{"id":29800,"date":"2018-08-05T01:00:00","date_gmt":"2018-08-09T04:03:54","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e5%be%ae%e7%8e%af%e5%a2%83%ef%bc%9a%e5%85%b3%e4%ba%8eph%e8%b0%83%e8%8a%82%e5%89%82%e5%af%b9%e5%bc%b1%e7%a2%b1%e6%80%a7%e8%8d%af%e7%89%a9%e9%87%8a%e6%94%be%e5%bd%b1%e5%93%8d%e7%9a%84%e7%a0%94%e7%a9%b6\/"},"modified":"2018-08-09T12:03:57","modified_gmt":"2018-08-09T04:03:57","slug":"%e5%be%ae%e7%8e%af%e5%a2%83%ef%bc%9a%e5%85%b3%e4%ba%8eph%e8%b0%83%e8%8a%82%e5%89%82%e5%af%b9%e5%bc%b1%e7%a2%b1%e6%80%a7%e8%8d%af%e7%89%a9%e9%87%8a%e6%94%be%e5%bd%b1%e5%93%8d%e7%9a%84%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/29800\/","title":{"rendered":"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><img class=\"__bg_gif\"     width=\"auto\" style=\"font-size: 16px;white-space: normal;color: rgb(62, 62, 62);line-height: 1.75em;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533787435.gif\" alt=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\" title=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\"  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u5bf9\u4e8e\u5f31\u78b1\u6027\u836f\u7269\u800c\u8a00\uff0c\u5982\u679c\u5c06\u5176\u5236\u6210\u7f13\u63a7\u91ca\u5236\u5242\uff0c\u5176\u6eb6\u89e3\u5ea6\u5177\u6709pH\u4f9d\u8d56\u6027\u7684\u7279\u70b9\u4f1a\u4ea7\u751f\u6eb6\u89e3\u5ea6\u4f4e\u4e14\u836f\u7269\u6700\u7ec8\u6eb6\u51fa\u91cf\u4e0d\u5b8c\u5168\u7684\u7279\u70b9\uff0c\u56e0\u4e3a\u5728\u6574\u4e2a\u80c3\u80a0\u9053\u7cfb\u7edf\u4e2d\uff0c\u5927\u90e8\u5206pH\u503c\u76f8\u5bf9\u504f\u9ad8\uff0c\u4e14\u836f\u7269\u5728\u80a0\u9053\u4e2d\u7684\u6ede\u7559\u65f6\u95f4\u8fdc\u957f\u4e8e\u5728\u80c3\u4e2d\u6ede\u7559\u7684\u65f6\u95f4\uff0c\u56e0\u6b64\uff0c\u5982\u679c\u8fd9\u4e2a\u95ee\u9898\u4e0d\u53bb\u89e3\u51b3\uff0c\u5219\u53ef\u80fd\u5bfc\u81f4\u6700\u7ec8\u7684\u836f\u7269\u5728\u4e2a\u4f53\u5185\u3001\u4e2a\u4f53\u95f4\u5b58\u5728\u8f83\u5927\u7684\u751f\u7269\u5229\u7528\u5ea6\u5dee\u5f02\u3002<\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;\">\n<section style=\"border-width: 8px 1px 1px;border-style: solid;border-color: rgb(68, 120, 242) rgb(204, 204, 204) rgb(204, 204, 204);box-shadow: rgb(204, 204, 204) 0px 0px 8px 0px;box-sizing: border-box;\">\n<section style=\"font-size: 24px;padding: 5px 10px;box-sizing: border-box;\"><span style=\"font-family: Helvetica, Arial, sans-serif;font-size: 18px;\">\u89e3\u51b3\u63aa\u65bd<\/span><\/section>\n<section style=\"border-top: 1px solid rgb(204, 204, 204);padding: 10px;box-sizing: border-box;\">\n<section class=\"135brush\" style=\"font-size: 14px;\">\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8f93<span