{"id":32214,"date":"2018-08-07T01:00:00","date_gmt":"2018-08-09T04:21:30","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/08\/09\/%e7%ac%ac%e4%ba%8c%e4%bb%a3pd-1%e6%8a%97%e4%bd%93%e6%a8%aa%e7%a9%ba%e5%87%ba%e4%b8%96%ef%bc%8c%e9%a3%8e%e5%8d%8e%e5%88%9d%e7%8e%b0%ef%bc%81\/"},"modified":"2018-08-09T12:21:33","modified_gmt":"2018-08-09T04:21:33","slug":"%e7%ac%ac%e4%ba%8c%e4%bb%a3pd-1%e6%8a%97%e4%bd%93%e6%a8%aa%e7%a9%ba%e5%87%ba%e4%b8%96%ef%bc%8c%e9%a3%8e%e5%8d%8e%e5%88%9d%e7%8e%b0%ef%bc%81","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/32214\/","title":{"rendered":"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section style=\"font-size: 15px;line-height: 2;letter-spacing: 0.5px;padding: 0px 20px;color: rgb(86, 86, 102);box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;border-width: 0px;border-radius: 5px;border-style: none;border-color: rgb(86, 86, 102);overflow: hidden;box-sizing: border-box;\"><img    style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"  src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress4-1533788490.jpeg\" alt=\"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01\" title=\"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"color: rgb(86, 86, 102);box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><span style=\"font-size: 13px;box-sizing: 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border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u5982\u4eca\uff0c\u4ee5<span style=\"color: rgb(68, 135, 180);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"> <\/strong><strong style=\"box-sizing: border-box;\">PD-1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242<\/strong><\/span><span style=\"color: rgb(64, 105, 131);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"> 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style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u4eca\u5929\u5c0f\u7f16\u8981\u804a\u5230\u7684\u65b0\u836f\uff0c\u5c31\u662f\u5728 <span style=\"color: rgb(68, 135, 180);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u514b\u670dPD-1\u6cbb\u7597\u8010\u836f\u7684\u7814\u7a76<\/strong><\/span><strong style=\"box-sizing: border-box;\">&nbsp;<\/strong>\u4e2d\u53d1\u73b0\u7684\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u8fd9\u4e2a\u95ee\u9898\u7684\u5f15\u51fa\u6765\u81ea\u4e8eTGF-\u03b2\uff0c\u4e00\u4e2aPD-1\/PD-L1\u901a\u8def\u4ee5\u5916\u7684\u80bf\u7624\u7ec6\u80de\u201c\u514d\u75ab\u9003\u9038\u201d\u9014\u5f84\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  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border-box;\">\uff08\u56fe1\uff09<\/span>\uff0c\u662f\u4e0d\u662f\u5c31\u53ef\u4ee5\u63d0\u9ad8PD-1\u514d\u75ab\u7597\u6cd5\u7684\u6548\u7387\uff0c\u6216\u8005\u53ef\u4ee5\u514b\u670d\u80bf\u7624\u7ec6\u80de\u5bf9PD-1\u6cbb\u7597\u7684\u8010\u836f\uff1f<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img    style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"  src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress10-1533788490.jpg\" alt=\"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01\" title=\"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"color: rgb(86, 86, 102);text-align: center;box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><span style=\"font-size: 12px;box-sizing: border-box;\">\u56fe1&nbsp; \u8054\u5408\u963b\u65adTGF-\u03b2\u548c\u6297PD-L1\u53ef\u9006\u8f6c\u80bf\u7624\u514d\u75ab\u9003\u9038<\/span><\/p>\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u6709\u601d\u8def\u5c31\u6709\u529e\u6cd5\uff0c\u8fd9\u4e0d\uff0c\u56fd\u5bb6\u80bf\u7624\u7814\u7a76\u4e2d\u5fc3<span style=\"color: rgb(142, 142, 