{"id":30086,"date":"2018-08-06T01:00:00","date_gmt":"2018-08-09T04:05:41","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e3%80%90%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%85%e3%80%91%e6%af%94%e8%be%83hl04%ef%bc%88wbp264%ef%bc%89%e4%b8%8e%e5%ae%89%e7%bb%b4%e6%b1%80%e8%81%94%e5%90%88%e7%b4%ab%e6%9d%89%e9%86%87%e5%8d%a1%e9%93%82\/"},"modified":"2018-08-09T12:05:43","modified_gmt":"2018-08-09T04:05:43","slug":"%e3%80%90%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%85%e3%80%91%e6%af%94%e8%be%83hl04%ef%bc%88wbp264%ef%bc%89%e4%b8%8e%e5%ae%89%e7%bb%b4%e6%b1%80%e8%81%94%e5%90%88%e7%b4%ab%e6%9d%89%e9%86%87%e5%8d%a1%e9%93%82","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/30086\/","title":{"rendered":"\u3010\u62db\u52df\u60a3\u8005\u3011\u6bd4\u8f83HL04\uff08WBP264\uff09\u4e0e\u5b89\u7ef4\u6c40\u8054\u5408\u7d2b\u6749\u9187+\u5361\u94c2\u6cbb\u7597\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684III\u671f\u4e34\u5e8a\u7814\u7a76"},"content":{"rendered":"
\n
<\/mpcps><\/section>\n

<\/span><\/span>
<\/p>\n

1.       <\/span><\/span>\u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb<\/span><\/span><\/p>\n

HL04\/WBP264<\/span>\u662f\u8d1d\u4f10\u73e0\u5355\u6297\u7684\u751f\u7269\u7c7b\u4f3c\u836f\u3002<\/span><\/span><\/p>\n

\u672c\u8bd5\u9a8c\u7684\u9002\u5e94\u75c7\u662f\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/span><\/p>\n

 <\/span><\/p>\n

2.       <\/span><\/span>\u8bd5\u9a8c\u76ee\u7684<\/span><\/span><\/p>\n

\u4e3b\u8981\u76ee\u7684\u662f\u8bc4\u4ef7<\/span>HL04\/WBP264<\/span>\u548c\u5b89\u7ef4\u6c40<\/span>\u00ae<\/span>\u5728\u665a\u671f\u6216\u590d\u53d1\u6027\u975e\u9cde\u72b6\u7ec6\u80de\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684\u7597\u6548\u76f8\u4f3c\u6027\uff0c<\/span><\/span><\/p>\n

\u6b21\u8981\u76ee\u7684\u662f\u8bc4\u4ef7<\/span>HL04\/WBP264<\/span>\u548c\u5b89\u7ef4\u6c40<\/span>\u00ae<\/span>\u5728\u665a\u671f\u6216\u590d\u53d1\u6027\u975e\u9cde\u72b6\u7ec6\u80de\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\u53ca\u514d\u75ab\u539f\u6027\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

3.       <\/span><\/span>\u8bd5\u9a8c\u8bbe\u8ba1<\/span><\/span><\/p>\n

 \u8bd5\u9a8c\u5206\u7c7b\uff1a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/span><\/p>\n

  <\/span>\u8bd5\u9a8c\u5206\u671f\uff1a<\/span> III<\/span>\u671f<\/span><\/span><\/p>\n

  <\/span>\u8bbe\u8ba1\u7c7b\u578b\uff1a\u5e73\u884c\u5206\u7ec4<\/span> <\/span><\/span><\/p>\n

 \u968f\u673a\u5316\uff1a<\/span>     <\/span>\u968f\u673a\u5316<\/span><\/span><\/p>\n

  <\/span>\u76f2\u6cd5\uff1a<\/span>        <\/span>\u53cc\u76f2<\/span><\/span><\/p>\n

  <\/span>\u8bd5\u9a8c\u8303\u56f4\uff1a \u56fd\u5185<\/span> <\/span><\/span><\/p>\n

  <\/span>\u8bd5\u9a8c\u4eba\u6570\uff1a<\/span> 426<\/span><\/span><\/span><\/p>\n

 <\/span><\/p>\n

4.       <\/span><\/span>\u5165\u9009\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u53d7\u8bd5\u8005\u81ea\u613f\u53c2\u52a0\u672c\u8bd5\u9a8c\u5e76\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\uff1b<\/span><\/span><\/p>\n

