{"id":31581,"date":"2018-07-31T01:00:00","date_gmt":"2018-08-09T04:17:18","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/cell%e7%aa%81%e7%a0%b4%e6%88%90%e6%9e%9c%ef%bc%81%e5%89%91%e6%a1%a5%e7%a7%91%e5%ad%a6%e5%ae%b6%e6%99%ba%e6%93%92%e7%a3%b7%e9%85%b8%e9%85%b6%ef%bc%8c%e9%80%a0%e7%a6%8f%e7%bd%95\/"},"modified":"2018-08-09T12:17:20","modified_gmt":"2018-08-09T04:17:20","slug":"cell%e7%aa%81%e7%a0%b4%e6%88%90%e6%9e%9c%ef%bc%81%e5%89%91%e6%a1%a5%e7%a7%91%e5%ad%a6%e5%ae%b6%e6%99%ba%e6%93%92%e7%a3%b7%e9%85%b8%e9%85%b6%ef%bc%8c%e9%80%a0%e7%a6%8f%e7%bd%95","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/31581\/","title":{"rendered":"Cell\u7a81\u7834\u6210\u679c\uff01\u5251\u6865\u79d1\u5b66\u5bb6\u201c\u667a\u64d2\u201d\u78f7\u9178\u9176\uff0c\u9020\u798f\u7f55\u89c1\u75c5\u60a3\u8005"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"\" label=\"Copyright \u00a9 2015 Yead All Rights Reserved.\" style=\"max-width: 100%;color: rgb(51, 51, 51);\">\n<fieldset style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box;min-width: 0px;border-width: 0px;border-style: initial;border-color: initial;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-left: 5.51563px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: solid;border-color: rgb(197, 63, 70);border-radius: 0px 5px 5px 0px;font-size: 1em;font-family: inherit;text-align: inherit;text-decoration: inherit;color: rgb(52, 54, 60);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 27.2656px;margin-right: 8px;margin-left: -8px;max-width: 100%;box-sizing: border-box;float: left;font-size: 1em;font-family: inherit;font-style: inherit;text-decoration: inherit;color: rgb(255, 255, 255);border-color: rgb(197, 63, 70);word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span class=\"\" style=\"padding: 0.3em 0.5em;max-width: 100%;box-sizing: border-box;display: inline-block;border-radius: 0px 0.5em 0.5em 0px;font-size: 1em;font-family: inherit;background-color: rgb(197, 63, 70);word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u751f\u7269\u63a2\u7d22<\/section>\n<p><\/span><\/p>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;width: 0px;border-right: 4px solid rgb(197, 63, 70);border-top: 4px solid rgb(197, 63, 70);word-wrap: break-word !important;overflow-wrap: break-word !important;border-left: 4px solid transparent !important;border-bottom: 4px solid transparent !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: 27.2656px;padding-right: 8px;padding-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 1.5em;font-family: inherit;text-align: inherit;text-decoration: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u7f16\u8005\u6309<\/strong><\/span><\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;clear: both;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<section style=\"padding: 8px;max-width: 100%;box-sizing: border-box;line-height: 30px;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.75em;text-align: left;box-sizing: border-box !important;word-wrap: break-word !important;\">\u78f7\u9178\u9176\u5305\u62ec\u9178\u6027\u548c\u78b1\u6027\u4e24\u79cd\u3002\u533b\u751f\u53ef\u901a\u8fc7\u6d4b\u8bd5\u4f53\u5185\u8fd9\u4e24\u79cd\u9176\u68c0\u6d4b\u764c\u75c7\u7b49\u7279\u5b9a\u75be\u75c5\u3002\u5728\u4e4b\u524d\u7684\u836f\u6027\u7814\u7a76\u4e2d\uff0c\u78f7\u9178\u9176\u4e00\u76f4\u88ab\u8ba4\u4e3a\u4e0d\u5177\u6709\u6210\u836f\u6027\uff08undruggable\uff09\uff0c\u4f46\u8fd1\u65e5Cell\u4e00\u9879\u7814\u7a76\u79f0\uff0c\u79d1\u5b66\u5bb6\u4eec\u5f00\u53d1\u51fa\u4e86\u4e00\u79cd\u53ef\u9776\u5411\u78f7\u9178\u9176\u7684\u7cfb\u7edf\uff0c\u5e76\u5728\u5c0f\u9f20\u5b9e\u9a8c\u4e2d\u6210\u529f\u9a8c\u8bc1\u3002\u8fd9\u9879\u53d1\u73b0\u8ba9\u4ed6\u4eec\u6709\u673a\u4f1a\u7b5b\u9009\u51fa\u9776\u5411\u7279\u5b9a\u78f7\u9178\u9176\u7684\u836f\u7269\u3002<\/p>\n<\/section>\n<\/section>\n<\/fieldset>\n<\/section>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><img class=\"\"     style=\"border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533788239.png\" alt=\"Cell\u7a81\u7834\u6210\u679c\uff01\u5251\u6865\u79d1\u5b66\u5bb6\u201c\u667a\u64d2\u201d\u78f7\u9178\u9176\uff0c\u9020\u798f\u7f55\u89c1\u75c5\u60a3\u8005\" title=\"Cell\u7a81\u7834\u6210\u679c\uff01\u5251\u6865\u79d1\u5b66\u5bb6\u201c\u667a\u64d2\u201d\u78f7\u9178\u9176\uff0c\u9020\u798f\u7f55\u89c1\u75c5\u60a3\u8005\"  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u76f8\u5173\u7814\u7a76\u4e8e7\u670826\u65e5\u53d1\u8868\u5728\u300aCell\u300b\u6742\u5fd7\uff0c\u82f1\u56fd\u5251\u6865\u5206\u5b50\u751f\u7269\u5b66\u533b\u5b66\u7814\u7a76\u59d4\u5458\u4f1a\uff08MRC\uff09\u7684Anne Bertolotti\u535a\u58eb\u4e3a\u8bba\u6587\u901a\u8baf\u4f5c\u8005\u3002<\/p>\n<p><br  \/><\/p>\n<section class=\"\"  style=\"max-width: 100%;color: rgb(51, 51, 51);\">\n<section style=\"margin: 10px auto;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 3px;margin-left: 33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"margin-bottom: 10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span>&nbsp;&nbsp;&nbsp;<\/span><\/section>\n<section style=\"margin-top: -2px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: bottom;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<section style=\"max-width: 100%;display: inline-block;border-width: 1px;border-style: solid;border-color: rgb(255, 255, 255);width: 30px;height: 30px;line-height: 30px;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-right: auto;margin-left: auto;max-width: 100%;min-height: 1em;white-space: pre-wrap;min-width: 1px;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">01<\/p>\n<\/section>\n<section style=\"max-width: 100%;display: inline-block;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: 3px;margin-left: -33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span><span style=\"margin-bottom: -10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span>&nbsp; &nbsp;<\/span><\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(123, 12, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6700\u65b0\u7814\u7a76<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(123, 12, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><strong>\u78f7\u9178\u9176<\/strong>\u662f\u7ec6\u80de\u4fe1\u53f7\u4f20\u9012\uff08\u5f00\u542f\u6216\u5173\u95ed\uff09\u7684\u5173\u952e\u90e8\u5206\u3002\u5927\u591a\u6570\u4fe1\u53f7\u90fd\u662f\u4ece\u6fc0\u6d3b\u4fe1\u53f7\u5f00\u59cb\u7684\u2014\u2014\u901a\u5e38\u8d77\u59cb\u4e8e\u4e00\u79cd\u6fc0\u9176\u628a\u4e00\u4e2a\u5316\u5b66\u6807\u8bb0\uff08\u78f7\u9178\u57fa\u56e2\uff09\u9644\u7740\u5728\u7279\u5b9a\u7684\u86cb\u767d\u8d28\u4e0a\uff0c\u4ece\u800c\u6539\u53d8\u5b83\u4eec