{"id":30013,"date":"2018-07-31T01:00:00","date_gmt":"2018-08-09T04:05:08","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/2018%e5%b9%b46%e6%9c%88%e5%85%a8%e7%90%83%e6%89%b9%e5%87%86%e6%96%b0%e8%8d%af%e6%a6%82%e5%86%b5\/"},"modified":"2018-08-09T12:05:15","modified_gmt":"2018-08-09T04:05:15","slug":"2018%e5%b9%b46%e6%9c%88%e5%85%a8%e7%90%83%e6%89%b9%e5%87%86%e6%96%b0%e8%8d%af%e6%a6%82%e5%86%b5","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/30013\/","title":{"rendered":"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><img class=\"__bg_gif\"     width=\"auto\" style=\"font-size: 16px;white-space: normal;color: rgb(62, 62, 62);line-height: 1.75em;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533787509.gif\" alt=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section>\n<section style=\"transform: rotate(0deg);-webkit-transform: rotate(0deg);-moz-transform: rotate(0deg);-ms-transform: rotate(0deg);-o-transform: rotate(0deg);\">\n<section style=\"padding-right: 2em;padding-left: 2em;transform: rotate(0deg);\">\n<section style=\"height: 3em;border-right: 2px solid rgb(122, 58, 144);border-left: 2px solid rgb(122, 58, 144);box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"display: flex;justify-content: space-between;align-items:flex-end;margin-top:-7px;\">\n<section style=\"margin-left:1.7em;\">\n<section   style=\"border-width: 2px;border-style: solid;border-color: rgb(122, 58, 144);width: 12px;height: 12px;background: rgb(236, 165, 235);border-radius: 100%;box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"margin-right:1.7em;\">\n<section   style=\"border-width: 2px;border-style: solid;border-color: rgb(122, 58, 144);width: 12px;height: 12px;background: rgb(236, 165, 235);border-radius: 100%;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 5px;padding-bottom: 20px;padding-left: 15px;margin-top: -10px;box-sizing: border-box;\">\n<section   style=\"border-width: 1px;border-style: solid;border-color: rgb(51, 51, 51);padding-bottom: 8px;border-radius: 5px;background-color: rgb(170, 229, 236);box-sizing: border-box;\">\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(51, 51, 51);padding: 20px 10px 10px;background-color: rgb(254, 254, 254);border-radius: 5px;margin-left: -10px;margin-top: -10px;margin-right: 10px;box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"text-align: justify;font-size: 14px;padding: 10px 5px;line-height: 1.75em;color: rgb(122, 58, 144);text-indent: 2em;box-sizing: border-box;\"><span style=\"font-family: Helvetica, Arial, sans-serif;font-size: 15px;\">2018\u5e746\u6708\uff0cFDA\u5171\u6279\u51c64\u4e2a\u65b0\u5206\u5b50\u5b9e\u4f53\uff08NME\uff09\u836f\u7269\uff0c\u5206\u522b\u662f\u6cbb\u7597\u76d8\u5c3e\u4e1d\u866b\u75c5\u7684\u83ab\u897f\u83cc\u7d20\uff08Moxidectin\uff09\u3001\u6cbb\u7597\u590d\u6742\u6027\u5c3f\u8def\u611f\u67d3\u7684Plazomicin Sulfate\u3001\u6cbb\u7597Lennox-Gastaut\u7efc\u5408\u5f81\u548cDravet\u7efc\u5408\u5f81\u7684\u5927\u9ebb\u4e8c\u915a\uff08Cannabidiol\uff09\u548c\u6cbb\u7597\u6076\u6027\u9ed1\u8272\u7d20\u7624\u7684\u8054\u5408\u7528\u836f\u7ec4\u5408Encorafenib\u3001Binimetinib\u3002CFDA\u6279\u51c61\u4e2a1\u7c7b\u65b0\u836f\uff0c\u662f\u6cbb\u7597\u4e19\u809d\u7684\u8fbe\u8bfa\u745e\u97e6\u94a0\uff08Danoprevir Sodium\uff09 \u30026\u6708\u65e0\u83b7\u6279\u7684\u65b0\u751f\u7269\u5236\u54c1\u3002<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533787509.jpg\" alt=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 16px;\"><strong><span style=\"color: rgb(0, 0, 0);\"><\/span><\/strong><\/span><br  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"text-align:center;\">\n<section style=\"width: 2.5em;height: 3em;color: rgb(255, 255, 255);font-size: 1em;line-height: 3em;display: inline-block;background-image: url('http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533787515.gif');background-repeat: no-repeat;background-size: 100%;background-position: 0px center;\">\n<p class=\"autonum\"  title=\"\">1<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 16px;\"><strong><span style=\"color: rgb(0, 0, 0);\">\u83ab\u897f\u83cc\u7d20(Moxidectin)<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"width: 187px;height: 170px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress6-1533787510.png\" alt=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u83ab\u897f\u83cc\u7d20\uff08Moxidectin\uff09\u6700\u521d\u7531\u60e0\u6c0f\uff08\u8f89\u745e\u5b50\u516c\u53f8\uff09\u548c\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\uff08WHO\uff09\u5408\u4f5c\u7814\u53d1\uff0c\u540e\u6765\u6388\u6743\u7ed9\u5168\u7403\u536b\u751f\u836f\u7269\u5f00\u53d1\uff08Medicines Developmentfor Global Health\uff0cMDGH\uff09\uff0c\u4e8e2018\u5e746\u670813\u65e5\u83b7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u4e0a\u5e02\uff0c\u7531MDGH\u4e0a\u5e02\u9500\u552e\uff0c\u5546\u54c1\u540d\u4e3aMoxidectin<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002Moxidectin<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u5e74\u9f84\u572812\u5c81\u53ca\u4ee5\u4e0a\u60a3\u8005\u7684\u76d8\u5c3e\u4e1d\u866b\u75c5\uff08\u6cb3\u76f2\u75c7\uff09<sup><span