style=\"font-family: Helvetica, Arial, sans-serif;caret-color: red;\">\u5bf9\u4e8e\u5f31\u78b1\u6027\u836f\u7269\u7684\u7f13\u63a7\u91ca\u5236\u5242\u800c\u8a00\uff0c\u76ee\u524d\u4e3b\u8981\u6709\u4e24\u79cd\u65b9\u6cd5\u53ef\u5c06\u5176\u53d8\u6210\u975epH\u4f9d\u8d56\u578b\u91ca\u653e\u7684\u5236\u5242\uff1a<\/span><\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u5904\u65b9\u4e2d\u589e\u52a0\u9178\u6027\u8f85\u6599\uff0c\u5373\u901a\u8fc7\u964d\u4f4e\u5fae\u73af\u5883pH\u503c\u6765\u63d0\u9ad8API\u7684\u5c40\u90e8\u6eb6\u89e3\u5ea6\uff0c\u5e76\u6700\u7ec8\u63d0\u9ad8\u836f\u7269\u7684\u91ca\u653e\u901f\u5ea6\uff1b<\/span><\/p>\n<\/li>\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u63d0\u9ad8\u5904\u65b9\u6574\u4f53\u7684\u6e17\u900f\u6027\uff0c\u4ee5\u6b64\u6765\u62b5\u6d88\u56e0\u4f53\u5185pH\u5347\u9ad8\u800c\u5bfc\u81f4\u6eb6\u89e3\u5ea6\u964d\u4f4e\u5e76\u6700\u7ec8\u9020\u6210\u4f53\u5185\u5438\u6536\u5dee\u5f02\u3002<\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"font-family: Helvetica, Arial, sans-serif;font-size: medium;line-height: 1.75em;\"><span style=\"font-size: 15px;\">\u8fd9\u4e24\u79cd\u65b9\u6cd5\u4e2d\uff0c\u7b2c\u4e8c\u79cd\u901a\u8fc7\u63d0\u9ad8\u6e17\u900f\u6027\u7684\u65b9\u6cd5\u66f4\u5e38\u7528\uff0c\u4e00\u822c\u662f\u901a\u8fc7\u589e\u52a0\u80a0\u6eb6\u6027\u805a\u5408\u7269(\u5982Eudragit L100-55)\uff0c\u8fd9\u6837\uff0c\u80a0\u6eb6\u6027\u805a\u5408\u7269\u5728\u4f4epH\u503c\u6761\u4ef6\u4e0b\u80fd\u901a\u8fc7\u5f62\u6210\u4e00\u79cd\u5c4f\u969c\u800c\u6291\u5236\u836f\u7269\u7684\u6eb6\u51fa\uff0c\u800c\u836f\u7269\u5728pH\u503c\u8f83\u9ad8\u7684\u80a0\u9053\u73af\u5883\u4e2d\u5176\u6574\u4f53\u7684\u6e17\u900f\u6027\u53c8\u5f97\u4ee5\u63d0\u9ad8\uff0c\u6700\u7ec8\u4f7f\u5f97\u836f\u7269\u7684\u91ca\u653e\u884c\u4e3a\u4e0d\u53d7pH\u7684\u5f71\u54cd\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"RankEditor\" style=\"border-width: 0px;border-style: none;border-color: initial;margin-top: 20px;\">\n<section style=\"border-width: 0px;border-style: none;border-color: initial;\">\n<section style=\"clear: both;border-width: 0px;border-style: none;border-color: initial;margin-bottom: 0.5em;\">\n<section class=\"white\" style=\"border-top: 2px solid rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-bottom-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(255, 255, 255);\">\n<section style=\"padding-right: 0.5em;padding-left: 0.5em;background-color: rgb(68, 120, 242);display: inline-block;\">\n<p class=\"brush\" style=\"min-width:1em;\"><span style=\";\">\u6848\u4f8b\u5206\u6790<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 82, 255);font-size: 