6761\u6b3e\u7684\u7ec6\u8282\u5c1a\u672a\u62ab\u9732\u3002\u636e\u4ecb\u7ecd\uff0c<\/span><strong style=\"font-size: 15px;\">\u8fd9\u4e24\u6b3e\u5019\u9009\u836f\u7269\u4e3a\u53e3\u670d\u6cdbAkt\u6fc0\u9176\u6291\u5236\u5242afuresertib\uff08ASB183\uff09\u548cuprosertib\uff08UPB795\uff09\u3002<\/strong><span style=\"font-size: 15px;\">\u76ee\u524d\uff0c\u8fd9\u4e24\u6b3e\u5019\u9009\u836f\u7269\u768410\u591a\u9879\u4e34\u5e8a1\/2\u671f\u7814\u7a76\u5df2\u5728\u591a\u79cd\u764c\u75c7\u4e2d\u8fdb\u884c\uff0c\u5305\u62ec\u5375\u5de2\u764c\u3001\u80c3\u764c\u3001\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3001\u9ed1\u8272\u7d20\u7624\u7b49\u9002\u5e94\u75c7\u3002\u8fd9\u4e9b\u8bd5\u9a8c\u8868\u660e\uff0c\u5019\u9009\u836f\u7269\u5728\u764c\u75c7\u60a3\u8005\u7684\u4e34\u5e8a\u7597\u6548\u548c\u8010\u53d7\u5b89\u5168\u6027\u65b9\u9762\u53d6\u5f97\u4e86\u79ef\u6781\u7684\u7ed3\u679c\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">4\u3001HiFiBiO\u4e0e\u65e5\u672c\u6b66\u7530\u5408\u4f5c\u5f00\u53d1\u591a\u9776\u70b9\u836f\u7269<\/span><\/strong><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7f8e\u56fd\u836f\u4f01HiFiBiO Therapeutics\u5ba3\u5e03\u5df2\u4e0e\u65e5\u672c\u6b66\u7530\u7b7e\u8ba2\u5408\u4f5c\u534f\u8bae\uff0c\u5171\u540c\u5f00\u53d1\u4e00\u79cd\u591a\u9776\u70b9\u836f\u7269\u3002\u6839\u636e\u534f\u8bae\uff0c<strong>HiFiBiO\u5c06\u5229\u7528\u5176\u65b0\u578b\u5355\u4e2aB\u7ec6\u80de\u6297\u4f53\u5236\u5907\u6280\u672f\uff0c\u5f00\u53d1\u7a81\u7834\u6027\u7684\u6297\u4f53\u836f\u7269\u6cbb\u7597\u80c3\u80a0\u9053\u75be\u75c5\uff0c\u764c\u75c7\u7b49\u75be\u75c5\u3002<\/strong>\u540c\u65f6\uff0c\u6b66\u7530\u5c06\u652f\u4ed8HiFiBiO\u672a\u900f\u9732\u5177\u4f53\u6570\u76ee\u7684\u9884\u4ed8\u6b3e\uff0c\u91cc\u7a0b\u7891\u4ed8\u6b3e\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002<\/span><span style=\"font-size: 15px;\">HiFiBiO\u5728\u4e2d\u56fd\u4e0a\u6d77\u3001\u7f8e\u56fd\u548c\u6cd5\u56fd\u4e09\u5730\u5b9e\u9a8c\u5ba4\u5f00\u5c55\u7814\u7a76\uff0c\u4e13\u6ce8\u4e8e\u4f7f\u7528\u5176\u72ec\u6709\u7684CelliGOTM\u5e73\u53f0\u5f00\u53d1\u514d\u75ab\u8c03\u8282\u6297\u4f53\u836f\u7269\u3002\u8be5\u516c\u53f8\u4e8e\u4eca\u5e745\u6708\u5b8c\u6210\u4e863750\u4e07\u7f8e\u5143\u7684B\u8f6e\u878d\u8d44\uff0c\u7531\u7ea2\u6749\u8d44\u672c\u4e2d\u56fd\u57fa\u91d1\u548c\u6d4e\u5cf0\u8d44\u672c\u9886\u6295\uff1b\u672c\u8f6e\u878d\u8d44\u4e5f\u5f97\u5230\u4e86\u73b0\u6709A\u8f6e\u6295\u8d44\u8005\u5f18\u52b1\u521b\u6295\u548cNest.Bio Ventures\u3001\u4ee5\u53ca\u65b0\u6295\u8d44\u8005\u8054\u60f3\u4e4b\u661f\u548c\u6bd4\u90bb\u661f\u521b\u6295\u7684\u53c2\u6295\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(255, 255, 255);\">\u672c\u6587\u6765\u6e90\uff1a\u836f\u660e\u5eb7\u5fb7<\/span><\/p>\n<p><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">5\u3001\u57fa\u77f3\u836f\u4e1aMEK\u6291\u5236\u5242\u5728\u4e2d\u56fd\u83b7\u4e34\u5e8a\u6279\u4ef6<\/span><\/strong><br  