{"id":30100,"date":"2018-08-04T01:00:00","date_gmt":"2018-08-09T04:05:50","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e3%80%90%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%85%e3%80%91%e5%9c%a8%e6%90%ba%e5%b8%a6flt3%e7%aa%81%e5%8f%98%e5%a4%8d%e5%8f%91%e6%80%a7%e6%88%96%e9%9a%be%e6%b2%bb%e6%80%a7%e6%80%a5%e6%80%a7%e9%ab%93\/"},"modified":"2018-08-09T12:05:51","modified_gmt":"2018-08-09T04:05:51","slug":"%e3%80%90%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%85%e3%80%91%e5%9c%a8%e6%90%ba%e5%b8%a6flt3%e7%aa%81%e5%8f%98%e5%a4%8d%e5%8f%91%e6%80%a7%e6%88%96%e9%9a%be%e6%b2%bb%e6%80%a7%e6%80%a5%e6%80%a7%e9%ab%93","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/30100\/","title":{"rendered":"\u3010\u62db\u52df\u60a3\u8005\u3011\u5728\u643a\u5e26FLT3\u7a81\u53d8\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u4e2d\u6bd4\u8f83ASP2215\u548c\u8865\u6551\u5316\u7597\u7684III\u671f\u3001\u5f00\u653e\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u7814\u7a76"},"content":{"rendered":"
\n
<\/mpcps><\/section>\n

<\/span><\/span>
<\/p>\n

1. <\/span>\u8bd5\u9a8c\u836f\u7269<\/span><\/span><\/p>\n

ASP2215<\/span>\u662f<\/span>FLT3\/Axl<\/span>\u6291\u5236\u5242\uff0c\u672c\u8bd5\u9a8c\u9002\u5e94\u75c7\u662f\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u3002<\/span><\/span><\/p>\n


<\/span><\/span><\/p>\n

2. <\/span>\u8bd5\u9a8c\u76ee\u7684<\/span><\/span><\/p>\n

\u4e3b\u8981\u76ee\u7684\u662f\u5728\u4e00\u7ebf<\/span>AML<\/span>\u6cbb\u7597\u540e\u590d\u53d1\u6216\u96be\u6cbb\u7684\u643a\u5e26<\/span>FMS<\/span>\u6837\u916a\u6c28\u9178\u6fc0\u9176\uff08<\/span>FLT3<\/span>\uff09\u7a81\u53d8<\/span>AML<\/span>\u53d7\u8bd5\u8005\u4e2d\u6d4b\u5b9a<\/span>ASP2215<\/span>\u6cbb\u7597\u8f83\u8865\u6551\u5316\u7597\u7684\u4e34\u5e8a\u83b7\u76ca\uff0c\u4ee5\u603b\u751f\u5b58\u671f\uff08<\/span>OS<\/span>\uff09\u8868\u793a\u3002<\/span><\/span><\/p>\n


<\/span><\/span><\/p>\n

3. <\/span>\u8bd5\u9a8c\u8bbe\u8ba1<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u5206\u7c7b\uff1a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/span><\/p>\n

\u8bd5\u9a8c\u5206\u671f\uff1a<\/span> III<\/span>\u671f<\/span><\/span><\/p>\n

\u8bbe\u8ba1\u7c7b\u578b\uff1a\u5e73\u884c\u5206\u7ec4<\/span><\/p>\n

\u968f\u673a\u5316\uff1a<\/span>   <\/span>\u968f\u673a\u5316<\/span><\/span><\/p>\n

\u76f2\u6cd5\uff1a<\/span>       <\/span>\u5f00\u653e<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u8303\u56f4\uff1a\u56fd\u9645\u591a\u4e2d\u5fc3\u8bd5\u9a8c<\/span> <\/span><\/span><\/p>\n

\u8bd5\u9a8c\u4eba\u6570\uff1a\u603b\u4f53<\/span>318<\/span>\u4eba\uff0c\u4e2d\u56fd<\/span>220<\/span>\u4eba<\/span><\/span><\/p>\n


<\/span><\/span><\/p>\n

4. <\/span>\u5165\u9009\u6807\u51c6\uff08\u5fc5\u987b\u5168\u90e8\u7b26\u5408\uff09<\/span><\/span><\/p>\n

1.    <\/span>\u5728\u8fdb\u884c\u4efb\u4f55\u7814\u7a76\u76f8\u5173\u7a0b\u5e8f\uff08\u5305\u62ec\u505c\u6b62\u7981\u7528\u836f\u7269\u6cbb\u7597\uff0c\u5982\u9002\u7528\uff09\u524d\uff0c\u53d7\u8bd5\u8005\u6216\u6cd5\u5b9a\u4ee3\u7406\u4eba\u5e94\u7b7e\u7f72\u673a\u6784\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08<\/span>IRB<\/span>\uff09<\/span>\/<\/span>\u72ec\u7acb\u4f26\u7406\u59d4\u5458\u4f1a\uff08<\/span>IEC<\/span>\uff09\u6279\u51c6\u7684\u77e5\u60c5\u540c\u610f\u4e66\u548c\u7b26\u5408\u56fd\u5bb6\u6cd5\u89c4\u7684\u4fdd\u5bc6\u6761\u6b3e\u3002<\/span><\/span><\/p>\n