style=\"font-size:12px;font-family:\u5fae\u8f6f\u96c5\u9ed1,sans-serif;\">[1]<\/span><\/sup>\u3002\u672c\u54c1\u66fe\u4e8e\u4e0a\u4e16\u7eaa90\u5e74\u4ee3\u4f5c\u4e3a\u517d\u836f\u4f7f\u7528\uff0c\u7528\u4e8e\u72d7\u3001\u725b\u3001\u9a6c\u3001\u7ef5\u7f8a\u7b49\u52a8\u7269\u7684\u6297\u5bc4\u751f\u866b\u75c5\u7684\u6cbb\u7597\uff0c\u8fd9\u6b21\u6279\u51c6\u662f\u8fd9\u662f\u83ab\u897f\u83cc\u7d20\u5728\u4eba\u4f53\u4e0a\u7684\u9996\u6b21\u5e94\u7528<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[2]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u76d8\u5c3e\u4e1d\u866b\u75c5\u591a\u53d1\u751f\u5728\u6492\u54c8\u62c9\u4ee5\u5357\u7684\u975e\u6d32\u3001\u963f\u62c9\u4f2f\u534a\u5c9b\u4ee5\u53ca\u7f8e\u6d32\u7684\u90e8\u5206\u5730\u533a\u3002\u76ee\u524d\u6709\u4ec52\u4ebf\u4eba\u60a3\u6709\u8fd9\u79cd\u75be\u75c5\uff0c\u8d85\u8fc799\uff05\u7684\u611f\u67d3\u8005\u5728\u6492\u54c8\u62c9\u4ee5\u5357\u975e\u6d32\u7684\u7ea630\u4e2a\u56fd\u5bb6\u3002\u53ef\u80fd\u662f\u7531\u4e8e\u70ed\u5e26\u75c5\u7684\u53d1\u75c5\u4eba\u7fa4\u53ca\u5730\u57df\u7684\u5c40\u9650\u6027\uff0c\u76ee\u524d\u56fd\u5185\u5916\u5bf9\u76d8\u5c3e\u4e1d\u866b\u75c5\u7684\u5728\u7814\u836f\u7269\u6bd4\u8f83\u8d2b\u7620<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[2]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress6-1533787510.jpg\" alt=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u83ab\u897f\u83cc\u7d20\u5bf9\u76d8\u5c3e\u4e1d\u866b\uff08O.volvulus\uff09\u7684\u4f5c\u7528\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\uff0c\u53ef\u80fd\u4e0e\u5176\u5b83\u7c73\u8d1d\u9709\u7d20\u7c7b\u5927\u73af\u5185\u916f\u5316\u5408\u7269\u5982\u4f0a\u7ef4\u83cc\u7d20\u4e00\u6837\uff0c\u901a\u8fc7\u4e0e\u8c37\u6c28\u9178\u95e8\u63a7\u6c2f\u79bb\u5b50\u901a\u9053\uff08GluCl\uff09\u3001\u03b3-\u6c28\u57fa\u4e01\u9178\uff08GABA\uff09\u53d7\u4f53\u6216ATP\u7ed3\u5408\u76d2\u5f0f\u8f6c\u8fd0\u86cb\u767d\u7ed3\u5408\uff0c\u5bfc\u81f4\u6e17\u900f\u6027\u589e\u52a0\uff0c\u7ee7\u800c\u5f15\u8d77\u6c2f\u79bb\u5b50\u5185\u6d41\u589e\u52a0\uff0c\u5e26\u8d1f\u7535\u8377Cl-\u5f15\u8d77\u795e\u7ecf\u5143\u4f11\u6b62\u7535\u4f4d\u8d85\u6781\u5316\uff0c\u4f7f\u6b63\u5e38\u7684\u52a8\u4f5c\u7535\u4f4d\u4e0d\u80fd\u91ca\u653e\uff0c\u8fdb\u800c\u5f71\u54cd\u5bc4\u751f\u866b\u7684\u6240\u6709\u9636\u6bb5\u7684\u8fd0\u52a8\u6027\uff0c\u5bfc\u81f4\u866b\u4f53\u9ebb\u75f9\u6b7b\u4ea1\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u83ab\u897f\u83cc\u7d20\u7247\u6cbb\u7597\u76d8\u5c3e\u4e1d\u866b\u75c5\u7684\u4e34\u5e8a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u8bc4\u4f30\u57fa\u4e8e\u4e24\u9879\u5bf9O. volvulus\u60a3\u8005\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u9633\u6027\u5bf9\u7167\u8bd5\u9a8c\uff1a\u4e00\u9879\u662f\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08\u8bd5\u9a8c1\uff0cNCT00790998\uff09\uff0c\u53e6\u4e00\u9879\u662f\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08\u8bd5\u9a8c2\uff0cNCT 00300768\uff09\u3002\u901a\u8fc7\u5206\u6790\u76ae\u80a4\u4e2d\u5fae\u4e1d\u86b4\u7684\u5bc6\u5ea6\u53d1\u73b0\uff0c\u83ab\u897f\u83cc\u7d20\u6bd4\u4f0a\u7ef4\u83cc\u7d20\u5177\u6709\u663e\u8457\u4f18\u52bf\u3002\u4e0a\u8ff0\u4e24\u9879\u4e34\u5e8a\u8bd5\u9a8c\u9a8c\u4e2d\u6ca1\u6709\u4efb\u4f55\u4e00\u540d\u60a3\u8005\u56e0\u4e3a\u4e0d\u826f\u53cd\u5e94\u9000\u51fa\u8bd5\u9a8c\u3002\u83ab\u897f\u83cc\u7d20\u6cbb\u7597\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u4e0eMazotti\u53cd\u5e94\u76f8\u5173\u7684\u5168\u8eab\u3001\u773c\u79d1\u4e0d\u826f\u53cd\u5e94\u6216\u5b9e\u9a8c\u5ba4\u5f02\u5e38\uff0c\u8fd9\u4e9b\u4e0d\u826f\u53cd\u5e94\u662f\u7531\u4e8e\u8fc7\u654f\u6027\u6216\u708e\u75c7\u5bbf\u4e3b\u5bf9\u4e8e\u5fae\u4e1d\u86b4\u6b7b\u4ea1\u7684\u53cd\u5e94\uff0c\u60a3\u8005\u7684\u5fae\u4e1d\u86b4\u8d8a\u4e25\u91cd\uff0c\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7684\u53ef\u80fd\u6027\u8d8a\u5927<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[3]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u83ab\u897f\u83cc\u7d20\u662f\u7c73\u5c14\u8d1d\u9709\u7d20\u5927\u73af\u5185\u916f\u5316\u5408\u7269\u5bb6\u65cf\u7684\u7b2c\u4e8c\u4ee3\u6740\u83cc\u5242\uff0c\u800c\u4e14\u6bd4\u4e0a\u4e00\u4ee3\u6297\u5bc4\u751f\u866b\u836f\u7269\u4f0a\u7ef4\u83cc\u7d20\u6709\u6548\uff0c\u5b83\u867d\u4e0d\u80fd\u6709\u6548\u6740\u6b7b\u6210\u866b\uff0c\u4f46\u5b83\u4f1a\u6291\u5236O.volvulus\u6210\u866b\u7684\u5fae\u4e1d\u86b4\u91ca\u653e\u3002\u6210\u4e3a\u76d8\u5c3e\u4e1d\u866b\u75c5\u60a3\u8005\u7684\u53c8\u4e00\u9009\u62e9\uff0c\u8fd9\u4e5f\u662f\u4eba\u7c7b\u6297\u5bc4\u751f\u866b\u75be\u75c5\u6218\u4e89\u7684\u53c8\u4e00\u80dc\u5229\u3002\u83ab\u897f\u9709\u7d20\u7684\u5316\u5408\u7269\u4e13\u5229US4916154A\u5df2\u7ecf\u8fc7\u671f\uff0c\u800c\u4e14\u5176\u4e0a\u4e00\u4ee3\u836f\u7269\u4f9d\u7ef4\u83cc\u7d20\u5df2\u7ecf\u5728\u8bb8\u591a\u75be\u75c5\u9886\u57df\u5c55\u793a\u51fa\u975e\u51e1\u6f5c\u529b\uff0c\u56e0\u6b64\u6211\u4eec\u671f\u5f85\u7740\u83ab\u897f\u83cc\u7d20\u5728\u6297\u5bc4\u751f\u866b\u75c5\u9886\u57df\u7684\u5de8\u5927\u7a81\u7834\u3002\u8001\u836f\u65b0\u7528\uff0c\u4e5f\u8bb8\u662f\u8fd1\u4ee3\u5236\u836f\u884c\u4e1a\u7684\u4e00\u6761\u8e4a\u5f84\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[1]\u836f\u6e21\u6570\u636e\uff1a<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">https:\/\/data.pharmacodia.com\/web\/basic\/basic_detail_PN9712.html(accessed