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u57fa\u77f3\u836f\u4e1a\u81ea\u4e3b\u7814\u53d1\u7684\u5c0f\u5206\u5b50MEK1\/2\u6291\u5236\u5242CS3006\u7684<\/span><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxMTY5MzM5OQ==&amp;mid=2247484530&amp;idx=2&amp;sn=49df8b39ebc9eb2a5e3fbc4b4b536a80&amp;chksm=f96e834ace190a5cbf2b3b5d6acbf803e794396be5fc425a60cf4212f5e970fb0aa2d7478083&amp;scene=21#wechat_redirect\" target=\"_blank\"><span style=\"font-size: 15px;color: rgb(0, 112, 192);text-decoration: underline;\">\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7<\/span><\/a><span style=\"font-size: 15px;\">\u5df2\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u3002<strong>CS3006\u662f\u7531\u57fa\u77f3\u836f\u4e1a\u72ec\u7acb\u5f00\u53d1\u7684\u4e00\u79cd\u5177\u6709\u9ad8\u5ea6\u9009\u62e9\u6027\u7684MEK1\/2\u6291\u5236\u5242<\/strong>\uff0cCS3006\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u4e8e\u4eca\u5e746\u6708\u5728\u6fb3\u5927\u5229\u4e9a\u542f\u52a8\uff0c\u662f\u7ee7CS1003\u4e4b\u540e\uff0c\u7b2c\u4e8c\u4e2a\u5728\u6d77\u5185\u5916\u540c\u6b65\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5019\u9009\u836f\u7269\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 15px;color: rgb(0, 112, 192);\"><strong>6\u3001\u4fe1\u8fbe\u751f\u7269OX40\u5355\u6297\u548cRANKL\u5355\u6297\u540c\u65f6\u83b7\u6279\u4e34\u5e8a<\/strong><\/span><\/p>\n<p><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4fe1\u8fbe\u751f\u7269\u5236\u836f\u6709\u9650\u516c\u53f8\u5f00\u53d1\u7684\u6ce8\u5c04\u7528\u91cd\u7ec4\u5168\u4eba\u6e90\u6297OX40\u5355\u514b\u9686\u6297\u4f53\uff08\u7814\u53d1\u4ee3\u53f7IBI101\uff09\u548c\u91cd\u7ec4\u5168\u4eba\u6e90\u6297RANKL\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\uff08\u7814\u53d1\u4ee3\u53f7IBI307\uff09\u540c\u65f6\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u9881\u53d1\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\u3002<strong>OX40\u662f\u6297\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u91cd\u8981\u9776\u70b9\u4e4b\u4e00\uff0c\u5168\u7403\u76ee\u524d\u5c1a\u65e0\u9488\u5bf9\u8fd9\u4e00\u9776\u70b9\u7684\u5355\u6297\u836f\u7269\u83b7\u6279\u4e0a\u5e02\u3002<\/strong>IBI101\u662f\u4fe1\u8fbe\u751f\u7269\u7814\u53d1\u7684\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684OX40\u6fc0\u52a8\u5242\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u80bf\u7624\u75be\u75c5\u3002IBI307\u662f\u91cd\u7ec4\u5168\u4eba\u6e90\u6297RANKL\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\uff0c\u4fe1\u8fbe\u751f\u7269\u62df\u5f00\u53d1\u8be5\u836f\u7528\u4e8e\u6cbb\u7597\u9aa8\u8d28\u758f\u677e\u548c\u4e0e\u764c\u75c7\u8f6c\u79fb\u76f8\u5173\u7684\u6eb6\u89e3\u6027\u9aa8\u635f\u5bb3\u3002\u76ee\u524d\u56fd\u5185\u5c1a\u672a\u6709RANKL\u6297\u4f53\u836f\u7269\u83b7\u6279\u4e0a\u5e02\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">7\u3001\u5929\u5883\u751f\u7269\u4e0eABL