{"id":30107,"date":"2018-08-02T01:00:00","date_gmt":"2018-08-09T04:05:53","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e3%80%90%e7%bf%b0%e4%b8%adpd-1%e6%8b%9b%e5%8b%9f2%e3%80%91%e9%87%8d%e7%bb%84%e4%ba%ba%e6%ba%90%e5%8c%96%e6%8a%97-pd-1-%e5%8d%95%e5%85%8b%e9%9a%86%e6%8a%97%e4%bd%93hx008%e6%b3%a8%e5%b0%84%e6%b6%b2\/"},"modified":"2018-08-09T12:05:55","modified_gmt":"2018-08-09T04:05:55","slug":"%e3%80%90%e7%bf%b0%e4%b8%adpd-1%e6%8b%9b%e5%8b%9f2%e3%80%91%e9%87%8d%e7%bb%84%e4%ba%ba%e6%ba%90%e5%8c%96%e6%8a%97-pd-1-%e5%8d%95%e5%85%8b%e9%9a%86%e6%8a%97%e4%bd%93hx008%e6%b3%a8%e5%b0%84%e6%b6%b2","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/30107\/","title":{"rendered":"\u3010\u7ff0\u4e2dPD-1\u62db\u52df2\u3011\u91cd\u7ec4\u4eba\u6e90\u5316\u6297 PD-1 \u5355\u514b\u9686\u6297\u4f53HX008\u6ce8\u5c04\u6db2\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u7684\u591a\u4e2d\u5fc3\u3001\u5f00 \u653e\u3001II \u671f\u4e34\u5e8a\u7814\u7a76"},"content":{"rendered":"
\n
<\/mpcps><\/section>\n

1.  <\/span>\u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb<\/span>
<\/p>\n

\u6297<\/span>PD-1<\/span>\u6297\u4f53<\/span>(programmed death 1)<\/span>\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53<\/span>1<\/span>\uff0c\u662f\u4e00\u79cd\u91cd\u8981\u7684\u514d\u75ab\u6291\u5236\u5206\u5b50\u3002\u672c\u8bd5\u9a8c\u836f\u7269\u662f\u7ff0\u4e2d<\/span>\/<\/span>\u5eb7\u65b9\u751f\u7269\u533b\u836f\u7814\u53d1\u7684<\/span>HX008<\/span>\u3002<\/span><\/span><\/p>\n

\u672c\u8bd5\u9a8c\u7684\u9002\u5e94\u75c7\u662f\u7ecf\u4e00\u7ebf\u5316\u7597\u5931\u8d25\u540e\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u817a\u764c\u4ee5\u53ca\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u6216\u57fa\u56e0\u9519\u914d\u4fee\u590d\u7f3a\u9677\u665a\u671f\u5b9e\u4f53\u7624\u3002<\/span><\/p>\n

 <\/span><\/p>\n

2.      <\/span><\/span>\u8bd5\u9a8c\u76ee\u7684<\/span><\/span><\/p>\n

\u63a2\u7d22<\/span> HX008 <\/span>\u6ce8\u5c04\u6db2\u8054\u5408\u4f0a\u7acb\u66ff\u5eb7\u6cbb\u7597\u7ecf\u4e00\u7ebf\u5316\u7597\u5931\u8d25\u540e\u7684\u665a\u671f\u80c3\u817a\u764c\u7684\u6709\u6548\u6027\uff08\u5ba2\u89c2\u7f13\u89e3\u7387<\/span>ORR<\/span>\uff09\uff1b\u8bc4\u4f30\u91cd\u7ec4\u4eba\u6e90\u5316\u6297<\/span> PD-1 <\/span>\u5355\u514b\u9686\u6297\u4f53<\/span> HX008 <\/span>\u6ce8\u5c04\u6db2\u5355\u836f\u6cbb\u7597\u9ad8\u5ea6\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u578b<\/span>(MSI-H)<\/span>\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u578b<\/span>(dMMR)<\/span>\u665a\u671f\u5b9e\u4f53\u7624\u7684\u6709\u6548\u6027\uff08\u5ba2\u89c2\u7f13\u89e3\u7387<\/span>ORR<\/span>\uff09<\/span><\/span><\/p>\n

