{"id":29203,"date":"2018-08-08T01:00:00","date_gmt":"2018-08-09T03:59:50","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e7%9b%98%e7%82%b9-%e8%82%bf%e7%98%a4%e9%a2%86%e5%9f%9f%e8%bf%91%e6%9c%9f%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e6%b1%87%e6%80%bb%ef%bc%88%e7%ac%ac74%e6%9c%9f%ef%bc%89\/"},"modified":"2018-08-09T11:59:52","modified_gmt":"2018-08-09T03:59:52","slug":"%e7%9b%98%e7%82%b9-%e8%82%bf%e7%98%a4%e9%a2%86%e5%9f%9f%e8%bf%91%e6%9c%9f%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e6%b1%87%e6%80%bb%ef%bc%88%e7%ac%ac74%e6%9c%9f%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/29203\/","title":{"rendered":"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c74\u671f\uff09"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><strong style=\"white-space: normal;font-size: 15px;max-width: 100%;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u258e\u836f\u660e<\/span><\/strong><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n<p><strong style=\"white-space: normal;font-size: 15px;max-width: 100%;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">1. \u518d\u751f\u5143\u4e0ebluebird bio\u8054\u624b\u5f00\u53d1\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7597\u6cd5<\/span><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u65e5\u524d\uff0c<strong>\u518d\u751f\u5143\uff08Regeneron Pharmaceuticals\uff09\u548cbluebird bio\u5ba3\u5e03\u8fdb\u884c\u5408\u4f5c\uff0c\u5c06\u5404\u81ea\u7684\u6280\u672f\u5e73\u53f0\u5e94\u7528\u4e8e\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u7684\u53d1\u73b0\u3001\u5f00\u53d1\u548c\u63a8\u5e7f\u3002<\/strong>\u6b64\u6b21\u5408\u4f5c\u5c06\u5229\u7528\u518d\u751f\u5143\u7684VelociSuite\u00ae\u5e73\u53f0\u6280\u672f\u53d1\u73b0\u548c\u8868\u5f81\u5168\u4eba\u6297\u4f53\uff0c\u4ee5\u53ca\u9488\u5bf9\u80bf\u7624\u7279\u5f02\u6027\u86cb\u767d\u548c\u591a\u80bd\u7684T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\uff0cbluebird bio\u5c06\u8d21\u732e\u5176\u5728\u57fa\u56e0\u8f6c\u79fb\u548c\u7ec6\u80de\u7597\u6cd5\u9886\u57df\u7684\u9886\u5148\u4e13\u4e1a\u77e5\u8bc6\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><img   class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress1-1533787191.jpeg\" alt=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c74\u671f\uff09\" title=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c74\u671f\uff09\"  \/><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u53ef\u4ee5\u7279\u5f02\u6027\u9488\u5bf9\u5e76\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u4f8b\u5982\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\uff08CAR-Ts\uff09\u662f\u5bf9\u4eba\u514d\u75ab\u7ec6\u80de\uff08\u901a\u5e38\u6765\u81ea\u764c\u75c7\u60a3\u8005\u7684T\u7ec6\u80de\uff09\u8fdb\u884c\u4fee\u9970\uff0c\u518d\u4f5c\u4e3a\u6cbb\u7597\u5242\u56de\u8f93\u7ed9\u60a3\u8005\u3002\u5728\u8fdb\u4e00\u6b65\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u8bc1\u660e\uff0c\u5373\u4f7f\u5176\u4ed6\u6cbb\u7597\u65b9\u6cd5\u90fd\u5931\u8d25\u4e86\uff0c\u6539\u826fT\u7ec6\u80de\u4f9d\u65e7\u662f\u591a\u79cd\u8840\u764c\u60a3\u8005\u7684\u9ad8\u6548\u6cbb\u7597\u836f\u7269\uff0c\u5e76\u4e14\u73b0\u5728\u5df2\u7ecf\u83b7\u5f97FDA\u7684\u6279\u51c6\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">bluebird