{"id":31338,"date":"2018-08-08T01:00:00","date_gmt":"2018-08-09T04:15:32","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e6%96%b0%e5%8f%91%e7%8e%b0%ef%bc%81%e5%a4%a7%e8%84%91%e7%bb%86%e8%83%9e%e7%9a%84ph%e5%a4%b1%e8%a1%a1%e5%8f%af%e8%83%bd%e5%af%bc%e8%87%b4%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%87\/"},"modified":"2018-08-09T12:15:34","modified_gmt":"2018-08-09T04:15:34","slug":"%e6%96%b0%e5%8f%91%e7%8e%b0%ef%bc%81%e5%a4%a7%e8%84%91%e7%bb%86%e8%83%9e%e7%9a%84ph%e5%a4%b1%e8%a1%a1%e5%8f%af%e8%83%bd%e5%af%bc%e8%87%b4%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e7%97%87","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/31338\/","title":{"rendered":"\u65b0\u53d1\u73b0\uff01\u5927\u8111\u7ec6\u80de\u7684pH\u5931\u8861\u53ef\u80fd\u5bfc\u81f4\u963f\u5c14\u8328\u6d77\u9ed8\u75c7"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  class=\"\" style=\"font-size: 16px;white-space: normal;max-width: 100%;text-align: justify;background-color: rgb(255, 255, 255);letter-spacing: 0.476px;color: rgb(62, 62, 62);font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"padding: 0.8em;max-width: 100%;border-width: 1px 0.4em;border-style: solid;border-color: rgb(172, 29, 16);border-radius: 0.3em;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u6ca1\u6709\u6cbb\u6108\u7684\u65b9\u6cd5\uff0c\u4e5f\u6ca1\u6709\u9884\u9632\u6216\u9006\u8f6c\u5176\u75c7\u72b6\u7684\u836f\u7269\u3002\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66\u7684\u533b\u5b66\u79d1\u5b66\u5bb6\u5728\u5b9e\u9a8c\u5ba4\u57f9\u80b2\u7684\u5c0f\u9f20\u8111\u7ec6\u80de\u4e2d\u53d1\u73b0\u4e86\u65b0\u7684\u8bc1\u636e\uff0c\u5728\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u6838\u5185\u4f53\u7684pH\u5931\u8861\u53ef\u80fd\u662f\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u7684\u6839\u6e90\u3002\u4ed6\u4eec\u4f7f\u7528\u7ec4\u86cb\u767d\u8131\u4e59\u9170\u9176\uff08HDAC\uff09\u6291\u5236\u5242\u7684\u836f\u7269\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u57fa\u56e0\u53d8\u4f53\u7684pH-\u5931\u8861\u5c0f\u9f20\u7ec6\u80de\uff0c\u6210\u529f\u5730\u9006\u8f6c\u4e86pH\u503c\u95ee\u9898\uff0c\u63d0\u9ad8\u4e86\u6e05\u9664\u6dc0\u7c89\u6837\u86cb\u767d\u7684\u80fd\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><img class=\"\"     style=\"border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533788133.jpeg\" alt=\"\u65b0\u53d1\u73b0\uff01\u5927\u8111\u7ec6\u80de\u7684pH\u5931\u8861\u53ef\u80fd\u5bfc\u81f4\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\" title=\"\u65b0\u53d1\u73b0\uff01\u5927\u8111\u7ec6\u80de\u7684pH\u5931\u8861\u53ef\u80fd\u5bfc\u81f4\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\"><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"color: rgb(136, 136, 136);font-size: 14px;\">Illustration of how pH imbalance inside endosomes may contribute to Alzheimer&#8217;s disease.Credit: Hari Prasad<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\">\u8fd9\u9879\u65b0\u7814\u7a76\u53d1\u8868\u57286\u670826\u65e5\u7684\u300aPNAS\u300b\u4e0a\uff0c\u9898\u76ee\u4e3a\u201cAmyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH\u201d\u3002<\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\">\n<p style=\"line-height: 1.75em;text-align: center;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\">\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u5728\u795e\u7ecf\u5143\u4e4b\u95f4\u6e05\u9664\u6dc0\u7c89\u6837\u03b2\u86cb\u767d\uff0c\u4f46\u5982\u679c\u6e05\u9664\u8fc7\u7a0b\u51fa\u9519\uff0c\u6dc0\u7c89\u6837\u86cb\u767d\u5806\u79ef\u5728\u795e\u7ecf\u5143\u5468\u56f4\uff0c\u5bfc\u81f4\u5f62\u6210\u5178\u578b\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u6591\u5757\u548c\u795e\u7ecf\u7ec6\u80de\u9000\u5316\uff0c\u8fd9\u662f\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u8bb0\u5fc6\u7834\u574f\u7684\u6807\u5fd7\u3002<br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: 