2.    <\/span>\u53d7\u8bd5\u8005\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\u65f6\uff0c\u4f9d\u636e\u5f53\u5730\u6cd5\u5f8b\uff0c\u88ab\u8ba4\u4e3a\u662f\u6210\u5e74\u4eba\uff08\u4f8b\u5982\u5728\u4e2d\u56fd\uff0c\u5e74\u9f84<\/span>\u226518<\/span>\u5c81\uff09\u3002<\/span><\/span><\/p>\n

3.    <\/span>\u6cbb\u7597\u673a\u6784\u5bf9\u53d7\u8bd5\u8005\u8fdb\u884c\u75c5\u7406\u5b66\u5ba1\u67e5\uff0c\u5176\u8bca\u65ad\u7ed3\u679c\u7b26\u5408\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u5206\u7c7b<\/span>[Swerdlow et al, 2008]<\/span>\u4e2d\u7684\u539f\u53d1\u6027<\/span>AML<\/span>\u6216\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u5f81\uff08<\/span>MDS<\/span>\uff09\u7ee7\u53d1\u6027<\/span>AML<\/span>\u3002<\/span><\/span><\/p>\n

4.    <\/span>\u53d7\u8bd5\u8005\u63a5\u53d7\u4e00\u7ebf<\/span>AML<\/span>\u6cbb\u7597\uff08\u8fdb\u884c\u6216\u672a\u8fdb\u884c<\/span>HSCT<\/span>\uff09\u540e\u51fa\u73b0\u96be\u6cbb\u6216\u590d\u53d1\uff08\u53c2\u8003\u9644\u5f55<\/span>12.6<\/span>\uff0c\u6cbb\u7597\u79cd\u7c7b\u5b9a\u4e49\uff09\u3002<\/span><\/span><\/p>\n

\u25cf     <\/span>\u4e00\u7ebf<\/span>AML<\/span>\u6cbb\u7597\u96be\u6cbb\u5b9a\u4e49\u4e3a\uff1a<\/span><\/span><\/p>\n

a.     <\/span>\u521d\u59cb\u6cbb\u7597\u540e\u53d7\u8bd5\u8005\u672a\u8fbe\u5230<\/span>CR\/CRi\/CRp<\/span>\u3002\u9002\u5408\u8fdb\u884c\u6807\u51c6\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u5e94\u63a5\u53d7\u81f3\u5c11<\/span>1<\/span>\u4e2a\u5468\u671f\u7684\u84bd\u73af\u7c7b\u836f\u7269\u6cbb\u7597\uff08\u542b\u6240\u9009\u8bf1\u5bfc\u65b9\u6848\u4e2d\u6807\u51c6\u5242\u91cf\u7684\u8bf1\u5bfc\u6cbb\u7597\uff09\u3002\u4e0d\u9002\u5408\u8fdb\u884c\u6807\u51c6\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u5e94\u6309\u7167\u7814\u7a76\u8005\u8bc4\u4f30\u7ed3\u679c\u63a5\u53d7\u81f3\u5c11<\/span>1<\/span>\u7ec4\u5b8c\u6574\u7684\u8bf1\u5bfc\u6cbb\u7597\uff08\u6700\u4f73\u9009\u62e9\u6cbb\u7597\uff09\uff0c\u4ee5\u8bf1\u5bfc\u53d7\u8bd5\u8005\u4ea7\u751f\u7f13\u89e3\u3002<\/span><\/span><\/p>\n

\u25cf     <\/span>\u7b2c\u4e00\u6b21\u6cbb\u7597\u540e\u8840\u6db2\u5b66\u590d\u53d1\uff0c\u5e76\u4e14\u672a\u9488\u5bf9\u8be5\u6b21\u590d\u53d1\u8fdb\u884c\u6cbb\u7597\uff0c\u5b9a\u4e49\u4e3a\uff1a<\/span><\/span><\/p>\n

a.     <\/span>\u53d7\u8bd5\u8005\u4e00\u7ebf\u6cbb\u7597\u5fc5\u987b\u8fbe\u5230<\/span>CR\/CRi\/CRp<\/span>\uff08\u6309\u7167<\/span>[Cheson et al, 2003]<\/span>\u5b9a\u4e49\uff0c\u89c1\u7b2c<\/span>5.3<\/span>\u8282\uff09\uff0c\u5e76\u4e14\u8840\u6db2\u5b66\u590d\u53d1\u3002<\/span><\/span><\/p>\n

