{"id":30121,"date":"2018-07-31T01:00:00","date_gmt":"2018-08-09T04:06:02","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e3%80%90%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%85%e3%80%91%e8%af%84%e4%bb%b7rc48-adc%e6%b2%bb%e7%96%97her2%e8%bf%87%e8%a1%a8%e8%be%be%e5%b1%80%e9%83%a8%e6%99%9a%e6%9c%9f%e6%88%96%e8%bd%ac%e7%a7%bb\/"},"modified":"2018-08-09T12:06:04","modified_gmt":"2018-08-09T04:06:04","slug":"%e3%80%90%e6%8b%9b%e5%8b%9f%e6%82%a3%e8%80%85%e3%80%91%e8%af%84%e4%bb%b7rc48-adc%e6%b2%bb%e7%96%97her2%e8%bf%87%e8%a1%a8%e8%be%be%e5%b1%80%e9%83%a8%e6%99%9a%e6%9c%9f%e6%88%96%e8%bd%ac%e7%a7%bb","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/30121\/","title":{"rendered":"\u3010\u62db\u52df\u60a3\u8005\u3011\u8bc4\u4ef7RC48-ADC\u6cbb\u7597HER2\u8fc7\u8868\u8fbe\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u764c\u60a3\u8005\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u5355\u81c2\u3001\u5f00\u653e\u3001\u591a\u4e2d\u5fc3II\u671f\u4e34\u5e8a\u7814\u7a76"},"content":{"rendered":"
\n
<\/mpcps><\/section>\n

<\/span><\/span>
<\/p>\n

1.       <\/span><\/span>\u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb<\/span><\/span><\/p>\n

RC48-ADC<\/span>\u662f\u91cd\u7ec4\u4eba\u6e90\u5316\u6297<\/span>HER2<\/span>\u5355\u6297<\/span>-MMAE<\/span>\u5076\u8054\u5242\u3002<\/span><\/span><\/p>\n

\u672c\u8bd5\u9a8c\u7684\u9002\u5e94\u75c7\u662f<\/span>HER2<\/span>\u8fc7\u8868\u8fbe\u80c3\u764c<\/span>\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

2.       <\/span><\/span>\u8bd5\u9a8c\u76ee\u7684<\/span><\/span><\/p>\n

\u8bc4\u4ef7<\/span>RC48-ADC<\/span>\u6cbb\u7597<\/span>HER2<\/span>\u8fc7\u8868\u8fbe\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u764c\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027<\/span><\/span><\/p>\n

 <\/span><\/p>\n

3.       <\/span><\/span>\u8bd5\u9a8c\u8bbe\u8ba1<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u5206\u7c7b\uff1a\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/span><\/p>\n

\u8bd5\u9a8c\u5206\u671f\uff1a<\/span> II<\/span>\u671f<\/span><\/span><\/p>\n

\u8bbe\u8ba1\u7c7b\u578b\uff1a\u5355\u81c2\u8bd5\u9a8c<\/span><\/p>\n

\u968f\u673a\u5316\uff1a<\/span>   <\/span>\u975e\u968f\u673a\u5316<\/span><\/span><\/p>\n

\u76f2\u6cd5\uff1a<\/span>        <\/span>\u5f00\u653e<\/span><\/span><\/p>\n

\u8bd5\u9a8c\u8303\u56f4\uff1a\u56fd\u5185\u8bd5\u9a8c<\/span> <\/span><\/span><\/p>\n

\u8bd5\u9a8c\u4eba\u6570\uff1a<\/span> 72<\/span><\/span>\u4eba<\/span><\/span><\/p>\n

 <\/span><\/p>\n

4.       <\/span><\/span>\u5165\u9009\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u81ea\u613f\u540c\u610f\u53c2\u4e0e\u7814\u7a76\u5e76\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\uff1b<\/span><\/span><\/p>\n

2  <\/span>\u5e74\u9f84<\/span>18-70<\/span>\u5c81\uff08\u5305\u62ec<\/span>18<\/span>\u5c81\u548c<\/span>70<\/span>\u5c81\uff09\uff1b<\/span><\/span><\/p>\n

3  <\/span>\u9884\u671f\u751f\u5b58\u671f\u2265<\/span>12<\/span>\u5468\uff1b<\/span><\/span><\/p>\n

