{"id":30114,"date":"2018-08-01T01:00:00","date_gmt":"2018-08-09T04:05:57","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e3%80%90%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%85%e3%80%91%e5%a5%a5%e5%8d%a1%e6%9b%bf%e5%b0%bc%e6%b2%bb%e7%96%97alk%e9%98%b3%e6%80%a7%e6%88%96ros1%e9%98%b3%e6%80%a7%e4%b8%94%e7%bb%8f%e4%b8%80%e7%ba%bf\/"},"modified":"2018-08-09T12:05:59","modified_gmt":"2018-08-09T04:05:59","slug":"%e3%80%90%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%85%e3%80%91%e5%a5%a5%e5%8d%a1%e6%9b%bf%e5%b0%bc%e6%b2%bb%e7%96%97alk%e9%98%b3%e6%80%a7%e6%88%96ros1%e9%98%b3%e6%80%a7%e4%b8%94%e7%bb%8f%e4%b8%80%e7%ba%bf","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/30114\/","title":{"rendered":"\u3010\u62db\u52df\u60a3\u8005\u3011\u5965\u5361\u66ff\u5c3c\u6cbb\u7597ALK\u9633\u6027\u6216ROS1\u9633\u6027\u4e14\u7ecf\u4e00\u7ebf\uff08\u5316\u7597\u6216\u514b\u5511\u66ff\u5c3c\uff09\u6cbb\u7597\u5931\u8d25\u7684\u665a\u671fNSCLC\u60a3\u8005\u7684\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c"},"content":{"rendered":"
\n

1.      <\/span><\/span>\u836f\u7269\u7b80\u4ecb<\/span><\/span><\/p>\n

\u672c\u8bd5\u9a8c\u7684\u9002\u5e94\u75c7\u662f<\/span>\u590d\u6cbb<\/span>ALK\/ROS1<\/span>\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/span><\/span><\/p>\n

 <\/span><\/p>\n

2.  <\/span>\u8bd5\u9a8c\u76ee\u7684<\/span><\/p>\n

\u63a2\u7d22\u5965\u5361\u66ff\u5c3c\uff08\u4ee3\u53f7<\/span>ZG0418<\/span>\uff09\u6cbb\u7597<\/span>ALK<\/span>\u9633\u6027\u6216<\/span>ROS1<\/span>\u9633\u6027\u4e14\u7ecf\u4e00\u7ebf\uff08\u5316\u7597\u6216\u514b\u5511\u66ff\u5c3c\uff09\u6cbb\u7597\u5931\u8d25\u7684\u665a\u671f<\/span>NSCLC<\/span>\u60a3\u8005\u4e2d\u7684\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08<\/span>DLT<\/span>\uff09\uff0c\u5e76\u786e\u5b9a\u6700\u5927\u8010\u53d7\u5242\u91cf\uff08<\/span>MTD<\/span>\uff09\u6216<\/span>II<\/span>\u671f\u7814\u7a76\u63a8\u8350\u5242\u91cf\uff08<\/span>R2PD<\/span>\uff09\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

3.  <\/span>\u8bd5\u9a8c\u8bbe\u8ba1<\/span><\/p>\n

\u8bd5\u9a8c\u5206\u7c7b\uff1a   \u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/span><\/p>\n

\u8bd5\u9a8c\u5206\u671f\uff1a   I\u671f<\/span><\/p>\n

\u8bbe\u8ba1\u7c7b\u578b\uff1a   \u5355\u81c2\u8bd5\u9a8c<\/span><\/p>\n

\u968f\u673a\u5316\uff1a     \u975e\u968f\u673a\u5316<\/span><\/p>\n

\u76f2\u6cd5\uff1a       \u5f00\u653e<\/span><\/p>\n

\u8bd5\u9a8c\u8303\u56f4\uff1a   \u56fd\u5185\u8bd5\u9a8c<\/span><\/p>\n

\u8bd5\u9a8c\u4eba\u6570\uff1a   9-30<\/span><\/p>\n

 <\/span><\/p>\n

4.  <\/span>\u5165\u9009\u6807\u51c6<\/span><\/p>\n

1  \u65e2\u5f80\u63a5\u53d7\u514b\u5511\u66ff\u5c3c\u6216\u5176\u4ed6\u4e00\u7ebf\u6cbb\u7597\u5931\u8d25\u7684ALK\u9633\u6027\u6216ROS1\u9633\u6027\u665a\u671fNSCLC\u60a3\u8005\u3002\u60a3\u8005\u9700\u6709ALK\u9633\u6027\u6216ROS1\u9633\u6027\u7684\u75c5\u7406\u6027\u8bca\u65ad\u8bc1\u636e\uff08\u53ef\u63d0\u4f9b\u4ee5\u4e0b\u4e09\u79cd\u68c0\u6d4b\u7ed3\u679c\u4e4b\u4e00\u5373\u53ef\uff1a\u2460\u8367\u5149\u539f\u4f4d\u6742\u4ea4\uff08fluorescentin situ hybridization, FISH\uff09\uff1b\u2461\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u6cd5\uff08IHC\uff09\uff08\u5bf9ALK\u7684\u68c0\u6d4b\u5fc5\u987b\u662fVentana-IHC\u68c0\u6d4b\uff09\uff1b\u2462RT-PCR\uff09\uff1b<\/span><\/p>\n

