{"id":31317,"date":"2018-08-08T01:00:00","date_gmt":"2018-08-09T04:15:23","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/nature%e5%ad%90%e5%88%8a%e9%a2%81%e5%b8%83car-t%e7%96%97%e6%b3%95%e6%8c%87%e5%8d%97%ef%bc%81%e5%85%b3%e8%81%94%e5%84%bf%e7%ab%a5%e6%80%a5%e6%80%a7%e6%b7%8b%e5%b7%b4%e7%bb%86%e8%83%9e%e7%99%bd%e8%a1%80\/"},"modified":"2018-08-09T12:15:26","modified_gmt":"2018-08-09T04:15:26","slug":"nature%e5%ad%90%e5%88%8a%e9%a2%81%e5%b8%83car-t%e7%96%97%e6%b3%95%e6%8c%87%e5%8d%97%ef%bc%81%e5%85%b3%e8%81%94%e5%84%bf%e7%ab%a5%e6%80%a5%e6%80%a7%e6%b7%8b%e5%b7%b4%e7%bb%86%e8%83%9e%e7%99%bd%e8%a1%80","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/31317\/","title":{"rendered":"Nature\u5b50\u520a\u9881\u5e03CAR-T\u7597\u6cd5\u6307\u5357\uff01\u5173\u8054\u513f\u7ae5\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"xmteditor\" style=\"display:none;\"  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255);border-color: rgb(197, 63, 70);word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span class=\"\" style=\"padding: 0.3em 0.5em;max-width: 100%;box-sizing: border-box;display: inline-block;border-radius: 0px 0.5em 0.5em 0px;font-size: 1em;font-family: inherit;background-color: rgb(197, 63, 70);word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u751f\u7269\u63a2\u7d22<\/section>\n<p><\/span><\/p>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;width: 0px;border-right: 4px solid rgb(197, 63, 70);border-top: 4px solid rgb(197, 63, 70);word-wrap: break-word !important;overflow-wrap: break-word !important;border-left: 4px solid transparent !important;border-bottom: 4px solid transparent !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: 27.2656px;padding-right: 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break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u53bb\u5e748\u6708\uff0cFDA\u6279\u51c6CAR-T\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u3002\u4e00\u5e74\u540e\uff0c\u5fb7\u514b\u8428\u65af\u5927\u5b66MD Anderson\u764c\u75c7\u4e2d\u5fc3\u8054\u5408\u513f\u79d1\u6025\u6027\u80ba\u635f\u4f24\u548c\u8113\u6bd2\u75c7\u7814\u7a76\u8005\u7f51\u7edc\uff08PALISI<span style=\"color: rgb(52, 54, 60);\">\uff09<\/span>\u7684\u79d1\u5b66\u5bb6\u4eec\u53d1\u5e03\u4e86\u5173\u4e8e\u513f\u7ae5\u63a5\u53d7CAR-T\u7ec6\u80de\u6cbb\u7597\u7684\u5168\u9762\u5171\u8bc6\u6307\u5357\u3002\u6307\u5357\u6c47\u96c6\u9876\u7ea7\u4e13\u5bb6\u5728\u8bc6\u522b\u6cbb\u7597\u76f8\u5173\u6bd2\u6027\u7684\u65e9\u671f\u8ff9\u8c61\u548c\u75c7\u72b6\u65b9\u9762\u5438\u53d6\u7684\u7ecf\u9a8c\u6559\u8bad\uff0c\u5e76\u8be6\u7ec6\u4ecb\u7ecd\u4e86\u5e94\u5bf9\u8fd9\u4e9b\u75c7\u72b6\u7684\u65b9\u6cd5\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/fieldset>\n<\/section>\n<p style=\"text-align: center;\"><img class=\"\"     style=\"margin-top: 6px;margin-bottom: 