{"id":29417,"date":"2018-08-03T01:00:00","date_gmt":"2018-08-09T04:01:23","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e9%80%9f%e9%80%92-denali%e5%85%ac%e5%b8%83%e6%9c%80%e6%96%b0%e8%bf%9b%e5%b1%95%ef%bc%8c%e6%9c%89%e6%9c%9b%e9%80%a0%e7%a6%8f%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%e6%82%a3%e8%80%85\/"},"modified":"2018-08-09T12:01:29","modified_gmt":"2018-08-09T04:01:29","slug":"%e9%80%9f%e9%80%92-denali%e5%85%ac%e5%b8%83%e6%9c%80%e6%96%b0%e8%bf%9b%e5%b1%95%ef%bc%8c%e6%9c%89%e6%9c%9b%e9%80%a0%e7%a6%8f%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%85%e6%82%a3%e8%80%85","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/29417\/","title":{"rendered":"\u901f\u9012 | Denali\u516c\u5e03\u6700\u65b0\u8fdb\u5c55\uff0c\u6709\u671b\u9020\u798f\u5e15\u91d1\u68ee\u75c5\u60a3\u8005"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<h1 style=\"margin-bottom: 0.8em;font-weight: inherit;font-size: 1.7em;white-space: normal;box-sizing: border-box;word-wrap: break-word;border-width: 0px;border-style: initial;border-color: initial;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;line-height: inherit;\"><strong><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u258e\u836f\u660e<\/span><\/strong><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/h1>\n<h1 style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u65e5\u524d\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4ea7\u54c1\u7ec4\u5408\u7684\u751f\u7269\u533b\u836f\u516c\u53f8Denali Therapeutics\u5ba3\u5e03\uff0c\u5176LRRK2\u5c0f\u5206\u5b50\u6291\u5236\u5242\u65b0\u836fDNL201\u53d6\u5f971\u671f\u4e34\u5e8a\u7814\u7a76\u79ef\u6781\u6210\u679c\u3002<\/span><\/h1>\n<p style=\"white-space: normal;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533787284.jpeg\" alt=\"\u901f\u9012 | Denali\u516c\u5e03\u6700\u65b0\u8fdb\u5c55\uff0c\u6709\u671b\u9020\u798f\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\" title=\"\u901f\u9012 | Denali\u516c\u5e03\u6700\u65b0\u8fdb\u5c55\uff0c\u6709\u671b\u9020\u798f\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><br  \/><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5e15\u91d1\u68ee\u75c5\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u5728\u5168\u4e16\u754c\u8303\u56f4\u5185\u5f71\u54cd\u4e86\u7ea61000\u4e07\u4eba\u3002\u6211\u4eec\u5bf9\u4e8e\u5b83\u7684\u75c5\u56e0\u8fd8\u4e0d\u662f\u975e\u5e38\u4e86\u89e3\uff0c\u4f46\u4e00\u822c\u7684\u7406\u8bba\u8ba4\u4e3a\u5b83\u53d7\u5230\u4e86\u9057\u4f20\u4e0e\u73af\u5883\u56e0\u7d20\u7684\u5171\u540c\u5f71\u54cd\u30022004\u5e74\uff0c\u4e00\u7fa4\u79d1\u5b66\u5bb6\u4eec\u5728\u5e15\u91d1\u68ee\u75c5\u7684\u9057\u4f20\u5b66\u6839\u6e90\u4e0a\u505a\u51fa\u4e86\u91cd\u5927\u7a81\u7834\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u4e00\u6761\u53eb\u505a<em>LRRK2<\/em>\u7684\u57fa\u56e0\u4e00\u65e6\u53d1\u751f\u7a81\u53d8\uff0c\u5c31\u4f1a\u63d0\u9ad8\u5e15\u91d1\u68ee\u75c5\u7684\u53d1\u75c5\u98ce\u9669\u3002\u5b83\u4e5f\u662f\u6eb6\u9176\u4f53\u529f\u80fd\u969c\u788d\u7684\u4e3b\u8981\u9a71\u52a8\u56e0\u7d20\uff0c\u4f1a\u5bfc\u81f4\u8def\u6613\u4f53\u86cb\u767d\u805a\u96c6\u4f53\uff08Lewy body protein aggregates\uff09\u7684\u5f62\u6210\u548c\u795e\u7ecf\u53d8\u6027\u3002<strong>\u901a\u8fc7\u6291\u5236LRRK2\uff0c\u6709\u671b\u6062\u590d\u53d7\u635f\u7684\u6eb6\u9176\u4f53\u529f\u80fd\uff0c\u4ece\u800c\u6539\u53d8\u5177\u6709<em>LRRK2<\/em>\u7a81\u53d8\u53ca\u6563\u53d1\u6027\uff08sporadic\uff09\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55<\/strong>\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><span