\u7684\u529f\u80fd\u3002\u800c\u78f7\u9178\u9176\u4f1a\u5207\u65ad\u8fd9\u4e00\u4fe1\u53f7\uff08\u963b\u6b62\u78f7\u9178\u57fa\u56e2\u6807\u8bb0\uff09\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u7ec6\u80de\u4e2d\u6709200\u591a\u79cd\u78f7\u9178\u9176\u53c2\u4e0e\u8bb8\u591a\u4e0d\u540c\u7684\u8fc7\u7a0b\uff0c\u56e0\u6b64\u4efb\u4f55\u836f\u7269\u90fd\u5fc5\u987b\u9009\u62e9\u6027\u5730\u53ea\u9488\u5bf9\u6b63\u786e\u7684\u4e00\u79cd\uff0c\u5426\u5219\u4f1a\u4ea7\u751f\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u6216\u6740\u6b7b\u7ec6\u80de\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u80fd\u591f\u9776\u5411\u7279\u5b9a\u6fc0\u9176\u7684\u836f\u7269\uff08\u4f8b\u5982\u6297\u764c\u836f\u7269\uff09\u5df2\u7ecf\u5148\u540e\u88ab\u5f00\u53d1\u51fa\u6765\uff0c\u4f46\u662f\u7279\u5f02\u6027\u9776\u5411\u78f7\u9178\u9176\u7684\u836f\u7269\u5374\u5f88\u8270\u96be\u2014\u2014\u56e0\u4e3a\u5207\u65ad\u78f7\u9178\u57fa\u56e2\u7684\u529f\u80fd\u662f\u6240\u6709\u78f7\u9178\u9176\u5171\u6709\u7684\uff0c\u6240\u4ee5\u5bf9\u4e00\u79cd\u78f7\u9178\u9176\u7ed9\u836f\u4f1a\u6291\u5236\u6570\u767e\u79cd\u78f7\u9178\u9176\u5e76\u6740\u6b7b\u7ec6\u80de\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u9886\u5bfc\u8fd9\u9879\u7814\u7a76\u7684Bertolotti\u535a\u58eb\u8bf4\uff1a\u201c\u51e0\u5341\u5e74\u6765\uff0c\u7531\u4e8e\u6ca1\u6709\u529e\u6cd5\u9009\u62e9\u6027\u5730\u9776\u5411\u78f7\u9178\u9176\uff0c\u79d1\u5b66\u5bb6\u4eec\u5bf9\u5b83\u4eec\u7684\u7814\u7a76\u5df2\u7ecf\u843d\u540e\u4e8e\u6fc0\u9176\uff0c\u8fd9\u4e5f\u5bfc\u81f4\u5b83\u4eec\u88ab\u8ba4\u4e3a\u662f\u4e0d\u5177\u6709\u6210\u836f\u6027\u7684\u3002\u6211\u4eec\u7684\u65b0\u7cfb\u7edf\u4ec5\u4ec5\u662f\u521d\u6b65\u7814\u7a76\uff0c\u4f46\u6211\u4eec\u5e0c\u671b\u5bf9\u76f8\u5173\u95ee\u9898\u7684\u7834\u89e3\u53ef\u4fc3\u8fdb\u78f7\u9178\u9176\u5730\u6df1\u5165\u7814\u7a76\u4ee5\u53ca\u836f\u7269\u5f00\u53d1\u3002\u201d<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u201c\u9776\u5411\u78f7\u9178\u9176\u800c\u975e\u6fc0\u9176\u5c31\u50cf\u7784\u51c6\u7ec6\u80de\u4fe1\u53f7\u4e0a\u7684\u5239\u8f66\u800c\u4e0d\u662f\u52a0\u901f\u5668\u4e00\u6837\uff0c\u901a\u8fc7\u6291\u5236\u78f7\u9178\u9176\uff0c\u6211\u4eec\u5ef6\u957f\u4e86\u5df2\u7ecf\u88ab\u6fc0\u6d3b\u7684\u4fe1\u53f7\u4e8b\u4ef6\uff0c\u8fd9\u6709\u671b\u4ee5\u66f4\u5b89\u5168\u7684\u65b9\u6cd5\u6765\u7279\u5f02\u6027\u6539\u53d8\u7ec6\u80de\u4e2d\u7684\u4fe1\u53f7\uff0c\u5e76\u6709\u52a9\u4e8e\u521b\u9020\u526f\u4f5c\u7528\u66f4\u5c11\u7684\u65b0\u836f\u3002\u201d<\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;\">\n<p style=\"text-align: center;line-height: 1.75em;\"><span style=\"color: rgb(136, 136, 136);\">Huntingtin protein (green) accumulated in the cells from the brains of mice given a placebo. Credit: Krzyzosiak et al.\/ Cell<\/span><\/p>\n<p><br  \/><\/p>\n<section class=\"\"  style=\"max-width: 100%;color: rgb(51, 51, 51);\">\n<section style=\"margin: 10px auto;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 3px;margin-left: 33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"margin-bottom: 10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span>&nbsp;&nbsp;&nbsp;<\/span><\/section>\n<section style=\"margin-top: -2px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: bottom;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<section style=\"max-width: 100%;display: inline-block;border-width: 1px;border-style: solid;border-color: rgb(255, 255, 255);width: 30px;height: 30px;line-height: 30px;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-right: auto;margin-left: auto;max-width: 100%;min-height: 1em;white-space: pre-wrap;min-width: 1px;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">02<\/p>\n<\/section>\n<section style=\"max-width: 100%;display: inline-block;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: 3px;margin-left: -33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span><span style=\"margin-bottom: -10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span>&nbsp; &nbsp;<\/span><\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(123, 12, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4ea8\u5ef7\u987f\u6c0f\u75c5\u60a3\u8005\u798f\u97f3<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(123, 12, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u7814\u7a76\u4eba\u5458\u968f\u540e\u5728\u9274\u5b9a\u8be5\u7cfb\u7edf\u65f6\u6210\u529f\u53d1\u73b0\u4e86\u4e00\u79cd\u5728\u4ea8\u5ef7\u987f\u6c0f\u75c5\u5c0f\u9f20\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u5e0c\u671b\u7684\u5206\u5b50\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u4ea8\u5ef7\u987f\u6c0f\u75c5\uff0c\u53c8\u79f0\u4ea8\u5ef7\u987f\u6c0f\u821e\u8e48\u75c7\uff08Huntington\u2019s disease, HD\uff09\u662f\u4e00\u79cd\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u60a3\u8005\u4e00\u822c\u5728\u4e2d\u5e74\u53d1\u75c5\uff0c\u51fa\u73b0\u8fd0\u52a8\u3001\u8ba4\u77e5\u548c\u7cbe\u795e\u65b9\u9762\u7684\u75c7\u72b6\u3002\u5176\u4e34\u5e8a\u75c7\u72b6\u590d\u6742\u591a\u53d8\uff0c\u60a3\u8005\u75c5\u60c5\u5448\u8fdb\u884c\u6027\u6076\u5316\uff0c\u901a\u5e38\u5728\u53d1\u75c515\uff5e20\u5e74\u540e\u6b7b\u4ea1\u30022018\u5e745\u670811\u65e5\uff0c\u56fd\u5bb6\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u7b495\u90e8\u95e8\u8054\u5408\u5236\u5b9a\u4e86\u300a\u7b2c\u4e00\u6279\u7f55\u89c1\u75c5\u76ee\u5f55\u300b\uff0c\u4ea8\u5ef7\u987f\u6c0f\u821e\u8e48\u75c7\u88ab\u6536\u5f55\u5176\u4e2d\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u4ea8\u5ef7\u987f\u6c0f\u75c5\u4e0e\u963f\u5c14\u8328\u6d77\u9ed8\u6c0f\u75c5\u3001\u5e15\u91d1\u68ee\u6c0f\u75c5\u7b49\u75be\u75c5\u4e00\u6837\uff0c\u90fd<strong>\u4ee5\u79ef\u805a\u5728\u5927\u8111\u7ec6\u80de\u4e2d\u9519\u8bef\u6298\u53e0\u7684\u86cb\u767d\u8d28\u4e3a\u7279\u5f81\u3002<\/strong>\u7814\u7a76\u4eba\u5458\u5e0c\u671b\u901a\u8fc7\u51cf\u7f13\u7ec6\u80de\u86cb\u767d\u8d28\u7684\u4ea7\u751f\u901f\u5ea6\u4ee5\u786e\u4fdd\u5b83\u7684\u201c\u8d28\u91cf\u63a7\u5236\u673a\u5236\u201d\uff08quality control machinery\uff09\u6709\u66f4\u5927\u7684\u80fd\u529b\u6765\u6e05\u9664\u9519\u8bef\u6298\u53e0\u7684\u86cb\u767d\u8d28\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u4ed6\u4eec\u65e8\u5728\u901a\u8fc7\u9776\u5411\u4e00\u79cd\u7279\u5b9a\u78f7\u9178\u9176<strong>PPP1R15B<\/strong>\u6765\u51cf\u7f13\u7ec6\u80de\u5185\u86cb\u767d\u8d28\u4ea7\u751f\u673a\u5236\u3002\u4f7f\u7528\u65b0\u7684\u836f\u7269\u53d1\u73b0\u5e73\u53f0\uff0c\u4ed6\u4eec\u627e\u5230\u4e86\u4e00\u79cd\u53ea\u9488\u5bf9\u78f7\u9178\u9176\u7684\u3001\u53eb\u505a<strong>Raphin1<\/strong>\u7684\u5206\u5b50\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