{"id":29359,"date":"2018-08-04T01:00:00","date_gmt":"2018-08-09T04:00:56","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%e7%96%97%e6%b3%955%e5%b9%b4%e5%86%85%e5%b0%86%e6%9c%89%e9%87%8d%e5%a4%a7%e7%a0%94%e7%a9%b6%e7%aa%81%e7%a0%b4%ef%bc%9f-%e4%b8%93%e8%ae%bf\/"},"modified":"2018-08-09T12:00:58","modified_gmt":"2018-08-09T04:00:58","slug":"%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%e7%96%97%e6%b3%955%e5%b9%b4%e5%86%85%e5%b0%86%e6%9c%89%e9%87%8d%e5%a4%a7%e7%a0%94%e7%a9%b6%e7%aa%81%e7%a0%b4%ef%bc%9f-%e4%b8%93%e8%ae%bf","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/29359\/","title":{"rendered":"\u5e15\u91d1\u68ee\u75c5\u7597\u6cd55\u5e74\u5185\u5c06\u6709\u91cd\u5927\u7814\u7a76\u7a81\u7834\uff1f | \u4e13\u8bbf"},"content":{"rendered":"
\n

\u258e\u836f\u660e<\/span><\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n


<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n

<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n

\u7f16\u8005\u6309\uff1a<\/span><\/strong>Michael J. Fox\u5e15\u91d1\u68ee\u7814\u7a76\u57fa\u91d1\u4f1a\uff08MJFF\uff09\u6295\u5165\u8fd190%\u7684\u5f00\u652f\uff0c\u7528\u4e8e\u5f00\u53d1\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u65b9\u6cd5\u3002\u81ea2000\u5e74\u6210\u7acb\u4ee5\u6765\uff0c\u5b83\u603b\u8ba1\u6295\u5165\u8d85\u8fc78\u4ebf\u7f8e\u5143\uff0c2017\u5e74\u5c31\u6295\u51651\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n

MJFF\u9996\u5e2d\u6267\u884c\u5b98Todd Sherer\u535a\u58eb\u8bf4\uff0c\u8be5\u7ec4\u7ec7\u201c\u662f\u4e16\u754c\u4e0a\u6700\u5927\u7684\u81f4\u529b\u4e8e\u5e15\u91d1\u68ee\u75c5\u7814\u7a76\u7684\u975e\u8425\u5229\u6027\u8d44\u52a9\u8005\u201d\uff0c\u4ed6\u9884\u8ba1\u672a\u6765\u4e94\u5e74\u5728\u5f00\u53d1\u5e15\u91d1\u68ee\u75c5\u7597\u6cd5\u65b9\u9762\u5c06\u53d6\u5f97\u91cd\u5927\u8fdb\u5c55\u201c\u4ee5\u51cf\u7f13\u6216\u963b\u6b62\u75be\u75c5\u8fdb\u5c55\u201d\u3002<\/span><\/p>\n

