{"id":31356,"date":"2018-08-07T01:00:00","date_gmt":"2018-08-09T04:15:40","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e9%87%8d%e7%a3%85%ef%bc%81%e4%b8%a4%e7%af%87nature%e5%85%b1%e5%90%8c%e6%8f%ad%e7%a4%ba%ef%bc%9a%e6%96%b0%e5%9e%8b%e8%82%ba%e7%bb%86%e8%83%9e\/"},"modified":"2018-08-09T12:15:42","modified_gmt":"2018-08-09T04:15:42","slug":"%e9%87%8d%e7%a3%85%ef%bc%81%e4%b8%a4%e7%af%87nature%e5%85%b1%e5%90%8c%e6%8f%ad%e7%a4%ba%ef%bc%9a%e6%96%b0%e5%9e%8b%e8%82%ba%e7%bb%86%e8%83%9e","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/31356\/","title":{"rendered":"\u91cd\u78c5\uff01\u4e24\u7bc7Nature\u5171\u540c\u63ed\u793a\uff1a\u65b0\u578b\u80ba\u7ec6\u80de"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"\" label=\"Copyright \u00a9 2015 Yead All Rights Reserved.\" style=\"max-width: 100%;color: rgb(51, 51, 51);\">\n<fieldset style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: 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inline-block;border-radius: 0px 0.5em 0.5em 0px;font-size: 1em;font-family: inherit;background-color: rgb(197, 63, 70);word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u751f\u7269\u63a2\u7d22<\/section>\n<p><\/span><\/p>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;width: 0px;border-right: 4px solid rgb(197, 63, 70);border-top: 4px solid rgb(197, 63, 70);word-wrap: break-word !important;overflow-wrap: break-word !important;border-left: 4px solid transparent !important;border-bottom: 4px solid transparent !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: 27.2656px;padding-right: 8px;padding-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 1.5em;font-family: inherit;text-align: inherit;text-decoration: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u7f16\u8005\u6309<\/strong><\/span><\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;clear: both;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<section style=\"padding: 8px;max-width: 100%;box-sizing: border-box;line-height: 30px;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">8\u67081\u65e5\uff0c\u300aNature\u300b\u8fde\u53d1\u4e24\u7bc7\u6587\u7ae0\uff0c\u540c\u65f6\u63ed\u793a\u4e86\u4e00\u79cd\u65b0\u578b\u80ba\u7ec6\u80de\u2014\u2014\u201c\u80ba\u90e8\u79bb\u5b50\u7ec6\u80de\u201d\uff08pulmonary ionocyte\uff09\u3002\u4e24\u4e2a\u4e0d\u540c\u7684\u7814\u7a76\u56e2\u961f\u5229\u7528\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u6280\u672f\u5bf9\u4eba\u7c7b\u4ee5\u53ca\u5c0f\u9f20\u7684\u547c\u5438\u9053\u7ec6\u80de\u7ed8\u5236\u4e86\u8be6\u7ec6\u7684\u5206\u5b50\u56fe\u8c31\uff0c\u4ece\u4e2d\u53d1\u73b0\u4e86\u65b0\u7684\u77e5\u8bc6\u70b9\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/fieldset>\n<\/section>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"     style=\"margin-top: 6px;margin-bottom: 6px;border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress0-1533788141.jpeg\" alt=\"\u91cd\u78c5\uff01\u4e24\u7bc7Nature\u5171\u540c\u63ed\u793a\uff1a\u65b0\u578b\u80ba\u7ec6\u80de\" title=\"\u91cd\u78c5\uff01\u4e24\u7bc7Nature\u5171\u540c\u63ed\u793a\uff1a\u65b0\u578b\u80ba\u7ec6\u80de\"  \/><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><span style=\"color: rgb(136, 136, 