style=\"color: rgb(255, 255, 255);font-size: 15px;\">\u672c\u6587\u6765\u6e90\uff1a\u836f\u660e\u5eb7\u5fb7<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728\u5065\u5eb7\u53d7\u8bd5\u8005\u4e2d\u8fdb\u884c\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u53e3\u670d\u5242\u91cf\u7814\u7a76\u4e2d\uff0c<strong>DNL201\u5b9e\u73b0\u4e86\u5176\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u836f\u6548\u5b66\u76ee\u6807<\/strong>\u3002DNL201\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u5728\u8fbe\u5230\u9ad8\u6c34\u5e73\u8111\u810a\u6db2\uff08CSF\uff09\u66b4\u9732\u7684\u5242\u91cf\u4e0b\u6ca1\u6709\u4ea7\u751f\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u7528\u4e24\u79cd\u8840\u6db2LRRK2\u6d3b\u6027\u751f\u7269\u6807\u5fd7\u7269\u6d4b\u91cf\u65f6\u6709\u7a33\u5065\u7684\u9776\u6807\u53c2\u4e0e\uff0c\u4e14\u5bf9\u6eb6\u9176\u4f53\u529f\u80fd\u7684\u751f\u7269\u6807\u5fd7\u7269\u6709\u5f71\u54cd\u3002<br  \/><\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728DNL201\u7684\u7814\u7a76\u4e2d\uff0c\u8d85\u8fc7100\u540d\u5065\u5eb7\u53d7\u8bd5\u8005\u63a5\u53d7\u4e86\u5355\u6b21\u6216\u591a\u6b21\u9012\u589e\u5242\u91cf\u6216\u5b89\u6170\u5242\u6cbb\u7597\u3002\u57fa\u4e8e\u8be5\u7814\u7a76\u7684\u4e34\u5e8a\u6570\u636e\uff0c<strong>Denali\u6253\u7b97\u5728\u4eca\u5e74\u5e74\u5e95\u4e4b\u524d\u5c06DNL201\u63a8\u8fdb\u52301b\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u4e0d\u7ba1\u60a3\u8005\u662f\u5426\u5177\u6709<em>LRRK2<\/em>\u7a81\u53d8<\/strong>\u3002\u8be5\u7814\u7a76\u7684\u8be6\u7ec6\u4e34\u5e8a\u6570\u636e\u4f1a\u5728\u672a\u6765\u4e3e\u884c\u7684\u533b\u5b66\u4f1a\u8bae\u4e0a\u516c\u5e03\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\">\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;line-height: 1.75em;\"><strong><span style=\"font-size: 14px;color: rgb(0, 112, 192);\">\u25b2Denali\u9996\u5e2d\u533b\u5b66\u5b98Carole Ho\u535a\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1aDenali\u5b98\u65b9\u7f51\u7ad9\uff09<\/span><\/strong><br  \/><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u201c\u6211\u4eec\u4ece\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u51fa\u7ed3\u8bba\uff0cDNL201\u80fd\u591f\u5728\u5b89\u5168\u4e14\u8010\u53d7\u826f\u597d\u7684\u5242\u91cf\u4e0b\u8fbe\u5230\u6291\u5236LRRK2\u7684\u76ee\u6807\u6c34\u5e73\u3002\u6211\u4eec\u5f88\u9ad8\u5174\u8be5\u8bd5\u9a8c\u5728\u6240\u6709\u8fd9\u4e9b\u5173\u952e\u6d4b\u91cf\u4e2d\u53d6\u5f97\u4e86\u6210\u529f\u3002\u8bd5\u9a8c\u6570\u636e\u4f7f\u6211\u4eec\u6709\u4fe1\u5fc3\u5728\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u4e2d\u8fdb\u884c\u8fdb\u4e00\u6b65\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u4e3a\u672a\u6765\u7684\u4e34\u5e8a\u8bd5\u9a8c\u9009\u62e9\u6700\u4f73\u5242\u91cf\u63d0\u4f9b\u575a\u5b9e\u57fa\u7840\u3002\u201dDenali\u9996\u5e2d\u533b\u5b66\u5b98Carole Ho\u535a\u58eb\u8bf4\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">\u76f8\u5173\u9605\u8bfb\uff1a<\/span><\/strong><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzI5MDQzNjY2OA==&amp;mid=2247489012&amp;idx=1&amp;sn=b5f392d7accb4909db24c11ba8018b20&amp;chksm=ec1eb6a7db693fb181ed25651ee707d2d8f05872dfab17b7a5116ff62d5658df5925b44392c0&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;font-size: 15px;color: rgb(0, 112, 