 <\/span><\/p>\n

3.       <\/span><\/span>\u8bd5\u9a8c\u8bbe\u8ba1<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u5206\u7c7b\uff1a<\/span>      <\/span>\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u5206\u671f\uff1a<\/span>      II<\/span>\u671f<\/span><\/span><\/p>\n

\u8bbe\u8ba1\u7c7b\u578b\uff1a<\/span>      <\/span>\u5355\u81c2\u8bd5\u9a8c<\/span><\/span><\/p>\n

\u968f\u673a\u5316\uff1a<\/span>          <\/span>\u975e\u968f\u673a\u5316<\/span><\/span><\/p>\n

\u76f2\u6cd5\uff1a<\/span>              <\/span>\u5f00\u653e<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u8303\u56f4\uff1a<\/span>      <\/span>\u56fd\u5185\u8bd5\u9a8c<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u4eba\u6570\uff1a<\/span>     123~138<\/span>\u4eba<\/span><\/span><\/p>\n

 <\/span><\/p>\n

4.       <\/span><\/span>\u5165\u9009\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u81ea\u613f\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\uff0c\u4e86\u89e3\u672c\u7814\u7a76\u5e76\u613f\u610f\u9075\u5faa\u800c\u4e14\u6709\u80fd\u529b\u5b8c\u6210\u6240\u6709\u8bd5\u9a8c\u7a0b\u5e8f<\/span><\/span><\/p>\n

2  <\/span>\u7537\u5973\u4e0d\u9650\uff0c\u5e74\u9f84<\/span> 18<\/span>\uff5e<\/span>70 <\/span>\u5c81\uff08\u542b\u8fb9\u754c\u503c\uff09<\/span><\/span><\/p>\n

3  <\/span>\u7f8e\u56fd\u4e1c\u90e8\u80bf\u7624\u534f\u4f5c\u7ec4\uff08<\/span>ECOG<\/span>\uff09\u8bc4\u5206\u4f53\u80fd\u72b6\u6001\u4e3a<\/span> 0 <\/span>\u6216<\/span> 1 <\/span>\u7684\u60a3\u8005<\/span><\/span><\/p>\n

4  <\/span>\u9884\u671f\u751f\u5b58\u81f3\u5c11<\/span> 3 <\/span>\u4e2a\u6708<\/span><\/span><\/p>\n

5  <\/span>\u6839\u636e\u5b9e\u4f53\u7624\u8bc4\u4ef7\u6807\u51c6\uff08<\/span>RECIST v1.1<\/span>\uff09\uff0c\u53d7\u8bd5\u8005\u987b\u6709\u53ef\u6d4b\u91cf\u75c5\u7076\uff08\u81f3\u5c11<\/span> 1 <\/span>\u4e2a\u9885\u5916\u75c5\u7076\uff09<\/span><\/span><\/p>\n

6  <\/span>\u65e0\u75c7\u72b6\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08<\/span>Central NervousSystem<\/span>\uff0c<\/span>CNS<\/span>\uff09\u8f6c\u79fb\uff0c\u6216\u7ecf\u8fc7\u6cbb\u7597\u65e0\u75c7\u72b6\u7684\u8111\u8f6c\u79fb\u60a3\u8005\uff0c\u987b\u7ecf\u8ba1\u7b97\u673a\u65ad\u5c42\u626b\u63cf\uff08<\/span>CT<\/span>\uff09\u6216\u6838\u78c1\u5171\u632f\u6210\u50cf\uff08<\/span>MRI<\/span>\uff09\u68c0\u67e5\u65e0\u75be\u75c5\u8fdb\u5c55\uff0c\u7a33\u5b9a\u81f3\u5c11<\/span> 3 <\/span>\u4e2a\u6708\uff0c\u5e76\u81f3\u5c11<\/span> 4 <\/span>\u5468\u5185\u65e0\u9700\u7c7b\u56fa\u9187\u836f\u7269\u6cbb\u7597<\/span><\/span><\/p>\n