2  \u9884\u671f\u751f\u5b58\u671f\u5927\u4e8e12\u5468<\/span><\/p>\n

3  ECOG\u8bc4\u52060-2 <\/span><\/p>\n

4  \u6839\u636eRECIST 1.1\u6807\u51c6\uff0c\u81f3\u5c11\u6709\u4e00\u4e2a\u53ef\u8bc4\u4f30\u7684\u75c5\u7076<\/span><\/p>\n

5  \u5408\u5e76\u8111\u8f6c\u79fb\u7684NSCLC\u60a3\u8005\uff0c\u9700\u540c\u65f6\u6ee1\u8db3\uff1a\u2460CNS\u75c7\u72b6\u7a33\u5b9a\uff1b\u2461\u7b5b\u9009\u524d2\u5468\u5185\u672a\u589e\u52a0\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5242\u91cf\u7528\u4ee5\u63a7\u5236CNS\u75c7\u72b6<\/span><\/p>\n

6  \u6709\u751f\u80b2\u80fd\u529b\u7684\u60a3\u8005\uff0c\u9700\u5728\u7814\u7a76\u671f\u95f4\u76f4\u81f3\u6cbb\u7597\u7ed3\u675f\u540e3\u4e2a\u6708\u5185\u91c7\u53d6\u9ad8\u6548\u907f\u5b55\u63aa\u65bd\u3002\u5176\u4e2d\uff0c\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\uff0c\u9700\u5728\u9996\u6b21\u7528\u836f\u524d2\u5468\u5185\u7684\u68c0\u6d4b\u8840HCG\u5e76\u5448\u9634\u6027\uff1b<\/span><\/p>\n

7  \u81ea\u613f\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\uff1b<\/span><\/p>\n

8  \u5e74\u9f84 18 -75\u5468\u5c81\uff0c\u7537\u5973\u4e0d\u9650\uff1b<\/span><\/p>\n

 <\/span><\/p>\n

5.  <\/span>\u6392\u9664\u6807\u51c6<\/span><\/p>\n

1  \u65e2\u5f80\u6709\u80ba\u95f4\u8d28\u7ea4\u7ef4\u5316\u6216\u95f4\u8d28\u6027\u80ba\u75c5\uff0c\u5305\u62ec\u95f4\u8d28\u6027\u80ba\u708e\u3001\u8fc7\u654f\u6027\u80ba\u708e\u3001\u95ed\u585e\u6027\u7ec6\u652f\u6c14\u7ba1\u708e\uff1b<\/span><\/p>\n

2  \u77e5\u60c5\u540c\u610f\u524d4\u5468\u5185\u63a5\u53d7\u8fc7\u6297\u80bf\u7624\u6cbb\u7597\uff08\u5305\u62ec\u5316\u7597\u3001\u653e\u7597\u3001PD-1\/PD-L1\u6291\u5236\u5242\u7b49\u6cbb\u7597\uff09\u6216\u7528\u836f\u524d4\u5468\u5185\u53c2\u52a0\u5176\u5b83\u4e34\u5e8a\u8bd5\u9a8c\u8005\u3002<\/span><\/p>\n

3  \u60a3\u6709\u6d3b\u52a8\u6027\u6d88\u5316\u6027\u6e83\u75a1\u3001\u660e\u663e\u5455\u5410\u3001\u6162\u6027\u8179\u6cfb\u3001\u80a0\u6897\u963b\u3001\u5438\u6536\u969c\u788d\u7b49\u6216\u5176\u4ed6\u5df2\u77e5\u4f1a\u5f71\u54cd\u836f\u7269\u5438\u6536\u7684\u75be\u75c5\uff1b<\/span><\/p>\n