2  <\/span>\u5e74\u9f84\u2265<\/span>18<\/span>\u5c81\u4e14\u2264<\/span>70<\/span>\u5c81\uff08\u4ee5\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\u65e5\u671f\u4e3a\u51c6\uff09\uff0c\u6027\u522b\u4e0d\u9650\uff1b<\/span><\/span><\/p>\n

3  <\/span>\u7ecf\u7ec4\u7ec7\u5b66\u6216\u7ec6\u80de\u5b66\u8bc1\u5b9e\u7684\u4e0d\u80fd\u624b\u672f\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\uff08<\/span>IIIb<\/span>\u671f\uff09\u3001\u8f6c\u79fb\u6027\uff08<\/span>IV<\/span>\u671f\uff09\u6216\u590d\u53d1\u6027\u7684\u975e\u9cde\u72b6\u7ec6\u80de\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08\u82e5\u6df7\u6709\u591a\u79cd\u80bf\u7624\u6210\u4efd\uff0c\u5219\u5e94\u6309\u5176\u4e3b\u8981\u7ec6\u80de\u7c7b\u578b\u8fdb\u884c\u5206\u7c7b\uff09\uff08\u6839\u636e<\/span>IASLC<\/span>\u7b2c<\/span>8<\/span>\u7248\u5206\u671f\u6807\u51c6\uff09\uff1b<\/span><\/span><\/p>\n

4  <\/span>\u5fc5\u987b\u81f3\u5c11\u6709\u4e00\u4e2a\u53ef\u6d4b\u91cf\u75c5\u7076\u4f5c\u4e3a\u9776\u75c5\u7076\uff08\u6839\u636e<\/span>RECIST V1.1<\/span>\u6807\u51c6\uff0c<\/span>CT<\/span>\u6216<\/span>MRI<\/span>\uff09\uff0c\u4e14\u8be5\u75c5\u7076\u672a\u63a5\u53d7\u8fc7\u653e\u5c04\u6cbb\u7597\uff1b<\/span><\/span><\/p>\n

5  <\/span>\u4e1c\u90e8\u80bf\u7624\u534f\u4f5c\u7ec4\u4f53\u529b\u72b6\u51b5\u8bc4\u5206\uff08<\/span>ECOG PS<\/span>\uff09\u4e3a<\/span>0-1<\/span>\u5206\uff1b<\/span><\/span><\/p>\n

6  <\/span>\u9884\u8ba1\u751f\u5b58\u65f6\u95f4\u2265<\/span>6<\/span>\u4e2a\u6708\uff1b<\/span><\/span><\/p>\n

7  <\/span>\u7b5b\u9009\u65f6\u7684\u5b9e\u9a8c\u5ba4\u7ed3\u679c\uff1a\u8840\u5e38\u89c4\uff1a\u767d\u7ec6\u80de\u8ba1\u6570\u2265<\/span>3.0<\/span>\u00d7<\/span>109\/L<\/span>\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u7edd\u5bf9\u503c\u2265<\/span>1.5<\/span>\u00d7<\/span>109\/L<\/span>\uff0c\u8840\u5c0f\u677f\u8ba1\u6570\u2265<\/span>100<\/span>\u00d7<\/span>109\/L<\/span>\uff0c\u8840\u7ea2\u86cb\u767d\u2265<\/span>90g\/L<\/span>\uff1b\u809d\u529f\u80fd\uff1a\u603b\u80c6\u7ea2\u7d20\u2264<\/span>1.5<\/span>\u00d7\u6b63\u5e38\u503c\u4e0a\u9650\uff08<\/span>ULN<\/span>\uff09\uff1b\u4e0d\u5b58\u5728\u809d\u8f6c\u79fb\u53d7\u8bd5\u8005\u5176\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08<\/span>ALT<\/span>\uff09\u548c\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08<\/span>AST<\/span>\uff09<\/span><2.5<\/span>\u00d7<\/span>ULN<\/span>\uff0c\u809d\u8f6c\u79fb\u53d7\u8bd5\u8005\u5176<\/span>ALT<\/span>\u548c<\/span>AST<5<\/span>\u00d7<\/span>ULN <\/span>\uff1b\u80be\u529f\u80fd\uff1a\u8840\u6e05\u808c\u9150\u2264<\/span>1.5<\/span>\u00d7<\/span>ULN<\/span>\u6216\u808c\u9150\u6e05\u9664\u7387\u2265<\/span>50ml\/min<\/span>\uff0c\u4e14\u5c3f\u5e38\u89c4\u68c0\u6d4b\u7ed3\u679c\u663e\u793a\u5c3f\u86cb\u767d<\/span><2+<\/span>\u3002\u5bf9\u57fa\u7ebf\u65f6\u5c3f\u5e38\u89c4\u68c0\u6d4b\u663e\u793a\u5c3f\u86cb\u767d\u2265<\/span>2+<\/span>\u7684\u53d7\u8bd5\u8005\uff0c\u5e94\u8fdb\u884c<\/span>24<\/span>\u5c0f\u65f6\u5c3f\u6db2\u91c7\u96c6\u4e14<\/span>24<\/span>\u5c0f\u65f6\u5185\u5c3f\u6db2\u4e2d\u7684\u86cb\u767d\u542b\u91cf<\/span><1.0g<\/span>\uff1b\u7814\u7a76\u6cbb\u7597\u524d<\/span>7<\/span>\u5929\u5185\uff0c\u56fd\u9645\u6807\u51c6\u5316\u6bd4\u7387\uff08<\/span>INR<\/span>\uff09\u2264<\/span>1.5<\/span>\uff0c\u4e14\u90e8\u5206\u4fc3\u51dd\u8840\u6d3b\u9176\u65f6\u95f4\uff08<\/span>PTT<\/span>\u6216<\/span>APTT<\/span>\uff09\u2264<\/span>1.5<\/span>\u00d7<\/span>ULN<\/span>\u3002<\/span><\/span><\/p>\n