7  <\/span>\u6709\u9002\u5b9c\u7684\u5668\u5b98\u53ca\u9020\u8840\u529f\u80fd\uff0c\u6839\u636e\u4ee5\u4e0b\u5b9e\u9a8c\u5ba4\u68c0\u67e5\uff1a\u55dc\u4e2d\u6027\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\uff08<\/span>ANC<\/span>\uff09\u2265<\/span>1.5<\/span>\u00d7<\/span>109 \/L<\/span>\uff1b\u767d\u7ec6\u80de\u7edd\u5bf9\u8ba1\u6570\uff08<\/span>WBC<\/span>\uff09\u2265<\/span>3.0<\/span>\u00d7<\/span>109 \/L<\/span>\uff1b\u8840\u5c0f\u677f\u2265<\/span>100<\/span>\u00d7<\/span>109 \/L<\/span>\uff1b\u8840\u7ea2\u86cb\u767d\u2265<\/span>90g\/L<\/span>\uff1b\u8840\u6e05\u808c\u9150\u2264<\/span>1.5 <\/span>\u500d\u6b63\u5e38\u503c\u4e0a\u9650\uff08<\/span>ULN<\/span>\uff09\uff1b<\/span> AST <\/span>\u548c<\/span> ALT<\/span>\u2264<\/span>2.5 <\/span>\u500d<\/span> ULN<\/span>\uff0c\u809d\u8f6c\u79fb\u60a3\u8005\u2264<\/span>5 <\/span>\u500d<\/span> ULN<\/span>\uff1b\u8840\u6e05\u603b\u80c6\u7ea2\u7d20\uff08<\/span>TBIL<\/span>\uff09\u2264<\/span>1.5 <\/span>\u500d<\/span> ULN<\/span>\uff1b\u56fd\u9645\u6807\u51c6\u5316\u6bd4\u7387\uff08<\/span>INR<\/span>\uff09\u2264<\/span>2 <\/span>\u500d<\/span> ULN<\/span>\uff0c\u6216\u6d3b\u5316\u90e8\u5206\u51dd\u8840\u6d3b\u9176\u65f6\uff08<\/span>APPT<\/span>\uff09\u2264<\/span>1.5 <\/span>\u500d<\/span> ULN<\/span>\uff08\u6b63\u5728\u63a5\u53d7\u6297\u51dd\u8840\u6cbb\u7597\u7684\u75c5\u4eba\u9664\u5916\uff09<\/span><\/span><\/p>\n

8  <\/span>\u7537\u6027\u53d7\u8bd5\u8005\u548c\u80b2\u9f84\u671f\u5973\u53d7\u8bd5\u8005\u5e94\u540c\u610f\u4ece\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\u5f00\u59cb\u76f4\u81f3\u6700\u540e\u4e00\u6b21\u7ed9\u836f\u540e<\/span> 3 <\/span>\u4e2a\u6708\u5185\u91c7\u53d6\u6709\u6548\u7684\u907f\u5b55\u63aa\u65bd<\/span><\/span><\/p>\n