154);box-sizing: border-box;\">\uff08NCI\uff09<\/span>\u548c\u7ea6\u7ff0\u00b7\u970d\u666e\u91d1\u65af\u533b\u5b66\u9662<span style=\"color: rgb(142, 142, 154);box-sizing: border-box;\">\uff08JHMI\uff09<\/span>\u4e24\u7ec4\u72ec\u7acb\u5de5\u4f5c\u7684\u7814\u7a76\u4eba\u5458\u5c31\u5f00\u53d1\u51fa\u4e00\u79cd\u836f\u7269\uff0c<span style=\"color: rgb(68, 135, 180);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u5c06TGF-\u03b2\u7684\u86cb\u767d\u8d28\u53d7\u4f53\u4e0e\u9488\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u86cb\u767d\u8d28\u7684\u6297\u4f53<\/strong><\/span><span style=\"color: rgb(142, 142, 154);box-sizing: border-box;\">\uff08\u4f8b\u5982PD-L1\u6216CTLA-4\uff09<\/span><span style=\"color: rgb(68, 135, 180);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u878d\u5408\u6765\u521b\u5efa\u836f\u7269<\/strong><\/span>\uff0c\u4ed6\u4eec\u5c06\u8fd9\u79cd\u5408\u6210\u65b9\u6cd5\u547d\u540d\u4e3aY-trap\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin: 10px 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;padding: 0px 10px;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: left;font-size: 18px;color: rgb(68, 135, 180);box-sizing: border-box;\">\n<p style=\"text-align: center;margin: 0px;padding: 0px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">02<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;box-shadow: rgb(0, 0, 0) 0px 0px 0px;border-top: 1px solid rgb(62, 62, 62);border-top-left-radius: 0px;padding: 0px 10px;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin: 10px 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"margin-bottom: -6px;line-height: 1em;padding: 0px 5px;font-size: 17px;letter-spacing: 1px;box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\">M7824\u521d\u9732\u950b\u8292<\/p>\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<section style=\"width: 100%;height: 10px;background-color: rgba(68, 135, 180, 0.15);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u5fb7\u56fd\u9ed8\u514b\u516c\u53f8\u83b7\u5f97\u4e86Y-trap\u7684\u7814\u53d1\u6743\u76ca\uff0c\u5e76\u7ee7\u7eed\u63a8\u8fdb\u7814\u53d1\uff0c<span style=\"color: rgb(68, 135, 180);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u4ed6\u4eec\u5c06\u8fd9\u79cd\u836f\u7269\u547d\u540d\u4e3aM7824\u3002<\/strong><\/span><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u5b83\u6709\u4e09\u4e2a\u7279\u70b9\uff1a<\/strong><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><span style=\"color: rgb(68, 135, 180);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u7b2c\u4e00\uff0c<\/strong><\/span>\u5b83\u662f\u4e00\u4e2a\u5355\u4e00\u7684\u6742\u5408\u5206\u5b50\uff0c\u5374\u80fd\u5e72\u4e24\u4ef6\u4e8b\uff0c\u582a\u79f0\u201c\u52b3\u6a21\u201d\u3002\u4e00\u4ef6\u662f\u963b\u65adTGF-\u03b2\u901a\u8def\uff0c\u4e00\u4ef6\u662f\u963b\u65adPD-1\/PD-L1\u901a\u8def\uff0c\u8b66\u544a\u5b83\u4fe9\u90fd\u8981\u89c4\u89c4\u77e9\u77e9\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><span style=\"color: rgb(68, 135, 180);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u7b2c\u4e8c\uff0c<\/strong><\/span>\u5b83\u7684\u4e00\u7aef\u662f\u80fd\u8bc6\u522b\u7ed3\u5408PD-L1\u7684\u6297\u4f53\uff0c\u53e6\u4e00\u7aef\u5219\u662f\u80fd\u8bc6\u522b\u7ed3\u5408TGF-\u03b2\u7684\u53d7\u4f53\uff08\u56fe2\uff09\uff0c\u201c\u4e24\u624b\u6293\uff0c\u4e24\u624b\u90fd\u8981\u786c\u201d\uff0c\u5b9e\u73b0\u540c\u65f6\u963b\u65ad\u4e24\u4e2a\u901a\u8def\u7684\u76ee\u7684\uff0c\u8ba9\u80bf\u7624\u7ec6\u80de\u65e0\u8ba1\u53ef\u65bd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img    style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"  