{"id":29341,"date":"2018-08-06T01:00:00","date_gmt":"2018-08-09T04:00:48","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e7%9b%98%e7%82%b9-%e4%b8%ad%e6%9e%a2%e7%a5%9e%e7%bb%8f%e7%b3%bb%e7%bb%9f%e7%96%be%e7%97%85%e9%a2%86%e5%9f%9f%e8%bf%91%e6%9c%9f%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%ef%bc%88%e7%ac%ac59%e6%9c%9f\/"},"modified":"2018-08-09T12:00:50","modified_gmt":"2018-08-09T04:00:50","slug":"%e7%9b%98%e7%82%b9-%e4%b8%ad%e6%9e%a2%e7%a5%9e%e7%bb%8f%e7%b3%bb%e7%bb%9f%e7%96%be%e7%97%85%e9%a2%86%e5%9f%9f%e8%bf%91%e6%9c%9f%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%ef%bc%88%e7%ac%ac59%e6%9c%9f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/29341\/","title":{"rendered":"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c59\u671f\uff09"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<h1 style=\"margin-bottom: 0.8em;font-weight: inherit;font-size: 1.7em;white-space: normal;max-width: 100%;box-sizing: border-box;word-wrap: break-word;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u258e\u836f\u660e<\/span><\/strong><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 112, 192);\"><strong><span style=\"font-size: 15px;\">1. \u7f57\u6c0f\u4ea8\u5ef7\u987f\u75c5\u65b0\u7597\u6cd5\u83b7\u4f18\u5148\u836f\u54c1\u8d44\u683c<\/span><br  \/><\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7f57\u6c0f\uff08Roche\uff09\u96c6\u56e2\u8fd1\u65e5\u5ba3\u5e03\uff0c<strong>\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u6388\u4e88\u5176\u5728\u7814\u836f\u7269RG6042\uff08\u66fe\u7528\u540dIONIS-HTTRx\uff09\u4f18\u5148\u836f\u54c1\uff08PRIME\uff09\u8d44\u683c\uff0c\u7528\u4e8e\u6cbb\u7597\u4ea8\u5ef7\u987f\u75c5\uff08HD\uff09\u3002<\/strong>\u5728\u4e00\u98791\/2a\u671f\u7814\u7a76\u4e2d\uff0cRG6042\u5c55\u793a\u4e86\u51cf\u5c11\u81f4\u75c5\u6027\u7a81\u53d8\u4ea8\u5ef7\u987f\u86cb\u767d\uff08mHTT\uff09\u7684\u80fd\u529b\u3002\u4e0eFDA\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u7c7b\u4f3c\uff0cEMA\u7684\u4f18\u5148\u836f\u54c1\u8d44\u683c\u5c06\u52a0\u901f\u6f5c\u529b\u836f\u7269\u5ba1\u6279\uff0c\u4f7f\u5176\u80fd\u5c3d\u5feb\u7528\u4e8e\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533787249.jpg\" alt=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c59\u671f\uff09\" title=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c59\u671f\uff09\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">HD\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u9057\u4f20\u6027\u3001\u8fdb\u884c\u6027\u75be\u75c5\uff0c\u75c5\u56e0\u662f\u7531\u4e8e\u7f16\u7801\u4ea8\u5ef7\u987f\u86cb\u767d\uff08huntington protein\uff0cHTT\uff09\u7684\u57fa\u56e0\u51fa\u73b0\u4e09\u6838\u82f7\u9178\u5e8f\u5217CAG\u91cd\u590d\u8d85\u8fc736\u6b21\uff0c\u4f7fHTT\u4ea7\u751f\u6bd2\u6027\uff0c\u5e76\u4e14\u9010\u6e10\u635f\u5bb3\u5927\u8111\u4e2d\u7684\u795e\u7ecf\u5143\uff0c\u4ee5\u81f4\u4e25\u91cd\u5f71\u54cd\u60a3\u8005\u7684\u65e5\u5e38\u751f\u6d3b\u529f\u80fd\uff0c\u5982\u884c\u52a8\u80fd\u529b\u548c\u601d\u7ef4\u80fd\u529b\uff0c\u7ed9\u60a3\u8005\u751f\u6d3b\u5e26\u6765\u6bc1\u706d\u6027\u7684\u51b2\u51fb\u3002<strong>\u968f\u7740\u75be\u75c5\u8fdb\u5c55\uff0cHD\u60a3\u8005\u53ef\u80