{"id":30835,"date":"2018-08-04T01:00:00","date_gmt":"2018-08-09T04:11:55","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e5%ae%83%e8%ae%a9%e4%b9%94%e5%b8%83%e6%96%af%e5%a4%9a%e6%b4%bb%e4%ba%86%e4%b8%83%e5%b9%b4%ef%bc%9f%e6%88%91%e4%bb%ac%e6%9d%a5%e8%81%8a%e8%81%8a%e5%8c%bb%e7%96%97%e9%a2%86%e5%9f%9f%e9%87%8c%e7%9a%84\/"},"modified":"2018-08-09T12:11:57","modified_gmt":"2018-08-09T04:11:57","slug":"%e5%ae%83%e8%ae%a9%e4%b9%94%e5%b8%83%e6%96%af%e5%a4%9a%e6%b4%bb%e4%ba%86%e4%b8%83%e5%b9%b4%ef%bc%9f%e6%88%91%e4%bb%ac%e6%9d%a5%e8%81%8a%e8%81%8a%e5%8c%bb%e7%96%97%e9%a2%86%e5%9f%9f%e9%87%8c%e7%9a%84","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/30835\/","title":{"rendered":"\u5b83\u8ba9\u4e54\u5e03\u65af\u591a\u6d3b\u4e86\u4e03\u5e74\uff1f\u6211\u4eec\u6765\u804a\u804a\u533b\u7597\u9886\u57df\u91cc\u7684\u524d\u6cbf\u79d1\u6280"},"content":{"rendered":"
\n

\"\u5b83\u8ba9\u4e54\u5e03\u65af\u591a\u6d3b\u4e86\u4e03\u5e74\uff1f\u6211\u4eec\u6765\u804a\u804a\u533b\u7597\u9886\u57df\u91cc\u7684\u524d\u6cbf\u79d1\u6280\"<\/p>\n

2004 \u5e74\uff0c\u4e54\u5e03\u65af\u88ab\u786e\u8bca\u60a3\u4e0a\u80f0\u5c9b\u7ec6\u80de\u7624\uff0c\u4e4b\u540e\u4ed6\u82b1\u4e86 10 \u4e07\u7f8e\u5143\u53bb\u505a\u57fa\u56e0\u68c0\u6d4b\u3002\u4e54\u5e03\u65af\u8ba4\u4e3a\u8fd9\u6837\u7684\u68c0\u6d4b\u5f88\u6709\u610f\u4e49\uff0c\u4ee5\u81f4\u4e8e\u540e\u6765\u4ed6\u5728\u63a5\u53d7\u300a\u9ebb\u7701\u7406\u5de5\u79d1\u6280\u8bc4\u8bba\u300b\u91c7\u8bbf\u65f6\u8bf4\uff1a\u300c\u6211\u8981\u4e48\u662f\u7b2c\u4e00\u6279\u4ee5\u8fd9\u79cd\u65b9\u5f0f\u51fb\u8d25\u764c\u75c7\u7684\u4eba\uff0c\u8981\u4e48\u662f\u6700\u540e\u4e00\u6279\u6b7b\u4e8e\u764c\u75c7\u7684\u4eba\u3002\u300d<\/p>\n

\u6839\u636e\u5a92\u4f53\u62a5\u9053\uff0c\u533b\u7597\u56e2\u961f\u901a\u8fc7\u57fa\u56e0\u68c0\u6d4b\u4e86\u89e3\u4e86\u4e54\u5e03\u65af\u60a3\u4e0a\u80bf\u7624\u7684\u72ec\u7279\u57fa\u56e0\u548c\u5206\u5b50\u7279\u5f81\uff0c\u968f\u540e\u4e3a\u4ed6\u9009\u62e9\u4e86\u7279\u5b9a\u7684\u836f\u7269\uff0c\u76f4\u63a5\u7834\u574f\u8ba9\u7ec6\u80de\u764c\u53d8\u7684\u5206\u5b50\u6d3b\u52a8\u3002<\/p>\n

\u4e0d\u8fc7\uff0c\u4e54\u5e03\u65af\u6700\u7ec8\u8fd8\u662f\u6ca1\u80fd\u71ac\u8fc7\u75c5\u9b54\u3002\u5728\u4ed6 2011 \u5e74\u901d\u4e16\u4e4b\u540e\uff0c\u5916\u754c\u4fbf\u6709\u8bc4\u8bba\uff0c\u8ba4\u4e3a\u6b63\u662f\u8fd9\u79cd\u57fa\u4e8e\u57fa\u56e0\u68c0\u6d4b\u7684\u80bf\u7624\u7cbe\u51c6\u8bca\u65ad\u8ba9\u4e54\u5e03\u65af\u591a\u6d3b\u4e86\u4e03\u5e74\uff0c\u53ea\u662f\u8fd9\u79cd\u8bc4\u8bba\u5c1a\u6709\u4e89\u8bae\uff0c\u56e0\u4e3a\u5176\u5b9e\u65e9\u5728 2004 \u5e74\uff0c\u4ed6\u5c31\u5728\u5bb6\u9644\u8fd1\u7684\u65af\u5766\u798f\u533b\u7597\u4e2d\u5fc3\u63a5\u53d7\u8fc7\u4e00\u6b21\u80bf\u7624\u5207\u9664\u624b\u672f\u3002<\/p>\n

