{"id":29559,"date":"2018-07-31T01:00:00","date_gmt":"2018-08-09T04:02:27","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e9%80%9f%e9%80%92-%e6%98%be%e8%91%97%e5%87%8f%e5%b0%91%e4%b8%8a%e7%98%be%e9%a3%8e%e9%99%a9%ef%bc%8c%e6%96%b0%e5%9e%8b%e6%ad%a2%e7%96%bc%e8%8d%af%e9%80%92%e4%ba%a4%e4%b8%8a%e5%b8%82%e7%94%b3\/"},"modified":"2018-08-09T12:02:30","modified_gmt":"2018-08-09T04:02:30","slug":"%e9%80%9f%e9%80%92-%e6%98%be%e8%91%97%e5%87%8f%e5%b0%91%e4%b8%8a%e7%98%be%e9%a3%8e%e9%99%a9%ef%bc%8c%e6%96%b0%e5%9e%8b%e6%ad%a2%e7%96%bc%e8%8d%af%e9%80%92%e4%ba%a4%e4%b8%8a%e5%b8%82%e7%94%b3","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/29559\/","title":{"rendered":"\u901f\u9012 | \u663e\u8457\u51cf\u5c11\u4e0a\u763e\u98ce\u9669\uff0c\u65b0\u578b\u6b62\u75bc\u836f\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"line-height: 1.75em;\"><strong style=\"white-space: normal;max-width: 100%;color: rgb(51, 51, 51);\"><strong style=\"max-width: 100%;line-height: 32px;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: SimSun;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u258e\u836f\u660e<\/span><\/strong><strong style=\"max-width: 100%;line-height: 1.75em;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);font-family: \u6977\u4f53;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5eb7\u5fb7\/\u62a5\u9053<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;\">\u4eca\u65e5\uff0cNektar Therapeutics\u516c\u53f8\u5ba3\u5e03\u7f8e\u56fdFDA\u5df2\u7ecf\u63a5\u53d7\u4e86\u8be5\u516c\u53f8\u4e3aNKTR-181\u63d0\u4ea4\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\uff08NDA\uff09\u3002<\/span><\/strong><span style=\"font-size: 15px;\">NKTR-181\u662f\u8be5\u516c\u53f8\u7814\u53d1\u7684first-in-class\u963f\u7247\u7c7b\uff08opioid\uff09\u5206\u5b50\uff0c\u5b83\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u672a\u63a5\u53d7\u8fc7\u963f\u7247\u7c7b\u836f\u7269\u6cbb\u7597\u7684\u6210\u5e74\u6162\u6027\u8170\u75db\u60a3\u8005\u3002NKTR-181\u7684\u72ec\u7279\u5206\u5b50\u7ed3\u6784\u80fd\u591f\u663e\u8457\u51cf\u5c11\u8be5\u5206\u5b50\u8fdb\u5165\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u7684\u673a\u7387\uff0c\u4ece\u800c\u51cf\u5c11\u60a3\u8005\u5bf9\u836f\u7269\u4e0a\u763e\u7684\u98ce\u9669\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533787349.png\" alt=\"\u901f\u9012 | \u663e\u8457\u51cf\u5c11\u4e0a\u763e\u98ce\u9669\uff0c\u65b0\u578b\u6b62\u75bc\u836f\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\" title=\"\u901f\u9012 | \u663e\u8457\u51cf\u5c11\u4e0a\u763e\u98ce\u9669\uff0c\u65b0\u578b\u6b62\u75bc\u836f\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\"  