fd\u4f1a\u51fa\u73b0\u6027\u683c\u6539\u53d8\uff0c\u884c\u8d70\u548c\u541e\u54bd\u56f0\u96be\uff0c\u4ee5\u53ca\u4e25\u91cd\u7684\u8ba4\u77e5\u969c\u788d\u3002<\/strong>HD\u60a3\u8005\u5728\u8fd0\u52a8\u673a\u80fd\u53d1\u751f\u969c\u788d\u540e\u7684\u751f\u5b58\u671f\u5927\u7ea6\u4e3a10\u523020\u5e74\u3002HD\u662f\u53d1\u8fbe\u56fd\u5bb6\u4e2d\u6700\u5e38\u89c1\u7684\u5355\u57fa\u56e0\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff0c\u5168\u7403\u60a3\u75c5\u7387\u7ea6\u4e3a\u6bcf10\u4e07\u4eba\u4e2d3-10\u4f8b\u3002\u5728\u7f8e\u56fd\u6709\u5927\u7ea63\u4e07\u540dHD\u60a3\u8005\uff0c\u670920\u4e07\u4eba\u6709HD\u9057\u4f20\u60a3\u75c5\u98ce\u9669\u3002\u76ee\u524d\u6ca1\u6709\u5df2\u77e5\u7684HD\u7597\u6cd5\uff0c\u4e5f\u6ca1\u6709\u9488\u5bf9\u6f5c\u5728\u75c5\u56e0\u7684\u6279\u51c6\u7597\u6cd5\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533787249.jpg\" alt=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c59\u671f\uff09\" title=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c59\u671f\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u25b2\u4ea8\u5ef7\u987f\u75c5\u7684\u81f4\u75c5\u673a\u7406\uff08\u56fe\u7247\u6765\u6e90\uff1aIonis\u5b98\u7f51\uff09<\/span><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">RG6042\u662f\u7b2c\u4e8c\u4ee3\u4fee\u9970\u53cd\u4e49\u5be1\u6838\u82f7\u9178\uff08ASO\uff09\uff0c\u901a\u8fc7\u9776\u5411\u4ebaHTT mRNA\u6765\u964d\u4f4emHTT\u86cb\u767d\u7684\u5408\u6210\u548c\u8868\u8fbe\u6c34\u5e73\u3002mHTT\u88ab\u8ba4\u4e3a\u662fHD\u4e3b\u8981\u81f4\u75c5\u75c5\u56e0\uff0c\u8be5\u6bd2\u6027\u86cb\u767d\u8d28\u5728\u5927\u8111\u7684\u795e\u7ecf\u5143\u4e2d\u4ea7\u751f\u5927\u91cf\u5e9f\u7269\uff0c\u6740\u6b7b\u795e\u7ecf\u5143\u7ec6\u80de\uff0c\u5bfc\u81f4\u4e25\u91cd\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3002\u9776\u5411mHTT\u6709\u53ef\u80fd\u51cf\u7f13\u6216\u963b\u6b62\u6240\u6709HD\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55\u3002RG6042\u662f\u7f57\u6c0f\u548cIonis\u4e4b\u95f4\u5168\u9762\u6df1\u5165\u7684\u836f\u7269\u7b5b\u9009\u8ba1\u5212\u7684\u6210\u679c\uff0c\u8be5\u8ba1\u5212\u4e13\u6ce8\u4e8e\u4f18\u5316\u9776\u5411\u4ebaHTT mRNA\u7684ASO\u7684\u6709\u6548\u6027\uff0c\u7279\u5f02\u6027\u548c\u8010\u53d7\u6027\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(255, 255, 255);\">\u672c\u6587\u6765\u6e90\uff1a\u836f\u660e\u5eb7\u5fb7<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6b64\u6b21\u6388\u4e88\u7684\u4f18\u5148\u836f\u54c1\u8d44\u683c\u662f\u57fa\u4e8e\u63a2\u7d22\u60271\/2a\u671f\u7814\u7a76\u7684\u6570\u636e\u3002\u7ed3\u679c\u663e\u793amHTT\u6c34\u5e73\u663e\u8457\u51cf\u5c11\u3002\u5728\u4e24\u79cd\u6700\u9ad8RG6042\u5242\u91cf\u4e0b\u6cbb\u75973\u4e2a\u6708\uff0c\u6210\u5e74\u60a3\u8005\u8111\u810a\u6db2\uff08CSF\uff09\u4e2d\u7684\u6807\u5fd7\u6027HD\u86cb\u767d\u5e73\u5747\u51cf\u5c1140%\uff08\u6700\u9ad8\u8fbe60%\uff09\u3002\u5728\u7814\u7a76\u7684\u6700\u540e\u4e00\u6b21\u6d4b\u91cf\u4e2d\uff0c\u7ea6\u670970%\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005CSF\u4e2d\u7684mHTT\u6c34\u5e73\u4ecd\u5728\u4e0b\u964d\u3002\u6b64\u5916\uff0cRG6042\u8010\u53d7\u6027\u826f\u597d\u3002\u6309\u8ba1\u5212\uff0c\u7f57\u6c0f\u5c06\u5f00\u5c55\u5173\u952e3\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5728\u8f83\u5927\u60a3\u8005\u7fa4\u4f53\u4e2d\u8bc4\u4f30RG6042\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 