8  <\/span>\u80b2\u9f84\u5973\u6027\u53d7\u8bd5\u8005\u3001\u7537\u6027\u53d7\u8bd5\u8005\u53ca\u7537\u6027\u53d7\u8bd5\u8005\u7684\u4f34\u4fa3\u540c\u610f\u5728\u672b\u6b21\u7814\u7a76\u836f\u7269\u8f93\u6ce8\u7ed3\u675f\u540e<\/span>6<\/span>\u4e2a\u6708\u5185\u4f7f\u7528\u53ef\u9760\u7684\u907f\u5b55\u63aa\u65bd\uff08\u5982\u7981\u6b32\u3001\u7edd\u80b2\u624b\u672f\u3001\u907f\u5b55\u836f\u3001\u6ce8\u5c04\u907f\u5b55\u836f\u7532\u5b55\u916e\u6216\u76ae\u4e0b\u57cb\u7f6e\u907f\u5b55\u7b49\uff09\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

5.       <\/span><\/span>\u6392\u9664\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u65e2\u5f80\u63a5\u53d7\u8fc7\u9488\u5bf9\u665a\u671f\u6216\u590d\u53d1\u6027\u975e\u9cde\u72b6\u7ec6\u80de\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u5168\u8eab\u5316\u7597\u3001\u6297\u8840\u7ba1\u751f\u6210\u836f\u7269\u6216\u5206\u5b50\u9776\u5411\u836f\u7269\u5168\u8eab\u6cbb\u7597\u7684\u60a3\u8005\uff08\u5bf9\u4e8e\u65e2\u5f80\u63a5\u53d7\u4e86\u6839\u6cbb\u672f\u540e\u8f85\u52a9\u5316\u7597\u548c<\/span>\/<\/span>\u6216\u672f\u524d\u65b0\u8f85\u52a9\u5316\u7597\u7684\u590d\u53d1\u6027\u80ba\u764c\u60a3\u8005\uff0c\u82e5\u5176\u5316\u7597\u540e<\/span>6<\/span>\u4e2a\u6708\u5185\u672a\u8fdb\u5c55\u6216\u672a\u590d\u53d1\uff0c\u4e14\u7b5b\u9009\u65f6\u6cbb\u7597\u76f8\u5173\u6bd2\u6027\u53cd\u5e94\u5df2\u6062\u590d\u3010<\/span>CTCAE4.03<\/span>\u6807\u51c6\u5224\u65ad\u2264<\/span>1<\/span>\u7ea7\uff0c\u79c3\u5934\u75c7\u9664\u5916\u3011\uff0c\u5219\u53ef\u4ee5\u5165\u7ec4\uff09\uff1b<\/span><\/span><\/p>\n