4  ECOG <\/span>\u4f53\u529b\u72b6\u51b5<\/span>0<\/span>\u6216<\/span>1<\/span>\u5206\uff1b<\/span><\/span><\/p>\n

5  <\/span>\u5bf9\u4e8e\u5973\u6027\u53d7\u8bd5\u8005\uff1a\u5e94\u4e3a\u624b\u672f\u7edd\u80b2\u3001\u7edd\u7ecf\u540e\u7684\u60a3\u8005\uff0c\u6216\u540c\u610f\u5728\u7814\u7a76\u6cbb\u7597\u671f\u95f4\u548c\u7814\u7a76\u6cbb\u7597\u671f\u7ed3\u675f\u540e<\/span>6<\/span>\u4e2a\u6708\u5185\u91c7\u7528\u4e00\u79cd\u7ecf\u533b\u5b66\u8ba4\u53ef\u7684\u907f\u5b55\u63aa\u65bd\uff08\u5982\u5bab\u5185\u8282\u80b2\u5668\u3001\u907f\u5b55\u836f\u6216\u907f\u5b55\u5957\uff09\uff1b\u5728\u7814\u7a76\u7ed9\u836f\u524d\u7684<\/span>7<\/span>\u5929\u5185\u8840\u598a\u5a20\u8bd5\u9a8c\u5fc5\u987b\u4e3a\u9634\u6027\uff0c\u4e14\u5fc5\u987b\u4e3a\u975e\u54fa\u4e73\u671f\u3002\u5bf9\u4e8e\u7537\u6027\u53d7\u8bd5\u8005\uff1a\u5e94\u4e3a\u624b\u672f\u7edd\u80b2\uff0c\u6216\u540c\u610f\u5728\u7814\u7a76\u6cbb\u7597\u671f\u95f4\u548c\u7814\u7a76\u6cbb\u7597\u671f\u7ed3\u675f\u540e<\/span>6<\/span>\u4e2a\u6708\u5185\u91c7\u7528\u4e00\u79cd\u7ecf\u533b\u5b66\u8ba4\u53ef\u7684\u907f\u5b55\u63aa\u65bd\uff1b<\/span><\/span><\/p>\n

6  <\/span>\u80fd\u591f\u7406\u89e3\u8bd5\u9a8c\u8981\u6c42\uff0c\u613f\u610f\u4e14\u80fd\u591f\u9075\u4ece\u8bd5\u9a8c\u548c\u968f\u8bbf\u7a0b\u5e8f\u5b89\u6392\u3002<\/span><\/span><\/p>\n

7  <\/span>\u8db3\u591f\u7684\u5668\u5b98\u529f\u80fd<\/span><\/span><\/p>\n

8  <\/span>\u7ecf\u7ec4\u7ec7\u5b66\u548c<\/span>\/<\/span>\u6216\u7ec6\u80de\u5b66\u786e\u8bca\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u764c\uff08\u5305\u62ec\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\uff09\uff0c\u4e14\u65e0\u6cd5\u6cbb\u6108\u3001\u4e0d\u53ef\u5207\u9664\uff1b<\/span><\/span><\/p>\n

9  HER2 <\/span>\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\uff08<\/span>IHC<\/span>\uff09\u68c0\u67e5\u7ed3\u679c\u4e3a<\/span>IHC 2+<\/span>\u6216<\/span>IHC 3+ <\/span><\/span><\/p>\n

10  <\/span>\u80bf\u7624\u590d\u53d1<\/span>\/<\/span>\u8f6c\u79fb\u540e\u63a5\u53d7\u8fc7\u81f3\u5c11<\/span>2<\/span>\u4e2a\u5316\u7597\u65b9\u6848\u7cfb\u7edf\u6cbb\u7597<\/span><\/span><\/p>\n

11  <\/span>\u6839\u636e<\/span>RECIST 1.1<\/span>\u6807\u51c6\uff0c\u81f3\u5c11\u6709\u4e00\u4e2a\u53ef\u6d4b\u91cf\u75c5\u7076\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

5.       <\/span><\/span>\u6392\u9664\u6807\u51c6<\/span><\/span><\/p>\n

1  <\/span>\u7814\u7a76\u7ed9\u836f\u5f00\u59cb\u524d<\/span>4<\/span>\u5468\u5185\u4f7f\u7528\u4e34\u5e8a\u7814\u7a76\u6027\u836f\u7269\uff1b<\/span><\/span><\/p>\n

