{"id":29954,"date":"2018-08-01T01:00:00","date_gmt":"2018-08-09T04:04:50","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e5%90%ab%e6%b0%9f%e5%9f%ba%e5%9b%a2%e5%bc%95%e5%85%a5%e5%b0%8f%e7%bb%93\/"},"modified":"2018-08-09T12:04:53","modified_gmt":"2018-08-09T04:04:53","slug":"%e5%90%ab%e6%b0%9f%e5%9f%ba%e5%9b%a2%e5%bc%95%e5%85%a5%e5%b0%8f%e7%bb%93","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/29954\/","title":{"rendered":"\u542b\u6c1f\u57fa\u56e2\u5f15\u5165\u5c0f\u7ed3"},"content":{"rendered":"
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\"\u542b\u6c1f\u57fa\u56e2\u5f15\u5165\u5c0f\u7ed3\"<\/p>\n


<\/p>\n

\u7531\u4e8e\u6c1f\u539f\u5b50\u53ca\u542b\u6c1f\u57fa\u56e2\u7684\u7279\u6b8a\u6027\u8d28\uff0c\u4f7f\u5f97\u542b\u6c1f\u6709\u673a\u7269\u7684\u5e94\u7528\u8d8a\u6765\u8d8a\u591a\uff0c\u5728\u65b0\u836f\u7814\u53d1\u9886\u57df\u5e94\u7528\u4e5f\u662f\u6781\u5176\u5e7f\u6cdb\u3002\u9057\u61be\u7684\u662f\u81ea\u7136\u754c\u4e2d\u5929\u7136\u7684\u542b\u6c1f\u6709\u673a\u7269\u975e\u5e38\u5c11\u89c1\uff0c\u56e0\u6b64\u5411\u6709\u673a\u5206\u5b50\u4e2d\u9009\u62e9\u6027\u7684\u5f15\u5165\u6c1f\u539f\u5b50\u6216\u542b\u6c1f\u57fa\u56e2\u5bf9\u4e8e\u836f\u7269\/\u5408\u6210\u5316\u5b66\u5bb6\u6765\u8bf4\u5c31\u663e\u5f97\u975e\u5e38\u91cd\u8981\u3002\u7b14\u8005\u5c31\u542b\u6c1f\u57fa\u56e2\u7684\u5f15\u5165\u505a\u4e00\u4e2a\u7b80\u5355\u7684\u5c0f\u7ed3\uff0c\u5e0c\u671b\u53ef\u4ee5\u5728\u5927\u5bb6\u7684\u65e5\u5e38\u5408\u6210\u5b9e\u9a8c\u4e2d\u80fd\u6709\u70b9\u6ef4\u5e2e\u52a9\uff0c\u7b14\u8005\u5c31\u5f88\u6ee1\u8db3\u4e86\u3002\u76ee\u524d\u6c1f\u539f\u5b50\u7684\u5f15\u5165\u5927\u81f4\u53ef\u5206\u4e3a\u4e8c\u7c7b\u3002<\/span><\/p>\n


<\/span><\/p>\n

1\u3001\u76f4\u63a5\u6c1f\u5316\u6cd5\uff1a<\/span><\/strong><\/span>\u5373\u901a\u8fc7\u6c1f\u5316\u8bd5\u5242\u5c06\u6c1f\u539f\u5b50\u5f15\u5165\u5230\u6709\u673a\u5206\u5b50\u4e2d\uff0c\u4f46\u662f\u76f4\u63a5\u6c1f\u5316\u53cd\u5e94\u5267\u70c8\uff0c\u96be\u4ee5\u63a7\u5236\uff0c\u4e00\u822c\u53ea\u662f\u7406\u8bba\u4e0a\u7684\u65b9\u6cd5\uff0c\u5b9e\u9645\u5728\u5b9e\u9a8c\u5ba4\u5de5\u4f5c\u4e2d\u7528\u5230\u7684\u5f88\u5c11\u3002<\/span><\/p>\n