June 2018)<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[2]FDA Database.<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2018\/210867Orig1s000MicroR.pdf (accessedJune 2018)<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[3]FDA Database.<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/210867lbl.pdf (accessedJune 2018)<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"text-align:center;\">\n<section style=\"width: 2.5em;height: 3em;color: rgb(255, 255, 255);font-size: 1em;line-height: 3em;display: inline-block;background-image: url('http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533787515.gif');background-repeat: no-repeat;background-size: 100%;background-position: 0px center;\">\n<p class=\"autonum\"  title=\"\">2<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 16px;\"><strong><span style=\"color: rgb(0, 0, 0);\">Plazomicin sulf<\/span><\/strong><\/span><span style=\"font-size: 16px;\"><strong><span style=\"font-size: 16px;color: rgb(0, 0, 0);\">at<\/span><\/strong><\/span><span style=\"font-size: 16px;\"><strong><span style=\"color: rgb(0, 0, 0);\">e<\/span><\/strong><\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"width: 245px;height: 150px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress3-1533787510.png\" alt=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">Plazomicin\u662f\u4e00\u79cd\u65b0\u578b\u7684\u534a\u5408\u6210\u7684\u897f\u7d22\u7c73\u661f\uff08Sisomicin\uff09\u6c28\u57fa\u7cd6\u82f7\u7c7b\u884d\u751f\u7269\uff0c\u6700\u521d\u662f\u7531Ionis\u5236\u836f\u7814\u53d1\uff0c2006\u5e741\u6708\u6388\u6743\u7ed9Achaogen\uff0c\u8be5\u836f\u4e8e2018\u5e746\u670825\u65e5\u83b7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u4e0a\u5e02\uff0c\u7531Achaogen\u5728\u7f8e\u56fd\u4e0a\u5e02\u9500\u552e\uff0c\u5546\u54c1\u540d\u4e3aZemdri<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\uff0c\u83b7\u6279\u7528\u4e8e\u6cbb\u759718\u5c81\u53ca\u4ee5\u4e0a\u60a3\u6709\u5305\u62ec\u80be\u76c2\u80be\u708e\u5728\u5185\u7684\u590d\u6742\u6027\u5c3f\u8def\u611f\u67d3\uff08cUTI\uff09<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[4]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u4ece20\u4e16\u7eaa40\u5e74\u4ee3\u9752\u9709\u7d20\u5f00\u59cb\u5e94\u7528\u81f3\u4eca\uff0c\u4eba\u7c7b\u7684\u65b0\u836f\u7814\u53d1\u4ece\u672a\u505c\u6b62\u4e0e\u8010\u836f\u5fae\u751f\u7269\u7684\u89d2\u9010\u3002\u8fd1\u5e74\u6765\uff0c\u4e0d\u65ad\u51fa\u73b0\u5404\u7c7b\u201c\u8d85\u7ea7\u7ec6\u83cc\u201d\u7684\u75c5\u5386\uff0c\u4e25\u91cd\u5a01\u80c1\u4eba\u7c7b\u5065\u5eb7\u3002\u82f1\u56fd\u653f\u5e9c\u66fe\u62a5\u9053\uff0c\u5168\u7403\u5927\u7ea6\u67095000\u4e07\u4eba\u6b7b\u4e8e\u8010\u836f\u83cc\u611f\u67d3<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[5]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002\u7f8e\u56fd\u4ec51\u5e74\u5c31\u82b1\u8d39\u5927\u7ea6350\u4ebf\u7f8e\u5143\u7528\u4e8e\u8010\u836f\u83cc\u611f\u67d3\u7684\u6cbb\u7597<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[6]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002\u4e3a\u4e86\u5c06\u8010\u836f\u83cc\u963b\u6321\u5728\u5c01\u9501\u7ebf\u4e4b\u5916\uff0c\u4eba\u7c7b\u5bf9\u65b0\u6297\u83cc\u836f\u7269\u9700\u6c42\u66f4\u52a0\u8feb\u5207\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress4-1533787511.jpg\" alt=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">Plazomicin\u662f\u65b0\u4e00\u4ee3\u6c28\u57fa\u7cd6\u82f7\u7c7b\u6297\u751f\u7d20\uff0c\u901a\u8fc7\u4e0e\u7ec6\u83cc30S\u6838\u7cd6\u4f53\u4e9a\u57fa\u7ed3\u5408\u5e76\u5e72\u6270\u86cb\u767d\u8d28\u5408\u6210\u4e2d\u7684\u5173\u952e\u6b65\u9aa4\u800c\u53d1\u6325\u4f5c\u7528\uff0c\u6740\u83cc\u4f5c\u7528\u5448\u73b0\u6d53\u5ea6\u4f9d\u8d56\u6027\u3002\u56e0\u5176\u542b\u6709\u7ed3\u6784\u4fee\u9970\uff0c\u80fd\u907f\u514d\u6c28\u57fa\u7cd6\u82f7\u7c7b\u6297\u751f\u7d20\u949d\u5316\u9176\uff08AMEs\uff09\u5305\u62ec\u4e59\u9170\u8f6c\u79fb\u9176\uff08AAC\uff09\uff0c\u78f7\u9178\u8f6c\u79fb\u9176\uff08APH\uff09\u548c\u6838\u82f7\u9178\u8f6c\u79fb\u9176\uff08ANT\uff09\u7834\u574f\u800c\u5931\u53bb\u6d3b\u6027\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">Plazomicin\u7684\u83b7\u6279\u4e3b\u8981\u57fa\u4e8e\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u975e\u52a3\u6548\u6027\u8bd5\u9a8c\uff08NCT02486627\uff09\uff0c\u5176\u8fbe\u5230\u4e86FDA\u9884\u8bbe\u7684\u5bf9\u590d\u6742\u6027\u5c3f\u8def\u611f\u67d3\uff08cUTI\uff09\u60a3\u8005\u4e34\u5e8a\u7814\u7a76\uff08EPIC\uff09\u4e2d\u975e\u52a3\u6548\u4e8e\u7f8e\u7f57\u57f9\u5357\u7684\u8bd5\u9a8c\u76ee\u6807\uff0c\u5373\u4e0e\u7f8e\u7f57\u57f9\u5357\u7ec4\u76f8\u6bd4\uff0c\u63a5\u53d7Plazomicin\u6cbb\u7597\u7684\u60a3\u8005\u7b2c5\u5929\u590d\u5408\u6cbb\u6108\u738788.0% vs. 