{"id":3067,"date":"2018-07-05T01:00:00","date_gmt":"2018-07-27T06:41:59","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e8%bf%91%e5%8d%81%e5%b9%b4%e8%a2%ab%e6%89%b9%e5%87%86%e7%9a%84%e6%b2%bb%e7%96%97%e7%97%9b%e9%a3%8e%e7%9a%84%e8%8d%af%e7%89%a9\/"},"modified":"2018-07-27T14:42:00","modified_gmt":"2018-07-27T06:42:00","slug":"%e8%bf%91%e5%8d%81%e5%b9%b4%e8%a2%ab%e6%89%b9%e5%87%86%e7%9a%84%e6%b2%bb%e7%96%97%e7%97%9b%e9%a3%8e%e7%9a%84%e8%8d%af%e7%89%a9","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/3067\/","title":{"rendered":"\u8fd1\u5341\u5e74\u88ab\u6279\u51c6\u7684\u6cbb\u7597\u75db\u98ce\u7684\u836f\u7269"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress7-1532673719.jpeg\" alt=\"\u8fd1\u5341\u5e74\u88ab\u6279\u51c6\u7684\u6cbb\u7597\u75db\u98ce\u7684\u836f\u7269\" title=\"\u8fd1\u5341\u5e74\u88ab\u6279\u51c6\u7684\u6cbb\u7597\u75db\u98ce\u7684\u836f\u7269\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u9ad8\u5c3f\u9178\u8840\u75c7(HUA)\u662f\u56e0\u4eba\u4f53\u5185\u560c\u5464\u65b0\u9648\u4ee3\u8c22\u7d0a\u4e71\u3001\u8840\u6db2\u4e2d\u5c3f\u9178\u6c34\u5e73\u6301\u7eed\u589e\u9ad8\uff0c\u5bfc\u81f4\u8fc7\u9971\u548c\u72b6\u6001\u7684\u5c3f\u9178\u7ed3\u6676\u6c89\u79ef\u5728\u7ec4\u7ec7\u4e2d\uff0c\u8fdb\u800c\u4f7f\u6709\u4e9b\u4eba\u51fa\u73b0\u75db\u98ce\u3002\u7ea620%\u7684\u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u8005\u4f1a\u51fa\u73b0\u75db\u98ce\u7684\u75c7\u72b6\uff0c\u5176\u4f5980%\u6ca1\u6709\u75c7\u72b6\u3002\u75db\u98ce\u4e3b\u8981\u7279\u5f81\u5305\u62ec\u5c3f\u9178\u77f3\u3001\u80be\u5b9e\u8d28\u6027\u75c5\u53d8\u3001\u75db\u98ce\u77f3\u6c89\u79ef\u3001\u6025\u6027\u75db\u98ce\u5173\u8282\u708e\u53cd\u590d\u53d1\u4f5c\u3001\u6162\u6027\u75db\u98ce\u6027\u5173\u8282\u708e\u548c\u5173\u8282\u7578\u5f62\u7b49\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress1-1532673720.jpg\" alt=\"\u8fd1\u5341\u5e74\u88ab\u6279\u51c6\u7684\u6cbb\u7597\u75db\u98ce\u7684\u836f\u7269\" title=\"\u8fd1\u5341\u5e74\u88ab\u6279\u51c6\u7684\u6cbb\u7597\u75db\u98ce\u7684\u836f\u7269\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u73b0\u4ee3\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u8868\u660e\uff0c\u75db\u98ce\u7684\u60a3\u75c5\u7387\u56e0\u5730\u57df\u3001\u6027\u522b\u4e0d\u540c\u5dee\u5f02\u5f88\u5927\u3002\u6cbf\u6d77\u3001\u53d1\u8fbe\u5730\u533a\u75db\u98ce\u60a3\u75c5\u7387\u9ad8\u4e8e\u53d1\u5c55\u5185\u9646\u5730\u533a\uff0c\u7a76\u5176\u539f\u56e0\uff0c\u6cbf\u6d77\u3001\u53d1\u8fbe\u5730\u533a\u662f\u7531\u98df\u7528\u6d77\u9c9c\u7b49\u9ad8\u560c\u5464\u98df\u7269\u8f83\u591a\u5bfc\u81f4\u7684\uff1b2013\u5e74\u6211\u56fdHUA\u60a3\u75c5\u7387\u7537\u6027\u7ea6\u4e3a16.85%\uff0c\u5973\u6027\u7ea6\u4e3a7.88%, \u75db\u98ce\u60a3\u75c5\u7387\u7537\u6027\u7ea6\u4e3a1.98%, \u5973\u6027\u7ea6\u4e3a0.72%, \u8f83\u4ee5\u524d\u660e\u663e\u4e0a\u5347\u3002\u968f\u7740\u4eba\u4eec\u996e\u98df\u7ed3\u6784\u7684\u6539\u53d8\uff0c\u66f4\u591a\u5730\u6444\u5165\u9ad8\u86cb\u767d\u9ad8\u560c\u5464\u7c7b\u