{"id":29446,"date":"2018-08-03T01:00:00","date_gmt":"2018-08-09T04:01:39","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e7%9b%98%e7%82%b9-%e8%82%9d%e8%84%8f%e7%96%be%e7%97%85%e9%a2%86%e5%9f%9f%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e6%b1%87%e6%80%bb%ef%bc%88%e7%ac%ac41%e6%9c%9f%ef%bc%89\/"},"modified":"2018-08-09T12:01:41","modified_gmt":"2018-08-09T04:01:41","slug":"%e7%9b%98%e7%82%b9-%e8%82%9d%e8%84%8f%e7%96%be%e7%97%85%e9%a2%86%e5%9f%9f%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%e6%b1%87%e6%80%bb%ef%bc%88%e7%ac%ac41%e6%9c%9f%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/29446\/","title":{"rendered":"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c41\u671f\uff09"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong style=\"max-width: 100%;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u258e\u836f\u660e<\/span><\/strong><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">1\u3001\u81b3\u98df\u8865\u5145\u5242\u6709\u6f5c\u529b\u6cbb\u7597NAFLD<\/span><\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">\u65b0\u7814\u7a76\u663e\u793a\uff0c\u59dc\u9ec4\u63d0\u53d6\u7269\uff08turmeric extract\uff09BCM-95\u5c55\u793a\u4e86\u9884\u9632\u548c\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u75c5\uff08NAFLD\uff09\u7684\u6f5c\u529b\u3002<\/span><\/strong><span style=\"font-size: 15px;\">BCM-9\u662f\u79cd\u81b3\u98df\u8865\u5145\u5242\uff0c\u5b83\u5f3a\u5316\u4e86\u59dc\u9ec4\u7d20\uff08curcumin\uff09\u7684\u9012\u9001\u5f62\u5f0f\uff0c\u59dc\u9ec4\u7d20\u662f\u4e00\u79cd\u5929\u7136\u5b58\u5728\u7684\u690d\u7269\u591a\u915a\u3002BCM-95\u7684\u6210\u5206\u5305\u62ec\u7eaf\u59dc\u9ec4\u7d20\u548c\u59dc\u9ec4\u7cbe\u6cb9\uff0c\u80fd\u786e\u4fdd\u6e38\u79bb\u59dc\u9ec4\u7d20\u7684\u9ad8\u5ea6\u751f\u7269\u5229\u7528\u5ea6\u3002\u8fd9\u9879\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u5728\u300aPhysiological Reports\u300b\u4e0a\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533787300.jpeg\" alt=\"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c41\u671f\uff09\" title=\"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c41\u671f\uff09\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;text-align: center;\"><span style=\"font-size: 15px;\"><\/span><span style=\"color: rgb(178, 178, 178);font-size: 