2  <\/span>\u6df7\u5408\u578b\u975e\u5c0f\u7ec6\u80de\u548c\u5c0f\u7ec6\u80de\u764c\u3001\u6216\u8005\u4ee5\u9cde\u72b6\u7ec6\u80de\u4e3a\u4e3b\u8981\u6210\u4efd\u7684\u6df7\u5408\u578b\u817a\u9cde\u764c\uff08\u817a\u764c\u4e3a\u4e3b\u8981\u7ec6\u80de\u6210\u5206\u7684\u6df7\u5408\u6027<\/span>NSCLC<\/span>\u53ef\u4ee5\u5165\u7ec4\uff09\uff1b<\/span><\/span><\/p>\n

3  EGFR<\/span>\u57fa\u56e0\u654f\u611f\u7a81\u53d8\u578b\uff08<\/span>EGFR<\/span>\u654f\u611f\u7a81\u53d8\u5305\u62ec<\/span>18<\/span>\u5916\u663e\u5b50\u70b9\u7a81\u53d8\uff08<\/span>G719X<\/span>\uff09\u3001<\/span>19<\/span>\u5916\u663e\u5b50\u7f3a\u5931\u548c<\/span>21<\/span>\u5916\u663e\u5b50\u70b9\u7a81\u53d8\uff08<\/span>L858R<\/span>\u548c<\/span>L861Q<\/span>\uff09\uff09\u3001<\/span>ALK<\/span>\u7a81\u53d8\u9633\u6027\u6216<\/span>ROS-1<\/span>\u7a81\u53d8\u9633\u6027\uff08\u7b5b\u9009\u65f6\u57fa\u56e0\u7a81\u53d8\u672a\u77e5\u7684\u60a3\u8005\u53ef\u4ee5\u5165\u7ec4\uff09\uff1b<\/span> <\/span><\/span><\/p>\n

4  CT\/MRI<\/span>\u5f71\u50cf\u663e\u793a\u80bf\u7624\u5305\u7ed5\u6216\u4fb5\u72af\u5927\u8840\u7ba1\u5185\u8154\uff08\u4f8b\u5982\u80ba\u52a8\u8109\u6216\u4e0a\u8154\u9759\u8109\uff09\uff1b<\/span><\/span><\/p>\n

5  <\/span>\u6709\u810a\u9ad3\u538b\u8feb\u6216\u764c\u6027\u8111\u819c\u708e\u53f2\uff0c\u6216\u7b5b\u9009\u65f6\u7ecf<\/span>CT<\/span>\u6216<\/span>MRI<\/span>\u8bc1\u5b9e\u8111\u90e8\u8f6c\u79fb\uff08\u82e5\u7b5b\u9009\u65f6\u5b58\u5728\u8111\u8f6c\u79fb\u7684\u60a3\u8005\u7ecf\u7814\u7a76\u8005\u5145\u5206\u8bc4\u4f30\uff0c\u7a33\u5b9a\u4e14\u6ca1\u6709\u51fa\u8840\u503e\u5411\uff0c\u5219\u53ef\u4ee5\u5165\u7ec4\uff09\uff1b<\/span><\/span><\/p>\n

6  <\/span>\u5728\u7b5b\u9009\u524d<\/span>28<\/span>\u5929\u5185\u63a5\u53d7\u80f8\u90e8\u6839\u6cbb\u6027\u653e\u7597\uff1b\u5728\u63a5\u53d7\u9996\u5242\u7814\u7a76\u836f\u7269\u6cbb\u7597\u524d<\/span>2<\/span>\u5468\u5185\u5bf9\u80f8\u90e8\u4e4b\u5916\u7684\u9aa8\u75c5\u7076\u8fdb\u884c\u59d1\u606f\u653e\u7597\u7684\u53d7\u8bd5\u8005\uff1b<\/span><\/span><\/p>\n

7  <\/span>\u5b58\u5728\u4e25\u91cd\u7684\u672a\u6108\u5408\u7684\u4f24\u53e3\u6e83\u75a1\u6216\u9aa8\u6298\uff0c\u6216\u968f\u673a\u524d<\/span>28<\/span>\u5929\u5185\u63a5\u53d7\u4e86\u91cd\u5927\u624b\u672f\uff0c\u6216\u9884\u671f\u5c06\u5728\u7814\u7a76\u671f\u95f4\u884c\u91cd\u5927\u624b\u672f\u8005\uff1b<\/span><\/span><\/p>\n