2015 \u5e74\uff0c\u7f8e\u56fd\u5f71\u661f\u5b89\u5409\u4e3d\u5a1c\u00b7\u6731\u8389\u81ea\u66dd\u63a5\u53d7\u4e86\u9884\u9632\u6027\u7684\u53cc\u4e73\u623f\u5207\u9664\u624b\u672f\uff0c\u56e0\u4e3a\u57fa\u56e0\u68c0\u6d4b\u663e\u793a\u5979\u6709\u4e00\u4e2a\u7f3a\u9677\u57fa\u56e0\uff0c\u8ba9\u5979\u6709 87% \u7684\u51e0\u7387\u60a3\u4e0a\u4e73\u817a\u764c\uff0c50% \u7684\u51e0\u7387\u60a3\u4e0a\u5375\u5de2\u764c\u3002\u5f53\u7136\uff0c\u6731\u8389\u7684\u505a\u6cd5\u968f\u540e\u5728\u533b\u5b66\u754c\u4e5f\u5f15\u53d1\u4e86\u4e00\u4e9b\u4e89\u8bae\u3002<\/p>\n

\u4f46\u6ca1\u6709\u4e89\u8bae\u7684\u662f\uff0c\u540d\u4eba\u6548\u5e94\u8ba9\u80bf\u7624\u7cbe\u51c6\u8bca\u65ad\u8d8a\u6765\u8d8a\u53d7\u5173\u6ce8\uff0c\u5b83\u80fd\u5bf9\u4e2a\u4eba\u5b9e\u65bd\u4e2a\u6027\u5316\u7684\u8bca\u7597\u51b3\u7b56\u65b9\u6848\uff0c\u4ee5\u5b9e\u73b0\u6700\u4f73\u7684\u9884\u9632\u548c\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

\u533b\u5b66\u9886\u57df\u7684\u8fd9\u4e00\u53d1\u5c55\u65b9\u5411\u4e5f\u88ab\u5404\u56fd\u653f\u5e9c\u91cd\u89c6\u30022015 \u5e74\uff0c\u65f6\u4efb\u7f8e\u56fd\u603b\u7edf\u5965\u5df4\u9a6c\u5728\u56fd\u60c5\u54a8\u6587\u4e2d\u63d0\u51fa\u4e86\u300c\u7cbe\u51c6\u533b\u5b66\u8ba1\u5212\u300d\uff0c\u968f\u540e\u4e2d\u56fd\u4e5f\u63d0\u51fa\u8981\u5728 2030 \u5e74\u4e4b\u524d\uff0c\u5f80\u7cbe\u51c6\u533b\u7597\u9886\u57df\u6295\u5165 600 \u4ebf\u5143\u3002\u800c\u79ef\u6781\u6295\u8eab\u5176\u4e2d\u7684\u4f01\u4e1a\uff0c\u4e0d\u4ec5\u5305\u62ec\u8bfa\u534e\u3001\u7f57\u6c0f\u8fd9\u6837\u7684\u836f\u4f01\uff0c\u4e5f\u6709\u82f1\u7279\u5c14\u3001IBM\u3001\u963f\u91cc\u5df4\u5df4\u8fd9\u6837\u7684\u79d1\u6280\u516c\u53f8\uff0c\u66f4\u591a\u7684\u5219\u662f\u4e13\u6ce8\u4e8e\u57fa\u56e0\u68c0\u6d4b\u548c\u7cbe\u51c6\u533b\u7597\u7684\u4e13\u4e1a\u5316\u521d\u521b\u516c\u53f8\u3002<\/strong>\u5982\u4eca\uff0c\u57fa\u56e0\u6d4b\u5e8f\u4e0d\u4f46\u6210\u4e3a\u751f\u547d\u79d1\u5b66\u7814\u7a76\u7684\u5e38\u7528\u6280\u672f\uff0c\u4e5f\u6b63\u9010\u6b65\u5e94\u7528\u5230\u4eba\u7c7b\u5065\u5eb7\u9886\u57df\uff0c\u6df1\u523b\u5730\u6539\u53d8\u7740\u73b0\u6709\u7684\u4e34\u5e8a\u8bca\u65ad\u3001\u836f\u7269\u7814\u53d1\u548c\u533b\u7597\u5065\u5eb7\u6a21\u5f0f\u7b49\u3002\u8fc7\u53bb\u51e0\u5e74\uff0c\u7cbe\u51c6\u533b\u7597\u7684\u706b\u70ed\uff0c\u5438\u5f15\u4e86\u8bf8\u591a\u8d44\u672c\u7684\u6295\u5165\uff0c\u65b0\u578b\u7684\u521b\u4e1a\u516c\u53f8\u4e5f\u72b9\u5982\u96e8\u540e\u6625\u7b0b\u4e00\u822c\u4e0d\u65ad\u6d8c\u73b0\u3002\u8fd9\u4e24\u5e74\u5149\u57fa\u56e0\u6d4b\u5e8f\u7684\u670d\u52a1\u516c\u53f8\u5c31\u51fa\u73b0\u4e86\u51e0\u767e\u5bb6\uff0c\u62e5\u6709\u81ea\u5df1\u7684\u6838\u5fc3\u6280\u672f\u548c\u6838\u5fc3\u4ea7\u54c1\uff0c\u505a\u51fa\u7279\u8272\uff0c\u6b63\u5728\u6210\u4e3a\u57fa\u56e0\u68c0\u6d4b\u516c\u53f8\u8d44\u672c\u7ea2\u5229\u4e4b\u540e\uff0c\u5fc5\u987b\u76f4\u9762\u7684\u7ade\u4e89\u6001\u52bf\u3002<\/span><\/strong><\/strong><\/p>\n