5.    <\/span>\u7531\u4e2d\u5fc3\u5b9e\u9a8c\u5ba4\u68c0\u6d4b\u786e\u8ba4\u53d7\u8bd5\u8005\u9aa8\u9ad3\u6216\u5168\u8840<\/span>FLT3<\/span>\u7a81\u53d8\u9633\u6027\u3002\u5982\u679c\u6839\u636e\u7814\u7a76\u8005\u5224\u65ad\uff0c\u53d7\u8bd5\u8005\u75be\u75c5\u5904\u4e8e\u5feb\u901f\u589e\u6b96\u72b6\u6001\uff0c\u65e0\u6cd5\u7b49\u5f85\u4e2d\u5fc3\u5b9e\u9a8c\u5ba4\u7684\u8bd5\u9a8c\u7ed3\u679c\uff0c\u5219\u53ef\u4ee5\u6839\u636e\u53d7\u8bd5\u8005\u672b\u6b21\u5e72\u9884\u6027\u6cbb\u7597\u7ed3\u675f\u540e\u8fdb\u884c\u7684\u5f53\u5730\u5b9e\u9a8c\u5ba4\u68c0\u6d4b\u7ed3\u679c\u5165\u7ec4\u53d7\u8bd5\u8005\u3002\u5982\u679c\u5f53\u5730\u5b9e\u9a8c\u5ba4\u68c0\u6d4b\u7ed3\u679c\u663e\u793a\u53d7\u8bd5\u8005\u6709\u4ee5\u4e0b\u4efb\u4f55<\/span>FLT3<\/span>\u7a81\u53d8\u7c7b\u578b\uff0c\u5219\u53ef\u4ee5\u5165\u7ec4\uff1a<\/span>FLT3<\/span>\u5185\u90e8\u4e32\u8054\u91cd\u590d\uff08<\/span>ITD<\/span>\uff09\u3001<\/span>FLT3<\/span>\u916a\u6c28\u9178\u6fc0\u9176\u57df\uff08<\/span>TKD<\/span>\uff09<\/span>\/D835<\/span>\u6216<\/span> FLT3-fTKD\/I836<\/span>\u3002<\/span><\/span><\/p>\n

6.    <\/span>\u53d7\u8bd5\u8005<\/span>ECOG<\/span>\u4f53\u529b\u72b6\u6001\u8bc4\u5206<\/span>\u22642<\/span>\u3002<\/span><\/span><\/p>\n

7.    <\/span>\u7814\u7a76\u8005\u8bc4\u4f30\u540e\u8ba4\u4e3a\u53d7\u8bd5\u8005\u9002\u5408\u63a5\u53d7\u4e8b\u5148\u9009\u5b9a\u7684\u8865\u6551\u5316\u7597\u3002<\/span><\/span><\/p>\n

8.    <\/span>\u53d7\u8bd5\u8005\u7684\u4e34\u5e8a\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u7ed3\u679c\u5e94\u7b26\u5408\u4ee5\u4e0b\u6807\u51c6\uff1a<\/span><\/span><\/p>\n

\u25cf     <\/span>\u8840\u6e05\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\u548c\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176<\/span>\u22642.5 x<\/span>\u6b63\u5e38\u503c\u4e0a\u9650\uff08<\/span>ULN<\/span>\uff09\u3002<\/span><\/span><\/p>\n

\u25cf     <\/span>\u8840\u6e05\u603b\u80c6\u7ea2\u7d20<\/span>\u22641.5 x ULN<\/span><\/span><\/p>\n

\u25cf     <\/span>\u8840\u6e05\u808c\u9150<\/span>\u22641.5 x ULN<\/span>\uff0c\u6216\u91c7\u7528\u80be\u810f\u75be\u75c5\u996e\u98df\u6539\u826f\u7b80\u5316\u516c\u5f0f<\/span>[Levey et al, 1999]<\/span>\u4f30\u7b97\u7684\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387<\/span>> 50 mL\/min<\/span>\u3002<\/span><\/span><\/p>\n

9.    <\/span>\u53d7\u8bd5\u8005\u9002\u5408\u53e3\u670d\u7814\u7a76\u836f\u7269\u3002<\/span><\/span><\/p>\n

10.   <\/span>\u5973\u6027\u53d7\u8bd5\u8005\u5e94\u7b26\u5408\u4e0b\u8ff0\u8981\u6c42\u4e4b\u4e00\uff1a<\/span><\/span><\/p>\n

\u25cf     <\/span>\u65e0\u751f\u80b2\u80fd\u529b\uff1a<\/span><\/span><\/p>\n

\u25cf     <\/span>\u7b5b\u9009\u524d\u7edd\u7ecf\uff08\u5b9a\u4e49\u4e3a\u81f3\u5c11<\/span>1<\/span>\u5e74\u6ca1\u6709\u6708\u7ecf\uff09\uff0c\u6216<\/span><\/span><\/p>\n

\u25cf     <\/span>\u8bc1\u5b9e\u5df2\u884c\u7edd\u80b2\u624b\u672f\uff08\u7b5b\u9009\u524d\u81f3\u5c11<\/span>1<\/span>\u4e2a\u6708\uff09<\/span><\/span><\/p>\n