\u4e8b\u5b9e\u4e0a\uff0cMJFF\u5728\u7814\u7a76\u5e15\u91d1\u68ee\u75c5\u7684\u7597\u6cd5\u65b9\u9762\u5df2\u7ecf\u53d6\u5f97\u4e86\u5b9e\u8d28\u6027\u8fdb\u5c55\u3002Sherer\u535a\u58eb\u8bf4\uff0c\u5e15\u91d1\u68ee\u75c5\u7684\u75c5\u56e0\u88ab\u8ba4\u4e3a\u662f\u9057\u4f20\u503e\u5411\u548c\u73af\u5883\u89e6\u53d1\u56e0\u7d20\u7684\u7efc\u5408\u4f5c\u7528\uff0c\u7814\u7a76\u63ed\u793a\u4e86\u8be5\u75c5\u4e0e\u5176\u4ed6\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u4e4b\u95f4\u7684\u8054\u7cfb\u3002\u4ed6\u8865\u5145\u8bf4\uff1a\u201c\u6211\u4eec\u8fd8\u53d1\u73b0\u5e15\u91d1\u68ee\u548c\u975e\u8111\u90e8\u75be\u75c5\uff08\u5982\u6208\u8c22\u75c5\u548c\u514b\u7f57\u6069\u75c5\uff09\u4e4b\u95f4\u7684\u57fa\u56e0\u76f8\u4f3c\u6027\uff0c\u8fd9\u53ef\u80fd\u6709\u52a9\u4e8e\u6211\u4eec\u66f4\u597d\u5730\u7406\u89e3\u548c\u6cbb\u7597\u5404\u79cd\u75be\u75c5\u3002\u201d\u6839\u636e\u5168\u7403\u75be\u75c5\u8d1f\u62c5\u7814\u7a76\uff08Global Burden of Disease Study\uff09\uff0c\u5728\u5317\u7f8e\u6709\u8d85\u8fc7100\u4e07\u4eba\u3001\u5728\u5168\u7403\u6709600\u4e07\u4eba\u53d7\u5230\u5e15\u91d1\u68ee\u75c5\u7684\u5f71\u54cd\u3002\u5728\u7f8e\u56fd\uff0c\u6bcf\u5e74\u67096\u4e07\u4f8b\u65b0\u75c5\u4f8b\u88ab\u786e\u8bca\u3002<\/span><\/p>\n

Sherer\u535a\u58eb\u4e8e2011\u5e74\u5f00\u59cb\u62c5\u4efbMJFF\u7684\u9996\u5e2d\u6267\u884c\u5b98\u3002Sherer\u535a\u58eb\u662f\u5168\u4e16\u754c\u516c\u8ba4\u7684\u5e15\u91d1\u68ee\u75c5\u7597\u6cd5\u4e13\u5bb6\uff0c\u4ed6\u662f\u5f17\u5409\u5c3c\u4e9a\u5927\u5b66\uff08University of Virginia\uff09\u795e\u7ecf\u79d1\u5b66\u4e13\u4e1a\u7684\u535a\u58eb\uff0c\u5e76\u62e5\u6709\u675c\u514b\u5927\u5b66\uff08Duke University\uff09\u5fc3\u7406\u5b66\u5b66\u58eb\u5b66\u4f4d\u3002<\/span><\/p>\n

\u4f5c\u4e3a\u836f\u660e\u5eb7\u5fb7\u5e15\u91d1\u68ee\u75c5\u7cfb\u5217\u8bbf\u8c08\u7684\u4e00\u90e8\u5206\uff0cSherer\u535a\u58eb\u4e0e\u6211\u4eec\u63a2\u8ba8\u4e86\u5e15\u91d1\u68ee\u75c5\u7814\u7a76\u7684\u79d1\u5b66\u8fdb\u5c55\u3001\u836f\u7269\u5f00\u53d1\u8005\u6240\u9762\u4e34\u7684\u6311\u6218\u4ee5\u53ca\u5728\u5bfb\u627e\u6cbb\u6108\u7597\u6cd5\u65b9\u9762\u6240\u53d6\u5f97\u7684\u8fdb\u5c55\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u5e15\u91d1\u68ee\u75c5\u7597\u6cd55\u5e74\u5185\u5c06\u6709\u91cd\u5927\u7814\u7a76\u7a81\u7834\uff1f<\/p>\n

<\/span>
<\/p>\n

\n
\n
\n
\n
\n
\n
\n

\u836f\u660e\u5eb7\u5fb7\uff1a\u5e15\u91d1\u68ee\u75c5\u662f\u7531\u57fa\u56e0\u5f02\u5e38\u8fd8\u662f\u7531\u73af\u5883\u56e0\u7d20\u5f15\u8d77\u7684\uff1f\u6216\u662f\u4e24\u8005\u7efc\u5408\u5f15\u8d77\u7684\uff1f<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

