{"id":31086,"date":"2018-07-31T01:00:00","date_gmt":"2018-08-09T04:13:25","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e8%82%bf%e7%98%a4%e6%82%a3%e8%80%85%e7%9a%84%e8%ba%ab%e4%bd%93%e8%b4%a8%e9%87%8f%e6%8c%87%e6%95%b0%e4%b8%8e%e5%9f%ba%e5%9b%a0%e7%bb%84dna%e7%94%b2%e5%9f%ba%e5%8c%96%e7%9a%84%e5%85%b3%e8%81%94\/"},"modified":"2018-08-09T12:13:28","modified_gmt":"2018-08-09T04:13:28","slug":"%e8%82%bf%e7%98%a4%e6%82%a3%e8%80%85%e7%9a%84%e8%ba%ab%e4%bd%93%e8%b4%a8%e9%87%8f%e6%8c%87%e6%95%b0%e4%b8%8e%e5%9f%ba%e5%9b%a0%e7%bb%84dna%e7%94%b2%e5%9f%ba%e5%8c%96%e7%9a%84%e5%85%b3%e8%81%94","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/31086\/","title":{"rendered":"\u80bf\u7624\u60a3\u8005\u7684\u8eab\u4f53\u8d28\u91cf\u6307\u6570\u4e0e\u57fa\u56e0\u7ec4DNA\u7532\u57fa\u5316\u7684\u5173\u8054\u7814\u7a76\u83b7\u8fdb\u5c55"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533788006.jpeg\" alt=\"\u80bf\u7624\u60a3\u8005\u7684\u8eab\u4f53\u8d28\u91cf\u6307\u6570\u4e0e\u57fa\u56e0\u7ec4DNA\u7532\u57fa\u5316\u7684\u5173\u8054\u7814\u7a76\u83b7\u8fdb\u5c55\" title=\"\u80bf\u7624\u60a3\u8005\u7684\u8eab\u4f53\u8d28\u91cf\u6307\u6570\u4e0e\u57fa\u56e0\u7ec4DNA\u7532\u57fa\u5316\u7684\u5173\u8054\u7814\u7a76\u83b7\u8fdb\u5c55\"  \/><\/p>\n<p style=\"\"><span style=\"font-size: 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alt=\"\u80bf\u7624\u60a3\u8005\u7684\u8eab\u4f53\u8d28\u91cf\u6307\u6570\u4e0e\u57fa\u56e0\u7ec4DNA\u7532\u57fa\u5316\u7684\u5173\u8054\u7814\u7a76\u83b7\u8fdb\u5c55\" title=\"\u80bf\u7624\u60a3\u8005\u7684\u8eab\u4f53\u8d28\u91cf\u6307\u6570\u4e0e\u57fa\u56e0\u7ec4DNA\u7532\u57fa\u5316\u7684\u5173\u8054\u7814\u7a76\u83b7\u8fdb\u5c55\"  \/><\/p>\n<p style=\"\"><span style=\"font-size: 16px;\">\u3000\u3000\u80a5\u80d6\u5df2\u88ab\u786e\u8ba4\u4e3a\u80bf\u7624\u75be\u75c5\u7684\u98ce\u9669\u56e0\u7d20\u4e4b\u4e00\uff0c\u8eab\u4f53\u8d28\u91cf\u6307\u6570(BMI)\u662f\u4e00\u4e2a\u5e7f\u6cdb\u5e94\u7528\u7684\u8bc4\u4f30\u80a5\u80d6\u7684\u6307\u6807\u3002\u9ad8\u6c34\u5e73BMI\uff0c\u6307BMI\u6570\u503c\u5927\u4e8e25 kg\/m2\uff0c\u5305\u62ec\u8fc7\u91cd\u548c\u80a5\u80d6\uff0c\u5bf9\u591a\u79cd\u7c7b\u578b\u7684\u80bf\u7624\u7684\u53d1\u75c5\u548c\u6b7b\u4ea1\u90fd\u53d1\u6325\u7740\u91cd\u8981\u7684\u4f5c\u7528\u3002\u5f53\u524d\uff0c\u9ad8\u6c34\u5e73BMI\u7684\u53d1\u75c5\u7387\u9010\u5e74\u4e0a\u5347\uff0c\u968f\u4e4b\uff0c\u80bf\u7624\u7684\u53d1\u75c5\u7387\u4e5f\u5927\u91cf\u4e0a\u5347\u3002\u7814\u7a76\u7ed3\u679c\u5df2\u7ecf\u8868\u660e\uff1a\u5728\u8840\u6db2\u548c\u80a5\u80d6\u7ec4\u7ec7\u4e2d\uff0c\u4ee3\u8c22\u76f8\u5173\u57fa\u56e0\u7684DNA\u7532\u57fa\u5316\u6c34\u5e73\u4f1a\u56e0\u80a5\u80d6\u56e0\u7d20\u800c\u53d1\u751f\u6539\u53d8\u3002\u7136\u800c\uff0c\u5728\u80bf\u7624\u60a3\u8005\u4e2d\uff0cDNA\u7532\u57fa\u5316\u6c34\u5e73\u4e0eBMI\u7684\u5173\u7cfb\u5c1a\u672a\u6e05\u695a\u3002<\/span><\/p>\n<p