{"id":29493,"date":"2018-08-01T01:00:00","date_gmt":"2018-08-09T04:01:58","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e7%9b%98%e7%82%b9-%e4%b8%ad%e6%9e%a2%e7%a5%9e%e7%bb%8f%e7%b3%bb%e7%bb%9f%e7%96%be%e7%97%85%e9%a2%86%e5%9f%9f%e8%bf%91%e6%9c%9f%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%ef%bc%88%e7%ac%ac58%e6%9c%9f\/"},"modified":"2018-08-09T12:02:01","modified_gmt":"2018-08-09T04:02:01","slug":"%e7%9b%98%e7%82%b9-%e4%b8%ad%e6%9e%a2%e7%a5%9e%e7%bb%8f%e7%b3%bb%e7%bb%9f%e7%96%be%e7%97%85%e9%a2%86%e5%9f%9f%e8%bf%91%e6%9c%9f%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95%ef%bc%88%e7%ac%ac58%e6%9c%9f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/29493\/","title":{"rendered":"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c58\u671f\uff09"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong style=\"white-space: normal;max-width: 100%;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u258e\u836f\u660e<\/span><\/strong><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 112, 192);\"><strong><span style=\"font-size: 15px;\">1. \u91cd\u78c5\uff01\u963f\u5179\u6d77\u9ed8\u75c5\u65b0\u836f2\u671f\u79ef\u6781\u6570\u636e\u7ec8\u4e8e\u63ed\u6653<\/span><br  \/><\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 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center;\"><span style=\"font-size: 15px;\"><img class=\"\"       style=\"color: rgb(51, 51, 51);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533787319.jpg\" alt=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c58\u671f\uff09\" title=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c58\u671f\uff09\"  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u963f\u5179\u6d77\u9ed8\u75c5\u662f\u6700\u4e3a\u5e38\u89c1\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e4b\u4e00\uff0c\u53d1\u75c5\u7387\u968f\u5e74\u9f84\u4e0a\u5347\u800c\u8fc5\u901f\u589e\u52a0\uff0c\u81f3\u4eca\u60a3\u8005\u4eec\u4f9d\u65e7\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6848\u3002\u968f\u7740\u793e\u4f1a\u8001\u9f84\u5316\u7a0b\u5ea6\u7684\u52a0\u5267\uff0c\u8fd9\u4e00\u75be\u75c5\u5c06\u4f1a\u5e26\u6765\u8d8a\u6765\u8d8a\u4e25\u91cd\u7684\u8d1f\u62c5\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">BAN2401\u662f\u4e00\u6b3e\u4eba\u6e90\u5316\u7684\u6297\u4f53\uff0c\u80fd\u9009\u62e9\u6027\u6291\u5236\u03b2-\u6dc0\u7c89\u6837\u539f\u7ea4\u7ef4\u3002<\/span><\/strong><span style=\"font-size: 15px;\">\u6309\u8bbe\u8ba1\uff0c\u5b83\u6709\u671b\u901a\u8fc7\u51cf\u5c11\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u6765\u6539\u5584\u963f\u5179\u6d77\u9ed8\u75c5\u7684\u75c5\u60c5\u3002\u867d\u7136\u572812\u4e2a\u6708\u7684\u8282\u70b9\u4e0a\uff0c\u8fd9\u6b3e\u65b0\u836f\u672a\u80fd\u8fbe\u5230\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\uff0c\u4f46\u572818\u4e2a\u6708\u7684\u8282\u70b9\u4e0a\uff0c\u8be5\u836f\u7269\u663e\u793a\u80fd\u4e3a\u75be\u75c5\u8fdb\u5c55\u5e26\u6765\u663e\u8457\u7f13\u89e3\u3002\u800cPET\u5206\u6790\u7ed3\u679c\u4e5f\u8868\u660e\uff0c\u60a3\u8005\u5927\u8111\u4e2d\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u6c34\u5e73\u6709\u663e\u8457\u4e0b\u964d\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><span