6px;border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533788124.png\" alt=\"Nature\u5b50\u520a\u9881\u5e03CAR-T\u7597\u6cd5\u6307\u5357\uff01\u5173\u8054\u513f\u7ae5\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\" title=\"Nature\u5b50\u520a\u9881\u5e03CAR-T\u7597\u6cd5\u6307\u5357\uff01\u5173\u8054\u513f\u7ae5\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\"><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\">8\u67086\u65e5\uff0c\u300aNature Reviews Clinical Oncology\u300b\u6742\u5fd7\u4ee5\u201cManagement guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy\u201d\u4e3a\u9898\u5728\u7ebf\u53d1\u8868\u4e86\u8fd9\u4e00\u6307\u5357\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\">\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5(acute lymphoblastic leukemia\uff0cALL)\u662f\u4e00\u79cd\u8d77\u6e90\u4e8eB\u7cfb\u6216T\u7cfb\u6dcb\u5df4\u7956\u7ec6\u80de\u7684\u80bf\u7624\u6027\u75be\u75c5\uff0c\u539f\u59cb\u7ec6\u80de\u5728\u9aa8\u9ad3\u5f02\u5e38\u589e\u751f\u548c\u805a\u96c6\u5e76\u6291\u5236\u6b63\u5e38\u9020\u8840\uff0c\u5bfc\u81f4\u8d2b\u8840\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff1b\u539f\u59cb\u7ec6\u80de\u4e5f\u53ef\u4fb5\u53ca\u9ad3\u5916\u7ec4\u7ec7\uff0c\u5982\u8111\u819c\u3001\u6027\u817a\uff0c\u80f8\u817a\u3001\u809d\u3001\u813e\uff0c\u6216\u6dcb\u5df4\u7ed3\u7b49\uff0c\u5f15\u8d77\u76f8\u5e94\u75c5\u53d8\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\">CAR-T\u7597\u6cd5\u662f\u5728\u63d0\u53d6\u60a3\u8005\u7684T\u7ec6\u80de\u540e\uff0c\u901a\u8fc7\u57fa\u56e0\u6539\u9020\uff0c\u5c06\u4e00\u79cd\u7279\u5b9a\u86cb\u767d\uff08\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff0c\u5373CAR\uff09\u88c5\u5165T\u7ec6\u80de\u3002\u7ecf\u8fc7\u6539\u9020\u7684T\u7ec6\u80de\u91cd\u65b0\u6ce8\u5165\u4eba\u4f53\u540e\uff0c\u80fd\u591f\u7279\u5f02\u6027\u8bc6\u522b\u767d\u8840\u75c5\u7ec6\u80de\u8868\u9762\u7684\u6297\u539f\uff08CD19\uff09\uff0c\u5e76\u5c06\u5176\u6740\u6b7b\u3002\u6570\u636e\u663e\u793a\uff0c\u7ecf\u8fc7CAR-T\u4e34\u5e8a\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u540eALL\u60a3\u8005\u7684\u6210\u529f\u7387\u8fbe\u523090%\u3002\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u7684\u7814\u7a76\u65e8\u5728\u6269\u5927\u8be5\u7597\u6cd5\u5728\u5176\u4ed6\u764c\u75c7\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"     style=\"margin-top: 6px;margin-bottom: 6px;border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533788124-1.jpeg\" alt=\"Nature\u5b50\u520a\u9881\u5e03CAR-T\u7597\u6cd5\u6307\u5357\uff01\u5173\u8054\u513f\u7ae5\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\" title=\"Nature\u5b50\u520a\u9881\u5e03CAR-T\u7597\u6cd5\u6307\u5357\uff01\u5173\u8054\u513f\u7ae5\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\"><\/p>\n<p style=\"white-space: normal;text-align: center;\"><span