style=\"\"><span style=\"font-size: 16px;\">\u3000\u3000\u4e2d\u56fd\u79d1\u5b66\u9662\u82cf\u5dde\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u6280\u672f\u7814\u7a76\u6240\u533b\u5b66\u68c0\u9a8c\u6280\u672f\u7814\u7a76\u5ba4\u9ad8\u5c71\u8bfe\u9898\u7ec4\u8054\u5408\u519b\u4e8b\u79d1\u5b66\u9662\u6559\u6388\u53f6\u742a\u6d53\u4f7f\u7528\u764c\u75c7\u57fa\u56e0\u7ec4\u8ba1\u5212\uff08The Cancer Genome Atlas\uff0cTCGA\uff09\u6570\u636e\u5e93\u768415\u79cd\u80bf\u7624\u7684\u7532\u57fa\u5316\u82af\u7247\u4e0e\u76f8\u5e94\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u5c06BMI\u7b49\u4e8e25 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pathway\u7b49\u751f\u7269\u901a\u8def\u3002\u7814\u7a76\u4eba\u5458\u8fdb\u4e00\u6b65\u5c06BMI\u4f5c\u4e3a\u8fde\u7eed\u53d8\u91cf\uff0c\u4f7f\u7528\u4e00\u822c\u7ebf\u6027\u56de\u5f52\u6a21\u578b\u5bf9\u7532\u57fa\u5316\u4f4d\u70b9\u548cBMI\u503c\u8fdb\u884c\u5173\u8054\u5206\u6790\uff0c\u540c\u6837\u53d1\u73b0\u809d\u5916\u80c6\u7ba1\u764c\u3001\u7ed3\u80a0\u764c\u3001\u5b50\u5bab\u5185\u819c\u764c\u5177\u6709\u4e0eBMI\u5b58\u5728\u7ebf\u6027\u76f8\u5173\u7684\u7532\u57fa\u5316\u4f4d\u70b9\u3002\u5e76\u4e14\uff0c\u5728\u5b50\u5bab\u5185\u819c\u764c\u4e2d\uff0c\u4e0eBMI\u7ebf\u6027\u76f8\u5173\u7684\u56db\u4e2a\u7532\u57fa\u5316\u4f4d\u70b9\uff0ccg12645852\u3001cg09621472\u3001cg27131667\u548ccg14044785\u90fd\u968f\u7740\u8be5\u80bf\u7624\u7684\u6076\u5316\u7a0b\u5ea6\u52a0\u6df1\u800c\u7532\u57fa\u5316\u6c34\u5e73\u9010\u6b65\u5347\u9ad8\uff0c\u9ad8\u6c34\u5e73\u7684cg09621472\u3001cg27131667\u548ccg14044785\u5bf9\u5b50\u5bab\u5185\u819c\u764c\u5177\u6709\u8f83\u5dee\u7684\u9884\u540e\u6548\u679c\uff0c\u8868\u660e\u5176\u6709\u671b\u6210\u4e3a\u5b50\u5bab\u5185\u819c\u764c\u6f5c\u5728\u7684\u9884\u540e\u6807\u5fd7\u7269\u3002<\/span><\/p>\n<p style=\"\"><span style=\"font-size: 16px;\">\u3000\u3000\u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u63a2\u8ba8\u4e86\u4e0eBMI\u56e0\u7d20\u76f8\u5173\u7684DNA\u7532\u57fa\u5316\u6539\u53d8\u5bf9\u80bf\u7624\u6240\u53d1\u6325\u7684\u4f5c\u7528\uff0c\u4ee5\u671f\u4e3a\u80a5\u80d6\u80bf\u7624\u4e2a\u4f53\u7684\u4e2a\u6027\u5316\u6cbb\u7597\u63d0\u4f9b\u7406\u8bba\u6307\u5bfc\u3002\u8be5\u7814\u7a76\u5de5\u4f5c\u7684\u610f\u4e49\u4e0d\u4ec5\u4ec5\u5728\u4e8e\u53d1\u73b0\u4e86\u56db\u4e2a\u6f5c\u5728\u7684\u53ef\u7528\u4e8e\u5b50\u5bab\u5185\u819c\u764c\u9884\u540e\u8bca\u65ad\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5e76\u63ed\u793a\u4e86BMI\u7684\u6539\u53d8\u53ef\u80fd\u901a\u8fc7\u5f71\u54cdDNA\u7532\u57fa\u5316\u7684\u6c34\u5e73\u800c\u4ecb\u5bfc\u80bf\u7624\u7684\u53d1\u751f\u3002\u76f8\u5173\u6210\u679c\u53d1\u8868\u5728Journal