136);\">\u80ba\u90e8\u79bb\u5b50\u7ec6\u80de\uff08\u6a59\u8272\uff09\u901a\u8fc7\u90bb\u8fd1\u7684\u4e0a\u76ae\u7ec6\u80de\uff08\u7ec6\u80de\u6838\uff0c\u9752\u8272\uff09\u5ef6\u4f38\u81f3\u547c\u5438\u4e0a\u76ae\u5c42\u3002\u8fd9\u4e00\u65b0\u53d1\u73b0\u7684\u7ec6\u80de\u7c7b\u578b\u4f1a\u9ad8\u5ea6\u8868\u8fbeCFTR\uff0c\u4e00\u79cd\u7a81\u53d8\u65f6\u4e0e\u56ca\u6027\u7ea4\u7ef4\u5316\u6709\u5173\u7684\u57fa\u56e0\u3002\uff08\u56fe\u7247\u6765\u6e90\uff1aANNA HUPALOWSKA, DANIEL MONTORO\uff09<\/span><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\">\u8fd9\u4e24\u4efd\u56f4\u7ed5\u201c\u547c\u5438\u4e0a\u76ae\u7ec6\u80de\u201d\u7684\u6700\u65b0\u7814\u7a76\u63ed\u793a\u4e86\u6570\u5343\u4e2a\u80ba\u7ec6\u80de\u7684\u57fa\u56e0\u8868\u8fbe\u6a21\u5f0f\uff0c\u4ece\u4e2d\u6316\u6398\u51fa\u4e00\u79cd\u524d\u6240\u672a\u77e5\u7684\u65b0\u578b\u80ba\u7ec6\u80de\uff0c\u5373<strong>\u80ba\u90e8\u79bb\u5b50\u7ec6\u80de\u3002<\/strong>\u66f4\u91cd\u8981\u7684\u662f\uff0c<strong>\u8fd9\u4e00\u65b0\u7ec6\u80de\u4f1a\u9ad8\u5ea6\u8868\u8fbe\u4e00\u79cd\u4e0e\u56ca\u6027\u7ea4\u7ef4\u5316\u6709\u5173\u7684\u7a81\u53d8\u57fa\u56e0\u2014\u2014\u56ca\u6027\u7ea4\u7ef4\u8de8\u819c\u8f6c\u5bfc\u8c03\u63a7\u56e0\u5b50CFTR\uff08cystic fibrosis transmembrane conductance regulator\uff09<\/strong>\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\">\u56ca\u6027\u7ea4\u7ef4\u5316\u662f\u4e00\u79cd\u9057\u4f20\u6027\u5916\u5206\u6ccc\u817a\u75be\u75c5\uff0c\u4e3b\u8981\u5f71\u54cd\u80c3\u80a0\u9053\u548c\u547c\u5438\u7cfb\u7edf\u3002CFTR\u7f3a\u4e4f\u548c\u7f3a\u9677\u5bb9\u6613\u5bfc\u81f4\u7c98\u6db2\u589e\u539a\u3001\u6c14\u9053\u5835\u585e\u548c\u53cd\u590d\u611f\u67d3\u3002<\/p>\n<p style=\"white-space: normal;text-align: justify;\"><br  \/><\/p>\n<section class=\"\"  style=\"white-space: normal;max-width: 100%;color: rgb(51, 51, 51);\">\n<section style=\"margin: 10px auto;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 3px;margin-left: 33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"margin-bottom: 10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span>&nbsp;&nbsp;&nbsp;<\/span><\/section>\n<section style=\"margin-top: -2px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: bottom;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<section style=\"max-width: 100%;display: inline-block;border-width: 1px;border-style: solid;border-color: rgb(255, 255, 255);width: 30px;height: 30px;line-height: 30px;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-right: auto;margin-left: auto;max-width: 100%;min-height: 1em;white-space: pre-wrap;min-width: 1px;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">01<\/p>\n<\/section>\n<section style=\"max-width: 100%;display: inline-block;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: 3px;margin-left: -33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span><span style=\"margin-bottom: -10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span>&nbsp; &nbsp;<\/span><\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(123, 12, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"text-align: justify;\">\u8bba\u6587\u4e00<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(123, 12, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\">A revised airway epithelial hierarchy includes CFTR-expressing ionocytes<\/span><\/strong><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\"><img class=\"\"     style=\"margin-top: 6px;margin-bottom: 