8  <\/span>\u5728\u9996\u6b21\u63a5\u53d7\u7814\u7a76\u836f\u7269\u524d<\/span>48<\/span>\u5c0f\u65f6\u5185\u8fdb\u884c\u8fc7\u5c0f\u624b\u672f\uff08\u5305\u62ec\u7f6e\u7ba1\uff09\uff08\u7531\u7814\u7a76\u8005\u5224\u65ad\u662f\u5426\u6709\u51fa\u8840\u503e\u5411\uff09\uff1b<\/span><\/span><\/p>\n

9  <\/span>\u5f53\u524d\u6216\u8fd1\u671f\uff08\u63a5\u53d7\u9996\u5242\u7814\u7a76\u836f\u7269\u524d<\/span>10<\/span>\u5929\u5185\uff09\u4f7f\u7528\u963f\u53f8\u5339\u6797\uff08<\/span>>325 mg\/<\/span>\u5929\uff09\u6216\u5176\u4ed6\u5df2\u77e5\u53ef\u4ee5\u6291\u5236\u8840\u5c0f\u677f\u529f\u80fd\u7684\u975e\u753e\u4f53\u6297\u708e\u836f\uff1b<\/span><\/span><\/p>\n

10  <\/span>\u5f53\u524d\u6216\u8fd1\u671f\uff08\u63a5\u53d7\u9996\u5242\u7814\u7a76\u836f\u7269\u524d<\/span>10<\/span>\u5929\u5185\uff09\u4f7f\u7528\u5168\u5242\u91cf\u53e3\u670d\u6216\u80c3\u80a0\u5916\u6297\u51dd\u8840\u836f\u6216\u8840\u6813\u6eb6\u89e3\u5242\u8fdb\u884c\u6cbb\u7597\u3002\u4f46\u5141\u8bb8\u9884\u9632\u6027\u4f7f\u7528\u6297\u51dd\u8840\u836f\uff1b<\/span><\/span><\/p>\n

11  <\/span>\u6709\u9057\u4f20\u6027\u51fa\u8840\u503e\u5411\u6216\u51dd\u8840\u529f\u80fd\u969c\u788d\uff0c\u6216\u8840\u6813\u75c5\u53f2\uff08\u7b5b\u9009\u524d<\/span>6<\/span>\u4e2a\u6708\u5185\uff09\uff1b<\/span><\/span><\/p>\n

12  <\/span>\u5728\u7b5b\u9009\u524d<\/span>3<\/span>\u4e2a\u6708\u5185\u6709\u54af\u8840\u53f2\uff0c\u54b3\u51fa\u7684\u8840\u91cf\u5927\u4e8e<\/span>2.5mL<\/span>\uff1b<\/span><\/span><\/p>\n

13  <\/span>\u672a\u63a7\u5236\u7684\u9ad8\u8840\u538b\uff08\u6536\u7f29\u538b\u5927\u4e8e<\/span>150 mmHg<\/span>\u548c<\/span>\/<\/span>\u6216\u8212\u5f20\u538b\u5927\u4e8e<\/span>100 mmHg<\/span>\uff09\u3001\u6709\u9ad8\u8840\u538b\u5371\u8c61\u6216\u9ad8\u8840\u538b\u8111\u75c5\u53f2\uff1b<\/span><\/span><\/p>\n

14  <\/span>\u4efb\u4f55\u4e0d\u7a33\u5b9a\u7684\u7cfb\u7edf\u6027\u75be\u75c5\uff1a\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u6d3b\u52a8\u6027\u611f\u67d3\uff08\u5c40\u90e8\u611f\u67d3\u9664\u5916\uff09\u3001\u4e0d\u7a33\u5b9a\u578b\u5fc3\u7ede\u75db\u3001\u8111\u8840\u7ba1\u610f\u5916\u6216\u77ed\u6682\u6027\u8111\u7f3a\u8840\uff08\u7b5b\u9009\u524d<\/span>6<\/span>\u4e2a\u6708\u5185\uff09\u3001\u5fc3\u808c\u6897\u6b7b\uff08\u7b5b\u9009\u524d<\/span>6<\/span>\u4e2a\u6708\u5185\uff09\u3001\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\uff08\u7ebd\u7ea6\u5fc3\u810f\u75c5\u534f\u4f1a<\/span>[NYHA]<\/span>\u5206\u7c7b\u2265<\/span>II<\/span>\u7ea7\uff09\u3001\u9700\u8981\u836f\u7269\u6cbb\u7597\u7684\u4e25\u91cd\u5fc3\u5f8b\u5931\u5e38\u3001\u809d\u810f\u3001\u80be\u810f\u6216\u4ee3\u8c22\u6027\u75be\u75c5\uff1b<\/span><\/span><\/p>\n