Todd Sherer\u535a\u58eb\uff1a<\/span><\/strong>20\u591a\u5e74\u524d\uff0c\u79d1\u5b66\u5bb6\u4eec\u8ba4\u4e3a\u5e15\u91d1\u68ee\u75c5\u6ca1\u6709\u9057\u4f20\u6210\u5206\u3002\u7136\u800c\uff0c\u5728\u8fc7\u53bb\u768420\u5e74\u4e2d\uff0c\u4eba\u4eec\u5df2\u7ecf\u610f\u8bc6\u5230\u9057\u4f20\u5b66\u53ca\u5176\u4e0e\u73af\u5883\u548c\u751f\u6d3b\u65b9\u5f0f\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u53ef\u80fd\u5bfc\u81f4\u5e15\u91d1\u68ee\u75c5\u7684\u98ce\u9669\u3002<\/strong>\u5728\u5927\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u9057\u4f20\u503e\u5411\u548c\u73af\u5883\u56e0\u7d20\u53ef\u80fd\u5bfc\u81f4\u5e15\u91d1\u68ee\u75c5\u3002<\/span><\/p>\n


<\/p>\n

\n
\n
\n
\n
\n
\n
\n

\u836f\u660e\u5eb7\u5fb7\uff1a\u60a8\u5982\u4f55\u63cf\u8ff0\u5e15\u91d1\u68ee\u75c5\u7814\u7a76\u7684\u6f14\u53d8\uff1f<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

Todd Sherer\u535a\u58eb\uff1a<\/span><\/strong>\u5e15\u91d1\u68ee\u75c5\u7684\u7814\u7a76\u5728\u8fc7\u53bb20\u5e74\u91cc\u7ecf\u5386\u4e86\u4e00\u573a\u9057\u4f20\u5b66\u9769\u547d\u2014\u2014\u5f00\u542f\u4e86\u5bf9\u75be\u75c5\u98ce\u9669\u3001\u53d1\u75c5\u548c\u8fdb\u5c55\u7684\u65b0\u8ba4\u8bc6\uff0c\u5e76\u6307\u5411\u4e86\u79d1\u5b66\u5bb6\u4eec\u73b0\u5728\u575a\u6301\u4e0d\u61c8\u8ffd\u6c42\u7684\u6cbb\u7597\u9776\u70b9\u548c\u5019\u9009\u751f\u7269\u6807\u5fd7\u7269\u3002\u6b64\u5916\uff0c\u4eba\u4eec\u5bf9\u8fd9\u79cd\u75be\u75c5\u7684\u8ba4\u8bc6\u8d8a\u6765\u8d8a\u591a\uff1a\u5e15\u91d1\u68ee\u75c5\u4e0d\u4ec5\u4ec5\u662f\u4e00\u79cd\u8fd0\u52a8\u969c\u788d\u3002<\/strong>\u79d1\u5b66\u5bb6\u548c\u4e34\u5e8a\u533b\u751f\u73b0\u5728\u8ba4\u8bc6\u5230\u8be5\u75be\u75c5\u7684\u8bb8\u591a\u975e\u8fd0\u52a8\u56e0\u7d20\uff0c\u4f8b\u5982\u60c5\u7eea\u969c\u788d\u3001\u8ba4\u77e5\u969c\u788d\u548c\u81ea\u4e3b\u795e\u7ecf\u529f\u80fd\u969c\u788d\u7b49\uff0c\u5e76\u6b63\u5728\u5f00\u53d1\u591a\u5df4\u80fa\u7cfb\u7edf\u4ee5\u5916\u7684\u9776\u5411\u7597\u6cd5\u3002<\/span><\/p>\n


<\/p>\n

\n
\n
\n
\n
\n
\n
\n

\u836f\u660e\u5eb7\u5fb7\uff1a\u7814\u7a76\u4eba\u5458\u6240\u4e86\u89e3\u7684\u5e15\u91d1\u68ee\u75c5\u7684\u75c5\u56e0\u662f\u4ec0\u4e48\uff1f\u662f\u5426\u4f1a\u5bf9\u5176\u4ed6\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u6709\u5f71\u54cd\uff1f<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