91.4%\uff0895% CI\uff1a-10.0, 3.1\uff09\u8868\u660e\u7edf\u8ba1\u5b66\u975e\u52a3\u52bf\uff1bTOC\uff08\u7597\u6548\u5224\u5b9a\u65f6\uff09\u590d\u5408\u6cbb\u6108\u738781.7% vs. 70.1%\uff0895% CI\uff1a2.7, 20.3\uff09\u8868\u660e\u7edf\u8ba1\u5b66\u4f18\u52bf\u3002\u5728\u5fae\u751f\u7269\u5b66\u4e0a\u610f\u56fe\u6cbb\u7597\u7fa4\u4f53\uff08mMITT\uff09\u4e2d\u57fa\u7ebf\u5c3f\u8def\u75c5\u539f\u4f53\u5728TOC\u65f6\u7684\u5fae\u751f\u7269\u6839\u9664\u7387\u8f83\u7f8e\u7f57\u57f9\u5357\u66f4\u9ad889.4% vs. 75.5%\uff0895% CI\uff1a6.2, 21.5\uff09\u3002\u5728\u83cc\u8840\u75c7\u60a3\u8005\u4e9a\u7ec4\u4e2d\uff0c TOC\u65f6Plazomicin\u8f83\u7f8e\u7f57\u57f9\u5357\u8868\u73b0\u51fa\u826f\u597d\u7684\u590d\u5408\u6cbb\u6108\u738772.0% vs. 56.5%\uff0895% CI: -13.7, 41.9)<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[7]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">Plazomicin\u4f5c\u4e3a\u65b0\u4e00\u4ee3\u6c28\u57fa\u7cd6\u82f7\u7c7b\u836f\u7269\uff0c\u53ef\u907f\u514d\u591a\u79cd\u6c28\u57fa\u7cd6\u82f7\u7c7b\u6297\u751f\u7d20\u949d\u5316\u9176\uff08AMEs\uff09\u5bf9\u5176\u4fee\u9970\u800c\u4fdd\u6301\u6d3b\u6027\u3002\u622a\u6b622018\u5e746\u6708\uff0c\u5176\u4ec5\u5728\u7f8e\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u4e3a\u590d\u6742\u6027\u5c3f\u8def\u611f\u67d3\u60a3\u8005\u63d0\u4f9b\u4e86\u65b0\u7684\u9009\u62e9\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[4] \u836f\u6e21\u6570\u636e<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">https:\/\/data.pharmacodia.com\/web\/basic\/basic_detail_PN0850.html(accessedJune 2018)<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[5]Davies SC; Fowler T; Watson J, et al. TheLancet, 2013, 381(9878), 1606-1609.<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[6]Solomon SL; Oliver KB, American FamilyPhysician, 2014, 89(12), 938-941.<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[7]FDA Database.<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/210303Orig1s000lbl.pdf (accessedJune 2018)<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\"><br  \/><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"text-align:center;\">\n<section style=\"width: 2.5em;height: 3em;color: rgb(255, 255, 255);font-size: 1em;line-height: 3em;display: inline-block;background-image: url('http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533787515.gif');background-repeat: no-repeat;background-size: 100%;background-position: 0px center;\">\n<p class=\"autonum\"  title=\"\">3<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p style=\"text-align: center;\"><strong style=\";\">\u5927\u9ebb\u4e8c\u915a\uff08Cannabidiol\uff09<\/strong><br  \/><\/p>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"width: 199px;height: 116px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533787512.png\" alt=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u5927\u9ebb\u4e8c\u915a\uff08Cannabidiol\uff0cCBD\uff09\u4e8e2018\u5e746\u670825\u65e5\u5728\u7f8e\u56fd\u6279\u51c6\u4e0a\u5e02\uff0c\u662f\u9996\u4e2a\u83b7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u4e0a\u5e02\u7684\u542b\u7eaf\u5316\u5927\u9ebb\u63d0\u53d6\u7269\u7684\u65b0\u836f\u3002\u5927\u9ebb\u4e8c\u915a\u7531GW\u5236\u836f\u4e0a\u5e02\u9500\u552e\uff0c\u5546\u54c1\u540d\u4e3aEpidiolex<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\uff0c\u88ab\u6279\u51c6\u7528\u4e8e\u4e24\u5c81\u53ca\u4ee5\u4e0a\u7684\u60a3\u8005\u7684Lennox-Gastaut\u7efc\u5408\u5f81\uff08Lennox-Gastaut Syndrome\uff0cLGS\uff09\u548cDravet\u7efc\u5408\u5f81\uff08Dravet syndrome\uff0cDS\uff09\u5f15\u8d77\u7684\u766b\u75eb\u53d1\u4f5c\u8f85\u52a9\u6cbb\u7597\u3002\u5927\u9ebb\u4e8c\u915a\u5728\u4eba\u4f53\u5185\u53d1\u6325\u6297\u60ca\u53a5\u4f5c\u7528\u7684\u786e\u5207\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\u3002\u4f46\u5927\u9ebb\u4e8c\u915a\u663e\u793a\u51fa\u5177\u6709\u9547\u75db\u3001\u6297\u60ca\u53a5\u3001\u808c\u8089\u677e\u5f1b\u3001\u6297\u7126\u8651\u3001\u795e\u7ecf\u4fdd\u62a4\u3001\u6297\u6c27\u5316\u548c\u6297\u7cbe\u795e\u75c5\u7684\u6d3b\u6027<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[8]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">Lennox-Gastaut\u7efc\u5408\u5f81\u548cDravet\u7efc\u5408\u5f81\u662f\u4e24\u7c7b\u7f55\u89c1\u7684\u766b\u75eb\u75be\u75c5\u3002Lennox-Gastaut\u7efc\u5408\u5f81\u662f\u4e00\u79cd\u4e0e\u5e74\u9f84\u6709\u5173\u7684\u9690\u6e90\u6027\u6216\u75c7\u72b6\u6027\u5168\u8eab\u6027\u766b\u75eb\u7efc\u5408\u5f81\uff0c\u53ef\u4ee5\u7531\u8bb8\u591a\u75c5\u75c7\u5f15\u8d77\uff0c\u5305\u62ec\u8111\u7578\u5f62\u3001\u4e25\u91cd\u7684\u5934\u90e8\u635f\u4f24\u3001\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u611f\u67d3\u548c\u9057\u4f20\u6027\u795e\u7ecf\u53d8\u6027\u6216\u4ee3\u8c22\u75c5\u75c7\u3002\u5927\u591a\u6570\u60a3\u6709LGS\u7684\u513f\u7ae5\u4f1a\u51fa\u73b0\u4e00\u5b9a\u7a0b\u5ea6\u7684\u667a\u529b\u969c\u788d\uff0c\u4ee5\u53ca\u53d1\u80b2\u8fdf\u7f13\u548c\u5f02\u5e38\u884c\u4e3a\u3002Dravet\u7efc\u5408\u5f81\u53c8\u79f0\u5a74\u513f\u4e25\u91cd\u808c\u9635\u631b\u6027\u766b\u75eb\uff08(severe