{"id":31734,"date":"2018-08-05T01:00:00","date_gmt":"2018-08-09T04:18:19","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e6%8e%a8%e5%8a%a8%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97-2018-%e7%ac%ac%e5%9b%9b%e5%b1%8a%e4%b8%8b%e4%b8%80%e4%bb%a3car-tcr-t%e7%a0%94%e8%ae%a8%e4%bc%9a\/"},"modified":"2018-08-09T12:18:22","modified_gmt":"2018-08-09T04:18:22","slug":"%e6%8e%a8%e5%8a%a8%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97-2018-%e7%ac%ac%e5%9b%9b%e5%b1%8a%e4%b8%8b%e4%b8%80%e4%bb%a3car-tcr-t%e7%a0%94%e8%ae%a8%e4%bc%9a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/31734\/","title":{"rendered":"\u63a8\u52a8\u7ec6\u80de\u6cbb\u7597\u20142018 (\u7b2c\u56db\u5c4a)\u4e0b\u4e00\u4ee3CAR & TCR-T\u7814\u8ba8\u4f1a"},"content":{"rendered":"
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2017\u5e74\u6210\u4e3aCAR-T\u6280\u672f\u7684\u6807\u5fd7\u6027\u5143\u5e74——FDA\u5148\u540e\u6279\u51c6\u4e24\u6b3eCAR-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1Kymriah\u548cYescarta\u4e0a\u5e02\uff0c \u5f00\u542f\u4e86\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u65b0\u65f6\u4ee3\u3002\u5728\u6b64\u63a8\u52a8\u4e0b\uff0c\u6211\u56fd\u4e5f\u5148\u540e\u51fa\u53f0\u4e86\u4e24\u9879\u91cd\u8981\u653f\u7b56\uff0c\u4e00\u4e2a\u662f2017\u5e7412\u6708\uff0c \u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u7ec4\u7ec7\u5236\u5b9a\u4e86\u300a\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u7814\u7a76\u4e0e\u8bc4\u4ef7\u6280\u672f\u6307\u5bfc\u539f\u5219\uff08\u8bd5\u884c\uff09\u300b\uff0c \u53e6\u4e00\u4e2a\u662f2018\u5e746\u6708\uff0c\u4e2d\u56fd\u98df\u54c1\u836f\u54c1\u68c0\u5b9a\u7814\u7a76\u9662\u53d1\u5e03\u4e86\u5173\u4e8e\u300aCAR-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u8d28\u91cf\u63a7\u5236\u68c0\u6d4b\u7814\u7a76\u53ca\u975e\u4e34\u5e8a\u7814\u7a76\u8003\u8651\u8981\u70b9\u300b\u7684\u901a\u77e5\uff0c \u4e3a\u6211\u56fdCAR-T\u7ec6\u80de\u4ea7\u54c1\u7684\u8d28\u91cf\u63a7\u5236\u7814\u7a76\u53ca\u975e\u4e34\u5e8a\u8bc4\u4ef7\u7814\u7a76\u63d0\u4f9b\u66f4\u52a0\u5177\u4f53\u7684\u6280\u672f\u6307\u5bfc\uff0c\u4ece\u800c\u4f7f\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u8d70\u4e0a\u4e86\u66f4\u52a0\u4e25\u683c\u7684\u89c4\u8303\u5316\u9053\u8def\uff0c \u5e76\u4e0e\u56fd\u9645\u63a5\u8f68\u3002<\/span><\/p>\n


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\u8d8a\u6765\u8d8a\u591a\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u8bc1\u5b9e\u4e86CAR-T\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u7684\u6548\u529b, \u7279\u522b\u662f\u8840\u6db2\u75c5\u65b9\u9762, \u5982\u767d\u8840\u75c5, \u6dcb\u5df4\u7624\u3002\u800c\u5728\u5b9e\u4f53\u7624\u7684\u6cbb\u7597\u65b9\u9762\u4ecd\u9700\u8981\u4e0d\u65ad\u52aa\u529b\u3002\u6b64\u5916\uff0c\u65b0\u578b\u7684CAR-T\u6280\u672f\u4e5f\u4e0d\u65ad\u6d8c\u73b0\uff0c \u5982\u53cc\u7279\u5f02CAR, \u901a\u7528CAR\u7b49\u3002\u4e34\u5e8a\u533b\u751f\u548c\u751f\u7269\u6280\u672f\u516c\u53f8\u4e5f\u5728\u4e0d\u65ad\u79ef\u6781\u63a8\u52a8CAR-T\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u8d70\u5411\u4e34\u5e8a\u5e94\u7528\u3002\u76ee\u524d\u4e2d\u56fd\u662f\u4e16\u754c\u4e0a\u7533\u8bf7\u7ec6\u80de\u6cbb\u7597\u4e34\u5e8a\u8bd5\u9a8c\u4ec5\u6b21\u4e8e\u7f8e\u56fd\u7684\u56fd\u5bb6\u3002<\/span><\/p>\n