of Cancer\u4e0a\u3002<\/span><\/p>\n<p style=\"\"><span style=\"font-size: 16px;\">\u3000\u3000\u6b64\u5916\uff0c\u76f8\u5173\u6210\u679c\u5df2\u7533\u8bf7\u4e13\u5229\uff1a\u4e00\u79cd\u4eba\u80bf\u7624\u76f8\u5173\u7684\u7532\u57fa\u5316\u4f4d\u70b9\u53ca\u5176\u7b5b\u9009\u65b9\u6cd5\u548c\u7528\u9014\u3002\u4e13\u5229\u7533\u8bf7\u53f7\uff1a201710509801.4\uff0c\u76ee\u524d\u7533\u8bf7\u5df2\u516c\u5f00\u3002\u57fa\u4e8ecg12645852\u3001cg09621472\u3001cg27131667\u548ccg14044785\u7684\u7532\u57fa\u5316\u6c34\u5e73\u5bf9\u5b50\u5bab\u5185\u819c\u764c\u7684\u8fdb\u5c55\u7a0b\u5ea6\u4e0e\u751f\u5b58\u72b6\u6001\u8fdb\u884c\u9884\u540e\u8bca\u65ad\uff0c\u5176\u5e94\u7528\u80fd\u663e\u8457\u63d0\u9ad8\u5b50\u5bab\u5185\u819c\u764c\u8bca\u65ad\u7684\u7cbe\u51c6\u5ea6\uff0c\u964d\u4f4e\u5b50\u5bab\u5185\u819c\u764c\u7684\u8bca\u6cbb\u8d39\u7528\u3002<\/span><\/p>\n<p style=\"\"><span style=\"font-size: 16px;\">\u3000\u3000\u8be5\u7814\u7a76\u5de5\u4f5c\u83b7\u5f97\u4e86\u4e2d\u79d1\u9662\u767e\u4eba\u8ba1\u5212\u3001\u4e2d\u79d1\u9662\u524d\u6cbf\u79d1\u5b66\u91cd\u70b9\u7814\u7a76\u9879\u76ee\u3001\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u548c\u56fd\u5bb6\u81ea\u7136\u57fa\u91d1\u7684\u8d44\u52a9\u3002<\/span><\/p>\n<p style=\"\"><span style=\"font-size: 16px;\">\u3000\u3000\u8bba\u6587\u4fe1\u606f\uff1aYinmin Gu, Catherine Wei-Hong Zhang, Liang Wang, Yuhui Zhao, Hui Wang, Qinong Ye*, Shan Gao*. Association Analysis Between Body Mass Index And Genomic DNA Methylation Across 15 Major Cancer Types. Journal of Cancer 2018; 9(14):2532-2542. doi: 10.7150\/jca.23535.<\/span><\/p>\n<p style=\"\"><img class=\"\"     style=\"border-width: 0px;border-style: none;border-color: initial;vertical-align: top;max-width: 500px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress4-1533788006.jpeg\" alt=\"\u80bf\u7624\u60a3\u8005\u7684\u8eab\u4f53\u8d28\u91cf\u6307\u6570\u4e0e\u57fa\u56e0\u7ec4DNA\u7532\u57fa\u5316\u7684\u5173\u8054\u7814\u7a76\u83b7\u8fdb\u5c55\" title=\"\u80bf\u7624\u60a3\u8005\u7684\u8eab\u4f53\u8d28\u91cf\u6307\u6570\u4e0e\u57fa\u56e0\u7ec4DNA\u7532\u57fa\u5316\u7684\u5173\u8054\u7814\u7a76\u83b7\u8fdb\u5c55\"  \/><\/p>\n<p style=\"\"><span style=\"font-size: 16px;\">\u56fe1 \u7ed3\u80a0\u764c(a)\u4e0e\u5b50\u5bab\u5185\u819c\u764c(b)\u4e2d\uff0c\u4e0e\u9ad8BMI\u76f8\u5173\u7684\u5dee\u5f02\u7532\u57fa\u5316\u4f4d\u70b9\u6240\u5728\u57fa\u56e0\u53c2\u4e0e\u7684\u751f\u7269\u901a\u8def\u3002<\/span><\/p>\n<p style=\"\"><img