5316\u5408\u7269\u7684\u98df\u7269\uff0c\u5bfc\u81f4\u60a3\u75c5\u7387\u8d8a\u6765\u8d8a\u9ad8\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u5728\u836f\u7269\u7814\u53d1\u9886\u57df\uff0c\u6297\u75db\u98ce\u836f\u4e5f\u662f\u70ed\u95e8\u9886\u57df\uff0c\u8fd1\u5e74\u6765\u6709\u591a\u4e2a\u6297\u75db\u98ce\u836f\u7269\u7ecf\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\u3002\u8fd9\u4e00\u9636\u6bb5\u9700\u4f7f\u7528\u964d\u5c3f\u9178\u836f\u63a7\u5236\u8840\u5c3f\u9178\u6c34\u5e73\uff0c\u964d\u5c3f\u9178\u836f\u7269\u6309\u4f5c\u7528\u673a\u5236\u53ef\u5206\u4e3a\u6291\u5236\u5c3f\u9178\u751f\u6210\u836f\u3001\u4fc3\u5c3f\u9178\u6392\u6cc4\u836f\u53ca\u5206\u89e3\u5c3f\u9178\u7684\u5c3f\u9178\u9176\u4e09\u7c7b\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;color: rgb(51, 51, 51);\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section style=\"margin-top: 15px;margin-bottom: 15px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;word-wrap: break-word !important;\">\n<section style=\"margin-left: auto;max-width: 100%;box-sizing: border-box;width: 45px;height: 5px;line-height: 5px;color: rgb(255, 255, 255);background-color: rgb(68, 120, 242);word-wrap: break-word !important;\"><\/section>\n<section style=\"margin-top: -3px;margin-bottom: -3px;padding-right: 8px;padding-left: 8px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: solid;border-color: rgb(0, 0, 0);color: rgb(62, 62, 62);letter-spacing: 0px;line-height: 1.75;transform: rotate(0deg);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u975e\u5e03\u53f8\u4ed6<\/strong><\/span><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;width: 45px;height: 5px;line-height: 5px;color: rgb(255, 255, 255);background-color: rgb(68, 120, 242);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u975e\u5e03\u53f8\u4ed6(Febuxostat)\u662f\u4e00\u79cd\u53e3\u670d\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6291\u5236\u5242\uff0c\u4e0d\u540c\u4e8e\u522b\u560c\u9187\u53ca\u5176\u6d3b\u6027\u4ee3\u8c22\u7269\u7f9f\u57fa\u560c\u5464\u9187\uff0c \u975e\u5e03\u53f8\u4ed6\u662f\u975e\u560c\u5464\u7c7b\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6291\u5236\u5242\uff0c\u5e76\u4e14\u4ec5\u6291\u5236\u9ec4\u560c\u5464\u6c27\u5316\u9176\uff0c\u800c\u4e0d\u6291\u5236\u560c\u5464\u548c\u5627\u5576\u4ee3\u8c22\u9014\u5f84\u4e2d\u7684\u9176\uff0c\u7ade\u4e89\u6027\u5730\u6291\u5236\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6765\u963b\u65ad\u6b21\u9ec4\u560c\u5464\u7684\u8f6c\u5316\uff0c\u4ece\u800c\u51cf\u5c11\u560c\u5464\u6838\u82f7\u9178\u7684\u751f\u6210\uff0c\u4ece\u6e90\u5934\u4e0a\u6291\u5236\u5c3f\u9178\u7684\u4ea7\u751f\uff0c\u63a7\u5236\u8840\u5c3f\u9178\u6c34\u5e73\u30022009\u5e74\u7531\u7f8e\u56fdFDA \u6279\u51c6\u975e\u5e03\u53f8\u4ed6\u7528\u4e8e\u75db\u98ce\u7684\u6cbb\u7597\uff0c \u5242\u91cf\u4e3a 40-80 