6px;border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress5-1533788141.jpeg\" alt=\"\u91cd\u78c5\uff01\u4e24\u7bc7Nature\u5171\u540c\u63ed\u793a\uff1a\u65b0\u578b\u80ba\u7ec6\u80de\" title=\"\u91cd\u78c5\uff01\u4e24\u7bc7Nature\u5171\u540c\u63ed\u793a\uff1a\u65b0\u578b\u80ba\u7ec6\u80de\"  \/><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\">\u54c8\u4f5b\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u9ebb\u7701\u603b\u533b\u9662\uff08MGH\uff09\u7684\u80ba\u5185\u79d1\u533b\u751fJayaraj Rajagopal\u4e00\u76f4\u5728\u7814\u7a76\u80ba\u518d\u751f\uff0c\u5e76\u5e0c\u671b\u901a\u8fc7\u5355\u7ec6\u80de\u6d4b\u5e8f\u5206\u6790\u80ba\u5e72\u7ec6\u80de\u7fa4\u7684\u5dee\u5f02\u3002\u4ed6\u548cBroad\u7814\u7a76\u6240\u7684\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6Aviv Regev\u56e2\u961f\u5408\u4f5c\uff0c\u5171\u540c\u9274\u5b9a\u4e86\u6210\u5e74\u5c0f\u9f20\u5668\u5b98\u4e2d\u6570\u5343\u4e2a\u4e0a\u76ae\u7ec6\u80de\u7684\u8f6c\u5f55\u56fe\u8c31\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\">\u7814\u7a76\u56e2\u961f\u5206\u6790\u4e86\u4e24\u79cd\u6700\u5e38\u89c1\u7684\u7ec6\u80de\u7c7b\u578b\uff1a\u5206\u6ccc\u7ec6\u80de\uff08club cells\uff09\uff0c\u5206\u6ccc\u547c\u5438\u9053\u7c98\u6db2\u6210\u5206\uff0c\u5305\u62ec\u6297\u83cc\u5206\u5b50\u4ee5\u53ca\u514d\u75ab\u8c03\u63a7\u86cb\u767d\uff1b\u7ea4\u6bdb\u7ec6\u80de\uff08ciliated cells\uff09\uff0c\u643a\u5e26\u4e00\u79cd\u53eb\u505a\u7ea4\u6bdb\u7684\u7a81\u51fa\u7ed3\u6784\uff0c\u8d1f\u8d23\u6e05\u9664\u7c98\u6db2\u548c\u788e\u7247\u5783\u573e\u3002\u6b64\u5916\uff0c\u4ed6\u4eec\u8fd8\u5206\u6790\u4e86\u4e00\u4e9b\u7f55\u89c1\u3001\u4e0d\u5e38\u89c1\u7684\u7ec6\u80de\u7c7b\u578b\uff0c\u5305\u62ec\u4ea7\u751f\u7c98\u6db2\u86cb\u767d\u7684\u676f\u72b6\u7ec6\u80de\uff08goblet cells\uff09\u3001\u626e\u6f14\u514d\u75ab\u4f20\u611f\u5668\u7684\u7c07\u72b6\u7ec6\u80de\uff08tuft cells\uff09\u3001\u611f\u77e5\u6c27\u6c14\u6c34\u5e73\u548c\u4f20\u9012\u4fe1\u53f7\u7684\u795e\u7ecf\u5185\u5206\u6ccc\u7ec6\u80de\uff08neuroendocrine cells\uff09\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\">\u7ed3\u679c\u663e\u793a\uff0c\u4e0a\u76ae\u7ec6\u80de\u4e0b\u5c42\u7684\u57fa\u5e95\u7ec6\u80de\uff08basal cells\uff09\u4e0d\u4ec5\u4ec5\u76f4\u63a5\u751f\u6210\u5206\u6ccc\u7ec6\u80de\uff0c\u8fd8\u4f1a\u751f\u6210\u9664\u4e86\u676f\u72b6\u7ec6\u80de\u4ee5\u5916\u7684\u6240\u6709\u7f55\u89c1\u7ec6\u80de\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u6709\u51e0\u7ec4\u547c\u5438\u9053\u7ec6\u80de\u57fa\u56e0\u8868\u8fbe\u6a21\u5f0f\u5b58\u5728\u524d\u6240\u672a\u77e5\u7684\u57fa\u56e0\u8868\u8fbe\u5dee\u5f02\uff0c\u4ee5\u53ca\u53d1\u73b0\u80ba\u90e8\u65b0\u7684\u7ed3\u6784\u548c\u7ec6\u80de\u5206\u5316\u7684\u65b0\u9014\u5f84\u3002\u4ed6\u4eec\u8fd8\u63ed\u793a\u4e86\u51e0\u79cd\u65b0\u7684\u7ec6\u80de\u7c7b\u578b\uff0c\u5e76\u5c06\u5176\u4e2d\u4e00\u79cd\u547d\u540d\u4e3a<strong>\u201c\u80ba\u90e8\u79bb\u5b50\u7ec6\u80de\u201d\uff08pulmonary ionocyte\uff09\u3002<\/strong><\/p>\n<p style=\"white-space: normal;text-align: justify;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\"><img class=\"\"     style=\"margin-top: 6px;margin-bottom: 6px;border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress2-1533788141-1.jpeg\" alt=\"\u91cd\u78c5\uff01\u4e24\u7bc7Nature\u5171\u540c\u63ed\u793a\uff1a\u65b0\u578b\u80ba\u7ec6\u80de\" title=\"\u91cd\u78c5\uff01\u4e24\u7bc7Nature\u5171\u540c\u63ed\u793a\uff1a\u65b0\u578b\u80ba\u7ec6\u80de\"  \/><br  \/><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\">\u4ed6\u4eec\u53d1\u73b0\uff0c<strong>\u8fd9\u4e9b\u80ba\u90e8\u65b0\u7ec6\u80de\u7684\u57fa\u56e0\u8868\u8fbe\u6a21\u5f0f\u7c7b\u4f3c\u4e8e\u9c7c\u7c7b\u548c\u4e24\u6816\u7c7b\u7684\u79bb\u5b50\u7ec6\u80de<\/strong>\uff0c\u5305\u62ec\u8f6c\u5f55\u56e0\u5b50Foxi1\u7684\u7f16\u7801\u57fa\u56e0\u3002\u5728\u9c7c\u7c7b\u4e2d\uff0c\u79bb\u5b50\u7ec6\u80de\u901a\u5e38\u8d1f\u8d23\u8c03\u63a7\u52a8\u7269\u7ec4\u7ec7\u4e0e\u5468\u56f4\u6c34\u73af\u5883\u4e4b\u95f4\u7684\u94a0\u3001\u6c2f\u548c\u9499\u79bb\u5b50\u4ea4\u6362\uff0c\u4ece\u800c\u7ef4\u6301\u4f53\u6db2\u6eb6\u8d28\u6d53\u5ea6\u5e73\u8861\u3002\u76ee\u524d\u8fd8\u4e0d\u6e05\u695a\u5728\u54fa\u4e73\u52a8\u7269\u547c\u5438\u9053\u4e2d\uff0c\u80ba\u79bb\u5b50\u7ec6\u80de\u662f\u5426\u5177\u6709\u7c7b\u4f3c\u529f\u80fd\uff0c\u5373\u4fbf\u7ec6\u80de\u786e\u5b9e\u8868\u8fbe\u6709\u591a\u79cd\u79bb\u5b50\u8fd0\u8f93\u57fa\u56e0\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\">\u66f4\u91cd\u8981\u7684\u662f\uff0c\u7814\u7a76\u56e2\u961f\u53d1\u73b0\uff0c<strong>\u80ba\u90e8\u79bb\u5b50\u7ec6\u80de\u9ad8\u5ea6\u8868\u8fbeCFTR\uff0c\u800c\u4e14\u662fCFTR\u4e3b\u8981\u7684\u6765\u6e90<\/strong>\u3002CFTR\u662f\u4e00\u79cd\u6709\u52a9\u4e8e\u8c03\u63a7\u6db2\u4f53\u8fd0\u8f93\u548c\u7c98\u6db2\u6d53\u5ea6\u7684\u819c\u86cb\u767d\u3002\u5728\u5c0f\u9f20\u548c\u4eba\u7c7b\u80ba\u6a21\u578b\u4e2d\uff0c\u8fd9\u7c7b\u7ec6\u80de\u53ef\u80fd\u5728\u56ca\u6027\u7ea4\u7ef4\u5316\u4e2d\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\">\u201c\u6211\u4eec\u53d1\u73b0\u4e86\u5f88\u591a\u6539\u5199\u80ba\u90e8\u751f\u7269\u5b66\u7684\u65b0\u77e5\u8bc6\u70b9\u3002\u201d Rajagopal\u603b\u7ed3\u9053\u3002<\/p>\n<p style=\"white-space: normal;text-align: justify;\"><br  \/><\/p>\n<section class=\"\"  style=\"white-space: normal;max-width: 100%;color: rgb(51, 51, 51);\">\n<section style=\"margin: 10px auto;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 3px;margin-left: 33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"margin-bottom: 10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span>&nbsp;&nbsp;&nbsp;<\/span><\/section>\n<section style=\"margin-top: -2px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: bottom;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<section style=\"max-width: 100%;display: inline-block;border-width: 1px;border-style: solid;border-color: rgb(255, 255, 255);width: 30px;height: 30px;line-height: 30px;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-right: auto;margin-left: auto;max-width: 100%;min-height: 1em;white-space: pre-wrap;min-width: 1px;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">02<\/p>\n<\/section>\n<section style=\"max-width: 100%;display: inline-block;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: 3px;margin-left: -33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span><span style=\"margin-bottom: -10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span>&nbsp; &nbsp;<\/span><\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(123, 12, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8bba\u6587\u4e8c<\/span><\/strong><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(123, 12, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"font-size: 