Bio\u5c31\u521b\u65b0\u53cc\u7279\u5f02\u6027\u6297\u4f53\u8fbe\u6210\u5168\u7403\u6218\u7565\u5408\u4f5c&nbsp;<\/span><\/strong><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5929\u5883\u751f\u7269\u4e0e\u97e9\u56fd\u751f\u7269\u6280\u672f\u516c\u53f8ABL Bio\u516c\u53f8\u5c31\u5929\u5883\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff08BsAb\uff09\u9879\u76ee\u5efa\u7acb\u5168\u7403\u6218\u7565\u5408\u4f5c\u5173\u7cfb\u3002\u6839\u636e\u534f\u8bae\uff0cABL Bio\u5c06\u83b7\u5f97\u8be5\u9879\u76ee\u9664\u5927\u4e2d\u534e\u5730\u533a\u4ee5\u5916\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u76ca\uff0cABL Bio\u5c06\u4e3a\u6b64\u652f\u4ed8\u9ad8\u8fbe\u5927\u7ea61\u4ebf\u7f8e\u5143\u7684\u603b\u6388\u6743\u91d1\u989d\uff0c\u5305\u62ec\u9884\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u7814\u53d1\u3001\u6ce8\u518c\u548c\u9500\u552e\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002<strong>\u672c\u6b21\u5408\u4f5c\u5305\u62ec\u56db\u4e2a\u53cc\u7279\u5f02\u6027\u6297\u4f53\u9879\u76ee\uff0c\u5177\u4f53\u9776\u70b9\u672a\u900f\u9732\u3002<\/strong>\u5929\u5883\u548cABL Bio\u5c06\u5171\u540c\u63a8\u8fdb\u9879\u76ee\u7814\u53d1\u5de5\u4f5c\uff0c\u5e76\u4e14\u5728\u4e2d\u56fd\u3001\u97e9\u56fd\u53ca\u5168\u7403\u5176\u4ed6\u5730\u533a\u4ee5\u4e0d\u540c\u5f62\u5f0f\u5171\u540c\u5206\u62c5\u7814\u53d1\u8d39\u7528\u5e76\u5171\u4eab\u4ea7\u54c1\u6743\u76ca\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1] <span style=\"color: rgb(178, 178, 178);font-size: 10px;white-space: pre;\">\t<\/span>\u8f89\u745e\u4e73\u817a\u764c\u6cbb\u7597\u7a81\u7834\u6027\u521b\u65b0\u836f\u7231\u535a\u65b0\u00ae\uff08\u54cc\u67cf\u897f\u5229\uff09\u5728\u4e2d\u56fd\u83b7\u6279,Retrieved August,6,2018,from http:\/\/www.pfizer.com.cn\/(S(k5oqqtabzrt0xk2yzf4duv3y))\/news\/news_cn.aspx?id=582<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2] <span style=\"color: rgb(178, 178, 178);font-size: 10px;white-space: pre;\">\t<\/span>\u82f1\u6d3e\u836f\u4e1a\u6210\u529f\u5b8c\u62103000\u4e07\u7f8e\u5143C\u8f6e\u878d\u8d44,Retrieved August,3,2018,from https:\/\/www.prnasia.com\/story\/218787-1.shtml<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[3] <span style=\"color: rgb(178, 178, 178);font-size: 10px;white-space: pre;\">\t<\/span>\u57fa\u77f3\u836f\u4e1a\u81ea\u4e3b\u7814\u53d1\u7684MEK\u6291\u5236\u5242CS3006\u5728\u4e2d\u56fd\u83b7\u5f97\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6,Retrieved July,30,2018,from https:\/\/www.prnasia.com\/story\/218251-1.shtml<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[4] <span style=\"color: rgb(178, 178, 178);font-size: 10px;white-space: pre;\">\t<\/span>Novartis dispatches two more cancer drug castoffs to a partner