15  <\/span>\u7b5b\u9009\u524d<\/span>6<\/span>\u4e2a\u6708\u5185\u660e\u786e\u8bca\u65ad\u4ee5\u4e0b\u75c5\u53f2\uff1a\u6d88\u5316\u9053\u6e83\u75a1\u3001\u80c3\u80a0\u9053\u7a7f\u5b54\u3001\u8150\u8680\u6027\u98df\u7ba1\u708e\u6216\u80c3\u708e\u3001\u708e\u6027\u80a0\u75c5\u6216\u61a9\u5ba4\u708e\u3001\u8179\u7618\u3001\u6216\u8179\u8154\u5185\u8113\u80bf\uff1b<\/span><\/span><\/p>\n

16  <\/span>\u660e\u786e\u8bca\u65ad\u6709\u6c14\u7ba1<\/span>–<\/span>\u98df\u7ba1\u7618\uff1b<\/span><\/span><\/p>\n

17  <\/span>\u4e34\u5e8a\u4e0a\u663e\u8457\u7684\u7b2c\u4e09\u95f4\u9699\u79ef\u6db2\uff0c\u7ecf\u7814\u7a76\u8005\u5224\u65ad\u4e0d\u9002\u5408\u53c2\u4e0e\u672c\u7814\u7a76\u7684\uff08\u5982\u7ecf\u62bd\u6c34\u6216\u5176\u4ed6\u6cbb\u7597\u4ecd\u65e0\u6cd5\u63a7\u5236\u7684\u8179\u8154\u6216\u80f8\u8154\u79ef\u6db2\uff09\uff1b<\/span><\/span><\/p>\n

18  <\/span>\u6709\u80ba\u7ea4\u7ef4\u5316\u75c5\u53f2\u6216\u5728\u7b5b\u9009\u65f6<\/span>CT<\/span>\u663e\u793a\u6709\u6d3b\u52a8\u6027\u80ba\u708e\uff1b<\/span><\/span><\/p>\n

19  <\/span>\u5728\u968f\u673a\u5316\u524d<\/span>5<\/span>\u5e74\u5185\u60a3\u6709<\/span>NSCLC<\/span>\u4ee5\u5916\u7684\u6076\u6027\u80bf\u7624\uff0c\u9664\u4e86\u5145\u5206\u6cbb\u7597\u7684\u5bab\u9888\u539f\u4f4d\u764c\u3001\u57fa\u5e95\u7ec6\u80de\u6216\u9cde\u72b6\u4e0a\u76ae\u7ec6\u80de\u76ae\u80a4\u764c\u3001\u6839\u6cbb\u672f\u540e\u7684\u5c40\u90e8\u524d\u5217\u817a\u764c\u3001\u6839\u6cbb\u672f\u540e\u7684\u5bfc\u7ba1\u539f\u4f4d\u764c\uff1b<\/span><\/span><\/p>\n

20  <\/span>\u6709\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u53f2\uff1b<\/span><\/span><\/p>\n

21  <\/span>\u4e59\u809d\u8868\u9762\u6297\u539f\uff08<\/span>HBsAg<\/span>\uff09\u9633\u6027\u8005\uff0c\u4e14\u5916\u5468\u8840\u4e59\u809d\u75c5\u6bd2\u8131\u6c27\u6838\u7cd6\u6838\u9178\uff08<\/span>HBV DNA<\/span>\uff09\u6ef4\u5ea6\u68c0\u6d4b\u2265<\/span>1 <\/span>\u00d7<\/span> 104<\/span>\u62f7\u8d1d\u6570<\/span>\/L<\/span>\u7684\u53d7\u8bd5\u8005\uff1b\u82e5\u53d7\u8bd5\u8005<\/span>HBsAg<\/span>\u9633\u6027\uff0c\u4e14\u5916\u5468\u8840<\/span>HBV DNA<\/span>\u6ef4\u5ea6\u68c0\u6d4b<\/span><1 <\/span>\u00d7<\/span> 104<\/span>\u62f7\u8d1d\u6570<\/span>\/L<\/span>\uff0c\u5982\u679c\u7814\u7a76\u8005\u8ba4\u4e3a\u53d7\u8bd5\u8005\u6162\u6027\u4e59\u809d\u5904\u4e8e\u7a33\u5b9a\u671f\u4e14\u4e0d\u4f1a\u589e\u52a0\u53d7\u8bd5\u8005\u98ce\u9669\uff0c\u5219\u53d7\u8bd5\u8005\u53ef\u4ee5\u5165\u9009\uff1b<\/span><\/span><\/p>\n