16px;\"><strong>\u836f\u7269\u9009\u62e9\u2014\u2014\u7532\u6c27\u5627\u5576\u7f13\u91ca\u7247<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u7532\u6c27\u5627\u5576\u662f\u4e00\u79cd\u5f31\u78b1\u6027\u836f\u7269\uff0cpKa\u4e3a6.6\uff0c\u5728\u9178\u6027\u4ecb\u8d28\u4e2d\u6eb6\u89e3\u5ea6\u8f83\u9ad8(pH5.5\u4e2d\u6eb6\u89e3\u5ea6\u7ea6\u4e3a15.5 mg\/ml)\uff0c\u968f\u7740pH\u503c\u5347\u9ad8\uff0c\u5176\u6eb6\u89e3\u5ea6\u6025\u5267\u4e0b\u964d\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u7532\u6c27\u5627\u5576\u7f13\u91ca\u7247\u4e2dAPI\u542b\u91cf\u4e3a100 mg\uff0c\u7247\u91cd\u4e3a250 mg\uff1b\u9664\u6b64\u4e4b\u5916\uff0c\u5904\u65b9\u4e2d\u8fd8\u6709\u4eb2\u6c34\u6027\u51dd\u80f6\u9aa8\u67b6\u6750\u6599HPMC E4M(\u5360\u6bd425%w\/w)\u3001\u4e00\u6c34\u4e73\u7cd6\u3001\u5fae\u7c89\u7845\u80f6\u548c\u786c\u8102\u9178\u9541\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 82, 255);font-size: 16px;\"><strong>\u4f53\u5916\u6eb6\u51fa\u65b9\u6cd5<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u4f53\u5916\u6eb6\u51fa\u65b9\u6cd5\u9009\u62e9\u7684\u4e3aUSP-II\u6cd5\u6868\u6cd5\uff0c\u6eb6\u51fa\u4ecb\u8d28\u4e3a0.1 N HCl\u3001pH4.5\u78f7\u9178\u76d0\u3001pH6.8\u78f7\u9178\u76d0\u4e09\u79cd\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 82, 255);font-size: 16px;\"><strong>pH\u8c03\u8282\u5242\u7684\u9009\u62e9<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">pH\u8c03\u8282\u5242\u53ef\u4ee5\u4e3a\u9ad8\u5206\u5b50\u805a\u5408\u7269\uff0c\u4e5f\u53ef\u4ee5\u4e3a\u4f4e\u5206\u5b50\u6709\u673a\u5316\u5408\u7269\u3002\u672c\u6b21\u7814\u7a76\u5185\u5bb9\u4e2d\u7684\u9ad8\u5206\u5b50\u805a\u5408\u7269\u4e3aEudragit L100-55\uff0c\u5b83\u4e3b\u8981\u662f\u901a\u8fc7\u6291\u5236\u836f\u7269\u5728\u9178\u4ecb\u8d28\u4e2d\u7684\u6eb6\u51fa\uff0c\u540c\u65f6\u63d0\u9ad8\u836f\u7269\u6574\u4f53\u7684\u6e17\u900f\u6027\u800c\u8fbe\u5230\u6700\u7ec8\u836f\u7269\u4e0d\u53d7pH\u4f9d\u8d56\u7684\u91ca\u653e\u884c\u4e3a\uff1b\u4f4e\u5206\u5b50\u6709\u673a\u5316\u5408\u7269\u4e3a\u82f9\u679c\u9178\u3001\u67e0\u6aac\u9178\u3001\u67e0\u6aac\u9178\u4ee5\u53ca\u7425\u73c0\u9178\uff0c\u5b83\u4eec\u4e3b\u8981\u662f\u901a\u8fc7\u964d\u4f4e\u5fae\u73af\u5883pH\u503c\u800c\u63d0\u9ad8\u836f\u7269\u7684\u6eb6\u89e3\u5ea6\uff0c\u6700\u7ec8\u4f7f\u836f\u7269\u8fbe\u5230\u4e0d\u53d7pH\u4f9d\u8d56\u7684\u91ca\u653e\u884c\u4e3a\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 82, 255);font-size: 16px;\"><strong>\u4e0d\u52a0pH\u8c03\u8282\u5242\u7684\u6eb6\u51fa\u66f2\u7ebf<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u4e0b\u56fe1\u662f\u5904\u65b9\u4e2d\u4e0d\u52a0pH\u8c03\u8282\u5242\u7684\u7532\u6c27\u5627\u5576\u7f13\u91ca\u7247\u57280.1 N