u5f53\u7814\u7a76\u4eba\u5458\u5728\u4ea8\u5ef7\u987f\u6c0f\u75c5\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\u6d4b\u8bd5Raphin1\u65f6\uff0c\u4ed6\u4eec\u53d1\u73b0Raphin1\u53ef\u4ee5\u8fdb\u5165\u5927\u8111\uff0c\u4ece\u800c\u51cf\u5c11\u75be\u75c5\u76f8\u5173\u7684\u9519\u8bef\u6298\u53e0\u86cb\u767d\u5728\u795e\u7ecf\u5143\u4e2d\u7684\u79ef\u7d2f\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u9700\u8981\u6307\u51fa\u7684\u662f\uff0c\u79d1\u5b66\u5bb6\u5f3a\u8c03\u8fd9\u662f\u65e9\u671f\u7814\u7a76\uff0c\u8fd8\u9700\u505a\u66f4\u591a\u7684\u5de5\u4f5c\u6765\u6d4b\u8bd5\u8fd9\u79cd\u836f\u7269\u5bf9\u4eba\u4f53\u662f\u5426\u5b89\u5168\u6216\u6709\u6548\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;\">\u201c\u4ea8\u5ef7\u987f\u6c0f\u75c5\u662f\u9057\u4f20\u6027\u75be\u75c5\uff0c\u65e9\u671f\u57fa\u56e0\u8bca\u65ad\u53ef\u4ee5\u4e3a\u6211\u4eec\u63d0\u4f9b\u6cbb\u7597\u7684\u5e0c\u671b\uff0c\u4ece\u800c\u5728\u75c7\u72b6\u51fa\u73b0\u4e4b\u524d\u9776\u5411\u8fd9\u79cd\u75be\u75c5\u3002\u6211\u4eec\u65b9\u6cd5\u7684\u72ec\u7279\u4e4b\u5904\u5728\u4e8e\u64cd\u7eb5\u7ec6\u80de\u51cf\u6162\u6b63\u5e38\u529f\u80fd\uff0c\u5e76\u63d0\u4f9b\u7ed9\u7ec6\u80de\u6e05\u9664\u4ea8\u5ef7\u987f\u6c0f\u75c7\u7279\u6709\u7684\u9519\u8bef\u6298\u53e0\u86cb\u767d\u8d28\u7684\u673a\u4f1a\u3002\u4e0d\u8fc7\uff0c\u6211\u4eec\u5c1a\u9700\u51e0\u5e74\u65f6\u95f4\u624d\u80fd\u77e5\u9053\u8fd9\u79cd\u65b9\u6cd5\u662f\u5426\u5bf9\u4eba\u7c7b\u6709\u6548\u4e14\u5b89\u5168\u3002\u201dBertolotti\u535a\u58eb\u603b\u7ed3\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: right;line-height: 1.75em;\"><strong>\u8d23\u7f16\uff1a\u6d6e\u82cf<\/strong><\/p>\n<section  class=\"\" style=\"max-width: 100%;color: rgb(51, 51, 51);\">\n<section  style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  class=\"\" style=\"max-width: 100%;line-height: 28.4444px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section  style=\"margin: 1em auto;max-width: 100%;border-width: 0px;border-style: none;border-color: initial;text-align: center;width: 941px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span class=\"\"  style=\"max-width: 100%;width: 941px;border-bottom: 1px solid rgb(172, 29, 16);border-top-color: rgb(172, 29, 16);border-right-color: rgb(172, 29, 16);border-left-color: rgb(172, 29, 16);display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/p>\n<section class=\"\" style=\"margin-bottom: -3px;padding-top: 5px;padding-right: 10px;padding-left: 10px;max-width: 100%;display: inline-block;min-height: 32px;border-bottom: 5px solid rgb(172, 29, 16);font-size: 20px;color: rgb(121, 121, 121);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-top: 5px;margin-bottom: 5px;max-width: 100%;min-height: 1em;line-height: 1.6em;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">End<\/p>\n<\/section>\n<p><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><strong class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/strong><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\">1\uff09<span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"text-align: justify;\">New system can identify drugs to target &#8216;undruggable&#8217; enzymes critical in many diseases<\/span><\/span><\/span><\/p>\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<section  