mg\/d, \u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u80be\u8870\u7aed\u7684\u60a3\u8005\u4f7f\u7528\u975e\u5e03\u53f8\u4ed6\u65f6\u4e0d\u9700\u8981\u8c03\u6574\u5242\u91cf\u3002\u975e\u5e03\u53f8\u4ed6\u4e0d\u826f\u53cd\u5e94\u8f83\u8f7b\uff0c\u4e3b\u8981\u5305\u62ec\u8fc7\u654f\u3001\u76ae\u75b9\u7b49\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532673720.png\" alt=\"\u8fd1\u5341\u5e74\u88ab\u6279\u51c6\u7684\u6cbb\u7597\u75db\u98ce\u7684\u836f\u7269\" title=\"\u8fd1\u5341\u5e74\u88ab\u6279\u51c6\u7684\u6cbb\u7597\u75db\u98ce\u7684\u836f\u7269\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">Febuxostat\u7684\u5316\u5b66\u7ed3\u6784\u5f0f<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;color: rgb(51, 51, 51);\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section style=\"margin-top: 15px;margin-bottom: 15px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;word-wrap: break-word !important;\">\n<section style=\"margin-left: auto;max-width: 100%;box-sizing: border-box;width: 45px;height: 5px;line-height: 5px;color: rgb(255, 255, 255);background-color: rgb(68, 120, 242);word-wrap: break-word !important;\"><\/section>\n<section style=\"margin-top: -3px;margin-bottom: -3px;padding-right: 8px;padding-left: 8px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: solid;border-color: rgb(0, 0, 0);color: rgb(62, 62, 62);letter-spacing: 0px;line-height: 1.75;transform: rotate(0deg);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6258\u5339\u53f8\u4ed6<\/strong><\/span><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;width: 45px;height: 5px;line-height: 5px;color: rgb(255, 255, 255);background-color: rgb(68, 120, 242);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u6258\u5339\u53f8\u4ed6(Topiroxostat)\u662f\u4e00\u79cd\u65b0\u7684\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6291\u5236\u5242\uff0c\u4e8e2013\u5e74\u5728\u65e5\u672c\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u662f\u4e5f\u975e\u560c\u5464\u7c7b\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6291\u5236\u5242\uff0c\u5176\u964d\u5c3f\u9178\u4f18\u4e8e\u522b\u560c\u5464\u9187\uff0c\u4f46\u4f4e\u4e8e\u975e\u5e03\u53f8\u4ed6\u3002\u6258\u5339\u53f8\u4ed6\u5fc3\u8840\u7ba1\u7cfb\u7edf\u7684\u4e0d\u826f\u53cd\u5e94\u5c11\uff0c\u53ef\u964d\u4f4e\u6162\u6027\u80be\u810f\u75c5\u2162\u671f\u4e14\u4f34\u6709\u75db\u98ce\u75c7\u60a3\u8005\u7684\u9ad8\u5c3f\u9178\u6c34\u5e73\uff0c\u5b89\u5168\u6027\u8f83\u597d\u3002\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u809d\u529f\u80fd\u5f02\u5e38\u3001\u8179\u6cfb\u3001\u5934\u75db\u3001\u6076\u5fc3\u53ca\u76ae\u75b9\u7b49\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress7-1532673720.png\" alt=\"\u8fd1\u5341\u5e74\u88ab\u6279\u51c6\u7684\u6cbb\u7597\u75db\u98ce\u7684\u836f\u7269\" title=\"\u8fd1\u5341\u5e74\u88ab\u6279\u51c6\u7684\u6cbb\u7597\u75db\u98ce\u7684\u836f\u7269\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">Topiroxostat\u7684\u5316\u5b66\u7ed3\u6784\u5f0f<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;color: rgb(51, 51, 51);\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section style=\"margin-top: 