\u25cf     <\/span>\u6216\uff0c\u5982\u679c\u5177\u6709\u751f\u80b2\u80fd\u529b\uff1a<\/span><\/span><\/p>\n

\u25cf     <\/span>\u540c\u610f\u5728\u7814\u7a76\u671f\u95f4\u4ee5\u53ca\u7814\u7a76\u836f\u7269\u672b\u6b21\u7ed9\u836f\u540e<\/span>60<\/span>\u5929\u5185\u907f\u5b55\uff0c\u4e14<\/span><\/span><\/p>\n

\u25cf     <\/span>\u7b5b\u9009\u65f6\u5c3f\u598a\u5a20\u8bd5\u9a8c\u5448\u9634\u6027\uff0c\u4e14<\/span><\/span><\/p>\n

\u25cf     <\/span>\u81ea\u7b5b\u9009\u8d77\u5728\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u76f4\u81f3\u7814\u7a76\u836f\u7269\u672b\u6b21\u7ed9\u836f\u540e<\/span>60<\/span>\u5929\uff0c\u5982\u679c\u4e0e\u5f02\u6027\u53d1\u751f\u6027\u884c\u4e3a\uff0c\u540c\u610f\u59cb\u7ec8\u4f7f\u7528\u6709\u6548\u7684\u5f53\u5730\u516c\u8ba4\u7684\u9664\u5c4f\u969c\u907f\u5b55\u6cd5\u4e4b\u5916\u7684\u53e6\u4e00\u79cd\u6807\u51c6\u907f\u5b55\u65b9\u6cd5\u3002<\/span><\/span><\/p>\n

11.   <\/span>\u81ea\u7b5b\u9009\u8d77\u5728\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u76f4\u81f3\u7814\u7a76\u836f\u7269\u672b\u6b21\u7ed9\u836f\u540e<\/span>60<\/span>\u5929\uff0c\u5973\u6027\u53d7\u8bd5\u8005\u4e0d\u5f97\u54fa\u4e73\u3002<\/span><\/span><\/p>\n

12.   <\/span>\u81ea\u7b5b\u9009\u8d77\u5728\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u76f4\u81f3\u7814\u7a76\u836f\u7269\u672b\u6b21\u7ed9\u836f\u540e<\/span>60<\/span>\u5929\uff0c\u5973\u6027\u53d7\u8bd5\u8005\u4e0d\u5f97\u6350\u732e\u5375\u5b50\u3002<\/span><\/span><\/p>\n

13.   <\/span>\u81ea\u7b5b\u9009\u8d77\u5728\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u76f4\u81f3\u7814\u7a76\u836f\u7269\u672b\u6b21\u7ed9\u836f\u540e<\/span>120<\/span>\u5929\uff0c\u7537\u6027\u53d7\u8bd5\u8005\u53ca\u5176\u5177\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u4f34\u4fa3\u5e94\u4f7f\u7528\u9ad8\u5ea6\u6709\u6548\u7684\u5f53\u5730\u516c\u8ba4\u7684\u9664\u5c4f\u969c\u907f\u5b55\u6cd5\u4e4b\u5916\u7684\u53e6\u4e00\u79cd\u6807\u51c6\u907f\u5b55\u65b9\u6cd5\u3002<\/span><\/span><\/p>\n

14.   <\/span>\u81ea\u7b5b\u9009\u8d77\u5728\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u76f4\u81f3\u7814\u7a76\u836f\u7269\u672b\u6b21\u7ed9\u836f\u540e<\/span>120<\/span>\u5929\uff0c\u7537\u6027\u53d7\u8bd5\u8005\u4e0d\u5f97\u6350\u732e\u7cbe\u5b50\u3002<\/span><\/span><\/p>\n

15.   <\/span>\u53d7\u8bd5\u8005\u540c\u610f\u5728\u6cbb\u7597\u671f\u95f4\u4e0d\u53c2\u52a0\u5176\u5b83\u5e72\u9884\u6027\u7814\u7a76\u3002<\/span><\/span><\/p>\n


<\/span><\/span><\/p>\n

5. <\/span>\u6392\u9664\u6807\u51c6\uff08\u5fc5\u987b\u5168\u90e8\u4e0d\u7b26\u5408\uff09<\/span><\/span><\/p>\n

1.    <\/span>\u53d7\u8bd5\u8005\u88ab\u8bca\u65ad\u4e3a\u6025\u6027\u65e9\u5e7c\u7c92\u7ec6\u80de\u767d\u8840\u75c5\u3002<\/span><\/span><\/p>\n

2.    <\/span>\u53d7\u8bd5\u8005\u60a3\u6709<\/span>BCR-ABL<\/span>\u9633\u6027\u767d\u8840\u75c5\uff08\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\u6025\u53d8\uff09\u3002<\/span><\/span><\/p>\n

3.    <\/span>\u53d7\u8bd5\u8005\u65e2\u5f80\u63a5\u53d7\u5176\u5b83\u80bf\u7624\uff08\u9664<\/span>MDS<\/span>\uff09\u5316\u7597\u540e\u51fa\u73b0\u7ee7\u53d1\u6027<\/span>AML<\/span>\u3002<\/span><\/span><\/p>\n