class=\"\" style=\"max-width: 100%;box-sizing: border-box;letter-spacing: 0.544px;text-align: justify;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);line-height: 25.6px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-width: 0px;border-style: none;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"padding: 2px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: dotted;border-color: rgb(218, 98, 71);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin: 5px auto;max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;width: 50px;float: left;border-top: 2px solid rgb(172, 29, 16);border-right-color: rgb(172, 29, 16);border-bottom-color: rgb(172, 29, 16);border-left: 2px solid rgb(172, 29, 16);color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;display: inline-block;color: rgb(172, 29, 16);clear: both;border-color: rgb(172, 29, 16);word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<section class=\"\"  style=\"margin: -0.8em 0.3em;padding: 0.8em;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;color: inherit;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;overflow-wrap: break-word;color: rgb(51, 51, 51);font-size: 1em;line-height: 1.75em;word-break: break-all;box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"max-width: 100%;color: rgb(0, 0, 0);line-height: 22.4px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u672c\u6587\u7cfb\u751f\u7269\u63a2\u7d22\u539f\u521b\uff0c\u6b22\u8fce\u4e2a\u4eba\u8f6c\u53d1\u5206\u4eab\u3002\u5176\u4ed6\u4efb\u4f55\u5a92\u4f53\u3001\u7f51\u7ad9\u5982\u9700\u8f6c\u8f7d\uff0c\u987b\u5728\u6b63\u6587\u524d\u6ce8\u660e\u6765\u6e90\u751f\u7269\u63a2\u7d22\u3002<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;width: 50px;float: right;border-bottom: 2px solid rgb(172, 29, 16);border-top-color: rgb(172, 29, 16);border-right: 2px solid rgb(172, 29, 16);border-left-color: rgb(172, 29, 16);color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);\"><img class=\"\"      width=\"auto\"  style=\"box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress6-1533788239.png\" alt=\"Cell\u7a81\u7834\u6210\u679c\uff01\u5251\u6865\u79d1\u5b66\u5bb6\u201c\u667a\u64d2\u201d\u78f7\u9178\u9176\uff0c\u9020\u798f\u7f55\u89c1\u75c5\u60a3\u8005\" title=\"Cell\u7a81\u7834\u6210\u679c\uff01\u5251\u6865\u79d1\u5b66\u5bb6\u201c\u667a\u64d2\u201d\u78f7\u9178\u9176\uff0c\u9020\u798f\u7f55\u89c1\u75c5\u60a3\u8005\"  \/><\/p>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u751f\u7269\u63a2\u7d22                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u751f\u7269\u63a2\u7d22 \u7f16\u8005\u6309 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[&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":31582,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/31581"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=31581"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/31581\/revisions"}],"predecessor-version":[{"id":31590,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/31581\/revisions\/31590"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/31582"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=31581"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=31581"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=31581"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}