style=\"color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1aCC0 Creative Commons<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\">\u5c3d\u7ba1CAR-T\u7597\u6cd5\u5df2\u7ecf\u663e\u793a\u51fa\u5de8\u5927\u7684\u5e0c\u671b\uff0c\u7136\u800c\u6700\u65b0\u6307\u5357\u901a\u8baf\u4f5c\u8005\u3001MD Anderson\u513f\u79d1\u526f\u6559\u6388Kris 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justify;\">Mahadeo\u8865\u5145\u9053\uff0c\u968f\u7740CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u5e94\u7528\u8d8a\u6765\u8d8a\u5e7f\u6cdb\uff0c\u6cbb\u7597\u6307\u5357\u3001\u591a\u5b66\u79d1\u4eba\u5458\u7684\u7efc\u5408\u57f9\u8bad\u4ee5\u53ca\u5176\u4ed6\u63aa\u65bd\u5e94\u8be5\u6709\u52a9\u4e8e\u5bf9\u8fd9\u79cd\u65b0\u7597\u6cd5\u53ef\u80fd\u4ea7\u751f\u7684\u6bd2\u6027\u8fdb\u884c\u9002\u5f53\u7684\u7ba1\u7406\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\">\u4e3a\u6b64\uff0cMD Anderson\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\u76f8\u5173\u6bd2\u6027 ( CARTOX )\u9879\u76ee\u4e0ePALISI\u53ca\u5176\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d( HSCT )\u5c0f\u7ec4\u5408\u4f5c\uff0c\u4e3a\u63a5\u53d7CAR-T\u7ec6\u80de\u6cbb\u7597\u7684\u513f\u7ae5\u5236\u5b9a\u4e86\u7efc\u5408\u6307\u5357\u3002\u8be5\u6307\u5357\u6c47\u96c6\u4e86\u4f17\u591a\u9886\u57df\u7684\u4e13\u5bb6\uff0c\u5305\u62ec\u513f\u79d1\u91cd\u75c7\u76d1\u62a4\u5e08\u3001\u836f\u5b66\u4e13\u5bb6\u3001\u795e\u7ecf\u5b66\u4e13\u5bb6\u548c\u8f6c\u5316\u514d\u75ab\u7597\u6cd5\u7814\u7a76\u4e13\u5bb6\uff0c\u63d0\u4f9b\u4e86\u91cd\u8981\u77e5\u8bc6\uff0c\u65e8\u5728\u5e2e\u52a9\u6539\u5584\u60a3\u8005\u7684\u4f53\u9a8c\u548c\u7ed3\u679c\u3002<\/p>\n<p><br  \/><\/p>\n<p><strong>\u4ee5\u4e0b\u662f\u6307\u5357\u90e8\u5206\u5185\u5bb9\uff1a<\/strong><\/p>\n<p><strong><br  \/><\/strong><\/p>\n<p><strong><\/strong><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">(1)\t\u5f53\u98ce\u9669\u8bc4\u4f30\u548c\u7f13\u89e3\u7b56\u7565\uff08REMS\uff09\u9879\u76ee\u83b7\u5f97FDA\u6279\u51c6\u65f6\uff0c\u5efa\u8bae\u4f9b\u5e94\u5546\u9075\u5b88\u4ea7\u54c1\u4fe1\u606f\u6807\u7b7e\u548c\u6307\u5357\uff1b<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">(2) \u5efa\u8bae\u60a3\u8005\u7684\u9009\u62e9\u5e94\u57fa\u4e8eFDA\u6279\u51c6\u7684\u9002\u5e94\u75c7\u548c\u5173\u952e\u7814\u7a76\u4e2d\u4f7f\u7528\u7684\u6807\u51c6\uff0c\u5e76\u4e14\u53ef\u6839\u636e\u6bcf\u4e2a\u65b0\u4ea7\u54c1\u7684\u65b0\u4fe1\u606f\u8fdb\u884c\u5b9a\u5236\uff1b<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">(3)\t\u540c\u610f\u5e94\u5305\u62ec\u4e0e\u767d\u8840\u75c5\u3001\u6dcb\u5df4\u8870\u7aed\u3001\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\u3001CAR-T\u7ec6\u80de\u76f8\u5173\u6027\u8111\u75c5\u7efc\u5408\u5f81\uff08CRES\uff09\u3001\u6865\u63a5\u5316\u7597\u3001\u91cd\u75c7\u76d1\u62a4\u652f\u6301(\u673a\u68b0\u901a\u6c14\u3001\u900f\u6790\u548c\u808c\u529b\u652f\u6301)\u548c\u6297\u767d\u7ec6\u80de\u4ecb\u7d20- 