bio\u7684\u6280\u672f\u4f7f\u7528\u5b9a\u5236\u7684\u6162\u75c5\u6bd2\u8f7d\u4f53\u6765\u4fee\u9970T\u7ec6\u80de\uff0c\u6240\u4ee5\u5b83\u4eec\u80fd\u591f\u8bc6\u522b\u7531\u764c\u7ec6\u80de\u8868\u8fbe\u7684\u80bf\u7624\u7279\u5f02\u6027\u86cb\u767d\uff0c\u5e76\u5728\u63a5\u5408\u65f6\u6740\u6b7b\u5b83\u4eec\u3002\u518d\u751f\u5143\u7684VelociSuite\u00ae\u6280\u672f\uff08\u5305\u62ecVelocImmune\u00ae\u548cVeloci-T\uff09\u53ef\u4ee5\u4ea7\u751f\u5168\u4eba\u6297\u4f53\u548cT\u7ec6\u80de\u53d7\u4f53\u3002\u8fd9\u4e9b\u4e92\u8865\u6280\u672f\u6709\u671b\u901a\u8fc7\u4f7fT\u7ec6\u80de\u5230\u8fbe\u7ec6\u80de\u5916\u548c\u7ec6\u80de\u5185\u7684\u80bf\u7624\u6297\u539f\uff0c\u6765\u6269\u5c55\u6539\u826fT\u7ec6\u80de\u80fd\u5b89\u5168\u6709\u6548\u9776\u5411\u7684\u80bf\u7624\u7c7b\u578b\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">\u4e24\u5bb6\u516c\u53f8\u5171\u540c\u9009\u62e9\u4e866\u4e2a\u521d\u59cb\u9776\u6807\uff0c\u5e76\u5c06\u5e73\u5747\u5206\u62c5\u7814\u53d1\u6210\u672c\uff0c\u76f4\u81f3\u63d0\u4ea4\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09\u7533\u8bf7\u3002<\/span><\/strong><span style=\"font-size: 15px;\">\u57285\u5e74\u7684\u7814\u7a76\u5408\u4f5c\u671f\u5185\uff0c\u4e24\u5bb6\u516c\u53f8\u8fd8\u53ef\u4ee5\u9009\u62e9\u5176\u4ed6\u9776\u6807\u3002\u5f53\u6f5c\u5728\u7684\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u63d0\u4ea4IND\u65f6\uff0c\u518d\u751f\u5143\u5c06\u6709\u6743\u9009\u62e9\u53c2\u4e0e\u67d0\u4e9b\u5408\u4f5c\u9776\u6807\u7684\u5171\u540c\u5f00\u53d1\/\u5171\u540c\u63a8\u5e7f\u3002\u5982\u679c\u518d\u751f\u5143\u6ca1\u6709\u9009\u62e9\u53c2\u4e0e\uff0c\u5b83\u5c06\u6709\u8d44\u683c\u83b7\u5f97bluebird bio\u5bf9\u4efb\u4f55\u6f5c\u5728\u4ea7\u54c1\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\u548c\u7279\u8bb8\u6743\u4f7f\u7528\u8d39\u3002\u6b64\u5916\uff0c\u518d\u751f\u5143\u8fd8\u5c06\u5bf9bluebird bio\u8fdb\u884c\u603b\u989d\u4e3a1\u4ebf\u7f8e\u5143\u7684\u6295\u8d44&nbsp;<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">2. \u9776\u5411FLT3\uff0c\u767d\u8840\u75c5\u65b0\u836f\u83b7\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a<\/span><\/strong><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">\u7b2c\u4e00\u4e09\u5171\u516c\u53f8\uff08Daiichi Sankyo\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0cFDA\u5df2\u6388\u4e88\u5176\u5728\u7814\u65b0\u836fquizartinib\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u3002<\/span><\/strong><span style=\"font-size: 15px;\">Quizartinib\u662f\u4e00\u6b3eFLT3\u6291\u5236\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027<em>FLT3<\/em>-ITD\u6025\u6027\u9aa8\u9ad3\u6027\u767d\u8840\u75c5\uff08<em>FLT3<\/em>-ITD r\/r AML\uff09\u7684\u6210\u5e74\u60a3\u8005\u3002\u672c\u6b21\u8ba4\u5b9a\u5c06\u52a0\u901f\u9488\u5bf9quizartinib\u7684\u7814\u53d1\uff0c\u6709\u671b\u65e9\u65e5\u4e3a\u60a3\u8005\u5e26\u6765\u65b0\u836f\u3002<strong>\u9664\u4e86\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0cquizartinib\u9488\u5bf9r\/r AML\u7597\u6cd5\u8fd8\u83b7\u5f97\u4e86FDA\u7684\u5feb\u901f\u901a\u9053\u8d44\u683c\uff0c\u4ee5\u53caFDA\u4e0e\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u9881\u53d1\u7684\u9488\u5bf9AML\u7684\u5b64\u513f\u836f\u8d44\u683c\u3002<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><img   class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress1-1533787191.jpg\" alt=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c74\u671f\uff09\" title=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c74\u671f\uff09\"  \/><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">AML\u662f\u4e00\u79cd\u6076\u6027\u8840\u6db2\u548c\u9aa8\u9ad3\u764c\u75c7\uff0c\u5bfc\u81f4\u60a3\u8005\u4f53\u5185\u529f\u80fd\u5931\u5e38\u7684\u764c\u53d8\u767d\u7ec6\u80de\u4e0d\u53d7\u63a7\u5236\u5730\u589e\u751f\u548c\u79ef\u7d2f\uff0c\u5e76\u5f71\u54cd\u6b63\u5e38\u8840\u7ec6\u80de\u7684\u751f\u6210\u3002<strong>\u636e\u4f30\u8ba1\uff0c\u7f8e\u56fd\u4eca\u5e74\u5c06\u6709\u8d85\u8fc719000\u540d\u65b0\u786e\u8bca\u60a3\u8005\uff0c\u4ee5\u53ca\u8d85\u8fc710000\u4e2aAML\u6b7b\u4ea1\u6848\u4f8b\u3002<\/strong>AML\u60a3\u8005\u76845\u5e74\u5b58\u6d3b\u7387\u53ea\u670926%\uff0c\u5728\u6240\u6709\u767d\u8840\u75c5\u7c7b\u578b\u4e2d\u662f\u6700\u4f4e\u7684\u3002<em>FLT3<\/em>\u57fa\u56e0\u7a81\u53d8\u662fAML\u60a3\u8005\u4e2d\u6700\u5e38\u89c1\u7684\u9057\u4f20\u53d8\u5f02\uff0c\u800c<em>FLT3<\/em>-ITD\u662f\u53d1\u751f\u7387\u6700\u9ad8\u7684<em>FLT3<\/em>\u57fa\u56e0\u7a81\u53d8\uff0c\u5927\u7ea61\/4\u7684AML\u60a3\u8005\u643a\u5e26\u8fd9\u79cd\u7a81\u53d8\u3002\u4e0e\u6ca1\u6709\u643a\u5e26\u8fd9\u79cd\u7a81\u53d8\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u5e26\u6709<em>FLT3<\/em>-ITD\u7a81\u53d8\u7684\u60a3\u8005\u5176\u9884\u540e\u66f4\u5dee\uff0c\u764c\u75c7\u590d\u53d1\u51e0\u7387\u66f4\u9ad8\uff0c\u4e14\u590d\u53d1\u540e\u6b7b\u4ea1\u98ce\u9669\u66f4\u5927\u3002\u8fd9\u4e9b\u60a3\u8005\u5373\u4fbf\u63a5\u53d7\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\uff08HSCT\uff09\uff0c\u6cbb\u7597\u540e\u7684\u764c\u75c7\u590d\u53d1\u51e0\u7387\u4ecd\u6bd4\u6ca1\u6709\u643a\u5e26\u8fd9\u79cd\u7a81\u53d8\u7684\u60a3\u8005\u9ad8\u3002\u76ee\u524d\uff0c\u8fd8\u672a\u6709\u9488\u5bf9\u8fd9\u4e00\u75be\u75c5\u7684\u7597\u6cd5\u83b7\u6279\u3002\u56e0\u6b64\uff0c\u672c\u6b21\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u6709\u671b\u4e3a<em>FLT3<\/em>-ITD\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(255, 255, 255);\">\u672c\u6587\u6765\u6e90\uff1a\u836f\u660e\u5eb7\u5fb7<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u672c\u6b21\u65a9\u83b7\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u7684quizartinib\u662f\u7b2c\u4e00\u4e09\u5171\u516c\u53f8\u5f00\u53d1\u7684\u53e3\u670dFLT3\u6291\u5236\u5242\u3002\u6b64\u6b21\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u7684\u6279\u51c6\u662f\u57fa\u4e8equizartinib\u7684\u5173\u952e3\u671f\u4e34\u5e8a\u8bd5\u9a8cQuANTUM-R\u7684\u826f\u597d\u7ed3\u679c\uff0cQuANTUM-R\u662f\u4e00\u9879\u5173\u952e\u7684\u5168\u7403\u6027\u3001\u5f00\u653e\u6807\u7b7e\u3001\u968f\u673a3\u671f\u7814\u7a76\uff0c<strong>\u7ed3\u679c\u663e\u793a\uff0cquizartinib\u7684\u5355\u4e00\u7597\u6cd5\u4e0e\u5316\u7597\u76f8\u6bd4\uff0c\u5ef6\u957f\u4e86<em>FLT3<\/em>-ITD r\/r AML\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\u3002<\/strong>QuANTUM-R\u663e\u793a\u51fa\u7684\u5b89\u5168\u6027\u4e0equizartinib\u7684\u4e34\u5e8a\u5f00\u53d1\u9879\u76ee\u4e00\u81f4\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 112, 192);\"><strong><span style=\"font-size: 15px;\">3. \u514d\u75ab\u7597\u6cd5\u518d\u83b7\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u6cbb\u7597\u5b50\u5bab\u5185\u819c\u764c<\/span><\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u536b\u6750\uff08Eisai\uff09\u548c\u9ed8\u6c99\u4e1c\uff08MSD\uff09\u65e5\u524d\u5ba3\u5e03\uff0c<strong>\u7f8e\u56fdFDA\u6388\u4e88\u536b\u6750\u7684\u53e3\u670d\u6fc0\u9176\u6291\u5236\u5242Lenvima\uff08lenvatinib