16px;color: rgb(123, 12, 0);max-width: 100%;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\">A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte<\/span><\/strong><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\">\u53e6\u4e00\u9879\u7814\u7a76\u7531\u8bfa\u534e\u516c\u53f8\u7684\u751f\u7269\u5b66\u5bb6Aron Jaffe\u548c\u54c8\u4f5b\u5927\u5b66\u7cfb\u7edf\u751f\u7269\u5b66\u5bb6Allon Klein\u5408\u4f5c\u5b8c\u6210\u3002Allon Klein\u4e4b\u524d\u5df2\u7ecf\u5f00\u53d1\u4e86\u4e00\u79cd\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u65b9\u6cd5\uff0cAron Jaffe\u5c06\u5176\u63cf\u8ff0\u4e3a<strong>\u201c\u4e00\u79cd\u5b8c\u7f8e\u7684\u6280\u672f\uff0c\u53ef\u4ee5\u5728\u547c\u5438\u9053\u4e0a\u5bf9\u5404\u79cd\u4e0a\u76ae\u7ec6\u80de\u8fdb\u884c\u5168\u9762\u7684\u89c2\u5bdf\u548c\u5206\u6790\u201d\u3002<\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\">\u4ed6\u4eec\u5bf9\u4eba\u7c7b\u652f\u6c14\u7ba1\u4e0a\u76ae\u7ec6\u80de\u548c\u5c0f\u9f20\u6c14\u7ba1\u4e0a\u76ae\u7ec6\u80de\u8fdb\u884cRNA\u6d4b\u5e8f\u3002\u540c\u6837\uff0c\u4ed6\u4eec\u4e5f\u53d1\u73b0\u4e86\u80ba\u90e8\u79bb\u5b50\u7ec6\u80de\uff0c\u4ee5\u53ca\u5728\u719f\u6089\u7684\u7ec6\u80de\u4e2d\u53d1\u73b0\u65b0\u7684\u57fa\u56e0\u8868\u8fbe\u6a21\u5f0f\u3002\u4e3a\u4e86\u66f4\u597d\u5730\u4e86\u89e3\u79bb\u5b50\u7ec6\u80de\u5728\u56ca\u6027\u7ea4\u7ef4\u5316\u4e2d\u53ef\u80fd\u7684\u4f5c\u7528\uff0c\u7814\u7a76\u56e2\u961f\u6bd4\u8f83\u4e86\u4eba\u7c7b\u548c\u5c0f\u9f20\u79bb\u5b50\u7ec6\u80de\u4e2dCFTR\u7684\u8868\u8fbe\u6a21\u5f0f\u3002\u4e0e\u5176\u4ed6\u7814\u7a76\u7ed3\u679c\u4e00\u81f4\u7684\u662f\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c<strong>\u80ba\u79bb\u5b50\u7ec6\u80de\u662f\u4eba\u7c7b\u548c\u5c0f\u9f20\u547c\u5438\u9053\u4e2dCFTR\u86cb\u767d\u7684\u4e3b\u8981\u6765\u6e90\u3002<\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\">\u201c\u53d1\u73b0\u8fd9\u4e00\u65b0\u578b\u7684\u7f55\u89c1\u7ec6\u80de\u7c7b\u578b\uff0c\u786e\u5b9e\u4ee4\u4eba\u60ca\u8bb6\u3002CFTR\u5df2\u7ecf\u88ab\u7814\u7a76\u4e86\u5f88\u957f\u4e00\u6bb5\u65f6\u95f4\uff0c\u88ab\u8ba4\u4e3a\u5728\u8bb8\u591a\u547c\u5438\u9053\u7ec6\u80de\u4e2d\u5e7f\u6cdb\u8868\u8fbe\u3002\u4f46\u662f\u73b0\u5728\u7684\u7ed3\u679c\u8868\u660e\uff0c\u4e0a\u76ae\u7ec6\u80de\u6bd4\u4e4b\u524d\u8ba4\u4e3a\u7684\u8981\u590d\u6742\u5f97\u591a\u3002\u201d Jaffe\u5f3a\u8c03\u9053\u3002<\/p>\n<p style=\"white-space: normal;text-align: justify;\"><br  \/><\/p>\n<section class=\"\"  style=\"white-space: normal;max-width: 100%;color: rgb(51, 51, 51);\">\n<section style=\"margin: 10px auto;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 3px;margin-left: 33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"margin-bottom: 10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span>&nbsp;&nbsp;&nbsp;<\/span><\/section>\n<section style=\"margin-top: -2px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: bottom;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<section style=\"max-width: 100%;display: inline-block;border-width: 1px;border-style: solid;border-color: rgb(255, 255, 255);width: 30px;height: 30px;line-height: 30px;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-right: auto;margin-left: auto;max-width: 100%;min-height: 1em;white-space: pre-wrap;min-width: 