HCl\u3001pH4.5\u548cpH6.8\u4e2d\u7684\u6eb6\u51fa\u66f2\u7ebf\uff1a<\/span><\/p>\n<p style=\"text-align: center;line-height: normal;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress0-1533787435.png\" alt=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\" title=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\"  \/><\/p>\n<p style=\"text-align: center;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 14px;\">\u56fe1 &nbsp;\u4e0d\u52a0pH\u8c03\u8282\u5242\u7684\u7532\u6c27\u5627\u5576\u7f13\u91ca\u7247\u5728\u4e09\u79cd\u4ecb\u8d28\u4e2d\u7684\u6eb6\u51fa\u66f2\u7ebf<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u53ef\u663e\u8457\u770b\u51fa\uff0c\u836f\u7269\u7684\u91ca\u653e\u884c\u4e3a\u53d7\u4ecb\u8d28pH\u503c\u7684\u5f71\u54cd\u8f83\u5927\uff0c12 h\u65f6pH1.2\u7684\u91ca\u653e\u91cf\u8fbe\u5230\u4e8688%\uff0c\u4f46pH6.8\u4e2d\u7684\u4ec5\u4e3a39%\uff1b\u8ba1\u7b97pH1.2\u548cpH6.8\u4e4b\u95f4\u7684f2\u503c\u4ec5\u4e3a25.1\uff0c\u8fdb\u4e00\u6b65\u8868\u9762\u836f\u7269\u7684\u91ca\u653e\u53d7\u4ecb\u8d28pH\u503c\u5f71\u54cd\u8f83\u5927\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 82, 255);font-size: 16px;\"><strong>\u9ad8\u5206\u5b50\u805a\u5408\u7269L100-55<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u6709\u7814\u7a76\u8868\u9762\uff0c\u5728\u5904\u65b9\u4e2d\u589e\u52a0\u80a0\u6eb6\u6027\u805a\u5408\u7269\uff0c\u80fd\u901a\u8fc7\u5728\u836f\u7269\u8868\u9762\u5f62\u6210\u96be\u6eb6\u6027\u819c\u800c\u964d\u4f4e\u5f31\u78b1\u6027\u836f\u7269\u5728\u9178\u6027\u4ecb\u8d28\u4e2d\u7684\u6eb6\u51fa\u901f\u7387\uff0c\u540c\u65f6\uff0c\u80fd\u901a\u8fc7\u63d0\u9ad8\u6e17\u900f\u6027\u4f5c\u7528\u800c\u63d0\u9ad8\u836f\u7269\u5728\u9ad8pH\u6761\u4ef6\u4e2d\u7684\u6eb6\u51fa\u901f\u7387\uff0c\u6700\u7ec8\u8fbe\u5230\u836f\u7269\u7684\u91ca\u653e\u884c\u4e3a\u4e0d\u4f9d\u8d56\u4ecb\u8d28\u7684pH\u503c\u7684\u76ee\u7684\u3002\u4ee5L100-55\u4e3a\u4f8b\uff0c\u5728\u5904\u65b9\u4e2d\u52a0\u5165\u540e\uff0c\u5176\u5728\u4e09\u79cd\u4ecb\u8d28\u7684\u6eb6\u51fa\u66f2\u7ebf\u56fe\u5982\u4e0b\uff1a<\/span><\/p>\n<p style=\"text-align: center;line-height: normal;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress6-1533787435.png\" alt=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\" title=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\"  \/><\/p>\n<p style=\"text-align: center;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 14px;\">\u56fe2 &nbsp;\u589e\u52a030%w\/w L100-55\u7684\u7532\u6c27\u5627\u5576\u7f13\u91ca\u7247\u5728\u4e09\u79cd\u4ecb\u8d28\u4e2d\u7684\u6eb6\u51fa\u66f2\u7ebf<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u5bf9\u6bd4\u56fe1\u4e0e\u56fe2\uff0c\u5904\u65b9\u4e2d\u589e\u52a030%w\/w