src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress2-1533788491.jpeg\" alt=\"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01\" title=\"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: center;font-size: 12px;box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\">\u56fe2&nbsp; M7824\u7ed3\u6784\u793a\u610f\u56fe<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><span style=\"color: rgb(68, 135, 180);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u7b2c\u4e09\uff0c<\/strong><\/span>\u9274\u4e8eM7824\u7684\u4f5c\u7528\u673a\u5236\u548c\u5e94\u7528\u8303\u56f4\uff0c\u5b83\u662f\u4e00\u79cd\u53cc\u529f\u80fd\u6027\u514d\u75ab\u7597\u6cd5\uff0c\u53ef\u4ee5\u79f0\u4e3a\u7b2c\u4e8c\u4ee3PD-1\u836f\u7269\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u7b80\u5355\u7684\u7406\u89e3\uff0c<strong style=\"box-sizing: border-box;\">M7824\u5c31\u662fPD-1\u7684\u589e\u5f3a\u7248\uff0c<\/strong>\u80fd\u540c\u65f6\u9776\u5411TGF-\u03b2\u4e0ePD-L1\uff0c\u4f7f\u4e24\u4e2a\u7cfb\u7edf\u540c\u65f6\u8d77\u6548\u53c8\u5177\u6709\u534f\u540c\u4f5c\u7528\uff0c\u5927\u5e45\u63d0\u9ad8\u6cbb\u7597\u7684\u6709\u6548\u7387\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u6b64\u5916\uff0cM7824\u8fd8\u53ef\u80fd\u514b\u670d\u80bf\u7624\u7ec6\u80de\u5bf9PD-1\u6cbb\u7597\u7684\u8010\u836f\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u6309\u7167\u6297\u80bf\u7624\u836f\u7269\u7684\u7814\u53d1\u5957\u8def\uff0c<span style=\"color: rgb(68, 135, 180);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u836f\u7269\u8bbe\u8ba1\u51fa\u6765\u4e86\uff0c\u5c31\u8be5\u7528\u52a8\u7269\u8bd5\u9a8c\u6765\u9a8c\u8bc1\u662f\u5426\u6709\u6548\u4e86\u3002<\/strong><\/span><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u8bd5\u9a8c\u7ed3\u679c\u4ee4\u4eba\u5174\u594b\uff0c\u591a\u79cd\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u90fd\u8bc1\u5b9e\u4e86M7824\u5728\u4f53\u5185\u7684\u6709\u6548\u6027\u2014\u8ba9\u80bf\u7624\u4f53\u79ef\u5728\u5c0f\u9f20\u4f53\u5185\u5927\u5e45\u5ea6\u7f29\u5c0f\uff0c\u5176\u7597\u6548\u6bd4\u5355\u7528PD-L1\u6297\u4f53\u6216\u8005TGF-\u03b2\u6297\u4f53\u8981\u597d\u5f88\u591a\uff08\u56fe3\uff09\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img    style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"  src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533788491.jpeg\" alt=\"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01\" title=\"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: center;font-size: 12px;box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\">\u56fe3&nbsp; M7824\u52a8\u7269\u8bd5\u9a8c\u7ed3\u679c<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">2018\u5e741\u6708\uff0c\u7814\u7a76\u4eba\u5458\u62a5\u544a\u4e86M7824\u7684\u4e00\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u8be5\u8bd5\u9a8c\u5728\u65e2\u5f80\u63a5\u53d7\u6cbb\u7597\u768419\u540d\u665a\u671f\u764c\u75c7\u60a3\u8005\u4e2d\u8fdb\u884c\uff0c\u63a5\u53d7\u4e0d\u540c\u5242\u91cf\u7684M7824\u6cbb\u7597\u3002\u7ed3\u679c\u8868\u660e\uff0c1\u540d\u60a3\u8005\u5b8c\u5168\u7f13\u89e3\uff0c2\u4f8b\u60a3\u8005\u75c5\u7076\u6301\u7eed\u7f29\u5c0f\uff08\u56fe4\uff09\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u7814\u7a76\u4eba\u5458\u5df2\u5c06\u8bd5\u9a8c\u8303\u56f4\u6269\u5927\uff0c\u7eb3\u5165\u66f4\u591a\u60a3\u8005\u3002\u7814\u7a76\u4eba\u5458\u8fd8\u51c6\u5907\u5728\u80f0\u817a\u764c\u548c\u4eba\u7c7b\u4e73\u5934\u72b6\u7624\u75c5\u6bd2\u76f8\u5173\u764c\u75c7\u7684\u60a3\u8005\u4e2d\u8fdb\u884cM7824\u7684\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-sizing: border-box;\"><img    style=\"vertical-align: middle;max-width: 100%;box-sizing: border-box;\"  