1px;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">03<\/p>\n<\/section>\n<section style=\"max-width: 100%;display: inline-block;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: 3px;margin-left: -33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span><span style=\"margin-bottom: -10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span>&nbsp; &nbsp;<\/span><\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(123, 12, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"text-align: justify;\">\u4e0b\u4e00\u6b65<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(123, 12, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"text-align: justify;\"><br  \/><\/span><\/span><\/strong><\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;\">\u73b0\u5728\uff0c\u7814\u7a76\u56e2\u961f\u5df2\u7ecf\u8868\u660e\u8f6c\u5f55\u56e0\u5b50Foxi1\u662f\u8fd9\u4e9b\u79bb\u5b50\u7ec6\u80de\u8f6c\u5f55\u7a0b\u5e8f\u7684\u6838\u5fc3\u3002\u4e0b\u4e00\u6b65\u95ee\u9898\u662f\uff1aFoxi1\u662f\u76f4\u63a5\u4e0eCFTR\u57fa\u56e0\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd8\u662f\u901a\u8fc7\u5176\u4ed6\u8f6c\u5f55\u56e0\u5b50\u6216\u5176\u4ed6\u86cb\u767d\u8c03\u63a7CFTR\u57fa\u56e0\u8868\u8fbe\uff1f<\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: justify;\">\u9664\u4e86\u7814\u7a76\u79bb\u5b50\u7ec6\u80de\u5728\u80ba\u529f\u80fd\u4e2d\u7684\u6f5c\u5728\u4f5c\u7528\u5916\uff0c\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\u8fd8\u53ef\u4ee5\u8fdb\u4e00\u6b65\u5206\u6790\u6700\u65b0\u6570\u636e\uff0c\u7279\u522b\u662f\u5173\u4e8e\u8f6c\u5f55\u56e0\u5b50\u548c\u7ec6\u80de\u8868\u9762\u6807\u8bb0\u7684\u7f16\u7801\u57fa\u56e0\u7684\u8868\u8fbe\u7ec6\u8282\u3002<\/p>\n<p style=\"white-space: normal;text-align: justify;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: right;\"><strong>\u8d23\u7f16\uff1a\u98ce\u94c3<\/strong><\/p>\n<section  class=\"\" style=\"max-width: 100%;color: rgb(51, 51, 51);\">\n<section  style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  class=\"\" style=\"max-width: 100%;line-height: 28.4444px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section  style=\"margin: 1em auto;max-width: 100%;border-width: 0px;border-style: none;border-color: initial;text-align: center;width: 941px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span class=\"\"  style=\"max-width: 100%;width: 941px;border-bottom: 1px solid rgb(172, 29, 16);border-top-color: rgb(172, 29, 16);border-right-color: rgb(172, 29, 16);border-left-color: rgb(172, 29, 16);display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/p>\n<section class=\"\" style=\"margin-bottom: -3px;padding-top: 5px;padding-right: 10px;padding-left: 10px;max-width: 100%;display: inline-block;min-height: 32px;border-bottom: 5px solid rgb(172, 29, 16);font-size: 20px;color: rgb(121, 121, 121);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-top: 5px;margin-bottom: 5px;max-width: 100%;min-height: 1em;line-height: 1.6em;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">End<\/p>\n<\/section>\n<p><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u53c2\u8003\u8d44\u6599\uff1a1\uff09<\/span><span style=\"font-size: 12px;\">New Lung Cell Identified<\/span><\/p>\n<p style=\"white-space: normal;text-align: justify;\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\">2\uff09Profile of an unknown airway