\u4eca\u5929\u57fa\u56e0\u8c37\u4ece\u6280\u672f\u89d2\u5ea6\u5e26\u5927\u5bb6\u8ba4\u8bc6\u90e8\u5206\u81f4\u529b\u4e8e\u80bf\u7624\u7cbe\u51c6\u533b\u7597\u7684\u57fa\u56e0\u79d1\u6280\u516c\u53f8\uff1a<\/strong><\/p>\n

\"\u5b83\u8ba9\u4e54\u5e03\u65af\u591a\u6d3b\u4e86\u4e03\u5e74\uff1f\u6211\u4eec\u6765\u804a\u804a\u533b\u7597\u9886\u57df\u91cc\u7684\u524d\u6cbf\u79d1\u6280\"<\/p>\n

DiaCarta\uff08\u5e1d\u57fa\u751f\u7269\uff09\uff1a\u57fa\u56e0\u65f6\u4ee3\u5df2\u7ecf\u6765\u4e34<\/span>
<\/h1>\n

\u8fd1\u5e74\u6765\uff0c\u901a\u8fc7\u5206\u5b50\u8bca\u65ad\u6307\u5bfc\u60a3\u8005\u4e2a\u4f53\u5316\u7684\u7cbe\u51c6\u6cbb\u7597\u5df2\u9010\u6e10\u6210\u4e3a\u80bf\u7624\u4e34\u5e8a\u4e13\u5bb6\u7684\u5171\u8bc6\u3002\u5728\u8fd9\u6837\u7684\u80cc\u666f\u4e4b\u4e0b\uff0c\u6db2\u4f53\u6d3b\u68c0\u8fc5\u901f\u6210\u4e3a\u4e34\u5e8a\u5173\u6ce8\u7684\u7126\u70b9\u3002\u4f5c\u4e3a\u4f53\u5916\u8bca\u65ad\u7684\u4e00\u4e2a\u5206\u652f\uff0c\u6db2\u4f53\u6d3b\u68c0\u901a\u8fc7\u8840\u6db2\u6216\u8005\u5c3f\u6db2\u7b49\u5bf9\u764c\u75c7\u7b49\u75be\u75c5\u505a\u51fa\u8bca\u65ad\uff0c\u5176\u4f18\u52bf\u5728\u4e8e\u901a\u8fc7\u975e\u4fb5\u5165\u6027\u7684\u53d6\u6837\u65b9\u5f0f\u6709\u6548\u7684\u964d\u4f4e\u4e86\u6d3b\u68c0\u7684\u5371\u5bb3\u3002<\/p>\n

DiaCarta\uff08\u5e1d\u57fa\u751f\u7269\uff09\u662f\u4e16\u754c\u9886\u5148\u7684\u5206\u5b50\u8bca\u65ad\u8bd5\u5242\u3001\u6280\u672f\u5e73\u53f0\u7814\u53d1\u516c\u53f8\uff0c\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u65e7\u91d1\u5c71\uff0c\u5177\u6709\u5168\u7403\u9886\u5148\u7684\u6db2\u4f53\u6d3b\u68c0\u5206\u5b50\u8bca\u65ad\u6280\u672f\uff0c\u800c\u4e14\u5c06\u56fd\u9645\u9996\u521b\u7684 QClamp\u2122 XNA \u5206\u5b50\u5d4c\u5408\u6280\u672f\u548c\u7eb3\u7c73\u6280\u672f\u5b8c\u7f8e\u7ed3\u5408\uff0c\u5e76\u8fd0\u7528\u4e8e\u6db2\u4f53\u6d3b\u68c0\u3002\u8fd9\u4e00\u521b\u65b0\u5bf9\u4e8ectDNA\u7684\u4e34\u5e8a\u68c0\u6d4b\uff0c\u5728\u65f6\u95f4\u3001\u6210\u672c\u53ca\u7075\u654f\u5ea6\u65b9\u9762\u5747\u4f18\u4e8e\u4e8c\u4ee3\u6d4b\u5e8f\u6280\u672f\u3002<\/p>\n