myoclonic epilepsy in infarlcy\uff0cSMEI\uff09\u662f\u4e00\u79cd\u4e25\u91cd\u7684\u5a74\u513f\u53d1\u75c5\u548c\u9ad8\u5ea6\u6cbb\u7597\u62b5\u6297\u7684\u766b\u75eb\u6027\u8111\u75c5\uff0c\u5e38\u4e0eSCN1A\u94a0\u901a\u9053\u7684\u57fa\u56e0\u7a81\u53d8\u6709\u5173\u3002\u603b\u4f53\u53d1\u75c5\u7387\u7ea6\u4e3a1\/20000-40000\uff0c\u7537\uff1a\u5973\u7ea6\u4e3a2\uff1a1\uff0c\u7ea6\u5360\u5c0f\u513f\u5404\u578b\u808c\u9635\u631b\u6027\u766b\u75eb\u768429.5%\uff0c\u53603\u5c81\u4ee5\u5185\u5a74\u5e7c\u513f\u7ae5\u766b\u75eb\u76847%\u3002Dravet\u7efc\u5408\u5f81\u5177\u6709\u53d1\u75c5\u5e74\u9f84\u65e9\uff0c\u53d1\u4f5c\u7c7b\u578b\u591a\u6837\uff0c\u667a\u80fd\u635f\u5bb3\u4e25\u91cd\uff0c\u836f\u7269\u6cbb\u7597\u6548\u679c\u5dee\u7b49\u7279\u70b9\u3002\u6b64\u5916\uff0c\u5927\u591a\u6570\u4eba\u5c06\u53d1\u5c55\u4e2d\u5ea6\u81f3\u4e25\u91cd\u7684\u667a\u529b\u548c\u53d1\u80b2\u969c\u788d\uff0c\u5e76\u9700\u8981\u7ec8\u8eab\u76d1\u7763\u548c\u7167\u987e<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[9]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533787512.jpg\" alt=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u5927\u9ebb\u4e8c\u915a\u6cbb\u7597Lennox\u2013Gastaut\u7efc\u5408\u5f81\u7684\u4e34\u5e8a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u8bc4\u4f30\u57fa\u4e8e\u4e24\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5bf9\u7167\u8bd5\u9a8c\u3002\u572814\u5468\u6cbb\u7597\u671f\u95f4\uff0c\u5927\u9ebb\u4e8c\u915a\u7ec4\u6709\u66f4\u663e\u8457\u7684\u766b\u75eb\u53d1\u4f5c\u4e2d\u4f4d\u6570\u51cf\u5c11\uff0844% vs. 22%,p=0.0135\uff09\uff0c\u8fbe\u5230\u4e86\u8be5\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u3002\u53e6\u5916\uff0c\u60a3\u8005\u5bf9\u52a0\u5165\u5927\u9ebb\u4e8c\u915a\u6cbb\u7597\u7684\u8010\u53d7\u6027\u8f83\u597d\uff0c\u5b89\u5168\u6027\u4e5f\u4e0e\u62a5\u9053\u7684\u7ed3\u679c\u4e00\u81f4\uff0c\u591a\u6570\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u8f7b\u6216\u4e2d\u5ea6<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[10]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u5927\u9ebb\u4e8c\u915a\u6cbb\u7597Dravet\u7efc\u5408\u5f81\u7684\u4e34\u5e8a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7684\u8bc4\u4f30\u57fa\u4e8e\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\u3002\u60a3\u8005\u89c2\u5bdf4\u5468\u540e\u4f7f\u752814\u5468\u5927\u9ebb\u4e8c\u915a\u6216\u5b89\u6170\u5242\uff0c\u7ed3\u679c\u5927\u9ebb\u4e8c\u915a\u7ec4\u60a3\u8005\u53d1\u75c5\u6b21\u6570\u4ece\u6bcf\u670812.4\u6b21\u964d\u52305.9\u6b21\uff0c\u5b89\u6170\u5242\u7ec4\u4ece\u6bcf\u670814.9\u6b21\u964d\u523014.1\u6b21\u300243%\u7684\u5927\u9ebb\u4e8c\u915a\u7ec4\u60a3\u8005\u53d1\u75c5\u6b21\u6570\u51cf\u534a\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u53ea\u670917%\u60a3\u8005\u53d1\u75c5\u6b21\u6570\u51cf\u534a\u3002\u53e6\u67095%\u60a3\u8005\u4f7f\u7528\u5927\u9ebb\u4e8c\u915a\u540e\u766b\u75eb\u6d88\u5931\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u6ca1\u6709<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[10]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u5927\u9ebb\u4e8c\u915a\u662f\u9996\u6b3e\u83b7FDA\u6279\u51c6\u4e0a\u5e02\u7684\u542b\u7eaf\u5316\u5927\u9ebb\u63d0\u53d6\u7269\u7684\u65b0\u836f\uff0c\u7528\u4e8e\u8f85\u52a9\u6cbb\u7597\u4e24\u7c7b\u7f55\u89c1\u7684\u766b\u75eb\u75be\u75c5Lennox-Gastaut\u7efc\u5408\u5f81\u548cDravet\u7efc\u5408\u5f81\u3002\u8be5\u836f\u9664\u4e86\u7ed9 Lennox-Gastaut \u7efc\u5408\u5f81\u60a3\u8005\u5e26\u6765\u53c8\u4e00\u6b3e\u91cd\u8981\u6cbb\u7597\u65b9\u6848\u5916\uff0c\u7ed9 Dravet \u7efc\u5408\u5f81\u60a3\u8005\u5e26\u6765\u4e86\u9996\u6b3e\u83b7\u6279\u65b0\u836f\uff0c\u5c06\u5bf9\u4ed6\u4eec\u7684\u60c5\u51b5\u5e26\u6765\u91cd\u8981\u4e14\u6025\u9700\u7684\u6539\u5584<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[11]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[8]\u836f\u6e21\u6570\u636e:&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">https:\/\/data.pharmacodia.com\/web\/basic\/basic_detail_PN0763.html (accessedJune 2018)<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[9]GW Pharmaceuticals \u5b98\u65b9\u7f51\u7ad9: <\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">https:\/\/www.gwpharm.com\/about-us\/news\/gw-pharmaceuticals-and-its-us-subsidiary-greenwich-biosciences-completes-rolling-new (accessedJune 2018)<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[10]FDA Database.