Todd Sherer\u535a\u58eb\uff1a<\/span><\/strong>\u4e00\u4e9b\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u5982\u8def\u6613\u4f53\u5931\u667a\u75c7\u548c\u591a\u7cfb\u7edf\u840e\u7f29\u4e0e\u5e15\u91d1\u68ee\u75c5\u7684\u6807\u5fd7\u6027\u75c5\u7406\u76f8\u540c\u2014\u2014\u86cb\u767d\u8d28\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u7684\u79ef\u7d2f\u3002\u5173\u4e8e\u5bfc\u81f4\u8fd9\u79cd\u86cb\u767d\u79ef\u805a\u53ca\u5176\u4f20\u64ad\u7684\u751f\u7269\u5b66\u8fc7\u7a0b\u7684\u7814\u7a76\u5c06\u4e3a\u7a81\u89e6\u6838\u86cb\u767d\u75c5\u60a3\u8005\u7684\u6cbb\u7597\u63d0\u4f9b\u4fe1\u606f\u3002\u6211\u4eec\u8fd8\u53d1\u73b0\u5e15\u91d1\u68ee\u75c5\u548c\u975e\u8111\u90e8\u75be\u75c5\uff08\u5982\u6208\u8c22\u75c5\u548c\u514b\u7f57\u6069\u75c5\uff09\u4e4b\u95f4\u7684\u57fa\u56e0\u76f8\u4f3c\u6027\uff0c\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u66f4\u597d\u5730\u7406\u89e3\u548c\u6cbb\u7597\u5404\u79cd\u75be\u75c5\u3002<\/span><\/p>\n


<\/p>\n

\n
\n
\n
\n
\n
\n
\n

\u836f\u660e\u5eb7\u5fb7\uff1a\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u7684BRAIN\u8ba1\u5212\u5bf9\u5e15\u91d1\u68ee\u75c5\u7814\u7a76\u6709\u5f71\u54cd\u5417\uff1f<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/span><\/strong><\/p>\n

Todd Sherer\u535a\u58eb\uff1a<\/span><\/strong>\u56f4\u7ed5\u5927\u8111\u529f\u80fd\u548c\u75be\u75c5\u8fd8\u6709\u5f88\u591a\u95ee\u9898\u9700\u8981\u7814\u7a76\u3002NIH\u7684BRAIN\u8ba1\u5212\u5df2\u5c06\u5173\u952e\u7684\u7814\u7a76\u8d44\u91d1\u3001\u6ce8\u610f\u529b\u548c\u4e13\u4e1a\u77e5\u8bc6\u5f15\u5bfc\u81f3\u7406\u89e3\u8fd9\u4e00\u590d\u6742\u5668\u5b98\u5e76\u6cbb\u7597\u5176\u529f\u80fd\u6027\u969c\u788d\u3002<\/span>
<\/p>\n


<\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\n

\u836f\u660e\u5eb7\u5fb7\uff1aMJFF\u662f\u5982\u4f55\u652f\u6301\u5e15\u91d1\u68ee\u75c5\u7814\u7a76\u548c\u836f\u7269\u5f00\u53d1\u7684\uff1f<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/span><\/p>\n

Todd Sherer\u535a\u58eb\uff1a<\/span><\/strong>MJFF\u662f\u5168\u7403\u6700\u5927\u7684\u5e15\u91d1\u68ee\u75c5\u7814\u7a76\u975e\u8425\u5229\u6027\u8d44\u52a9\u8005\u3002\u6211\u4eec\u6bcf\u5e74\u4e24\u6b21\u516c\u5f00\u547c\u5401\u7533\u8bf7\u8d44\u52a9\u8ba1\u5212\uff0c\u4ee5\u63a8\u8fdb\u6211\u4eec\u7684\u7814\u7a76\u91cd\u70b9\u3002<\/span><\/p>\n