<\/span><\/p>\n

2\u3001\u542b\u6c1f\u780c\u5757\u6cd5\uff1a<\/span><\/strong><\/span>\u5373\u901a\u8fc7\u542b\u6c1f\u539f\u6599\u7684\u4eb2\u6838\/\u4eb2\u7535\u53d6\u4ee3\u7b49\u53cd\u5e94\u5f15\u5165\u6c1f\u539f\u5b50\u6216\u542b\u6c1f\u57fa\u56e2\u5230\u6709\u673a\u5206\u5b50\u4e2d\u5b9e\u73b0\u5206\u5b50\u542b\u6c1f\u5316\u7684\u8f6c\u5316\u3002<\/span>(\u6b64\u5b9a\u4e49\u662f\u7b14\u8005\u81ea\u5df1\u5b9a\u4e49\u7684\uff0c\u786e\u5207\u4e0e\u5426\uff0c\u671b\u8bfb\u8005\u81ea\u884c\u5224\u65ad)<\/span>\u8fd9\u79cd\u65b9\u6cd5\u4e00\u822c\u5177\u6709\u9009\u62e9\u6027\u597d\u3001\u53cd\u5e94\u6e29\u548c\u3001\u4ea7\u7387\u9ad8\u7b49\u4f18\u70b9\uff0c\u56e0\u6b64\u5728\u5b9e\u9645\u5de5\u4f5c\u4e2d\u4e5f\u662f\u6b64\u7c7b\u65b9\u6cd5\u5e94\u7528\u6700\u591a\uff0c\u6700\u53d7\u5316\u5b66\u5bb6\u7684\u9752\u7750\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u542b\u6c1f\u57fa\u56e2\u5f15\u5165\u5c0f\u7ed3\"<\/p>\n


<\/p>\n

\n
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\"\u542b\u6c1f\u57fa\u56e2\u5f15\u5165\u5c0f\u7ed3\"<\/section>\n
\n
<\/section>\n
\n
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\u5e38\u7528\u6c1f\u5316\u8bd5\u5242\u4f5c\u7528\u7b80\u4ecb<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n


<\/p>\n<\/section>\n<\/section>\n

1) Ishikawa \u8bd5\u5242\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\uff0c\u9009\u62e9\u6027\u9ad8\uff0c\u5206\u5b50\u4e2d\u7684\u73af\u6c27\u952e\u3001\u53cc\u952e\u3001\u4fdd\u62a4\u57fa\u4e0d\u53d7\u5f71\u54cd\uff1b\u80fd\u591f\u4e0e\u4f2f\u9187\u3001\u4ef2\u9187\u548c\u53d4\u9187\u53d1\u751f\u53d6\u4ee3\u53cd\u5e94\uff0c\u5176\u4e2d\u4f2f\u9187\u53cd\u5e94\u6027\u80fd\u6bd4\u8f83\u597d\uff0c\u4ef2\u9187\u548c\u53d4\u9187\u4f1a\u6709\u6d88\u9664\u6216\u5076\u8054\u7684\u526f\u4ea7\u7269\u4ea7\u751f\uff0c\u53cd\u5e94\u901a\u5e38\u5728\u4e59\u919a\u6216\u4e8c\u6c2f\u7532\u70f7\u4e2d\u8fdb\u884c\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u542b\u6c1f\u57fa\u56e2\u5f15\u5165\u5c0f\u7ed3\"<\/p>\n