2016\u5e74\uff0c\u5e1d\u57fa\u751f\u7269\u6b63\u5f0f\u7b7e\u7ea6\u843d\u6237\u5357\u4eac\u751f\u7269\u533b\u836f\u8c37\u30022017\u5e7411\u670820\u65e5\uff0cDiaCarta\uff08\u5e1d\u57fa\u751f\u7269\uff09\u5ba3\u5e03\u5b8c\u6210\u91d1\u989d\u9ad8\u8fbe3\u4ebf\u5143\u7684\u65b0\u4e00\u8f6e\u878d\u8d44\uff0c\u7528\u4e8e\u652f\u6301\u5168\u7403\u5e02\u573a\u5f00\u62d3\u3001\u91cd\u5927\u9879\u76ee\u6218\u7565\u5408\u4f5c\u3001\u65b0\u4ea7\u54c1\u5f00\u53d1\u3001FDA\u53caCFDA\u7533\u62a5\u7b49\u3002\u51ed\u501f\u5176\u5728\u5206\u5b50\u8bca\u65ad\u53ca\u57fa\u56e0\u68c0\u6d4b\u9886\u57df\u7684\u9886\u5148\u6280\u672f\uff0cDiaCarta\uff08\u5e1d\u57fa\u751f\u7269\uff09\u8fd8\u6210\u529f\u5165\u9a7b\u626c\u5b50\u56fd\u6295\u96c6\u56e2\u65d7\u4e0b\u7684\u626c\u5b50\u79d1\u521b\u4e2d\u5fc3\u2014\u2014\u5168\u7403\u6700\u5927\u9ad8\u901a\u91cf\u6d4b\u5e8f\u5e73\u53f0\u53ca\u56fd\u5bb6\u5927\u6570\u636e\u4e2d\u5fc3\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5e1d\u57fa\u751f\u7269<\/span>\u6709\u51e0\u4e2a\u6280\u672f\u5e73\u53f0\uff0c\u5176\u4e2dQClamp\u2122XNA \u5206\u5b50\u5d4c\u5408\u6280\u672f\uff0c\u5c5e\u4e8e\u56fd\u9645\u9996\u521b\uff0c\u89e3\u51b3\u4e86\u76ee\u524d\u6db2\u4f53\u6d3b\u68c0\u7684\u4e00\u4e2a\u74f6\u9888\u3002\u8be5\u6280\u672f\u901a\u8fc7Watson-Crick\u78b1\u57fa\u914d\u5bf9\u6742\u4ea4\u6765\u83b7\u5f97\u9776\u5411DNA\u5e8f\u5217\u3002\u57fa\u4e8e\u5176\u4e13\u6709\u7684\u57fa\u4e8eXNA\u7684NGS\u6587\u5e93\u5236\u5907\u6280\u672f\uff0cDiaCarta\uff08\u5e1d\u57fa\u751f\u7269\uff09\u79d1\u5b66\u5bb6\u9009\u62e9\u6027\u5730\u6269\u589e\u4f4e\u9891\u7a81\u53d8\uff0c\u5e76\u963b\u65ad\u805a\u5408\u9176\u6269\u589e \u201c\u6b63\u5e38\u201d\uff08\u91ce\u751f\u578b\uff09\u7684DNA\u3002\u8fd9\u5141\u8bb8\u6211\u4eec\u8fdb\u884c\u6700\u4f4e\u9650\u5ea6\u7684NGS\u68c0\u6d4b\u6765\u627e\u5230\u8fd9\u4e9b\u4f4e\u9891\u7a81\u53d8\uff0c\u5e76\u4e14\u53ef\u4ee5\u572848\u5c0f\u65f6\u5185\u751f\u6210\u7ed3\u679c\u3002\u4f7f\u7528\u6807\u51c6\u5206\u6790\u6d41\u7a0b\u53ef\u4ee5\u5feb\u901f\u5206\u6790\u6570\u636e\uff0c\u800c\u65e0\u9700\u5e7f\u6cdb\u7684\u751f\u7269\u4fe1\u606f\u5b66\u6765\u5904\u7406\u91ce\u751f\u578b\u7ed3\u679c\u7684\u566a\u97f3\uff0c\u8fd9\u8ba9\u68c0\u6d4b\u80bf\u7624\u4f4e\u9891\u7a81\u53d8\u7684\u53ef\u9760\u6027\u589e\u52a0\u3002\u8be5\u6280\u672f\u6709\u5229\u4e8e\u5feb\u901f\u51c6\u786e\u5730\u627e\u5230\u6709\u95ee\u9898\u7684\u7a81\u53d8DNA\uff0c\u89e3\u51b3\u4e86\u57fa\u56e0\u68c0\u6d4b\u4e2d\u975e\u7a81\u53d8DNA\u7684\u5e72\u6270\u74f6\u9888\uff0c\u6781\u5927\u5730\u63d0\u9ad8\u57fa\u56e0\u68c0\u6d4b\u7075\u654f\u5ea6\u548c\u7279\u5f02\u6027\u3002<\/p>\n

\u6cdb\u751f\u5b50\uff1a\u57fa\u56e0\u6355\u83b7\u65e0\u635f\u5931\uff0c\u7cbe\u51c6\u5feb\u4eba\u6709\u201c\u4e00\u6b65\u201d<\/span><\/h1>\n