6\uff08anti-IL-6 \uff09\u6cbb\u7597\u76f8\u5173\u7684\u98ce\u9669\u548c\u76ca\u5904\u7684\u63cf\u8ff0\uff1b<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">(4)\t\u5728\u9002\u5f53\u60c5\u51b5\u4e0b\uff0c\u5efa\u8bae\u5f81\u6c42\u513f\u7ae5\u7684\u610f\u89c1\uff1b\u5e94\u8003\u8651\u9002\u5e94\u5e74\u9f84\u7684\u9884\u5148\u6307\u793a\uff0c\u5c06\u513f\u7ae5\u751f\u6d3b\u548c\u5fc3\u7406\u670d\u52a1\u7eb3\u5165\u8ba8\u8bba\u53ef\u80fd\u4f1a\u6709\u6240\u5e2e\u52a9\uff1b<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">(5)\t\u513f\u79d1\u60a3\u8005\u53ef\u80fd\u9700\u8981\u767d\u7ec6\u80de\u5206\u79bb\u5bfc\u7ba1\u6765\u6536\u96c6\u7ec6\u80de\u3002\u5728\u513f\u79d1\u767d\u7ec6\u80de\u5206\u79bb\u672f\u4e2d\uff0c\u5efa\u8bae\u5bc6\u5207\u76d1\u6d4b\u4f4e\u8840\u538b\u3001\u4f4e\u9499\u8840\u75c7\u548c\u5bfc\u7ba1\u76f8\u5173\u75bc\u75db\uff0c\u5c24\u5176\u662f\u5728\u65e0\u6cd5\u63cf\u8ff0\u75c7\u72b6\u7684\u5a74\u513f\u548c\u5e7c\u7ae5\u4e2d\uff1b<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">(6)\t\u5efa\u8bae\u9009\u62e9\u73af\u78f7\u9170\u80fa-\u6c1f\u8fbe\u62c9\u6ee8\uff08cyclophosphamide\u2013fludarabine\uff09\u65b9\u6848\u6cbb\u7597\u6dcb\u5df4\u8870\u7aed\uff0c\u4f46\u51fa\u8840\u6027\u8180\u80f1\u708e\u548c\/\u6216\u4ee5\u524d\u5bf9\u73af\u78f7\u9170\u80fa\u65b9\u6848\u4ea7\u751f\u8010\u836f\u6027\u7684\u9664\u5916\uff1b<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">(7)\t\u8003\u8651\u5230\u5feb\u901f\u4e34\u5e8a\u6076\u5316\u7684\u53ef\u80fd\u6027\uff0c\u5982\u679cCAR-T\u7ec6\u80de\u6cbb\u7597\u662f\u5728\u95e8\u8bca\u73af\u5883\u4e0b\u8fdb\u884c\u7684\uff0c\u90a3\u4e48\u5728\u51fa\u73b0\u53d1\u70e7\u548c\/\u6216\u6697\u793aCRS\u548c\/\u6216CRES\u7684\u75c7\u72b6\u65f6\uff0c\u5efa\u8bae\u4e3a\u60a3\u8005\u8bbe\u7f6e\u4e00\u4e2a\u8f83\u4f4e\u7684\u5165\u9662\u95e8\u69db\uff1b<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">(8)\t\u6839\u636e\u5df2\u53d1\u8868\u7684CD19+\u590d\u53d1\u548c\/\u6216\u96be\u6cbb\u6027B\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u7684\u513f\u79d1\u548c\u5e74\u8f7b\u6210\u4eba\u60a3\u8005\u7684CAR-T\u836f\u7269tisagenelecleucel\u7684\u7ecf\u9a8c\uff0c\u5efa\u8bae\u5728\u8f93\u6ce8\u540e\u4f4f\u9662\u81f3\u5c113-7\u5929\uff1b<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">(9)\t\u968f\u7740\u4e34\u5e8a\u72b6\u6001\u7684\u53d8\u5316\uff0c\u5efa\u8bae\u6bcf12\u5c0f\u65f6\u6216\u66f4\u9891\u7e41\u5730\u6267\u884cCRS\u548cCAR T\u7ec6\u80de\u76f8\u5173\u8111\u75c5\u7efc\u5408\u5f81( CRES )\u5206\u7ea7(\u95e8\u8bca\u7ba1\u7406\uff0c\u8003\u8651\u5305\u62ec\u62a4\u7406\u4eba\u5458)\uff1b<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">(10)\t\u53ca\u65f6\u89e3\u51b3\u7236\u6bcd\u548c\/\u6216\u7167\u987e\u8005\u7684\u62c5\u5fe7\uff0c\u56e0\u4e3aCRS\u7684\u65e9\u671f\u75c7\u72b6\u6216\u4f53\u5f81\u53ef\u80fd\u5f88\u5fae\u5999\uff0c\u6700\u4e86\u89e3\u5b69\u5b50\u7684\u4eba\u4f1a\u6700\u6e05\u695a\uff1b<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">(11) \u5efa\u8bae\u5728CAR-T\u7ec6\u80de\u6ce8\u5165\u540e\u7684\u524d\u4e24\u5468\u5185\uff0c\u5982\u679c\u60a3\u8005\u53d1\u751f\u4ee5\u4e0b4\u79cd\u75c7\u72b6\u6216\u8005\u4f53\u5f81\uff0c\u5e94\u8be5\u88ab\u6000\u7591\u662f\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81CRS\uff1a\u53d1\u70e7\u22658\u00b0C\uff1b\u4f4e\u8840\u538b\uff08\u5bf9\u4e8e1-10\u5c81\u60a3\u8005\uff0c\u6536\u7f29\u538b\uff1c\uff0870+\uff082*\u5e74\u9f84\uff09mmHg\uff09\uff1b\u5bf9\u4e8e10\u5c81\u4ee5\u4e0a\u513f\u7ae5\u60a3\u8005\uff0c\u6536\u7f29\u538b\u4f4e\u4e8e90 mmHg\uff09\uff1b\u57fa\u7ebf\u6539\u53d8\u548c\/\u6216\u964d\u4f4e\u6162\u6027\u6297\u9ad8\u8840\u538b\u836f\u7269\u7684\u8981\u6c42\uff1b\u52a8\u8109\u6c27\u9971\u548c\u5ea6\u5c0f\u4e8e90%\uff1b\u6216\u8005\u53c2\u7167\u901a\u7528\u4e0d\u826f\u4e8b\u4ef6\u672f\u8bed\u6807\u51c6\u7cfb\u7edf\uff08CTCAE 5.0\u7248\u672c\uff09\u6240\u660e\u786e\u7684\u5668\u5b98\u6bd2\u6027\u8bc1\u636e\uff1b<\/p>\n<p>(12) \u5efa\u8bae\u9ad8\u5ea6\u8b66\u60d5\u7aa6\u6027\u5fc3\u52a8\u8fc7\u901f\uff08sinus tachycardia\uff09\uff0c\u8fd9\u662fCRS\u7684\u4e00\u4e2a\u65e9\u671f\u5f81\u5146\uff1b<\/p>\n<p>(13) \u5efa\u8bae\u5e94\u7528\u5c0f\u513f\u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81\u4f5c\u4e3aCRS\u7f3a\u6c27\u5206\u7ea7\u6807\u51c6\uff1b<\/p>\n<p>(14)\t\u5efa\u8bae\u513f\u7ae5\u6025\u6027\u80be\u635f\u4f24\u53ef\u4ee5\u4f9d\u636eCTCAE\u5206\u7ea7\uff1b<\/p>\n<p>(15)\t\u5efa\u8bae\u513f\u7ae5\u60a3\u8005Tocilizumab\u7528\u91cf\uff1a\u4f53\u91cd\uff1c30kg\uff0c\u836f\u91cf\u4e3a12mg\/kg\uff1b\u4f53\u91cd\u226530 kg\uff0c\u836f\u91cf\u4e3a8 mg\/kg\uff1b<\/p>\n<p>(16)\tCAR-T\u76f8\u5173\u7684\u566c\u8840\u7ec6\u80de\u6027\u7f51\u72b6\u7ec6\u80de\u589e\u751f\u75c7\uff08HLH\uff09\u4ee5\u53ca\u5de8\u566c\u7ec6\u80de\u6d3b\u5316\u7efc\u5408\u5f81\uff08MAS\uff09\u5df2\u88ab\u8bc1\u5b9e\u53ef\u4ee5\u901a\u8fc7\u6297IL-6\u6cbb\u7597\u3001\u76ae\u8d28\u7c7b\u56fa\u9187\u89e3\u51b3\uff1b<\/p>\n<p>(17)\t\u5efa\u8bae\u4f7f\u7528Cornell Assessment\uff08CAPD\uff09\u7b5b\u67e5\u60a3\u8005\u7684\u795e\u5fd7\u4e0d\u6e05\uff08\u6216\u8005CARTOX-10\u5206\u7ea7\u7cfb\u7edf\u68c0\u67e512\u5c81\u4ee5\u4e0a\u5df2\u6709\u8db3\u591f\u8ba4\u77e5\u80fd\u529b\u7684\u60a3\u8005\uff09\uff0c\u68c0\u67e5\u9891\u7387\u4e3a\u6bcf24\u5c0f\u65f6\u81f3\u5c11\u8fdb\u884c\u4e24\u6b21\uff1b<\/p>\n<p>(18)\t\u5efa\u8bae\u4e0e\u91cd\u75c7\u76d1\u62a4\u5ba4\u8fdb\u884c\u524d\u77bb\u6027\u7684\u5408\u4f5c\uff0c\u4ee5\u4fbf\u51c6\u786e\u5730\u5c06\u7ec6\u80de\u6cbb\u7597\u53d8\u91cf\u5f55\u5165CIBMTR\u767b\u8bb0\u5904\uff0c\u540c\u65f6\u5c06\u91cd\u75c7\u76d1\u62a4\u53d8\u91cf\u5f55\u5