22  <\/span>\u4e19\u578b\u809d\u708e\u75c5\u6bd2\uff08<\/span>HCV<\/span>\uff09\u6297\u4f53\u3001\u4eba\u4f53\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\uff08<\/span>HIV<\/span>\uff09\u6297\u4f53\u6216\u6885\u6bd2\u68c0\u6d4b\u9633\u6027\uff1b<\/span><\/span><\/p>\n

23  <\/span>\u5df2\u77e5\u6709\u53d8\u6001\u53cd\u5e94\u6027\u75be\u75c5\u75c5\u53f2\u6216\u4e3a\u8fc7\u654f\u4f53\u8d28\u8005\uff1b<\/span><\/span><\/p>\n

24  <\/span>\u7b5b\u9009\u524d<\/span>30<\/span>\u5929\u5185\u66fe\u63a5\u53d7\u5176\u5b83\u4efb\u4f55\u8bd5\u9a8c\u836f\u7269\u6cbb\u7597\u6216\u53c2\u52a0\u8fc7\u53e6\u4e00\u9879\u5e72\u9884\u6027\u4e34\u5e8a\u8bd5\u9a8c\uff1b<\/span><\/span><\/p>\n

25  <\/span>\u6709\u9157\u9152\u6216\u836f\u7269\u6ee5\u7528\u53f2\uff1b<\/span><\/span><\/p>\n

26  <\/span>\u598a\u5a20\u6216\u54fa\u4e73\u671f\u5973\u6027\u6216\u51c6\u5907\u5728\u7814\u7a76\u671f\u95f4\u598a\u5a20\u6216\u54fa\u4e73\u7684\u5973\u6027\uff1b<\/span><\/span><\/p>\n

27  <\/span>\u5df2\u77e5\u5bf9\u8d1d\u4f10\u73e0\u5355\u6297\u6216\u5176\u4efb\u4f55\u8f85\u6599\uff0c\u6216\u4efb\u4f55\u5316\u7597\u836f\u7269\u6210\u5206\u8fc7\u654f\uff1b<\/span><\/span><\/p>\n

28  <\/span>\u5176\u4ed6\u7814\u7a76\u8005\u8ba4\u4e3a\u4e0d\u9002\u5408\u5165\u7ec4\u7684\u60c5\u51b5\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

6.       <\/span><\/span>\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u5e8f\u53f7 <\/span><\/p>\n<\/td>\n

\n

\u673a\u6784\u540d\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u7814\u7a76\u8005 <\/span><\/p>\n<\/td>\n

\n

\u56fd\u5bb6 <\/span><\/p>\n<\/td>\n

\n

\u7701\uff08\u5dde\uff09 <\/span><\/p>\n<\/td>\n

\n

\u57ce\u5e02 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u738b\u6d01 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

2 <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u534f\u548c\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u738b\u9896\u8f76 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

3 <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5927\u5b66\u4eba\u6c11\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u66f9\u7167\u9f99 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

4 <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u8d75\u519b <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

5 <\/span><\/p>\n<\/td>\n

\n

\u6cb3\u5317\u533b\u79d1\u5927\u5b66\u7b2c\u56db\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u59dc\u8fbe <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6cb3\u5317 <\/span><\/p>\n<\/td>\n

\n

\u77f3\u5bb6\u5e84 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

6 <\/span><\/p>\n<\/td>\n

\n

\u5927\u8fde\u5e02\u4e2d\u5fc3\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u970d\u4f1f <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u8fbd\u5b81 <\/span><\/p>\n<\/td>\n

\n

\u5927\u8fde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

7 <\/span><\/p>\n<\/td>\n

\n

\u798f\u5efa\u7701\u7acb\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u5d14\u540c\u5065 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u798f\u5efa <\/span><\/p>\n<\/td>\n

\n

\u798f\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

8 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u5c71\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u90ed\u79b9\u6807 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5e7f\u4e1c <\/span><\/p>\n<\/td>\n

\n

\u5e7f\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

9 <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f\u7701\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u5f20\u6c82\u5e73 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f <\/span><\/p>\n<\/td>\n