style=\"color: rgb(255, 255, 255);font-size: 15px;\">\u672c\u6587\u6765\u6e90\uff1a\u836f\u660e\u5eb7\u5fb7<\/span><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 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1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress1-1533787319.jpeg\" alt=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c58\u671f\uff09\" title=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c58\u671f\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u25b2<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8be5\u7814\u7a76\u7684\u90e8\u5206\u6570\u636e<\/strong>\uff08\u56fe\u7247\u6765\u6e90\uff1a\u536b\u6750\uff09<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u7ed3\u679c\u663e\u793a\uff0cBAN2401\u5728\u6dc0\u7c89\u6837\u86cb\u767d\u7684\u51cf\u5c11\u4e0a\u5c55\u73b0\u4e86\u5242\u91cf\u76f8\u5173\u6027\u3002\u5728\u6700\u9ad8\u5242\u91cf\u7ec4\uff08\u6bcf2\u546810mg\/kg\uff09\u4e2d\uff0c\u4f7f\u7528\u6807\u51c6PET\u65b9\u6cd5\u8bc4\u4f30\u4e0b\uff0c\u60a3\u8005\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u5e73\u5747\u57fa\u7ebf\u503c\u4e3a74.5\uff0c\u800c18\u4e2a\u6708\u7684\u5e73\u5747\u6570\u503c\u4e3a5.5\uff0c\u4e0b\u964d\u8fd170\u4e2a\u5355\u4f4d\uff0c\u5177\u6709\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u8457\u6027\uff08p&lt;0.0001\uff09\u3002\u6b64\u5916\u572818\u4e2a\u6708\u65f6\uff0c\u670981%\u7684\u60a3\u8005\u72b6\u6001\u4ece\u6dc0\u7c89\u6837\u86cb\u767d\u9633\u6027\u8f6c\u4e3a\u9634\u6027\uff08p&lt;0.0001\uff09\u3002\u5229\u7528\u5e38\u89c4\u7684\u7edf\u8ba1\u65b9\u6cd5\uff0c\u8fd9\u9879\u7814\u7a76\u62b5\u8fbe\u4e86\u9884\u8bbe\u7684\u6700\u7ec8\u7597\u6548\u7ec8\u70b9\uff1a\u572818\u4e2a\u6708\u65f6\uff0cBAN2401\u5ef6\u7f13\u4e86\u75be\u75c5\u7684\u8fdb\u5c55\u3002\u5229\u7528\u5e38\u89c4\u65b9\u6cd5\u7edf\u8ba1\uff0c\u6700\u9ad8\u5242\u91cf\u7ec4\u76f8\u8f83\u4e8e\u5b89\u6170\u5242\u7ec4\uff0c\u60a3\u8005\u7684\u4e34\u5e8a\u8870\u9000\u51cf\u5c11\u4e8630%\uff08p=0.034\uff09\uff0c\u800c\u4f9d\u7167ADAS-Cog\u7edf\u8ba1\uff0c\u6700\u9ad8\u5242\u91cf\u7ec4\u66f4\u662f\u5ef6\u7f13\u4e86\u4e34\u5e8a\u8870\u9000\u8fbe47%\uff08p=0.017\uff09\u3002\u8be5\u7ed3\u679c\u4e3a\u6dc0\u7c89\u6837\u86cb\u767d\u5047\u8bf4\u63d0\u4f9b\u4e86\u652f\u6301\u3002<\/span><\/p>\n<p><br 