4.    <\/span>\u53d7\u8bd5\u8005\u5728\u4e8c\u7ebf\u6216\u4e4b\u540e\u7684\u6cbb\u7597\u4e2d\u51fa\u73b0\u8840\u6db2\u5b66\u590d\u53d1\uff0c\u6216\u63a5\u53d7\u8fc7\u9488\u5bf9\u96be\u6cbb\u6027\u75be\u75c5\u7684\u633d\u6551\u6cbb\u7597\u3002<\/span><\/span><\/p>\n

5.    <\/span>\u53d7\u8bd5\u8005\u5177\u6709\u6d3b\u52a8\u6027\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u767d\u8840\u75c5\u3002<\/span><\/span><\/p>\n

6.    <\/span>\u53d7\u8bd5\u8005\u88ab\u8bca\u65ad\u51fa\u53e6\u4e00\u79cd\u6076\u6027\u80bf\u7624\uff0c\u9664\u975e\u65e0\u75c5\u751f\u5b58\u671f\u81f3\u5c11\u4e3a<\/span>5<\/span>\u5e74\u3002\u5bf9\u4e8e\u975e\u9ed1\u8272\u7d20\u76ae\u80a4\u764c\u3001\u539f\u4f4d\u764c\u6216\u5bab\u9888\u4e0a\u76ae\u5185\u7624\u6837\u75c5\u53d8\u7ecf\u6cbb\u53d7\u8bd5\u8005\uff08\u4e0d\u8003\u8651\u5176\u65e0\u75c5\u751f\u5b58\u671f\uff09\uff0c\u5982\u679c\u5df2\u5b8c\u6210\u6839\u6cbb\u6027\u6cbb\u7597\uff0c\u5219\u6709\u8d44\u683c\u53c2\u52a0\u7814\u7a76\u3002\u5bf9\u4e8e\u60a3\u6709\u5c40\u9650\u4e8e\u524d\u5217\u817a\u5185\u7684\u524d\u5217\u817a\u764c\u4e14\u65e0\u75be\u75c5\u590d\u53d1\u6216\u8fdb\u5c55\u8bc1\u636e\u7684\u53d7\u8bd5\u8005\uff0c\u5982\u679c\u5df2\u7ecf\u5f00\u59cb\u63a5\u53d7\u6fc0\u7d20\u6cbb\u7597\u6216\u662f\u624b\u672f\u5207\u9664\u4e86\u6076\u6027\u80bf\u7624\u6216\u5df2\u884c\u6839\u6cbb\u6027\u653e\u7597\uff0c\u5219\u6709\u8d44\u683c\u53c2\u52a0\u7814\u7a76\u3002<\/span><\/span><\/p>\n

7.    <\/span>\u53d7\u8bd5\u8005\u65e2\u5f80\u63a5\u53d7\u8fc7<\/span>ASP2215<\/span>\u6216\u5176\u5b83<\/span>FLT3<\/span>\u6291\u5236\u5242\uff08\u9664\u4e86\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u4e2d\u4f5c\u4e3a\u8bf1\u5bfc\u3001\u5de9\u56fa\u548c\uff0f\u6216\u7ef4\u6301\u6cbb\u7597\u7684\u7d22\u62c9\u83f2\u5c3c\u548c\u7c73\u54da\u59a5\u6797\uff09\u6cbb\u7597\u3002<\/span><\/span><\/p>\n

8.    <\/span>\u53d7\u8bd5\u8005\u5b58\u5728\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u51dd\u8840\u5f02\u5e38\uff0c\u4f8b\u5982\u5f25\u6f2b\u6027\u8840\u7ba1\u5185\u51dd\u8840\u3002<\/span><\/span><\/p>\n

9.    <\/span>\u53d7\u8bd5\u8005\u5728\u7814\u7a76\u9996\u6b21\u7ed9\u836f\u524d<\/span>4<\/span>\u5468\u5185\u8fdb\u884c\u8fc7\u5927\u624b\u672f\u3002<\/span><\/span><\/p>\n

10.   <\/span>\u53d7\u8bd5\u8005\u5728\u7814\u7a76\u9996\u6b21\u7ed9\u836f\u524d<\/span>4<\/span>\u5468\u5185\u8fdb\u884c\u8fc7\u653e\u7597\u3002<\/span><\/span><\/p>\n