165\u76f8\u5e94\u7684\u6ce8\u518c\u4e2d\u5fc3\uff1b<\/p>\n<p>(19)\t\u5f3a\u70c8\u652f\u6301\u8003\u8651\u513f\u79d1\u60a3\u8005\u7684\u8d28\u91cf\u8c03\u6574\u5bff\u547d\u5e74\uff08QALYs\uff09\uff0c\u52aa\u529b\u964d\u4f4e\u62a4\u7406\u6210\u672c\uff1b<\/p>\n<p>(20)\t\u5efa\u8baeCAR-T\u7597\u6cd5\u4f9d\u636e\u7ec6\u80de\u6cbb\u7597\u8ba4\u8bc1\u57fa\u91d1\u4f1a\uff08FACT\uff09\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u8ba4\u8bc1\uff0c\u4f5c\u4e3a\u786e\u4fdd\u9075\u5b88\u8d28\u91cf\u6807\u51c6\u7684\u81ea\u613f\u624b\u6bb5\u3002<\/p>\n<p style=\"text-align: justify;\">\u533b\u5b66\u535a\u58ebElizabeth Shpall\u8bf4:\u201cCARTOX\u8d1f\u8d23\u76d1\u7763\u5bf9MD Anderson CAR-T\u7ec6\u80de\u7597\u6cd5\u60a3\u8005\u7684\u62a4\u7406\uff0c\u662f\u9996\u4e2a\u83b7\u5f97\u7ec6\u80de\u7597\u6cd5\u8ba4\u8bc1\u57fa\u91d1\u4f1a\uff08Foundation for the Accreditation of Cellular Therapy \uff0cFACT\uff09\u8ba4\u8bc1\u7684\u72ec\u7acb\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u7597\u6cd5\u9879\u76ee\u3002\u8be5\u9879\u76ee\u4e3a20\u591a\u9879\u4e3b\u52a8\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u7814\u7a76\u65b9\u6848\u548cMD Anderson\u4e2d\u5fc3\u4e24\u9879\u8ba4\u53ef\u7684\u62a4\u7406\u6cbb\u7597\u6807\u51c6\u63d0\u4f9b\u76d1\u7763\uff0c\u65e0\u7591\uff0c\u8fd9\u4e9b\u65b0\u6307\u5357\u5c06\u6210\u4e3aCAR-T\u7ec6\u80de\u60a3\u8005\u62a4\u7406\u7684\u91cd\u8981\u65b0\u6a21\u5f0f\u3002\u201d<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: right;\"><strong>\u8d23\u7f16\uff1a\u6d6e\u82cf<\/strong><\/p>\n<section  class=\"\" style=\"white-space: normal;max-width: 100%;color: rgb(51, 51, 51);\">\n<section  style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  class=\"\" style=\"max-width: 100%;line-height: 28.4444px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section  style=\"margin: 1em auto;max-width: 100%;border-width: 0px;border-style: none;border-color: initial;text-align: center;width: 941px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span class=\"\"  style=\"max-width: 100%;width: 941px;border-bottom: 1px solid rgb(172, 29, 16);border-top-color: rgb(172, 29, 16);border-right-color: rgb(172, 29, 16);border-left-color: rgb(172, 29, 16);display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/p>\n<section class=\"\" style=\"margin-bottom: -3px;padding-top: 5px;padding-right: 10px;padding-left: 10px;max-width: 100%;display: inline-block;min-height: 32px;border-bottom: 5px solid rgb(172, 29, 16);font-size: 20px;color: rgb(121, 121, 121);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-top: 5px;margin-bottom: 5px;max-width: 100%;min-height: 1em;line-height: 1.6em;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">End<\/p>\n<\/section>\n<p><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"\" style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u53c2\u8003\u8d44\u6599\uff1a1\uff09Acute