{"id":30363,"date":"2018-08-06T01:00:00","date_gmt":"2018-08-09T04:08:11","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e8%a2%ab%e9%81%97%e5%bf%98%e7%bd%95%e8%a7%81%e7%97%85%e6%9c%89%e4%ba%86%e5%b8%8c%e6%9c%9b%ef%bc%81%e5%8f%b8%e7%be%8e%e6%9b%bf%e5%b0%bc%e8%8e%b7%e5%ad%a4%e5%84%bf%e8%8d%af%e8%b5%84%e6%a0%bc\/"},"modified":"2018-08-09T12:08:13","modified_gmt":"2018-08-09T04:08:13","slug":"%e8%a2%ab%e9%81%97%e5%bf%98%e7%bd%95%e8%a7%81%e7%97%85%e6%9c%89%e4%ba%86%e5%b8%8c%e6%9c%9b%ef%bc%81%e5%8f%b8%e7%be%8e%e6%9b%bf%e5%b0%bc%e8%8e%b7%e5%ad%a4%e5%84%bf%e8%8d%af%e8%b5%84%e6%a0%bc","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/30363\/","title":{"rendered":"\u88ab\u9057\u5fd8\u7f55\u89c1\u75c5\u6709\u4e86\u5e0c\u671b\uff01\u53f8\u7f8e\u66ff\u5c3c\u83b7\u5b64\u513f\u836f\u8d44\u683c"},"content":{"rendered":"
\n

\u7f55\u89c1\u80bf\u7624\u4e0d\u7f55\u89c1\uff0cTA\u5f71\u54cd3000\u65b0\u751f\u513f\u4e2d\u7684\u4e00\u4e2a\uff0c\u4f46\u662f\uff0c\u7b2c\u4e00\u6279\u56fd\u5bb6\u7f55\u89c1\u75c5\u76ee\u5f55\u4e2d\u5374\u6ca1\u6709TA\u7684\u8eab\u5f71\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u79cd\u7f55\u89c1\u80bf\u7624\u5c31\u662f\u795e\u7ecf\u7ea4\u7ef4\u7624\uff0c\u53c8\u53eb  Neurofibromatosis(NF )\u3002<\/span><\/p>\n


<\/p>\n

NF1\u662f\u4e00\u79cd\u65e0\u6cd5\u6cbb\u6108\u7684\u9057\u4f20\u75be\u75c5\uff0c\u5176\u75c7\u72b6\u7684\u4e25\u91cd\u6027\u53c8\u662f\u4e0d\u65ad\u8fdb\u884c\u7684, \u901a\u5e38\u662f\u4ece\u8f7b\u5ea6\u5230\u4e2d\u5ea6, \u75c7\u72b6\u53ef\u80fd\u5305\u62ec\u76ae\u80a4\u3001\u795e\u7ecf\u548c\u9aa8\u9abc\u65b9\u9762\u8868\u73b0\u3002<\/span><\/p>\n


<\/p>\n

\u56e0\u4e3a\u80bf\u7624\u4e3b\u8981\u751f\u957f\u5728\u795e\u7ecf\u7cfb\u7edf\uff0c\u56e0\u6b64\u5f97\u540d\u3002\u901a\u5e38\u75c7\u72b6\u51fa\u73b0\u5728\u51fa\u751f\u65f6\uff0c\u6709\u7684\u4f1a\u5230\u6210\u5e74\u65e9\u671f\uff0c\u4f46\u662f\u75c7\u72b6\u5374\u7ec8\u8eab\u76f8\u4f34\u3002<\/span><\/p>\n


<\/p>\n

\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c5\u4e3b\u8981\u5206\u4e3a\u4e09\u79cd\u7c7b\u578b\uff1a<\/span><\/p>\n

1.\t<\/span>\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c51\u578b\uff08NF1\uff09<\/span><\/p>\n

2.\t<\/span>\u795e\u7ecf\u7ea4\u7ef4\u7624\u75c52\u578b\uff08NF2\uff09<\/span><\/p>\n

3.\t<\/span>\u795e\u7ecf\u9798\u7624\u75c5<\/span><\/p>\n


<\/p>\n

NF1\u5c5e\u4e8e\u76f8\u5bf9\u8f83\u8f7b\u7684\u7c7b\u578b\uff0c\u60a3\u8005\u9884\u540e\u53ef\u4ee5\u6709\u6b63\u5e38\u9884\u671f\u5bff\u547d\u3002\u4f46\u662f\uff0cNF2\u7684\u9884\u540e\u5219\u76f8\u5bf9\u8f83\u5dee\uff0c\u9884\u671f\u5bff\u547d\u4f1a\u7f29\u77ed\u3002<\/span><\/p>\n