\n

\u9664\u4e86\u7ed9\u4e88\u8d44\u91d1\uff0c\u6211\u4eec\u8fd8\u5efa\u8bbe\u57fa\u7840\u8bbe\u65bd\uff0c\u63d0\u4f9b\u8d44\u6e90\u5e2e\u52a9\u79d1\u5b66\u5bb6\u4eec\u52a0\u901f\u5f00\u53d1\u4ed6\u4eec\u7684\u9879\u76ee\u3002\u6211\u4eec\u7684\u57fa\u91d1\u4f1a\u5f00\u53d1\u4e86\u4e00\u4e2a\u5e7f\u6cdb\u7684\u7814\u7a76\u5de5\u5177\u76ee\u5f55\uff0c\u5982\u5316\u9a8c\u3001\u6297\u4f53\u3001\u548c\u6a21\u578b\uff0c\u8fd9\u4e9b\u5de5\u5177\u53ef\u8fc5\u901f\u6309\u6210\u672c\u4ef7\u63d0\u4f9b\u7ed9\u5b66\u672f\u754c\u548c\u5de5\u4e1a\u754c\u7684\u7814\u7a76\u4eba\u5458\u3002<\/span>
<\/p>\n


<\/p>\n

\u79d1\u5b66\u754c\uff08\u5305\u62ec\u5de5\u4e1a\u754c\u548c\u5b66\u672f\u754c\uff09\u7684\u5176\u4ed6\u8d44\u6e90\u5305\u62ec\u5f00\u653e\u83b7\u53d6\u975e\u7279\u5b9a\u7684\u7814\u7a76\u6570\u636e\u3001\u53ef\u8bf7\u6c42\u63d0\u4f9b\u7684\u751f\u7269\u6837\u672c\u3001\u4ee5\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u548c\u4fdd\u7559\u652f\u6301\u3002<\/span><\/p>\n


<\/p>\n

\n
\n
\n
\n
\n
\n
\n

\u836f\u660e\u5eb7\u5fb7\uff1a\u5f00\u53d1\u5e15\u91d1\u68ee\u75c5\u7597\u6cd5\u7684\u6700\u4f73\u7b56\u7565\u662f\u4ec0\u4e48\uff1f<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/strong><\/span><\/p>\n

Todd Sherer\u535a\u58eb\uff1a<\/strong><\/span>\u5e15\u91d1\u68ee\u75c5\u836f\u7269\u7814\u53d1\u7684\u4e00\u4e2a\u65b0\u5174\u9886\u57df\u662f\u7cbe\u51c6\u533b\u7597\u3002\u4f8b\u5982\uff0c\u6211\u4eec\u53ef\u80fd\u9488\u5bf9\u4eba\u7fa4\u4e2d\u5b58\u5728\u7684\u3001\u4e0e\u57fa\u56e0\u7a81\u53d8\u76f8\u5173\u7684\u529f\u80fd\u969c\u788d\u8fdb\u884c\u6cbb\u7597\u3002\u8fd9\u79cd\u57fa\u4e8e\u751f\u7269\u5b66\u548c\u75c5\u56e0\u5b66\u6307\u5bfc\u6cbb\u7597\u7684\u7b56\u7565\uff0c\u5c06\u6709\u671b\u5728\u51cf\u7f13\u548c\u963b\u6b62\u75be\u75c5\u8fdb\u5c55\u4e2d\u53d6\u5f97\u6210\u529f\u3002<\/span>
<\/p>\n

\u672c\u6587\u6765\u6e90\uff1a\u836f\u660e\u5eb7\u5fb7<\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\n

\u836f\u660e\u5eb7\u5fb7\uff1a\u5728\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u8fc7\u7a0b\u4e2d\u9047\u5230\u54ea\u4e9b\u6311\u6218\uff1f<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/span><\/p>\n