in China.Retrieved August 1, 2018,from https:\/\/endpts.com\/novartis-dispatches-two-more-cancer-drug-castoffs-to-a-partner-in-china\/<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[5] <span style=\"color: rgb(178, 178, 178);font-size: 10px;white-space: pre;\">\t<\/span>After its recent funding round, HiFiBiO pens Takeda R&amp;D collab. Retrieved July 30, 2018,from https:\/\/www.fiercebiotech.com\/biotech\/after-its-recent-funding-round-hifibio-pens-takeda-r-d-collab<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[6] <span style=\"color: rgb(178, 178, 178);font-size: 10px;white-space: pre;\">\t<\/span>\u5929\u5883\u751f\u7269\u4e0eABL Bio\u5c31\u521b\u65b0\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5f00\u53d1\u9879\u76ee\u5efa\u7acb\u5168\u7403\u6218\u7565\u5408\u4f5c\u5173\u7cfb.Retrieved July 26, 2018,from http:\/\/www.i-mabbiopharma.com\/shownews.asp?id=18&amp;bigclass=%E6%96%B0%E9%97%BB%E5%8A%A8%E6%80%81<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[7] <span style=\"color: rgb(178, 178, 178);font-size: 10px;white-space: pre;\">\t<\/span>\u4fe1\u8fbe\u751f\u7269\u4e24\u4e2a\u5355\u514b\u9686\u6297\u4f53\u540c\u83b7\u4e34\u5e8a\u6279\u4ef6.Retrieved July 26, 2018,from http:\/\/innoventbio.com\/#\/news\/96<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);line-height: normal;\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;word-wrap: break-word !important;\">\u672c\u6587\u6765\u81ea\u836f\u660e\u5eb7\u5fb7\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"__bg_gif\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533787187.gif\" alt=\"\u76d8\u70b9 | \u4e00\u6587\u770b\u61c2\u80bf\u7624\u9776\u5411\u7597\u6cd5\u4e03\u5927\u6700\u65b0\u8fdb\u5c55\" title=\"\u76d8\u70b9 | \u4e00\u6587\u770b\u61c2\u80bf\u7624\u9776\u5411\u7597\u6cd5\u4e03\u5927\u6700\u65b0\u8fdb\u5c55\"  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u660e\u5eb7\u5fb7                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u56fe\u7247\u6765\u6e90\uff1a123RF 1\u3001\u8f89\u745eCDK4\/6\u6291\u5236\u5242\u7231\u535a\u65b0\u00ae\uff08\u54cc\u67cf\u897f\u5229\uff09\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02 \u8f89\u745e\u516c\u53f8 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":29196,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29195"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=29195"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29195\/revisions"}],"predecessor-version":[{"id":29202,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29195\/revisions\/29202"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/29196"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=29195"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=29195"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=29195"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}