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u75bc\u75db\u662f\u4eba\u4eec\u5bfb\u627e\u836f\u7269\u6cbb\u7597\u6700\u5e38\u89c1\u7684\u539f\u56e0\u4e4b\u4e00\uff0c\u800c\u8170\u75db\u662f\u5728\u7f8e\u56fd\u6210\u5e74\u4eba\u4e2d\u5bfc\u81f4\u6b8b\u75be\u7684\u7b2c\u4e8c\u5927\u539f\u56e0\u3002\u963f\u7247\u7c7b\u836f\u7269\u88ab\u8ba4\u4e3a\u662f\u6cbb\u7597\u75bc\u75db\u6700\u6709\u6548\u7684\u65b9\u6cd5\u4e4b\u4e00\u3002<strong>\u867d\u7136\u5b83\u80fd\u591f\u663e\u8457\u51cf\u8f7b\u75bc\u75db\uff0c\u4f46\u662f\u963f\u7247\u7c7b\u836f\u7269\u540c\u65f6\u9776\u5411\u5927\u8111\u4e2d\u7684\u591a\u5df4\u80fa\u5956\u52b1\u7cfb\u7edf\uff0c\u8ba9\u60a3\u8005\u4ea7\u751f\u6b23\u60a6\u7b49\u7cbe\u795e\u75c7\u72b6\u3002\u8fd9\u662f\u5bfc\u81f4\u60a3\u8005\u4e0a\u763e\u548c\u6ee5\u7528\u963f\u7247\u7c7b\u836f\u7269\u7684\u4e3b\u8981\u539f\u56e0\u3002<\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">Nektar\u516c\u53f8\u5f00\u53d1\u7684NKTR-181\u662f\u4e00\u79cd\u957f\u6548\u7684\u7279\u5f02\u6027\u03bc-\u963f\u7247\u7c7b\u53d7\u4f53\u7684\u6fc0\u52a8\u5242\u3002<strong>\u5b83\u7684\u72ec\u7279\u5206\u5b50\u7ed3\u6784\u8bbe\u8ba1\u964d\u4f4e\u4e86NKTR-181\u6e17\u900f\u8840\u8111\u5c4f\u969c\u7684\u80fd\u529b\uff0c\u4ece\u800c\u5ef6\u7f13\u4e86\u8be5\u836f\u7269\u8fdb\u5165\u5927\u8111\u7684\u901f\u5ea6\uff0c\u56e0\u800c\u51cf\u5f31\u4e86\u5927\u8111\u91ca\u653e\u591a\u5df4\u80fa\u7684\u901f\u5ea6\u3002<\/strong>\u8fd9\u8ba9NKTR-181\u5728\u7ef4\u6301\u957f\u6548\u9547\u75db\u6548\u5e94\u7684\u540c\u65f6\uff0c\u51cf\u5c11\u56e0\u4e3a\u9776\u5411CNS\u5f15\u8d77\u7684\u6b23\u60a6\u7b49\u526f\u4f5c\u7528\uff0c\u964d\u4f4e\u4e86\u60a3\u8005\u4e0a\u763e\u7684\u98ce\u9669\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(255, 255, 255);\">\u672c\u6587\u6765\u6e90\uff1a\u836f\u660e\u5eb7\u5fb7<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">NKTR-181\u4e0e\u5176\u5b83\u9632\u6b62\u4e0a\u763e\u7684\u963f\u7247\u7c7b\u836f\u7269\u7684\u533a\u522b\u662f\u5b83\u662f\u4e00\u79cd\u521b\u65b0\u7684\u5206\u5b50\u7ed3\u6784\uff0c\u800c\u4e0d\u4f9d\u8d56\u4e8e\u836f\u7269\u914d\u65b9\u4e0a\u7684\u6539\u53d8\u3002\u5b83\u7684\u4f18\u70b9\u5728\u4e8e\u60a3\u8005\u65e0\u6cd5\u901a\u8fc7\u81ea\u5df1\u6539\u53d8\u836f\u7269\u914d\u65b9\u7684\u65b9\u6cd5\u52a0\u5f3a\u8be5\u836f\u7269\u7684\u4e0a\u763e\u6548\u679c\u3002<strong>\u7f8e\u56fdFDA\u5df2\u7ecf\u6388\u4e88NKTR-181\u5feb\u901f\u901a\u9053\u8d44\u683c\u3002<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\"><strong><br  \/><\/strong><\/span><\/p>\n<p style=\"text-align: center;\">\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">Nektar \u516c\u53f8\u672c\u6b21\u9012\u4ea4\u7684NDA\u7533\u8bf7\u662f\u57fa\u4e8e\u5e7f\u6cdb\u7684\u4e34\u5e8a\u548c\u975e\u4e34\u5e8a\u6570\u636e\u3002\u4e34\u5e8a\u6570\u636e\u5305\u62ec15\u9879\u603b\u8ba1\u5305\u542b2234\u540d\u60a3\u8005\u7684\u4e0d\u540c\u7814\u7a76\u3002\u5176\u4e2d\u5305\u62ec\u5305\u542b600\u540d\u4e2d\u5ea6\u6216\u91cd\u5ea6\u6162\u6027\u8170\u75db\u60a3\u8005\u7684\u4e34\u5e8a3\u671f\u8bd5\u9a8c\u3002<strong>\u5728\u68c0\u6d4bNKTR-181\u9547\u75db\u7597\u6548\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cNKTR-181\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