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15px;\">GLP-1\uff08\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\uff09\u53d7\u4f53\u6fc0\u52a8\u5242\u662f\u4e00\u7c7b\u5e38\u7528\u76842\u578b\u7cd6\u5c3f\u75c5\u836f\u7269\u3002\u5b83\u53ef\u80fd\u4f5c\u7528\u4e8e\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff0c\u6240\u4ee5\u79d1\u5b66\u5bb6\u4eec\u5728\u7814\u7a76GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u7528\u4e8e\u5176\u5b83\u795e\u7ecf\u9000\u5316\u75be\u75c5\u7684\u53ef\u80fd\u6027\u3002\u6700\u8fd1\uff0c\u97e9\u56fd\u751f\u7269\u6280\u672f\u516c\u53f8Peptron\u53d1\u73b0\u4e86\u827e\u585e\u90a3\u80bd\uff08\u963f\u5229\u65af\u5eb7\u7684Byetta\u548cBydureon\u7684\u4e3b\u8981\u6210\u5206\uff09\u7684\u4e00\u4e9b\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u3002\u7814\u7a76\u53d1\u8868\u5728\u300aScientific Reports\u300b\u6742\u5fd7\u4e0a\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 15px;\"><img class=\"\"       style=\"color: rgb(51, 51, 51);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress4-1533787320.jpg\" alt=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c58\u671f\uff09\" title=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c58\u671f\uff09\"  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u662f\u79cd\u4ec5\u6b21\u4e8e\u963f\u5179\u6d77\u9ed8\u75c5\u7684\u5e38\u89c1\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u5728\u5168\u740360\u5c81\u4ee5\u4e0a\u7684\u4eba\u7fa4\u4e2d\u53d1\u75c5\u7387\u7ea6\u4e3a1\uff05\u3002PD\u7684\u73b0\u6709\u7597\u6cd5\u6ca1\u6709\u4e00\u4e2a\u5bf9\u75be\u75c5\u8fdb\u5c55\u6709\u663e\u8457\u7597\u6548\u3002\u8fc7\u53bb\u7684\u7814\u7a76\u8868\u660e\uff0c\u80f0\u5c9b\u7d20\u4fe1\u53f7\u901a\u8def\u7684\u635f\u4f24\u53ef\u80fd\u4e0ePD\u53d1\u75c5\u76f8\u5173\uff0c\u6d41\u884c\u75c5\u5b66\u5206\u6790\u4e5f\u8868\u660e\u7cd6\u5c3f\u75c5\u4e0e\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e4b\u95f4\u5b58\u5728\u8054\u7cfb\u3002GLP-1\u53d7\u4f53\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\u666e\u904d\u5b58\u5728\uff0c\u5b83\u4eec\u53ef\u5728\u51e0\u79cd\u9014\u5f84\u4e2d\u8d77\u4f5c\u7528\uff0c\u800c\u8fd9\u4e9b\u9014\u5f84\u53ef\u4ee5\u589e\u5f3a\u7ec6\u80de\u5b58\u6d3b\u5e76\u4fc3\u8fdb\u795e\u7ecf\u4fdd\u62a4\u3002<strong>\u56e0\u6b64\uff0c\u9776\u5411GLP-1\u6709\u53ef\u80fd\u540c\u65f6\u6539\u5584\u8461\u8404\u7cd6\u4ee3\u8c22\u548c\u963b\u6b62PD\u8fdb\u5c55\u3002<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong><br  \/><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533787320.jpg\" alt=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c58\u671f\uff09\" title=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c58\u671f\uff09\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\">\u25b2\u63a5\u53d7PT302\u76843\u53ea\u5927\u9f20\u8bd5\u9a8c\u7ed3\u679c\uff08\u56fe\u7247\u6765\u6e90\uff1a\u300aScientific