Todd Sherer\u535a\u58eb\uff1a<\/span><\/strong>\u5e15\u91d1\u68ee\u75c5\u7684\u4e34\u5e8a\u548c\u751f\u7269\u53d8\u5f02\u6027\u5bf9\u836f\u7269\u7814\u53d1\u5177\u6709\u6311\u6218\u6027\u3002<\/span><\/strong>\u6211\u4eec\u9700\u8981\u5ba2\u89c2\u7684\u3001\u9009\u62e9\u6027\u7684\u751f\u7269\u6807\u5fd7\u7269\u6d4b\u8bd5\u6765\u9884\u6d4b\u3001\u8bca\u65ad\u548c\u76d1\u6d4b\u5e15\u91d1\u68ee\u75c5\uff0c\u5e76\u6d4b\u8bd5\u6cbb\u7597\u5e72\u9884\u63aa\u65bd\u7684\u5f71\u54cd\u3002MJFF\u8d5e\u52a9\u201c\u5e15\u91d1\u68ee\u75c5\u8fdb\u5c55\u6807\u5fd7\u7269\u9879\u76ee\u201d\uff08PPMI\uff09\uff0c\u8fd9\u662f\u4e00\u9879\u5927\u89c4\u6a21\u7684\u7eb5\u5411\u7814\u7a76\uff0c\u65e8\u5728\u9274\u5b9a\u548c\u9a8c\u8bc1\u75be\u75c5\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002\u7814\u7a76\u6570\u636e\u5411\u5de5\u4e1a\u754c\u548c\u5b66\u672f\u754c\u7684\u6240\u6709\u7b26\u5408\u8d44\u683c\u7684\u7814\u7a76\u4eba\u5458\u5f00\u653e\uff0c<\/strong>\u5df2\u88ab\u79d1\u5b66\u754c\u4e0b\u8f7d\u8d85\u8fc7150\u4e07\u6b21\uff0c\u4ee5\u505a\u8fdb\u4e00\u6b65\u7684\u5206\u6790\u3002<\/strong><\/span>
<\/p>\n


<\/p>\n

\n
\n
\n
\n
\n
\n
\n

\u836f\u660e\u5eb7\u5fb7\uff1a\u9700\u8981\u54ea\u4e9b\u79d1\u5b66\u7a81\u7834\u624d\u80fd\u66f4\u597d\u5730\u4e86\u89e3\u5e15\u91d1\u68ee\u75c5\u7684\u53d1\u75c5\u539f\u56e0\u548c\u8fdb\u5c55\uff1f<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

Todd Sherer\u535a\u58eb\uff1a<\/span><\/strong>MJFF\u8d5e\u52a9\u7684PPMI\u7b49\u5927\u89c4\u6a21\u89c2\u5bdf\u6027\u7814\u7a76\u7684\u6269\u5c55\u6b63\u5728\u5e2e\u52a9\u5efa\u7acb\u79d1\u5b66\u7a81\u7834\u7684\u57fa\u7840\u8bbe\u65bd\u3002PPMI\u6b63\u5728\u6536\u96c6\u591a\u5e74\u7684\u60a3\u8005\u7efc\u5408\u6570\u636e\uff0c\u5305\u62ec\u6765\u81ea\u53ef\u7a7f\u6234\u8bbe\u5907\u548c\u79fb\u52a8\u8bbe\u5907\u7684\u4e34\u5e8a\u8bc4\u4f30\u3001\u6210\u50cf\u3001\u6d41\u4f53\u548c\u4fe1\u606f\u3002\u6b64\u5916\uff0c\u6280\u672f\u6b63\u5728\u5b9e\u73b0\u6df1\u5165\u7684\u7ec6\u80de\u5206\u6790\u3002\u73b0\u5728\u7684\u6311\u6218\u5728\u4e8e\uff0c\u5c06\u8fd9\u4e9b\u6570\u636e\u8f6c\u5316\u4e3a\u53ef\u6307\u5411\u5e15\u91d1\u68ee\u75c5\u56e0\u548c\u751f\u7269\u6807\u5fd7\u7269\u7684\u53ef\u64cd\u4f5c\u6d1e\u89c1\u3002<\/strong><\/span><\/p>\n


<\/p>\n

\n
\n
\n
\n
\n
\n
\n

\u836f\u660e\u5eb7\u5fb7\uff1a\u672a\u6765\u4e94\u5e74\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u5c06\u5982\u4f55\u6f14\u53d8\uff1f<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