L100-55\u540e\uff0cpH6.8\u4ecb\u8d28\u4e2d\u7684\u91ca\u653e\u51e0\u4e4e\u6ca1\u6709\u4ec0\u4e48\u589e\u52a0\uff0c\u4f46pH1.2\u4ecb\u8d28\u4e2d\u5219\u662f\u6709\u964d\u4f4e\u7684\u3002\u91cd\u65b0\u8ba1\u7b97pH1.2\u548cpH6.8\u4e4b\u95f4\u7684f2\u503c\u4e3a38.0\uff0c\u8f83\u672a\u52a0\u524d\u768425.1\u8981\u597d\uff0c\u8bf4\u660eEudragitL100-55\u6709\u5229\u4e8e\u964d\u4f4e\u836f\u7269\u91ca\u653e\u884c\u4e3a\u53d7pH\u503c\u7684\u4f9d\u8d56(\u867d\u7136\u6700\u7ec8\u4e3a\u6210\u4e3apH\u4e0d\u4f9d\u8d56\u578b)\uff0c\u800c\u8fd9\u4e3b\u8981\u5f52\u529f\u4e8e\u836f\u7269\u5728\u80c3\u4e2d(pH1.2\u4ecb\u8d28)\u7684\u6eb6\u51fa\u53d7\u6291\u5236\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u9664\u6b64\u4e4b\u5916\uff0c\u672c\u7814\u7a76\u8fd8\u7814\u7a76\u4e86\u4e0d\u540c\u6bd4\u4f8bL100-55\u7684\u5904\u65b9\u7684\u5fae\u73af\u5883pH\u503c\uff0c\u89c1\u56fe3\u3002<\/span><\/p>\n<p style=\"text-align: center;line-height: normal;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress1-1533787435.png\" alt=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\" title=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\"  \/><\/p>\n<p style=\"text-align: center;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 14px;\">\u56fe3 &nbsp;\u4e0d\u540c\u6bd4\u4f8bEudragit L100-55\u7684\u5904\u65b9\u5fae\u73af\u5883\u53d8\u5316<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u4ece\u4e0a\u56fe\u53ef\u770b\u51fa\uff0cL100-55\u7528\u91cf\u4ece0%w\/w\u589e\u52a0\u81f330%\u65f6\uff0c\u5176\u5fae\u73af\u5883pH\u503c\u75316.8\u964d\u81f34.5\uff0c\u56e0\u6b64\uff0c\u968f\u7740\u5904\u65b9\u4e2dL100-55\u7528\u91cf\u7684\u589e\u52a0\uff0c\u5bf9pH6.8\u4ecb\u8d28\u4e2d\u7684\u6eb6\u51fa\u662f\u6709\u4fc3\u8fdb\u4f5c\u7528\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 82, 255);font-size: 16px;\"><strong>\u4f4e\u5206\u5b50\u6709\u673a\u5316\u5408\u7269<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u4f7f\u7528L100-55\u6700\u7ec8\u6ca1\u80fd\u5f97\u5230\u671f\u671b\u7684\u6eb6\u51fa\u975epH\u4f9d\u8d56\u578b\u91ca\u653e\u7684\u5236\u5242\uff0c\u4e8e\u662f\uff0c\u8fdb\u4e00\u6b65\u7814\u7a76\u4e86\u51e0\u79cd\u9178\u6027\u4f4e\u5206\u5b50\u6709\u673a\u5316\u5408\u7269\uff1a\u67e0\u6aac\u9178\u3001\u82f9\u679c\u9178\u3001\u7425\u73c0\u9178\u3001\u5bcc\u9a6c\u9178\uff0c\u5176\u7406\u5316\u6027\u8d28\u5982\u56fe4\u3002<\/span><\/p>\n<p style=\"text-align: center;line-height: normal;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533787436.png\" alt=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\" title=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\"  \/><\/p>\n<p style=\"text-align: center;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 14px;\">\u56fe4 &nbsp;\u51e0\u79cd\u9178\u6027\u4f4e\u5206\u5b50\u6709\u673a\u5316\u5408\u7269\u7684\u7406\u5316\u6027\u8d28<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u4e0e\u524d\u671f\u9009\u7528L100-55\u7528\u91cf\u4fdd\u6301\u4e00\u81f4\uff0c\u4f4e\u5206\u5b50\u6709\u673a\u5316\u5408\u7269\u7684\u7528\u91cf\u4ecd\u900930%w\/w\u3002\u5176\u5728pH1.2\u548cpH6.8\u4e2d\u7684\u6eb6\u51fa\u66f2\u7ebf\u89c1\u56fe5\u3002<\/span><\/p>\n<p style=\"text-align: center;line-height: normal;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533787436.jpg\" alt=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\" title=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\"  \/><\/p>\n<p style=\"text-align: center;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 14px;\">\u56fe5 &nbsp;\u56db\u79cd\u9178\u6027\u4f4e\u5206\u5b50\u6709\u673a\u5316\u5408\u7269\u4f5c\u4e3apH\u8c03\u8282\u5242\u5bf9\u5e94\u7684\u6eb6\u51fa\u66f2\u7ebf<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u4ece\u56fe5\u7684\u6eb6\u51fa\u66f2\u7ebf\u56fe\u53ef\u770b\u51fa\uff0c\u9664\u4e86d\u56fe\u7684\u7425\u73c0\u9178\u5916\uff0c\u5176\u4f59\u4e09\u79cdpH\u8c03\u8282\u5242\u589e\u52a0\u540e\u7684\u5904\u65b9\u5747\u5728pH6.8\u4ecb\u8d28\u4e2d\u7684\u6eb6\u51fa\u91ca\u653e\u6709\u6240\u63d0\u9ad8\u3002\u91cd\u65b0\u8ba1\u7b97\u5206\u522b\u4ee5\u67e0\u6aac\u9178\u3001\u82f9\u679c\u9178\u3001\u7425\u73c0\u9178\u3001\u5bcc\u9a6c\u9178\u4e3apH\u8c03\u8282\u5242\u7684\u5904\u65b9\u5728pH1.2\u548cpH6.8\u4e2d\u7684f2\uff0c\u5206\u522b\u4e3a66.1\u300154.5\u300150.9\u300140.1\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u56de\u5230\u4e0a\u56fe4\u4e2d\u53ef\u53d1\u73b0\uff0c\u7425\u73c0\u9178\u7684pKa\u662f\u6700\u5927\u7684\uff0c<strong>pka\u4e0e\u5c0f\u5206\u5b50\u7684\u89e3\u79bb\u80fd\u529b\u6709\u5173\uff0cpKa\u8d8a\u5c0f\uff0c\u5176\u5728\u78b1\u6027\u6eb6\u6db2\u4e2d\u7684\u89e3\u79bb\u80fd\u529b\u8d8a\u5927the lower the pka, the greater the dissociation of the acid in thebasic media\uff1bpKa\u8d8a\u5927\u7684\u9178\u6027\u5206\u5b50\uff0c\u5176\u5bf9\u5fae\u73af\u5883\u7684\u9178\u6027\u4f5c\u7528\u8d8a\u5f31\u3002<\/strong>\u4e5f\u6709\u7814\u7a76\u8868\u660e\uff1a\u964d\u4f4e\u5f31\u78b1\u6027\u836f\u7269\u7684\u5fae\u73af\u5883pH\u503c\uff0c\u80fd\u6709\u6548\u63d0\u9ad8\u5176\u5728SIF\u4ecb\u8d28(SIF,Simulated Intestinal Fluid\uff0c\u542b\u80f0\u9176\u7684\u80a0\u6a21\u62df\u6db2)\u4e2d\u7684\u6eb6\u51fa\u3002 <\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u672c\u6b21\u7814\u7a76\u5185\u5bb9\u4e2d\u52a0pH\u8c03\u8282\u5242\u548c\u4e0d\u52a0pH\u8c03\u8282\u5242(\u539f\u5904\u65b9)\u7684\u5fae\u73af\u5883pH\u503c\uff0c\u89c1\u56fe6\u3002<\/span><\/p>\n<p