src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress8-1533788491.jpeg\" alt=\"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01\" title=\"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: center;box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><span style=\"font-size: 12px;box-sizing: border-box;\">\u56fe4&nbsp; \u60a3\u8005\u6cbb\u7597\u540e\u80bf\u7624\u75c5\u7076\u7684\u53d8\u5316\u60c5\u51b5\uff08\u4e0e\u57fa\u7ebf\u76f8\u6bd4\uff09<\/span><\/p>\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin: 10px 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;padding: 0px 10px;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: left;font-size: 18px;color: rgb(68, 135, 180);box-sizing: border-box;\">\n<p style=\"text-align: center;margin: 0px;padding: 0px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">03<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;box-shadow: rgb(0, 0, 0) 0px 0px 0px;border-top: 1px solid rgb(62, 62, 62);border-top-left-radius: 0px;padding: 0px 10px;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin: 10px 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"margin-bottom: -6px;line-height: 1em;padding: 0px 5px;font-size: 17px;letter-spacing: 1px;box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\">M7824\u95ea\u8000\u533b\u5b66\u5927\u4f1a<\/p>\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<section style=\"width: 100%;height: 10px;background-color: rgba(68, 135, 180, 0.15);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\">\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u57282018\u5e74ASCO\u5e74\u4f1a\u4e0a\uff0cM7824\u60ca\u8273\u4e16\u4eba\uff01<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u9996\u5148\u770b\u5176\u6cbb\u7597<span style=\"color: rgb(68, 135, 180);box-sizing: border-box;\">&nbsp;<strong style=\"box-sizing: border-box;\">\u975e\u5c0f\u7ec6\u80de\u80ba\u764c&nbsp;<\/strong><\/span>\u7684\u6570\u636e\uff0c40\u540dNSCLC\u60a3\u8005\u5728\u9ad8\u5242\u91cf\u7ec4\u4e2d\uff0cPD-L1\u8868\u8fbe\u4e0d\u5c0f\u4e8e1%\u7684\u9633\u6027\u60a3\u8005\uff0c\u8be5\u836f\u7684\u603b\u4f53\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe\u5230\u4e8640.7%\uff1b<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">PD-L1\u8868\u8fbe\u4e0d\u5c0f\u4e8e80%\u7684\u9ad8\u8868\u8fbe\u4eba\u7fa4\uff0cORR\u66f4\u662f\u9ad8\u8fbe71.4%\uff01<\/strong><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u5176\u6b21\uff0c\u6cbb\u7597<span style=\"color: rgb(68, 135, 180);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"> HPV\u611f\u67d3 <\/strong><\/span>\u7684\u764c\u75c7\uff0c\u5305\u62ec\u5bab\u9888\u764c\uff0c\u809b\u95e8\u764c\u6216\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u517116\u4f8b\u60a3\u8005\uff0c ORR\u8fbe\u523037.5\uff05\uff0c<strong style=\"box-sizing: border-box;\">\u5176\u4e2dHPV \u9633\u6027\u764c\u75c7\u60a3\u8005\u7684ORR\u9ad8\u8fbe45.5\uff05\u3002<\/strong><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">M7824\u4f5c\u4e3aTGF-\u03b2\u4e0ePD-L1\u7684\u878d\u5408\u6297\u4f53\u5728\u6cbb\u7597<span style=\"color: rgb(68, 135, 180);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"> \u5b9e\u4f53\u7624 <\/strong><\/span>\u65b9\u9762\u5c55\u793a\u51fa\u4e0d\u9519\u7684\u6548\u679c\uff0c\u5b89\u5168\u6027\u548c\u7597\u6548\u826f\u597d\uff0c\u4e0d\u6127\u4e3a\u7b2c\u4e8c\u4ee3PD-1\u6291\u5236\u5242\uff0c\u671f\u5f85\u8fd9\u6b3e\u836f\u7269\u66f4\u591a\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u7684\u516c\u5e03\u3002<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\">\u5c0f\u7f16\u76f8\u4fe1\uff0c\u4f34\u968f\u7740\u514d\u75ab\u6cbb\u7597\u7684\u4e0d\u65ad\u6539\u8fdb\u548c\u5b8c\u5584\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u65b0\u836f\u5c06\u4f1a\u51fa\u73b0\uff0c\u75c5\u53cb\u4eec\u80fd\u591f\u6d3b\u5f97\u8d8a\u6765\u8d8a\u4e45\uff0c\u8d8a\u6765\u8d8a\u597d\uff01<\/p>\n<p