11.   <\/span>\u5982\u679c\u53d7\u8bd5\u8005\u60a3\u6709\u7ebd\u7ea6\u5fc3\u810f\u534f\u4f1a\uff08<\/span>NYHA<\/span>\uff09<\/span>3<\/span>\u7ea7\u6216<\/span>4<\/span>\u7ea7\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\uff0c\u6216\u65e2\u5f80\u6709<\/span>NYHA 3<\/span>\u7ea7\u6216<\/span>4<\/span>\u7ea7\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\u75c5\u53f2\uff0c\u9664\u975e\u5176\u5728\u8fdb\u5165\u7814\u7a76\u524d<\/span>1<\/span>\u4e2a\u6708\u5185\u8fdb\u884c\u7684\u8d85\u58f0\u5fc3\u52a8\u56fe\u7b5b\u9009\u4e2d\u5de6\u5fc3\u5ba4\u5c04\u8840\u5206\u6570\uff08<\/span>LVEF<\/span>\uff09<\/span>\u226545%<\/span>\uff0c\u5426\u5219\u4e0d\u5f97\u53c2\u52a0\u7814\u7a76\u3002<\/span><\/span><\/p>\n

12.   <\/span>\u6839\u636e\u4e2d\u5fc3\u8bfb\u56fe\u7ed3\u679c\uff0c\u7b5b\u9009\u65f6\u53d7\u8bd5\u8005\u7684<\/span>3<\/span>\u6b21<\/span>Fridericia<\/span>\u6821\u6b63<\/span>QT<\/span>\u95f4\u671f\uff08<\/span>QTcF<\/span>\uff09\u7684\u5e73\u5747\u503c<\/span>>450 ms<\/span>\u3002<\/span><\/span><\/p>\n

13.   <\/span>\u7b5b\u9009\u65f6\u53d7\u8bd5\u8005\u6709<\/span>QT<\/span>\u95f4\u671f\u5ef6\u957f\u7efc\u5408\u5f81\u3002<\/span><\/span><\/p>\n

14.   <\/span>\u7b5b\u9009\u65f6\u53d7\u8bd5\u8005\u6709\u4f4e\u94be\u8840\u75c7\u6216\u4f4e\u9541\u8840\u75c7\uff08\u5b9a\u4e49\u4e3a\u68c0\u67e5\u7ed3\u679c\u4f4e\u4e8e\u6b63\u5e38\u503c\u4e0b\u9650<\/span>[LLN]<\/span>\uff09\u3002<\/span><\/span><\/p>\n

15.   <\/span>\u53d7\u8bd5\u8005\u9700\u8981\u5408\u5e76\u4f7f\u7528\u7ec6\u80de\u8272\u7d20<\/span>P450 (CYP) 3A<\/span>\u5f3a\u6548\u8bf1\u5bfc\u5242\u3002<\/span><\/span><\/p>\n

16.   <\/span>\u53d7\u8bd5\u8005\u9700\u8981\u5408\u5e76\u4f7f\u7528<\/span>P-<\/span>\u7cd6\u86cb\u767d\uff08<\/span>P-gp<\/span>\uff09\u5f3a\u6548\u6291\u5236\u5242\u6216\u8bf1\u5bfc\u5242\uff0c\u9664\u975e\u8ba4\u4e3a\u53d7\u8bd5\u8005\u6cbb\u7597\u65b9\u6848\u4e2d\u5fc5\u9700\u4f7f\u7528\u8be5\u836f\u7269\u3002<\/span><\/span><\/p>\n

17.   <\/span>\u53d7\u8bd5\u8005\u9700\u8981\u5408\u5e76\u4f7f\u7528\u8840\u6e05\u7d20<\/span>5-<\/span>\u7f9f\u8272\u80fa\u53d7\u4f53<\/span>1<\/span>\uff08<\/span>5HT1R<\/span>\uff09\u6216<\/span>5-<\/span>\u7f9f\u8272\u80fa\u53d7\u4f53<\/span>2B<\/span>\uff08<\/span>5HT2BR<\/span>\uff09\u6216<\/span>\u03c3<\/span>\u975e\u7279\u5f02\u6027\u53d7\u4f53\u7684\u9776\u5411\u6027\u836f\u7269\uff0c\u9664\u975e\u8ba4\u4e3a\u53d7\u8bd5\u8005\u6cbb\u7597\u65b9\u6848\u4e2d\u5fc5\u9700\u4f7f\u7528\u8be5\u836f\u7269\u3002<\/span><\/span><\/p>\n

18.   <\/span>\u53d7\u8bd5\u8005\u6709\u65e0\u6cd5\u63a7\u5236\u7684\u6d3b\u52a8\u6027\u611f\u67d3\u3002<\/span><\/span><\/p>\n

19.   <\/span>\u5df2\u77e5\u53d7\u8bd5\u8005\u611f\u67d3\u4e86\u4eba\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\u3002<\/span><\/span><\/p>\n

20.   <\/span>\u53d7\u8bd5\u8005\u60a3\u6709\u6d3b\u52a8\u6027\u4e59\u809d\u6216\u4e19\u809d\u6216\u5176\u5b83\u6d3b\u52a8\u6027\u809d\u810f\u75be\u75c5\u3002<\/span><\/span><\/p>\n

21.   <\/span>\u7814\u7a76\u8005\u8ba4\u4e3a\u53d7\u8bd5\u8005\u5b58\u5728\u4efb\u4f55\u4e0d\u9002\u5408\u53c2\u52a0\u7814\u7a76\u7684\u60c5\u51b5\u3002<\/span><\/span><\/p>\n