14px;\">\u56fe\u7247\u6765\u6e90\uff1a123RF<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u75c5\uff08NAFLD\uff09\u6b63\u5728\u8bb8\u591a\u56fd\u5bb6\u6210\u4e3a\u6700\u5e38\u89c1\u7684\u6162\u6027\u809d\u75c5\uff0c<strong>\u5728\u7f8e\u56fd\u5927\u7ea6\u67097500\u4e07\u52301\u4ebf\u7684NAFLD\u60a3\u8005\uff0c\u5728\u4e2d\u56fd\u4ea6\u662f\u6162\u6027\u809d\u75c5\u7684\u4e3b\u8981\u8d1f\u62c5\u4e4b\u4e00\uff0c\u5176\u6cbb\u7597\u65b9\u6cd5\u975e\u5e38\u6709\u9650\u3002<\/strong>NAFLD\u5305\u62ec\u4e00\u7cfb\u5217\u6162\u6027\u809d\u810f\u75be\u75c5\uff0c\u5176\u4e2d\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u662f\u6700\u5177\u4fb5\u88ad\u6027\u7684\u7c7b\u578b\u3002NAFLD\u548cNASH\u7684\u75c5\u56e0\u4ecd\u7136\u672a\u5b8c\u5168\u9610\u660e\uff0c\u76ee\u524d\u7684\u6807\u51c6\u62a4\u7406\u662f\u51cf\u80a5\u548c\u5065\u5eb7\u996e\u98df\uff0c\u8fd8\u6ca1\u6709FDA\u6279\u51c6\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u6240\u4ee5\u8fd8\u5b58\u5728\u5f88\u5927\u7684\u533b\u7597\u9700\u6c42\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(255, 255, 255);\">\u672c\u6587\u6765\u6e90\uff1a\u836f\u660e\u5eb7\u5fb7<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u8005\u5229\u7528\u5c0f\u9f20\u6a21\u578b\uff0c\u8bbe\u7acb\u4e864\u81c2\u5b9e\u9a8c\u6765\u68c0\u9a8c\u59dc\u9ec4\u7d20\u5bf9NAFLD\u7684\u4f5c\u7528\u3002<\/span><strong style=\"font-size: 15px;\">\u7ed3\u679c\u8868\u660e\uff0c\u8865\u5145\u81b3\u98df\u59dc\u9ec4\u7d20\u51cf\u5c11\u4e86\u708e\u75c7\u3001\u6c27\u5316\u5e94\u6fc0\u548c\u809d\u8102\u80aa\u53d8\u6027\uff0c\u4ece\u800c\u51cf\u7f13\u4e86NAFLD\u7684\u8fdb\u5c55\u3002<\/strong><span style=\"font-size: 15px;\">\u7814\u7a76\u8005\u8ba4\u4e3a\uff0c\u59dc\u9ec4\u7d20\u51cf\u5c11\u809d\u8102\u80aa\u53d8\u6027\u7684\u4f5c\u7528\u4e5f\u51cf\u7f13\u4e86\u66f4\u4e25\u91cd\u7684NASH\u7684\u8fdb\u5c55\uff0c\u5173\u952e\u8102\u80aa\u751f\u6210\u9176\uff08pACC \/ ACC\uff09\u548c\u8102\u8d28\u8f6c\u8fd0\u86cb\u767dApoB100\u7684\u589e\u52a0\u8bc1\u660e\u4e86\u8fd9\u4e00\u70b9\u3002\u5728\u6cbb\u7597\u548c\u9884\u9632\u6a21\u578b\u4e2d\uff0cBCM-95\u90fd\u964d\u4f4e\u4e86\u809d\u7ea4\u7ef4\u5316\u7684\u5206\u5b50\u6807\u5fd7\u7269\u6c34\u5e73\uff0c\u5e76\u663e\u8457\u964d\u4f4e\u4e86\u809d\u7ec6\u80de\u708e\u75c7\u4ee5\u53ca\u809d\u635f\u4f24\u7684\u8840\u6e05\u6807\u5fd7\u7269\uff08AST\u548cALP\uff09\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u7814\u7a76\u8005\u8fd8\u89c2\u5bdf\u5230\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08FGF\uff09\u6c34\u5e73\u964d\u4f4e\uff0c\u5b83\u4e0e\u80a5\u80d6\u548c\u8d85\u91cd\u4eba\u7fa4\u7684\u809d\u810f\u5bf9\u8840\u7cd6\u63a7\u5236\u7684\u6297\u6027\u76f8\u5173\u3002<\/span><br  \/><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">2\u3001HBV\u65b0\u836f\u83b7FDA\u5feb\u901f\u901a\u9053\u8d44\u683c<\/span><\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">Assembly Biosciences\u8fd1\u65e5\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u5df2\u6388\u4e88ABI-H0731\u5feb\u901f\u901a\u9053\u8d44\u683c\uff0c\u7528\u4e8e\u6cbb\u7597\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u60a3\u8005\u3002<\/span><\/strong><span style=\"font-size: 15px;\">ABI-H0731\u662fAssembly\u516c\u53f8\u7684\u53e3\u670dHBV\u6838\u5fc3\u86cb\u767d\u6291\u5236\u5242\uff0c\u76ee\u524d\u6b63\u5728\u4e24\u98792a\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fdb\u884c\u8bc4\u4f30\u3002\u5feb\u901f\u901a\u9053\u8d44\u683c\u901a\u5e38\u6388\u4e88\u6cbb\u7597\u4e25\u91cd\u75be\u75c5\u7684\u5728\u7814\u836f\u7269\uff0c\u5e76\u4e14\u6709\u4e34\u5e8a\u524d\u6570\u636e\u548c\/\u6216\u4e34\u5e8a\u8d44\u6599\u8bc1\u660e\u8be5\u836f\u7269\u5177\u6709\u89e3\u51b3\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u7684\u6f5c\u529b\u3002\u83b7\u5f97\u5feb\u901f\u901a\u9053\u8d44\u683c\u7684\u836f\u7269\u8ba9\u5176\u5f00\u53d1\u8005\u80fd\u4e0eFDA\u8fdb\u884c\u66f4\u9891\u7e41\u7684\u4ea4\u6d41\uff0c\u4ee5\u8ba8\u8bba\u836f\u7269\u7684\u53d1\u5c55\u8ba1\u5212\u548c\u5ba1\u67e5\u8fc7\u7a0b\uff0c\u8fd9\u5f80\u5f80\u4f7f\u5f97\u836f\u7269\u80fd\u591f\u5c3d\u65e9\u83b7\u5f97FDA\u6279\u51c6\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress6-1533787300.jpeg\" alt=\"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c41\u671f\uff09\" title=\"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c41\u671f\uff09\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><br  \/><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">\u5168\u4e16\u754c\u6709\u8d85\u8fc720\u4ebf\u4eba\u53d7HBV\u611f\u67d3\uff0c\u636e\u4f30\u8ba1\u6bcf\u5e74\u8fd8\u4f1a\u65b0\u589e5000\u4e07\u611f\u67d3\u8005\u3002\u5728\u73b0\u5728\u8eab\u60a3\u6162\u6027\u4e59\u578b\u809d\u708e\uff08CHB\uff09\u76842.4\u4ebf\u4eba\u4e2d\uff0c\u6709\u5927\u90e8\u5206\u60a3\u8005\u6765\u81ea\u4e9a\u6d32\u548c\u975e\u6d32\u3002<\/span><\/strong><span style=\"font-size: 15px;\">CHB\u53ef\u80fd\u4f1a\u53d1\u5c55\u6210\u4e3a\u809d\u786c\u5316\u548c\u809d\u8870\u7aed\uff0c\u5b83\u662f\u5bfc\u81f4\u809d\u7ec6\u80de\u764c\u7684\u4e3b\u8981\u539f\u56e0\u3002\u76ee\u524d\u53ef\u7528\u7684\u6297\u75c5\u6bd2\u6cbb\u7597\u53ef\u4ee5\u63a7\u5236\u75c5\u60c5\uff0c\u4f46\u4e0d\u80fd\u6cbb\u6108\u75be\u75c5\u3002\u5373\u4f7f\u5728\u957f\u671f\u6cbb\u7597\u4e0b\uff0c\u60a3\u8005\u4ecd\u7136\u5f88\u6709\u53ef\u80fd\u53d1\u5c