\u5728\u5e38\u89c4\u7684NGS\u6280\u672f\u4e34\u5e8a\u5e94\u7528\u4e2d\uff0c\u7ecf\u5178\u7684\u5efa\u5e93\u6355\u83b7\u6d4b\u5e8f\u65b9\u6cd5\u4ecd\u5b58\u5728\u6b65\u9aa4\u591a\u3001\u6d41\u7a0b\u957f\u3001\u64cd\u4f5c\u7e41\u7410\u3001\u6837\u672c\u9700\u6c42\u91cf\u5927\u3001\u96be\u4ee5\u6807\u51c6\u5316\u7b49\u95ee\u9898\u3002\u4e3a\u6b64\uff0c\u6cdb\u751f\u5b50\u57fa\u56e0\u4e13\u5bb6\u56e2\u961f\u5728\u73b0\u6709\u6280\u672f\u57fa\u7840\u4e0a\uff0c\u5f00\u521b\u4e86\u201c\u4e00\u6b65\u6cd5\u201d\u5feb\u901f\u68c0\u6d4b\u6280\u672f\uff0c\u5c06\u57fa\u56e0\u6355\u83b7\u6d41\u7a0b\u7b80\u5316\u5230PCR\u6c34\u5e73\uff0c\u4eba\u5de5\u64cd\u4f5c\u53ea\u97005\u5206\u949f\uff0c1.5\u5c0f\u65f6\u4fbf\u80fd\u5b8c\u6210\u4e00\u6b65\u6cd5\u5efa\u5e93\uff0c\u4ece\u6536\u5230\u6837\u672c\u5230\u51fa\u5177\u68c0\u6d4b\u62a5\u544a\u6700\u5feb\u53ef\u4ee5\u57282\u5929\u5185\u5b8c\u6210\uff1b\u540c\u65f6\u80fd\u591f\u5927\u5927\u964d\u4f4e\u6837\u672c\u9700\u6c42\u91cf\u3001\u964d\u4f4e\u6837\u672c\u95f4\u4ea4\u53c9\u6c61\u67d3\u98ce\u9669\uff0c\u975e\u5e38\u9002\u5408\u533b\u9662\u72ec\u7acb\u5f00\u5c55\u68c0\u6d4b\u5b9e\u9a8c\u3002\u57fa\u4e8e\u201c\u4e00\u6b65\u6cd5\u201d\u6280\u672f\uff0c\u6cdb\u751f\u5b50\u63a8\u51fa\u4e86\u591a\u6b3e\u9002\u7528\u4e8e\u77f3\u8721\u5207\u7247\u3001\u7a7f\u523a\u7ec4\u7ec7\u3001\u4f53\u6db2\uff08\u8840\u6db2\uff0c\u5c3f\u6db2\uff0c\u553e\u6db2\uff0c\u8111\u810a\u6db2\u7b49\uff09\u7b49\u4e0d\u540c\u7c7b\u578b\u6807\u672c\u7684Panel\uff0c\u6d89\u53ca\u591a\u4e2a\u764c\u79cd\uff0c\u4e14\u5927\u90e8\u5206\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u68c0\u9a8c\u9636\u6bb5\u3002\u672a\u6765\u8fd8\u5c06\u5728\u7ee7\u7eed\u63a8\u51fa\u66f4\u591a\u764c\u79cdPanel\u7684\u540c\u65f6\uff0c\u8fd8\u5c06\u63a8\u51fa\u5b9a\u5236\u5316Panel\uff0c\u79ef\u6781\u63a8\u52a8\u4e34\u5e8a\u8f6c\u5316\u3002<\/p>\n

\"\u5b83\u8ba9\u4e54\u5e03\u65af\u591a\u6d3b\u4e86\u4e03\u5e74\uff1f\u6211\u4eec\u6765\u804a\u804a\u533b\u7597\u9886\u57df\u91cc\u7684\u524d\u6cbf\u79d1\u6280\"<\/p>\n


<\/p>\n

\u9488\u5bf9\u8111\u80f6\u8d28\u7624<\/span>\uff0c\u201c\u4e00\u6b65\u6cd5\u201d\u5feb\u901f\u68c0\u6d4b\u6280\u672f\u4e0d\u4ec5\u5c06ARMS\u3001\u4e00\u4ee3\u6d4b\u5e8f\u6280\u672f\u3001\u7247\u6bb5\u5206\u6790\u53ca\u7126\u78f7\u9178\u6d4b\u5e8f\u6280\u672f\u6574\u5408\u7b80\u5316\uff0c\u5927\u5927\u51cf\u5c11\u6837\u672c\u91cf\uff0c\u4e5f\u65e0\u9700\u518d\u5bf9\u7167\u767d\u7ec6\u80de\u6837\u672c\uff1b\u5e76\u4e14\u5728\u4e0d\u5f71\u54cd\u539f\u6709\u5173\u952e\u57fa\u56e0\u4f4d\u70b9\u7684\u57fa\u7840\u4e0a\u589e\u52a0\u4e86 H3K27M \u7684\u68c0\u6d4b\uff1b\u540c\u65f6\u5728\u68c0\u6d4b\u7ed3\u679c\u5224\u8bfb\u65b9\u9762\u6784\u5efa\u4e86\u81ea\u52a8\u5206\u6790\u7cfb\u7edf\uff0c\u5bf9\u201c\u4e00\u6b65\u6cd5\u201d\u68c0\u6d4b\u7ed3\u679c\u53ef\u8fdb\u884c\u81ea\u52a8\u5224\u8bfb\u3002 <\/p>\n