cell<\/span><\/p>\n<section  class=\"\" style=\"max-width: 100%;box-sizing: border-box;letter-spacing: 0.544px;text-align: justify;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);line-height: 25.6px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-width: 0px;border-style: none;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"padding: 2px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: dotted;border-color: rgb(218, 98, 71);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin: 5px auto;max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;width: 50px;float: left;border-top: 2px solid rgb(172, 29, 16);border-right-color: rgb(172, 29, 16);border-bottom-color: rgb(172, 29, 16);border-left: 2px solid rgb(172, 29, 16);color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;display: inline-block;color: rgb(172, 29, 16);clear: both;border-color: rgb(172, 29, 16);word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<section class=\"\"  style=\"margin: -0.8em 0.3em;padding: 0.8em;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;color: inherit;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;overflow-wrap: break-word;color: rgb(51, 51, 51);font-size: 1em;line-height: 1.75em;word-break: break-all;box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"max-width: 100%;color: rgb(0, 0, 0);line-height: 22.4px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u672c\u6587\u7cfb\u751f\u7269\u63a2\u7d22\u539f\u521b\uff0c\u6b22\u8fce\u4e2a\u4eba\u8f6c\u53d1\u5206\u4eab\u3002\u5176\u4ed6\u4efb\u4f55\u5a92\u4f53\u3001\u7f51\u7ad9\u5982\u9700\u8f6c\u8f7d\uff0c\u987b\u5728\u6b63\u6587\u524d\u6ce8\u660e\u6765\u6e90\u751f\u7269\u63a2\u7d22\u3002<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;width: 50px;float: right;border-bottom: 2px solid rgb(172, 29, 16);border-top-color: rgb(172, 29, 16);border-right: 2px solid rgb(172, 29, 16);border-left-color: rgb(172, 29, 16);color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      width=\"auto\"  style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533788141.png\" alt=\"\u91cd\u78c5\uff01\u4e24\u7bc7Nature\u5171\u540c\u63ed\u793a\uff1a\u65b0\u578b\u80ba\u7ec6\u80de\" title=\"\u91cd\u78c5\uff01\u4e24\u7bc7Nature\u5171\u540c\u63ed\u793a\uff1a\u65b0\u578b\u80ba\u7ec6\u80de\"  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u751f\u7269\u63a2\u7d22                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u751f\u7269\u63a2\u7d22 \u7f16\u8005\u6309 8\u67081\u65e5\uff0c\u300aNature\u300b\u8fde\u53d1\u4e24\u7bc7\u6587\u7ae0\uff0c\u540c\u65f6\u63ed\u793a\u4e86\u4e00\u79cd\u65b0\u578b\u80ba\u7ec6\u80de\u2014\u2014\u201c\u80ba\u90e8\u79bb\u5b50\u7ec6\u80de\u201d\uff08pul [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":31357,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/31356"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=31356"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/31356\/revisions"}],"predecessor-version":[{"id":31367,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/31356\/revisions\/31367"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/31357"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=31356"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=31356"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=31356"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}