55\u4e3a\u809d\u786c\u5316\u548c\u809d\u764c\uff0c\u56e0\u6b64\u8fd8\u6709\u5de8\u5927\u7684\u533b\u7597\u9700\u6c42\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">ABI-H0731\u662f\u79cd\u9ad8\u9009\u62e9\u6027\u3001\u5f3a\u6548\u3001\u591a\u6838\u5fc3\u86cb\u767d\u53d8\u6784\u8c03\u8282\u5242\uff08CpAMs\uff09\uff0c\u5b83\u5bf9HBV\u590d\u5236\u5468\u671f\u4e2d\u6838\u5fc3\u86cb\u767d\u53d1\u6325\u4f5c\u7528\u7684\u591a\u4e2a\u5173\u952e\u70b9\u6709\u5f71\u54cd\uff0c<\/span><\/strong><span style=\"font-size: 15px;\">\u80fd\u6291\u5236\u5bf9HBV\u751f\u5b58\u6709\u91cd\u8981\u4f5c\u7528\u7684\u86cb\u767d\u7684\u6d3b\u6027\uff0c\u4ee5\u53ca\u5e72\u6270HBV\u590d\u5236\u7684\u591a\u4e2a\u73af\u8282\uff0c\u4ece\u800c\u53d1\u6325\u6297\u75c5\u6bd2\u4f5c\u7528\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">Assembly\u6700\u8fd1\u5f00\u59cb\u4e86\u4e24\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684ABI-H0731 2a\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u76ee\u524d\u6b63\u5728\u591a\u4e2a\u5730\u70b9\u62db\u52df\u53d7\u8bd5\u8005\u3002\u5176\u4e2dABI-H0731-201\u201c\u75c5\u6bd2\u6297\u539f\u8bd5\u9a8c\u201d\u6b63\u5728\u62db\u52dfHBeAg\u9633\u6027\u7684HBV\u60a3\u8005\uff0c\u5176\u75c5\u6bd2\u8f7d\u91cf\u5df2\u7ecf\u88ab\u6807\u51c6\u62a4\u7406\u7684\u6838\u82f7\u7597\u6cd5\u6240\u6291\u5236\u3002\u60a3\u8005\u5c06\u88ab\u968f\u673a\u5206\u914d\uff0c\u6bcf\u65e5\u63a5\u53d7ABI-H0731\u6216\u5b89\u6170\u5242\u4ee5\u53ca\u6838\u82f7\u7c7b\u4f3c\u7269\u6cbb\u75976\u4e2a\u6708\u3002\u8be5\u8bd5\u9a8c\u5c06\u4e0e\u5355\u4e00\u7684\u6838\u82f7\u7597\u6cd5\u6bd4\u8f83HBV S\u6297\u539f\u548cHBV E\u6297\u539f\u7684\u4e0b\u964d\u7a0b\u5ea6\uff0c\u5e76\u8bc4\u4f30\u7597\u6cd5\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u5728ABI-H0731-202\u201c\u75c5\u6bd2\u8f7d\u91cf\u8bd5\u9a8c\u201d\u4e2d\uff0c\u6b63\u5728\u62db\u52df\u7684HBeAg\u9633\u6027HBV\u60a3\u8005\u5c1a\u672a\u63a5\u53d7\u8fc7\u6838\u82f7\u7597\u6cd5\uff0c\u4ed6\u4eec\u5c06\u88ab\u968f\u673a\u5206\u914d\uff0c\u6bcf\u65e5\u63a5\u53d7ABI-H0731\u6216\u5b89\u6170\u5242\u4e0e\u6069\u66ff\u5361\u97e6\uff08entecavir\uff09\u7684\u8054\u5408\u6cbb\u75976\u4e2a\u6708\u3002\u8be5\u8bd5\u9a8c\u5c06\u8bc4\u4f30\u4e0e\u5355\u72ec\u7684\u6069\u66ff\u5361\u97e6\u76f8\u6bd4\uff0c\u8054\u5408\u7528\u836f\u7684\u6297\u75c5\u6bd2\u6548\u529b\uff08\u5bf9\u75c5\u6bd2DNA\u7684\u6291\u5236\uff09\u4ee5\u53ca\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">3\u30011\u671f\u4e34\u5e8a\u7ed3\u679c\u79ef\u6781\uff0cPoxel\u8ba1\u5212\u542f\u52a82\u