\u9488\u5bf9\u5c3f\u8def\u4e0a\u76ae\u80bf\u7624<\/span>\uff0c\u73b0\u6709\u7684\u5185\u7aa5\u955c\u68c0\u6d4b\u4ecd\u5b58\u5728\u75db\u82e6\u8f83\u5927\u3001\u5bf9\u7537\u6027\u60a3\u8005\u5c24\u5176\u660e\u663e\uff0c\u6613\u5f15\u53d1\u5e76\u53d1\u75c7\u7b49\u95ee\u9898\uff0c\u800c\u57fa\u4e8e\u5c3f\u6db2\u68c0\u6d4b\u7684\u5df2\u83b7\u6279\u4ea7\u54c1\u68c0\u6d4b\u7075\u654f\u5ea6\u8f83\u4f4e\u3002\u57fa\u4e8e\u201c\u4e00\u6b65\u6cd5\u201d\u6280\u672f\u6784\u5efa\u768417\u57fa\u56e0\u7684\u68c0\u6d4bPanel\uff0c\u7ecf\u8fc7\u6570\u767e\u4f8b\u6837\u672c\u6570\u636e\u9a8c\u8bc1\uff0c\u53ef\u8986\u76d6\u8180\u80f1\u764c\uff0c\u8f93\u5c3f\u7ba1\u764c\u548c\u80be\u76c2\u764c\u9274\u522b\u8840\u5c3f\u60a3\u8005\u5c3f\u8def\u4e0a\u76ae\u80bf\u7624\u7075\u654f\u5ea6\u8d85\u8fc790%\uff0c\u4f7f\u5f97\u8fd9\u4e00\u6280\u672f\u53ef\u5728\u4e0d\u8fdc\u7684\u5c06\u6765\u6709\u6548\u5730\u670d\u52a1\u4e8e\u4e34\u5e8a\uff0c\u7ed9\u66f4\u591a\u60a3\u8005\u63d0\u4f9b\u4fbf\u5229\u7684\u8bc4\u4f30\u624b\u6bb5\u3002<\/p>\n

\u9488\u5bf9\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u591a\u57fa\u56e0\u68c0\u6d4b<\/span>\uff08\u5305\u542bEGFR\u3001ALK\u3001ROS1\u3001BRAF \u7b49\u5173\u952e\u57fa\u56e0\uff09\uff0c\u4f20\u7edf\u68c0\u6d4b\u65b9\u5f0f\u6837\u54c1\u6d88\u8017\u91cf\u8fc7\u5927\u3002NCCN\u6307\u5357\u63a8\u8350\u9ad8\u901a\u91cf\u5206\u5b50\u68c0\u6d4b\uff0c\u4ee5\u964d\u4f4e\u6837\u672c\u91cf\u6d88\u8017\u3002\u57fa\u4e8e\u201c\u4e00\u6b65\u6cd5\u201d\u63a8\u51fa\u76848\u57fa\u56e0Panel\u53ef\u6781\u5927\u7a0b\u5ea6\u964d\u4f4e\u6837\u672c\u6d88\u8017\u91cf\uff0c\u8bc6\u522b\u6709\u9488\u5bf9\u6027\u9776\u5411\u6cbb\u7597\u7684\u9a71\u52a8\u57fa\u56e0\u3002\u7ecf\u8d85900\u4f8b\u7684FFPE\u6837\u672c\u9a8c\u8bc1\uff0c\u201c\u4e00\u6b65\u6cd5\u201d\u7684\u7a81\u53d8\u53ca\u878d\u5408\u68c0\u6d4b\u7ed3\u679c\u4e0eARMS\u68c0\u6d4b\u7ed3\u679c\u4e00\u81f4\u7387\u5927\u4e8e98%\u3002<\/p>\n

\u9488\u5bf9\u4e73\u817a\u764c\u80bf\u7624\u6613\u611f\u57fa\u56e0 BRCA1\/2 <\/span>\uff0c\u201c\u4e00\u6b65\u6cd5\u201d\u8fdb\u4e00\u6b65\u53d1\u6325\u4e86\u65b9\u4fbf\u5feb\u901f\u7684\u4f18\u52bf\uff1a\u4ec5\u97001mL\u553e\u6db2\uff0c8\u5206\u949f\u5185\u5373\u53ef\u5b8c\u6210\u6837\u672cDNA\u63d0\u53d6\uff1b2\u5c0f\u65f6\u5b8c\u6210\u5904\u7406\u6837\u672c\u5230\u5efa\u5e93\uff1b\u5e76\u5185\u7f6e\u6027\u522b\u548c\u8eab\u4efd\u8bc6\u522b\u4f4d\u70b9\uff0c\u9632\u6b62\u6837\u672c\u6765\u6e90\u6c61\u67d3\uff1b\u68c0\u6d4b\u4f4d\u70b9\u5305\u542b BRCA1\/2 \u6240\u6709\u5916\u663e\u5b50\u53ca\u4e24\u4fa7\u526a\u5207\u4f4d\u70b915bp\u533a\u57df\uff1b\u68c0\u6d4b\u53d8\u5f02\u7c7b\u578b\u5305\u62ecSNP\u3001INDEL\u548c\u5927\u7247\u6bb5\u7f3a\u5931\uff1b\u5168\u90e8\u6269\u589e\u5b50\u5747\u4e00\u6027\u8d85\u8fc798%\u3002<\/p>\n

\u53a6\u95e8\u827e\u5fb7\uff1a\u7814\u53d1\u201c\u8bd5\u5242\u76d2\u201d\uff0c\u8ba9\u80ba\u764c\u60a3\u8005\u770b\u5230\u66d9\u5149<\/span><\/span><\/strong><\/p>\n

2017\u5e74\u65b0\u5e74\u4f0a\u59cb\uff0c\u4e00\u6761\u65b0\u95fb\u5f15\u8d77\u533b\u836f\u9886\u57df\u4e1a\u5185\u4eba\u58eb\u7684\u5173\u6ce8\u3002<\/p>\n