9  <\/span>\u961f\u5217<\/span> 1 <\/span>\u7684\u5176\u4ed6\u7279\u6b8a\u5165\u7ec4\u6807\u51c6\uff1a<\/span> 1) <\/span>\u60a3\u6709\u7ecf\u7ec4\u7ec7\u5b66\u6216\u7ec6\u80de\u5b66\u786e\u8bca\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u80c3\u817a\u764c\uff08\u5305\u62ec\u80c3\u98df\u7ba1\u4ea4\u754c\u764c\uff09\uff1b<\/span> 2) <\/span>\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e00\u4e2a\u542b\u94c2\u65b9\u6848\u6216\u6c1f\u5c3f\u5627\u5576\u7c7b\u4e3a\u57fa\u7840\u65b9\u6848\u4e00\u7ebf\u5316\u7597\u5931\u8d25\u6216\u4e0d\u80fd\u8010\u53d7\u7684\u60a3\u8005\uff1b\u65b0\u8f85\u52a9<\/span>\/<\/span>\u8f85\u52a9\u6cbb\u7597\uff08\u5316\u7597\u6216\u653e\u7597\uff09\uff0c\u5982\u679c\u5728\u6cbb\u7597\u671f\u95f4\u6216\u505c\u6b62\u6cbb\u7597\u540e<\/span> 6 <\/span>\u4e2a\u6708\u5185\u75be\u75c5\u8fdb\u5c55\u8ba4\u4e3a\u662f\u4e00\u7ebf\u5316\u7597\u5931\u8d25\uff1b<\/span> 3) <\/span>\u8ddd\u79bb\u672b\u6b21\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u3001\u653e\u7597\u6216\u624b\u672f\u2265<\/span>4 <\/span>\u5468<\/span><\/span><\/p>\n

10  <\/span>\u961f\u5217<\/span> 2 <\/span>\u7684\u5176\u4ed6\u7279\u6b8a\u5165\u7ec4\u6807\u51c6\uff1a<\/span> 1) <\/span>\u7ecf\u7ec4\u7ec7\u5b66\u6216\u7ec6\u80de\u5b66\u786e\u8bca\u7684\u665a\u671f\u6076\u6027\u5b9e\u4f53\u7624\uff0c\u5e76\u7ecf\u7533\u529e\u65b9\u6307\u5b9a\u7684\u4e2d\u5fc3\u5b9e\u9a8c\u5ba4\u786e\u8ba4\u4e3a<\/span> MSI-H <\/span>\u6216<\/span> dMMR<\/span>\uff1b<\/span> 2) <\/span>\u60a3\u8005\u5fc5\u987b\u66fe\u7ecf\u63a5\u53d7\u6216\u4e0d\u8010\u53d7\u4e00\u7ebf\u6297\u80bf\u7624\u836f\u7269\u6cbb\u7597\u65b9\u6848\uff08\u5305\u62ec\u5316\u7597\u6216\u9776\u5411\u836f\u7269\u6cbb\u7597\uff09\uff1b\u5bf9\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u6839\u6cbb\u6027\u653e\u5316\u7597\uff0c\u8f85\u52a9\u6cbb\u7597\u6216\u65b0\u8f85\u52a9\u6cbb\u7597\uff0c\u82e5\u4e0a\u6b21\u6cbb\u7597\u5f00\u59cb<\/span><6 <\/span>\u4e2a\u6708\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\uff0c\u8be5\u6cbb\u7597\u65b9\u6848\u8ba4\u4e3a\u662f\u9488\u5bf9\u665a\u671f\u5b9e\u4f53\u7624\u7684\u4e00\u79cd\u6cbb\u7597\u65b9\u6848\uff1b<\/span><\/span><\/p>\n

 <\/span><\/p>\n

5.       <\/span><\/span>\u6392\u9664\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u5728\u5165\u7ec4\u524d<\/span> 5 <\/span>\u5e74\u5185\u7f79\u60a3\u5176\u4ed6\u6076\u6027\u80bf\u7624\u8005\uff0c\u9664\u5916\u5df2\u6cbb\u6108\u7684\u5bab\u9888\u539f\u4f4d\u764c\u3001\u75ca\u6108\u7684\u76ae\u80a4\u57fa\u5e95\u7ec6\u80de\u764c<\/span><\/span><\/p>\n

2  <\/span>\u4ee5\u5f80\u6cbb\u7597\u7684\u4e0d\u826f\u53cd\u5e94\u672a\u80fd\u6062\u590d\u81f3<\/span> CTCAE v5.0 <\/span>\u7b49\u7ea7\u8bc4\u5206\u2264<\/span>1 <\/span>\u7ea7\uff0c\u9664\u6b8b\u7559\u7684\u8131\u53d1\u6548\u5e94\u4e4b\u5916<\/span><\/span><\/p>\n