Koch,G. et al. Synlett. 2004, 693<\/span><\/p>\n


<\/span><\/p>\n

2) DAST \u6c1f\u5316\u8bd5\u5242\u662f\u6db2\u4f53\uff0c\u5728\u5e72\u71e5\u5ba4\u6e29\u6761\u4ef6\u4e0b\u80fd\u591f\u957f\u671f\u4fdd\u5b58\uff0c\u6e29\u5ea6\u8d85\u8fc790\u2103 \u8be5\u8bd5\u5242\u4f1a\u5206\u89e3\uff0c\u5e76\u6709\u7206\u70b8\u7684\u5371\u9669\u3002DAST\u662f\u4f7f\u7528\u6700\u5e7f\u6cdb\u7684\u6c1f\u4ee3\u8bd5\u5242\u4e4b\u4e00\uff0c\u4f46\u7531\u4e8eDAST \u8bd5\u5242\u4f7f\u7528\u8d77\u6765\u64cd\u4f5c\u7b80\u5355\u3001\u901a\u7528\u6027\u5f3a\u3001\u9009\u62e9\u6027\u9ad8\uff0c\u80fd\u5c06\u7f9f\u57fa\u5316\u5408\u7269\u8f6c\u5316\u4e3a\u5355\u6c1f\u4ee3\u5316\u5408\u7269\uff0c\u919b\u548c\u916e\u8f6c\u5316\u4e3a\u4e8c\u6c1f\u4ee3\u5316\u5408\u7269\uff0c\u5bf9\u7fa7\u9178\u53ca\u5176\u884d\u751f\u7269\u7684\u7fb0\u57fa\u5219\u6ca1\u6709\u5f71\u54cd\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u542b\u6c1f\u57fa\u56e2\u5f15\u5165\u5c0f\u7ed3\"<\/p>\n

Tetrahedron. Lett. 2004,45, 1455<\/span><\/p>\n


<\/span><\/p>\n

3) Deoxo-fluor \u8bd5\u5242\u53ef\u7528\u4e8e\u591a\u79cd\u624b\u6027\u6709\u673a\u6c1f\u5316\u7269\u7684\u5408\u6210\uff0c\u4e14\u4fdd\u6301\u4ea7\u7269\u6784\u578b\u4e0d\u53d8\u3002\u8be5\u8bd5\u5242\u5728\u4e8c\u6c2f\u7532\u70f7\u6eb6\u5242\u4e2d\u5e38\u6e29\u4e0b\u5c31\u80fd\u5c06\u4e8c\u9187\u8f6c\u5316\u4e3a\u6c1f\u5316\u7269\uff0c\u8be5\u8bd5\u5242\u53cd\u5e94\u6761\u4ef6\u6e29\u548c\u3001\u6536\u7387\u9ad8\u3001\u56e0\u6b64\u5e7f\u6cdb\u5e94\u7528\u4e8e\u624b\u6027\u533b\u836f\u7684\u5236\u5907\u3002<\/span><\/p>\n


<\/span><\/p>\n

4) SF4\u662f\u6c1f\u4ee3\u80fd\u529b\u5f88\u5f3a\u7684\u4e00\u79cd\u8bd5\u5242\uff0c\u901a\u5e38\u548cHF\u4e00\u8d77\u4f7f\u7528\u3002\u9664\u4e86\u80fd\u628a\u7f9f\u57fa\u5316\u5408\u7269\u8f6c\u5316\u4e3a\u5355\u6c1f\u4ee3\u5316\u5408\u7269\uff0c\u919b\u548c\u916e\u8f6c\u5316\u4e3a\u4e8c\u6c1f\u4ee3\u5316\u5408\u7269\u4e4b\u5916\uff0c\u8fd8\u80fd\u628a\u7fa7\u57fa\u8f6c\u5316\u4e3a\u4e09\u6c1f\u7532\u57fa\uff0c\u662f\u5408\u6210\u4e09\u6c1f\u7532\u57fa\u5316\u5408\u7269\u7684\u4e00\u4e2a\u91cd\u8981\u65b9\u6cd5\uff0c\u7279\u522b\u662f\u82b3\u9999\u7c7b\u4e09\u6c1f\u7532\u57fa\u5316\u5408\u7269\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u542b\u6c1f\u57fa\u56e2\u5f15\u5165\u5c0f\u7ed3\"<\/p>\n