<\/p>\n

\u201cNF\u662f\u4e00\u79cd\u5355\u57fa\u56e0\u663e\u6027\u9057\u4f20\u75be\u75c5, \u2026\u76ee\u524d\u9664\u4e86\u624b\u672f\u5916\u65e0\u4efb\u4f55\u6709\u6548\u529e\u6cd5\u3002\u5b83\u53ef\u4ee5\u5728\u8eab\u4f53\u4efb\u4f55\u90e8\u4f4d\u53d1\u751f\u80bf\u7624\u3002\u5305\u62ec\u76ae\u80a4\uff0c\u9aa8\u9abc\uff0c\u5668\u5b98\u7b49\u5916\u5468\u795e\u7ecf\uff0c\u53d1\u751f\u4e8e\u4e2d\u67a2\u795e\u7ecf\u9885\u5185\u80bf\u7624\uff0c\u690e\u7ba1\u80bf\u7624\u7b49\uff01\u8d8a\u957f\u8d8a\u591a\uff01\u201dNF\u5bb6\u56ed\u7684\u8d1f\u8d23\u4eba\u544a\u8bc9\u5065\u70b9\u5b50ihealth\u5c0f\u7f16\u3002<\/span><\/p>\n


<\/span><\/p>\n<\/p>\n


<\/span><\/p>\n

\u76ee\u524d\uff0c\u4e00\u4e2a\u6b63\u5728\u7814\u7a76\u6cbb\u7597NF\u7684\u5c0f\u5206\u5b50\u836f\u559c\u83b7\u6b27\u76df\u5b64\u513f\u836f\u8d44\u683c\u3002<\/span><\/p>\n


<\/p>\n

\u53f8\u7f8e\u66ff\u5c3c\uff08selumetinib \uff09<\/span>\u5728 NF1 \u4e2d\u7684\u6f5c\u5728\u76ca\u5904\u6b63\u5728\u7814\u7a76\u4e2d, \u76ee\u524d\u6b63\u5728\u5728\u513f\u7ae5\u60a3\u8005\u4e2d\u6cbb\u7597\u6ca1\u6709\u7ecf\u8fc7\u624b\u672f\u6cbb\u7597\u7684 NF1\u76f8\u5173\u7684\u7f51\u72b6\u795e\u7ecf\u7ea4\u7ef4\u7624 \u7b2c\u4e00\/\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n


<\/p>\n

NF\u662f\u826f\u6027\u795e\u7ecf\u9798,\u80bf\u7624\u7684<\/span> \u5f71\u54cd20-50% \u7684\u75c5\u4eba, \u5e76\u968f\u7740\u80bf\u7624\u7684\u7ee7\u7eed\u589e\u52a0, \u9020\u6210\u4e2d\u7b49\u81f3\u4e25\u91cd\u53d1\u75c5, \u5982\u75bc\u75db, \u8fd0\u52a8\u969c\u788d\u548c\u7578\u5f62\u3002<\/span><\/p>\n


<\/p>\n

“\u76ee\u524d\u5bf9\u8fd9\u4e9b\u75c5\u4eba\u7684\u6cbb\u7597\u9009\u62e9\u975e\u5e38\u6709\u9650, \u6ca1\u6709\u6cbb\u7597 NF1 \u7684\u65b9\u6cd5, ” \u963f\u65af\u5229\u5eb7\u516c\u53f8\u7684\u6267\u884c\u526f\u603b\u88c1, \u5168\u7403\u836f\u7269\u5f00\u53d1\u548c\u9996\u5e2d\u533b\u7597\u529e\u516c\u5ba4\u7684Sean Bohen \u8868\u793a\u8bf4\u3002<\/span><\/p>\n


<\/span><\/p>\n

“\u7ed9\u4e88\u8fd9\u4e2a\u5b64\u513f\u8d44\u683c\u662f NF1 \u53ca\u5176\u5bb6\u5ead\u5411\u524d\u8fdb\u6b65\u7684\u79ef\u6781\u4e00\u6b65”\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u9884\u8ba1\u5c06\u4e8e<\/span>\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u5c31\u4f1a\u53d6\u5f97\u4e3b\u8981\u7ed3\u679c<\/span>\u3002<\/span><\/p>\n


<\/p>\n

Selumetinib \u901a\u8fc7\u6291\u5236neurofibromin\u9014\u5f84\u4e2d\u7684\u916e\u9176, \u53ef\u80fd\u6291\u5236\u80bf\u7624\u751f\u957f\u3002<\/span>\u53f8\u7f8e\u66ff\u5c3c\u4e5f\u6b63\u5728\u88ab\u63a2\u7d22\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5, \u5e76\u7ed3\u5408\u5176\u4ed6\u6cbb\u7597\u6b63\u5728\u8fdb\u884c\u8bd5\u9a8c\u3002<\/span><\/p>\n


<\/p>\n

\u963f\u65af\u5229\u5eb7\uff08AstraZeneca\uff09\u548c\u9ed8\u6c99\u4e1c\uff08MSD\uff09\u57282017\u5e747\u6708\u5ba3\u5e03\u4e86\u5168\u7403\u6218\u7565\u5408\u4f5c<\/span>, \u5171\u540c\u5f00\u53d1\u548c\u4e0a\u5e02 <\/span>Lynparza<\/strong><\/span>, \u4e16\u754c\u4e0a\u7b2c\u4e00\u4e2a PARP \u6291\u5236\u5242\uff0c\u6cbb\u7597\u5375\u5de2\u764c\u548c\u4e73\u817a\u764c\u3002<\/span><\/p>\n