3  <\/span>\u66fe\u63a5\u53d7\u6297<\/span> PD-1<\/span>\u3001<\/span>PD-L1<\/span>\u3001<\/span>CTLA-4 <\/span>\u5355\u6297\u7b49\u6cbb\u7597\u7684\u60a3\u8005<\/span><\/span><\/p>\n

4  <\/span>\u60a3\u6709\u6d3b\u52a8\u6027\u3001\u6216\u6709\u75c5\u53f2\u4e14\u6709\u53ef\u80fd\u590d\u53d1\u7684\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u53d7\u8bd5\u8005\uff08\u5982\uff1a\u5168\u8eab\u6027\u7ea2\u6591\u72fc\u75ae\u3001\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u708e\u75c7\u6027\u80a0\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u6027\u7532\u72b6\u817a\u75be\u75c5\u3001\u591a\u53d1\u6027\u786c\u5316\uff0c\u8840\u7ba1\u708e\u3001\u80be\u5c0f\u7403\u708e\u7b49\uff09\uff0c\u6216\u9ad8\u98ce\u9669\uff08\u5982\u63a5\u53d7\u8fc7\u5668\u5b98\u79fb\u690d\u9700\u8981\u63a5\u53d7\u514d\u75ab\u6291\u5236\u6cbb\u7597\uff09\u7684\u60a3\u8005\u3002\u4f46\u5141\u8bb8\u60a3\u4ee5\u4e0b\u75be\u75c5\u7684\u53d7\u8bd5\u8005\u5165\u7ec4\uff1a\u91c7\u7528\u56fa\u5b9a\u5242\u91cf\u7684\u80f0\u5c9b\u7d20\u540e\u75c5\u60c5\u7a33\u5b9a\u7684<\/span> I <\/span>\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\uff1b\u53ea\u9700\u63a5\u53d7\u6fc0\u7d20\u66ff\u4ee3\u6cbb\u7597\u7684\u81ea\u8eab\u514d\u75ab\u6027\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\uff1b\u65e0\u9700\u8fdb\u884c\u5168\u8eab\u6cbb\u7597\u7684\u76ae\u80a4\u75be\u75c5\uff08\u5982\u6e7f\u75b9\uff0c\u5360\u4f53\u8868<\/span> 10%<\/span>\u4ee5\u4e0b\u7684\u76ae\u75b9\uff0c\u65e0\u773c\u79d1\u75c7\u72b6\u7684\u94f6\u5c51\u75c5\u7b49\uff09<\/span><\/span><\/p>\n

5  <\/span>\u9884\u671f\u5728\u672c\u7814\u7a76\u671f\u95f4\u5305\u62ec<\/span> 28 <\/span>\u5929\u7b5b\u9009\u671f\u6709\u91cd\u5927\u624b\u672f\u7684\u60a3\u8005<\/span><\/span><\/p>\n

6  <\/span>\u9996\u6b21\u7ed9\u836f\u524d<\/span> 14 <\/span>\u5929\u5185\u6216\u7814\u7a76\u671f\u95f4\u9700\u8981\u63a5\u53d7\u5168\u8eab\u7528\u76ae\u8d28\u7c7b\u56fa\u9187\uff08\u5242\u91cf\u76f8\u5f53\u4e8e<\/span>>10 mg <\/span>\u5f3a\u7684\u677e<\/span>\/<\/span>\u5929\uff09\u6216\u5176\u4ed6\u514d\u75ab\u6291\u5236\u836f\u7269\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\uff1b\u4ee5\u4e0b\u60c5\u51b5\u5141\u8bb8\u5165\u7ec4\uff1a\u5141\u8bb8\u53d7\u8bd5\u8005\u4f7f\u7528\u5c40\u90e8\u5916\u7528\u6216\u5438\u5165\u578b\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff1b\u5141\u8bb8\u77ed\u671f\uff08\u2264<\/span>7 <\/span>\u5929\uff09\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u8fdb\u884c\u9884\u9632\u6216\u6cbb\u7597\u975e\u81ea\u8eab\u514d\u75ab\u6027\u7684\u8fc7\u654f\u6027\u75be\u75c5<\/span><\/span><\/p>\n