lymphoblastic leukemia: Comprehensive pediatric CAR-T guidelines developed<\/span><\/p>\n<p class=\"\" style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\">2\uff09Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br  \/><\/p>\n<section  class=\"\" style=\"font-size: 16px;white-space: normal;max-width: 100%;box-sizing: border-box;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);line-height: 25.6px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-width: 0px;border-style: none;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"padding: 2px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: dotted;border-color: rgb(218, 98, 71);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin: 5px auto;max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;width: 50px;float: left;border-top: 2px solid rgb(172, 29, 16);border-right-color: rgb(172, 29, 16);border-bottom-color: rgb(172, 29, 16);border-left: 2px solid rgb(172, 29, 16);color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;display: inline-block;color: rgb(172, 29, 16);clear: both;border-color: rgb(172, 29, 16);word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<section class=\"\"  style=\"margin: -0.8em 0.3em;padding: 0.8em;max-width: 100%;box-sizing: border-box;color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;overflow-wrap: break-word;color: rgb(51, 51, 51);font-size: 1em;line-height: 1.75em;word-break: break-all;box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"max-width: 100%;color: rgb(0, 0, 0);line-height: 22.4px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u672c\u6587\u7cfb\u751f\u7269\u63a2\u7d22\u539f\u521b\uff0c\u6b22\u8fce\u4e2a\u4eba\u8f6c\u53d1\u5206\u4eab\u3002\u5176\u4ed6\u4efb\u4f55\u5a92\u4f53\u3001\u7f51\u7ad9\u5982\u9700\u8f6c\u8f7d\uff0c\u987b\u5728\u6b63\u6587\u524d\u6ce8\u660e\u6765\u6e90\u751f\u7269\u63a2\u7d22\u3002<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;width: 50px;float: right;border-bottom: 2px solid rgb(172, 29, 16);border-top-color: rgb(172, 29, 16);border-right: 2px solid rgb(172, 29, 16);border-left-color: rgb(172, 29, 16);color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"\" style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress1-1533788124.png\" alt=\"Nature\u5b50\u520a\u9881\u5e03CAR-T\u7597\u6cd5\u6307\u5357\uff01\u5173\u8054\u513f\u7ae5\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\" title=\"Nature\u5b50\u520a\u9881\u5e03CAR-T\u7597\u6cd5\u6307\u5357\uff01\u5173\u8054\u513f\u7ae5\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\"><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u751f\u7269\u63a2\u7d22                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u751f\u7269\u63a2\u7d22 \u7f16\u8005\u6309 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