{"id":29939,"date":"2018-08-02T01:00:00","date_gmt":"2018-08-09T04:04:45","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e6%af%8f%e6%97%a5%e4%b8%80%e8%8d%afataluren-translarna\/"},"modified":"2018-08-09T12:04:49","modified_gmt":"2018-08-09T04:04:49","slug":"%e6%af%8f%e6%97%a5%e4%b8%80%e8%8d%afataluren-translarna","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/29939\/","title":{"rendered":"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"__bg_gif\"    width=\"auto\"  style=\"color: rgb(62, 62, 62);font-size: 16px;line-height: 1.75em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533787486.gif\" alt=\"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae\" title=\"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae\"  \/><\/p>\n<section class=\"\" style=\"margin-top: 20px;max-width: 100%;color: rgb(51, 51, 51);\">\n<section style=\"max-width: 100%;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 0.5em;max-width: 100%;clear: both;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;border-top: 2px solid rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-bottom-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"padding-right: 0.5em;padding-left: 0.5em;max-width: 100%;background-color: rgb(68, 120, 242);display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;min-width: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\">\u57fa\u672c\u4fe1\u606f<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);line-height: 1.75em;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">Translarna\u00ae(Ataluren)\u662f\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40(EMA)\u4e8e2014\u5e747\u670831\u65e5\u6279\u51c6\u7684\u86cb\u767d\u8868\u8fbe\u4fee\u590d\u65b0\u836f\u3002\u8be5\u836f\u7531PTC Therepeutics\u516c\u53f8\u7814\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);line-height: 1.75em;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">Translarna\u00ae\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u548c\u808c\u8089\u840e\u7f29\u3002 Translarna\u00ae\u662f\u53e3\u670d\u9897\u7c92\u5242\uff0c\u6bcf\u5242\u5206\u522b\u542b125 mg\u3001250 mg\u30011000 mg Ataluren\uff0c\u63a8\u8350\u7ed9\u836f\u5242\u91cf\u6bcf\u59293\u6b21\uff0c\u65e9\u4e0a\u548c\u4e2d\u5348\u540410 mg\/kg\u3001\u665a\u4e0a20 mg\/kg \uff0c\u4f34\u968f\u6db2\u4f53\u548c\u534a\u56fa\u4f53\u9001\u670d\u3002<\/span><\/p>\n<section class=\"\" style=\"margin-top: 20px;max-width: 100%;color: rgb(51, 51, 51);\">\n<section style=\"max-width: 100%;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 0.5em;max-width: 100%;clear: both;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;border-top: 2px solid rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-bottom-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"padding-right: 0.5em;padding-left: 0.5em;max-width: 100%;background-color: rgb(68, 120, 242);display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;min-width: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7ed3\u6784\u5f0f<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 215px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress4-1533787486.png\" alt=\"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae\" title=\"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae\"  \/><\/p>\n<section class=\"\" style=\"margin-top: 20px;max-width: 100%;color: rgb(51, 51, 51);\">\n<section style=\"max-width: 100%;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 0.5em;max-width: 100%;clear: both;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;border-top: 2px solid rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-bottom-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"padding-right: 0.5em;padding-left: 0.5em;max-width: 100%;background-color: rgb(68, 120, 242);display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;min-width: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4f5c\u7528\u673a\u5236<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 466px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress4-1533787486.jpg\" alt=\"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae\" title=\"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);line-height: 1.75em;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f(DMD)\u60a3\u8005mRNA\u53d1\u751f\u65e0\u610f\u7a81\u53d8\u4ea7\u751f\u63d0\u524d\u7ec8\u6b62\u5bc6\u7801\u5b50\uff08premature stop codon\uff09\uff0c\u4f7fmRNA\u7ffb\u8bd1\u63d0\u524d\u7ec8\u6b62\uff0c\u4e0d\u80fd\u4ea7\u751f\u5b8c\u6574\u7684\u86cb\u767d\u3002 Translarna\u00ae\u80fd\u4f7f\u6838\u7cd6\u4f53\u7ffb\u8bd1\u542b\u63d0\u524d\u7ec8\u6b62\u5bc6\u7801\u5b50mRNA\uff0c\u4f7f\u542b\u63d0\u524d\u7ec8\u6b62\u5bc6\u7801\u5b50\u7684mRNA\u80fd\u8868\u8fbe\u5b8c\u6574\u86cb\u767d\u8d28\u3002<\/span><\/p>\n<section class=\"\" style=\"margin-top: 20px;max-width: 100%;color: rgb(51, 51, 51);\">\n<section style=\"max-width: 100%;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 0.5em;max-width: 100%;clear: both;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;border-top: 2px solid rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-bottom-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"padding-right: 0.5em;padding-left: 0.5em;max-width: 100%;background-color: rgb(68, 120, 242);display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;min-width: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5408\u6210\u8def\u7ebf<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;width: 0px;height: 0px;clear: both;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533787486.jpg\" alt=\"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae\" title=\"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae\"  \/><\/p>\n<\/section>\n<section class=\"\" style=\"margin-top: 20px;max-width: 100%;color: rgb(51, 51, 51);\">\n<section style=\"max-width: 100%;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 0.5em;max-width: 100%;clear: both;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;border-top: 2px solid rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-bottom-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"padding-right: 0.5em;padding-left: 0.5em;max-width: 100%;background-color: rgb(68, 120, 242);display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;min-width: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7814\u7a76\u5173\u952e\u6570\u636e<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><img class=\"\"           style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 558px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533787487.jpg\" alt=\"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae\" title=\"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae\"  \/><\/p>\n<section class=\"\" style=\"margin-top: 20px;max-width: 100%;color: rgb(51, 51, 51);\">\n<section style=\"max-width: 100%;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 0.5em;max-width: 100%;clear: both;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;border-top: 2px solid rgb(68, 120, 242);border-right-color: rgb(68, 120, 242);border-bottom-color: rgb(68, 120, 242);border-left-color: rgb(68, 120, 242);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"padding-right: 0.5em;padding-left: 0.5em;max-width: 100%;background-color: rgb(68, 120, 242);display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;min-width: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\">\u540c\u9776\u70b9\u5728\u7814\u53ca\u4e0a\u5e02\u836f\u7269<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533787487.jpg\" alt=\"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae\" title=\"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533787488.png\" alt=\"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae\" title=\"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae\"  \/><\/p>\n<p style=\"text-align: center;\">\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress3-1533787488.jpeg\" alt=\"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae\" title=\"\u6bcf\u65e5\u4e00\u836f||Ataluren\/Translarna\u00ae\"  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u6e21                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u57fa\u672c\u4fe1\u606f Translarna\u00ae(Ataluren)\u662f\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40(EMA)\u4e8e2014\u5e747\u670831\u65e5\u6279\u51c6\u7684\u86cb\u767d [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":29940,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29939"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=29939"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29939\/revisions"}],"predecessor-version":[{"id":29953,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/29939\/revisions\/29953"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/29940"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=29939"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=29939"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=29939"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}