671f\u8bd5\u9a8c<\/span><\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">Poxel\u516c\u53f8\u8fd1\u65e5\u5ba3\u5e03\u4e86\u9488\u5bf9PXL770\u76841b\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u79ef\u6781\u7ed3\u679c\uff0c\u5176\u4e2d\u5305\u62ec\u4e86\u591a\u91cd\u5242\u91cf\u9012\u589e\uff08MAD\uff09\u548c\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7814\u7a76\u3002<strong>PXL770\u662f\u79cdbest-in-class\u7684\u817a\u82f7\u5355\u78f7\u9178\u6fc0\u6d3b\u86cb\u767d\u6fc0\u9176\uff08AMPK\uff09\u7684\u76f4\u63a5\u6fc0\u6d3b\u5242\u3002<\/strong>AMPK\u53c2\u4e0e\u8102\u8d28\u4ee3\u8c22\u3001\u8461\u8404\u7cd6\u5e73\u8861\u548c\u708e\u75c7\u7b49\u8bf8\u591a\u65b9\u9762\uff0c\u56e0\u5176\u5728\u591a\u79cd\u4ee3\u8c22\u9014\u5f84\u4e2d\u7684\u8c03\u8282\u4f5c\u7528\uff0c\u9776\u5411AMPK\u4e3a\u5305\u62ec\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u5728\u5185\u7684\u591a\u79cd\u6162\u6027\u4ee3\u8c22\u6027\u75be\u75c5\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u826f\u597d\u5207\u5165\u70b9\u3002\u7531\u4e8e\u7ed3\u679c\u79ef\u6781\uff0c\u516c\u53f8\u8ba1\u5212\u8fdb\u884c2a\u671f\u6982\u5ff5\u9a8c\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress1-1533787300.png\" alt=\"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c41\u671f\uff09\" title=\"\u76d8\u70b9 | \u809d\u810f\u75be\u75c5\u9886\u57df\u7814\u7a76\u8fdb\u5c55\u6c47\u603b\uff08\u7b2c41\u671f\uff09\"  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">NASH\u7684\u7279\u5f81\u662f\u8102\u80aa\u5728\u809d\u810f\u4e2d\u79ef\u805a\uff0c\u5e76\u8bf1\u53d1\u708e\u75c7\u548c\u7ea4\u7ef4\u5316\u3002<strong>\u5728\u4e2d\u56fd\u4e00\u4e9b\u5730\u533a\u7684NASH\u6d41\u884c\u7387\u53ef\u9ad8\u8fbe27%\u3002\u5728\u7f8e\u56fdNASH\u60a3\u8005\u4eba\u6570\u4e5f\u9ad8\u8fbe1600\u4e07\u3002<\/strong>\u5728\u6ca1\u6709\u5f97\u5230\u6709\u6548\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0cNASH\u53ef\u80fd\u4f1a\u8bf1\u53d1\u5305\u62ec\u809d\u764c\u5728\u5185\u7684\u4e25\u91cd\u809d\u810f\u95ee\u9898\u3002<\/span><br  \/><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">MAD\u8bd5\u9a8c\u5305\u62ec48\u540d\u53d7\u8bd5\u8005\uff0c\u8bc4\u4f30\u4e86PXL770\u7684\u5b89\u5168\u6027\uff0c\u8010\u53d7\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\uff0c\u60a3\u8005\u5206\u4e3a6\u4e2a\u5242\u91cf\u7ec4\uff0860mg\u81f3500mg\uff09\uff0c\u6bcf\u5929\u7ed9\u836f\u4e00\u6b21\u6216\u4e24\u6b21\u6301\u7eed10\u5929\u3002PXL770\u76f4\u81f3\u6700\u9ad8\u5242\u91cf\u90fd\u8010\u53d7\u826f\u597d\uff0c\u6ca1\u6709\u4