u5c06\u60a3\u8005\u7684\u75bc\u75db\u8bc4\u5206\u964d\u4f4e\u4e8665\uff05\u4ee5\u4e0a\uff08p=0.0019\uff09\u3002\u800c\u5728\u68c0\u6d4bNKTR-181\u4e0a\u763e\u98ce\u9669\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cNKTR-181\u4e0e\u5e38\u7528\u963f\u7247\u7c7b\u836f\u7269\u76f8\u6bd4\uff0c\u4e0a\u763e\u98ce\u9669\u663e\u8457\u964d\u4f4e\uff08p&lt;0.0001)\u3002<\/strong>\u5373\u4f7f\u4f7f\u7528\u8d85\u8fc7\u5e38\u7528\u6cbb\u7597\u5242\u91cf\u7684NKTR-181\uff0c\u5b83\u7684\u4e0a\u763e\u98ce\u9669\u4ecd\u7136\u6bd4\u6cbb\u7597\u5242\u91cf\u7684\u5e38\u7528\u963f\u7247\u7c7b\u836f\u7269\u4f4e\uff08p=0.0071\uff09\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">FDA\u9884\u8ba1\u57282019\u5e745\u670828\u65e5\u524d\u5bf9\u8be5\u836f\u7269\u80fd\u5426\u4e0a\u5e02\u4f5c\u51fa\u51b3\u5b9a\u3002\u8ba9\u6211\u4eec\u9884\u795d\u8fd9\u6b3e\u521b\u65b0\u836f\u7269\u65e9\u65e5\u83b7\u5f97\u6279\u51c6\uff0c\u4e3a\u6162\u6027\u8170\u75db\u60a3\u8005\u9020\u798f\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[1] Nektar Therapeutics Announces New Drug Application for NKTR-181 Accepted for Review by FDA<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 10px;color: rgb(178, 178, 178);\">[2] NKTR-181\u5b98\u65b9\u4ecb\u7ecd<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);line-height: normal;\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;word-wrap: break-word !important;\">\u672c\u6587\u6765\u81ea\u836f\u660e\u5eb7\u5fb7\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"__bg_gif\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533787349.gif\" alt=\"\u901f\u9012 | \u663e\u8457\u51cf\u5c11\u4e0a\u763e\u98ce\u9669\uff0c\u65b0\u578b\u6b62\u75bc\u836f\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\" title=\"\u901f\u9012 | \u663e\u8457\u51cf\u5c11\u4e0a\u763e\u98ce\u9669\uff0c\u65b0\u578b\u6b62\u75bc\u836f\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\"  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u660e\u5eb7\u5fb7                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u258e\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053 \u4eca\u65e5\uff0cNektar Therapeutics\u516c\u53f8\u5ba3\u5e03\u7f8e\u56fdFDA\u5df2\u7ecf\u63a5\u53d7\u4e86\u8be5\u516c\u53f8\u4e3aNKTR-1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":29560,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29559"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=29559"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29559\/revisions"}],"predecessor-version":[{"id":29567,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29559\/revisions\/29567"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/29560"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=29559"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=29559"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=29559"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}