7  <\/span>\u4f34\u6709\u6d3b\u52a8\u6027\u6d88\u5316\u9053\u6e83\u75a1\u3001\u4e0d\u5b8c\u5168\u6027\u80a0\u6897\u963b\u3001\u6d88\u5316\u9053\u6d3b\u52a8\u6027\u51fa\u8840\u3001\u7a7f\u5b54\u7684\u60a3\u8005<\/span><\/span><\/p>\n

8  <\/span>\u73b0\u60a3\u6709\u95f4\u8d28\u6027\u80ba\u75c5\u6216\u80ba\u708e\uff0c\u80ba\u7ea4\u7ef4\u5316\uff0c\u6025\u6027\u80ba\u90e8\u75be\u75c5\uff0c\u653e\u5c04\u6027\u80ba\u708e<\/span><\/span><\/p>\n

9  <\/span>\u7ecf\u6cbb\u7597\u672a\u63a7\u5236\u7a33\u5b9a\u7684\u7cfb\u7edf\u6027\u75be\u75c5\uff0c\u5982\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u538b\u80ba\u7ed3\u6838\u7b49<\/span><\/span><\/p>\n

10  <\/span>\u6709\u611f\u67d3\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\u75c5\u53f2\uff0c\u6216\u60a3\u6709\u5176\u4ed6\u83b7\u5f97\u6027\u3001\u5148\u5929\u6027\u514d\u75ab\u7f3a\u9677\u75be\u75c5\uff0c\u6216\u6709\u5668\u5b98\u79fb\u690d\u53f2\uff0c\u6216\u5e72\u7ec6\u80de\u79fb\u690d\u53f2<\/span><\/span><\/p>\n

11  <\/span>\u6162\u6027\u4e59\u578b\u809d\u708e\u6d3b\u52a8\u671f\u6216\u6d3b\u52a8\u6027\u4e19\u578b\u809d\u708e\u60a3\u8005\u3002\u4e59\u809d\u75c5\u6bd2\u643a\u5e26\u8005\u3001\u7ecf\u836f\u7269\u6cbb\u7597\u540e\u7a33\u5b9a\u7684\u4e59\u809d\uff08<\/span>DNA <\/span>\u6ef4\u5ea6\u4e0d\u5f97\u9ad8\u4e8e<\/span> 500 IU\/mL <\/span>\u6216\u62f7\u8d1d\u6570\uff1c<\/span> 1000copies\/ml<\/span>\uff09\u548c\u5df2\u6cbb\u6108\u7684\u4e19\u809d\u60a3\u8005\uff08<\/span>HCV RNA <\/span>\u68c0\u6d4b\u9634\u6027\uff09\u53ef\u4ee5\u5165\u7ec4<\/span><\/span><\/p>\n

12  <\/span>\u9996\u6b21\u7ed9\u836f\u524d<\/span> 4 <\/span>\u5468\u5185\u6709\u4e25\u91cd\u611f\u67d3\u8005\uff0c\u6216\u524d<\/span> 2 <\/span>\u5468\u5185\u51fa\u73b0\u6d3b\u52a8\u6027\u611f\u67d3\u9700\u8981\u53e3\u670d\u6216\u9759\u8109\u63a5\u53d7\u6297\u751f\u7d20\u6cbb\u7597\u7684\u60a3\u8005<\/span><\/span><\/p>\n

13  <\/span>\u5df2\u77e5\u53d7\u8bd5\u8005\u65e2\u5f80\u5bf9\u5927\u5206\u5b50\u86cb\u767d\u5236\u5242<\/span>\/<\/span>\u5355\u514b\u9686\u6297\u4f53\uff0c\u6216\u5df2\u77e5\u5bf9\u4efb\u4f55\u8bd5\u9a8c\u836f\u7269\u7ec4\u6210\u6210\u5206\u53d1\u751f\u4e25\u91cd\u8fc7\u654f\u53cd\u5e94\u8005\uff08<\/span>CTCAE v5.0 <\/span>\u5206\u7ea7\u5927\u4e8e<\/span> 3 <\/span>\u7ea7\uff09<\/span><\/span><\/p>\n

