{"id":30164,"date":"2018-08-07T01:00:00","date_gmt":"2018-08-09T04:06:23","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e5%90%89%e5%88%a9%e5%be%b74%e5%90%881%e8%89%be%e6%bb%8b%e7%97%85%e6%96%b0%e8%8d%afgenvoya%e5%9c%a8%e4%b8%ad%e5%9b%bd%e8%8e%b7%e6%89%b9%e4%b8%8a%e5%b8%82\/"},"modified":"2018-08-09T12:06:24","modified_gmt":"2018-08-09T04:06:24","slug":"%e5%90%89%e5%88%a9%e5%be%b74%e5%90%881%e8%89%be%e6%bb%8b%e7%97%85%e6%96%b0%e8%8d%afgenvoya%e5%9c%a8%e4%b8%ad%e5%9b%bd%e8%8e%b7%e6%89%b9%e4%b8%8a%e5%b8%82","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/30164\/","title":{"rendered":"\u5409\u5229\u5fb74\u54081\u827e\u6ecb\u75c5\u65b0\u836fGenvoya\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02"},"content":{"rendered":"
\n

\u5409\u5229\u5fb7\u79d1\u5b66\u516c\u53f88\u67086\u65e5\u5ba3\u5e03\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6Genvoya\uff08\u827e\u8003\u6069\u4e19\u66ff\u7247\uff0c\u5373E\/C\/F\/TAF\uff0c\u4e2d\u6587\u5546\u54c1\u540d\u6377\u6276\u5eb7\uff09\u7528\u4e8e\u6cbb\u7597HIV-1\u611f\u67d3\u3002Genvoya\u662f\u4e2d\u56fd\u9996\u4e2a\u6279\u51c6\u7684\u57fa\u4e8eTAF\/FTC\u3001\u7528\u4e8e\u6cbb\u7597HIV\u7684\u5355\u4e00\u7247\u5242\uff08STR\uff09\u65b9\u6848<\/strong>\u3002<\/span><\/p>\n


<\/strong><\/span><\/p>\n

\"\u5409\u5229\u5fb74\u54081\u827e\u6ecb\u75c5\u65b0\u836fGenvoya\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\"<\/p>\n


<\/p>\n

\u5728\u4e2d\u56fd\uff0cGenvoya\u662f\u53ef\u7528\u4e8e\u6cbb\u7597\u611f\u67d3HIV-1\u7684\u6210\u5e74\u548c\u9752\u5c11\u5e74\uff0812\u5c81\u4ee5\u4e0a\uff0c\u4f53\u91cd\u8d85\u8fc735\u516c\u65a4\uff09\u7684\u5b8c\u6574\u65b9\u6848\uff0c\u6ca1\u6709\u51fa\u73b0\u5bf9\u6574\u5408\u9176\u6291\u5236\u5242\u7c7b\u836f\u7269\u3001\u6069\u66f2\u4ed6\u6ee8\u6216\u66ff\u8bfa\u798f\u97e6\u8010\u836f\u76f8\u5173\u7684\u5df2\u77e5\u7a81\u53d8\u3002<\/span><\/p>\n


<\/p>\n

\u201c\u901a\u8fc7\u63a5\u53d7\u6070\u5f53\u7684\u6cbb\u7597\uff0cHIV\u611f\u67d3\u8005\u7684\u5bff\u547d\u53ef\u8fbe\u5230\u4e0e\u666e\u901a\u4eba\u7fa4\u76f8\u8fd1\u7684\u6c34\u5e73\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u60a3\u8005\u4e5f\u5c06\u9762\u4e34\u66f4\u591a\u4e0e\u5e74\u9f84\u548c\u6cbb\u7597\u76f8\u5173\u7684\u5e76\u53d1\u75c7\u98ce\u9669\uff0c\u8fd9\u610f\u5473\u7740\u5728\u9009\u62e9\u6cbb\u7597\u65b9\u6848\u65f6\uff0c\u9700\u8981\u4f18\u5148\u8003\u8651\u5982\u4f55\u5e2e\u52a9HIV\u60a3\u8005\u4fdd\u6301\u957f\u671f\u5065\u5eb7\u3002\u201d\u5317\u4eac\u534f\u548c\u533b\u9662\u674e\u592a\u751f\u6559\u6388\u8868\u793a\uff1a\u201c\u4e34\u5e8a\u8bd5\u9a8c\u8868\u660e\uff0c\u5728144\u5468\u7684\u6cbb\u7597\u4e2d\uff0cGenvoya\u8868\u73b0\u51fa\u6301\u7eed\u957f\u4e45\u7684\u75c5\u6bd2\u6291\u5236\u4f5c\u7528\uff0c\u5176\u8868\u73b0\u51fa\u7684\u5b89\u5168\u6027\u6709\u671b\u5e7f\u6cdb\u9002\u7528\u4e8eHIV\u611f\u67d3\u4eba\u7fa4\u3002\u201d<\/span><\/p>\n