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justify;\">Prasad\u548cRao\u8fd8\u53d1\u73b0\u4e00\u79cd\u53eb\u505aLRP1\u7684\u86cb\u767d\u8d28\uff0c\u5b83\u5728\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u5916\u63d0\u53d6\u6dc0\u7c89\u6837\u86cb\u767d\uff0c\u5e76\u5c06\u5176\u8f93\u9001\u5230\u6838\u5185\u4f53\uff0c\u5728\u5b9e\u9a8c\u5ba4\u57f9\u517b\u7684\u5c0f\u9f20\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u4e2d\uff0c\u6709\u4e00\u534a\u662f\u7531\u4e00\u79cd\u53eb\u505aAPOE4\u7684\u4eba\u7c7b\u57fa\u56e0\u53d8\u5f02\u800c\u6210\u7684\uff0c\u901a\u5e38\u4e0e\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u6709\u5173\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\">\u4e3a\u4e86\u5bfb\u627e\u6062\u590dNHE6\u529f\u80fd\u7684\u65b9\u6cd5\uff0cPrasad\u68c0\u7d22\u4e86\u9175\u6bcd\u7814\u7a76\u7684\u6570\u636e\u5e93\uff0c\u53d1\u73b0HDAC\u6291\u5236\u5242\u80fd\u589e\u52a0\u9175\u6bcd\u4e2dNHE6\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u8fd9\u79cd\u57fa\u56e0\u5728\u4e0d\u540c\u7269\u79cd\u4e2d\u975e\u5e38\u76f8\u4f3c\uff0c\u5305\u62ec\u82cd\u8747\u3001\u8001\u9f20\u548c\u4eba\u7c7b\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: justify;\">Prasad\u548cRao\u5728\u7528APOE4\u57fa\u56e0\u53d8\u5f02\u7684\u5c0f\u9f20\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u57f9\u517b\u6db2\u4e2d\u6d4b\u8bd5\u4e86\u4e5d\u79cdHDAC\u6291\u5236\u5242\u3002\u5e7f\u8c31HDAC\u6291\u5236\u5242\u5c06NHE6\u8868\u8fbe\u589e\u52a0\u5230\u4e0e\u6ca1\u6709\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u57fa\u56e0\u53d8\u5f02\u5c0f\u9f20\u7684\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u76f8\u5173\u7684\u6c34\u5e73\u3002\u4ed6\u4eec\u8fd8\u53d1\u73b0\uff0cHDAC\u6291\u5236\u5242\u7ea0\u6b63\u4e86\u5185\u4f53\u4e2d\u7684pH\u503c\u5931\u8861\uff0c\u5e76\u5c06LRP1\u6062\u590d\u5230\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u8868\u9762\uff0c\u4ece\u800c\u6709\u6548\u5730\u6e05\u9664\u4e86\u6dc0\u7c89\u6837\u86cb\u767d\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: right;\"><strong>\u8d23\u7f16\uff1a\u98ce\u94c3<\/strong><\/p>\n<section  class=\"\" style=\"white-space: normal;max-width: 100%;color: rgb(51, 51, 51);\">\n<section  style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  class=\"\" style=\"max-width: 100%;line-height: 28.4444px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section  style=\"margin: 1em auto;max-width: 100%;border-width: 0px;border-style: none;border-color: initial;text-align: center;width: 941px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span class=\"\"  style=\"max-width: 100%;width: 941px;border-bottom: 1px solid rgb(172, 29, 16);border-top-color: rgb(172, 29, 16);border-right-color: rgb(172, 29, 16);border-left-color: rgb(172, 29, 16);display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/p>\n<section class=\"\" style=\"margin-bottom: -3px;padding-top: 5px;padding-right: 10px;padding-left: 10px;max-width: 100%;display: inline-block;min-height: 32px;border-bottom: 5px solid rgb(172, 29, 16);font-size: 20px;color: rgb(121, 121, 121);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-top: 5px;margin-bottom: 5px;max-width: 100%;min-height: 1em;line-height: 1.6em;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">End<\/p>\n<\/section>\n<p><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"\" style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u53c2\u8003\u8d44\u6599\uff1a1\uff09pH