mesylate\uff09\u548c\u9ed8\u6c99\u4e1c\u7684\u6297PD-1\u7597\u6cd5Keytruda\uff08pembrolizumab\uff09\u7ec4\u5408\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c<\/strong>\u7528\u4e8e\u6f5c\u5728\u6cbb\u7597\u7f79\u60a3\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u9ad8\uff08MSI-H\uff09\/\u7cbe\u786e\u9519\u914d\u4fee\u590d\uff08pMMR\uff09\u5b50\u5bab\u5185\u819c\u764c\uff08EC\uff09\u7684\u60a3\u8005\uff0c\u4ed6\u4eec\u5148\u524d\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u5168\u8eab\u6cbb\u7597\uff0c\u4f46\u75be\u75c5\u4f9d\u65e7\u53d1\u751f\u8fdb\u5c55\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong><\/strong><br  \/><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u51e0\u4e4e\u6240\u6709\u7684\u5b50\u5bab\u764c\u75c7\u90fd\u662f\u5b50\u5bab\u5185\u819c\u764c\u3002<strong>2018\u5e74\u9884\u8ba1\u5c06\u6709\u7ea663,230\u4f8b\u5b50\u5bab\u764c\u65b0\u53d1\u75c5\u4f8b\uff0c\u5e76\u5c06\u6709\u7ea611,350\u4eba\u6b7b\u4e8e\u5b50\u5bab\u764c\u3002<\/strong>\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u7684\u751f\u5b58\u671f\u968f\u7740\u75be\u75c5\u8fdb\u5c55\uff0c\u6709\u660e\u663e\u4e0b\u964d\u2014\u2014Ia\u671f\u5b50\u5bab\u5185\u819c\u764c\u5973\u6027\u76845\u5e74\u751f\u5b58\u7387\u4e3a88\uff05\uff0c\u800cIVb\u671f\u5973\u6027\u76845\u5e74\u751f\u5b58\u7387\u5219\u4e0b\u964d\u81f315\uff05\u3002\u5979\u4eec\u6025\u9700\u6709\u6548\u7597\u6cd5\u6765\u63a7\u5236\u75be\u75c5\uff0c\u5ef6\u957f\u751f\u547d\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">Lenvima\u52a0Keytruda\u7684\u7ec4\u5408\u7597\u6cd5\u7531\u536b\u6750\u548c\u9ed8\u6c99\u4e1c\u8054\u5408\u5f00\u53d1\u3002\u8fd9\u662fLenvima\u83b7\u5f97\u7684\u7b2c\u4e09\u4e2a\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u4e5f\u662fLenvima\u52a0Keytruda\u7ec4\u5408\u7597\u6cd5\u7ee7\u4eca\u5e741\u6708\u83b7\u5f97\u6cbb\u7597\u80be\u7ec6\u80de\u764c\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u4e4b\u540e\uff0c\u518d\u6b21\u83b7\u5f97\u7684\u7b2c\u4e8c\u4e2a\u8ba4\u5b9a\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8fd9\u6b21\u8ba4\u5b9a\u662f\u57fa\u4e8e\u4e34\u5e8a\u8bd5\u9a8cStudy 111\/KEYNOTE-146\u4e2dEC\u961f\u5217\u7684\u4e2d\u671f\u7ed3\u679c\uff0c\u5b83\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u5f00\u653e\u6807\u7b7e\u3001\u5355\u81c21b\/2\u671f\u7684\u7bee\u5b50\u8bd5\u9a8c\uff08basket trial\uff09\uff0c<strong>\u8bc4\u4f30\u4e86Lenvima\uff08\u6bcf\u592920\u6beb\u514b\uff09\u52a0Keytruda\uff08\u6bcf\u4e09\u5468\u9759\u8109\u6ce8\u5c04200\u6beb\u514b\uff09\u7ec4\u5408\u7597\u6cd5\u5bf9\u9009\u5b9a\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c<\/strong>\u5305\u62ec\u80be\u7ec6\u80de\u764c\u3001EC\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u9cde\u72b6\u7ec6\u80de\u5934\u9888\u764c\u548c\u9ed1\u8272\u7d20\u7624\u30021b\u671f\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u786e\u5b9aLenvima\u52a0Keytruda\u7ec4\u5408\u7597\u6cd5\u7684\u6700\u5927\u8010\u53d7\u5242\u91cf\u30022\u671f\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u5728\u7b2c24\u5468\u65f6\u7531\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u57fa\u4e8e\u514d\u75ab\u76f8\u5173RECIST\uff08irRECIST\uff09\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u3002\u6b21\u8981\u7ec8\u70b9\u5305\u62ecORR\u3001\