14  <\/span>\u9996\u6b21\u7ed9\u836f\u524d<\/span> 4 <\/span>\u5468\u5185\u53c2\u52a0\u8fc7\u5176\u4ed6\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\uff08\u4ee5\u4f7f\u7528\u8bd5\u9a8c\u836f\u7269\u4e3a\u51c6\uff09<\/span><\/span><\/p>\n

15  <\/span>\u9152\u7cbe\u4f9d\u8d56\u8005\u6216\u8fd1<\/span> 1 <\/span>\u5e74\u5185\u6709\u5438\u6bd2\u6216\u836f\u7269\u6ee5\u7528\u53f2<\/span><\/span><\/p>\n

16  <\/span>\u65e2\u5f80\u6709\u660e\u786e\u7684\u795e\u7ecf\u6216\u7cbe\u795e\u969c\u788d\u53f2\uff0c\u5982\u766b\u75eb\u3001\u75f4\u5446\uff0c\u4f9d\u4ece\u6027\u5dee\u8005\uff0c\u6216\u5b58\u5728\u5916\u5468\u795e\u7ecf\u7cfb\u7edf\u969c\u788d\u8005<\/span><\/span><\/p>\n

17  <\/span>\u6709\u75c7\u72b6\u7684\u8111\u8f6c\u79fb\u8005<\/span><\/span><\/p>\n

18  <\/span>\u598a\u5a20\u671f\u6216\u54fa\u4e73\u671f\u5973\u6027<\/span><\/span><\/p>\n

19  <\/span>\u7814\u7a76\u8005\u8ba4\u4e3a\u7531\u4e8e\u5176\u4ed6\u539f\u56e0\u4e0d\u9002\u5408\u53c2\u52a0\u8be5\u8bd5\u9a8c\u7684\u53d7\u8bd5\u8005<\/span> <\/span><\/span><\/p>\n


<\/p>\n

6.       <\/span><\/span>\u533b\u9662\u548c\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/span><\/p>\n\n\n\n\n\n
\n

\u59d3\u540d <\/span><\/p>\n<\/td>\n

\n

\u9ec4\u955c\uff0c\u535a\u58eb <\/span><\/p>\n<\/td>\n

\n

\u804c\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e3b\u4efb\u533b\u5e08 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u90ae\u653f\u5730\u5740 <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u5e02\u671d\u9633\u533a\u6f58\u5bb6\u56ed\u5357\u91cc17\u53f7 <\/span><\/p>\n<\/td>\n

\n

\u90ae\u7f16 <\/span><\/p>\n<\/td>\n

\n

100021 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5355\u4f4d\u540d\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/span><\/p>\n

\u672c\u8bd5\u9a8c\u4fe1\u606f\u6765\u81ea<\/span>CFDA<\/span>\u201c\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u4e0e\u516c\u793a\u5e73\u53f0\u201d\u3002<\/span><\/span><\/p>\n

\u6b22\u8fce\u7533\u529e\u65b9\/CRO\/\u533b\u9662\u63d0\u4f9b\u80bf\u7624\u62db\u52df\u4fe1\u606f\uff0c\u53ef\u4ee5\u53d1\u90ae\u4ef6\u81f3LCSYZMXX@163.com\uff0c\u672c\u516c\u4f17\u53f7\u514d\u8d39\u63a8\u9001\u3002<\/span><\/p>\n

\n


<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u4fe1\u606f <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

1.  \u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb \u6297PD-1\u6297\u4f53(programmed death 1)\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f531\uff0c\u662f\u4e00\u79cd […]<\/p>\n","protected":false},"author":1,"featured_media":30108,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30107"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=30107"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30107\/revisions"}],"predecessor-version":[{"id":30113,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30107\/revisions\/30113"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/30108"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=30107"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=30107"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=30107"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}