<\/p>\n

SF4\u5728\u6c1f\u5316\u5b66\u7684\u53d1\u5c55\u53f2\u4e0a\u662f\u5f88\u91cd\u8981\u7684\u4e00\u79cd\u6c1f\u4ee3\u8bd5\u5242\uff0c\u968f\u7740DAST\u7b49\u65b0\u578b\u6c1f\u4ee3\u8bd5\u5242\u7684\u53d1\u5c55\uff0cSF4\u5728\u6c1f\u5316\u5b66\u4e2d\u7684\u5e94\u7528\u9010\u6e10\u51cf\u5c11\uff0c\u5bf9\u7f9f\u57fa\u5316\u5408\u7269\u548c\u919b\u916e\u7684\u6c1f\u4ee3\u53cd\u5e94\u57fa\u672c\u5df2\u88abDAST\u7b49\u8bd5\u5242\u53d6\u4ee3\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u542b\u6c1f\u57fa\u56e2\u5f15\u5165\u5c0f\u7ed3\"<\/p>\n

\"\u542b\u6c1f\u57fa\u56e2\u5f15\u5165\u5c0f\u7ed3\"<\/p>\n


<\/p>\n

\u8bf4\u5230\u6c1f\u4ee3\u53cd\u5e94\uff0c\u4e09\u6c1f\u7532\u57fa\u7684\u6c1f\u4ee3\u5c31\u4e0d\u5f97\u4e0d\u63d0\u4e86\uff0c\u5176\u5728\u836f\u5316\u4e2d\u7684\u5e94\u7528\u771f\u7684\u662f\u975e\u5e38\u5e7f\u6cdb\u3002Lily\u5f00\u53d1\u7684\u6c1f\u897f\u6c40(Fluoxetine)\uff0c\u662f\u5168\u7403\u7b2c\u4e00\u4e2a\u4e0a\u5e02\u7684SSRIs\u6297\u6291\u90c1\u75c7\u836f\u7269\uff0c\u7531\u4e8e\u4e09\u6c1f\u7532\u57fa\u7684\u5f15\u5165\uff0c\u4f7f\u5176\u5177\u6709\u72ec\u7279\u7684\u836f\u7406\u6027\u8d28\u548c\u4e34\u5e8a\u7597\u6548\uff0c\u500d\u53d7\u533b\u751f\u60a3\u8005\u7684\u9752\u7750\u3002\u4e09\u6c1f\u7532\u57fa\u7684\u7279\u6027\u5982\u4e0b\uff1a<\/span><\/p>\n

1) \u4e09\u6c1f\u7532\u57fa\u662f\u6240\u6709\u53d6\u4ee3\u57fa\u4e2d\u4eb2\u8102\u6027\u6700\u5f3a\u7684\u57fa\u56e2\uff1b<\/span><\/p>\n

2) \u7531\u4e8e\u5176\u5f3a\u7535\u8d1f\u6027\u548c\u9ad8\u7a33\u5b9a\u6027\uff0c\u4f7f\u5f97\u4e09\u6c1f\u7532\u57fa\u5bf9\u5e95\u7269\u7684\u751f\u7269\u548c\u5316\u5b66\u8f6c\u5316\u7684\u533a\u57df\u9009\u62e9\u6027\u548c\u7acb\u4f53\u9009\u62e9\u6027\u65b9\u9762\u5f80\u5f80\u6709\u7740\u51b3\u5b9a\u6027\u7684\u4f5c\u7528\uff1b<\/span><\/p>\n

3) \u7279\u522b\u503c\u5f97\u63d0\u51fa\u7684\u662f\u76ee\u524d\u5f88\u591a\u542b\u6709\u4e09\u6c1f\u7532\u57fa\u7684\u6709\u673a\u5206\u5b50\u90fd\u5177\u6709\u91cd\u8981\u7684\u751f\u7406\u6d3b\u6027\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u6309\u7167\u53cd\u5e94\u673a\u7406\uff0c\u4e09\u6c1f\u7532\u57fa\u7684\u5f15\u5165\u4e3b\u8981\u5206\u4e3a\u4e09\u5927\u7c7b\uff1a\u81ea\u7531\u57fa\u4e09\u6c1f\u7532\u57fa\u5316\uff0c\u4eb2\u6838\u4e09\u6c1f\u7532\u57fa\u5316\u548c\u4eb2\u7535\u4e09\u6c1f\u7532\u57fa\u5316\u3002\u9274\u4e8e\u4e09\u6c1f\u7532\u57fa\u7684\u5f15\u5165\u662f\u4e00\u4e2a\u4e0d\u65ad\u66f4\u65b0\u8fdb\u6b65\u7684\u3001\u5e95\u7269\u7279\u6b8a\u6027\u8981\u6c42\u5f88\u9ad8\u7684\u53cd\u5e94\uff0c\u7b14\u8005\u5c31\u5217\u4e3e\u4e00\u4e9b\u6700\u8fd1\u66f4\u65b0\u7684\u5173\u4e8e\u4e09\u6c1f\u7532\u57fa\uff0c\u4e8c\u6c1f\u7532\u57fa\u5f15\u5165\u7684\u6587\u7ae0\uff0c\u6709\u5174\u8da3\u7684\u5c0f\u4f19\u4f34\u53ef\u81ea\u884c\u8c03\u9605\u3002<\/span><\/p>\n