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u83b7\u5f97\u5b8c\u5168\u6216\u90e8\u5206\u7f13\u89e3\u7684\u6301\u7eed\u65f6\u95f4\u3002\u76ee\u524d\uff0c2\u671f\u7814\u7a76\u90e8\u5206\u6b63\u5728\u8fdb\u884cEC\u961f\u5217\u6269\u5c55\u3002<strong>\u7ed3\u679c\u663e\u793a\uff0c\u8be5\u7ec4\u5408\u7597\u6cd5\u5728\u5b50\u5bab\u5185\u819c\u764c\u60a3\u8005\u4e2d\u5c55\u793a\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u6301\u7eed\u6d3b\u6027\u3002<\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599:<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1]<span style=\"color: rgb(178, 178, 178);font-size: 10px;white-space: pre;\">\t<\/span>Regeneron and bluebird bio Team Up to Develop Cell Therapies for Cancer.Retrieved from August 7,2018, from https:\/\/www.biospace.com\/article\/regeneron-and-bluebird-bio-team-up-to-develop-cell-therapies-for-cancer\/&nbsp;<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2]<span style=\"color: rgb(178, 178, 178);font-size: 10px;white-space: pre;\">\t<\/span>FDA Grants Breakthrough Therapy Designation to Daiichi Sankyo&#8217;s FLT3 Inhibitor Quizartinib for Relapsed\/Refractory FLT3-ITD AML. Retrieved from August 7,2018, from https:\/\/www.biospace.com\/article\/releases\/fda-grants-breakthrough-therapy-designation-to-daiichi-sankyo-s-flt3-inhibitor-quizartinib-for-relapsed-refractory-flt3-itd-aml\/<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[3]<span style=\"color: rgb(178, 178, 178);font-size: 10px;white-space: pre;\">\t<\/span>Eisai and Merck Announce FDA Grants Breakthrough Therapy Designation for LENVIMA\u00ae (lenvatinib) in Combination with KEYTRUDA\u00ae (pembrolizumab). Retrieved from August 7,2018, from&nbsp; https:\/\/www.biospace.com\/article\/releases\/eisai-and-merck-announce-fda-grants-breakthrough-therapy-designation-for-lenvima-lenvatinib-in-combination-with-keytruda-pembrolizumab\/<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);line-height: normal;\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;word-wrap: break-word !important;\">\u672c\u6587\u6765\u81ea\u836f\u660e\u5eb7\u5fb7\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"__bg_gif\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress3-1533787191.gif\" alt=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c74\u671f\uff09\" title=\"\u76d8\u70b9 | \u80bf\u7624\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c74\u671f\uff09\"  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u660e\u5eb7\u5fb7                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 1. \u518d\u751f\u5143\u4e0ebluebird bio\u8054\u624b\u5f00\u53d1\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7597\u6cd5 \u65e5\u524d\uff0c\u518d\u751f\u5143\uff08Regener [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":29204,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29203"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=29203"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29203\/revisions"}],"predecessor-version":[{"id":29212,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29203\/revisions\/29212"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/29204"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=29203"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=29203"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=29203"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}