class=\"\"     style=\"border-width: 0px;border-style: none;border-color: initial;vertical-align: top;max-width: 500px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533788007.jpeg\" alt=\"\u80bf\u7624\u60a3\u8005\u7684\u8eab\u4f53\u8d28\u91cf\u6307\u6570\u4e0e\u57fa\u56e0\u7ec4DNA\u7532\u57fa\u5316\u7684\u5173\u8054\u7814\u7a76\u83b7\u8fdb\u5c55\" title=\"\u80bf\u7624\u60a3\u8005\u7684\u8eab\u4f53\u8d28\u91cf\u6307\u6570\u4e0e\u57fa\u56e0\u7ec4DNA\u7532\u57fa\u5316\u7684\u5173\u8054\u7814\u7a76\u83b7\u8fdb\u5c55\"  \/><\/p>\n<p style=\"\"><span style=\"font-size: 16px;\">\u56fe2 \u5b50\u5bab\u5185\u819c\u764c\u4e2d\uff0c\u4e0eBMI\u7ebf\u6027\u76f8\u5173\u7684\u7532\u57fa\u5316\u4f4d\u70b9\u6240\u5728\u7684\u57fa\u56e0\u4e0e\u6240\u5728\u7684\u57fa\u56e0\u7ec4\u4f4d\u7f6e\u3002<\/span><\/p>\n<p style=\"\">\n<p style=\"\"><span style=\"font-size: 16px;\">\u3000\u3000\u56fe3 \u4e0eBMI\u7ebf\u6027\u76f8\u5173\u7684\u7532\u57fa\u5316\u4f4d\u70b9\u5728\u809d\u5916\u80c6\u7ba1\u764c\u3001\u7ed3\u80a0\u764c\u3001\u5b50\u5bab\u5185\u819c\u764c\u4e2d\u7684\u751f\u5b58\u5206\u6790(a)\u548c\u80bf\u7624\u8fdb\u5c55(b)\u7684\u7532\u57fa\u5316\u6c34\u5e73\u6bd4\u8f83\u3002<\/span><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress1-1533788007.jpeg\" alt=\"\u80bf\u7624\u60a3\u8005\u7684\u8eab\u4f53\u8d28\u91cf\u6307\u6570\u4e0e\u57fa\u56e0\u7ec4DNA\u7532\u57fa\u5316\u7684\u5173\u8054\u7814\u7a76\u83b7\u8fdb\u5c55\" title=\"\u80bf\u7624\u60a3\u8005\u7684\u8eab\u4f53\u8d28\u91cf\u6307\u6570\u4e0e\u57fa\u56e0\u7ec4DNA\u7532\u57fa\u5316\u7684\u5173\u8054\u7814\u7a76\u83b7\u8fdb\u5c55\"  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u57fa\u56e0\u8c37                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>DNA\u7532\u57fa\u5316\u662f\u4e00\u79cd\u4e0d\u6539\u53d8DNA\u5e8f\u5217\u800c\u5316\u5b66\u4fee\u9970DNA\u7684\u8868\u89c2\u9057\u4f20\u673a\u5236\uff0c\u53c2\u4e0e\u80bf\u7624\u7684\u53d1\u751f\u548c\u53d1\u5c55\uff0c\u53ef\u4f5c\u4e3a\u80bf\u7624\u7684\u65e9\u671f\u7b5b\u67e5\u3001 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":31087,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/31086"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=31086"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/31086\/revisions"}],"predecessor-version":[{"id":31097,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/31086\/revisions\/31097"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/31087"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=31086"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=31086"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=31086"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}