Reports\u300b\uff09<\/span><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u4e4b\u524d\u7684\u7814\u7a76\u663e\u793a\uff0c\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u7528Exendin-4\uff08\u827e\u585e\u90a3\u80bd\u6240\u6a21\u62df\u7684\u5929\u7136\u6fc0\u7d20\uff09\u9884\u5904\u7406\u53ef\u51cf\u5c11\u591a\u5df4\u80fa\u6027\u795e\u7ecf\u9000\u884c\uff0c\u4f46Exendin-4\u5728\u5e15\u91d1\u68ee\u75c5\u4e2d\u7684\u5e94\u7528\u53d7\u5230\u5176\u534a\u8870\u671f\u77ed\u548c\u8840\u8111\u5c4f\u969c\u7684\u9650\u5236\u3002\u8840\u8111\u5c4f\u969c\u53ef\u4ee5\u963b\u6b62\u8840\u6db2\u4e2d\u7684\u67d0\u4e9b\u5206\u5b50\u8fdb\u5165\u5927\u8111\uff0c\u56e0\u6b64\u96be\u4ee5\u5c06\u6cbb\u7597\u836f\u7269\u5242\u91cf\u9012\u9001\u81f3\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u3002\u4e3a\u4e86\u514b\u670d\u8fd9\u4e9b\u7f3a\u70b9\uff0cPeptron\u7814\u53d1\u4e86\u4e00\u79cd\u540d\u4e3aPT302\u7684\u7f13\u91ca\u578b\u827e\u585e\u90a3\u80bd\u3002\u5728PD\u7684\u5927\u9f20\u6a21\u578b\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u8005\u53d1\u73b0\u5355\u5242PT302\u53ef\u5728\u5927\u9f20\u8840\u6d46\u5185\u4fdd\u6301\u957f\u8fbe20\u5929\u7684\u9ad8\u6d53\u5ea6\uff0c\u540c\u65f6\u4e0e\u975e\u7f13\u91ca\u578b\u76f8\u6bd4\uff0cPT302\u5728\u8111\u810a\u6db2\u4e2d\u7684\u6d53\u5ea6\u66f4\u9ad8\uff08&lt;6.9 pg\/ml\u5bf9\u6bd418.3\u81f330 pg\/ml\uff09\u3002<strong>\u66f4\u6709\u610f\u4e49\u7684\u662f\uff0c\u5728\u4e00\u4fa76-\u7f9f\u57fa\u591a\u5df4\u80fa\u635f\u4f24\u7684\u5927\u9f20\u5927\u8111\u4e2d\uff0cPT302\u53ef\u4ee5\u5728\u8111\u635f\u4f24\u4fa7\u663e\u8457\u63d0\u9ad8\u8111TH-IR\uff08\u916a\u6c28\u9178\u7f9f\u5316\u9176\u514d\u75ab\u53cd\u5e94\u6027\uff09\uff0c\u5b83\u662f\u591a\u5df4\u80fa\u6027\u795e\u7ecf\u5143\u7684\u6d4b\u91cf\u6807\u5fd7\u3002<\/strong>\u76ee\u524d\u5e15\u91d1\u68ee\u75c5\u53ca\u5176\u4ed6\u8111\u75be\u75c5\u7684\u6cbb\u7597\u53ea\u80fd\u6539\u5584\u75c7\u72b6\u5982\u6539\u5584\u8fd0\u52a8\u548c\u8ba4\u77e5\u529f\u80fd\uff0c\u4f46\u65e0\u6cd5\u6539\u5584\u5176\u672c\u8d28\u6027\u7684\u795e\u7ecf\u9000\u884c\u8fc7\u7a0b\uff0c\u8fd9\u4e00\u62a5\u9053\u4e2d\u7684\u6570\u636e\u663e\u793a\u4e86PT302\u6539\u5584\u672c\u8d28\u6027\u795e\u7ecf\u9000\u884c\u8fc7\u7a0b\u7684\u6f5c\u529b\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 112, 192);\"><strong><span style=\"font-size: 15px;\">3. FDA\u8ba4\u53ef\uff0c\u5e15\u91d1\u68ee\u75c5\u57fa\u56e0\u7597\u6cd5\u6709\u671b\u63d0\u524d\u83b7\u5f97\u5ba1\u8bc4\uff1f<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u751f\u7269\u533b\u836f\u516c\u53f8Voyager Therapeutics\u8fd1\u65e5\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u5df2\u7ed9\u516c\u53f8\u4e66\u9762\u7b54\u590d\uff0c\u8ba4\u53ef\u4e86Voyager\u7684\u5e15\u91d1\u68ee\u75c5\u521b\u65b0\u7597\u6cd5VY-AADC\u76842\u671f\u548c3\u671f\u5173\u952e\u4e34\u5e8a\u8bd5\u9a8c\u8ba1\u5212\u3002<strong>\u5982\u679c2\u671f\u8bd5\u9a8c\u7ed3\u679c\u79ef\u6781\uff0cVY-AADC\u53ef\u76f4\u63a5\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\u3002\u8fd9\u4e5f\u610f\u5473\u7740\u8fd9\u6b3e\u521b\u65b0\u5e15\u91d1\u68ee\u75c5\u57fa\u56e0\u7597\u6cd5\u6709\u671b\u63d0\u524d\u83b7\u5f97\u5ba1\u8bc4\uff0c\u52a0\u901f\u6765\u5230\u60a3\u8005\u8eab\u8fb9\u3002<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 15px;\"><img class=\"\"       style=\"color: rgb(51, 51, 