15px;margin-bottom: 15px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;word-wrap: break-word !important;\">\n<section style=\"margin-left: auto;max-width: 100%;box-sizing: border-box;width: 45px;height: 5px;line-height: 5px;color: rgb(255, 255, 255);background-color: rgb(68, 120, 242);word-wrap: break-word !important;\"><\/section>\n<section style=\"margin-top: -3px;margin-bottom: -3px;padding-right: 8px;padding-left: 8px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: solid;border-color: rgb(0, 0, 0);color: rgb(62, 62, 62);letter-spacing: 0px;line-height: 1.75;transform: rotate(0deg);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">Lesinurad<\/span><\/strong><\/span><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;width: 45px;height: 5px;line-height: 5px;color: rgb(255, 255, 255);background-color: rgb(68, 120, 242);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">Lesinurad\u4e8e2015\u5e7412\u6708\u7531\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u9ad8\u5c3f\u9178\u8840\u75c7\u53ca\u75db\u98ce\u3002<\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">Lesinurad\u662fURAT1\u548cOAT4\u5c3f\u9178\u80be\u810f\u8f6c\u8fd0\u4f53\u7684\u9009\u62e9\u6027\u6291\u5236\u5242\u3002URAT1\u5c5e\u4e8eOAT(\u6709\u673a\u9634\u79bb\u5b50\u8f6c\u8fd0\u86cb\u767d)\u5bb6\u65cf\uff0cURAT1\u548cOAT4\u5728\u5c3f\u9178\u7684\u91cd\u5438\u6536\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0cLesinurad\u901a\u8fc7\u6291\u5236URAT1\u548cOAT4\uff0c\u8fdb\u800c\u963b\u6b62\u5c3f\u9178\u7684\u91cd\u5438\u6536\uff0c\u8fbe\u5230\u52a0\u901f\u5c3f\u9178\u6392\u6cc4\uff0c\u8d77\u5230\u964d\u4f4e\u5c3f\u9178\u7684\u4f5c\u7528\u3002\u4e0e\u5176\u4ed6\u7684\u4fc3\u5c3f\u9178\u6392\u6cc4\u836f\u76f8\u6bd4\uff0cLesinurad\u5e76\u4e0d\u5f71\u54cdGLUT9\u3001ABCG2\u7b49\u5916\u4fa7\u7684\u57fa\u5e95\u8f6c\u8fd0\u86cb\u767d\uff0c\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u98ce\u9669\u8f83\u4f4e\uff0c\u4e14Lesinurad\u5bf9\u7ebf\u7c92\u4f53\u6bd2\u6027\u4f4e\uff0c\u6240\u4ee5\u88ab\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u589e\u6b96\u7269\u6fc0\u6d3b\u53d7\u4f53\u03b3 (PPAR\u03b3)\u8bf1\u5bfc\u7684\u98ce\u9669\u8f83\u4f4e\u3002Lesinurad\u8d77\u6548\u8fc5\u901f\uff0c\u5728\u53e3\u670d1-4\u5c0f\u65f6\u5185\u8fbe\u5230\u6700\u9ad8\u8840\u836f\u6d53\u5ea6\u3002\u7531CYP2C9 \u4ee3\u8c22\u4e4b\u540e\uff0c\u968f\u5c3f\u6db2\u6392\u51fa\u4f53\u5916\u3002\u6b64\u5916\uff0cLesinurad\u4e0e\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6291\u5236\u5242\u522b\u560c\u5464\u9187\u3001\u975e\u5e03\u53f8\u4ed6\u8054\u7528\u53ef\u4ee5\u7528\u4e8e\u5355\u72ec\u4f7f\u7528\u9ec4\u560c\u5464\u6c27\u5316\u9176\u6291\u5236\u5242\u540e\u5c3f\u9178\u672a\u964d\u4f4e\u7684\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: auto !