imbalance in brain cells may contribute to Alzheimer&#8217;s disease<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br  \/><\/p>\n<section  class=\"\" style=\"font-size: 16px;white-space: normal;max-width: 100%;box-sizing: border-box;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);line-height: 25.6px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-width: 0px;border-style: none;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"padding: 2px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: dotted;border-color: rgb(218, 98, 71);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin: 5px auto;max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;width: 50px;float: left;border-top: 2px solid rgb(172, 29, 16);border-right-color: rgb(172, 29, 16);border-bottom-color: rgb(172, 29, 16);border-left: 2px solid rgb(172, 29, 16);color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;display: inline-block;color: rgb(172, 29, 16);clear: both;border-color: rgb(172, 29, 16);word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<section class=\"\"  style=\"margin: -0.8em 0.3em;padding: 0.8em;max-width: 100%;box-sizing: border-box;color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;overflow-wrap: break-word;color: rgb(51, 51, 51);font-size: 1em;line-height: 1.75em;word-break: break-all;box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"max-width: 100%;color: rgb(0, 0, 0);line-height: 22.4px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u672c\u6587\u7cfb\u751f\u7269\u63a2\u7d22\u539f\u521b\uff0c\u6b22\u8fce\u4e2a\u4eba\u8f6c\u53d1\u5206\u4eab\u3002\u5176\u4ed6\u4efb\u4f55\u5a92\u4f53\u3001\u7f51\u7ad9\u5982\u9700\u8f6c\u8f7d\uff0c\u987b\u5728\u6b63\u6587\u524d\u6ce8\u660e\u6765\u6e90\u751f\u7269\u63a2\u7d22\u3002<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;width: 50px;float: right;border-bottom: 2px solid rgb(172, 29, 16);border-top-color: rgb(172, 29, 16);border-right: 2px solid rgb(172, 29, 16);border-left-color: rgb(172, 29, 16);color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"\" style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533788133.png\" alt=\"\u65b0\u53d1\u73b0\uff01\u5927\u8111\u7ec6\u80de\u7684pH\u5931\u8861\u53ef\u80fd\u5bfc\u81f4\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\" title=\"\u65b0\u53d1\u73b0\uff01\u5927\u8111\u7ec6\u80de\u7684pH\u5931\u8861\u53ef\u80fd\u5bfc\u81f4\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\"><\/p>\n<p><br  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u751f\u7269\u63a2\u7d22                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u6ca1\u6709\u6cbb\u6108\u7684\u65b9\u6cd5\uff0c\u4e5f\u6ca1\u6709\u9884\u9632\u6216\u9006\u8f6c\u5176\u75c7\u72b6\u7684\u836f\u7269\u3002\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66\u7684\u533b\u5b66\u79d1\u5b66\u5bb6\u5728\u5b9e\u9a8c\u5ba4\u57f9\u80b2 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":31339,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/31338"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=31338"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/31338\/revisions"}],"predecessor-version":[{"id":31347,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/31338\/revisions\/31347"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/31339"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=31338"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=31338"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=31338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}