112, 192);\"><strong><span style=\"font-size: 15px;\">2. Denali\u516c\u5e03\u6700\u65b0\u8fdb\u5c55\uff0c\u6709\u671b\u9020\u798f\u5e15\u91d1\u68ee\u75c5\u60a3\u8005<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u65e5\u524d\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4ea7\u54c1\u7ec4\u5408\u7684\u751f\u7269\u533b\u836f\u516c\u53f8Denali Therapeutics\u5ba3\u5e03\uff0c\u5176LRRK2\u5c0f\u5206\u5b50\u6291\u5236\u5242\u65b0\u836fDNL201\u53d6\u5f971\u671f\u4e34\u5e8a\u7814\u7a76\u79ef\u6781\u6210\u679c\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 15px;\"><img class=\"\"       style=\"color: rgb(51, 51, 51);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress0-1533787249.jpeg\" alt=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c59\u671f\uff09\" title=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c59\u671f\uff09\"  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5e15\u91d1\u68ee\u75c5\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u5728\u5168\u4e16\u754c\u8303\u56f4\u5185\u5f71\u54cd\u4e86\u7ea61000\u4e07\u4eba\u3002\u867d\u7136\u75c5\u56e0\u5c1a\u672a\u5b8c\u5168\u9610\u660e\uff0c\u4f462004\u5e74\u53d1\u73b0<em>LRRK2<\/em>\u57fa\u56e0\u7a81\u53d8\u4f1a\u63d0\u9ad8\u5e15\u91d1\u68ee\u75c5\u7684\u53d1\u75c5\u98ce\u9669\u3002\u5b83\u4e5f\u662f\u6eb6\u9176\u4f53\u529f\u80fd\u969c\u788d\u7684\u4e3b\u8981\u9a71\u52a8\u56e0\u7d20\uff0c\u4f1a\u5bfc\u81f4\u8def\u6613\u4f53\u86cb\u767d\u805a\u96c6\u4f53\uff08Lewy body protein aggregates\uff09\u7684\u5f62\u6210\u548c\u795e\u7ecf\u53d8\u6027\u3002\u8fd1\u6765\u4e5f\u6709\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u652f\u6301LRRK2\u6291\u5236\u5242\u5728\u6563\u53d1\u6027\u5e15\u91d1\u68ee\u75c5\u4eba\u7fa4\u4e2d\u8d77\u4f5c\u7528\uff0c\u4e0d\u4ec5\u4ec5\u5c40\u9650\u4e8e\u4e0e<em>LRRK2<\/em>\u9057\u4f20\u7a81\u53d8\u76f8\u5173\u7684\u5e15\u91d1\u68ee\u75c5\u4e2d\u3002\u901a\u8fc7\u6291\u5236LRRK2\uff0c\u6709\u671b\u6062\u590d\u53d7\u635f\u7684\u6eb6\u9176\u4f53\u529f\u80fd\uff0c\u4ece\u800c\u6539\u53d8\u5177\u6709<em>LRRK2<\/em>\u7a81\u53d8\u53ca\u6563\u53d1\u6027\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728\u8fd9\u8d77\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u53e3\u670d\u5242\u91cf\u76841\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u6709\u8d85\u8fc7100\u540d\u5065\u5eb7\u53d7\u8bd5\u8005\u63a5\u53d7\u4e86\u5355\u6b21\u6216\u591a\u6b21\u9012\u589e\u5242\u91cf\u6216\u5b89\u6170\u5242\u6cbb\u7597\u3002\u7ed3\u679c\u663e\u793a\uff0cDNL201\u5b9e\u73b0\u4e86\u5176\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u836f\u6548\u5b66\u76ee\u6807\u3002DNL201\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u5728\u8fbe\u5230\u9ad8\u6c34\u5e73\u8111\u810a\u6db2\uff08CSF\uff09\u66b4\u9732\u7684\u5242\u91cf\u4e0b\u6ca1\u6709\u4ea7\u751f\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u7528\u4e24\u79cd\u8840\u6db2LRRK2\u6d3b\u6027\u751f\u7269\u6807\u5fd7\u7269\u6d4b\u91cf\u65