192);\"><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">Science\u5b50\u520a\uff1a\u79d1\u5b66\u5bb6\u4eec\u610f\u5916\u786e\u8ba4\u4e86\u5e15\u91d1\u68ee\u75c5\u7684\u57fa\u56e0\u5173\u952e<\/span><\/a><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u201c\u6211\u4eec\u5728\u6d4b\u8bd5\u4eba\u7c7bLRRK2\u6291\u5236\u5242\u65b9\u9762\u5904\u4e8e\u9886\u5148\u5730\u4f4d\uff0c\u76ee\u6807\u662f\u4e3a\u60a3\u6709\u5e15\u91d1\u68ee\u75c5\u7684\u60a3\u8005\u63d0\u4f9b\u4e00\u79cd\u6539\u5584\u75be\u75c5\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u201dDenali\u9996\u5e2d\u6267\u884c\u5b98Ryan Watts\u535a\u58eb\u8bf4\uff1a\u201c<strong>\u6211\u4eec\u4e5f\u611f\u5230\u500d\u53d7\u9f13\u821e\uff0c\u770b\u5230\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u652f\u6301LRRK2\u6291\u5236\u5242\u5728\u66f4\u5e7f\u6cdb\u7684\u6563\u53d1\u6027\u5e15\u91d1\u68ee\u75c5\u4eba\u7fa4\u4e2d\u8d77\u4f5c\u7528\uff0c\u800c\u4e0d\u4ec5\u4ec5\u662f\u5728\u4e0e<em>LRRK2<\/em>\u9057\u4f20\u7a81\u53d8\u76f8\u5173\u7684\u5e15\u91d1\u68ee\u75c5\u4e2d<\/strong>\u3002\u201d<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u6211\u4eec\u671f\u5f85\u8fd9\u4e00\u65b0\u7684\u7ed3\u679c\u80fd\u5c3d\u5feb\u4e3a\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u5e26\u6765\u6709\u6548\u7684\u65b0\u7597\u6cd5\u3002<\/span><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1]&nbsp;<\/span><span style=\"color: rgb(178, 178, 178);font-size: 10px;\">Denali Therapeutics Announces Positive Clinical Results From LRRK2 Inhibitor Program for Parkinson\u2019s Disease<\/span><\/p>\n<h2 class=\"rich_media_title\" style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2] Science\u5b50\u520a\uff1a\u79d1\u5b66\u5bb6\u4eec\u610f\u5916\u786e\u8ba4\u4e86\u5e15\u91d1\u68ee\u75c5\u7684\u57fa\u56e0\u5173\u952e<\/span><\/h2>\n<p style=\"white-space: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);line-height: normal;\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;word-wrap: break-word !important;\">\u672c\u6587\u6765\u81ea\u836f\u660e\u5eb7\u5fb7\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><br  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"__bg_gif\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533787284.gif\" alt=\"\u901f\u9012 | Denali\u516c\u5e03\u6700\u65b0\u8fdb\u5c55\uff0c\u6709\u671b\u9020\u798f\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\" title=\"\u901f\u9012 | Denali\u516c\u5e03\u6700\u65b0\u8fdb\u5c55\uff0c\u6709\u671b\u9020\u798f\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\"  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u660e\u5eb7\u5fb7                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u65e5\u524d\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4ea7\u54c1\u7ec4\u5408\u7684\u751f\u7269\u533b\u836f\u516c\u53f8Denali Therapeutics\u5ba3 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":29418,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29417"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=29417"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29417\/revisions"}],"predecessor-version":[{"id":29425,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29417\/revisions\/29425"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/29418"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=29417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=29417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=29417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}