<\/span><\/p>\n

\n
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\"\u542b\u6c1f\u57fa\u56e2\u5f15\u5165\u5c0f\u7ed3\"<\/section>\n<\/section>\n
\n

1\uff0cOrg. Chem. Front., 2016, 3, 150;<\/span><\/p>\n

2\uff0cJ. Org. Chem., 2016, 81, 3654;<\/span><\/p>\n

3\uff0cJ. Am. Chem. Soc. 140, 21, 6522-6526\uff1b<\/span><\/p>\n

4\uff0cAcc. Chem. Res. 51, 5, 1272-1280\uff1b<\/span><\/p>\n

5\uff0cAdv. Synth. Catal., 2017, 359, 384;<\/span><\/p>\n

6\uff0cChem. Commun., 2017, 53, 2222;<\/span><\/p>\n

7\uff0cOrg. Lett., 2018, 20, 393\uff1b<\/span><\/p>\n

8\uff0cNat. Commun. 2016, 7, 13320\uff1b<\/span><\/p>\n

9\uff0cOrg. Lett. 2016, 18,3754\uff0d3757\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n


<\/p>\n<\/section>\n<\/section>\n

<\/span><\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n

1, J. Am. Chem. Soc. 2001, 123, 6947-6948;<\/span><\/p>\n

2, Angew. Chem. Int. Ed. 2003, 42, 4762-4767;<\/span><\/p>\n

3, Fine and Specialty Chemicals, Sep.2013, 39;<\/span><\/p>\n

4, \u90e8\u5206\u5185\u5bb9\u6765\u6e90\u4e8e\u7f51\u7edc\u6536\u96c6\u3002<\/span><\/p>\n


<\/p>\n

\n
\n
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\u5f80\u671f\u7cbe\u5f69<\/span><\/strong><\/section>\n
\n

2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5<\/span><\/strong><\/span><\/a><\/h2>\n

\u5343\u547c\u4e07\u5524\u59cb\u51fa\u6765-Keytruda\u738b\u8005\u8bde\u751f\u4e4b\u8def<\/span><\/strong><\/span><\/a><\/h2>\n

\u809d\u764c\u6cbb\u7597\u836f\u7269\u7814\u7a76\u8fdb\u5c55(2018)<\/span><\/strong><\/span><\/a><\/h2>\n

2018\u5e74\u4e0a\u534a\u5e74\u6279\u51c6\u4e0a\u5e02\u7684\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u4e13\u9879\u54c1\u79cd<\/span><\/strong><\/span><\/a><\/h2>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\"\u542b\u6c1f\u57fa\u56e2\u5f15\u5165\u5c0f\u7ed3\"<\/span><\/a><\/p>\n

\"\u542b\u6c1f\u57fa\u56e2\u5f15\u5165\u5c0f\u7ed3\"<\/p>\n

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\"\u542b\u6c1f\u57fa\u56e2\u5f15\u5165\u5c0f\u7ed3\"<\/section>\n<\/section>\n
\n

\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d,\u968f\u65f6\u638c\u63e1\u884c\u4e1a\u52a8\u6001<\/span><\/p>\n<\/section>\n<\/section>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u836f\u6e21 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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