2  <\/span>\u7814\u7a76\u7ed9\u836f\u5f00\u59cb\u524d<\/span>4<\/span>\u5468\u5185\u8fdb\u884c\u8fc7\u5927\u578b\u624b\u672f\u4e14\u672a\u5b8c\u5168\u6062\u590d\uff1b<\/span><\/span><\/p>\n

3  <\/span>\u7814\u7a76\u7ed9\u836f\u5f00\u59cb\u524d<\/span>4<\/span>\u5468\u5185\u63a5\u79cd\u8fc7\u6d3b\u75ab\u82d7\u6216\u8ba1\u5212\u5728\u7814\u7a76\u671f\u95f4\u63a5\u53d7\u4efb\u4f55\u75ab\u82d7\uff1b<\/span><\/span><\/p>\n

4  <\/span>\u7814\u7a76\u7ed9\u836f\u524d<\/span>1<\/span>\u5e74\u5185\u53d1\u751f\u8fc7\u4e25\u91cd\u52a8<\/span>\/<\/span>\u9759\u8109\u8840\u6813\u4e8b\u4ef6\uff0c\u5982\u8111\u8840\u7ba1\u610f\u5916\uff08\u5305\u62ec\u6682\u65f6\u6027\u7f3a\u8840\u6027\u53d1\u4f5c\uff09\u3001\u6df1\u9759\u8109\u8840\u6813\u3001\u80ba\u6813\u585e\u3001\u5fc3\u808c\u6897\u6b7b\u7b49\uff1b<\/span><\/span><\/p>\n

5  <\/span>\u6b63\u60a3\u6709\u672a\u7ecf\u7a33\u5b9a\u63a7\u5236\u7684\u7cfb\u7edf\u6027\u75be\u75c5\uff0c\u5305\u62ec\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u538b\u3001\u80ba\u7ea4\u7ef4\u5316\u3001\u6025\u6027\u80ba\u90e8\u75be\u75c5\u3001\u95f4\u8d28\u6027\u80ba\u75c5\u3001\u809d\u786c\u5316\u3001\u5fc3\u7ede\u75db\u3001\u4e25\u91cd\u5fc3\u5f8b\u5931\u5e38\u7b49\uff1b<\/span><\/span><\/p>\n

6  <\/span>\u5b58\u5728\u8111\u8f6c\u79fb\u548c<\/span>\/<\/span>\u6216\u764c\u6027\u8111\u819c\u708e\uff1b<\/span><\/span><\/p>\n

7  <\/span>\u7b7e\u7f72\u77e5\u60c5\u540c\u610f\u4e66\u524d<\/span>5<\/span>\u5e74\u5185\u60a3\u6709\u5176\u4ed6\u6076\u6027\u80bf\u7624\uff08\u5df2\u7ecf\u6709\u6548\u6cbb\u7597\u7684\u975e\u9ed1\u8272\u7d20\u7624\u6027\u76ae\u80a4\u764c\u3001\u5bab\u9888\u539f\u4f4d\u764c\u3001\u5bfc\u7ba1\u539f\u4f4d\u764c\u6216\u5176\u4ed6\u80bf\u7624\uff0c\u88ab\u8ba4\u4e3a\u5df2\u7ecf\u6cbb\u6108\u7684\u6076\u6027\u80bf\u7624\u9664\u5916\uff09\uff1b<\/span><\/span><\/p>\n

8  <\/span>\u65e2\u5f80\u6297\u80bf\u7624\u6cbb\u7597\u7684\u6bd2\u6027\u53cd\u5e94\u5c1a\u672a\u6062\u590d\u5230<\/span>CTCAE [4.03<\/span>\u7248<\/span>] 0-1<\/span>\u7ea7\uff0c\u4ee5\u4e0b\u60c5\u51b5\u9664\u5916\uff1a<\/span>a.<\/span>\u8131\u53d1\uff1b<\/span>b. <\/span>\u8272\u7d20\u6c89\u7740\uff1b<\/span>c. <\/span>\u653e\u7597\u5f15\u8d77\u7684\u8fdc\u671f\u6bd2\u6027\uff0c\u7ecf\u7814\u7a76\u8005\u5224\u65ad\u4e0d\u80fd\u6062\u590d\uff1b<\/span><\/span><\/p>\n

9  <\/span>\u65e2\u5f80\u63a5\u53d7<\/span>T-DM1<\/span>\u6cbb\u7597\u6216\u53c2\u52a0\u8fc7\u8be5\u7c7b\u836f\u7269\u7684\u4e34\u5e8a\u7814\u7a76\u3002<\/span><\/span><\/p>\n