<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/210365lbl.pdf(accessedJune 2018)<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[11]FDA approves first drug comprised of an active ingredient derived frommarijuana to treat rare, severe forms of epilepsy:<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">https:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm611046.htm(accessedJune 2018)<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\"><br  \/><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"text-align:center;\">\n<section style=\"width: 2.5em;height: 3em;color: rgb(255, 255, 255);font-size: 1em;line-height: 3em;display: inline-block;background-image: url('http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533787515.gif');background-repeat: no-repeat;background-size: 100%;background-position: 0px center;\">\n<p class=\"autonum\"  title=\"\">4<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p style=\"text-align: center;\"><strong style=\";\">Encorafenib\u3001Binimetinib<\/strong><br  \/><\/p>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"width: 381px;height: 154px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress1-1533787512.png\" alt=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">2018\u5e746\u670827\u65e5\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u4e86Array BioPharma\u63d0\u4ea4\u7684\u8054\u5408\u5e94\u7528Encorafenib\u548cBinimetinib\u6cbb\u7597BRAF V600E\u6216V600K\u7a81\u53d8\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u7684\u4e0a\u5e02\u7533\u8bf7\u3002Encorafenib\u662f\u4e00\u79cd\u4e1d\u6c28\u9178\/\u82cf\u6c28\u9178\u86cb\u767d\u6fc0\u9176BRAF\u6291\u5236\u5242\uff0cBinimetinib\u662f\u4e00\u79cd\u4fc3\u5206\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\u6fc0\u9176MEK1\/2\u6291\u5236\u5242\uff0cBRAF\u548cMEK\u662f\u8c03\u63a7MAPK\u4fe1\u53f7\u901a\u8def\uff08RAS-RAF-MEK-ERK\uff09\u4e2d\u7684\u5173\u952e\u86cb\u767d\u6fc0\u9176\uff0c\u8fd9\u4e9b\u6fc0\u9176\u5747\u53ef\u4ee5\u901a\u8fc7\u4e0d\u540c\u7684\u5206\u5b50\u4fe1\u53f7\u6fc0\u6d3b\uff0c\u518d\u4f9d\u6b21\u901a\u8fc7\u78f7\u9178\u5316\u5c06\u4e0a\u6e38\u4fe1\u53f7\u4f20\u9012\u81f3\u4e0b\u6e38\u5e94\u7b54\u5206\u5b50\uff0c\u6700\u7ec8\u5c06\u7ec6\u80de\u5916\u7684\u523a\u6fc0\u4fe1\u53f7\u4f20\u5bfc\u81f3\u7ec6\u80de\u53ca\u6838\u5185\uff0c\u4ece\u800c\u5f15\u8d77\u7ec6\u80de\u53d1\u751f\u589e\u6b96\u3001\u5206\u5316\u3001\u8f6c\u5316\u53ca\u51cb\u4ea1\u7b49\u751f\u7269\u5b66\u53cd\u5e94<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[12]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u9ed1\u8272\u7d20\u7624\uff0c\u53c8\u79f0\u4e3a\u6076\u6027\u9ed1\u8272\u7d20\u7624\uff0c\u662f\u6765\u6e90\u4e8e\u9ed1\u8272\u7d20\u7ec6\u80de\u7684\u4e00\u7c7b\u6076\u6027\u80bf\u7624\u3002\u8fd1\u5e74\u6765\u5df2\u6210\u4e3a\u6240\u6709\u6076\u6027\u80bf\u7624\u4e2d\u53d1\u75c5\u7387\u589e\u957f\u6700\u5feb\u7684\u80bf\u7624\uff0c\u5e74\u589e\u957f\u7387\u4e3a3%-5%\u3002\u636eGlobaldata\u9ed1\u8272\u7d20\u7624\u75be\u75c5\u62a5\u544a\u7edf\u8ba1\uff0c2016\u5e74\u5168\u7403\u9ed1\u8272\u7d20\u7624\u5e02\u573a\u5bb9\u91cf\u4e3a83.80\u4ebf\u7f8e\u5143\uff0c\u9884\u4f302023\u5e74\u5e02\u573a\u5bb9\u91cf\u5c06\u8fbe\u5230412.64\u4ebf\u7f8e\u5143\uff0c\u5e74\u590d\u5408\u589e\u957f\u7387\u4e3a42.3%\u3002\u6211\u56fd\u9ed1\u8272\u7d20\u7624\u7684\u53d1\u75c5\u7387\u8f83\u4f4e\uff0c\u4f46\u8fd1\u5e74\u6765\u5448\u73b0\u5feb\u901f\u589e\u957f\u8d8b\u52bf\uff0c\u6bcf\u5e74\u65b0\u53d1\u75c5\u4f8b\u7ea62\u4e07\u4eba\uff0c\u6b7b\u4ea1\u7387\u4e5f\u5448\u9010\u5e74\u5feb\u901f\u4e0a\u5347\u7684\u8d8b\u52bf\u3002\u8fd1\u5e74\u6765\uff0c\u665a\u671f\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7597\u53d6\u5f97\u4e86\u7a81\u7834\u6027\u8fdb\u5c55\uff0c\u9664\u4f20\u7edf\u5316\u7597\u65b9\u6cd5\uff0c\u514d\u75ab\u7597\u6cd5\u548c\u9776\u5411\u6cbb\u7597\u662f\u76ee\u524d\u7684\u6cbb\u7597\u70ed\u70b9\u65b9\u5411\u3002\u88681\u5217\u51fa\u4e86\u76ee\u524d\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u7684\u5df2\u7ecf\u4e0a\u5e02\u7684\u514d\u75ab\u7597\u6cd5\u548c\u9776\u5411\u7597\u6cd5\u7684\u836f\u7269\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress6-1533787513.jpg\" alt=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u6b64\u6b21Encorafenib\u8054\u5408Binimetinib\u9776\u5411\u7ec4\u5408\u7597\u6cd5\u7684\u83b7\u6279\u662f\u57fa\u4e8e\u4e00\u9879\u5173\u952e\u7684\u4e34\u5e8a\u4e09\u671f\u8bd5\u9a8c\u6570\u636e\uff08COLUMBUS; NCT01909453\uff09\uff0c\u65e8\u5728\u8bc4\u4f30Encorafenib+Binimetinib\u8054\u5408\u7528\u836f\u6cbb\u7597BRAF