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\u9664\u4e86CAR-T, TCR-T, CAR-NK\u7b49\u65b0\u578b\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u4e5f\u6b63\u5728\u5f00\u53d1\u4e2d\u3002\u4e3a\u6b64\uff0c\u751f\u7269\u8c37\u5c06\u5728\u4e0a\u6d77\u9686\u91cd\u4e3e\u529e<\/span>2018\uff08\u7b2c\u56db\u5c4a\uff09\u4e0b\u4e00\u4ee3CAR-T & TCR-T\u7814\u8ba8\u4f1a<\/span>\uff0c \u9080\u8bf7\u56fd\u5185\u5916\u77e5\u540d\u7684\u4e13\u5bb6\uff0c\u5b66\u8005\uff0c\u4e34\u5e8a\u533b\u751f\u5ea7\u8c08\uff0c\u63a8\u52a8\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u6280\u672f\u7684\u4e34\u5e8a\u5e94\u7528\u53ca\u89c4\u8303\u5316\u6cbb\u7597\u3002\u540c\u671f\u4f1a\u7279\u4e3e\u529e<\/span>\u81ea\u52a8\u5316\u7ec6\u80de\u57f9\u517b\u4e3b\u9898\u6c99\u9f99<\/span>\u548c<\/span>CAR-T \u7ec6\u80de\u6cbb\u7597\u7684CDMO\u6a21\u5f0f\u4e3b\u9898\u6c99\u9f99\u3002<\/span><\/span><\/p>\n


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\u4f1a\u8bae\u5b89\u6392\uff1a<\/span><\/strong><\/p>\n


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\u4f1a\u8bae\u65f6\u95f4\uff1a11\u670823\u65e5\uff0d24\u65e5<\/span><\/p>\n

\u4f1a\u8bae\u5730\u70b9\uff1a\u4e0a\u6d77<\/span><\/p>\n

\u4e3b\u529e\u5355\u4f4d\uff1a\u751f\u7269\u8c37\uff08\u4e0a\u6d77\u6625\u8c37\u751f\u7269\u533b\u836f\u79d1\u6280\u6709\u9650\u516c\u53f8\uff09<\/span><\/p>\n

\u4f1a\u8bae\u5f62\u5f0f\uff1a\u4e00\u4e2a\u4f1a\u8bae+ \u4e8c\u4e2a\u6c99\u9f99+\u5c55\u89c8\u5c55\u793a<\/span><\/p>\n

\u4f1a\u8bae\u89c4\u6a21\uff1a400\u4eba<\/span><\/p>\n


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\u4f1a\u8bae\u4eae\u70b9\uff1a<\/span><\/p>\n


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1. <\/span>\u4e0e\u4e13\u5bb6\u8ba8\u8bbaCAR-T, \u5230TCR-T, NK\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u6280\u672f\u5728\u79d1\u7814\u548c\u5e94\u7528\u9886\u57df\u7684\u95ee\u9898\uff1b      <\/span><\/span><\/p>\n

2.\u6700\u65b0\u7684\u7ec6\u80de\u6cbb\u7597\u653f\u7b56\u89e3\u8bfb\uff0c\u4f7f\u7ec6\u80de\u6cbb\u7597\u4f01\u4e1a\u6709\u201c\u89c4\u201d\u53ef\u5faa\uff1b<\/span><\/p>\n

3.\u63a8\u52a8\u4e34\u5e8a\u7814\u7a76\uff0c\u5982\u4f55\u63d0\u9ad8\u5b89\u5168\u6027\u662f\u91cd\u70b9\u3002<\/span><\/p>\n


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\u4f1a\u8bae\u8ba8\u8bba\u91cd\u70b9<\/span><\/p>\n


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\u8ba8\u8bba\u95ee\u9898<\/span><\/p>\n


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\u4f1a\u8bae\u5e72\u8d27\u4e4b\u4e00<\/span><\/p>\n


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1.CART\u5b89\u5168\u95ee\u9898\u4f9d\u7136\u5b58\u5728\uff0c \u4e3b\u8981\u662f\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4 (Cytokine storm release, CSR)\u3001\u8131\u9776\u548c\u795e\u7ecf\u6bd2\u6027<\/span><\/p>\n<\/td>\n