10  <\/span>\u4f34\u6709\u4e34\u5e8a\u75c7\u72b6\u6216\u9700\u8981\u5bf9\u75c7\u5904\u7406\u7684\u5927\u91cf\u80f8\u6c34\u6216\u8179\u6c34\uff1b<\/span><\/span><\/p>\n

11  <\/span>\u60a3\u6709\u4efb\u4f55\u5176\u5b83\u75be\u75c5\uff0c\u4ee3\u8c22\u5f02\u5e38\uff0c\u4f53\u683c\u68c0\u67e5\u5f02\u5e38\u6216\u5b9e\u9a8c\u5ba4\u68c0\u67e5\u5f02\u5e38\uff0c\u6839\u636e\u7814\u7a76\u8005\u5224\u65ad\uff0c\u6709\u7406\u7531\u6000\u7591\u60a3\u8005\u5177\u6709\u4e0d\u9002\u5408\u4f7f\u7528\u7814\u7a76\u836f\u7269\u7684\u67d0\u79cd\u75be\u75c5\u6216\u72b6\u6001\uff0c\u6216\u8005\u5c06\u4f1a\u5f71\u54cd\u7814\u7a76\u7ed3\u679c\u7684\u89e3\u8bfb\uff0c\u6216\u8005\u4f7f\u60a3\u8005\u5904\u4e8e\u9ad8\u98ce\u9669\u7684\u60c5\u51b5\uff1b<\/span><\/span><\/p>\n

 <\/span><\/p>\n

6.       <\/span><\/span>\u7814\u7a76\u8005\u4fe1\u606f<\/span><\/span><\/p>\n\n\n\n\n\n
\n

\u5e8f\u53f7 <\/span><\/p>\n<\/td>\n

\n

\u673a\u6784\u540d\u79f0 <\/span><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u7814\u7a76\u8005 <\/span><\/p>\n<\/td>\n

\n

\u56fd\u5bb6 <\/span><\/p>\n<\/td>\n

\n

\u7701\uff08\u5dde\uff09 <\/span><\/p>\n<\/td>\n

\n

\u57ce\u5e02 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1 <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u6c88\u7433 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac <\/span><\/p>\n<\/td>\n

\n

\u5317\u4eac <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

2 <\/span><\/p>\n<\/td>\n

\n

\u5929\u6d25\u5e02\u80bf\u7624\u533b\u9662 <\/span><\/p>\n<\/td>\n

\n

\u5df4\u4e00 <\/span><\/p>\n<\/td>\n

\n

\u4e2d\u56fd <\/span><\/p>\n<\/td>\n

\n

\u5929\u6d25 <\/span><\/p>\n<\/td>\n

\n

\u5929\u6d25 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/span><\/p>\n

\u672c\u8bd5\u9a8c\u4fe1\u606f\u6765\u81ea<\/span>CFDA<\/span>\u201c\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u4e0e\u516c\u793a\u5e73\u53f0\u201d\u3002<\/span><\/span><\/p>\n

\u6b22\u8fce\u7533\u529e\u65b9\/CRO\/\u533b\u9662\u63d0\u4f9b\u80bf\u7624\u62db\u52df\u4fe1\u606f\uff0c\u53ef\u4ee5\u53d1\u90ae\u4ef6\u81f3LCSYZMXX@163.com\uff0c\u672c\u516c\u4f17\u53f7\u9996\u6b21\u514d\u8d39\u63a8\u9001\uff08\u6765\u81ea<\/span>CFDA<\/span>\u201c\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u4e0e\u516c\u793a\u5e73\u53f0\u201d\uff09\uff0c\u5176\u4ed6\u5546\u4e1a\u5408\u4f5c\u4e5f\u53ef\u4ee5\u53d1\u6b64\u90ae\u7bb1\uff01<\/span><\/span><\/p>\n

\n

\n


<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u4e34\u5e8a\u8bd5\u9a8c\u62db\u52df\u4fe1\u606f <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

1.       \u8bd5\u9a8c\u836f\u7269\u7b80\u4ecb RC48-ADC\u662f […]<\/p>\n","protected":false},"author":1,"featured_media":30122,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30121"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=30121"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30121\/revisions"}],"predecessor-version":[{"id":30127,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30121\/revisions\/30127"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/30122"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=30121"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=30121"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=30121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}