<\/p>\n

\u4f5c\u4e3a\u5408\u4f5c\u7684\u4e00\u90e8\u5206\uff0c\u53cc\u65b9\u8fd8\u5c06\u5e76\u7ed3\u5408\u5176\u4ed6\u6f5c\u5728\u7684\u65b0\u836f\u5305\u62ec\u80bf\u7624\u514d\u75abPD-1\u548cPD-L1\u7597\u6cd5\uff0c<\/span>\u5f00\u53d1 Lynparza \u548c selumetinib, <\/span>\u4f5c\u4e3a\u72ec\u7acb\u6216\u8005\u7ec4\u5408\u7528\u836f\u6cbb\u7597\u5b9e\u4f53\u80bf\u7624\u3002<\/span><\/p>\n


<\/p>\n

\u4f60\u5bf9\u8fd9\u4e2a\u7f55\u89c1\u75c5\u7684\u5b64\u513f\u836f\u8d44\u683c\u600e\u4e48\u770b\uff1f<\/span><\/em><\/p>\n

\u8bf7\u7559\u8a00\u5206\u4eab\u770b\u6cd5<\/span><\/em>\u3002<\/span><\/p>\n


<\/p>\n

\u53c2\u8003\u6587\u7ae0<\/span><\/strong>\uff1a<\/span><\/p>\n

http:\/\/www.pharmatimes.com\/news\/az_and_msd_get_orphan_designation_for_neurofibromatosis_drug_1246924<\/span><\/p>\n


<\/p>\n

\u4f60\u53ef\u80fd\u559c\u6b22<\/span><\/strong>\uff1a<\/span><\/p>\n

\u88ab\u9057\u5fd8\u7684\u7f55\u89c1\u75c5\uff1a\u76ee\u5f55\u4e3a\u4ec0\u4e48\u6ca1\u6709\u8fd9\u79cd\u513f\u7ae5\u80bf\u7624\uff1f<\/span><\/a>
<\/p>\n


<\/p>\n

\u670d\u52a1\u65b0\u836f\u7814\u53d1 \u628a\u63e1\u6295\u8d44\u8d8b\u52bf<\/span><\/em><\/span><\/p>\n

\u6bcf\u5929\u7528\u65b0\u8bf4\u8bdd \u51b3\u7b56\u4e0d\u53ef\u6216\u7f3a<\/span><\/em><\/span><\/p>\n

\u5065\u70b9\u5b50ihealth<\/em><\/strong>\u662f\u533b\u836f\u884c\u4e1a\u9886\u5148\u7684\u6295\u8d44\u987e\u95ee\u8d44\u8baf\u5e73\u53f0\uff0c\u4e13\u6ce8<\/em>\u7f55\u89c1\u75c5\uff0c<\/strong>\u751f\u7269\u7c7b\u4f3c\u836f\uff0c<\/strong><\/em>\u65e5\u97e9\u5370\u5ea6<\/strong><\/em>\u5065\u5eb7\u884c\u4e1a\u7684\u6700\u65b0\u52a8\u5411\u3002<\/em><\/span><\/p>\n

\u4f60\u53ef\u4ee5\u5728\u4efb\u4f55\u5065\u70b9\u5b50\u6587\u7ae0\u540e\u7559\u8a00\u3002\u8bf7\u7b80\u77ed\u8bf4\u660e\u5177\u4f53\u9700\u6c42\u3002\u6211\u4eec\u4e00\u822c\u572824\u5c0f\u65f6\u4e4b\u5185\u8054\u7cfb\u3002<\/em><\/span><\/p>\n

\"\u88ab\u9057\u5fd8\u7f55\u89c1\u75c5\u6709\u4e86\u5e0c\u671b\uff01\u53f8\u7f8e\u66ff\u5c3c\u83b7\u5b64\u513f\u836f\u8d44\u683c\"<\/em><\/em><\/span><\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u5065\u70b9\u5b50ihealth <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u7f55\u89c1\u80bf\u7624\u4e0d\u7f55\u89c1\uff0cTA\u5f71\u54cd3000\u65b0\u751f\u513f\u4e2d\u7684\u4e00\u4e2a\uff0c\u4f46\u662f\uff0c\u7b2c\u4e00\u6279\u56fd\u5bb6\u7f55\u89c1\u75c5\u76ee\u5f55\u4e2d\u5374\u6ca1\u6709TA\u7684\u8eab\u5f71\u3002 \u8fd9\u79cd\u7f55\u89c1\u80bf\u7624\u5c31 […]<\/p>\n","protected":false},"author":1,"featured_media":30364,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30363"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=30363"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30363\/revisions"}],"predecessor-version":[{"id":30370,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30363\/revisions\/30370"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/30364"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=30363"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=30363"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=30363"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}