22.   <\/span>\u53d7\u8bd5\u8005\u5177\u6709\u6d3b\u52a8\u6027\u7684\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684<\/span>GVHD<\/span>\u6216\u6b63\u5728\u4f7f\u7528\u6cbb\u7597<\/span>GVHD<\/span>\u7684\u5168\u8eab\u6027\u76ae\u8d28\u7c7b\u56fa\u9187\u7c7b\u836f\u7269\u3002<\/span><\/span><\/p>\n

23.   <\/span>\u53d7\u8bd5\u8005\u5177\u6709\u9664\u4e0b\u8ff0\u4e4b\u5916\u7684<\/span>FLT3<\/span>\u7a81\u53d8\uff1a<\/span>FLT3-ITD<\/span>\u3001<\/span>FLT3-TKD\/D835<\/span>\u6216<\/span>FLT3-TKD\/I836<\/span><\/span><\/p>\n

\u4e0d\u5141\u8bb8\u5b9e\u884c\u6392\u9664\u6807\u51c6\u8c41\u514d\u3002<\/span><\/p>\n

<\/span><\/span><\/p>\n

6. <\/span>\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u5e8f\u53f7<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u673a\u6784\u540d\u79f0<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u7814\u7a76\u8005<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u7701\u4efd<\/span><\/strong><\/span><\/p>\n<\/td>\n

\n

\u7701\u4efd<\/span><\/strong><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1<\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u8840\u6db2\u7814\u7a76\u6240\u8840\u6db2\u75c5\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u738b\u5efa\u7965<\/span><\/p>\n<\/td>\n

\n

\u5929\u6d25\u5e02<\/span><\/p>\n<\/td>\n

\n

\u5929\u6d25\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

2<\/span><\/p>\n<\/td>\n

\n

\u5e7f\u4e1c\u7701\u4eba\u6c11\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u675c\u6b23<\/span><\/p>\n<\/td>\n

\n

\u5e7f\u4e1c\u7701<\/span><\/p>\n<\/td>\n

\n

\u5e7f\u5dde\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

3<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u534f\u548c\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u674e\u5251<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

4<\/span><\/p>\n<\/td>\n

\n

\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u540c\u6d4e\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u5468\u5251\u5cf0<\/span><\/p>\n<\/td>\n

\n

\u6e56\u5317\u7701<\/span><\/p>\n<\/td>\n

\n

\u6b66\u6c49\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

5<\/span><\/p>\n<\/td>\n

\n

\u9752\u5c9b\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u8d75\u6625\u4ead<\/span><\/p>\n<\/td>\n

\n

\u5c71\u4e1c\u7701<\/span><\/p>\n<\/td>\n

\n

\u9752\u5c9b\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

6<\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u91d1\u6d01<\/span><\/p>\n<\/td>\n

\n

\u6d59\u6c5f\u7701<\/span><\/p>\n<\/td>\n

\n

\u676d\u5dde\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

7<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5927\u5b66\u4eba\u6c11\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u6c5f\u6d69<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

8<\/span><\/p>\n<\/td>\n

\n

\u9996\u90fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u5317\u4eac\u53cb\u8c0a\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u738b\u662d<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

9<\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd\u4eba\u6c11\u89e3\u653e\u519b\u603b\u533b\u9662<\/span> (301)<\/span><\/p>\n<\/td>\n

\n

\u5218\u4ee3\u7ea2<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

10<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5927\u5b66\u7b2c\u4e09\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u514b\u6653\u71d5<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

11<\/span><\/p>\n<\/td>\n

\n

\u6cb3\u5357\u7701\u80bf\u7624\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u9b4f\u65ed\u4e1c<\/span><\/p>\n<\/td>\n

\n

\u6cb3\u5357\u7701<\/span><\/p>\n<\/td>\n

\n

\u90d1\u5dde\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

12<\/span><\/p>\n<\/td>\n

\n

\u4e2d\u5c71\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u674e\u5a1f<\/span><\/p>\n<\/td>\n

\n

\u5e7f\u4e1c\u7701<\/span><\/p>\n<\/td>\n

\n

\u5e7f\u5dde\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

13<\/span><\/p>\n<\/td>\n

\n

\u5409\u6797\u5927\u5b66\u7b2c\u4e00\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u9ad8\u7d20\u541b<\/span><\/p>\n<\/td>\n

\n

\u5409\u6797\u7701<\/span><\/p>\n<\/td>\n

\n

\u957f\u6625\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

14<\/span><\/p>\n<\/td>\n

\n

\u5c71\u4e1c\u7701\u7acb\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u738b\u6b23<\/span><\/p>\n<\/td>\n

\n

\u5c71\u4e1c\u7701<\/span><\/p>\n<\/td>\n

\n

\u6d4e\u5357\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

15<\/span><\/p>\n<\/td>\n

\n

\u5b89\u5fbd\u7701\u7acb\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u5218\u6b23<\/span><\/p>\n<\/td>\n