\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5236\u836f\u516c\u53f8\u4e0e\u827e\u5fb7\u751f\u7269\u542f\u52a8\u80ba\u764cEGFR\u57fa\u56e0\u7a81\u53d8\u8840\u6db2\u68c0\u6d4b\u6218\u7565\u5408\u4f5c\uff0c\u8fd9\u610f\u5473\u7740\u8840\u6db2EGFR\u7a81\u53d8\u68c0\u6d4b\u8bd5\u5242\u76d2\u5c06\u5728\u56fd\u5185\u5e7f\u6cdb\u63a8\u5e7f\uff0c\u5b9e\u73b0\u4e00\u7ba1\u8840\u5373\u53ef\u68c0\u6d4bEGFR\u57fa\u56e0\u7a81\u53d8\u72b6\u6001\uff0c\u8ba9\u66f4\u591a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u6709\u673a\u4f1a\u4ece\u9776\u5411\u836f\u7269\u6cbb\u7597\u4e2d\u53d7\u76ca\u3002<\/p>\n

\u5728\u6211\u56fd\uff0c\u80ba\u764c\u4f4d\u5c45\u764c\u75c7\u53d1\u75c5\u7387\u3001\u6b7b\u4ea1\u7387\u9996\u4f4d\uff0c\u540c\u65f6\uff0c\u9488\u5bf9\u80ba\u764c\u7684\u9776\u5411\u836f\u7269\u5df2\u8fdb\u5165\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u3002\u7136\u800c\uff0c\u9776\u5411\u836f\u7269\u5374\u5e76\u975e\u5bf9\u6240\u6709\u80ba\u764c\u60a3\u8005\u90fd\u6709\u7279\u6548\uff0c\u9700\u8981\u6839\u636e\u9776\u5411\u57fa\u56e0\u53d8\u5f02\u60c5\u51b5\u8fdb\u884c\u7cbe\u51c6\u6cbb\u7597\u3002\u4e34\u5e8a\u7ed3\u679c\u663e\u793a\uff0c\u4e0d\u7ecf\u57fa\u56e0\u68c0\u6d4b\u7b5b\u9009\u4f7f\u7528\u9776\u5411\u836f\u7269\u6cbb\u7597\uff0c\u5e73\u5747\u6709\u6548\u7387\u4ec5\u4e3a30%\uff5e40%\u3002<\/p>\n

\u201c\u76f2\u8bd5\u201d\u9776\u5411\u836f\u7269\uff0c\u4e0d\u4ec5\u610f\u5473\u7740\u5c06\u6709\u8d85\u4e00\u534a\u7684\u60a3\u8005\u56e0\u201c\u836f\u4e0d\u5bf9\u75c7\u201d\u9519\u5931\u7cbe\u51c6\u6cbb\u7597\u673a\u4f1a\uff0c\u800c\u4e14\u4e5f\u4f1a\u9020\u6210\u533b\u7597\u8d44\u6e90\u6d6a\u8d39\u4ee5\u53ca\u533b\u4fdd\u57fa\u91d1\u7684\u4e0d\u5408\u7406\u4f7f\u7528\u3002<\/p>\n

\u53a6\u95e8\u827e\u5fb7\u751f\u7269\u533b\u836f\u79d1\u6280\u80a1\u4efd\u516c\u53f8\u5de5\u7a0b\u5e08\u3001\u7814\u53d1\u90e8\u7ecf\u7406\u6c5f\u98ce\u9601\u7684\u5de5\u4f5c\uff0c\u5c31\u662f\u8d1f\u8d23\u7814\u53d1\u68c0\u6d4b\u764c\u75c7\u60a3\u8005\u57fa\u56e0\u53d8\u5f02\u60c5\u51b5\u7684\u201c\u8bd5\u5242\u76d2\u201d\uff0c\u8ba9\u764c\u75c7\u60a3\u8005\u907f\u514d\u5ef6\u8bef\u6cbb\u7597\u65f6\u673a\u3002<\/p>\n

\u91cd\u590d\u4e0a\u4e07\u6b21\u52a8\u4f5c\uff0c\u53ea\u4e3a\u7cbe\u786e\u7814\u53d1<\/span><\/h1>\n<\/p>\n

\u4e00\u6ef4\u6c34\u5927\u7ea6\u76f8\u5f53\u4e8e50\u5fae\u5347\uff0c\u800c\u6c5f\u98ce\u9601\u7814\u7a76\u7684\u8bd5\u5242\u914d\u65b9\u5e38\u5e38\u7cbe\u786e\u52300.1\u5fae\u5347\uff0c\u751a\u81f3\u662f0.01\u5fae\u5347\uff0c\u6b63\u662f\u8fd9\u4e9b\u5fae\u6beb\u4e4b\u95f4\u7684\u6210\u5206\u53d8\u5316\uff0c\u64a9\u52a8\u7740\u764c\u75c7\u60a3\u8005\u7684\u795e\u7ecf\u3002<\/p>\n

\u6bcf\u4e2a\u8bd5\u5242\u677f\u4e0a\u670996\u4e2a\u5c0f\u5b54\uff0c\u6bcf\u4e2a\u5c0f\u5b54\u91cc\u90fd\u653e\u6709\u4e00\u652f\u79bb\u5fc3\u7ba1\uff0c\u8fd9\u5757\u957f\u65b9\u5f62\u7684\u8bd5\u5242\u677f\u5c31\u662f\u6c5f\u98ce\u9601\u548c\u540c\u4e8b\u4eec\u7684\u201c\u6218\u573a\u201d\u3002<\/p>\n