4  \u4ee5\u4e0b\u4efb\u4f55\u663e\u8457\u7684\u4e34\u5e8a\u548c\u5b9e\u9a8c\u5ba4\u5f02\u5e38\uff0c\u7814\u7a76\u8005\u8ba4\u4e3a\u5f71\u54cd\u5b89\u5168\u6027\u8bc4\u4ef7\u8005\uff0c\u5982\uff1a\u2460\u836f\u7269\u4e0d\u80fd\u63a7\u5236\u7684\u9ad8\u8840\u538b\uff08\u6536\u7f29\u538b\u2265150 mmHg\u548c\/\u6216\u8212\u5f20\u538b>90mmHg\uff09\uff1b\u2461\u9700\u8981\u7528\u836f\u7269\u63a7\u5236\u7684\u5ba4\u6027\u5fc3\u5f8b\u5931\u5e38\u3001\u5ba4\u4e0a\u6027\u5fc3\u5f8b\u5931\u5e38\u6216\u7ed3\u6027\u5fc3\u5f8b\u5931\u5e38\uff1b\u2462QTc\u95f4\u671f\uff08QTcB\uff09>480ms\u7684\u60a3\u8005\uff1b\u2463\u7b5b\u9009\u524d6\u4e2a\u6708\u5185\u6709III\u7ea7\u6216\u4ee5\u4e0a\u5145\u8840\u6027\u5fc3\u529b\u8870\u7aed\uff08NCI-CTCAE v4.03\uff09\u3001\u65e0\u6cd5\u63a7\u5236\u6216\u5c1a\u4e0d\u7a33\u5b9a\u7684\u5fc3\u7ede\u75db\u6216\u5fc3\u808c\u6897\u585e\u60a3\u8005\u3002<\/span><\/p>\n

5  \u5408\u5e76\u5176\u5b83\u4e25\u91cd\u75be\u75c5\u8005\uff0c\u5982\u6d3b\u52a8\u6027\u6216\u672a\u63a7\u5236\u7684\u611f\u67d3\uff08\u7ed3\u6838\u3001HIV\uff09\uff0c\u5931\u4ee3\u507f\u6027\u809d\u75c5\uff0c\u6d3b\u52a8\u6027\u809d\u708e\uff0c\u6d3b\u52a8\u6027\u51fa\u8840\uff1b\u8111\u8840\u7ba1\u610f\u5916\u4e8b\u4ef6\u6216\u80ba\u6813\u585e\u60a3\u8005\uff1b<\/span><\/p>\n

6  \u6ca1\u6709\u80fd\u529b\u541e\u54bd\u8bd5\u9a8c\u836f\u7269\u3002<\/span><\/p>\n

 <\/span><\/p>\n

6.  <\/span>\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/p>\n\n\n\n\n\n
\n

\u59d3\u540d <\/span><\/p>\n<\/td>\n

\n

\u674e\u8fdb,\u535a\u58eb <\/span><\/p>\n<\/td>\n

\n

\u804c\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u6559\u6388 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u90ae\u653f\u5730\u5740 <\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77\u5e02\u6d66\u4e1c\u65b0\u533a\u4e91\u53f0\u8def1800\u53f7 <\/span><\/p>\n<\/td>\n

\n

\u90ae\u7f16 <\/span><\/p>\n<\/td>\n

\n

200123 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5355\u4f4d\u540d\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e0a\u6d77\u5e02\u4e1c\u65b9\u533b\u9662 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/span><\/p>\n

\u672c\u8bd5\u9a8c\u4fe1\u606f\u6765\u81ea<\/span>CFDA<\/span>\u201c\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u4e0e\u516c\u793a\u5e73\u53f0\u201d\u3002<\/span><\/span><\/p>\n

\u6b22\u8fce\u7533\u529e\u65b9\/CRO\/\u533b\u9662\u63d0\u4f9b\u80bf\u7624\u62db\u52df\u4fe1\u606f\uff0c\u53ef\u4ee5\u53d1\u90ae\u4ef6\u81f3LCSYZMXX@163.com\uff0c\u672c\u516c\u4f17\u53f7\u9996\u6b21\u514d\u8d39\u63a8\u9001\uff08\u6765\u81ea\u201c<\/span>CFDA<\/span>\u201c\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u4e0e\u516c\u793a\u5e73\u53f0\u201d\u201d\uff09\uff0c\u5176\u4ed6\u5546\u4e1a\u5408\u4f5c\u4e5f\u53ef\u4ee5\u53d1\u6b64\u90ae\u7bb1\uff01<\/span><\/span><\/p>\n

\n


<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u4fe1\u606f <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

1.      \u836f\u7269\u7b80\u4ecb \u672c\u8bd5\u9a8c\u7684\u9002\u5e94\u75c7\u662f\u590d\u6cbbAL […]<\/p>\n","protected":false},"author":1,"featured_media":30115,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30114"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=30114"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30114\/revisions"}],"predecessor-version":[{"id":30120,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30114\/revisions\/30120"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/30115"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=30114"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=30114"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=30114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}