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1.\u8bbe\u8ba1\u5e26\u5b89\u5168\u5f00\u5173\u7684CAR-T<\/span><\/p>\n<\/td>\n<\/tr>\n

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2.\u5b9e\u4f53\u7624\u6cbb\u7597\u6ca1\u6709\u53d6\u5f97\u6709\u6548\u7684\u4e34\u5e8a\u8fdb\u5c55<\/span><\/p>\n<\/td>\n

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2.\u9009\u62e9\u80bf\u7624\u65b0\u6297\u539f; TCR-T; NK<\/span><\/p>\n<\/td>\n<\/tr>\n

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3.\u75be\u75c5\u590d\u53d1\u7387\u6bd4\u8f83\u9ad8<\/span><\/p>\n<\/td>\n

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3.\u53cc\u80bf\u7624\u6297\u539fCAR-T<\/span><\/p>\n<\/td>\n<\/tr>\n

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4.T\u7ec6\u80de\u751f\u4ea7\u6210\u672c\u9ad8<\/span><\/p>\n<\/td>\n

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4.\u901a\u7528CAR-T; \u6539\u8fdb\u751f\u4ea7\u5de5\u827a<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n


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\u4f1a\u8bae\u8bae\u9898\uff1a<\/span><\/p>\n


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\"\u63a8\u52a8\u7ec6\u80de\u6cbb\u7597\u20142018<\/p>\n


<\/p>\n

\u5df2\u786e\u8ba4\u5609\u5bbe\uff1a<\/span><\/p>\n

\"\u63a8\u52a8\u7ec6\u80de\u6cbb\u7597\u20142018<\/p>\n


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\u62df\u9080\u5609\u5bbe\uff08\u6392\u540d\u4e0d\u5206\u5148\u540e\uff09<\/span><\/p>\n

\"\u63a8\u52a8\u7ec6\u80de\u6cbb\u7597\u20142018<\/p>\n


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\u53c2\u4f1a\u53ca\u5a92\u4f53\u5408\u4f5c\uff1a<\/span><\/p>\n

\u59da\u6bc5<\/span><\/p>\n

Mt: 17321087523<\/span>
E-mail\uff1ayi.yao@bioon.com<\/span><\/span><\/p>\n


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\u4e0a\u6d77\u7ad9|\u836f\u54c1\u751f\u4ea7\u5de5\u827a\u53d8\u66f4\u7814\u7a76\u53ca\u5de5\u827a\u53d8\u66f4\u9a8c\u8bc1\u5b9e\u65bd<\/strong><\/a><\/p>\n

\u57f9\u8bad\u901a\u77e5|2018 CFDA\u300a\u836f\u54c1\u6570\u636e\u7ba1\u7406\u89c4\u8303\u300b\u89e3\u8bfb\u4e0e\u6848\u4f8b\u89e3\u6790<\/strong><\/a><\/p>\n

\u6210\u90fd\u7ad9|\u57fa\u4e8e\u98ce\u9669\u548c\u8bbe\u8ba1\u7684\u836f\u54c1\u65e0\u83cc\u4fdd\u8bc1\u63aa\u65bd\uff08\u7b2c\u4e00\u671f\uff09<\/strong><\/a><\/p>\n

\u6297\u4f53\u836f\u7814\u53d1\u73b0\u72b6\u53ca\u7acb\u9879\u89e3\u6790\uff08\u7b2c\u4e00\u671f\uff09<\/span><\/strong><\/a><\/h2>\n<\/section>\n
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\u4e25\u6b63\u58f0\u660e<\/strong>
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\u672c\u6587\u8f6c\u8f7d\u4e8e\u751f\u7269\u8c37\uff0c\u65e8\u5728\u77e5\u8bc6\u5171\u4eab\uff0c\u65e0\u4efb\u4f55\u5546\u4e1a\u7528\u9014\uff0c\u5982\u6d89\u53ca\u4fb5\u6743\u8bf7\u53ca\u65f6\u8054\u7cfb\u5c0f\u7f16<\/span><\/p>\n

tinorl@163.com<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u63a8\u52a8\u7ec6\u80de\u6cbb\u7597\u20142018<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u836f\u65f6\u7a7a <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

2017\u5e74\u6210\u4e3aCAR-T\u6280\u672f\u7684\u6807\u5fd7\u6027\u5143\u5e74——FDA\u5148\u540e\u6279\u51c6\u4e24\u6b3eCAR-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1K […]<\/p>\n","protected":false},"author":1,"featured_media":31735,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/31734"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=31734"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/31734\/revisions"}],"predecessor-version":[{"id":31746,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/31734\/revisions\/31746"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/31735"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=31734"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=31734"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=31734"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}