e25\u91cd\u7684\u4e0d\u826f\u4e8b\u4ef6\u6216\u56e0\u5176\u5bfc\u81f4\u7684\u6212\u65ad\u3002\u9664\u4e86MAD\u8bd5\u9a8c\u4e4b\u5916\uff0c\u7814\u7a76\u8fd8\u6d4b\u8bd5\u4e86\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u68c0\u6d4b\u4e86\u7f57\u82cf\u4f10\u4ed6\u6c40\uff08rosuvastatin\uff09\u4e0ePXL770\u7684\u4f5c\u7528\u3002\u7f57\u82cf\u4f10\u4ed6\u6c40\u662f\u4e00\u79cd\u6709\u673a\u9634\u79bb\u5b50\u8f6c\u8fd0\u591a\u80bd\uff08OATP\uff09\u8f6c\u8fd0\u86cb\u767d\u7684\u63a2\u9488\u5e95\u7269\uff0c\u5b83\u662f\u4e00\u79cd\u4ed6\u6c40\u7c7b\u836f\u7269\uff0c\u53ef\u5f15\u8d77\u836f\u7269PK\u76f8\u4e92\u4f5c\u7528\u3002\u8be5\u7814\u7a76\u7ed912\u540d\u53d7\u8bd5\u8005\u6bcf\u5929\u4e00\u6b21\u65bd\u7528250mg\u5242\u91cf\u7684PXL770\u548c\u6807\u51c6\u5242\u91cf\u7684\u7f57\u82cf\u4f10\u4ed6\u6c40\u3002<strong>\u7ed3\u679c\u8868\u660e\uff0cPXL770\u548cOATP\u5e95\u7269\u4e4b\u95f4\u6ca1\u6709\u836f\u7269PK\u76f8\u4e92\u4f5c\u7528\u3002<\/strong><\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">4\u3001\u53d1\u73b0FXR\u4e0a\u6e38\u6fc0\u9176\uff0c\u6709\u671b\u6210\u4e3a\u80a0\u809d\u75be\u75c5\u65b0\u751f\u7269\u6807\u5fd7\u7269<\/span><\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8fd1\u65e5\uff0c\u6765\u81ea\u7f8e\u56fdUIUC\u7b49\u591a\u4e2a\u7814\u7a76\u673a\u6784\u7684\u7814\u7a76\u7ec4\u53d1\u73b0\uff0csrc\u78f7\u9178\u5316\u7c7b\u6cd5\u5c3c\u9187\u53d7\u4f53\uff08Farnesoid-X-Receptor\uff0cFXR\uff09\u5bf9\u80c6\u6c41\u9178\uff08BA\uff09\u7a33\u6001\u81f3\u5173\u91cd\u8981\uff0c<strong>\u7531src\u4ecb\u5bfc\u7684FXR\u78f7\u9178\u5316\u6709\u6f5c\u529b\u6210\u4e3aBA\u76f8\u5173\u80a0\u809d\u75be\u75c5\u7684\u6cbb\u7597\u9776\u6807\u548c\u751f\u7269\u6807\u5fd7\u7269\u3002<\/strong>\u8bba\u6587\u53d1\u8868\u5728\u300a\u81ea\u7136\u300b\u5b50\u520a\u300aNature Communications\u300b\u4e0a\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">FXR\u662f\u6838\u53d7\u4f53\u8d85\u5bb6\u65cf\u7684\u4e00\u5458\uff0c\u4e3b\u8981\u8868\u8fbe\u5728\u80a0\u9053\u7cfb\u7edf\u4e4b\u4e2d\uff0c\u53c2\u4e0e\u80c6\u6c41\u9178\u4ee3\u8c22\u4e0e\u80c6\u56fa\u9187\u4ee3\u8c22\u7b49\u91cd\u8981\u73af\u8282\uff0c<\/span><\/strong><span style=\"font-size: 