51);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533787320.jpeg\" alt=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c58\u671f\uff09\" title=\"\u76d8\u70b9 | \u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u9886\u57df\u8fd1\u671f\u7814\u7a76\u8fdb\u5c55\uff08\u7b2c58\u671f\uff09\"  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5e15\u91d1\u68ee\u75c5\uff08PD\uff09\u662f\u4e00\u79cd\u5f71\u54cd\u5e7f\u6cdb\u7684\u6162\u6027\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u5168\u7403\u7ea6\u6709 700-1000 \u4e07\u540d\u60a3\u8005\u3002\u8be5\u75be\u75c5\u7684\u8fd0\u52a8\u75c7\u72b6\u662f\u7531\u4e8e\u4ea7\u751f\u795e\u7ecf\u9012\u8d28\u591a\u5df4\u80fa\u7684\u4e2d\u8111\u795e\u7ecf\u5143\u7f3a\u5931\u5f15\u8d77\u7684\uff0c\u5de6\u65cb\u591a\u5df4\u662f\u8be5\u75be\u75c5\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6cd5\u3002\u4f46\u968f\u7740\u75be\u75c5\u8fdb\u5c55\uff0c\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\u4f1a\u9010\u6e10\u53d8\u5dee\uff0c\u7ecf\u5386\u8f83\u957f\u65f6\u95f4\u7684\u8fd0\u52a8\u7f13\u6162\u548c\u50f5\u786c\uff0c\u7528\u836f\u4e5f\u65e0\u6cd5\u8fbe\u5230\u6700\u4f73\u6548\u679c\uff0c\u8fd9\u4e00\u65f6\u671f\u53eb\u505a\u201c\u5173\u95ed\u671f\uff08OFF-time\uff09\u201d\u3002\u836f\u7269\u8d77\u6548\u7684\u65f6\u95f4\uff0c\u4e5f\u5c31\u662f\u201c\u5f00\u542f\u671f\uff08ON-time\uff09\u201d\u4e5f\u53d8\u77ed\u3002\u636e\u4f30\u8ba1\uff0c\u9ad8\u8fbe 15% \u7684\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\u5177\u6709\u96be\u6cbb\u6027\u8fd0\u52a8\u6ce2\u52a8\uff0c\u5de6\u65cb\u591a\u5df4\u4e5f\u65e0\u6cd5\u6709\u6548\u63a7\u5236\u3002\u56e0\u6b64\uff0c\u8fd9\u7c7b\u60a3\u8005\u6025\u9700\u6f5c\u5728\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u6539\u5584\u4ed6\u4eec\u7684\u75c5\u60c5\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(0, 112, 192);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u25b2<\/strong><\/em>VY-AADC\u662fVoyager Therapeutics\u7684\u9886\u5148\u7597\u6cd5\uff08\u56fe\u7247\u6765\u6e90\uff1aVoyager Therapeutics\u5b98\u65b9\u7f51\u7ad9\uff09<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 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style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 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style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1] Eisai and Biogen Present Detailed Results From Phase II Clinical Study of Elenbecestat in MCI and Mild to Moderate Alzheimer\u2019s Disease at Alzheimer\u2019s Association International Conference (AAIC) 2018<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2] Repurposing a GLP-1 diabetes drug to slow Parkinson\u2019s disease<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[3] Voyager Therapeutics Receives FDA Guidance on Development Path for VY-AADC for Parkinson\u2019s Disease and Provides Clinical Update<\/span><\/p>\n<p><br  \/><\/p>\n<p 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