Todd Sherer\u535a\u58eb\uff1a<\/span><\/strong>\u4e00\u4e9b\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u75c7\u72b6\u7684\u65b0\u7597\u6cd5\u5df2\u4e34\u8fd1\u4e0a\u5e02\u3002\u7f8e\u56fdFDA\u76ee\u524d\u6b63\u5728\u5ba1\u67e5\u4e00\u79cd\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u6d41\u53e3\u6c34\u7684\u65b0\u836f\u7533\u8bf7\u548c\u4e24\u79cd\u7597\u6cd5\uff0c\u4ee5\u4fbf\u5728\u6807\u51c6\u7597\u6cd5\u5931\u6548\u65f6\u8fc5\u901f\u7f13\u89e3\u8fd0\u52a8\u75c7\u72b6\u3002<\/span><\/p>\n


<\/p>\n

\u6b64\u5916\uff0c\u8bd5\u9a8c\u6b63\u5728\u6d4b\u8bd5\u9488\u5bf9\u5e15\u91d1\u68ee\u75c5\u9057\u4f20\u9776\u70b9\u7684\u7597\u6cd5\uff0c\u5982\u03b1-\u7a81\u89e6\u6838\u86cb\u767d\u3001GBA\uff08\u8461\u7cd6\u795e\u7ecf\u9170\u80fa\u9176\u03b2\uff09\u548cLRRK2\uff08\u5bcc\u542b\u4eae\u6c28\u9178\u91cd\u590d\u6fc0\u91762\uff09\uff0c\u6709\u53ef\u80fd\u51cf\u7f13\u6216\u963b\u6b62\u75be\u75c5\u8fdb\u5c55\u3002\u867d\u7136\u6211\u4eec\u4ecd\u7136\u9700\u8981\u4e86\u89e3\u8fd9\u4e9b\u7597\u6cd5\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u4f46\u6211\u4eec\u53ef\u4ee5\u5728\u672a\u67655\u5e74\u7684\u5f00\u53d1\u4e2d\u53d6\u5f97\u91cd\u5927\u8fdb\u5c55\u3002<\/strong><\/span><\/p>\n


<\/p>\n

\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u5373\u53ef\u8bbf\u95ee\u539f\u59cb\u82f1\u6587\u8bbf\u8c08\u5185\u5bb9\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u836f\u660e\u5eb7\u5fb7\u5e15\u91d1\u68ee\u75c5\u7cfb\u5217\u8bbf\u8c08\uff1a<\/span><\/strong><\/p>\n

\u5982\u4f55\u9488\u5bf9\u5e15\u91d1\u68ee\u75c5\u6839\u672c\u539f\u56e0\uff0c\u5f00\u53d1\u65b0\u7597\u6cd5\uff1f<\/span><\/a>
<\/p>\n

\u7784\u51c6\u795e\u7ecf\u5143\u518d\u751f\uff0c\u4f1a\u662f\u5e15\u91d1\u68ee\u75c5\u65b0\u836f\u5f00\u53d1\u7684\u7a81\u7834\u53e3\u5417\uff1f<\/a><\/span><\/p>\n


<\/span><\/p>\n

\u672c\u6587\u6765\u81ea\u836f\u660e\u5eb7\u5fb7\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n


<\/span><\/p>\n

\"\u5e15\u91d1\u68ee\u75c5\u7597\u6cd55\u5e74\u5185\u5c06\u6709\u91cd\u5927\u7814\u7a76\u7a81\u7834\uff1f<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u836f\u660e\u5eb7\u5fb7 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u7f16\u8005\u6309\uff1aMichael J. Fox\u5e15\u91d1\u68ee\u7814\u7a76\u57fa\u91d1\u4f1a\uff08MJFF\uff09\u6295\u5165\u8fd190%\u7684\u5f00\u652f\uff0c\u7528\u4e8e\u5f00\u53d1 […]<\/p>\n","protected":false},"author":1,"featured_media":29360,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29359"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=29359"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29359\/revisions"}],"predecessor-version":[{"id":29367,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29359\/revisions\/29367"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/29360"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=29359"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=29359"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=29359"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}