style=\"text-align: center;line-height: normal;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533787436.png\" alt=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\" title=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\"  \/><\/p>\n<p style=\"text-align: center;line-height: normal;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u56fe6 &nbsp;pH\u8c03\u8282\u5242\u6c34\u5e73\u5747\u4e3a30%w\/w\u65f6\u7684\u5fae\u73af\u5883pH\u503c<\/span><\/p>\n<p style=\"text-align: center;line-height: normal;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u6ce8\uff1a\u7b2c\u4e00\u4e2aLactose\u4e3a\u4e0d\u52a0pH\u8c03\u8282\u5242\u7684\u5904\u65b9\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u4ece\u56fe6\u4e2d\u53ef\u770b\u51fa\uff0c\u4e0d\u52a0pH\u8c03\u8282\u5242\uff0c\u4ea7\u54c1\u5fae\u73af\u5883PH\u503c\u63a5\u8fd16.8\uff0c\u52a0\u4e86\u5bcc\u9a6c\u9178Fumaric\u540e\u5fae\u73af\u5883pH\u503c\u5c06\u81f33.3\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u7ed3\u5408\u56fe4\u4e0e\u56fe6\u6211\u4eec\u8fd8\u53ef\u4ee5\u53d1\u73b0\uff0c\u82f9\u679c\u9178Malic\u4e0e\u67e0\u6aac\u9178Citric\u7684pka\u4e8b\u5b9e\u4e0a\u662f\u6bd4\u8f83\u63a5\u8fd1\u7684\uff0c\u4e14\u5176\u4e00\u7ea7\u89e3\u79bb\u80fd\u529b\u4e0e\u4e8c\u7ea7\u89e3\u79bb\u80fd\u529b\u6bd4\u8f83\u63a5\u8fd1(\u5206\u522b\u4e3a3.13\u4e0e3.4\u30014.76\u4e0e5.05)\uff0c\u4f46\u6700\u7ec8\u82f9\u679c\u9178Malic\u5374\u80fd\u4f7f\u5fae\u73af\u5883pH\u503c\u964d\u4f4e\u81f33.9\uff0c\u800c\u67e0\u6aac\u9178Citric\u5374\u53ea\u80fd\u964d\u4f4e\u81f34.9\uff0c\u9020\u6210\u8fd9\u79cd\u5dee\u5f02\u7684\u6216\u8bb8\u5c31\u662f\u5b83\u4eec\u4e4b\u95f4\u6eb6\u89e3\u5ea6\u7684\u5dee\u5f02\u4e86\uff0c\u82f9\u679c\u9178\u7684\u6eb6\u89e3\u5ea6\u4e3a0.6600 g\/ml\uff0c\u4f46\u67e0\u6aac\u9178\u53ea\u67091.1100 g\/ml\uff0c\u4e24\u8005\u6eb6\u89e3\u5ea6\u51e0\u4e4e\u76f8\u5dee\u4e24\u500d\uff0c\u6240\u4ee5\uff0c<strong>pH\u8c03\u8282\u5242\u672c\u8eab\u7684\u6eb6\u89e3\u5ea6\u4e5f\u80fd\u51b3\u5b9a\u5176\u5bf9\u5fae\u73af\u5883pH\u503c\u7684\u5f71\u54cd\u3002<\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 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href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA5MjEzODQ3NA==&amp;mid=2655761643&amp;idx=1&amp;sn=9b1c4defb2442eca2ff51feed6e0f544&amp;chksm=8bceaa6ebcb92378d3c9107540d37226e0d07188881050cba1b3ff44ac33d7e7ca1b8e8181cc&amp;scene=21#wechat_redirect\" target=\"_blank\"><span style=\"text-decoration: underline;font-size: 14px;\"><strong style=\"color: rgb(136, 136, 136);font-size: 