f6\u6709\u7a33\u5065\u7684\u9776\u6807\u53c2\u4e0e\uff0c\u4e14\u5bf9\u6eb6\u9176\u4f53\u529f\u80fd\u7684\u751f\u7269\u6807\u5fd7\u7269\u6709\u5f71\u54cd\u3002<strong>\u57fa\u4e8e\u8fd9\u4e9b\u4e34\u5e8a\u6570\u636e\uff0cDenali\u6253\u7b97\u5728\u4eca\u5e74\u5e74\u5e95\u4e4b\u524d\u5c06DNL201\u63a8\u8fdb\u52301b\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u4e0d\u7ba1\u60a3\u8005\u662f\u5426\u5177\u6709<em>LRRK2<\/em>\u7a81\u53d8\u3002<\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 112, 192);\"><strong><span style=\"font-size: 15px;\">3. \u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\uff0c\u9996\u6b3e\u957f\u6548\u6ce8\u5c04\u5242\u83b7\u6279<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">\u8fd1\u65e5\uff0cIndivior\u5ba3\u5e03\u7f8e\u56fdFDA\u6279\u51c6PERSERIS\u2122\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u7f79\u60a3\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u6210\u4eba\u60a3\u8005\u3002<\/span><\/strong><span style=\"font-size: 15px;\">\u8fd9\u662f\u9996\u4e2a\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u5229\u57f9\u916e\u957f\u6548\u6ce8\u5c04\u5242\uff08LAI\uff09\u3002\u5728\u4e0d\u4f7f\u7528\u8d1f\u8377\u5242\u91cf\u6216\u4efb\u4f55\u53e3\u670d\u5229\u57f9\u916e\u7684\u60c5\u51b5\u4e0b\uff0c\u9996\u6b21\u6ce8\u5c04PERSERIS\u2122\u5373\u53ef\u8fbe\u5230\u4e34\u5e8a\u76f8\u5173\u6c34\u5e73\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7cbe\u795e\u5206\u88c2\u75c7\u662f\u4e00\u79cd\u6162\u6027\u3001\u7834\u574f\u6027\u3001\u4e14\u7ecf\u5e38\u81f4\u6b8b\u7684\u7cbe\u795e\u75be\u75c5\uff0c\u4f1a\u5f71\u54cd\u60a3\u6709\u8fd9\u79cd\u75be\u75c5\u7684\u60a3\u8005\u3001\u5bb6\u4eba\u548c\u62a4\u7406\u4eba\u5458\u7684\u751f\u6d3b\u3002\u7f79\u60a3\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u4eba\u9762\u4e34\u7740\u590d\u6742\u7684\u5883\u51b5\uff0c\u53ef\u80fd\u906d\u53d7\u65e0\u77e5\u3001\u51b7\u6f20\u548c\u803b\u8fb1\u7684\u963b\u788d\u3002\u6709\u6548\u7684\u836f\u7269\u6709\u53ef\u80fd\u51cf\u5c11\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u7684\u803b\u8fb1\u611f\uff0c\u5e76\u6269\u5927\u4ed6\u4eec\u53ef\u4ee5\u83b7\u5f97\u5faa\u8bc1\u6cbb\u7597\u7684\u673a\u4f1a\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">PERSERIS\u2122\u542b\u6709\u5229\u57f9\u916e\uff0c\u8fd9\u662f\u4e00\u79cd\u6210\u719f\u7684\u7528\u4e8e\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/span><\/strong><span style=\"font-size: 15px;\">PERSERIS\u2122\u4f7f\u7528\u7f13\u91ca\u9012\u9001\u7cfb\u7edf\u5f62\u6210\u76ae\u4e0b\u8d2e\u5b58\uff0c\u7136\u540e\u5728\u4e00\u4e2a\u6708\u5185\u63d0\u4f9b\u6301\u7eed\u6c34\u5e73\u7684\u5229\u57f9\u916e\u3002\u5229\u57f9\u916e\u5728\u8840\u6db2\u4e2d\u7684\u521d\u59cb\u5cf0\u503c\u53d1\u751f\u5728\u7ed9\u836f\u540e4\u81f36\u5c0f\u65f6\u5185\uff0c\u6765\u81ea\u76ae\u4e0b\u8d2e\u5b58\u5f62\u6210\u8fc7\u7a0b\u4e2d\u836f\u7269\u7684\u521d\u6b21\u91ca\u653e\u3002\u7531\u4e8e\u75be\u75c5\u7684\u590d\u6742\u6027\uff0c\u6cbb\u7597\u4f9d\u4ece\u6027\u662f\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u4e3b\u8981\u6311\u6218\u3002PERSERIS\u2122\u53ef\u4ee5\u63d0\u4f9b\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