V600E\u6216V600K\u7a81\u53d8\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u4e0e\u5355\u4e00\u7528\u836f\u7ef4\u7f57\u975e\u5c3c\u6216Encorafenib\u7684\u7597\u6548\u6027\u4e0e\u5b89\u5168\u6027\u3002\u7ed3\u679c\u663e\u793a\uff0cEncorafenib+Binimetinib\u7ec4\u5408\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5728\u7edf\u8ba1\u5b66\u4e0a\u6709\u663e\u8457\u6539\u5584\u3002Encorafenib+Binimetinib\u7ec4\u3001Encorafenib\u5355\u836f\u7ec4\u548c\u7ef4\u7f57\u975e\u5c3c\u5355\u836f\u7ec4\u7684PFS\u5bf9\u6bd4\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u5206\u522b\u4e3a14.9\u4e2a\u6708\u30019.6\u4e2a\u6708\u548c7.3\u4e2a\u6708<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[13]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u5728\u7f8e\u56fdNCCN\u9ed1\u8272\u7d20\u7624\u8bca\u7597\u6307\u5357\u4e2d\uff0c\u9488\u5bf9BRAF V600\u7a81\u53d8\u7684\u4e00\u7ebf\u9776\u5411\u836f\u7269\uff0c\u5728\u4e34\u5e8a\u4f7f\u7528\u4e2d\u4ee5\u8054\u5408\u7528\u836f\u4e3a\u4e3b\uff0c\u5305\u62ecTrametinib\uff08\u8fbe\u62c9\u975e\u5c3c\uff09\u548cTrametinib\uff08\u66f2\u7f8e\u66ff\u5c3c\uff09\u8054\u7528\uff0cVemurafenib\uff08\u7ef4\u7f57\u975e\u5c3c\uff09\u548cCobimetinib\uff08\u53ef\u7f8e\u66ff\u5c3c\uff09\u8054\u7528\u3002\u6b64\u6b21Encorafenib+Binimetinib\u7ec4\u5408\u6cbb\u7597\u7684\u83b7\u6279\uff0c\u4e3aBRAF\u7a81\u53d8\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u63d0\u4f9b\u4e86\u4e00\u4e2a\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u8be5\u7ec4\u5408\u7597\u6cd5\u76ee\u524d\u4e5f\u6b63\u5728\u5f00\u5c55\u4e0e\u897f\u59a5\u6614\u5355\u6297\uff08Cetuximab\uff09\u8054\u7528\u6cbb\u7597\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u4e34\u5e8a\u4e09\u671f\u7814\u7a76\uff0c\u6b64\u4e34\u5e8a\u8bd5\u9a8c\u5c1a\u672a\u5b8c\u6210\uff0c\u4f46\u662fArrayBioPharma\u5b98\u7f51\u5df2\u4e8e2017\u5e749\u6708\u62ab\u9732\u4e86\u90e8\u5206\u7ed3\u679c\uff0c\u5176\u8054\u5408\u7528\u836f\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a41\uff05\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[12]\u836f\u6e21\u6570\u636e:&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">https:\/\/data.pharmacodia.com\/web\/basic\/basic_detail_PN0662.html<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">https:\/\/data.pharmacodia.com\/web\/basic\/basic_detail_PN0663.html (accessedJune 2018)<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[13]Reinhard D; Paolo A A; Helen J G, et al. LancetOncology. 2018, 19(5), 603-615<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\"><br  \/><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;font-family:\u5fae\u8f6f\u96c5\u9ed1;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"text-align:center;\">\n<section style=\"width: 2.5em;height: 3em;color: rgb(255, 255, 255);font-size: 1em;line-height: 3em;display: inline-block;background-image: url('http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533787515.gif');background-repeat: no-repeat;background-size: 100%;background-position: 0px center;\">\n<p class=\"autonum\"  title=\"\">5<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 16px;\"><strong><span style=\"font-size: 16px;color: rgb(0, 0, 0);\">\u8fbe\u8bfa\u745e\u97e6\u94a0\uff08Danoprevir sodium\uff09<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"width: 184px;height: 185px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress3-1533787513.png\" alt=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u8fbe\u8bfa\u745e\u97e6\u94a0\uff08Danoprevirsodium\uff0c\u53c8\u540d\u4e39\u8bfa\u745e\u97e6\u94a0\uff09\u4e8e2018\u5e746\u67088\u65e5\u83b7\u4e2d\u56fd\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u4e0a\u5e02\uff0c\u7531\u6b4c\u793c\u836f\u4e1a\u4e0a\u5e02\u9500\u552e\uff0c\u5546\u54c1\u540d\u4e3a\u6208\u8bfa\u536b<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002\u8fbe\u8bfa\u745e\u97e6\u94a0\u662fHCV NS3\/4A\u86cb\u767d\u9176\u6291\u5236\u5242\uff0c\u6208\u8bfa\u536b<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u83b7\u6279\u4e0e\u805a\u4e59\u4e8c\u9187\u5e72\u6270\u7d20\u548c\u5229\u5df4\u97e6\u6797\u8054\u7528\u6cbb\u7597\u4e19\u809d\u3002\u8be5\u5316\u5408\u7269\u6700\u521d\u7531InterMune\u548cArray BioPharma\u8054\u5408\u5f00\u53d1\uff0c2006\u5e74\u88ab\u6388\u6743\u7ed9\u7f57\u6c0f\u30022010\u5e74InterMune\u5c06\u8fbe\u8bfa\u745e\u97e6\u94a0\u7684\u5168\u7403\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u5229\u51fa\u552e\u7ed9\u7f57\u6c0f\uff0c2013\u5e74\u7f57\u6c0f\u5c06\u4e2d\u56fd\u7684\u7814\u53d1\u6743\u6388\u6743\u7ed9\u6b4c\u793c\uff0c2014\u5e74InterMune\u88ab\u7f57\u6c0f\u6536\u8d2d<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[14]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533787513.jpg\" alt=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">Array BioPharma\u548cInterMune\u5728WO2005037214\u4e2d\u9996\u6b21\u62ab\u9732\u8fbe\u8bfa\u745e\u97e6\u94a0\uff0c\u867d\u7136\u6ca1\u6709\u7279\u522b\u8981\u6c42\u4fdd\u62a4\u7684\u5316\u5408\u7269\uff0c\u4f46\u8fbe\u8bfa\u745e\u97e6\u94a0\u88ab\u9a6c\u5e93\u4ec0\u7ed3\u6784\u6240\u8986\u76d6\uff0c\u4f8b\u5982\u5316\u5408\u7269AR00334191\uff08\u7b2c178\u9875\uff09\u3002 