\n

\u676d\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

10 <\/span><\/p>\n<\/td>\n

\n

\u5b89\u5fbd\u7701\u7acb\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u6f58\u8dc3\u94f6 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5b89\u5fbd <\/span><\/p>\n<\/td>\n

\n

\u5408\u80a5 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

11 <\/span><\/p>\n<\/td>\n

\n

\u5b89\u5fbd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u987e\u5eb7\u751f <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5b89\u5fbd <\/span><\/p>\n<\/td>\n

\n

\u5408\u80a5 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

12 <\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u65b0\u534e\u533b\u9662\u5d07\u660e\u5206\u9662 <\/span><\/p>\n<\/td>\n

\n

\u6768\u5fd7\u52c7 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77 <\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

13 <\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u745e\u91d1\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u65f6\u56fd\u671d <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77 <\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

14 <\/span><\/p>\n<\/td>\n

\n

\u6b66\u6c49\u5927\u5b66\u4e2d\u5357\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u5f20\u4fca\u7ea2 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6e56\u5317 <\/span><\/p>\n<\/td>\n

\n

\u6b66\u6c49 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

15 <\/span><\/p>\n<\/td>\n

\n

\u5409\u6797\u5927\u5b66\u4e2d\u65e5\u8054\u8c0a\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u767d\u5143\u677e <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5409\u6797 <\/span><\/p>\n<\/td>\n

\n

\u957f\u6625 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

16 <\/span><\/p>\n<\/td>\n

\n

\u6cb3\u5357\u7701\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u81e7\u51ef <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6cb3\u5357 <\/span><\/p>\n<\/td>\n

\n

\u90d1\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

17 <\/span><\/p>\n<\/td>\n

\n

\u91cd\u5e86\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u6c38\u5ddd\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u674e\u660e <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u91cd\u5e86 <\/span><\/p>\n<\/td>\n

\n

\u91cd\u5e86 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

18 <\/span><\/p>\n<\/td>\n

\n

\u54c8\u5c14\u6ee8\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u4e8e\u96c1 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u9ed1\u9f99\u6c5f <\/span><\/p>\n<\/td>\n

\n

\u54c8\u5c14\u6ee8 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

19 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u76db\u4eac\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u5434\u8363 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u8fbd\u5b81 <\/span><\/p>\n<\/td>\n

\n

\u6c88\u9633 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

20 <\/span><\/p>\n<\/td>\n

\n

\u65b0\u4e61\u533b\u5b66\u9662\u7b2c\u4e00\u9644\u5c5e\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u59ec\u9896\u534e <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6cb3\u5357 <\/span><\/p>\n<\/td>\n

\n

\u65b0\u4e61 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

21 <\/span><\/p>\n<\/td>\n

\n

\u676d\u5dde\u5e02\u7b2c\u4e00\u4eba\u6c11\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u738b\u5229\u6c11 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f <\/span><\/p>\n<\/td>\n

\n

\u676d\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

22 <\/span><\/p>\n<\/td>\n

\n

\u5b89\u5fbd\u7701\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u5f90\u7ea2\u53f6 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5b89\u5fbd <\/span><\/p>\n<\/td>\n

\n

\u5408\u80a5 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

23 <\/span><\/p>\n<\/td>\n

\n

\u5e7f\u5dde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e94\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u6797\u6625\u971e <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5e7f\u4e1c <\/span><\/p>\n<\/td>\n

\n

\u5e7f\u5dde <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u672c\u8bd5\u9a8c\u4fe1\u606f\u6765\u81ea<\/span>CFDA<\/span>\u201c\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u4e0e\u516c\u793a\u5e73\u53f0\u201d\u3002<\/span><\/span><\/p>\n

\u6b22\u8fce\u7533\u529e\u65b9\/CRO\/\u533b\u9662\u63d0\u4f9b\u80bf\u7624\u62db\u52df\u4fe1\u606f\uff0c\u53ef\u4ee5\u53d1\u90ae\u4ef6\u81f3LCSYZMXX@163.com\uff0c\u672c\u516c\u4f17\u53f7\u514d\u8d39\u63a8\u9001\u3002<\/span><\/p>\n

\n


<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u4fe1\u606f <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

1.       \u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb HL04\/WBP2 […]<\/p>\n","protected":false},"author":1,"featured_media":30087,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30086"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=30086"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30086\/revisions"}],"predecessor-version":[{"id":30092,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30086\/revisions\/30092"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/30087"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=30086"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=30086"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=30086"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}