u836f\u7269\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u6709\u671b\u6539\u5584\u4f9d\u4ece\u6027\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">PERSERIS\u2122\u7684\u7597\u6548\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u5230\u8bc1\u5b9e\u3002\u8fd9\u9879\u4e3a\u671f8\u5468\u7684\u5173\u952e3\u671f\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76\u5305\u542b\u4e86354\u540d\u60a3\u8005\uff0c\u63a5\u53d7PERSERIS\u2122\u7684\u60a3\u8005\u5728\u7b2c57\u5929\u7684\u9633\u6027\u548c\u9634\u6027\u75c7\u72b6\u91cf\u8868\uff08PANSS\uff09\u603b\u5206\u5f97\u5230\u6539\u5584\uff0c\u62b5\u8fbe\u4e86\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\u3002\u4e34\u5e8a\u603b\u4f53\u5370\u8c61\u91cf\u8868-\u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6\uff08CGI-S\uff09\u4e5f\u5728\u7b2c57\u5929\u8fbe\u5230\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u6539\u5584\u3002\u6b64\u5916\uff0c\u5728814\u540d\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u4e2d\u8bc4\u4f30\u7684\u5b89\u5168\u6027\u7ed3\u679c\u8868\u660e\uff0cPERSERIS\u2122\u7684\u5b89\u5168\u6027\u4e0e\u53e3\u670d\u5229\u57f9\u916e\u7684\u5df2\u77e5\u5b89\u5168\u6027\u4e00\u81f4\u3002&nbsp;<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1] Roche gets some regulatory love for its breakthrough quest on a PhIII Huntington\u2019s drug<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2] Denali Therapeutics Announces Positive Clinical Results From LRRK2 Inhibitor Program for Parkinson\u2019s Disease<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[3] FDA Approves PERSERIS\u2122 (risperidone) for Extended-Release Injectable Suspension for the Treatment of Schizophrenia in Adults<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);line-height: normal;\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;word-wrap: break-word !important;\">\u672c\u6587\u6765\u81ea\u836f\u660e\u5eb7\u5fb7\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"__bg_gif\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533787249.gif\" alt=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c59\u671f\uff09\" title=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c59\u671f\uff09\"  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u660e\u5eb7\u5fb7                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 1. \u7f57\u6c0f\u4ea8\u5ef7\u987f\u75c5\u65b0\u7597\u6cd5\u83b7\u4f18\u5148\u836f\u54c1\u8d44\u683c 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[&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":29342,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29341"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=29341"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29341\/revisions"}],"predecessor-version":[{"id":29351,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29341\/revisions\/29351"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/29342"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=29341"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=29341"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=29341"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}