<\/p>\n

2017\u5e74\uff0c\u4e2d\u56fd\u7ea6\u670914\u4e07\u540d\u65b0\u786e\u8bca\u7684HIV\u611f\u67d3\u8005 \u3002\u8fd1\u5e74\u6765\uff0c\u7531\u4e8e\u7b5b\u67e5\u8303\u56f4\u7684\u6269\u5927\uff0c\u786e\u8bca\u4eba\u6570\u663e\u8457\u4e0a\u5347\u3002\u540c\u65f6\uff0c\u63a5\u53d7\u6297\u53cd\u8f6c\u5f55\u75c5\u6bd2\u6cbb\u7597\u7684HIV\u611f\u67d3\u8005\u4eba\u6570\u4e5f\u7a33\u6b65\u589e\u52a0\u3002\u81ea2003\u5e74\uff0c\u4e2d\u56fd\u653f\u5e9c\u5f00\u59cb\u201c\u56db\u514d\u4e00\u5173\u6000\u653f\u7b56\u201d\u4e3a\u6240\u6709HIV\u611f\u67d3\u8005\u63d0\u4f9b\u514d\u8d39\u7684\u6297\u53cd\u8f6c\u5f55\u75c5\u6bd2\u6cbb\u7597\u3002<\/span><\/p>\n


<\/p>\n

\u201c\u5409\u5229\u5fb7\u5168\u529b\u652f\u6301\u4e2d\u56fd\u5e94\u5bf9HIV\u75ab\u60c5\u505a\u51fa\u7684\u5de5\u4f5c\uff0c\u540c\u65f6\u6211\u4eec\u4e5f\u975e\u5e38\u9ad8\u5174\u80fd\u591f\u4e3a\u4e2d\u56fd\u7684HIV\u60a3\u8005\u5e26\u6765Genvoya\u8fd9\u4e00\u5168\u65b0\u7684\u6cbb\u7597\u65b9\u6848\u3002\u201d\u5409\u5229\u5fb7\u79d1\u5b66\u516c\u53f8\u603b\u88c1\u53ca\u9996\u5e2d\u6267\u884c\u5b98John F. Milligan\u535a\u58eb\u8868\u793a\uff1a\u201cGenvoya\u662f\u6211\u4eec\u591a\u79cd\u57fa\u4e8eTAF\/FTC\u7684\u6cbb\u7597\u65b9\u6848\u7684\u4e00\u79cd\uff0c\u6211\u4eec\u76f8\u4fe1Genvoya\u8868\u73b0\u51fa\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u80fd\u5e2e\u52a9\u6ee1\u8db3\u4e2d\u56fdHIV\u60a3\u8005\u7fa4\u4f53\u7684\u957f\u671f\u5065\u5eb7\u9700\u6c42\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u4e00\u98793\u671fHIV\u4e34\u5e8a\u8bd5\u9a8c\u5bf9Genvoya\u8fdb\u884c\u4e86\u7814\u7a76\uff0c\u7814\u7a76\u5171\u7eb3\u5165\u4e86\u6765\u81ea21\u4e2a\u56fd\u5bb6\u76843,500\u4f59\u540d\u60a3\u8005\uff0c\u5176\u4e2d\u5305\u62ec\u521d\u6cbb\u3001\u75c5\u6bd2\u6291\u5236\u3001\u80be\u529f\u80fd\u635f\u4f24\u7684\u548c\u9752\u5c11\u5e74\u60a3\u8005\u3002\u6765\u81ea\u4e24\u98793\u671f\u53cc\u76f2\u7814\u7a76\uff08\u7814\u7a76104\u548c\u7814\u7a76111\uff09\u7684144\u5468\u6570\u636e\u4e3aGenvoya\u7684\u5ba1\u6279\u63d0\u4f9b\u4e86\u652f\u6301\uff0c\u7814\u7a76\u4e2d\u7eb3\u5165\u4e861,733\u4f4d\u521d\u6cbb\u60a3\u8005\uff0c\u4e14\u572848\u5468\u65f6\uff0c\u6cbb\u7597\u65b9\u6848\u5b9e\u73b0\u4e86\u975e\u52a3\u6548\u4e8e\u5409\u5229\u5fb7\u516c\u53f8\u7684Stribild\uff08\u827e\u7ef4\u96f7\u97e6150 mg\/\u8003\u6bd4\u53f8\u4ed6150mg\/\u6069\u66f2\u4ed6\u6ee8200mg\/\u5bcc\u9a6c\u9178\u66ff\u8bfa\u798f\u97e6\u4e8c\u5421\u544b\u916f300mg\u6216E\/C\/F\/TDF\uff09\u7684\u4e3b\u8981\u7ec8\u70b9\u300248\u5468\u65f6\uff0c92.4%\uff08n =800\/866\uff09\u670d\u7528Genvoya\u7684\u60a3\u8005\u548c90.4%\uff08n=784\/867  \uff09\u670d\u7528Stribild\u7684\u60a3\u8005\u5b9e\u73b0\u4e86HIV-1 RNA\u6c34\u5e73\u4f4e\u4e8e50\u62f7\u8d1d\/mL\u3002 <\/span><\/p>\n