\u5728\u8fd9\u573a\u6ca1\u6709\u785d\u70df\u7684\u6218\u4e89\u91cc\uff0c\u4e0d\u4ec5\u9700\u8981\u6301\u4e45\u7684\u8010\u529b\uff0c\u66f4\u9700\u8981\u57cb\u4e0b\u5934\u3001\u6c89\u4e0b\u5fc3\u7684\u5b9a\u529b\u3002<\/p>\n

\u5728\u7814\u53d1\u7684\u521d\u59cb\u9636\u6bb5\uff0c\u6c5f\u98ce\u9601\u9700\u8981\u8bbe\u8ba1\u51e0\u5341\u4e2a\u68af\u5ea6\u7684\u5b9e\u9a8c\u8fdb\u884c\u7b5b\u9009\u548c\u6478\u7d22\uff0c\u800c\u6bcf\u4e00\u6b21\u8bd5\u5242\u5242\u91cf\u7684\u5fae\u8c03\uff0c\u6bcf\u4e00\u79cd\u8bd5\u5242\u6210\u5206\u7684\u53d8\u52a8\uff0c\u90fd\u610f\u5473\u7740\u6210\u500d\u589e\u52a0\u7684\u5de5\u4f5c\u91cf\u3002<\/p>\n

\u901a\u5e38\uff0c\u6bcf\u652f\u79bb\u5fc3\u7ba1\u91cc\u542b\u6709\u5341\u51e0\u79cd\u6db2\u4f53\u6210\u5206\uff0c\u8fd9\u4e9b\u6db2\u4f53\u7684\u6bd4\u4f8b\u6784\u6210\u4e86\u201c\u8bd5\u5242\u76d2\u201d\u7684\u914d\u65b9\uff0c\u800c\u8fd9\u4e9b\u6db2\u4f53\u7684\u914d\u6bd4\u5355\u4f4d\u901a\u5e38\u9700\u8981\u7cbe\u786e\u52300.01\u5fae\u5347\u3002\u68c0\u6d4b\u80ba\u764c\u57fa\u56e0\u7a81\u53d8\u7684\u201c\u8bd5\u5242\u76d2\u201d\u5c31\u662f\u5728\u7ecf\u8fc7\u4e86\u6570\u4e07\u7248\u8fd9\u6837\u7684\u5b9e\u9a8c\u548c\u5fae\u8c03\u540e\u624d\u6700\u7ec8\u83b7\u5f97\u6210\u529f\u7684\u3002<\/p>\n

\u968f\u7740\u5927\u89c4\u6a21\u751f\u7269\u6837\u672c\u6570\u636e\u5e93\u3001\u7ec4\u5b66\u3001\u5927\u6570\u636e\u7684\u53d1\u5c55\uff0c\u7cbe\u51c6\u533b\u7597\u7684\u5730\u4f4d\u5f97\u5230\u663e\u8457\u63d0\u5347\u3002\u4f5c\u4e3a\u4e00\u79cd\u4f9d\u636e\u6bcf\u4e2a\u4e2a\u4f53\u7684\u57fa\u56e0\u3001\u5065\u5eb7\u5dee\u5f02\u6765\u5236\u5b9a\u4e2a\u6027\u5316\u6cbb\u7597\u548c\u9884\u9632\u65b9\u6848\u7684\u65b0\u578b\u6cbb\u7597\u65b9\u6cd5\uff0c\u7cbe\u51c6\u533b\u7597\u6216\u8bb8\u53ef\u4ee5\u5f15\u9886\u65b0\u7684\u533b\u5b66\u65f6\u4ee3\u3002\u57fa\u56e0\u8c37\u4e5f\u5c06\u6301\u7eed\u5c55\u73b0\u66f4\u591a\u4e1a\u5185\u4f01\u4e1a\u7684\u6280\u672f\u98ce\u91c7\u3002<\/span><\/span><\/span><\/strong>
<\/p>\n

\"\u5b83\u8ba9\u4e54\u5e03\u65af\u591a\u6d3b\u4e86\u4e03\u5e74\uff1f\u6211\u4eec\u6765\u804a\u804a\u533b\u7597\u9886\u57df\u91cc\u7684\u524d\u6cbf\u79d1\u6280\"<\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u57fa\u56e0\u8c37 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

2004 \u5e74\uff0c\u4e54\u5e03\u65af\u88ab\u786e\u8bca\u60a3\u4e0a\u80f0\u5c9b\u7ec6\u80de\u7624\uff0c\u4e4b\u540e\u4ed6\u82b1\u4e86 10 \u4e07\u7f8e\u5143\u53bb\u505a\u57fa\u56e0\u68c0\u6d4b\u3002\u4e54\u5e03\u65af\u8ba4\u4e3a\u8fd9\u6837\u7684\u68c0\u6d4b\u5f88\u6709\u610f\u4e49\uff0c […]<\/p>\n","protected":false},"author":1,"featured_media":30836,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30835"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=30835"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30835\/revisions"}],"predecessor-version":[{"id":30846,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/30835\/revisions\/30846"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/30836"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=30835"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=30835"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=30835"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}