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0);\">\u4e19\u578b\u809d\u708e\u662f\u4e00\u4e2a\u516c\u5171\u536b\u751f\u95ee\u9898\uff0c\u636e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u4f30\u8ba1\uff0c\u67091.15\u4ebf\u4eba\u6162\u6027\u611f\u67d3HCV\uff0c\u6bcf\u5e74\u6709300\u4e07\u81f3400\u4e07\u65b0\u611f\u67d3\u8005\uff0c\u662f\u4e00\u4e2a\u975e\u5e38\u5927\u7684\u5e02\u573a\uff0c\u5927\u7ea675\uff05\u7684\u75c5\u4f8b\u672a\u80fd\u53ca\u65f6\u8bca\u65ad\u53ca\u6cbb\u7597\u800c\u6f14\u53d8\u6210\u6162\u6027\u75c5\u72b6<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">[15]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u3002HCV\u75ab\u82d7\u7684\u5f00\u53d1\u53d7\u5230\u82e5\u5e72\u6311\u6218\u7684\u963b\u788d\uff0c\u5305\u62ec\u75c5\u6bd2\u7684\u53d8\u5f02\u6027\u548c\u4e0d\u5b8c\u5168\u7684\u5929\u7136\u514d\u75ab\uff0c\u5c3d\u7ba1\u8fdb\u884c\u4e86\u6570\u5341\u5e74\u7684\u7814\u7a76\uff0c\u75ab\u82d7\u7684\u5f00\u53d1\u5c1a\u672a\u6210\u529f\u3002\u8fbe\u8bfa\u745e\u97e6\u94a0\u4f5c\u4e3a\u65e0\u5e72\u6270\u7d20\u6cbb\u7597\u5e76\u7531\u4e2d\u56fd\u516c\u53f8\u5728\u4e2d\u56fd\u63a8\u5411\u5e02\u573a\uff0c\u6b4c\u793c\u5728\u4e2d\u56fd\u8425\u9500\u4ea7\u54c1\u65b9\u9762\u4e0e\u5176\u4ed6\u516c\u53f8\u76f8\u6bd4\u5177\u6709\u4f18\u52bf\u3002\u4f46\u662f\uff0c\u8be5\u836f\u76ee\u524d\u4ec5\u5728\u4e2d\u56fd\u83b7\u5f97\u6279\u51c6\uff0c\u7f57\u6c0f\u4e8e2017\u5e744\u6708\u505c\u6b62\u5728\u8fdc\u4e1c\u4ee5\u5916\u7684\u5f00\u53d1\u3002\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u7684Daklinza<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u548cSunvepra<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u7684\u7ec4\u5408\u7528\u836f\u662f\u7b2c\u4e00\u4e2a\u5728\u4e2d\u56fd\u83b7\u5f97\u6279\u51c6\u7684\u5168\u53e3\u670d\u65e0\u5e72\u6270\u7d20\u6cbb\u7597\u65b9\u6848\uff0c\u5176\u4ed6\u4ea7\u54c1\u5305\u62ec\u4e2d\u56fd\u7684HCV\u5feb\u901f\u901a\u9053\uff0c\u5305\u62ec\u5409\u5229\u5fb7\u7684Harvoni<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u548c\u827e\u4f2f\u7ef4\u7684Viekira Pak<\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><sup><span style=\"color: rgb(0, 0, 0);font-size: 12px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u00ae<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">; \u5409\u5229\u5fb7\u9884\u8ba1\u5c06\u57282018\u52302019\u5e74\u5f00\u59cb\u5728\u4e2d\u56fd\u63a8\u51fa\u5176\u4ea7\u54c1\u3002\u8fbe\u8bfa\u745e\u97e6\u94a0\u7684\u9500\u552e\u672a\u6765\u4f1a\u9762\u4e34\u8bf8\u591a\u6311\u6218\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[14]\u836f\u6e21\u6570\u636e:&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">https:\/\/data.pharmacodia.com\/web\/basic\/basic_detail_PN0976.html (accessedJune 2018)<\/span><\/p>\n<p style=\"text-align: justify;line-height: normal;\"><span style=\"font-size: 10px;color: rgb(136, 136, 136);\">[15]World health organization: http:\/\/www.who.int\/hepatitis\/publications\/hepatitis-c-guidelines-2016\/en\/ (accessed June 2018)<\/span><\/p>\n<p><br  \/><\/p>\n<p><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533787513.jpg\" alt=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/p>\n<\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"padding: 10px;box-sizing: border-box;\">\n<section style=\"width:100%;\" >\n<section style=\"float:left;width:50px;height:38px;transform: rotate(90deg);-webkit-transform: rotate(90deg);-moz-transform: rotate(90deg);-ms-transform: rotate(90deg);-o-transform: rotate(90deg);\"><img class=\"\"     style=\"width:50px;vertical-align:middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress2-1533787514.gif\" alt=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\" title=\"2018\u5e746\u6708\u5168\u7403\u6279\u51c6\u65b0\u836f\u6982\u51b5\"  \/><\/section>\n<section style=\"float: left;\">\u7acb\u5373\u4f53\u9a8c\u836f\u6e21\u6570\u636e!<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u836f\u6e21                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>2018\u5e746\u6708\uff0cFDA\u5171\u6279\u51c64\u4e2a\u65b0\u5206\u5b50\u5b9e\u4f53\uff08NME\uff09\u836f\u7269\uff0c\u5206\u522b\u662f\u6cbb\u7597\u76d8\u5c3e\u4e1d\u866b\u75c5\u7684\u83ab\u897f\u83cc\u7d20\uff08Moxidectin [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":30014,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30013"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=30013"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30013\/revisions"}],"predecessor-version":[{"id":30034,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30013\/revisions\/30034"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/30014"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=30013"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=30013"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=30013"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}