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress3-1532673720-1.png\" alt=\"\u8fd1\u5341\u5e74\u88ab\u6279\u51c6\u7684\u6cbb\u7597\u75db\u98ce\u7684\u836f\u7269\" title=\"\u8fd1\u5341\u5e74\u88ab\u6279\u51c6\u7684\u6cbb\u7597\u75db\u98ce\u7684\u836f\u7269\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">Lesinurad\u7684\u5316\u5b66\u7ed3\u6784\u5f0f<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;color: rgb(51, 51, 51);\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section style=\"margin-top: 15px;margin-bottom: 15px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;word-wrap: break-word !important;\">\n<section style=\"margin-left: auto;max-width: 100%;box-sizing: border-box;width: 45px;height: 5px;line-height: 5px;color: rgb(255, 255, 255);background-color: rgb(68, 120, 242);word-wrap: break-word !important;\"><\/section>\n<section style=\"margin-top: -3px;margin-bottom: -3px;padding-right: 8px;padding-left: 8px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: solid;border-color: rgb(0, 0, 0);color: rgb(62, 62, 62);letter-spacing: 0px;line-height: 1.75;transform: rotate(0deg);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">Duzallo<\/span><\/strong><\/span><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;width: 45px;height: 5px;line-height: 5px;color: rgb(255, 255, 255);background-color: rgb(68, 120, 242);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">Duzallo\u4e8e2017\u5e748\u6708\u7531\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u8be5\u836f\u4e3aLesinurad\u4e0e\u522b\u560c\u5464\u9187\u7684\u56fa\u5b9a\u5242\u91cf\u7ec4\u5408\uff0cDuzallo\u662f\u4e00\u65e5\u4e00\u6b21\u53e3\u670d\u836f\u7269\uff0c\u6709200 mg Zurampic\u52a0200\u6216300 mg\u522b\u560c\u5464\u9187\u4e24\u4e2a\u5242\u91cf\u3002\u8054\u5408\u4f7f\u7528Zurampic\u548c\u522b\u560c\u5464\u9187\u6bd4\u5355\u72ec\u4f7f\u7528\u522b\u560c\u5464\u9187\u5c3f\u9178\u63a7\u5236\u57286 mg\/dL\u7684\u4eba\u6570\u51e0\u4e4e\u7ffb\u500d\u3002\u522b\u560c\u5464\u9187\u51cf\u5c11\u5c3f\u9178(UA)\u7684\u4ea7\u751f\uff0cLesinurad\u901a\u8fc7\u9009\u62e9\u6027\u5730\u6291\u5236\u5c3f\u9178\u5728\u80be\u810f\u7684\u91cd\u5438\u6536\uff0c\u8fdb\u800c\u589e\u52a0\u5c3f\u9178\u7684\u80be\u6392\u6cc4\u3002 Duzallo\u7684\u53cc\u91cd\u673a\u5236\u7ec4\u5408\u53ef\u4ee5\u89e3\u51b3\u5c3f\u9178\u7684\u4f4e\u6548\u6392\u6cc4\u548c\u8fc7\u91cf\u751f\u4ea7\uff0c\u4ece\u800c\u964d\u4f4e\u4f53\u5185\u5c3f\u9178\u6c34\u5e73\u3002\u4f46\u8be5\u836f\u7269\u4e0d\u63a8\u8350\u65e0\u75c7\u72b6\u9ad8\u5c3f\u9178\u8840\u75c7\u60a3\u8005\u4f7f\u7528\u3002\u5176\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\uff1a\u6025\u6027\u80be\u635f\u4f24\u3001\u809d\u6bd2\u6027\u3001\u5fc3\u810f\u6bd2\u6027\u3001\u55dc\u7761\u7b49\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;color: rgb(51, 51, 51);\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section style=\"margin-top: 15px;margin-bottom: 15px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;word-wrap: break-word !important;\">\n<section style=\"margin-left: auto;max-width: 100%;box-sizing: border-box;width: 45px;height: 5px;line-height: 5px;color: rgb(255, 255, 255);background-color: rgb(68, 120, 242);word-wrap: break-word !important;\"><\/section>\n<section style=\"margin-top: -3px;margin-bottom: -3px;padding-right: 8px;padding-left: 8px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: solid;border-color: rgb(0, 0, 0);color: rgb(62, 62, 62);letter-spacing: 0px;line-height: 1.75;transform: rotate(0deg);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u805a\u4e59\u4e8c\u9187\u91cd\u7ec4\u5c3f\u9178\u9176(Krystexxa)<\/span><\/strong><\/span><\/p>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;width: 45px;height: 5px;line-height: 5px;color: rgb(255, 255, 255);background-color: rgb(68, 120, 242);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u5c3f\u9178\u9176\u662f\u4e00\u79cd\u5c06\u5c3f\u9178\u5206\u89e3\u4e3a\u66f4\u6eb6\u4e8e\u6c34\u7684\u5c3f\u56ca\u7d20\u9176\uff0c\u901a\u8fc7\u4fc3\u8fdb\u5c3f\u9178\u5206\u89e3\u964d\u4f4e\u5c3f\u9178\u3002Krystexxa\u57282014\u5e74\u7531\u7f8e\u56fdFDA 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style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;color: rgb(51, 51, 51);\">\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section style=\"margin-top: 15px;margin-bottom: 15px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: 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href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231395&amp;idx=1&amp;sn=82b2e145bdd8711af2f6c8893456540f&amp;chksm=84be7b38b3c9f22e034b9d2e1eac88905f0d7157281960b676a50e597de212fc8af967145eb2&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u3010\u6848\u4f8b\u8bf4\u3011\u6570\u636e&amp;\u4e34\u5e8a\u4e4b\u771f\u5b9e\u4e16\u754c\u7814\u7a76<\/a><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA3NjU4NjE2NA==&amp;mid=2652231751&amp;idx=1&amp;sn=dce65e202747c083d07e8f2a0f1afea1&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6211\u4eec\u7684\u6bd5\u4e1a\u5b63<\/a><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\">\n<p><br  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u6c47\u805a\u5357\u836f                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u9ad8\u5c3f\u9178\u8840\u75c7(HUA)\u662f\u56e0\u4eba\u4f53\u5185\u560c\u5464\u65b0\u9648\u4ee3\u8c22\u7d0a\u4e71\u3001\u8840\u6db2\u4e2d\u5c3f\u9178\u6c34\u5e73\u6301\u7eed\u589e\u9ad8\uff0c\u5bfc\u81f4\u8fc7\u9971\u548c\u72b6\u6001\u7684\u5c3f\u9178\u7ed3\u6676\u6c89\u79ef\u5728\u7ec4\u7ec7\u4e2d\uff0c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3068,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/3067"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=3067"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/3067\/revisions"}],"predecessor-version":[{"id":3075,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/3067\/revisions\/3075"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/3068"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=3067"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=3067"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=3067"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}