15px;\">\u5b83\u901a\u8fc7\u8f6c\u5f55\u63a7\u5236\u8bb8\u591a\u80a0\u809d\u57fa\u56e0\uff0c\u5176\u4e2d\u5305\u62ec\u80a0\u9053<em>FGF19<\/em>\uff0c\u5b83\u7f16\u7801\u4e00\u79cd\u80fd\u5f3a\u70c8\u6291\u5236\u809d\u810fBA\u5408\u6210\u7684\u6fc0\u7d20\uff0c\u56e0\u6b64FXR\u5728\u7ef4\u6301BA\u7a33\u6001\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u4f46\u76ee\u524d\uff0c\u5bf9\u4e8eFGF19\u53d7\u4f53\u6fc0\u6d3b\u540e\u4fe1\u53f7\u662f\u5982\u4f55\u4f20\u9012\u81f3\u7ec6\u80de\u6838\u5185\uff0c\u4ee5\u53caFGF19\u662f\u5426\u8c03\u8282FXR\u529f\u80fd\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4ecd\u5c5e\u672a\u77e5\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">src\u662f\u79cd\u975e\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\uff0c\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u8005\u663e\u793a\u4e86src\u80fd\u54cd\u5e94\u9910\u540eFGF19\uff0c\u5bf9FXR\u7684\u916a\u6c28\u917867\uff08Y67\uff09\u8fdb\u884c\u78f7\u9178\u5316\uff0c\u8fd9\u5bf9FXR\u8f6c\u79fb\u5230\u6838\u4e2d\u4ee5\u53ca\u8c03\u8282BA\u8f6c\u5f55\u6c34\u5e73\u81f3\u5173\u91cd\u8981\u3002\u91c7\u7528\u809d\u7279\u5f02\u6027\u8868\u8fbe\u78f7\u9178\u7f3a\u9677\u578bY67F-FXR\uff0c\u4ee5\u53casrc\u4e0b\u8c03\u7684\u5c0f\u9f20\u5b9e\u9a8c\uff0c\u90fd\u4ee4BA\u7684\u7a33\u6001\u53cd\u5e94\u53d7\u635f\uff0c\u5e76\u4e14\u80fd\u5728\u836f\u7269\u8bf1\u5bfc\u7684\u809d\u80c6\u635f\u4f24\u4e2d\u52a0\u5267\u80c6\u6c41\u6de4\u79ef\u3002\u5e76\u4e14\uff0c\u809dFGF19-Src-FXR\u4fe1\u53f7\u901a\u8def\u5728\u539f\u53d1\u6027\u80c6\u6c41\u6027\u809d\u786c\u5316\uff08PBC\uff09\u60a3\u8005\u4e2d\u6709\u7f3a\u9677\u3002\u8fd9\u4e2a\u65b0\u53d1\u73b0\u8fde\u63a5\u4e86\u9910\u540eFGF19\u548cBA\u4e4b\u95f4\u7684\u8c03\u63a7\u5173\u7cfb\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;color: rgb(0, 112, 192);\">5\u3001\u65b0\u5408\u4f5c\u51fa\u7089\uff0cAlteogen\u548cLynkogen\u8054\u624b\u5bf9\u6297NASH<\/span><\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">Alteogen\u516c\u53f8\u548cLynkogen\u516c\u53f8\u8fd1\u65e5\u5ba3\u5e03\uff0c\u4ed6\u4eec\u5df2\u7ecf\u7b7e\u8ba2\u5408\u4f5c\u534f\u8bae\uff0c\u7528\u4e8e\u5f00\u53d1Alteogen\u7684\u65b0\u578bGLP-1\u6a21\u62df\u7269\u548cAlpha-1\u6297\u80f0\u86cb\u767d\u9176\uff08A1AT\uff09\u878d\u5408\u86cb\u767d\uff0c\u4ee5\u89e3\u51b3\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u548c\u4ee3\u8c22\u75be\u75c5\u3002<\/span><\/strong><span style=\"font-size: 15px;\">\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0cLynkogen\u5c06\u72ec\u5bb6\u62e5\u6709\u9664\u4e86\u97e9\u56fd\u548c\u65b0\u5174\u5e02\u573a\u4e4b\u5916\u7684\u5168\u7403\u6743\u5229\uff0c\u4ee5\u5f00\u53d1\u548c\u63a8\u5e7f\u6cbb\u7597\u6027GLP-1\u548cA1AT\u878d\u5408\u86cb\u767d\u3002Alteogen\u5c06\u6709\u8d44\u683c\u83b7\u5f97\u5f00\u53d1\uff0c\u76d1\u7ba1\u548c\u5546\u4e1a\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u5e76\u83b7\u5f97