14px;\">\u4ece\u4e8c\u7532\u57fa\u4e9a\u781c\u5230\u4f0f\u7acb\u8bfa\u4ed6\u2014\u2014\u9996\u4e2aHDAC\u6291\u5236\u5242\u7684\u7814\u53d1\u4e4b\u8def<\/strong><\/span><\/a><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA5MjEzODQ3NA==&amp;mid=2655756292&amp;idx=6&amp;sn=8ae873807e0f13e4eaaea32a11123559&amp;chksm=8bcebe81bcb9379718fa3f7c97699a16524969f4b74d9a3e1b46329a304786628bc806562b51&amp;scene=21#wechat_redirect\" target=\"_blank\"><span 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title=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\"  \/><\/p>\n<p style=\"text-align: center;\">\n<section class=\"RankEditor\" style=\"margin-top: 20px;\">\n<section style=\"display: inline-block;vertical-align: middle;width:12%;box-sizing: border-box;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;box-sizing: border-box;\"><img class=\"\"     style=\"box-sizing: border-box;font-size: 16px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress6-1533787436.gif\" alt=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\" title=\"\u5fae\u73af\u5883\uff1a\u5173\u4e8epH\u8c03\u8282\u5242\u5bf9\u5f31\u78b1\u6027\u836f\u7269\u91ca\u653e\u5f71\u54cd\u7684\u7814\u7a76\"  \/><\/section>\n<\/section>\n<section style=\"display:inline-block;width: 88%;padding:5px;box-sizing: border-box;vertical-align:middle;\">\n<p class=\"active brush\" style=\"box-sizing: border-box;font-size: 16px;color: rgb(121,121,121);min-width:1px;\"><span style=\"font-size: 15px;\">\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d,\u968f\u65f6\u638c\u63e1\u884c\u4e1a\u52a8\u6001<\/span><\/p>\n<\/section>\n<\/section>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u6e21                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5bf9\u4e8e\u5f31\u78b1\u6027\u836f\u7269\u800c\u8a00\uff0c\u5982\u679c\u5c06\u5176\u5236\u6210\u7f13\u63a7\u91ca\u5236\u5242\uff0c\u5176\u6eb6\u89e3\u5ea6\u5177\u6709pH\u4f9d\u8d56\u6027\u7684\u7279\u70b9\u4f1a\u4ea7\u751f\u6eb6\u89e3\u5ea6\u4f4e\u4e14\u836f\u7269\u6700\u7ec8\u6eb6\u51fa\u91cf\u4e0d\u5b8c\u5168\u7684 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":29801,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29800"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=29800"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29800\/revisions"}],"predecessor-version":[{"id":29816,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29800\/revisions\/29816"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/29801"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=29800"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=29800"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=29800"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}