\n

\u5b89\u5fbd\u7701<\/span><\/p>\n<\/td>\n

\n

\u5408\u80a5\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

16<\/span><\/p>\n<\/td>\n

\n

\u798f\u5efa\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u534f\u548c\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u80e1\u5efa\u8fbe<\/span><\/p>\n<\/td>\n

\n

\u798f\u5efa\u7701<\/span><\/p>\n<\/td>\n

\n

\u798f\u5dde\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

17<\/span><\/p>\n<\/td>\n

\n

\u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u4e09\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u5218\u7ade<\/span><\/p>\n<\/td>\n

\n

\u6e56\u5357\u7701<\/span><\/p>\n<\/td>\n

\n

\u957f\u6c99\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

18<\/span><\/p>\n<\/td>\n

\n

\u5357\u65b9\u533b\u79d1\u5927\u5b66\u5357\u65b9\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u5f20\u94b0<\/span><\/p>\n<\/td>\n

\n

\u5e7f\u4e1c\u7701<\/span><\/p>\n<\/td>\n

\n

\u5e7f\u5dde\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

19<\/span><\/p>\n<\/td>\n

\n

\u897f\u5b89\u4ea4\u901a\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u5f20\u6885<\/span><\/p>\n<\/td>\n

\n

\u9655\u897f\u7701<\/span><\/p>\n<\/td>\n

\n

\u897f\u5b89\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

20<\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u745e\u91d1\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u674e\u519b\u6c11<\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77\u5e02<\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

21<\/span><\/p>\n<\/td>\n

\n

\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u540c\u6d4e\u533b\u5b66\u9662\u9644\u5c5e\u534f\u548c\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u80e1\u8c6b<\/span><\/p>\n<\/td>\n

\n

\u6e56\u5317\u7701<\/span><\/p>\n<\/td>\n

\n

\u6b66\u6c49\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

22<\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u674e\u8273<\/span><\/p>\n<\/td>\n

\n

\u8fbd\u5b81\u7701<\/span><\/p>\n<\/td>\n

\n

\u6c88\u9633\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

23<\/span><\/p>\n<\/td>\n

\n

\u82cf\u5317\u4eba\u6c11\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u987e\u5065<\/span><\/p>\n<\/td>\n

\n

\u6c5f\u82cf\u7701<\/span><\/p>\n<\/td>\n

\n

\u626c\u5dde\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

24<\/span><\/p>\n<\/td>\n

\n

\u5357\u4eac\u9f13\u697c\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u9648\u5175<\/span><\/p>\n<\/td>\n

\n

\u6c5f\u82cf\u7701<\/span><\/p>\n<\/td>\n

\n

\u5357\u4eac\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

25<\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u540c\u4ec1\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u5218\u7acb\u6839<\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77\u5e02<\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

26<\/span><\/p>\n<\/td>\n

\n

\u8d35\u5dde\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u738b\u5b63\u77f3<\/span><\/p>\n<\/td>\n

\n

\u8d35\u5dde\u7701<\/span><\/p>\n<\/td>\n

\n

\u8d35\u9633\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

27<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5927\u5b66\u56fd\u9645\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u6c5f\u6ee8<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02<\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

28<\/span><\/p>\n<\/td>\n

\n

\u6f33\u5dde\u5e02\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u6797\u806a\u731b<\/span><\/p>\n<\/td>\n

\n

\u798f\u5efa\u7701<\/span><\/p>\n<\/td>\n

\n

\u6f33\u5dde\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

29<\/span><\/p>\n<\/td>\n

\n

\u5170\u5dde\u5927\u5b66\u7b2c\u4e8c\u9644\u5c5e\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

\u5f20\u8fde\u751f<\/span><\/p>\n<\/td>\n

\n

\u7518\u8083\u7701<\/span><\/p>\n<\/td>\n

\n

\u5170\u5dde\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

30<\/span><\/p>\n<\/td>\n

\n

\u4e2d\u5c71\u5927\u5b66\u5b59\u9038\u4ed9\u7eaa\u5ff5\u533b\u9662<\/span><\/p>\n<\/td>\n

\n

 \u8042\u5927\u5e74<\/span><\/span><\/p>\n<\/td>\n

\n

\u5e7f\u4e1c\u7701<\/span><\/p>\n<\/td>\n

\n

\u5e7f\u5dde\u5e02<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/span><\/p>\n


<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u4fe1\u606f <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

1. \u8bd5\u9a8c\u836f\u7269 ASP2215\u662fFLT3\/Axl\u6291\u5236\u5242\uff0c\u672c\u8bd5\u9a8c\u9002\u5e94\u75c7\u662f\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u3002 2. \u8bd5\u9a8c\u76ee\u7684 \u4e3b\u8981\u76ee […]<\/p>\n","protected":false},"author":1,"featured_media":30101,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30100"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=30100"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30100\/revisions"}],"predecessor-version":[{"id":30106,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30100\/revisions\/30106"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/30101"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=30100"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=30100"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=30100"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}