<\/p>\n

\u6b64\u5916\uff0c\u4e00\u98793\u671f\u7814\u7a76\uff08\u7814\u7a76109\uff09\u4e5f\u4e3aGenvoya\u7684\u5ba1\u6279\u63d0\u4f9b\u4e86\u652f\u6301\uff0c\u8bc4\u4f30\u4e86\u6b64\u524d\u63a5\u53d7\u57fa\u4e8eTDF\u65b9\u6848\u7684\u75c5\u6bd2\u6291\u5236\u60a3\u8005\uff0c\u6362\u7528Genvoya\u7684\u6cbb\u7597\u6548\u679c\u3002\u8be5\u7814\u7a76\u7eb3\u5165\u4e861436\u540d\u53d7\u8bd5\u8005\uff0c\u5176\u4e2d1196\u540d\u5728\u8bd5\u9a8c\u4e2d\u8fbe\u5230\u4e8648\u5468\u7684\u8bc4\u4f30\u65f6\u95f4\u70b9\u3002\u6839\u636e48\u5468\u65f6HIV-1 RNA\u6c34\u5e73\u4f4e\u4e8e50\u62f7\u8d1d\/mL \u7684\u60a3\u8005\u767e\u5206\u6bd4\u6570\u636e\uff0c\u4e0eTDF\u65b9\u6848\u76f8\u6bd4\uff0cGenvoya\u7684\u6cbb\u7597\u65b9\u6848\u8fbe\u5230\u4e86\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u975e\u52a3\u6548\u6027\u3002\u76f8\u6bd4\u4e00\u76f4\u63a5\u53d7\u4ee5TDF\u4e3a\u57fa\u7840\u6cbb\u7597\u65b9\u6848\u7684\u60a3\u8005\uff0c\u63a5\u53d7Genvoya\u6cbb\u7597\u7684\u60a3\u8005\u5728\u80be\u810f\u529f\u80fd\u548c\u9aa8\u9abc\u5b9e\u9a8c\u5ba4\u53c2\u6570\u65b9\u9762\u663e\u8457\u6539\u5584\u3002\u6700\u540e\uff0c\u8bc4\u4f30Genvoya\u7597\u6548\u76843\u671f\u7814\u7a76\u6570\u636e\uff08\u7528\u4e8e\u4f34\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u7684\u9752\u5c11\u5e74\u548c\u6210\u4eba\u60a3\u8005\uff09\u4e5f\u4e3a\u5ba1\u6279\u63d0\u4f9b\u4e86\u652f\u6301\u3002<\/span><\/p>\n


<\/p>\n

\u5173\u4e8e\u5409\u5229\u5fb7\u79d1\u5b66<\/span><\/strong><\/p>\n


<\/p>\n

\u5409\u5229\u5fb7\u79d1\u5b66\u662f\u4e00\u5bb6\u4ee5\u7814\u53d1\u4e3a\u57fa\u7840\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u5728\u672a\u88ab\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u9886\u57df\u53d1\u73b0\u3001\u7814\u53d1\u3001\u5e76\u5546\u4e1a\u5316\u521b\u65b0\u7597\u6cd5\u3002\u516c\u53f8\u7684\u4f7f\u547d\u662f\u53d8\u9769\u5e76\u7b80\u5316\u5168\u7403\u91cd\u75be\u60a3\u8005\u7684\u6cbb\u7597\u65b9\u6848\u3002\u5409\u5229\u5fb7\u5728\u5168\u4e16\u754c\u8d85\u8fc735\u4e2a\u56fd\u5bb6\u8fdb\u884c\u8fd0\u8425\uff0c\u603b\u90e8\u4f4d\u4e8e\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u7684\u798f\u65af\u7279\u5e02\u3002<\/span><\/p>\n


<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u533b\u836f\u9b54\u65b9 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5409\u5229\u5fb7\u79d1\u5b66\u516c\u53f88\u67086\u65e5\u5ba3\u5e03\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6Genvoya\uff08\u827e\u8003\u6069\u4e19\u66ff\u7247\uff0c\u5373E\/C\/F\/TAF\uff0c\u4e2d\u6587\u5546\u54c1 […]<\/p>\n","protected":false},"author":1,"featured_media":30165,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30164"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=30164"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30164\/revisions"}],"predecessor-version":[{"id":30170,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30164\/revisions\/30170"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/30165"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=30164"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=30164"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=30164"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}