Lynkogen\u7684\u80a1\u6743\u3002<\/span><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;\">\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\"><\/span><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">NASH\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u809d\u75c5\uff0c\u5b83\u4e0e\u4f7f\u7528\u9152\u7cbe\u65e0\u5173\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u809d\u810f\u8102\u80aa\u5806\u79ef\u3001\u708e\u75c7\u3001\u809d\u7ec6\u80de\u635f\u4f24\uff08\u6c14\u7403\u6837\u53d8\uff09\u548c\u7ea4\u7ef4\u5316\u589e\u52a0\u3002<strong>NASH\u4f1a\u7ed9\u5f88\u591a\u60a3\u8005\u5e26\u6765\u6c38\u4e45\u6027\u635f\u4f24\uff0c\u5305\u62ec\u809d\u786c\u5316\u548c\u809d\u529f\u80fd\u53d7\u635f\u3002\u52302020\u5e74\uff0cNASH\u53ef\u80fd\u6210\u4e3a\u809d\u810f\u79fb\u690d\u7684\u4e3b\u8981\u539f\u56e0<\/strong>\u3002\u5c3d\u7ba1\u5b58\u5728\u5de8\u5927\u7684\u672a\u6ee1\u8db3\u9700\u6c42\uff0c\u4f46\u76ee\u524dNASH\u60a3\u8005\u5c1a\u65e0\u6279\u51c6\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/span><br  \/><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u56e0\u4e3aNASH\u5177\u6709\u591a\u79cd\u8bf1\u56e0\uff0c\u6240\u4ee5\u9700\u8981\u6709\u80fd\u591f\u89e3\u51b3\u591a\u79cd\u8bf1\u56e0\u7684\u6cbb\u7597\u65b9\u6cd5\u3002Alteogen\u57fa\u4e8e\u5176\u4e13\u6709\u7684NexPTM\u878d\u5408\u6280\u672f\u7684GLP-1\u548cA1AT\u878d\u5408\u86cb\u767d\u7597\u6cd5\u80fd\u540c\u65f6\u9488\u5bf9\u4ee3\u8c22\u548c\u708e\u75c7\u9014\u5f84\uff0c\u6709\u53ef\u80fd\u4e3a\u60a3\u8005\u63d0\u4f9b\u6cbb\u7597NASH\u548c\u5176\u4ed6\u590d\u6742\u4ee3\u8c22\u7d0a\u4e71\u7684\u72ec\u7279\u6cbb\u7597\u9009\u62e9\u3002<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1] Curcumin Extract Targets Fatty Liver Disease<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2] Assembly Biosciences Announces FDA Fast Track Designation Granted to ABI-H0731 for the Treatment of Hepatitis B Virus Infection<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[3] Poxel Announces Favorable Results for PXL770 Phase 1b Multiple Ascending Dose Trial and Drug-Drug Interaction Study<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[4] Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis<\/span><\/p>\n<p style=\"white-space: normal;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[5] Alteogen and Lynkogen Enter into an Exclusive Option Agreement to Develop Proprietary Fusion Proteins for the Treatment of NASH and Metabolic Diseases<\/span><\/p>\n<p 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