style=\"white-space: normal;margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;height: 200px;overflow-x: hidden;overflow-y: auto;box-sizing: border-box;-webkit-overflow-scrolling: touch;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin: 20px 0% 0px;box-sizing: border-box;\">\n<section style=\"display: inline-block;border-width: 2px;border-style: solid;border-color: transparent;padding: 0.1em 0.3em;color: rgb(142, 142, 154);font-size: 12px;text-align: left;box-sizing: border-box;\">\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\">1. Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-\u03b2. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29343622.<\/p>\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\">2.http:\/\/abstracts.asco.org\/214\/AbstView_214_217737.html.<\/p>\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\">3. Julius Strauss\uff0cet al\uff0c Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFb, in Advanced Solid Tumors\uff0cJanuary 3, 2018\uff0cClinical Cancer Research.<\/p>\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\">4. https:\/\/immuno-oncologynews.com\/2018\/03\/27\/new-y-trap-technology-shows-promise<\/p>\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\">-cancer-immunotherapy\/.<\/p>\n<p style=\"margin: 0px;padding: 0px;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin: 20px 0% 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;width: 60%;box-sizing: border-box;\"><img    style=\"vertical-align: middle;max-width: 100%;width: 100%;box-sizing: border-box;\" width=\"100%\"  src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533788491.png\" alt=\"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01\" title=\"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01\"  \/><\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin: 0px 0% 10px;box-sizing: border-box;\">\n<section style=\"font-size: 14px;letter-spacing: 5px;color: rgb(70, 87, 114);box-sizing: border-box;\">\n<p style=\"text-align: center;margin: 0px;padding: 0px;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u764c\u5ea6\u670d\u52a1\u9879\u76ee<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" ><a title=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247491418&amp;idx=2&amp;sn=4040ba15fcaa58666fc32660d89e0ecf&amp;scene=21#wechat_redirect\" formlinkparm=\"&quot;https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247491418&amp;idx=2&amp;sn=4040ba15fcaa58666fc32660d89e0ecf&amp;scene=21#wechat_redirect&quot;\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247491418&amp;idx=2&amp;sn=4040ba15fcaa58666fc32660d89e0ecf&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener noreferrer\" style=\"box-sizing: border-box;\"><\/p>\n<section style=\"text-align: center;margin: 10px 0% 20px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;border-width: 2px;border-radius: 5px;border-style: groove;border-color: rgb(250, 250, 250);box-shadow: rgb(250, 250, 250) 0px 0px 0px;width: 90%;overflow: hidden;box-sizing: border-box;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;margin: 0px;right: auto;bottom: auto;\"><img    style=\"vertical-align: middle;max-width: 100%;width: 100%;box-sizing: border-box;margin: 0px;\" width=\"100%\"  src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress7-1533788491.jpeg\" alt=\"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01\" title=\"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01\"  \/><\/span><\/section>\n<\/section>\n<p><\/a><\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" ><a title=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247491621&amp;idx=2&amp;sn=f81112744650511081c757f7845c5802&amp;scene=21#wechat_redirect\" formlinkparm=\"&quot;https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247491621&amp;idx=2&amp;sn=f81112744650511081c757f7845c5802&amp;scene=21#wechat_redirect&quot;\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247491621&amp;idx=2&amp;sn=f81112744650511081c757f7845c5802&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener noreferrer\" style=\"box-sizing: border-box;\"><\/p>\n<section style=\"text-align: center;margin: 10px 0% 20px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;border-width: 2px;border-radius: 5px;border-style: groove;border-color: rgb(250, 250, 250);box-shadow: rgb(0, 0, 0) 0px 0px 0px;width: 90%;overflow: hidden;box-sizing: border-box;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;margin: 0px;right: auto;bottom: auto;\"><\/span><\/section>\n<\/section>\n<p><\/a><\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" ><a title=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247491621&amp;idx=3&amp;sn=585b4d9ba8c293fd7a9f67bb3cba1b04&amp;scene=21#wechat_redirect\" formlinkparm=\"&quot;https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247491621&amp;idx=3&amp;sn=585b4d9ba8c293fd7a9f67bb3cba1b04&amp;scene=21#wechat_redirect&quot;\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI4MzIxOTU2Mw==&amp;mid=2247491621&amp;idx=3&amp;sn=585b4d9ba8c293fd7a9f67bb3cba1b04&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener noreferrer\" style=\"box-sizing: border-box;\"><\/p>\n<section style=\"text-align: center;margin: 10px 0% 20px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;border-width: 2px;border-radius: 5px;border-style: groove;border-color: rgb(250, 250, 250);box-shadow: rgb(0, 0, 0) 0px 0px 0px;width: 90%;overflow: hidden;box-sizing: border-box;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;margin: 0px;right: auto;bottom: auto;\"><img    style=\"vertical-align: middle;max-width: 100%;width: 100%;box-sizing: border-box;margin: 0px;\" width=\"100%\"  src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/08\/beepress9-1533788491-1.jpeg\" alt=\"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01\" title=\"\u7b2c\u4e8c\u4ee3PD-1\u6297\u4f53\u6a2a\u7a7a\u51fa\u4e16\uff0c\u98ce\u534e\u521d\u73b0\uff01\"  \/><\/span><\/section>\n<\/section>\n<p><\/a><\/section>\n<\/section>\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u764c\u5ea6                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6587\u4e28\u98de\u5b87 \u5982\u4eca\uff0c\u4ee5 PD-1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242 \u4e3a\u4ee3\u8868\u7684\u514d\u75ab\u80bf\u7624\u6cbb\u7597\u65b9\u6848\uff0c\u6b63\u6380\u8d77\u80bf\u7624\u6cbb\u7597\u7684\u9769\u547d\uff0c\u5f15\u9886\u764c\u75c7\u6cbb\u7597\u7684\u53d8 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":32215,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/32214"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=32214"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/32214\/revisions"}],"predecessor-version":[{"id":32229,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/32214\/revisions\/32229"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/32215"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=32214"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=32214"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=32214"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}